LOCUS       NZ_BMTZ01000001        22157 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces variabilis strain JCM 4422 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BMTZ01000001
VERSION     NZ_BMTZ01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces variabilis
  ORGANISM  Streptomyces variabilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces griseoincarnatus
            group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 699561)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 156X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649935.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:37:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,743
            CDSs (total)                      :: 6,668
            Genes (coding)                    :: 6,496
            CDSs (with protein)               :: 6,496
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 172
            CDSs (without protein)            :: 172
            Pseudo Genes (ambiguous residues) :: 0 of 172
            Pseudo Genes (frameshifted)       :: 61 of 172
            Pseudo Genes (incomplete)         :: 147 of 172
            Pseudo Genes (internal stop)      :: 11 of 172
            Pseudo Genes (multiple problems)  :: 42 of 172
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:23:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 200290
            Orig. end                         :: 222447
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMTZ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22157
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22157
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22157
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12157](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12157
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            690..1355
                     /locus_tag="IE148_RS00825"
                     /old_locus_tag="GCM10010287_01670"
     CDS             690..1355
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445352.1"
                     /locus_tag="IE148_RS00825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01670"
                     /product="ABC transporter permease"
                     /protein_id="WP_086702543.1"
                     /transl_table=11
                     /translation="MNVLNFVQAFFSDSAHWHGYDGIPSRFLEHVRYTLLALAVAAAIG
                     LPVGLLTGHTGRGGNAIAVVANAARALPSFGLLVLSVLLIGFGLLPVMIPLVVLAVPPI
                     LVTTYEAVRTVDPAPVDAARGMGMPESGVLFRVEVPVALPLILSGLRSAAVQIVSTATI
                     AAYVSLGGLGRYVIDGLYQRNYEKVVGGATLVAVLALITLALFRAVERFAVSPGVRRR"
     misc_feature    complement(1365..1379)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.84"
                     /tool="antismash"
     misc_feature    1367..1384
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.04"
                     /tool="antismash"
     gene            1431..2387
                     /locus_tag="IE148_RS00830"
                     /old_locus_tag="GCM10010287_01680"
     CDS             1431..2387
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972856.1"
                     /locus_tag="IE148_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01680"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_086702542.1"
                     /transl_table=11
                     /translation="MTSTAKSSRSRTRHHGAAAVALAAAAALLTGCSSGDTSDNPLDGD
                     KAEAGTVVVGSNNFAESTLLADIYGEALRAKGLKVSYKHNIGSRETTYGLMKNGSVTVL
                     PEYNGSLLAYLDEKAEQTSADAVNEAVKAKLDKQLTLLESSPAEDKDSVALNAATAKKY
                     GLTAESTLADLKEAAPELVIGGSPEFQTRQQGLKGLEAVYGLTFKSFKALDAGGPLTQA
