LOCUS       NZ_BMTZ01000004        21086 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces variabilis strain JCM 4422 sequence04, whole genome
            shotgun sequence.
ACCESSION   NZ_BMTZ01000004
VERSION     NZ_BMTZ01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces variabilis
  ORGANISM  Streptomyces variabilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces griseoincarnatus
            group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 431607)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 156X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649935.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:37:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,743
            CDSs (total)                      :: 6,668
            Genes (coding)                    :: 6,496
            CDSs (with protein)               :: 6,496
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 172
            CDSs (without protein)            :: 172
            Pseudo Genes (ambiguous residues) :: 0 of 172
            Pseudo Genes (frameshifted)       :: 61 of 172
            Pseudo Genes (incomplete)         :: 147 of 172
            Pseudo Genes (internal stop)      :: 11 of 172
            Pseudo Genes (multiple problems)  :: 42 of 172
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:23:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 195963
            Orig. end                         :: 217049
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMTZ01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11086)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    9..24
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.17"
                     /tool="antismash"
     gene            159..923
                     /locus_tag="IE148_RS09325"
                     /old_locus_tag="GCM10010287_18690"
     CDS             159..923
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="IE148_RS09325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18690"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_086701685.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEGGTAVRTARVPKYYRLKKHLLDMTETAPPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRA
                     QGLEPTSQLLDLGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRF
                     PALRRSLTKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRH
                     SLDRDGQPVEWVRSVYRGDRYKFVARLKRPQD"
     gene            1172..1393
                     /locus_tag="IE148_RS09330"
                     /old_locus_tag="GCM10010287_18700"
     CDS             1172..1393
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522900.1"
                     /locus_tag="IE148_RS09330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18700"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_086701687.1"
                     /transl_table=11
                     /translation="MRVVIGLCLLAPFVAMLWVGSYAKTDPVVIGIPFFYWYQMLWVLI
                     STVLTMIAYKLWQRDQRARSATKGGAEQ"
     gene            1390..3018
                     /gene="mctP"
                     /locus_tag="IE148_RS09335"
                     /old_locus_tag="GCM10010287_18710"
     CDS             1390..3018
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006848 - pyruvate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mctP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="IE148_RS09335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18710"
                     /product="monocarboxylate uptake permease MctP"
                     /protein_id="WP_048455692.1"
                     /transl_table=11
                     /translation="MNDGVNGVALAVFLFFFVLVTVMGFLAARWRKAANEHTLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     ENTNWFIKDLPLLLAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDEIFASAQEAYSETNPATGAPRGSLVPGEAGQWTYATLALGSALALFMYPHSITATLS
                     SRSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGVKVQNGQLAIPQLFENMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPKQETAVSKVVSLLVKVGAL
                     AFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALIGGWAVGMIYGTVAAY
                     GVASPTQKHFGGSAKEIPGIGEIGYIGLTAFVINVLVTVVLTFVMRAVKAPEGVDETEP
                     RDYTADAGDPGVQVELPPATAGSAH"
     gene            3098..3601
                     /locus_tag="IE148_RS09340"
                     /old_locus_tag="GCM10010287_18720"
     CDS             3098..3601
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326961.1"
                     /locus_tag="IE148_RS09340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18720"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_189364233.1"
                     /transl_table=11
                     /translation="MDIVIRPATPGEHAELGEITAQAYLGDGLLDFGESDTYLGELRDV
                     GKRAAAAEVLVAVADGTLLGGVTFVPGPGPMADIAEPGEAEMRMLAVSPAHRGRGAGEA
                     LVRACADRARALSRTRMVLSTQRTMHSAHRVYERLGFTRAPGRDWNPLPELDDIMLLVY
                     ELTL"
     misc_feature    3649..3663
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.31"
                     /tool="antismash"
     regulatory      3654..3822
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    3680..3694
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    3688..3701
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     misc_feature    complement(3885..3896)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            3947..6304
                     /locus_tag="IE148_RS09345"
                     /old_locus_tag="GCM10010287_18730"
     CDS             3947..6304
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444560.1"
                     /locus_tag="IE148_RS09345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18730"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_086701689.1"
                     /transl_table=11
                     /translation="MTIAPADPASATRVTEESDGPGAALLRTLTQLTADLPDTDAGRVA
