LOCUS       NZ_BMTZ01000010        21257 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces variabilis strain JCM 4422 sequence10, whole genome
            shotgun sequence.
ACCESSION   NZ_BMTZ01000010
VERSION     NZ_BMTZ01000010.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces variabilis
  ORGANISM  Streptomyces variabilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces griseoincarnatus
            group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 210101)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 156X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649935.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:37:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,743
            CDSs (total)                      :: 6,668
            Genes (coding)                    :: 6,496
            CDSs (with protein)               :: 6,496
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 172
            CDSs (without protein)            :: 172
            Pseudo Genes (ambiguous residues) :: 0 of 172
            Pseudo Genes (frameshifted)       :: 61 of 172
            Pseudo Genes (incomplete)         :: 147 of 172
            Pseudo Genes (internal stop)      :: 11 of 172
            Pseudo Genes (multiple problems)  :: 42 of 172
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:23:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 147515
            Orig. end                         :: 168772
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMTZ01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21257
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="1"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21257
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21257
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11257](-)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11257)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     gene            complement(137..2356)
                     /locus_tag="IE148_RS18290"
                     /old_locus_tag="GCM10010287_36980"
     CDS             complement(137..2356)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004994192.1"
                     /locus_tag="IE148_RS18290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_36980"
                     /product="DNA-binding transcriptional regulator"
                     /protein_id="WP_189365352.1"
                     /transl_table=11
                     /translation="MSELFDAVDALIASRSPLPPPAERKRLRQAHGLTLDEVAAALQVR
                     RATVSGWEAGKTEPRPPERDAYARMLKQLAQLYPAVAPVPPEDTAIPETPAVPAAPAPS
                     AAEPAQARTAPTGPAAKPANTALRPVAPAPVPRPAVSTRPTSRRPAAKRAAPASAPAGG
                     ADPRFENGPLAVVDVADGQVLAYCVGGLVLDVAAKSLPALVEWTLREGRFGQPKLSGPG
                     KDADPLIVLTGAACEHYGLPVTLTQQERLAGRLPEGHKVIKQLTRANWQLTKRGFGPWA
                     RIYRPAQGSERACVQLCIPSWDALDTRHWADAGQLPPADLARLLGTYATRVMTPRGSTA
                     VTGLELMTALHPPTRASEPDATGKRHSEHNPGSLGKDPVDCAPCEAPDGHPLLADLPRF
                     HQRTPAEVLVEEAYDWARPLTDAECLRPHLVGIDVNMAFAAGANGLNVGLGAPTHVKSP
                     VFDPKLPGSWLVDLSHVDLSRVKLANQWTDLDGELLPSPFTPKGERPQGPAWYATPTVA
                     YAVELGYDVRPVEAYVRHDNGRYLDAWYNRLRDAYLATMADLGVYADMPPAEFLAAMDG
                     YRQRDPQLAIVVSAIKATVKGGIGKLRERPRGEGWKPGQPWRALARPTWRPDIRAAVIS
                     RTRINMHRKIVKHAAFTGQYPVAVLSDCAVYASDGPTPLDFLPYRDGKPLPGGFKLGLN
                     PGLVKHEGTQSVLWGEGVREQFNAPELNLARYIKDGTVTDQDTGE"
     misc_feature    3070..3084
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.54"
                     /tool="antismash"
     misc_feature    complement(3071..3086)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.68"
                     /tool="antismash"
     gene            3338..3940
                     /locus_tag="IE148_RS18300"
                     /old_locus_tag="GCM10010287_37000"
     CDS             3338..3940
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE148_RS18300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010287_37000"
                     /product="hypothetical protein"
                     /protein_id="WP_189365353.1"
                     /transl_table=11
                     /translation="MHVFRPAGRHRAQGRRSQVLLTGALTIGTAGAALGMGAPAHASPA
                     DIGSDGAAMQQSTDDTPSLGALLPTHSGVDAQSQRLLASLEQLTDEDTAQTLRKFIVEG
                     QKIHGVKDLASSPSYLRDVLVDGFLSYYDKAFGADMLLYGRTEERRREIMTNMGVPPAL
                     QPVMNYVLSRTPELRQQLMSRNSELLNSELPNVEDQP"
     gene            complement(4618..4908)
                     /locus_tag="IE148_RS33390"
                     /old_locus_tag="GCM10010287_37010"
     CDS             complement(4618..4908)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE148_RS33390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010287_37010"
                     /product="hypothetical protein"
                     /protein_id="WP_189463192.1"
                     /transl_table=11
                     /translation="MSEPYSVGWAMASSLPTARTTRAARTRQALLTPWRTERTGRAVGD
                     GAGDDVLAAAGAGRPQAQSVDALAVEIIEDPAKREGADLGLDKPGTDGDRP"
     misc_feature    complement(4956..4972)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.18"
                     /tool="antismash"
     gene            complement(5117..5476)
                     /locus_tag="IE148_RS18310"
                     /old_locus_tag="GCM10010287_37020"
     CDS             complement(5117..5476)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE148_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010287_37020"
                     /product="hypothetical protein"
                     /protein_id="WP_086700177.1"
                     /transl_table=11
                     /translation="MHVVIAWWEQHRNGTQSHTGTTRQVMPSTSFAPRQGATALTADIP
                     GLRSGRWITDPAANLQGLALIWDSAASADLNLPNVCDRTFGCAPSHRWTFELPGTPPQD
                     NLQSLPDELNVLLHA"
     gene            complement(5569..6336)
                     /locus_tag="IE148_RS18315"
                     /old_locus_tag="GCM10010287_37030"
     CDS             complement(5569..6336)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-184). E-value: 2.3e-12. Score:
                     39.1. Matches aSDomain:
                     nrpspksdomains_IE148_RS18315_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953115.1"
                     /locus_tag="IE148_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37030"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_189365355.1"
                     /sec_met_domain="adh_short (E-value: 6e-33, bitscore:
                     107.8, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGALTGRTALVTGGSRGIGRAIAERLAADGATVAVHYGRSAAAAD
                     EVVEGIRAKGGTAFTVHAELGAEGDVATLWESFDRQVLEHATSTGLDILVNNAGVTPRG
                     EIDETTAEAFEEAVAVNMRAPFFLTQQALKRLRDGGRIVNVSSGATRIALTDIIAYAMT
                     KGAIDAFSLTLAKALGPRGITVNSVAPGIIDTDINASWLRGNEAAERSAAELSALGRVG
                     RPEDVADVVAFLASDDARWVTGQVLDATGGSQL"
     aSDomain        complement(5785..6315)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE148_RS18315_PKS_KR.1"
                     /evalue="2.30E-12"
                     /label="IE148_RS18315_PKS_KR.1"
                     /locus_tag="IE148_RS18315"
                     /protein_end="184"
                     /protein_start="7"
                     /score="39.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TALVTGGSRGIGRAIAERLAADGATVAVHYGRSAAAADEVVEGIR
                     AKGGTAFTVHAELGAEGDVATLWESFDRQVLEHATSTGLDILVNNAGVTPRGEIDETTA
                     EAFEEAVAVNMRAPFFLTQQALKRLRDGGRIVNVSSGATRIALTDIIAYAMTKGAIDAF
                     SLTLAKALGPRGIT"
     CDS_motif       complement(6244..6309)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE148_RS18315_0001"
                     /evalue="7.50E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE148_RS18315"
                     /protein_end="31"
                     /protein_start="9"
                     /score="21.8"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAIAERLAADGA"
     misc_feature    complement(6395..6413)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.42"
                     /tool="antismash"
     misc_feature    6402..6416
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.26"
                     /tool="antismash"
     misc_feature    6426..6442
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.78"
                     /tool="antismash"
     gene            6441..7055
                     /locus_tag="IE148_RS18320"
                     /old_locus_tag="GCM10010287_37040"
     CDS             6441..7055
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020140681.1"
                     /locus_tag="IE148_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37040"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_189365356.1"
                     /transl_table=11
                     /translation="MTTTKRGRPRGFDRDTALAQATSLFWQHGFEGTSIADLTSAMGIS
                     PPSLYAAFGDKRTLFHEVVERYGGTFGAFMDKALTEESDPRRGFARMLDEAALAYTDPS
                     HPAGCLVITAATNYSKQTADIERDLRERRRANVRSFETRLEDARSRGSLGQDTDTRALA
                     VYFAAVVQGMSQQARDGATAQELRRVAELAMTVWPPSGASS"
     misc_feature    complement(6481..6491)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(7124..7600)
                     /locus_tag="IE148_RS18325"
                     /old_locus_tag="GCM10010287_37050"
     CDS             complement(7124..7600)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024854.5"
                     /locus_tag="IE148_RS18325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37050"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_189365357.1"
                     /transl_table=11
                     /translation="MAEPYTNENHDAETENVSRLWERVVPMFSLLEGRLDRVLTLRHNV
                     GLGQLMALGVLAGEQSTPATVSDVARRLGLSVSAASRMLAHLERSGWTDKVAWPCDRRT
                     SRVAITEAGLAVWRRARETLERELDHAFTTLKFDERYAHVASRLCRVDGGPPAL"
     gene            complement(7758..8666)
                     /locus_tag="IE148_RS18330"
                     /old_locus_tag="GCM10010287_37060"
     CDS             complement(7758..8666)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (20-194). E-value: 6.5e-28.