                     ALAQNEVQAADVFTTDPTILKEKFVVLKDPENLFGYANVTPLVRKDGLPQEGVEALNAV
                     SAKLDTKTLLDLDAQVQLEKKDPLDVAKAWLKSAGLV"
     gene            complement(2434..3033)
                     /locus_tag="IE148_RS00835"
                     /old_locus_tag="GCM10010287_01690"
     CDS             complement(2434..3033)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135577.1"
                     /locus_tag="IE148_RS00835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01690"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_086702540.1"
                     /transl_table=11
                     /translation="MAGSDTVSRASADGGAPDTVKILIAGGFGVGKTTLVGSVSEIRPL
                     RTEEPLTMAGLDVDDLEGVEEKRVTTVAMDFGRITVSGDLVLYLFGTPGQQRFWFMWND
                     LAHGALGAVVLVDVRRPKSSFAAIDFFERRGIPFVVAVNGFHGEHPYPVEDIREALTLP
                     ADVPVLLCDARERESSRDVLIALIDLLIAQAAAAAG"
     gene            complement(3020..3373)
                     /locus_tag="IE148_RS00840"
                     /old_locus_tag="GCM10010287_01700"
     CDS             complement(3020..3373)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993788.1"
                     /locus_tag="IE148_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01700"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_048455547.1"
                     /transl_table=11
                     /translation="MGGSDPSGRLVRPFTLTGGRTRPSRADFTLITTVTTADPQPETAA
                     RPQPEHTRILRLCVRPMAVAELAARLDLPVSVVVIMLCDLLEAGRITVRPPRPVTTPDP
                     DLLQKVREGLGRL"
     gene            complement(3375..3806)
                     /locus_tag="IE148_RS00845"
                     /old_locus_tag="GCM10010287_01710"
     CDS             complement(3375..3806)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523409.1"
                     /locus_tag="IE148_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01710"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_048455546.1"
                     /transl_table=11
                     /translation="MTRPLPATHTQLDQLLTGLVERVADVNQAVVLSEDGLVVSKSTGF
                     LRDDAERLAATASGLMSLSKGVSMDFRGGPVRQALIEMAHSYLILTSAGPGAHLVVLTG
                     PKADVGVVAYQMNMLVKKIGEHLSAAPRETSGPAEDPGV"
     gene            complement(3858..6572)
                     /locus_tag="IE148_RS00850"
                     /old_locus_tag="GCM10010287_01720"
     CDS             complement(3858..6572)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125286.1"
                     /locus_tag="IE148_RS00850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01720"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_246538835.1"
                     /transl_table=11
                     /translation="MSRRTGARRRLGSIRLSLILLALVPCVTLAALWALTTIRMFSEGL
                     ELRSQTQLSRSTGAMGTYAALDLQRERALTADWLAGPDGSRSALVTQRRATDRSVARLM
                     GQADAIAQAPARISDRLYSVLGSVGSLEYYRDQIDDPRDITAEEALEQYTSVIDDQIHA
                     FQELSQVDDGDLTSQAQPLVSLEHAAELMSREDALLTLAWPSGRLEAERRQEFAELVHT
                     RRWLVADQIKPALGGDLKTQTERILSSPEWRALEAVEDQVLATPAEGEAQEVELPDLRD
                     RWAEAMDKVTPQYSAMIRQQTDALLTRSADEAGGLLVTAGSLSAAGLLALLLCVVLSWR
                     ITRSLSRRLRGLRLATLGLAQERLPDVVARLERGEKVDPESATTPLDYGHDELGQVAQA
                     FNTAQRTAVHTAVELADTRRGFQKIILGIARQSQNLVNLQLSKLDALERRHTDPEVLKG
                     LYELDSAASQLRRYEENLVIVSGERPGRTWSEPVALIDILRSAVGEVAEYQRVEVYADE
                     EVSLAPPAVADVIHLLAELIDNATVYSPAPSPVTVRAAMVAKGLAVEIEDRGLGMSEED
                     YASLNAHLAEPPQFDVVALADDLRLGMFVISQLAHRHDIAVTLRPSPYGGTTAIVLVPH
                     EVVVVTDEPSDAPREASAAEGASPRDGSSPLRPLPTRDRAGAARKAAAEGAAAGANDAG