                     AAALRGRSAAADEAELRDLATEAAAGLISEDPAYSRLAARLLTLGIRAEAASQGVTSFT
                     GSVAAGHREGLIGDRTAAFVRLHAARLDALVDADADDRFGYFGLRTLHSRYLLRHPVTR
                     KVVETPQHFLLRVACGLAEDESERALEDVAALYGLMSRLDYLPSSPTLFNSGTRHPQMS
                     SCYLLDSPKDELDSLYERYHQVARLSKHAGGIGLSFSRVRARGSLIRGTNGHSNGIVPF
                     LKTLDASVAAVNQGGRRKGAAAVYLETWHADIEEFLELRDNTGEDARRTHNLNLAHWVP
                     DEFMRRVADDAQWSLFSPVDVPELADLWGEEFDAAYRAAEAKGLARRTLPARELYGRMM
                     RTLAQTGNGWMTFKDTANRTANQTAEPGHVVHSSNLCTEILEVTDDGETAVCNLGSVNL
                     AAFAGPDGMDWERLDAAVRTAVTFLDRVVDINFYPTEEASRSNSRWRPVGLGVMGLQDV
                     FFRLRMPFDSPEAKALSTRIAERIMLAAYETSAGLAERHGPLPAWERTRTARGVLHPDH
                     YGVELAWPERWEALRTRIAATGLRNALLLAIAPTATIASIAGVYECIEPQVSNLFKRET
                     LSGEFLQVNSYLVEDLKRLGVWDARTREALREANGSVQDFAWIPEDVRRLYRTAWEIPQ
                     RGLIDLAAARTPFLDQAQSLNLFLETPTIGKLSSMYAYAWKQGLKTTYYLRSRPATRIA
                     RAARAAVPVQQPADPEAVACSLENPESCEACQ"
     gene            6361..7317
                     /locus_tag="IE148_RS09350"
                     /old_locus_tag="GCM10010287_18740"
     CDS             6361..7317
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142309.1"
                     /locus_tag="IE148_RS09350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18740"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_233230340.1"
                     /transl_table=11
                     /translation="MRYPDFYERYRDAIKNTWHVEEVDLHSDVADLAKLTPEEQHLIGR
                     LVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEEAVHVQFYLTLLDTYLPDPD
                     DRAAAFAAVENIPSIREKAEFCFRWMDSVEEIDRLESKADRRRFLLNLICFAACIEGLF
                     FYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFDVVDTVRKEEPELFDEELGR
                     QVTDMLREAVEAELQFARDLCGDGLPGMNTASMRQYLECVADQRLVRLGFAPVYGSENP
                     FSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(7337..7558)
                     /locus_tag="IE148_RS09355"
                     /old_locus_tag="GCM10010287_18750"
     CDS             complement(7337..7558)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700023.1"
                     /locus_tag="IE148_RS09355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18750"
                     /product="hypothetical protein"
                     /protein_id="WP_063837933.1"
                     /transl_table=11
                     /translation="MNTTQTEALIAMVAVLGLFVLMVAPAVIGILRDRRIDRQIRRAEA
                     APVTEPPDTRAASRPEHRAASHHHARAA"
     gene            7652..8614
                     /locus_tag="IE148_RS09360"
                     /old_locus_tag="GCM10010287_18760"
     CDS             7652..8614
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700022.1"
                     /locus_tag="IE148_RS09360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18760"
                     /product="GlxA family transcriptional regulator"
                     /protein_id="WP_086701691.1"
                     /transl_table=11
                     /translation="MLRNVAAVLLDGVNPFELGVVCEVFGIDRSDDGLPVYDFAVASAE
                     GPAVRTSTGFTLQTEYGPERLETADLITVPAGASYAAREFPPEMLDALRRAVDRGARVL
                     SVCSGVFVLAAAGLLEGRRAAVHWKHAEELSRRYPHLTVEPDVLYVDEDPVITSAGTAA
                     GIDACLHLVRKEQGPEVANRIARRMVVPPHRDGGQAQYIERPLPEPGGDSVAGVLVWME
                     QHLDEEVTVEQLAARALMSPRTFARRFQQETGTTPYRWILRQRVLLAQHLLERTDETVD
                     AIAGRTGFGNAAALRHHFVRAVGTTPQSYRRAFRGPEAA"
     gene            complement(8637..10004)
                     /locus_tag="IE148_RS09365"
                     /old_locus_tag="GCM10010287_18770"
     CDS             complement(8637..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190553.1"
                     /locus_tag="IE148_RS09365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18770"
                     /product="cytochrome P450"
                     /protein_id="WP_086701692.1"
                     /sec_met_domain="p450 (E-value: 1.4e-71, bitscore: 236.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVRPEDATTTAEPPVAGGAVPLLGHGWRLVRDPLAFLSRLR
                     DHGDVVRLKLGPKTVYAVTTPALTGAVALSPDYIIAGPLWESLESLLGKEGVATANGTL
                     HRRQRRTIQPAFRLDAIPAYGPIMAEEAYALVERWRDAGGVLDITYESFRVAVRVAARC
                     LMRGGYMDAHADRICADLTTLFAGMYQRMVVPLGPLYKVPLPANREFNRALADLHVLVD
                     EIVADRRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVIAILTPGAETVGSTVMSLL
                     LVLTEHPELGDKIRDEVKSVVGDRRVAFDDVRRLTYTANVVTETLRLYPAVWILTRRAV
                     ADTELGGYRIPKGADLIYSPYAIQRDRRSYERNEDFDPDRWLPERSKDVPKYAMSPFSV
                     GNRKCPSDHFSMAELTLITAVVAHAYRFEQAPDSDPRPRIGITLRPRRLMLRARPR"
     gene            complement(10001..11086)
                     /gene="cyc1"
                     /locus_tag="IE148_RS09370"
                     /old_locus_tag="GCM10010287_18780"
     CDS             complement(10001..11086)
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="IE148_RS09370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18780"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_086701717.1"
                     /sec_met_domain="T1TS (E-value: 3.3e-66, bitscore: 219.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHALSHGSTSTPTTIAVPPALSLPVIEAAFPRQLHPYWPKLQRET
                     RAWLLEKRLMTPEKVEEYADGLCYTDLMAGYYIGAPDDVLQAIADYSAWFFVWDDRHDR
                     DIVHGRPEAWRLLKDLLHSALDRPGDHLGHTDPVVAGLADSVRRLHAFLPDTWNARFSR
                     HFHAVIEAYDREFHNRTEGIVPTVEEYLELRRLTFAHRIWTDLLEPSAGYELPDAVRKN
                     PAYRKPALLSQEFAAWYNDLCSLPKEIAGNEVHNLGISLVTHEGMTLEEAIADVRRRVE
                     ECISEFLDAEQEALRFADRLDDGTVGGKETSAAVRACVGNMRNWFSSVYWFHHESGRYR
                     VDSWDDRSTPPYVDNATEGEK"
     misc_feature    complement(10202..10204)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11207..11222
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.68"
                     /tool="antismash"