                     Score: 89.7. Matches aSDomain:
                     nrpspksdomains_IE148_RS18330_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136124.1"
                     /locus_tag="IE148_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37060"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_189365358.1"
                     /sec_met_domain="ADH_N (E-value: 1.1e-11, bitscore: 38.2,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 6e-10, bitscore:
                     32.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVVLTSFGGPEGLSVSEIAEPAGPDPDGVLIRTAAAAVNPVDL
                     QTRGGLHTGHSAFRPPMVLGWDVAGTVTAVGEQVTRFRPGDRVVAMSAQMATGRGTYAE
                     TVALPADIVAPAPRTVELTTAAGLPLASLAGAQALDAFDLPAGATLLVTGAVGAVGGMA
                     VQLAKLRGWRVVAQVRSARDEDTARALGADRVVDEAGLSPRTVDGLLETAGLPGAISAV
                     RDGGRVVSIVPTRVPAAERGIRVTVSHVEQDGPRLAEMAALVDASKLRLRTSKQLGFED
                     AAEAHRLLEAGGVRGKLLLLP"
     aSDomain        complement(8085..8606)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE148_RS18330_PKS_ER.1"
                     /evalue="6.50E-28"
                     /label="IE148_RS18330_PKS_ER.1"
                     /locus_tag="IE148_RS18330"
                     /protein_end="194"
                     /protein_start="20"
                     /score="89.7"
                     /tool="antismash"
                     /translation="AEPAGPDPDGVLIRTAAAAVNPVDLQTRGGLHTGHSAFRPPMVLG
                     WDVAGTVTAVGEQVTRFRPGDRVVAMSAQMATGRGTYAETVALPADIVAPAPRTVELTT
                     AAGLPLASLAGAQALDAFDLPAGATLLVTGAVGAVGGMAVQLAKLRGWRVVAQVRSARD
                     EDTARALGADR"
     CDS_motif       complement(8187..8207)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE148_RS18330_0002"
                     /evalue="9.90E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="IE148_RS18330"
                     /protein_end="160"
                     /protein_start="153"
                     /score="-3.7"
                     /tool="antismash"
                     /translation="GAVGAVG"
     CDS_motif       complement(8439..8477)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE148_RS18330_0001"
                     /evalue="3.90E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="IE148_RS18330"
                     /protein_end="76"
                     /protein_start="63"
                     /score="10.3"
                     /tool="antismash"
                     /translation="LGWDVAGTVTAVG"
     gene            complement(8734..9183)
                     /locus_tag="IE148_RS18335"
                     /old_locus_tag="GCM10010287_37070"
     CDS             complement(8734..9183)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019498.5"
                     /locus_tag="IE148_RS18335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37070"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_189365359.1"
                     /transl_table=11
                     /translation="MIISTTDDAVRVAVPSDTGQGAEREAGTSTGTGPRTGGGDAAAMW
                     TCLVRRGMLHSECEAVEHWRLPPGGVLASTPQHGVEEAVLVLNGELRLTTESAERVLRA
                     GQLALLPHGAQARLTAEGAQTRLLVLRTLTASVTGRLPSRIPELV"
     gene            complement(9180..10004)
                     /locus_tag="IE148_RS18340"
                     /old_locus_tag="GCM10010287_37080"
     CDS             complement(9180..10004)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019498.5"
                     /locus_tag="IE148_RS18340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37080"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_189365360.1"
                     /transl_table=11
                     /translation="MTTEAAVRPGPVPSADPASGRTACHEPRTSPAPWRSLGTVAGAAT
                     VYGVHGAAGRTRWKCFAGRRQLHSPTEAVEWASVPPGGLSGEHRHTRTEEIYLVLRGRG
                     EFLFNGRPHPAGPGTLALTAPGNVHGLRNTGKDDLDWWVIETLAPGTDAVLSGAAHHHP
                     GVPPMGEAVIHDLFKERTVSTSGVFTGPLRQVEVVELDAGERTRLGAPDAELAVFVHEG
                     TGRATADGHTAVLASDTCLTLGASTVTGVEAVTPLRLLVVTLSVPRSAPEAS"
     gene            complement(10001..11257)
                     /locus_tag="IE148_RS18345"
                     /old_locus_tag="GCM10010287_37090"
     CDS             complement(10001..11257)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894817.1"
                     /locus_tag="IE148_RS18345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37090"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_246539083.1"
                     /sec_met_domain="salQ (E-value: 4.6e-182, bitscore: 598.4,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Fe-ADH (E-value: 6.5e-10, bitscore: 31.8,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 2.7e-69, bitscore:
                     226.7, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQQDTQTMRNNDGLFAVGSPVTHWSVQTSNPVQYEIRACENLLDP
                     GNSTILEDASGSSGQRRLIVTDGVVDSLYGDRVRAYFDHHGVEHRVLVLNDGETHKSMD
                     AVLQVTEALDAFGIDRRREPVIAIGGGVLMDIVGFAASLYRRSTPFIRIPTTLIGLVDA
                     GVGAKTGVNHNGHKNRLGTYFPADRTLLDRSFLATLDARHISNGLAEILKIALIKDARL
                     FDLLEQHGADLLRNKLQSPAAVGPTPADAPVDQRLAARGLHLDPATEVVERAIQGMLEE
                     LQPNLWEKVLERVVDYGHTFSPTIEMHALPALLHGEAVAVDMALTTVLAERRGLVSSYQ
                     RDRVLDVMARLGLPVWHPLCTPEVLGDALRDTVRHRDGKQRLPLPVGIGSALFVNDVTE
                     GELAAAAESLAALGSGVSR"
     gene            complement(11744..12187)
                     /locus_tag="IE148_RS18350"
                     /old_locus_tag="GCM10010287_37100"
     CDS             complement(11744..12187)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF047172.1"