                     SAPDGSGTAGAGADGAAGRSGVTRGGSGTTGEDAPAGRDDTTDGPGAAGDGSAAGGSDM
                     GPAAAGPAAARAGSRPTQGIPGSARVGSAPADGDTAMPPTASATPPGGAGTPHKPAAPE
                     PNGSRTARKGGLAPLPRRVPQTSLAAELLEEPSVEDPCDDEFTAEHASSSLACFQQGTL
                     RARGAVDDGPEDGPPRVPAPASGHPTPTADADR"
     gene            complement(6621..7625)
                     /locus_tag="IE148_RS00855"
                     /old_locus_tag="GCM10010287_01730"
     CDS             complement(6621..7625)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972851.1"
                     /locus_tag="IE148_RS00855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01730"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_189363427.1"
                     /transl_table=11
                     /translation="MNTRPPSRRTPRRRTAVLAAATALLMAGCSSSGADEGDDGTGSVS
                     GSGDLRVALVTHGSEGDEFWDRVRKGAEAAAAKDGIELTYLSDPDGAGQADLVRQAVRD
                     GVDGIALTLAKPQAMKGPVNEARAADIPVVGLNSGADAWKKAGLLTFFGQDESLAGRAV
                     GEKLNQLKAEHTLCLVHEQGNVGLEARCAGVKKTFRGTSENLYVDGTDERAVSGILTAK
                     LRQDPSIDQVVTNGADFALLAVDAAAEADSGAEVATFDLNEELVDAVRGGNVRFAVDQQ
                     PYLQGYLAVDALWLYRTNGNVSGGGAAPVLTGPAFVTKAEADSVAGFAAAGTR"
     misc_feature    complement(7972..7992)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.83"
                     /tool="antismash"
     misc_feature    complement(7978..7995)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.16"
                     /tool="antismash"
     gene            8040..8687
                     /locus_tag="IE148_RS00860"
                     /old_locus_tag="GCM10010287_01740"
     CDS             8040..8687
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981896.1"
                     /locus_tag="IE148_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01740"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_048455543.1"
                     /transl_table=11
                     /translation="MARQVRAEKTRATIITAAADLFDRQGYEATSLSDIVEHARVTKGA
                     LYFHFAAKEDLAHAILELQSVTCHRLARDTGARGRTSLEALMRLTFCLARMSAEDPVLR
                     AGLRLATGVTRPRPPLSHPFTEWLDIVSARLAAAVEEADVHPDADIDVVAHSLVCFFVG
                     TRVVGRAREPVTRQPRRTAEMWQLLIRGLVPVTRRARYLSLAARLEREPAPL"
     gene            8728..9906
                     /locus_tag="IE148_RS00865"
                     /old_locus_tag="GCM10010287_01750"
     CDS             8728..9906
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523405.1"
                     /locus_tag="IE148_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01750"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_086702536.1"
                     /transl_table=11
                     /translation="MPDTPAGPVIVADEPGTFPYGVLAERHPAILRQVAADTPYGPEQR
                     RALDALLANCTEGAVTPLPAGAHDRDRWAAWGMDDHAGRSWHDVPWLWSESWFYRQLLQ
                     AVGYFEPGPWQGVDPFRPAKLAELDAPATDEELAALDTLDDLPEDERARALLHGSLWGN
                     RADLGFRMSAEGAEETAAVPALVADDGERLWSLLDGSPDGTLCLVADNAGRELVPDLLL
                     IAHLLAHGRVTRAVLHVKPHPYYVSDATTADVLDAVRRLTAAKGAAGAYGHALRAALTD
                     GRLELRAHPFSCAPLPYADMPDDLRADFAEATLTVLKGDLNYRRLVGDRYWPPTTPFAD
                     VTAYFPGAVAALRTLKSDVITGLAPETEAALDAEESGRWRTSGTHALIQVRT"
     gene            10001..12157
                     /gene="cyc2"
                     /locus_tag="IE148_RS00870"
                     /old_locus_tag="GCM10010287_01760"
     CDS             10001..12157
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523404.1"
                     /locus_tag="IE148_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01760"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_189363428.1"