     gene            complement(11303..11953)
                     /gene="def"
                     /locus_tag="IE148_RS09375"
                     /old_locus_tag="GCM10010287_18790"
     CDS             complement(11303..11953)
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="IE148_RS09375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18790"
                     /product="peptide deformylase"
                     /protein_id="WP_086701694.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDEGYVIDTEDCEKREAKWRERGTSRPIT
                     VVGNPVLHKECKDVTDFGEEFQQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCPDD
                     EGLRHVGVVCNPKLVELPAEKRRLDDSSEGCLSVPTAYAPLPRPDYAEVTGQDEKGNPI
                     RVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKAALKQMAENEPRYPVVAND"
     gene            complement(12076..13056)
                     /locus_tag="IE148_RS09380"
                     /old_locus_tag="GCM10010287_18800"
     CDS             complement(12076..13056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="IE148_RS09380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18800"
                     /product="tetratricopeptide repeat domain-containing
                     protein"
                     /protein_id="WP_048455762.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRDTGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGPATDSGEPLGMDLGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERSTAAGHTYPVFDEIELWAPSPVPTWVVLLEAASEADRD
                     ALEQLASDAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGIAAPAALVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            complement(13213..14475)
                     /locus_tag="IE148_RS09385"
                     /old_locus_tag="GCM10010287_18810"
     CDS             complement(13213..14475)
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522889.1"
                     /locus_tag="IE148_RS09385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18810"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_189364234.1"
                     /transl_table=11
                     /translation="MRPRAHTVPLHTVVHLCAAVLAAGSLGTTLYHGVEDRSVALAFGT
                     LVAVGELTRRGGRGIREPAPVATAGSLAYALLGEVAGRPAGHGAAQVVTVVLAASLLGS
                     VPHVGRGDGPALDPVTRRVLTVGFVAVCFHPLHARGAFDDFSGPGHALLLLVLLTLTAL
                     CDAVLAAALAHSRTGWPFPPLLRDELRSVPGIGAAVVATGAVMALGAAVVGLWALPVFS
                     VPLLLAQLSHRRYTAVRATYRQTIASLARATEIAGCTPHGHSRRVAALSQAVGRDLGLT
                     EPELTVLEYAALMHDIGQLSLVDPVPEGATAGLPPAEQRRIALLGGAVVRQTGVDPRVA
                     GIVERQADPHAEQPLAARIVRVVNAYDEKCREGGPGGPLTALEELRLKAAGEYAPEVVE
                     ALARVLSRDTEGTREQMDRSW"
     gene            complement(14472..15851)
                     /locus_tag="IE148_RS09390"
                     /old_locus_tag="GCM10010287_18820"
     CDS             complement(14472..15851)
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006134738.1"
                     /locus_tag="IE148_RS09390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18820"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_189364235.1"
                     /transl_table=11
                     /translation="MEALPARARVYLVGVTLLGLCCLLPLTGVPRPGVLSSLPDPRVPW
                     WPVVLLAALYAGCERLARSRLVAGPHPGGTFHPVLLAGAFLLPPTAAALVALPGALLLP
                     VEHGPRLARRLWRTGRLVVAVWAAGLVHLKTGGRDAVAHCDMPGALATAGAAVLAFCLV
                     LTLLDGGVLVPAPGGLRRGRPVAAWWRLFLGSLAPLTVHGLAGLMMALLWRSPYGPVAA
                     LLVLLPMGVSWWAFAQYHRERAAHQATIRALVQAVDIKDGYTRGHSERVGRASMLIARE
                     LGMDDERVETLRFAGILHDVGKLGVPTRLLTKNGPLTPEERRVIELHPEYGHEMVRGIS
                     FLGEARAAVLHHHERLDGTGYPYGLAGGQIPESARVVAVADAFDAMTSTRSYSRARPVP
                     VALEELERCAGTHFDPRMVKALVTAIGRTGWHPAVTADEPRRTAVPGPAGHVTGRPGAR
                     R"
     misc_feature    complement(15840..15842)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15993..16295)
                     /gene="rsrA"
                     /locus_tag="IE148_RS09395"
                     /old_locus_tag="GCM10010287_18830"
     CDS             complement(15993..16295)
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326971.1"
                     /locus_tag="IE148_RS09395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18830"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_048455700.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEILDHLYEFLDREMPDADCRKFEHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPGDLRSKVMGRIDLIRSGQNVPEQDVTTAPQES"
     gene            complement(16292..16978)
                     /gene="sigR"
                     /locus_tag="IE148_RS09400"
                     /old_locus_tag="GCM10010287_18840"
     CDS             complement(16292..16978)
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="IE148_RS09400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18840"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_033272060.1"
                     /transl_table=11
                     /translation="MGPVPGTDAGTEHGQAEQPEGQGDTRAESTAERSARFERDALEFL
                     DQMYSAALRMTRNPADAEDLVQETYAKAYGSFHQFREGTNLKAWLYRILTNTFINSYRK
                     KQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEFRIA
                     VYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGESNE
                     AKGSGS"
     misc_feature    complement(16941..16956)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.19"
                     /tool="antismash"
     misc_feature    17034..17048
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.77"
                     /tool="antismash"
     gene            complement(17238..17903)
                     /locus_tag="IE148_RS09405"
                     /old_locus_tag="GCM10010287_18850"
     CDS             complement(17238..17903)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674889.1"