                     /locus_tag="IE148_RS18350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37100"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_189365361.1"
                     /transl_table=11
                     /translation="MRARKEDSIELWSQLSVLVAEVGTALDRRLSEDYELGLTDFLALR
                     ALANGDPSGMRMNELAQLLGLNQSSATRVVQRLESRSLAEKGAHATDRRGVVVRVTDAG
                     RDLAAEIGGLFRREVGMAFEVASMDNRTSSVVARLRYAPRLDR"
     misc_feature    12337..12351
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.6"
                     /tool="antismash"
     gene            12611..13675
                     /locus_tag="IE148_RS33395"
                     /old_locus_tag="GCM10010287_37110"
     CDS             12611..13675
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034422.1"
                     /locus_tag="IE148_RS33395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37110"
                     /product="VOC family protein"
                     /protein_id="WP_220450285.1"
                     /transl_table=11
                     /translation="MLNAVPASPPVHTGLPTARAVDHYAFTVPRLDEAVAYAVDVLGGR
                     LCYREGPVEDPSGDWMTRKLGVHPRARAQVALVRLGPCTNLELFEYTAPDQLLAPPGPN
                     DVGGHHLALTVADPDAAEDHLRRAGTVRLGPAGPPGTAHRWFLTPWGMLLSVRGPLRPD
                     GRRFVPAPDPHPTAVQSALGLLGVEHVGYTVADLDAGVAFFTDVLGAEVVESGAAPDTG
                     PDGHRPPGAEQSRRVLLRTGPTANCELVQSGTGALRSRPPRNSDIGGHHLAFYVDDVDA
                     AAAYLREQRGVVLMGEPETITQGPIAGDRWLYFSTPIGIQMEILSMPDGSLPYERQTTA
                     RRATPGSLRWHDRP"
     gene            13858..14607
                     /locus_tag="IE148_RS18365"
                     /old_locus_tag="GCM10010287_37120"
     CDS             13858..14607
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE148_RS18365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010287_37120"
                     /product="hypothetical protein"
                     /protein_id="WP_189365362.1"
                     /transl_table=11
                     /translation="MDTLTPLPVRPAGPLRRAAAARVALWLDRRRAPEPDGPTAGPVLD
                     LAGAADAVQDLLPPASENRSSGQLTAHGIRVVGPVHGGAGHRRLMRRLLSEVSSASPAA
                     RPTAIEYCVPAVDALVDARLDQVGGWEAKAMRSRAGIAGAHLLYDMHRRELASPQWTEA
                     VARGAAAPRLLWSTRPGAGPDRGADLARRLLLPGTAVALSPRSLESFARHGVVTGPTVP
                     DLAEAHRVVGVLDWFGIRLDDLDSPAG"
     misc_feature    13876..13878
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14732..16465
                     /locus_tag="IE148_RS18370"
                     /old_locus_tag="GCM10010287_37130"
     CDS             14732..16465
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449454.1"
                     /locus_tag="IE148_RS18370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37130"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_189365363.1"
                     /transl_table=11
                     /translation="MLSPASLPSDADTSAGPATADAAGRPAAQTAVRPRVHRRRFLSGT
                     AAAGGALAVTAAGLGSAAAAETGRGGPLAGSPAGAAAAPVTVRPADRRYADLRRGTNQR
                     WVGSPEHIVLATSTADVVRAVQQAVDSGRRLAVRSGGHCYENFTTSDDIAILLDLSRMD
                     DIAYDERRRAFSVQPGAALGRVYDRLYKGWGVYLPAGNCPTVAAGGHIPGGGYGSMSRR
                     DGLAVDHLYGVEIVVVGADGRARAVTATREPGDPNRELWWAHTGGGGGNFGVVTRYWLR
                     SPDARGDDPAAQLPAPPREVWLSEVAWPWEELTESRFTRLMWNHGDWHTRNSAPDSPYT
                     ALFSQLKPFHKSGGAVVLDSLVDADAPGAERLLRTYIAEVGAGIGIQPQVRQYRRMPWL
                     HATQWPGFTGPDPTVRFKGKSVYARRTYTDAQISAAYRHLTRDDFHNPGALLMIASYGG
                     AVNRVAPDATAVPQRDSVLKYQVVSLWQDAADDAANIAWVRECYRDMFAATGGVPVPND
                     TTDGCFVNYADVDLGDPRWNSSGVPWHELYYKGGYRRLQKVKAAWDPTGFFRHAQSVRP
                     A"
     gene            16624..17787
                     /locus_tag="IE148_RS18375"
                     /old_locus_tag="GCM10010287_37140"
     CDS             16624..17787
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010644125.1"
                     /locus_tag="IE148_RS18375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37140"
                     /product="acyltransferase"
                     /protein_id="WP_189365364.1"
                     /transl_table=11
                     /translation="MRFFAAFLVFLFHLSLLDAYSTPGEQHGPFASAVKNGGWAGVTFF
                     FILSGFVLAWSARDGDTTTSFWGRRIVKIAPNHVVTFFVALACYAYASATWGAGIPNFL
                     LLQAWVPRDDVFFSINNPSWSLSCELVFYLLFPALYRRVRRIRAERLWWWAGGTAMVII
                     SLPLLVQLLPAGESFGPNHANSPLYGHSITQMWLVYIFPPARVLDFLLGILMARIVLTG
                     RWVGLGVLPALAVTLTAYVLSLQAPFLFSLNAVVVVPFALLISAAAARDAQGRGTAVGG
                     RVWVWLGEVSFAFYLVHQILLSVLQERFGYRETGSLAEAAGVAVLIAAVSLLLAWLLYA
                     GVERPAVRAWARRGRARTLRVARDQPSADGPGPGSEESDRPVTVGTP"
     gene            17872..19143
                     /locus_tag="IE148_RS18380"
                     /old_locus_tag="GCM10010287_37150"
     CDS             17872..19143
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="IE148_RS18380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37150"
                     /product="MFS transporter"
                     /protein_id="WP_189365365.1"
                     /transl_table=11
                     /translation="MPLPVLAMMLCTFCIGTAESVIAGILPGIAQDVGVSLTAVGLLIT
                     VYAAAVVLVGPLVTAATATLRRATLLPAMMGVFVMGNTLGASAPGFGWLLVGRVVSAVV
                     HSTLIAAFVAAARDTAPPDRRAAYGAKVTLGIGLSSVAGVPAGTLIGNAFGWRATFWAL
                     AAVSLAATALLTRFPAPESPRGTAKPAGLRRTAAPDTGPGRRRFVLPGPMLLVAAVITL
                     GTAGVFALYTYASPYLTQSAGFGSGSVTVLLLLYGLGGIVGNTAGGRAADRFPSAAVPA
                     TLGAAAAGLLLLALPPGNRWAVAGVFCLLGTAYFATIPALNNAIVSAAGPSSSTMALTV
                     NNSAFCVGIALGSWLGGLLLARGNTLPTVAAAGAASTAAALLLALLHTRLRKAPPGPAL
                     PATGASHDTGTGTGTTVAGSGVPR"