                     /sec_met_domain="T1TS (E-value: 1.8e-81, bitscore: 269.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYMPHPARLNPHVDQARAHSTAWAREMGMLEGSGVW
                     EQADLDAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLEKYKRTQDRVGGKAH
                     LDRLPLFMPLEPGTPVPEPENPVEAGLADLWARTVPAMSADWRRRFAVATEHLLNESLW
                     ELSNINEGRIANPVEYIEMRRKVGGAPWSAGLVEYATAEVPAAVAGTRPLRVLMETFSD
                     AVHLRNDLFSYQREVEDEGELSNGVLVLETFFGCTTQEAADLVNDVLTSRLHQFEHTAF
                     TEVPAVALENGLTPPETAAVAAYAKGLQDWQSGGHEWHMRSSRYMNENARPGAPWQSVT
                     GPGASAADVGALLARAASERLRPYRHVPYRKVGPSVVPEIRMPFPLSLSPALEGSRRHL
                     LDWSHRMGILGEGVWDEDKLASCDLPLCAAGLDPDATQEQLDLASGWLAFGTYGDDYYP
                     LVHGHRRDLAAARLTTARLSACMPLDGEEVPLPANAMERSLIDLWARTTAGMTPEQRRP
                     LRTAVDTMTESWVWELSNQIQNRVPDPVDYLEMRRATFGSDLTLGLCRAGHGPAVPPEV
                     YRTGPVRSLENAAIDFACLLNDVFSYQKEIEFEGEMHNAVLVVQNFFGIDYATALPVVA
                     DLMNQRMRQFEHVVEHELPVVYDDFQLSEEARAVMRGYVTDLQNWMAGILNWHRSVDRY
                     KDEYLSGRVHGFLPHRSPAPPVLV"
     gene            12170..12646
                     /locus_tag="IE148_RS00875"
                     /old_locus_tag="GCM10010287_01770"
     CDS             12170..12646
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675702.1"
                     /locus_tag="IE148_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01770"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_246538836.1"
                     /transl_table=11
                     /translation="MEPPALRPRPMPGDHAGPRPDPAPAVPEEPPAGRPRGRRAAAGLA
                     LLLTGAALGVLAAAWTAPAPPSGPALSARLGVEVTDAGRPGALVVGVQNPGPGHTAGLR
                     EGDLLLAVGATRVDTAADLAHEVFRIPPGTPVRLTVRHPTGGYQQLTAVPGILT"
     gene            13343..14470
                     /locus_tag="IE148_RS00880"
                     /old_locus_tag="GCM10010287_01790"
     CDS             13343..14470
                     /EC_number="3.4.11.9"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="IE148_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01790"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_189363429.1"
                     /transl_table=11
                     /translation="MTGTAPVPFTADDYKDRMDRAARQAADAGLAGLLVAPGPDLVWLT
                     GYAPPAVTERLTLLVLAAGREPVLVVPTLEAPDAEKATGAPALALRDWTDGKDPYALTA
                     ALLGDRGRFGVSDNAWALHLLGLQQALPGTSYVSLTDALPMLRAVKDAAELERLAAAGA
                     AADAAFEEIRKVRFSGRPESEVAADLAALLRRFGHSQVDFTIVASGPNGANPHHEAGDR
                     RIERGDMVVLDFGGLKDGYGSDTSRTVHVGEPTEEERRVHDLVREAQEAGFRAVRPGAA
                     CQDVDRAARAVIADAGYGEYFVHRTGHGIGVTTHEPPYMIEGEERPLVPGMCFSVEPGV
                     YLPGRFGVRIEDIVTVTEDGGRRLNDTERGMVIVD"
     gene            14536..15486
                     /locus_tag="IE148_RS00885"
                     /old_locus_tag="GCM10010287_01800"
     CDS             14536..15486
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523401.1"
                     /locus_tag="IE148_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01800"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_189363430.1"
                     /sec_met_domain="APH (E-value: 3.3e-22, bitscore: 74.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTVDTVRRLARSLLKDSGHGTGASAAALDVRLAGDGADP
                     TTWLVGTRYVLHLAPDRATGVRWRRELRLREVVRPHVSVALPVGVAQGEWAPGLPCTLE
                     TRLPGGTAEENTVSAVGETDLAGLLTGLHQVPVRQAEALGVPRVPPRSLETLRRAAGEA
                     VELLDKADEFEAARLRQFTQAATVQLAAQAGSVVLVHHALTGGNLVVGADGRVRGVLGW