                     /locus_tag="IE148_RS09405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18850"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_189364236.1"
                     /transl_table=11
                     /translation="MTPESEATSESDVTTETITTDAGDARITWHHAGRPRLVLAVSHGA
                     GGGIEARDLAALAAVLPAHGVTVALVEQPWRVAGKKVAPAPKTLDTGWRGVWPALTRPG
                     LPVVSGGRSAGARVACRTAVELGAHAVLALSFPLHPPGKPEKSRAGELLGAGVPTLVVQ
                     GGNDPFGKPAEFPEGDHELVEVERADHGFAVPRRADLTQEEALHVITDAVVRWTAGLR"
     gene            complement(17959..18774)
                     /locus_tag="IE148_RS09410"
                     /old_locus_tag="GCM10010287_18860"
     CDS             complement(17959..18774)
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="IE148_RS09410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18860"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_189364237.1"
                     /transl_table=11
                     /translation="MCGRYAASRRPEDLAGIFEVEKWEPEETLEADYNVAPTKEVYAVL
                     DRPLKDADDPRPVRQLRTLKWGLVPSWSKTPEGGARMINARAETVHEKPSYRRAFASRR
                     CILPADGYYEWVTGKQERDLEVEGKKTRPRKQPYFVTPADGSVFAMAGLYEFWRDRTLP
                     DDHPRAWWVTCSVITTEAETSPLAVAPADGPHTLAEIHPRMPLMLTPDRWDAWLDPSRT
                     DPEDLRGLLAPPEPGLMRAYPVTTAVSNVRNNGPELLKELAAPEEGTLF"
     gene            18835..19557
                     /locus_tag="IE148_RS09415"
                     /old_locus_tag="GCM10010287_18870"
     CDS             18835..19557
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992842.1"
                     /locus_tag="IE148_RS09415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18870"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_086701721.1"
                     /transl_table=11
                     /translation="MVSTASASLASLWDEVAGTQPDPDLWVVVATLVAALAVVVPQAPW
                     RVARNAITIAHEGGHGLVALLTGRTLTGIRLHSDTSGLTLSRGKPTGIGMILTAAAGYT
                     APPLLGLGGAALLGAGRITLLLWLATALLLAVLVMIRNAYGAVSVLVTGGTFVLVSWLA
                     GPQVQAAFAYAVVWFLLLGGVRPAFELQAKRRHGGAGDSDADQLSRLTHVPAGLWLFLF
                     HAVSVCSLLGGGRWLLGL"
     gene            19644..20960
                     /gene="aroA"
                     /locus_tag="IE148_RS09420"
                     /old_locus_tag="GCM10010287_18880"
     CDS             19644..20960
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522882.1"
                     /locus_tag="IE148_RS09420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_18880"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_086701696.1"
                     /transl_table=11
                     /translation="MAPNPTHTALWPAPHASGAVDATVHVPGSKSVTNRALVLAALASE
                     PGWLRRPLRSRDTLLMAGGLRAMGVEIEEGVGPDGTGEAWRVVPAGLRGPATVDVGNAG
                     TVMRFLPPVATLAEGPVRFDGDPRSYERPLNGVIDALRRLGARIDDDDRGALPMTVHGG
                     GALDGGTVEVDASSSSQFVSALLLSAPRFNQGVEVRHTGATLPSMPHIRMTVDMLRAVG
                     AQVDTPESGGEPNVWRVTPGALLGRDLTIEPDLSNAQPFLAAALITGGRVVIPDWPART
                     TQPGDRLREIFTEMGGSCELTEYGLVFTGSGAVHGIDVDLGEVGELTPGIAAVAALADS
                     PSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGVFHTYEDHRM
                     ATAGAIIGLAVDGVQIENVATTAKTLPDFPELWTGMLGA"
ORIGIN
        1 ccaccgcccg tggtctggac catcactggt cacaggggta tacaaaaggg atcacggagc
       61 gcgcgagggg ccgtcccccg cccggagccg tgccacgatg tcagccgcgg ccgacggtct
      121 gtcggccgct tcggcagccg gagccgggaa ggcagagcat gagcaccgac gtcagcagtg
      181 cggagaacga gggtgggacc gcggtccgta cggcgcgcgt gcccaagtac taccggctga
      241 agaaacacct gctcgacatg accgagaccg cgccccccgg cacgccggtc ccgcccgagc
      301 gcaccctggc ggccgagttc gacacctccc gcaccaccgt gcgccaggcg ctccaggaac
      361 tggtggtcga gggccgtctg gagcggatcc agggcaaggg caccttcgtc gccaagccca
      421 aggtgtccca ggcgctccag ctcacctcgt acaccgagga catgcgcgcg cagggtctgg
      481 agccgacctc gcagctcctc gacctcgggt acatcacggc cgacgaccgg ctggccggcc
      541 tgctcgacat caccgccggc ggccgcgtgc tgcgcatcga gcggctgcgc atggccaacg
      601 gcgagcccat ggccatcgag accacccacc tcagcgccaa acgcttcccg gcgctgcgcc
      661 gcagcctgac caagtacacc tccctctaca cggccctcgc cgaggtgtac gacgtccatc
      721 tcgcggaggc cgaggagacc atcgagacgt ccctggccac gccacgcgag gcgggcctgc
      781 tcggcaccga cgtgggcctg ccgatgctga tgctgtcccg gcactcgctg gaccgggacg
      841 ggcagcccgt ggagtgggtg cggtcggtgt accggggcga ccggtacaag ttcgtcgcgc
      901 gcctcaagcg cccccaggac tgagaccgta cggccgcggg acggcgcgcc gcgcgaccgc
      961 atatcccgac agagcgggtg gttgacagga ttttcgttgc tgttgccttg cggttgcgct
     1021 gctgctgcat accgcccctc ttacgggggg ttacgaccgc cccgcaccct cacctacatt
     1081 gccgcgagcc aacgtcggcg atcagtgagg ggacgggagc cgtctgatgt cgcacagccc
     1141 gcaaacaaca ccagggccgg tggtgacgcc catgcgcgtc gtcatcggcc tctgtctgct
     1201 cgcaccattc gtcgccatgc tctgggtcgg gtcctacgcc aagaccgacc cggtggtcat
     1261 cggcatcccg ttcttctact ggtaccagat gctgtgggtg ctgatctcga ccgtgctgac
     1321 gatgatcgcg tacaagctct ggcagcgtga ccagcgcgcc cgctcggcca cgaagggcgg
     1381 tgcggagcag tgaacgacgg cgtgaacggc gtggcactcg ccgtcttcct cttcttcttc
     1441 gtgctcgtca ccgtgatggg cttcctggcc gcgcgctggc gcaaggcggc gaacgagcac
     1501 acccttgacg aatggggcct gggcgggcgg tcgttcggca cctgggtcac ctggttcctg
     1561 ctcggcggcg acctgtacac cgcgtacacc ttcgtggccg tcccggcggc catctacgcg
     1621 gcgggcgcgg ccggcttctt cgcggtgccg tacacgatcc tcgtgtaccc gctgatcttc
     1681 accttcctgc cccggctgtg gtcggtgtcg cacaagcacg gttatgtgac gacctccgac
     1741 ttcgtacgcg ggcggttcgg ctcgaagggg ctgtcgctgg ccgtcgcggt caccggcatc
     1801 ctggcgacga tgccgtacat cgcgctgcag ctggtcggca tccaggccgt gctggacgtg
     1861 atgggcgtcg gcggcggcga gaacaccaac tggttcatca aggacctgcc gctgctcctc
     1921 gccttcggtg tgctggccgc gtacacctac tcgtcggggc tgcgggcgcc cgcgctgatc
     1981 gcgttcgtca aggacacgct gatctacatc gtgatcgcgg tggcgatcat ctacatcccg
     2041 atcaagctgg gcgggttcga cgagatcttc gcctccgcgc aggaggcgta cagcgagacc
     2101 aacccggcca cgggcgcgcc gcgcggctcg ctggtgccgg gcgaggcggg ccagtggacg