     gene            19756..20757
                     /locus_tag="IE148_RS18385"
                     /old_locus_tag="GCM10010287_37160"
     CDS             19756..20757
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123145.1"
                     /locus_tag="IE148_RS18385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_37160"
                     /product="TIGR00341 family protein"
                     /protein_id="WP_189365366.1"
                     /transl_table=11
                     /translation="MIGKVRTRVLPASQRRSLDELTEDLDLSSGDTTSRRSAFWTMLTL
                     SSVIASGGVLTDSTATVIGAMIIAPLSTPIMGIALGSVKRRRTGSARVVLLACLLVTAV
                     GMAVSVALPGDYDLLSNSQISSRTSSGLMDLIAALATGFAGAVALARRDVAAVLPGVAI
                     AISLVPPLVVAGVCLGQLSGWLALGALVLFVSNLFALVFGGMVVFASLGYGTEADKAAG
                     RPARRTYAAMILLFTAVFVPLTANTVITLLLDTWTGRTKDAAQQWLADVPDASVTSVDA
                     TSRTMYVHVRSPGDLPPVESLLDRLEGRIPDGIPVAVDTSRGRRIDAGVVGG"
     gene            complement(20868..21137)
                     /locus_tag="IE148_RS18390"
                     /old_locus_tag="GCM10010287_37170"
     CDS             complement(20868..21137)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE148_RS18390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010287_37170"
                     /product="hypothetical protein"
                     /protein_id="WP_086700172.1"
                     /transl_table=11
                     /translation="MPIARPPRLAGSDHAYQHLPFGTFPDDAVALGREKPELRGIAPHL
                     HIPQVGDAEARDLRRRNVIGRMRATELSVSSVCGLLPASPSRAA"
     misc_feature    complement(21160..21171)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    21172..21186
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 tctgggcgac cgccttggtg cccttgagct gtttgaccag gtagcgcatc tgcgcgggcg
       61 cgctcttggg cgccgggcgg gtgaacgcct tctgcaccgc ggcgtccagg ccgtccccga
      121 acatgctcat cgcggtctac tccccggtgt cctggtcggt gacggtgccg tccttgatgt
      181 accgggcgag gttgagttcc ggggcgttga actgctcgcg gacgccctcg ccccacagca
      241 cgctctgggt gccctcgtgc ttcaccaggc ccgggttcag tccgagtttg aagccgccgg
      301 gcagcggctt gccgtcccgg tagggcagga agtccagcgg ggtgggtccg tcggaggcgt
      361 agacggcgca gtccgagagg accgccaccg ggtactggcc ggtgaaggcg gcgtgcttga
      421 cgatcttgcg gtgcatgttg atgcgggtgc gggagatgac ggcggcgcgg atgtccgggc
      481 gccaggtggg ccgggcaagg gcccgccagg gctgcccggg cttccagccc tccccgcgcg
      541 ggcgttcgcg cagcttgccg atgccgccct tcacggtcgc cttgatcgcg gacaccacga
      601 tcgccagctg agggtcacgc tgccggtaac cgtccatcgc cgcgaggaat tcggccggcg
      661 gcatgtcggc gtacacgccg aggtcggcca tcgtggcgag gtaggcgtcg cgcagccggt
      721 tgtaccaggc gtccaggtag cggccgttgt cgtggcggac gtatgcctcg accgggcgga
      781 cgtcgtagcc gagctccacc gcgtacgcca cggtcggcgt ggcgtaccag gccggaccct
      841 gcgggcgctc gcctttcggg gtgaacgggc tcggcagcag ctcgccgtcc agatccgtcc
      901 actgattggc gagcttcacg cgggacaggt cgacgtggct caggtcgacc agccaggagc
      961 cgggcagttt cggatcgaag acggggctct tgacgtgcgt cggcgcgccc aggccgacgt
     1021 taaggccgtt cgcgccggcg gcgaaggcca tgttcacgtc gatgcccacc aggtgggggc
     1081 gaaggcattc ggcgtcggtg agcgggcgcg cccagtcgta cgcctcctcc accaggacct
     1141 cggccggggt gcgctggtgg aaacgcggca gatcggcgag cagcgggtgc ccgtcgggtg
     1201 cctcgcacgg cgcgcagtcc accgggtcct tgcccaacga gccggggttg tgctcggagt
     1261 gccgcttgcc cgtcgcgtcc ggttcggagg cgcgggtcgg cgggtgcagg gcggtcatca
     1321 gctccagacc ggtcacggcg gtcgacccgc gcggggtcat cacgcgggtc gcatacgtgc
     1381 ccagcagccg ggccaggtcc gccggcggca gctgccccgc gtcggcccag tgtcgggtgt
     1441 cgagcgcgtc ccacgacggg atgcacaact gcacgcacgc ccgctccgag ccctgtgcgg
     1501 ggcggtagat ccgcgcccac ggcccgaagc cgcgcttggt cagctgccag ttggcacgcg
     1561 tcagctgctt gatgaccttg tggccttccg gcagccgccc ggccaggcgc tcctgttgtg
     1621 tgagcgtgac gggcaggccg tagtgctcgc acgcggcccc ggtcagcacg atcagcgggt
     1681 cggcgtcctt gcccggcccg gacaacttcg gctggccgaa ccgcccttcg cgcagcgtcc
     1741 actccaccag cgcgggaagc gacttggcag ccacgtccag gaccaggccg ccgacgcagt
     1801 acgccagcac ctggccgtcg gcaacgtcga cgaccgcaag cggaccgttc tcgaaccgcg
     1861 gatctgcgcc gcccgccggg gcgctggcgg gggcggccct cttcgcggcc gggcgccgcg
     1921 aggtcggcct ggtcgagaca gccgggcgcg gtacaggggc aggggcgacg gggcggagtg
     1981 cggtgttcgc gggcttggca gccgggcctg tgggtgcggt gcgggcttgg gccggttcag
     2041 ctgccgaggg cgcaggagcg gctggaacgg caggggtctc ggggatcgcc gtgtcctcgg
     2101 ggggcactgg agcgactgcg gggtagagct gggcgagttg cttgagcatg cgggcgtatg
     2161 cgtcgcgctc cggtggccgc ggttcggtct tgccggcctc ccagccgctg accgtcgcgc
     2221 gccgcacctg cagtgcggcg gccacctcgt ccagcgtcag gccgtgcgcc tggcgcagcc
     2281 gcttgcgttc cgccggtggc ggcaacgggg agcgggacgc gatgagcgcg tcgaccgcgt
     2341 cgaacagctc ggacatgcag cacctcctgt tcccgcaacc ctagcgtgaa gcgcactttt
     2401 cgcgtaccga acgcgtacgg atcccgtaag cggcggttgg cacggttgtt ccgggaaggg
     2461 gtgccctcgg acctcagctg cttcgtgctc cttggccgag ggtcgtggtc acgcgcacct
     2521 tggtcggagc gcaggatcag acgaaggccg tctctgcgtc cggcggattc ccatgccagg
     2581 gaatccgttc gagacgccat gcgagaccgt ggcaccatgt gccgcatgac gacgaaccga
     2641 aaggtccatg ccgcgtagac ggccagggca gatccgtgcc ggcgcccccg gcagccaccg
     2701 gacaacgggt gcaaggccgg tcatcgacgg cctgtcttcg cgtgcgctgt ccgagatcag
     2761 ccgcctcgag cacacccgca actatctgca gccaggcgat gtcagcacag ctgcaggcct
     2821 gtggaagaac tacgtccacc agcccgagcg ggatctgtgg cacgaccacg agtggggcaa
     2881 cgtgcactgg tactgctgcg gcaaccctct cgaatcccgg gccctcctcg acgccgtgat
     2941 gcaggccctg tcacgccgaa gtgcccgcga attccgcgag attgtcagcc ggtcagacgc
     3001 cgtctggaac cgcccgtccc cgccctatgg cgcggacggt agatagagaa caagctcaga
     3061 agctgtgcca gaacatcatt ctcgttacgc tcagtcacct gtgcctggtg gatgcgactc
     3121 cacccgctca ggcgcaccgc aggagcgtgg cctggcgcac tgggctactc cggttggcgc