                     DTAVVGDPAEDIAGLARAVGAPAAVRAATLAGYGARPCLRGLWLARCDCVIHLAEALVH
                     NATASLPLLRTRLRRAWEPIMLERVTDLRDSDAAP"
     gene            complement(15545..17290)
                     /gene="treZ"
                     /locus_tag="IE148_RS00890"
                     /old_locus_tag="GCM10010287_01810"
     CDS             complement(15545..17290)
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034231.1"
                     /locus_tag="IE148_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01810"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_086700554.1"
                     /sec_met_domain="Alpha-amylase (E-value: 4.6e-12, bitscore:
                     41.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQAGRVTLRCDGVTRALERDPEREGWWRGEAEAHDGSR
                     YGFALDDGPVLPDPRSRRQPDGPDGLSAVVDHDRFEWSAEWTGRPLPGAVLYEMHVGTY
                     TPEGTFDAAAERLGHLADLGVTHVELMPVCPFPGRHGWGYEGVSLWAVHEPYGGPEGLK
                     RFVDRAHGLGLGVVLDVVHNHLGPSGNYLPQFGPYFTDTHHTPWGVAVNLDAPGSDEVR
                     AYLVDSALAWLRDHRIDGLRLDAVHALVDTRARHFLEELSQAVDELAADTGRPLFLIAE
                     SDLNDPRVITPRDRGGLGIHAQWNDDFHHALHTALTGESQGYYADFARAPLAAVAKTLT
                     GGFFHDGTYSSFRGRHHGRPLDRTRVAAHRLLGYSQTHDQVGNRAQGDRLSALVSPGLL
                     ACAAALTLTAPFTPMLFMGEEWAAGTPWQFFTDHTDPELAKAVSQGRRREFAAHGWAEQ
                     DVPDPQDPATRDRSCLDWSEPEREPHARMLAWYGQLLAVRREQPDLTDPDLADTKVAYD
                     EDRRWLAFRRGDVRVAVNLGAEPADIPLGSREARVLAAWEPVDVPGADGLLRLPGESAV
                     VLLQE"
     gene            17511..18062
                     /locus_tag="IE148_RS00895"
                     /old_locus_tag="GCM10010287_01820"
     CDS             17511..18062
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385491.1"
                     /locus_tag="IE148_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01820"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_086700555.1"
                     /transl_table=11
                     /translation="MTSSFEFSTYPARLSDAERDKALSVLRDGVAKGRLSHDTFIRRME
                     LALVARRADELTALTADLPRENRFSRVVFGSVEAVSGFTVRLRRAWRAEKLPKLLLPHP
                     AHGHPLRIGRDPASGLRLTHETVSRVHAELTRQGGLWVLRDLGSTNGTTVNGRRVVGAA
                     VVREGDQVGFGRIVYRLSVN"
     gene            18197..19582
                     /locus_tag="IE148_RS00900"
                     /old_locus_tag="GCM10010287_01830"
     CDS             18197..19582
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523398.1"
                     /locus_tag="IE148_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01830"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_189363431.1"
                     /transl_table=11
                     /translation="MDDGVASWRCDLTPLLSYPTVDELGARAASLAARHPRDARLRRVG
                     VSRAGTPLWLLGVGHGSRQALVVAGPHANEPVGGATVLRLAEHALADRRFTDGADVTWN
                     LLLCLDPDGLRHNERWLTGPYTLGRHFRHFYRPGFLEQPEWLPDGAASAALPETRALLA
                     LQDELRPFLQCSLHGVDVGGGFVELTHELPGLDRRVAAVAARLGVPRELGAYDALYWPG
                     LGPAVYLIPPPRRRDLAAAITEAAVESTWYHPYGYGTVTAVVEAPMWGVAAVGNGAPHP
                     DPDAELRSVSRTLRRDTGLLGELAARIRPYVAGVPDADRLLAPVEDYLLVCPGLADAWD
                     PDCGNDSARPLPPMTTAHLAALRLAGRRLALRTAGLLHQLVTRAGRDPADALPELNRLM
                     DARCADLRDTLGARWIPVDRQAEYQARVIRAVCALAVRRTPGASRSGEPGWGPGPAVPM
                     HRE"
     gene            19579..20004
                     /locus_tag="IE148_RS00905"
                     /old_locus_tag="GCM10010287_01840"
     CDS             19579..20004
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007502264.1"