     2161 tacgccacgc tggcgctggg ttcggcgctc gcgctgttca tgtacccgca ctcgatcacc
     2221 gcgacgctgt cctcgcgcag ccgtgaggtg atccgccgca acaccacgat cctgccgctg
     2281 tactcgctga tgctgggcct gctggcgctg ctcgggttca tggcgatcgc ggccggggtg
     2341 aaggtgcaga acggccagct ggccatcccg cagctgttcg agaacatgtt cccggactgg
     2401 ttcgccggtg tggccttcgc ggcgatcggc atcggcgcgc tggtgccggc ggcgatcatg
     2461 tcgatcgcgg cggcgaacct gttcacccgc aacatctaca aggacttcat caagccggac
     2521 gcgacgccca agcaggagac cgcggtctcc aaggtcgtgt ccctgctggt gaaggtgggc
     2581 gcgctggcct tcgtcctgac catggacaag accgtcgcga tcaacttcca gctgctgggc
     2641 ggcatctgga tcctgcagac cttcccggcg ctggtgggcg gcctgttcac ccgctggttc
     2701 caccgctggg cgctgatcgg cggctgggcg gtcggcatga tctacggcac ggtcgccgcg
     2761 tacggggtgg cgtcgccgac gcagaagcac ttcggcggct ccgccaagga gatcccgggc
     2821 atcggggaga tcggctacat cggtctcacc gccttcgtga tcaacgtgct ggtcacggtc
     2881 gtcctgacct tcgtcatgcg ggcggtcaag gcgccggagg gcgtcgacga gaccgagccg
     2941 cgggactaca cggcggacgc cggcgacccg ggcgtgcagg tcgagcttcc gccggccacg
     3001 gcgggcagcg cgcactgacg ccgtcgcgca cagggcagcg ggccgccggt ggaaaaccgg
     3061 cggcccgctg tcgttcccgt acggcagact cccccgcatg gacatcgtca tccggccggc
     3121 gacgcccggc gagcacgcgg aactcggtga gatcaccgcg caggcctatc tcggcgacgg
     3181 actgctggac ttcggggagt ccgacaccta cctgggcgag ctgcgggacg tgggcaaacg
     3241 ggcggcggcc gccgaggttc tggtcgccgt ggcggacggc acgctgctgg gcggggtgac
     3301 cttcgtgccg ggccccggtc ccatggccga catcgcggag cccggcgagg ccgagatgcg
     3361 gatgctggcc gtctcccccg cccaccgcgg ccggggcgcc ggcgaggcac tggtgcgcgc
     3421 ctgtgccgac cgggcgcgag cactcagccg cacgcggatg gtcctgtcca cgcagcgcac
     3481 gatgcactcc gcgcaccggg tctacgagcg gctgggcttc acgcgcgccc ccgggcggga
     3541 ctggaacccg ctgccggagt tggacgacat catgctgctc gtctacgaac tgaccctctg
     3601 acggctccgc acggcccttc cgcccggccg caccctcacc ccagcgcgac acaacatatg
     3661 ggcctgtcgg cgacacccga cacaagatgt atgctcatgc tcgctgtcgc cgcaggggaa
     3721 tccggtgcga atccggaact gtcccgcaac ggtgtaccca tgcctgccca cgggcgcgca
     3781 cgggagtcag tccgaggacc tgccgacagt gcgcccggcc cttccggtcc gggtgccctg
     3841 acgtccgggc ctcgcggaat gggccggtgg acgcgacgcc gcgtgcgttc gtgtgctgcc
     3901 ccctgcgctc ttcgaggccc ccgtgccgag cgagggagag ccacacgtga ccatcgcgcc
     3961 agccgatccg gcttcagcga cccgcgtgac cgaggagagc gacggccccg gggccgcgct
     4021 gctgcggacc ctgacccagc tgaccgccga cctgcccgac accgacgccg gccgggtggc
     4081 cgccgccgcg ctgcgcggcc ggtccgccgc cgccgacgag gcggagctgc gggacctggc
     4141 caccgaggcg gcggccgggc tgatttccga ggaccccgcc tactcccggc tcgccgcccg
     4201 gctgctcacc ctcggcatcc gcgccgaagc cgcctcgcag ggcgtcacct cgttcaccgg
     4261 ctcggtggcc gccggtcacc gggagggcct gatcggcgac cgcaccgccg cgttcgtccg
     4321 gctccacgcg gcccggctgg acgcgctggt cgacgcggac gccgacgacc ggttcggcta
     4381 cttcggcctg cgcaccctgc acagccgcta cctgctgcgc cacccggtca cccgcaaggt
     4441 cgtcgagacc ccccagcact tcctgctgcg ggtcgcctgc gggctcgccg aggacgagag
     4501 cgagcgggcg ctggaggacg tcgccgcgct gtacgggctg atgagccggc tggactacct
     4561 gccctcctcc cccacgctgt tcaactccgg cacccgccac ccgcagatgt cgtcctgcta
     4621 cctcctggac tcccccaagg acgagctgga ctccctctac gagcgctacc accaggtcgc
     4681 ccgcctctcg aagcacgcgg gcggcatcgg cctgtccttc tcccgcgtcc gcgcccgggg
     4741 ttcgctgatc cgcggcacca acgggcactc caacggcatc gtcccgttcc tgaagacgct
     4801 ggacgcgtcg gtcgccgccg tgaaccaggg cggtcggcgc aagggcgccg ccgcggtcta
     4861 cctggagacc tggcacgcgg acatcgagga gttcctcgag ctgcgcgaca acaccggtga
     4921 ggacgcccgc cgtacgcaca acctgaacct ggcgcactgg gtgccggacg agttcatgcg
     4981 ccgggtcgcc gacgacgcgc agtggtcgct gttctccccg gtggacgtgc ccgagctggc
     5041 cgacctgtgg ggtgaggagt tcgacgccgc ctaccgggcc gccgaggcga agggcctggc
     5101 ccgcaggacg cttccggcgc gcgagctgta cggccggatg atgcgcaccc tcgcccagac
     5161 cggcaacggc tggatgacct tcaaggacac cgccaaccgc accgccaacc agaccgccga
     5221 gccgggccac gtcgtccact cctccaacct gtgcacggag atcctggagg tcaccgacga
     5281 cggggagacg gcggtctgca acctcggttc ggtcaacctc gcggccttcg ccggcccgga
     5341 cggcatggac tgggagcgcc tggacgcggc ggtccgcacc gccgtgacgt tcctggaccg
     5401 ggtggtcgac atcaacttct acccgaccga ggaggcgtcc cggtccaaca gccgatggcg
     5461 ccctgtgggc ctgggcgtga tggggctgca ggacgtgttc ttccggctgc ggatgccgtt
     5521 cgactccccc gaggcgaagg cgctgtccac ccggatcgcc gagcgcatca tgctcgccgc
     5581 gtacgagacg tccgccggtc tggccgagcg gcacggcccg ctgcccgcct gggagaggac
     5641 ccgcaccgcg cggggcgtgc tgcaccccga ccactacggc gtcgagctcg cctggccgga
     5701 gcgctgggag gcgctgcgga cccggatcgc cgcgacgggc ctgcgcaacg cgctgctgct
     5761 ggcgatcgcg cccaccgcga ccatcgcgtc gatcgcgggc gtgtacgagt gcatcgagcc
     5821 gcaggtgtcc aacctgttca agcgcgagac gctgtccggg gagttcctcc aggtcaactc
     5881 gtacctggtg gaggacctca agcggctcgg cgtgtgggac gcgcgcaccc gtgaggcgct
     5941 gcgcgaggcg aacggctcgg tgcaggactt cgcgtggatc cccgaggacg tacggcggct
     6001 gtaccgcacg gcgtgggaga tcccgcagcg cggcctgatc gacctggccg ccgccaggac
     6061 cccgttcctc gaccaggcgc agtcgctcaa cctgttcctg gagacgccga ccatcgggaa
     6121 gctctcctcg atgtacgcct acgcctggaa gcaggggctc aagaccacct actacctgcg
     6181 ctcccgtccg gcgacccgga tcgcccgcgc ggcccgcgcc gccgtccccg tccagcagcc
     6241 ggccgacccc gaggccgtcg cctgctccct cgagaacccc gaatcctgcg aggcctgcca
     6301 gtgaccacca gcacgaccaa gaacctgctc gaccccggct tcgagctgac cctgcgcccc
     6361 atgcgctacc cggacttcta cgagcgctac cgggacgcga tcaagaacac ctggcacgtc
     6421 gaggaggtgg acctgcactc ggacgtcgcc gatctggcga agctgacgcc cgaggagcag
     6481 catctgatcg gccggctcgt ggcgttcttc gccaccggcg actcgatcgt ggcgaacaac
     6541 ctggtgctga cgctgtacaa gcacatcaac tcgcccgagg cgcggctgta cctgtcgcgg
     6601 cagctgttcg aggaggccgt gcacgtccag ttctacctga ccctgctgga cacctatctc
     6661 cccgatccgg acgaccgggc ggcggccttc gcggccgtgg agaacatccc gtccatccgg
     6721 gagaaggcgg agttctgctt ccggtggatg gactcggtgg aggagatcga ccggctggag
     6781 tcgaaggccg accggcgccg cttcctgctg aacctgatct gcttcgcggc ctgcatcgag
     6841 ggcctgttct tctacggtgc gttcgcctac gtctactggt tccgcagccg gggcctgctg