     3181 cgcgccgagt ggtcgcctac agccagttcg ggcggtggcc cgcccggcag tcctggcctg
     3241 gccctccgtg agacacgctc gaccgccggc gggtcccagt gaccggccgt cgccccgagt
     3301 cgttcaccgg gtgaacacgc accacgaagg agatccgatg cacgtctttc gccccgcagg
     3361 ccggcaccgt gcccagggcc gccggagcca ggtcctgctc accggggccc tcacgatcgg
     3421 caccgccggc gctgctcttg ggatgggcgc tccagcccac gcctcgcccg cagacatcgg
     3481 atccgacggc gctgcgatgc agcagagcac cgacgacacc ccttcccttg gcgcgctcct
     3541 ccccactcac tcgggggtgg acgcgcagag ccaacgcctg ctcgcttctc tggagcagct
     3601 gacggacgaa gacaccgctc agacactgcg gaagttcatc gtcgaagggc agaagatcca
     3661 cggcgtcaag gacttggcca gcagcccctc gtacctccgc gacgttctcg tcgacgggtt
     3721 cctgtcctac tacgacaagg ccttcggggc cgacatgctc ttgtacggcc gcacggagga
     3781 gaggaggcgg gagattatga cgaacatggg agtcccgccg gcgctgcagc cggtgatgaa
     3841 ctatgtgctc agcaggacgc ctgagctgcg gcagcagctc atgagcagga actccgagct
     3901 cctgaactcc gagctcccga acgtcgagga ccagccctga cggtctgccc agcagggcct
     3961 cccgccccgt caccggccgg cttggcgcgg accgtccaca cgcccgctat gggagctacg
     4021 ccggtgggtg gtctccgggc gcccaccgaa atgtcgcggg cacctgacca cccaccacac
     4081 gctgcccgcc tccgatcgcc gtacgaacgc gccggcacac cacgacgatc cgctcacagc
     4141 gtcaccaatc gcgggttgtg gcacagctcc tgaggggcag gtgggcgctg atcagcagcg
     4201 gattccgctg aactggggcg tgtatgggaa cgtgtagtca tccccgaaga cccaacttcc
     4261 ctggtcgacc agcctcggct gcagaggcac gaatgcgctc acaccgttct tcgtgatacg
     4321 aacctggcct ccgaccgtat ggcattccac atcgtcgtca tcacgaaagg cggcgttccg
     4381 gccgcacttg aagttttcga cggaaacctt tgtctggttt cccccgggct cgacgcagat
     4441 acggaatgtg acgtcgtagt cggtctggta ccaggcacga tcagtaacaa ggcgctgttc
     4501 atcgcaccgc ttctcgacgg cggccgccgg agaggtgccg agaccggaac cagaaggccc
     4561 tcacctgttc acgcccccag cacgcgtgtc acccacgtgc cccagcccgg ccattggtca
     4621 ggggcggtcg ccgtctgtgc cgggcttgtc caatcccagg tccgcgccct cccgtttggc
     4681 ggggtcctcg atgatctcga cggcgagggc gtccacggac tgtgcctgtg ggcggcccgc
     4741 tccggcggcg gcgaggacat catcaccggc tccgtcaccc acagcccggc ccgtccgttc
     4801 ggtccgccat ggcgtcaaca gcgcctgcct ggttctggcc gccctggtcg tcctcgccgt
     4861 cggcagcgaa ctcgccatcg cccaccccac cgagtacggc tcgctcaccg tcgcactgct
     4921 cctcttcggc ggtcccgtgc tcacctcgcc accgccgcct ggttcttcgg caccaccacc
     4981 ggcggagcct ggaagggtgc ctctgccggc gtggcgacgg cacggtggtc ggcggtcgcg
     5041 cggggagggt gccgcagtgg gctgttccgg gccgggcggc tgttcggccg tccggcccgg
     5101 acgcgggtgc gccaggtcag gcgtgcagga ggacgttgag ctcgtcgggg aggctctgca
     5161 ggttgtcctg gggcggagtg ccggggagct cgaaggtcca gcggtgcgag ggcgcgcagc
     5221 cgaatgtgcg gtcgcacacg ttcggcaggt tgaggtcggc gctggccgcc gagtcccaga
     5281 tcagagccag gccctggagg ttcgctgccg ggtcggtgat ccaccggccg gaccgcaggc
     5341 cggggatgtc ggcggtgagt gcggtcgcgc cctgtcgggg tgcgaaggat gtcgagggca
     5401 tgacctggcg ggtggttccg gtgtggcttt gggtgccgtt gcggtgctgt tcccaccagg
     5461 cgatgacgac gtgcatgagt tccccctgag tgtcggttgt ggtgccggca cgatgtggtg
     5521 ccggcacggt ttcccttcga catccgtgcc cggctccggg cccgccggtc agagctgcga
     5581 acctccggtg gcgtcgagga cctgcccggt cacccagcgg gcgtcgtccg aggcgaggaa
     5641 ggccaccacg tcggccacgt cctcggggcg gcccacccgg ccgagggcgg agagctcggc
     5701 cgcggagcgt tcggcggcct cgttgccccg cagccaggag gcgttgatgt cggtgtcgat
     5761 gatgccgggc gcgacggagt tcacggtgat gccgcgaggg ccgagcgcct tggcgagggt
     5821 gaggctgaag gcgtcgatcg cccccttggt catggcgtac gcgatgatgt cggtcagggc
     5881 gatccgcgtc gcgccggagg agacgttgac gatccgcccg ccgtcgcgca gccgcttcag
     5941 cgcctgctgg gtgaggaaga acggcgcgcg catgttgacg gcgacggctt cctcgaatgc
     6001 ttcggccgtg gtctcgtcga tctcgccgcg cggagtgacg ccggcgttgt tcacgaggat
     6061 gtcgaggccg gtgctggtgg cgtgttccag tacctgccgg tcgaagctct cccagagggt
     6121 cgccacgtcc ccctcggctc ccagctcggc gtggaccgtg aaggcggtac cgcccttggc
     6181 gcggatgccc tcgacgacct cgtcggcggc cgcggcactg cgtccgtagt gcacggccac
     6241 cgtggcgccg tcggcggcga gccgctcggc gatcgcccgg ccgatgccgc ggctgcctcc
     6301 cgtcaccagt gccgtcctgc ccgtgagcgc acccatggtc tccctttctg ctcgtatgtg
     6361 tgctgcgcgt acagactttc tgtagcgctg actatggaaa cggtacatca ttttcttagc
     6421 gatcgctgta aaatttgtgc atgacgacga cgaagcgcgg ccggccacga ggtttcgacc
     6481 gtgacacggc actcgcgcag gccacttcac tgttctggca gcacggcttc gagggcacgt
     6541 ccatcgccga cctgacctcc gcgatgggga tctcgccacc gagcctctac gcggccttcg
     6601 gcgacaagcg cacgctcttc cacgaagtcg tcgagcggta cggcggcacg ttcggcgcct
     6661 tcatggacaa ggcgctcacc gaggagagcg acccgcgcag gggcttcgcg cggatgctgg
     6721 acgaggctgc tctggcctac accgatccct cgcatcccgc gggctgcctg gtcatcacag
     6781 ccgcgaccaa ctactccaaa cagaccgccg acatcgagcg ggacctgcgt gaacgccgca
     6841 gagcgaacgt acggtccttc gagacccgcc tggaggacgc ccggagccgg ggctcactcg
     6901 gccaggacac cgacacccgt gccctggccg tctatttcgc cgccgtggtc cagggcatgt
     6961 cgcagcaggc ccgtgacggc gccaccgcgc aggaactgcg ccgcgtggcc gagctcgcca
     7021 tgaccgtctg gccgccttcc ggcgcttcct cctgaagcac cggaccggga aggtgtgccg
     7081 gccgccggtg ccgcacgggc gggtcacggc gaccggccgg ctttcacaga gcgggcggtc
     7141 ccccgtccac gcggcacagc cgggacgcca cgtgcgcgta ccgctcgtcg aacttcaggg
     7201 tggtgaaggc gtggtcgagt tcgcgctcga gagtctccct ggcgcgtctc cacacggcga
     7261 ggccggcctc cgtgatggcg acgcggctgg tgcgccggtc gcacggccag gccactttgt
     7321 ccgtccagcc ggaccgttcg aggtgcgcga gcatgcggct ggccgccgag acgctcagcc
     7381 ccagtcgtcg ggcgacgtcg ctgacggtcg cgggcgtcga ctgctcgccg gccaggaccc
     7441 cgagcgccat cagctggccc agcccgacgt tgtggcggag cgtcagcact cggtccagcc
     7501 ggccctccag cagggagaac atggggacga cacgctccca gagccgggag acgttctccg
     7561 tttcggcgtc atggttttcg ttcgtgtacg gctctgccac gtaggtgcgg tccgtcctcg
     7621 ctcagccggg tgcggggcct ggggatgcgg gtgcggcggc ccggtcgccc tggggtgggc