                     /locus_tag="IE148_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01840"
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_244789756.1"
                     /transl_table=11
                     /translation="MTHTSVKTVGAGLSAAALLVLAGATPAAHADTSPEPGNWLMLSVS
                     HGEAPAAGAEGGTLLRCDPPGGGHPHAEEACAQLSAADGRITTLPAENTLCPMIHAPVT
                     AHAEGVWRDRPVTWSETFPNTCALRAHTGALFALDGT"
     assembly_gap    20330..20361
                     /estimated_length=32
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     assembly_gap    20599..20634
                     /estimated_length=36
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(20841..22097)
                     /locus_tag="IE148_RS00910"
                     /old_locus_tag="GCM10010287_01850"
     CDS             complement(20841..22097)
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700049.1"
                     /locus_tag="IE148_RS00910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010287_01850"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_086700559.1"
                     /transl_table=11
                     /translation="MGPLRESRYPTVAELVFSARALAIQWPGLCVLRQVGASRGGRPLH
                     LLSVGRARHAVLVVAGAHANEPAGNGTLLALARRTLLERELRDGVSWHFLLCADPDGAS
                     LHVTPAPRSLYDYHLGFFRPAGSEQPEWAPSVLPADRLPPETRALTGVIDELRPFLQVS
                     LHGTDLGGSWVQLTRDVPGLAEPFAKSAAELHIPVETGASDAAGWPASGPGVHVMPAPE
                     AAPAYPSLSDDARHSTWYHAHRYGGLTAVVEVPMWASDLVDDPAPHPAPDTAMHALAER
                     LLRDADAVRHVLEDVRPGPPPTEADGPLLRAAAWVLELVPGLAADLVRTPPADGTRAYV
                     GSVDAFARRVPLRAAAMLRRALRDTDAQAAARLDHLVAHWSDAFATRFRARWVPVRHQV
                     EHQSRTVVAAARQARAGLM"
ORIGIN
        1 ggcttcttcg acatccccag cgacctccag cacagctggg ccggcctgat cggggtgcat
       61 ctgcgcgagg cgctgctgcc ggtggccgca ggcctgctgc tcgccctgcc gctggcgctg
      121 ctgtgcaacc ggttccgctg gctgtacccg cccgtgctcg gtgtgacgac cgtcctctac
      181 gcggtaccgt ccctcgcctt cttcgtcgtg ctgatcgact ggacgggcca gaccgagctg
      241 accgtgatga tcccgctggc cctctacagc ctggtggtgc tggtcccggc gatcgccgac
      301 ggcgtgcgct cggtgccgga cgagaccctc tccgccgcca ccgcgatggg attcggcccc
      361 gtccggcggt atctccaggt gcagttgccg atcgccgcgc ccgcgatcgt cgcgggcctg
      421 cgggtcgcca ccgcgtccag catctccctg gtgagcgtcg gcgccctcat cggcaaccag
      481 ggcgccctcg gcaatctgat ggccgccgcg cagaagtacg accggcccga actcgcggcg
      541 aacgccgtgc tgaccacggc ggtcctggcg gtcctgtgcg acgccgcgct ggtcgccctg
      601 cgccgcgcgc tgaccccgtg gatgccccgc tccggacggg aacggaccgc cgccccgcgc
      661 gaggaactcc tcacgaaggg cgccgcccgg tgaacgtcct caacttcgtc caggcgttct
      721 tcagcgacag cgcgcactgg cacggctacg acggcatccc gtcccgcttc ctggagcacg
      781 tccggtacac cctgctggcc ctcgcggtcg ccgcggcgat cggcctgccc gtcgggctgc
      841 tgaccgggca caccggacgc ggcggcaacg cgatcgccgt cgtcgccaac gccgcccgcg
      901 ccctgcccag tttcggcctg ctggtgctct ccgtgctgct catcggcttc ggcctgctgc
      961 cggtgatgat cccgctggtc gtgctcgccg tgccccccat cctggtgacc acgtacgagg
     1021 cggtccgcac cgtcgacccc gcccccgtcg acgcggcccg cgggatgggt atgcccgagt
     1081 ccggggtcct gttccgggtg gaggtgccgg tggcgctccc gctgatcctc agcggtctgc
     1141 ggtccgccgc cgtccagatc gtgtccacgg ccaccatcgc cgcctacgtc agcctcggcg
     1201 ggctgggccg gtacgtcatc gacggtctct accagcggaa ctacgagaag gtcgtcggcg
     1261 gggcgacgct ggtggcggtg ctcgcgctga tcacgctcgc gctgttccgg gccgtggagc
     1321 ggttcgcggt gtcgcccgga gtgcgacgcc gctgacattc gatcagttgt acgacaaatg
     1381 tgaccctgac gttcttgacc gggcgtgaga cggctggatt ggatcggtga atgacttcca
     1441 cggcgaagag cagcagatcg aggacgaggc accacggagc ggcggcggtc gcgctcgccg
     1501 ccgcggcggc gctgctcacc gggtgttcct ccggggacac ctccgacaac ccgctcgacg