     6901 cacggcctgg cgaccggcac caactgggtg ttccgcgacg agacgatgca catgagcttc
     6961 gccttcgacg tggtggacac cgtgcgcaag gaggagccgg agctgttcga cgaggagctc
     7021 ggacggcagg tcaccgacat gctgcgcgag gccgtcgagg cggaactgca gttcgcccgt
     7081 gacctgtgcg gggacgggct gcccggcatg aacaccgcgt cgatgcggca gtacctggag
     7141 tgcgtcgccg accagcgtct ggtgcggctg ggtttcgcgc cggtgtacgg ctcggagaac
     7201 ccgttctcct tcatggagct gcagggcgtg caggagctga ccaacttctt cgagcgccgt
     7261 ccgtccgcgt accaggtcgc cgtggagggc acggtcgacc tggacgagga cttctagggc
     7321 ccgggccggg gccgtctcac gccgcccgtg cgtggtggtg cgaggcggcc cggtgctccg
     7381 ggcgggacgc ggcccgcgta tcgggcggtt cggtgacggg cgccgcctcg gcccgccgga
     7441 tctgccggtc gatgcggcgg tcgcgcagga tgccgatcac ggcgggcgcc accatgagga
     7501 cgaacaggcc gagaacggcc accatcgcga tcagtgcttc tgtctgcgtc gtgttcatgg
     7561 acaccactgt ggcgccggac actcctgacc gggagtggca ggactgccgt acaccctcga
     7621 tttactgcca acggcgaggc acactggagt catgctccgg aatgtggcgg ccgtcctgct
     7681 cgacggcgtg aatccgttcg aactcggcgt ggtgtgcgaa gtcttcggca tcgaccgcag
     7741 cgacgacggg ctgccggtgt acgacttcgc cgtcgcctcg gcggaggggc cggcggtgcg
     7801 taccagcacc ggcttcacgc tccagaccga gtacggcccg gagcggctgg agacggccga
     7861 cctgatcacc gtgcccgccg gcgcctccta cgccgcccgg gagttcccgc ccgagatgct
     7921 ggacgcgctg cgccgggccg tggaccgggg cgcgcgggtg ctgagcgtct gctcgggggt
     7981 gttcgtgctg gccgccgccg ggctgctgga ggggcggcgg gccgcggtgc actggaagca
     8041 cgcggaggag ctgagccgcc gctatccgca cctgacggtc gagcccgacg tgctctacgt
     8101 cgacgaggac ccggtgatca cctcggcggg caccgccgcg ggcatcgacg cctgtctgca
     8161 cctggtgcgc aaggaacagg gcccggaggt ggccaaccgg atcgcccgcc ggatggtggt
     8221 ccccccgcac cgcgacggcg ggcaggccca gtacatcgag cgtccgctgc cggagcccgg
     8281 gggcgactcg gtcgccgggg tgctggtgtg gatggagcag cacctcgacg aggaggtcac
     8341 cgtcgagcag ctcgccgccc gcgccctcat gtcgccgcgc accttcgccc gccgcttcca
     8401 gcaggagacc ggcaccacgc cctaccgctg gatcctgcgc cagcgggtgc tgctggccca
     8461 gcacctgctg gagcggacgg acgagacggt ggacgcgatc gcgggccgca ccggcttcgg
     8521 caacgcggcc gcgctgcgcc accacttcgt gcgcgcggtc gggaccaccc cgcagtccta
     8581 ccggcgcgcg ttccggggcc cggaggccgc ctgaccgcgc gccggacggc gggacgtcag
     8641 cggggccgcg cccgcagcat cagccggcgg ggccgcagcg tgatgccgat gcggggccgg
     8701 gggtcggagt ccggcgcctg ctcgaagcgg taggcgtggg cgaccacggc ggtgatgagc
     8761 gtgagctccg ccatggagaa gtggtcgctg ggacacttgc ggttgcccac gctgaacggg
     8821 ctcatcgcgt acttgggcac gtccttggac cgctccggga gccagcggtc cgggtcgaag
     8881 tcttcgttcc gctcgtacga ccgccggtcg cgctggatcg cgtacgggct gtagatgagg
     8941 tccgcgccct tcggaatgcg gtaaccgccg agttccgtgt cggcgaccgc gcggcgggtc
     9001 aatatccata cggccggata cagccgcagg gtctccgtga cgacattcgc ggtgtacgtc
     9061 agccggcgca cgtcgtcgaa tgcgacccga cggtcgccga ccacggattt cacctcgtcg
     9121 cggatcttgt caccgagttc cgggtgctcg gtgagaacca ggaggagtga catcaccgtg
     9181 gacccgacgg tttcggcacc gggggtcagg atggcgatga cctgatcatg gatctcctgt
     9241 tccccgatgg ggtcgccatt gtcgtccttc gcctccagca aagccgtcag caaatcgtcc
     9301 ggtttttgac cgctcgcccg tcggtcggcg acgatctcgt cgaccaggac atgcaaatcg
     9361 gccagtgcgc ggttgaattc ccgattggcc ggaagcggaa ccttgtagag cggcccgagc
     9421 ggcaccacca tgcgctggta catccccgcg aacagggtgg tgaggtcggc gcatatgcga
     9481 tcggcgtggg cgtccatgta gccgccgcgc atcaggcagc gggcggcgac ccgcacggcc
     9541 acgcggaacg actcgtaggt gatgtccagc accccgcccg cgtcccgcca gcgctccacg
     9601 agcgcgtagg cctcctccgc catgatcggg ccgtaggcgg ggatcgcgtc gagccggaac
     9661 gccggctgga tggtgcgccg ctggcggcgg tgcagcgtgc cgttggcggt ggccacgccc
     9721 tccttgccga gcaggctctc cagcgactcc cacaggggcc cggcgatgat gtagtccggg
     9781 ctgagcgcca ccgctccggt gagggcgggg gtggtgacgg cgtagacggt cttgggaccc
     9841 agtttcaggc gcaccacgtc gccgtggtcg cgcagccggg acaggaaggc cagcgggtcg
     9901 cgcaccaggc gccagccgtg gccgaggagc gggacggcgc cgcccgccac aggcggctcg
     9961 gccgtcgtgg tggcgtcctc cgggcgtacg gactcgacgg tcatttctca ccttccgttg
    10021 cgttgtcgac gtacgggggc gtggaccggt cgtcccagct gtcgacccgg taccggccgg
    10081 actcgtggtg gaaccagtag acggaactga accagttccg catgttgccg acgcaggcgc
    10141 gcacggcggc gctcgtctcc tttccgccca ccgtcccgtc gtcgagccgg tcggcgaacc
    10201 gtaatgcctc ctgttccgcg tccaggaatt cgctgatgca ttcctcgacg cggcgccgca
    10261 cgtcggcgat cgcctcttcg agggtcattc cctcgtgggt gacgagactg atgccgagat
    10321 tgtgcacctc gtttccggcg atttccttgg gcagcgaaca gaggtcgttg taccaggcgg
    10381 cgaattcctg actgagcagc gccggtttcc gataggccgg gttcttccgc accgcgtccg
    10441 ggagttcgta ccccgcgctc ggttccagaa ggtccgtcca gatccggtgc gcgaacgtga
    10501 ggcggcgcag ttcgaggtat tcctcgacgg tcgggacgat gccttcggtg cggttgtgga
    10561 actcccggtc gtacgcctcg atcacggcgt ggaagtggcg cgagaaccgc gcgttccagg
    10621 tgtccggaag gaatgcgtgg agccgccgca cgctgtcggc gaggcccgcg accacggggt
    10681 ccgtgtggcc caggtggtca ccggggcggt cgagggcgct gtgcagcagg tccttcagca
    10741 gtcgccaggc ctcgggccgg ccgtgcacga tgtcacgatc gtgacggtcg tcccagacga
    10801 agaaccaggc gctgtagtcc gctatcgcct ggaggacgtc gtcgggcgcg ccgatgtagt
    10861 agcccgccat gaggtccgtg tagcacaggc cgtcggcata ttcctccacc ttctccggcg
    10921 tcatgagccg cttttcgagc agccatgccc gggtctccct ctggagcttc ggccaatacg
    10981 ggtggagttg ccggggaaac gccgcctcga tcaccggaag agacagcgcc ggtggaactg
    11041 cgatggtggt cggtgtcgac gtggagccgt gtgacaaagc atgcacgaac attcccctct
    11101 cagccgccag ttgagcgccc gccccccgag ccgggcgtac gccgtgcgta tccccgtacc
    11161 tccattcagc accacaactg accgttctgg gaacggattt gcttctttca ctccttttgg
    11221 atgcgcacag acgaacggcg cccgtccggg atgtgccgga tcgggcgccg tgcgcgtgat
    11281 gtgaagggag ccgtgagggc ggtcagtcgt tggcgaccac ggggtagcgc ggctcgttct
    11341 cggccatctg cttgagcgcg gccttacgct cgcgcttcga cagacggtcg atgtacaggt
    11401 agccgtacag gtggtccgtc tcgtgctgga ggcagcgcgc gaagtagccc gttccgcgta
    11461 cccggatcgg gttgcccttc tcgtcctgac cggtcacctc ggcgtagtcg ggccggggca
    11521 gcggcgcgta cgcggtgggc accgacaggc agccctcgct gctgtcgtcc agccggcgct
    11581 tctcggcggg cagttcgacc agcttggggt tgcagaccac accgacgtgg cgcaggcctt