     7681 ggtgtccgta cccggggggc tccggcgccg ggccccgctg tccgtgctcc ggcgcccgag
     7741 cttcgggaag tggtcggtca gggcaggagg aggagctttc ctcgtacgcc gcccgcctcc
     7801 agaagccggt gggcctcggc cgcgtcctcg aacccgagct gcttcgaggt gcgcagccgc
     7861 agcttcgagg cgtccaccag ggccgccatc tcggccaggc gggggccgtc ctgttccacg
     7921 tgggagacgg tcacgcggat gccgcgttcg gcggcgggga cccgggtcgg cacgatggag
     7981 accacgcgcc cgccgtcccg tacggcgctg atcgcgcccg gcaggccggc ggtctccagc
     8041 aggccgtcga cggttctcgg cgaaaggccc gcctcatcca ccacccggtc ggcgcccaga
     8101 gcccgggccg tgtcctcgtc ccgggcggac cgcacctgcg ccaccaccct ccagccgcgc
     8161 agcttggcga gctggaccgc catcccgccg accgccccca ccgcgccggt gaccagcagg
     8221 gtcgccccgg cgggcaggtc gaaggcgtcg agcgcctggg cgccggcgag tgatgccagc
     8281 ggcagacccg ccgcggtggt cagctccacc gtcctcgggg ccggggcgac gatgtccgcc
     8341 ggcagtgcga cggtctccgc gtacgtaccg cgcccggtcg ccatctgcgc cgacatcgcc
     8401 acgacccggt caccgggccg gaagcgggtg acctgctccc ccaccgcggt gacggtgccc
     8461 gccacgtccc agccgaggac catcggcggg cggaaggcgc tgtgcccggt gtgcaggccg
     8521 ccacgggtct ggaggtcgac cgggttgacc gcggcggcgg ccgtccggat gaggacgccg
     8581 tccgggtccg ggccggccgg ttccgcgatc tcggagaccg acagcccttc cgggccgccg
     8641 aacgacgtca gaactacagc acgcatgatg tgttcgcttt cctgaccggg gcggtgcacc
     8701 gcggacccgc cgcgccgcac cgccctgcga gcatcagacc agttcgggga tgcgggacgg
     8761 cagccggccg gtgacggagg cggtgagcgt ccgcaggacg agcagccggg tctgggctcc
     8821 ctcggcggtc aggcgggcct gcgcgccgtg cggcaggagc gccagttgcc cggcccggag
     8881 gactcgctcc gcggactccg tggtgagccg tagctcgccg ttgaggacga gcaccgcctc
     8941 ctccactccg tgttgcgggg tggaggccag cacgccgccg ggcggaagcc gccagtgctc
     9001 caccgcctcg cattcgctgt gcagcattcc ccggcgcacc aggcaggtcc acatggccgc
     9061 cgcgtccccg ccaccggtgc gtgggcccgt gcccgtggac gtgccggctt ccctctccgc
     9121 gccctggccc gtgtccgagg ggacggcgac tcgaacggcg tcgtcggtgg tagagatgat
     9181 cacgacgcct ccggcgcgga acgcgggacg gacagggtca cgaccagcag ccgcagcggg
     9241 gtgacggcct cgacgcccgt gacggtcgac gcgccgaggg tgaggcaggt gtcggaagcc
     9301 aggacggccg tgtggccgtc ggcggtggcc cggcccgtcc cctcgtgcac gaagacggcc
     9361 agttcggcgt ccggggctcc cagccgggtc cgctcgccgg cgtcgagttc gacgacctcc
     9421 acctgccgta gcgggccggt gaagacccca ctggtggaaa ccgtgcgctc tttgaagagg
     9481 tcgtggatga ctgcttcgcc catggggggt actcccgggt ggtggtgtgc ggctccggac
     9541 agaacggcgt cggtgccggg tgcgagggtc tcgatgaccc accagtcgag atcgtccttc
     9601 ccggtgttgc gcagcccgtg cacgttgccg ggggccgtca gggcgagcgt tccggggccg
     9661 gccgggtgcg gtcggccgtt gaacaggaat tcgccccttc ccctcaggac gaggtagatc
     9721 tcctcggtgc gggtgtggcg gtgctccccg ctgaggccgc ccgggggcac ggacgcccac
     9781 tcgacggcct cggtgggcga gtggagctgg cggcgtcccg cgaagcactt ccagcgggta
     9841 cgtccggcgg cgccgtgcac gccgtacacg gtcgcggcgc cggccacggt tccgagcgaa
     9901 cgccagggcg ccggggaggt ccgcggctca tggcacgcgg tacggccgga cgccgggtcc
     9961 gcggacggga ccgggccggg gcggacggcg gcttcggtgg tcaccgggag actccggagc
    10021 cgagggccgc cagcgactcg gccgcggcgg ccagttcacc ttccgtgacg tcgttgacga
    10081 agagcgcgct gccgatgccg acgggcagcg gcagtcgctg cttgccgtcg cggtgccgca
    10141 cggtgtcgcg cagggcgtcg ccgagcacct cgggcgtgca cagcgggtgc cagaccggca
    10201 gtcccaggcg cgccatcaca tcgaggacgc ggtcacgctg gtaggagctg accaggccgc
    10261 gccgctcggc cagcacggtg gtgagcgcca tgtcgacggc caccgcctcg ccgtgcagca
    10321 gcgcggggag cgcgtgcatc tcgatggtcg ggctgaaggt gtggccgtag tccacgactc
    10381 gctccagcac cttctcccac aggttgggct ggagttcctc cagcatgccc tggatggccc
    10441 gttcgacgac ctcggtcgcc gggtcgaggt gcagtccgcg ggcggcgagg cgctggtcca
    10501 ccggcgcgtc ggcgggggtg gggccgacgg ccgccgggct ctggagcttg ttccgcagga
    10561 ggtcggctcc gtgctgctcc agcaggtcga acaggcgggc gtccttgatc agggcgatct
    10621 tgaggatttc cgccaggccg ttgctgatgt gccgcgcgtc gagcgtggcc aggaaggagc
    10681 ggtcgagcag ggtgcggtcc gcggggaagt aggtgccgag ccggttcttg tggccgttgt
    10741 ggttgacccc ggtcttggcg ccgacacccg cgtccaccag gccgatcagc gtggtgggga
    10801 tccggatgaa cggggtggaa cggcggtaca ggctggccgc gaacccgacg atgtccatca
    10861 gcaccccgcc gccgatggcg atgacgggct cgcgccggcg gtcgatgccg aaggcgtcga
    10921 gggcctcggt gacctggagc accgcgtcca tggacttgtg ggtctcgccg tcgttcagga
    10981 ccagcacccg gtgctcgacg ccgtggtggt cgaagtaggc gcggacacgg tcgccgtaga
    11041 gcgagtcgac caccccgtcg gtgacgatga ggcggcgctg gccgctgctg cccgaggcgt
    11101 cctccaggat ggtggagttc ccggggtcga ggaggttctc gcaagcccgt atctcgtact
    11161 ggaccggatt gctggtctgt acggaccagt gggtgaccgg gctgcccacc gcgaagagac
    11221 cgtcgttgtt ccgcatggtc tgggtgtcct gctgcatcgg gcttccgcct ccgacgaaga
    11281 gtctgggttc gggttcgttg cgaatccggt cggggcagtg ttttcgggtc tccgcgcggc
    11341 aaggcctcct gggccgcctg cgcgggacgt ggccacggca tcgtggcctg ccccccgtcg
    11401 tcggggacga ccctgacaca cacatccttg cgtgcgcaag gacatgtccg ggtccgcgac
    11461 ggcgactcgg ccggaaagcg gcggcagggc gacgcggagg cctccgcaac ctggatcccg
    11521 ctcccgacgg cgcgttccgg gatggccgga agtgctcgcc cggtgcgggc ttccgcagga
    11581 gacagggggt ccctcccgcg gcccggcggc acccggccga ccggcacgcc tcacgggccg
    11641 acggggcctc ttcccggcgg aaaacgcccg tggccctcgc cggggggacg gcgagggcca
    11701 cgggcggacg gagcggggtg cggggccgcg cggtcgacgc ggctcaccgg tcgagtctcg
    11761 gggcgtaacg caaccgcgcg acgaccgaac tggtcctgtt gtccatggac gccacctcga
    11821 acgccatgcc gacctcgcgc cggaagaggc ctcctatctc cgcggccagg tcgcggccgg
    11881 cgtcggtgac gcgcaccacc acgcccctgc ggtcggtcgc gtgggccccc ttctccgcca
    11941 ggctccgcga ctccagacgc tgcacgaccc gggtggcgga cgactggttg aggcccagga
    12001 gttgggcgag ctcgttcatg cgcatgcctg acgggtcacc gttggcgagc gctctcaggg
    12061 cgaggaagtc cgtgaggccc agttcgtagt cctccgagag tcgccggtcc agcgcggtcc
    12121 cgacctccgc gaccaggacc gacagctggc tccacagctc gatgctgtct tccttgcgcg