     1561 gtgacaaggc cgaggcgggc acggtcgtcg tcggctcgaa caacttcgcc gagtccaccc
     1621 tgctcgccga catctacggg gaggcgctgc gcgccaaggg cctcaaggtc tcctacaagc
     1681 acaacatcgg cagccgtgag accacctacg gcctgatgaa gaacggctcg gtgacggtcc
     1741 ttccggagta caacggctcc ctcctcgcct acctcgacga gaaggccgag cagacctccg
     1801 ccgacgcggt caacgaggcg gtcaaggcga agctggacaa gcagctcacc ctgctggagt
     1861 cctcgcccgc cgaggacaag gactcggtcg ccctcaacgc ggcgacggcg aagaagtacg
     1921 gcctcaccgc cgagtccacc ctcgccgacc tgaaggaggc cgcgcccgag ctggtgatcg
     1981 gcggctcgcc cgagttccag acccggcagc agggcctcaa gggcctggag gcggtctacg
     2041 ggctgacgtt caagtccttc aaggcgctgg acgcgggcgg ccccctgacc caggcggccc
     2101 tcgcgcagaa cgaggtccag gcggcggacg tgttcaccac ggacccgacc atcctcaagg
     2161 agaagttcgt cgtcctgaag gacccggaga acctcttcgg gtacgccaac gtcaccccgc
     2221 tggtccgcaa ggacgggctg ccgcaggagg gcgtcgaggc gctgaacgcg gtctccgcga
     2281 agctggacac caagacgctg ctcgacctgg acgcccaggt gcagctggag aagaaggacc
     2341 cgctggacgt cgccaaggcc tggctgaagt ccgccggtct cgtgtgagac ccgtcacggg
     2401 gtgcggcgga gcggtccgcc gcaccccgcg ggctcatccg gcggcggccg ccgcctgcgc
     2461 gatcagcagg tcgatcagcg cgatcagcac gtcccgcgag gactcgcgct cccgcgcgtc
     2521 gcacagcagc acgggcacgt ccgccggcag cgtcagcgcc tcccggatgt cctccaccgg
     2581 gtaagggtgc tcgccgtgga agccgttgac ggccaccacg aacgggatgc cccgccgctc
     2641 gaagaagtcg atcgcggcga agctcgactt gggccgccgc acgtcgacca ggaccaccgc
     2701 gcccagggcg ccgtgagcca ggtcgttcca catgaaccag aaccgctgct gccccggcgt
     2761 gccgaacagg tacagcacca ggtcgccgga cacggtgatc cggccgaagt ccatggccac
     2821 cgtggtgaca cgtttctcct cgacgccctc caggtcgtcg acgtccaggc ccgccatggt
     2881 cagcggctcc tcggtgcgca gcggcctgat ctcgctgacc gagccgacca gggtcgtctt
     2941 gcccacgccg aaaccgccgg cgatcaggat cttgaccgtg tcgggcgcgc cgccgtcggc
     3001 ggacgcccgg gagacggtgt cagagccggc caaggccttc cctcactttc tgcagcaggt
     3061 ccggatccgg ggtggtgacg ggacgcgggg gacggacggt gatccggccc gcttccagca
     3121 ggtcgcagag catgatgacg accacgctca ccggcaggtc gagccgcgcg gccagctcgg
     3181 ccaccgccat ggggcggacg cacagccgca ggatccgcgt gtgctcgggc tgcggccggg
     3241 cggcggtctc gggctgcggg tcggccgtcg tcaccgtcgt gatgagcgtg aagtcggcgc
     3301 ggctcggccg ggtgcggccc ccggtcaggg tgaacggccg taccagccgg cccgaagggt
     3361 cgctcccgcc cacctcacac gccggggtct tcggcgggac cgctggtctc ccgcggggcc
     3421 gcgctgaggt gctcgccgat cttcttcacc agcatgttca tctggtacgc gaccacgccg
     3481 acgtccgcct tcgggccggt cagcaccacc agatgggcgc cgggtcccgc cgaggtgagg
     3541 atcaggtagc tgtgcgccat ctcgatgagc gcctggcgca ccgggccgcc gcggaagtcc
     3601 atgctgacgc ccttgctcag gctcatcaga ccggacgccg tcgcggccag acgctcggcg
     3661 tcgtcgcgaa ggaagccggt ggacttggag accaccaggc cgtcctcgga gagcaccacg
     3721 gcctggttca cgtcggcgac ccgttccacg agtccggtca gcagctggtc cagctgggtg
     3781 tgggtggcgg gcagggggcg tgtcatggcg gtgttccttc gtcggcggtc ggcggtcggc
     3841 ggtcggcggt cgggcggtca gcggtcggcg tcagcggtcg gggtcgggtg cccggaggcg
     3901 ggcgcgggca cgcggggcgg cccgtcctcg ggcccgtcgt cgacggcgcc ccgcgcccgg
     3961 agcgtgccct gctggaaaca ggccagggag gaggaggcgt gctcggcggt gaactcgtcg
     4021 tcgcacgggt cctcgacgga gggctcctcg agcagctcgg cggcgaggct ggtctgcggc
     4081 acgcgccggg ggagcggggc gagaccgccc ttgcgggcgg tgcggctgcc gttcggctcg
     4141 ggcgcggcgg gcttgtgcgg ggtgccggcg ccgcccggcg gggtcgcgga ggcggtcggt
     4201 ggcatcgcgg tgtctccgtc cgcgggggcg gatccgaccc gtgccgagcc gggaatgccc
     4261 tgcgtagggc gggagccggc acgcgcggcc gcgggaccgg ccgccgcggg acccatgtcg
     4321 ctgccgccgg ccgcggaccc gtccccggcg gccccaggcc cgtccgtggt gtcgtcccgg
     4381 ccggcagggg cgtcctcgcc ggtggtgccc gagccgccac gcgtcacgcc ggaccgtccc