    11641 cgtcgtcggg gcagtcgtag acgaagacct tcaggtcgac accgatctgg ttggcggcca
    11701 gacccacgcc ctcggcggtg cgctggctgg cgaacatgtc ggcgacgagc tgctggaact
    11761 cctcgccgaa gtccgtgacg tccttgcact ccttgtgcag caccgggttg ccgaccacgg
    11821 tgatcgggcg cgaggtgccg cgctcccgcc acttggcctc gcgcttctcg cagtcctccg
    11881 tgtcgatgac gtagccctcg tcgtcgacgg ggagcacgcc cgcgtgctgc tgatcggtgt
    11941 cctgctgagc catgaccgac gtgtgccttc ctgagatgac cgagaatgct gtgacaaggg
    12001 taagtgcagc gcccctcgaa ggggcgcggg gaactgcgcg ctcagccccc acggcccccg
    12061 cacccggcga cggtgctagc aaacctcttc gagatcccgc caatccctgg aatcaggact
    12121 gtcagcgacc cacccgtcca acaacccccg caccaaagcc gcaggcgcgg caatcccgca
    12181 ctccctctcc ggcacccaca actgcccgtc cgtccgatgc cccaacggcc cggggtgccc
    12241 cggctcactg tgatcgtgag gatcgagatg ctccccgtcc ccctcgtcgg acggcatccg
    12301 tgactccgag cacatccggc acaggagccg caccgacgac gaccagtcct cggccgcgaa
    12361 cccggcgtcg gaggcgagct gttccagcgc gtcccggtcg gcctcggacg cggcctccag
    12421 cagcaccacc caggtcggca ccggcgaggg cgcccacaac tcgatctcgt cgaacaccgg
    12481 gtaggtgtgc ccggctgcgg tgctccgctc gccgtgcggc accccgtcgt gcaggacgac
    12541 ctcgccccag cggcgtccgg aggacggcag cgggatggac agcacctcga tgcgggcggg
    12601 gtcgagccgc cgcccccaca ccacttcggc ctccccctcc ggtgacagcc gtacggccgc
    12661 gctgcccagg tccatgccga gaggctcgcc cgagtcggtc gctggtcccg gcaccttgag
    12721 cccgtacgcc tgccaggcac ggcgggccag cggccagtcc tggagggcgg tggcggcgat
    12781 gcccacgttc caccagtcgg gcgccccggt gtcgcggtcg agcagggcga cggcacgcag
    12841 cccggccgcg cgcgcctgct cccagtcgtg ccggaacttg tgcagcagcg cgaggttgaa
    12901 ccaggactcc gacagccagg gctccagatc ggcggcccgc gtcagcagcg cgcccgcgtc
    12961 ctcgtaccgg ccgtcgccga tgagcgtgaa cgcgcggtcc gtggcctgcc gccaggaggc
    13021 ggagggccgg tgacgtccct tgccgaagat cctcacgatt cccgcctgcc agttccgttc
    13081 ggtgggccgg ccgcagcggt cggcaccccc ggccaccctc tccttcgcat ccaaccacgt
    13141 acggccgcga gggcgctcat tacccatggg ttacccagct ctgccgggaa ccagaccgcc
    13201 cggtccgccc tctcaccacg accggtccat ctgctcacgc gtcccctccg tgtcccggga
    13261 cagaaccctg gccagggcct cgacgacctc cggcgcgtac tccccggcgg ccttgagccg
    13321 cagttcctcc agcgcggtca gcggcccccc gggccctcct tccctgcact tctcgtcgta
    13381 cgcgttcacc acccggacga tacgggcggc gagcggctgc tcggcgtgcg ggtcggcctg
    13441 acgttcgacg atcccggcga cccgggggtc caccccggtc tgccgcacca ccgcgccgcc
    13501 caggagcgcg atgcgccgct gctcggcggg cggcagtccg gcggtggcgc cctcgggcac
    13561 cgggtccacg aggctgagct gcccgatgtc gtgcatcagt gccgcgtact ccagcacggt
    13621 cagctccggc tcggtcagcc cgaggtcccg gcccaccgcc tggctgagcg cggcgacccg
    13681 gcgcgagtgc ccgtgcgggg tgcacccggc gatctcggtg gcgcgcgcga gggacgcgat
    13741 ggtctgccgg taggtggcgc gcaccgccgt gtacctccgg tgggacagct gcgcgagcag
    13801 cagcggcacg gagaacacgg gcagcgccca cagccccacg accgccgcgc ccagcgccat
    13861 caccgcgccg gtcgcgacga cggcggcccc gatgccgggc acggaccgca gttcgtcacg
    13921 cagcagcggc gggaagggcc agccggtgcg ggagtgggcc agcgcggcgg cgagcaccgc
    13981 gtcgcacagc gcggtcaggg tcagcaggac gagcagcagc agcgcgtgcc ccggcccgct
    14041 gaagtcgtcg aacgcgcccc gggcgtgcag cgggtggaag cacacggcga cgaagccgac
    14101 ggtcagcacc ctgcgggtca ccgggtccag ggcgggcccg tcgccgcgtc cgacgtgcgg
    14161 gacgctgccg agcagcgacg cggcgagcac cacggtgacg acctgggcgg cgccgtgccc
    14221 ggcgggccgc cccgcgacct cgccgagcag cgcgtacgcc agcgatcctg ccgtggccac
    14281 cggcgcgggc tcccggatcc cccggccgcc ccgccgggtg agctcgccga ccgcgacgag
    14341 cgtgccgaag gcgagggcga cggagcggtc ctcgacgccg tggtagagcg tcgtgcccag
    14401 cgacccggcc gcgaggaccg cggcgcacag atgcacgacg gtgtgcagcg ggacggtgtg
    14461 cgcgcggggc ctcaccggcg cgccccggga cggccggtga cgtgtccggc aggaccgggc
    14521 acggccgtcc gccgcggctc gtcggcggtc accgcggggt gccagccggt acggccgatc
    14581 gcggtgacga gcgccttcac catccgcggg tcgaagtgcg tgcccgcgca ccgctccagc
    14641 tcctccagcg ccaccggcac cgggcgcgcc ctgctgtagc tgcgggtgga ggtcatcgcg
    14701 tcgaaggcgt cggcgaccgc gaccacccgc gcggactccg ggatctgacc tcccgccagc
    14761 ccgtaggggt agccggtgcc gtcgaggcgc tcgtggtggt gcagcacggc ggcgcgggcc
    14821 tcgccgagga aggagatgcc acgcaccatt tcgtgcccgt actcggggtg cagttcgatg
    14881 acccgccgct cctcgggggt gagcgggccg ttcttggtga gcagccgggt gggcacgccc
    14941 agcttgccga cgtcgtgcag gatgcccgcg aagcgcagcg tctcgacccg ctcgtcgtcc
    15001 atgccgagtt cgcgcgcgat cagcatggag gcgcggccga cgcgctcgct gtggccgcgc
    15061 gtgtagccgt ccttgatgtc gacggcctgc accagcgcgc ggatcgtggc ctggtgggcg
    15121 gcgcgctccc ggtggtactg ggcgaacgcc caccacgaga cgcccatcgg cagcagcacc
    15181 agcagtgccg cgaccggccc gtaggggctg cgccacagca gggccatcat cagtccggcc
    15241 aggccgtgca cggtgagcgg cgccagggag ccgaggaaca gccgccacca ggctgccacc
    15301 ggacggccgc gccgcagacc accgggggcg ggcaccagga cgccgccgtc gagcagggtg
    15361 aggacgaggc agaacgccag cacggcggcg cccgccgtgg cgagggcgcc cggcatgtcg
    15421 cagtgcgcca ccgcgtcgcg gccgccggtc ttcagatgga ccaggccggc ggcccacacg
    15481 gcgacgacga gccggcccgt gcgccacagc cggcgtgcga gacgcgggcc gtgctcgacg
    15541 gggagcagca gtgccccggg cagcgcgacg agggcggcgg cggtgggcgg cagcaggaag
    15601 gccccggcga gcagcacggg gtggaaggtc ccgccggggt gtggtcccgc gacgagtcgg
    15661 gaccgggcga gacgctcgca gcccgcgtac agggcggcga gcaggacgac cggccaccag
    15721 gggacgcgcg ggtcgggcag ggacgacagc accccgggcc gggggacgcc cgtcagaggg
    15781 agcagacagc acagtcccag cagggtgacg ccgacgagat agacccgggc ccgcgccggt
    15841 aacgcctcca tgagcccctc ccccgaccgt gccgcgcgcg ccttccgtcg cccgccggct
    15901 tctggagcct aggacggggg agggcgccgc cgcgggcgga ccgcccgcgg attagcacaa
    15961 tcgggtgacg cggcccagag ggtggggagg tgtcaggact cctgcggagc ggtcgtcacg
    16021 tcctgctcgg gcacgttctg gccggagcgg atcaggtcga tccggcccat gaccttcgag
    16081 cggaggtcgc cgggcacgtc gtcctgcccg caacaccgct tcacgagctt cttgaccgct
    16141 tgctccaggc cgtacttctc caggcagggc gagcactcct cgaagtggtg ctcgaacttc
    16201 cggcagtcgg catccggcat ctcacggtcg aggaactcgt agagatgatc gaggatttcg
    16261 ctgcaatccg tctcgtgcgg ctctccgcag ctcatgaccc cgagcctttc gcttcgttcg
    16321 actctccggc accggccggg accagtccgc gctcgcgcgc gtagtcctcg agcatgccgc