    12181 ctcgcatgat gtcgacctct ccaaagtgcc gaggtttcca ccgcccgccg aaggggcctt
    12241 ccggccacgg tggggggtgg ggctcggtcc cgcgactgcg gggacggccg gaacacctcc
    12301 agggtaggag ggtcaggcag tcaagagaac cttcggtgac acacattttc catgcctgca
    12361 catggagatc ggacgctact tgaatcgagc agagttcgaa tctccccctc tgacactgaa
    12421 accgcagcgc actgccgctt cagcggggtc gccgggggtc ggaacaccgc aagacttcct
    12481 tgcgcacgca atgacattgc cttactgtcg ctgccgtccg gttcccggcc gcgaggcggc
    12541 ggggccgaca tccgagcatt cgtgcgccgc gtaccgaccc gtacccggtg tgccgtttca
    12601 aggggggaac atgctcaacg ccgtcccggc gtcgccgccg gtgcacaccg gcctgcccac
    12661 cgcccgcgcg gtggaccact acgccttcac ggtgccacgc ctcgacgagg ccgtcgccta
    12721 cgccgtcgac gtcctggggg gccggctgtg ctaccgggag gggcccgtcg aggacccctc
    12781 cggggactgg atgacccgca aactcggtgt ccacccacgg gcccgcgccc aggtcgccct
    12841 ggtccggctc ggtccctgca ccaacctcga gctcttcgag tacaccgccc ccgaccaact
    12901 cctcgccccg cccggcccga acgacgtcgg cggccaccac ctcgctctga cggtcgccga
    12961 tccggacgcg gccgaggacc acctgcgccg ggcgggcacc gtccgtctcg ggccggcggg
    13021 ccctcccggc acggcccacc gctggttcct gacgccctgg ggcatgctcc tgtcggtgcg
    13081 cgggccgctc aggcccgacg gacggcgttt cgtccccgcc cccgacccgc accccacggc
    13141 cgtacagagc gctctgggcc tgctgggcgt cgagcacgtc ggttacaccg tggccgacct
    13201 cgatgccggc gtcgccttct tcaccgacgt actcggcgcg gaagtggtgg agagcggggc
    13261 ggcacccgac accggtccgg acggacaccg gcctcccggc gccgagcagt cgcgacgggt
    13321 cctgctgcgc accgggccga ccgccaactg cgagctcgtc cagagcggga ccggcgccct
    13381 gcgctcccgg ccaccgcgca acagcgacat cggcggccac cacctggcct tctacgtcga
    13441 cgacgtggac gcggccgccg cgtacctgcg cgagcagcgg ggcgtggtgc tgatgggcga
    13501 accggagacc atcacccagg ggccgatcgc cggcgaccga tggctctact tcagcactcc
    13561 catcggcatt cagatggaga tcctcagcat gccggacgga tcactgccct acgagcggca
    13621 gaccacggcc cgccgtgcca cgccgggcag tctgcgctgg cacgaccgcc cctgacgacc
    13681 ggggcggcgg cccccgcgcg acggcgcccg cggctgtgcg ggcgtggcgg gccgcgcccc
    13741 ggcctcgtac gcgtccgccg agcatccgcc gcacgcggtg cgacgcgccc ggcggctccg
    13801 gccgcgtcgc gcaccaccgc gccctacgcc ccactcggac tcatcaggga acttcccatg
    13861 gacacgctca ccccgttacc ggtccggccg gccgggccac tgcgccgagc ggccgccgca
    13921 cgggtggcgc tctggctgga ccgccggcgc gccccggaac ccgacggccc gaccgcaggc
    13981 ccggtcctcg acctcgccgg ggcggccgat gccgtccagg acctgctgcc gcccgcctcc
    14041 gagaaccgct cctcgggaca gctcaccgcc cacggcatcc gcgtcgtcgg cccggtccac
    14101 ggaggggccg gccaccggcg gctgatgcgg cgactgctgt ccgaggtgtc ctccgcctcc
    14161 cccgccgcca ggcccaccgc catcgagtac tgcgtcccgg ccgtggacgc gctcgtcgac
    14221 gcccgcctgg atcaggtcgg cggctgggag gcgaaggcga tgcggtcccg tgcggggatc
    14281 gccggagccc acctgctgta cgacatgcac cgccgcgaac tcgcctcccc gcaatggacc
    14341 gaggccgtcg cccgcggcgc ggcggccccg cgtctgttgt ggtcgacgcg gccgggcgcc
    14401 ggcccggacc ggggcgccga cctcgcccgg cggctgctgc tccccgggac cgccgtggcg
    14461 ctgtcgcccc ggtccctgga atccttcgcg cgacacggtg tcgtcaccgg gccgaccgtg
    14521 cccgacctcg cggaggccca ccgcgtcgtc ggcgtcctcg actggttcgg catccgcctg
    14581 gacgacctgg actcccctgc cgggtgaccg tcgagcaccc gccgcaccac accgccggag
    14641 ggcggacgcc accgcgcgga cacctcccgg cgcacggccg tgatccggcc ccccgtttcc
    14701 tgccggcctc tcatccgaag gactttcact catgctttcc cctgcctccc tcccctcgga
    14761 cgcggacacg tccgccggac cggcgaccgc cgacgccgcc gggcgcccgg ccgcgcagac
    14821 cgcggtacgt ccccgggtgc accgccggag gttcctgtcc ggcacggccg cggcgggcgg
    14881 cgcgctcgcg gtgaccgccg ccgggctggg ctccgcggcc gcggcggaaa cggggcgcgg
    14941 cggccccctc gcgggttcgc ccgccggcgc ggcagcggcc cccgtcacgg tgcgcccggc
    15001 cgaccggcgc tacgccgatc tgcggcgcgg caccaatcag cgctgggtgg gcagccccga
    15061 gcacatcgtc ctggccacgt ccaccgccga cgtcgtgcgg gccgttcagc aggccgtcga
    15121 ctccggccgg cggctggcgg tacgcagcgg cggccactgc tacgagaact tcaccaccag
    15181 cgacgacata gcgatcctcc tcgacctgtc ccggatggac gacatcgcct acgacgagcg
    15241 ccgccgggcc ttctccgtgc agcccggcgc cgccctcggc cgggtctacg accggctcta
    15301 caagggatgg ggcgtctacc tcccggccgg gaactgcccc acggtggccg ccggcggcca
    15361 cataccaggc ggcggttacg gctccatgag ccgccgcgac ggtcttgccg tggaccatct
    15421 gtacggcgtc gagatcgtgg tcgtcggagc ggacggccgc gcccgcgcgg tcaccgcgac
    15481 ccgcgagccc ggcgatccga accgggagct gtggtgggcg cacacgggag gcggcggcgg
    15541 caacttcggt gtggtcaccc gctactggct gcgctccccg gacgcccgcg gcgacgatcc
    15601 cgcggcccag ctgcccgcac cgccacgcga ggtgtggctg agcgaggtcg cctggccgtg
    15661 ggaggaactg accgagtccc gcttcacccg gctgatgtgg aaccacggcg actggcacac
    15721 ccgcaacagc gcacccgact ccccgtacac ggcgctgttc agccagctca agccgttcca
    15781 caagtcgggc ggcgcggtgg tgctcgactc gctggtcgac gccgacgcgc ccggtgccga
    15841 gcgcctgctg cgcacctaca tcgccgaggt cggggcaggg atcggaatcc agccgcaggt
    15901 ccgccagtac cggcggatgc cgtggctgca cgccacccag tggccggggt tcaccggccc
    15961 cgacccgacg gtccggttca agggcaagtc ggtgtacgcg cgccgcacgt acaccgacgc
    16021 ccagatctcc gccgcctacc ggcacctgac ccgcgacgac ttccacaacc ccggcgcact
    16081 gctgatgatc gcctcgtacg gcggtgcggt gaaccgtgtc gcaccggacg ccaccgcggt
    16141 gccgcagcgg gactcggtac tgaagtacca ggtcgtctcg ttgtggcagg acgcggcgga
    16201 cgacgcggcc aacatcgcct gggtgcggga gtgctaccgc gacatgttcg cggcgaccgg
    16261 cggtgtgccg gtgccgaacg acaccaccga cggctgcttc gtcaactacg ccgacgtcga
    16321 cctcggggac ccgcgctgga acagctcggg cgtcccctgg cacgagctgt actacaaggg
    16381 cggctaccgg cggctgcaga aggtcaaggc cgcctgggac cccaccggct tcttccgcca
    16441 cgcccagtcg gtgcgccctg cctgacccgg cgcacccggc cgaccggcac gtcgctgcgc
    16501 ccacggcccg gacgtgccgg ccggctcccc tcctcgcccg cagacctaca ccgacgggaa
    16561 accctcgtgt ccactgcacc tactgtgccc gggcgctctc cccggctctc ctcactcacc
    16621 ggaatgcggt tcttcgccgc cttcctggtg ttcctcttcc acctgtcact gctcgacgcc
    16681 tactccaccc ccggtgaaca gcacggcccc ttcgcctccg cggtgaagaa cggcggctgg
    16741 gccggtgtca ccttcttctt catcctcagc ggcttcgtac tggcctggtc cgcgcgcgac
    16801 ggcgacacca cgacctcgtt ctggggacgc cggatcgtga agatcgcgcc caaccacgtc
    16861 gtcaccttct tcgtcgccct ggcctgctac gcctacgcgt cggcgacctg gggagcgggc
    16921 atccccaact tcctgctcct ccaggcgtgg gtaccgcgcg acgacgtgtt cttcagtatc
    16981 aacaacccca gctggtcgct ctcctgcgag ctggtcttct acctgctgtt ccccgcgctg
    17041 taccgcaggg tccgccggat ccgcgccgag cggctgtggt ggtgggccgg cggcacggcg
    17101 atggtgatca tctcgctgcc gctgctggta cagctgctgc ccgcgggtga gtcgttcgga
    17161 ccgaaccacg ccaactctcc gctgtacggc cattccatca cccagatgtg gctcgtctac
    17221 atctttccgc ccgcacgggt gctcgacttc ctgctcggca tcctgatggc ccggatcgtg
    17281 ctgaccggcc ggtgggtggg cctcggggtg ctgcccgcgc tggccgtcac gctgacggcc
    17341 tacgtgctga gcctccaggc gcccttcctg ttctccctga acgccgtcgt cgtcgtgccg
    17401 ttcgcgctgc tgatctccgc cgctgcggcc cgggacgcgc agggccgcgg caccgccgtc
    17461 ggcggacgcg tatgggtatg gctcggcgag gtgtcgttcg ccttctacct ggtccaccag
    17521 atcctgctgt ccgtactgca ggaacggttc gggtaccgcg agaccggctc gctcgccgag
    17581 gcggccggcg tggccgtgct gatcgccgcg gtgagcctgc tgctggcctg gctgctgtac
    17641 gccggcgtcg aacggcccgc cgtacgggcc tgggcgcgcc ggggccgtgc ccgtaccctc
    17701 cgcgtcgccc gtgaccagcc ctccgccgac ggtcccgggc ccgggagcga ggagagcgac
    17761 cggccggtca ccgtcggcac gccctgaccc gaccggaccc cggccgccgg gctctcccgg
    17821 ctcgcccccg gagagcccgg cggccacggg gccgacctca gaggagcttt catgccgctg
    17881 cccgtcctcg cgatgatgct gtgcactttc tgcatcggta ccgccgagag cgtcatcgca
    17941 ggcatcctgc cgggcatcgc gcaggacgtc ggcgtctcac tgaccgccgt cggcctgctg
    18001 atcaccgtgt acgccgccgc ggtcgtcctg gtcggccccc tggtcaccgc ggccaccgcc
    18061 acgctgcgcc gcgccacgct tctgcccgcc atgatgggcg tgttcgtcat gggcaacacg
    18121 ctgggcgcgt cggcacccgg cttcggctgg ctgctcgtgg gccgcgtggt gagcgcggtc
    18181 gtccactcca ccctgatcgc cgccttcgtg gccgccgccc gggacacggc gccaccggac
    18241 cggcgggccg cgtacggagc gaaggtcacc ctcggcatcg gcctgtccag tgtggccggg
    18301 gtgcccgccg gcaccctgat cgggaacgcg ttcggctggc gcgccacctt ctgggcactg
    18361 gccgcggtga gtctcgccgc caccgcgctg ctcacccggt ttcccgcacc ggaatccccg
    18421 aggggcacgg cgaagccggc cggcctgcgc cgaacggccg ctccggacac cggccccggc
    18481 cggcgccggt tcgtcctgcc gggcccgatg ctgctggtcg ccgcggtgat cacgctgggc
    18541 accgcgggag tcttcgccct ctacacctac gcctcgccgt acctcacgca atccgccggc
    18601 ttcggctccg ggagcgtcac cgtgctcctg ctgctgtacg ggctcggagg catcgtcggc
    18661 aacacggccg gcggccgggc agccgaccgg ttcccgtccg cggccgtccc cgcgaccctg
    18721 ggcgcggccg cggcgggtct gctcctgctc gcgctgcccc cgggcaaccg gtgggccgtg
    18781 gccggcgtct tctgcctgct gggcaccgcc tacttcgcga cgatccccgc cctcaacaac
    18841 gccatcgtgt ccgcggcggg cccgtcgtcc tccaccatgg cgttgaccgt caacaactcg
    18901 gcgttctgcg tgggcatcgc gctcggcagc tggctcggcg gcctcctgct ggcccgcggg
    18961 aacacgctgc cgaccgtggc cgcggccggt gcggcatcca ccgcggcggc cttgctgctg
    19021 gccctgctgc acacccgact ccgcaaggcc cctcccggac ccgccctccc cgccaccggc
    19081 gcatcccacg acactggcac cggcaccggc acgaccgtcg cgggcagcgg agtgccacgg
    19141 tgacgtgggg gcgcccgccc ccactggacg tggcagacct cgaaccatgc ccgcccggct
    19201 tgggcgcagt gcctcctcat ccggtacatg cgacaactgg ccgaagcgcg aggagcagca
    19261 gcgtgccgag cgtgccgccg gatccgcccg cctgcaggcc tggcaggctc tgcgcacctc
    19321 cccgtacgcc gagacgttcc atgccccggt gcgcttggcg acgccccgac aagccggcgg
    19381 tcatgcgaca gcgattcacc acgatccgcg ccggcctgcc catgccggcc tcgcagcacg
    19441 acggcttcga gccgaagccg cccagcaggc tccctcgaag ccgtcgtgct gcgcaccaag
    19501 cccgcaccct gcgtgcggtc gtcgagcagc tccaggccga gcaagggagt gcggcgccag
    19561 gccaacgccc aggatccggc gtcatacgaa cggcgaagca gcccgcaccg ccgtgctgca
    19621 gcaggagagg cggcagggcg gagcaccctg cgtgcccggc agacccgcga acagatcccg
    19681 caccagcgac cccgaagagc tcgtagattc gtgtcctgcc cgctggagct gggctgaccg
    19741 tggttgttcg ggggcatgat cggcaaagtc cgcacccgag tcctgccggc ctcccagcgc
    19801 cgctcgctgg acgagttgac cgaggacctg gacctgtcgt ccggggacac cacgtccagg
    19861 cgttcggcct tctggacgat gctgacgctg tcgtcggtca tcgcatccgg cggcgtgctc
    19921 acggactcga cggccaccgt gatcggcgcg atgatcatcg cgccgctgtc cacgcccatc
    19981 atgggcatcg ccctgggctc ggtgaagcgc cgccgcaccg gatcggccag ggtcgtcctc
    20041 ctggcgtgcc tgctggtgac cgcagtcggg atggccgtgt cggtggccct ccccggcgac
    20101 tacgacctgc tgtccaacag ccagatctcc tcacggacgt cgtcgggcct gatggacctg
    20161 atcgccgccc tggcgaccgg tttcgccggc gcagtggcac tggcccgccg ggacgtcgcc
    20221 gccgtgctgc ccggcgtcgc gatcgccatc tctcttgtcc cgcccctggt ggtggcaggg
    20281 gtgtgtctgg gacagctgtc gggatggctg gcgctggggg cgttggtgct gttcgtgtcg
    20341 aacctcttcg ccctggtctt cggcggcatg gtggtcttcg cctcgctcgg ctacggcacg
    20401 gaggccgaca aggcagccgg acgtcccgcc cgcaggacct acgcggccat gatcctgctg
    20461 ttcaccgccg tgttcgttcc gctgacggcc aacaccgtga tcacactcct gctcgacacg
    20521 tggaccggcc ggaccaagga cgcggcacag cagtggcttg ccgacgtgcc ggacgcgtcc
    20581 gtcacgagcg tcgacgcgac gtcgcggacg atgtacgtcc acgtccgcag ccccggagac
    20641 ctcccgccgg tggagtctct gctcgaccgg ctcgagggac ggatcccgga cggtatcccc
    20701 gtcgcggtgg acacgtcgcg tggccggcgc atcgacgccg gagtggtcgg cggctgagca
    20761 tcccgtgctg ttccccctcg gagcgccctg gtctgtttcc acgcggcctg ccgcaagcca
    20821 cggcggcccg ttcagcctgc tggagcctcc gtcgattccg gagcggttca cgccgcccgg
    20881 ctcggcgaag ccgggaggag gccgcagacc gaactcacgg aaagctcggt tgcgcgcatc
    20941 ctgccgatga cgttacggcg gcgcaggtcg cgtgcctccg catcgccgac ctgcgggatg
    21001 tgcaggtgcg gggcgatgcc ccggagttcc ggcttctcgc ggcccagggc gaccgcgtcg
    21061 tcggggaatg tgccgaacgg cagatgctgg taggcgtgat cggatccggc cagccgcggg
    21121 gggcgggcga tcggcatggg gttctccgtt cttgccgggg cgttcacttg ccgatgccgt
    21181 cggccaggcc cttgacgatg tagcgctggc cgaagaggaa caggagcacc acggggaccg
    21241 cggcgatcac catgccg
//