    16381 gcagctggcg acgtccccgg tgaaggcggg acatcaccgt tccgatgggt gtccccatga
    16441 tgtcggcgat ctccttgtag gcaaagccct cgacatcggc gagatagacc gcgatgcgga
    16501 actcctccgg gatcgcctgc agggcttcct tcacgtccga gtccggcagg tggtccagcg
    16561 cctgcgactc ggcggagcgc agacccgtgg acatgtgtga ctcggcgcgc gcgagctgcc
    16621 agtcctcgat ctcctcggcc gcggagcgct ggggttcgcg ctgcttcttg cggtacgagt
    16681 tgatgaaggt gttggtgagg atccggtaca gccacgcctt gaggttggtg ccctcgcgga
    16741 actggtggaa ggacccgtac gccttggcgt aggtctcctg caccaggtcc tcggcgtcgg
    16801 ccgggttgcg cgtcatgcgc agcgcggccg agtacatctg gtcgaggaac tcgagcgcgt
    16861 ctcgttcgaa gcgcgcgctg cgctccgctg tcgactccgc gcgcgtgtcg ccctggccct
    16921 cgggctgctc cgcctggccg tgttcggtcc ctgcgtcggt accgggaacc ggacccacct
    16981 cctcaagtgt cgtcgtgaga ccgagaccgg cctcacccga atcggaggat agacgacgat
    17041 ccggtccgcc cgccgcccga atcggggcgg tcttggccgc gtgcagcacc gtccagtcga
    17101 ggtcggcgcg ggcactgcgg ctcgggcaga acgtggaacc catgcggtgg acttcctctc
    17161 ctacggcggc ggtgccgttc gaccggcacg tacgcacccc acaacagcgg gggcggtccg
    17221 cgcattcccg gcgcccgtca gcggaggccc gccgtccacc gcacgaccgc gtccgtgatg
    17281 acgtggagcg cctcctcctg tgtgaggtcc gcccgcctgg gcacggcgaa gccgtgatcg
    17341 gcccgctcca cctccaccag ctcgtgatca ccctcgggga actcggcggg tttcccgaag
    17401 gggtcgttgc cgccctggac gacgagcgtg gggacgcccg cgccgagcag ttccccggcg
    17461 cgggacttct ccggcttgcc cggcgggtgc agcgggaagc tcagcgcgag cacggcgtgc
    17521 gcgcccagtt cgacggcggt gcggcaggcg acgcgggcgc cggcgctgcg tccgccggag
    17581 accaccggca gaccgggcct cgtcagcgcg ggccagacgc cgcgccagcc ggtgtccagg
    17641 gtcttcggcg ccggggcgac cttcttcccg gccacccgcc agggctgctc gacgagggcg
    17701 acggtcacgc cgtgcgcggg gaggacggcg gcgagcgcgg cgaggtcgcg ggcctcgatg
    17761 ccgccgcccg cgccgtgact cacggcgagg acaaggcgcg gccgcccggc gtggtgccag
    17821 gtgatgcggg cgtcgccggc gtccgtggtg atcgtctcgg tggtgacgtc ggactcggat
    17881 gtcgcttcgg actcaggtgt cacttcggac tcaggtgtca cgtcagactc gggtgtcacg
    17941 tcagactcga atgtcacgtc agaagagtgt gccctcttcc ggggcggcca gctccttcaa
    18001 cagctccgga ccgttgttgc ggacgttgct gacggcggtg gtgaccgggt aggcgcgcat
    18061 caggccgggc tccggcgggg cgagcagccc gcgcaggtcc tcggggtcgg tgcgggaggg
    18121 gtcgagccag gcgtcccagc ggtccggggt gagcatcagc ggcatccgcg ggtggatctc
    18181 ggccagcgtg tgcgggccgt ccgccggggc cacggccagc gggctcgtct ccgcctccgt
    18241 ggtgatcacg gagcaggtca cccaccaggc ccgcgggtgg tcgtcgggca gggtgcggtc
    18301 gcgccagaac tcgtacagtc cggccatcgc gaagaccgag ccgtcggccg gggtgacgaa
    18361 gtagggctgc ttgcggggcc gcgtcttctt gccctcgacc tccaggtcgc gctcctgctt
    18421 gccggtgacc cactcgtagt agccgtcggc ggggaggatg cagcggcggg aggcgaaggc
    18481 acggcggtac gacggcttct cgtggacggt ctccgcgcgc gcgttgatca tccgggcgcc
    18541 gccctcgggg gtcttggacc aggagggcac cagtccccac ttcagcgtgc gcagctgccg
    18601 aaccgggcgg gggtcgtccg cgtccttcag aggacggtcg aggacggcgt agacctcctt
    18661 ggtcggcgcc acgttgtagt cggcctccag ggtctcctcg ggctcccact tctcgacctc
    18721 gaagatcccg gcgagatcct cgggcctccg actcgctgca taccgtccgc acatacgtgc
    18781 aacactgcca gactccgcac gcgcacaggg agcgatccaa cacacatgac gagcatggtc
    18841 agcaccgcgt ccgcgtccct cgcctccctc tgggacgagg tcgcgggcac ccagcccgac
    18901 ccggacctgt gggtggtcgt cgcgaccctg gtggcggccc tcgccgtggt ggtgccgcag
    18961 gcgccctggc gagtcgcacg gaacgcgatc accatcgcgc acgagggcgg gcacggcctg
    19021 gtggcactgc tcaccggccg caccctgacc ggcatacgcc tccactccga caccagcggc
    19081 ctgaccctca gccgcggcaa gccgaccggc atcggcatga tcctcacggc cgccgccggc
    19141 tacaccgctc ccccgctgct gggcctcggc ggggcggcgc tgctcggcgc ggggcgcatc
    19201 acgctgctgc tgtggctggc caccgcgctg ctgctggcgg tgctggtgat gatccgcaac
    19261 gcctacggtg cggtgtcggt gctggtcacc gggggcacgt tcgtgctggt gtcgtggctc
    19321 gcgggaccgc aggtgcaggc ggcgttcgcg tacgccgtgg tgtggttcct gctgctgggc
    19381 ggggtgcgtc cggcgttcga gctccaggcc aagcggcggc acgggggcgc cggggactcg
    19441 gacgcggacc agctgtcccg gctgacgcac gtgccggcgg ggctgtggct gttcctcttc
    19501 cacgcggtgt cggtgtgctc gttgctgggc gggggacgct ggctgctggg tctgtgaccg
    19561 ggcggcccgg cgggtgagcg ggcggtgttc cgcctggcgg gcacggaacg gccgggctcc
    19621 tcacctcctt ataaagtggc cccatggccc cgaaccccac gcacaccgcc ctctggcccg
    19681 ccccgcacgc gagcggagcc gtcgacgcga cggtccacgt gcccgggtcc aagtcggtca
    19741 ccaaccgcgc tctcgtcctc gccgccctcg cctccgagcc gggctggctg cgccgcccct
    19801 tgcggtcgcg cgacacgctg ctgatggcgg gcgggctgcg cgcgatgggc gtggagatcg
    19861 aggagggcgt cggtcccgac gggacgggtg aggcctggcg tgtggtgccg gccggtctgc
    19921 gcggcccggc cacggtggac gtgggcaacg cgggcacggt gatgcgcttc ctgcctccgg
    19981 tggccaccct ggcggagggc ccggtgcgct tcgacggcga cccgcggtcc tacgagcgtc
    20041 ccctgaacgg tgtcatcgac gcgctgcgca ggctgggcgc ccgcatcgac gacgacgacc
    20101 ggggcgcgct gccgatgacg gtgcacggcg ggggcgcgct ggacggtggc acggtcgagg
    20161 tggacgcctc ctcgtcgtcg cagttcgtca gcgccctgct gctgtcggcg ccgcgcttca
    20221 accagggcgt ggaggtgcgg cacaccggcg cgacgctgcc gtcgatgccg cacatccgga
    20281 tgacggtcga catgctccgc gcggtcggcg cccaggtcga cacccccgag tcgggcggcg
    20341 agccgaacgt ctggcgggtc accccgggcg ccctgctcgg ccgggacctg acgatcgagc
    20401 cggacctgtc caacgcgcag ccgttcctcg cggccgcgct gatcaccggc ggcagggtgg
    20461 tgatccccga ctggcccgcg cgcaccaccc agcccggcga ccggctgcgg gagatcttca
    20521 ccgagatggg cggctcctgc gagctgaccg agtacgggct ggtcttcacc ggctccggtg
    20581 cggtgcacgg catcgacgtg gacctcggcg aggtgggcga gctgacgccg ggcatcgcgg
    20641 cggtcgcggc cctcgcggac tccccgtcga ccctgcgggg cgtggcccat ctgcggctgc
    20701 acgagacgga ccggctggca gcgctcacca aggagatcaa cgagctgggc ggcgacgtca
    20761 ccgagacggc cgacggcctg cacatccgcc cgcgccggct gcacggcggg gtcttccaca
    20821 cctacgagga ccaccgcatg gccaccgccg gtgcgatcat cggcctggcg gtcgacggtg
    20881 tgcagatcga gaacgtggcg accacggcga agaccctgcc ggacttcccc gagctgtgga
    20941 ccgggatgct cggggcatag gggttcacga tgcgccgcta cggcaagcac accgacgagg
    21001 acgacatccg ctcccgcccc aaccgcaagg gcaaccggcc gcgcacccac atcaggccca
    21061 agcacgagga cgccgccgag ggcatg
//