     4441 gccgcgccgt cggcgccggc gcccgcggtg ccggagccgt ccggtgcgga cccggcgtcg
     4501 ttcgccccgg ccgcggcgcc ctccgccgcg gccttgcgcg ccgcgcccgc acggtcccgg
     4561 gtcgggaggg gacgcagcgg ggacgaacca tccctcgggg aggcgccctc ggcggcggac
     4621 gcctcccgcg gcgcgtccga cggctcgtcg gtcacgacga ccacctcgtg cgggaccagc
     4681 acgatcgccg tcgtcccgcc gtacggcgac ggacgcaggg tgaccgcgat gtcgtggcgg
     4741 tgcgcgagct gggagatcac gaacatgccg agccgcaggt cgtcggcgag ggccaccacg
     4801 tcgaactgcg gcggctcggc caggtgggcg ttgagggagg cgtagtcctc ctcggacatg
     4861 ccgagccccc ggtcctcgat ctcgacggcg aggcccttgg cgaccatcgc cgcccgcacc
     4921 gtgacggggc taggcgccgg cgagtacacc gtcgcgttgt cgatcagctc ggcgagcaga
     4981 tggatcacgt cggccaccgc gggcggcgcg agcgacacct cctcgtcggc gtacacctcc
     5041 acccgctggt actcggcgac ctcgcccacc gcgctgcgca ggatgtcgat cagcgcgacc
     5101 ggttcgctcc aggtgcggcc ggggcgctcc ccgctgacga tgaccaggtt ctcctcgtac
     5161 cggcgcaact ggctggcggc ggagtcgagt tcgtacaggc ccttgaggac ctcggggtcg
     5221 gtgtgccggc gttccagcgc gtcgagcttg ctgagctgga ggttgaccag gttctggctc
     5281 tgccgcgcga tgcccaggat gatcttctgg aagccgcgcc gggtgtcggc gagttcgacg
     5341 gcggtgtgca cggcggtgcg ctgcgcggtg ttgaacgcct gcgccacctg gccgagttcg
     5401 tcgtggccgt agtccagggg cgtggtcgcc gactcggggt cgaccttctc accgcgctcc
     5461 agccgggcca ccacgtccgg cagccgctcc tgggccaggc cgagggtggc cagccgcagt
     5521 ccgcgcagcc ggcgggacag cgagcgggtg atgcgccagg acaggaccac gcacagcagc
     5581 agcgcgagca gccccgccgc gctcagcgag ccggccgtca ccagcaggcc gcccgcctcg
     5641 tcggcactgc gggtgagcag tgcgtcggtc tgctgccgga tcatcgcgct gtactgcggg
     5701 gtgaccttgt ccatggcctc ggcccaccgg tcacgcaggt ccggcagttc gacctcctgg
     5761 gcctccccct cggccggggt ggccagcacc tggtcctcca ccgcctccag cgcgcgccac
     5821 tcggggctcg acaggatccg ctcggtctgc gtcttcaggt cgccgcccag tgccggcttg
     5881 atctggtcgg cgaccagcca gcgccgggtg tgcaccagct cggcgaactc ctgccggcgc
     5941 tcggcctcca gacgcccgga cggccaggcg agggtgagca gcgcgtcctc ccgggacatc
     6001 agctccgccg cgtgctccag cgacaccagc ggctgcgcct gggaggtgag gtcgccgtcg
     6061 tcgacctggg acagctcctg gaaggcgtgg atctggtcgt cgatgaccga cgtgtactgc
     6121 tccagcgcct cctcggcggt gatgtcgcgc gggtcgtcga tctggtcgcg gtagtactcg
     6181 aggctgccca ccgagccgag caccgagtac agccggtccg agatgcgcgc cggagcctgc
     6241 gcgatcgcgt cggcctgccc catgagccgc gccacggacc ggtcggtggc gcgccgctgg
     6301 gtgaccagcg cggaccgtga accgtccggt ccggccagcc agtcggcggt gagcgcccgc
     6361 tcccgctgga ggtcgagcgc ggcatacgtg cccatcgcgc cggtggaccg gctcagctgg
     6421 gtctgcgacc gcagctccag accttcggag aacatgcgga tcgtggtcag ggcccacagc
     6481 gcggcgaggg tgacgcaggg caccagggcg agcaggatca gcgagaggcg tatggagccg
     6541 agacggcgcc gggcacctgt ccgtcgagac atcgtggtcc tagagctgtc gggtggtggg
     6601 aacggtacgc acggcggccg tcagcgggta ccggcggcgg cgaaaccggc gaccgagtcc
     6661 gcctccgcct tcgtgacgaa cgccggcccg gtgaggacgg gcgcggcccc gccgccgctg
     6721 acgttgccgt tggtccggta cagccacagc gcgtccacgg cgaggtagcc ctggaggtag
     6781 ggctgctggt cgacggcgaa gcggacgttg ccgccgcgca cggcgtccac cagttcctcg
     6841 ttcaggtcga aggtggccac ctccgccccg ctgtccgcct cggccgccgc gtccacggcc
     6901 aggagcgcga aatcggcgcc gttggtgacg acctggtcga tggaggggtc ctggcgcagc
     6961 ttggccgtga ggatgccgga gacggcccgc tcgtcggtgc cgtccacgta caggttctcg
     7021 ctcgtgccgc ggaacgtctt cttcacaccg gcgcagcgcg cctcgagacc gacgttgccc
     7081 tgctcgtgca ccaggcacag cgtgtgctcg gccttcagct ggttcagctt ctcgccgacc
     7141 gcgcggcccg ccaggctctc gtcctggccg aagaacgtca gcaggccggc cttcttccag
     7201 gcgtccgcac ccgagttgag gccgaccacg gggatgtccg cggcccgcgc ctcgttgacc
     7261 gggcccttca tcgcctgcgg cttggccagg gtgagcgcga tgccgtcgac gccgtcgcgg
     7321 acggcctggc gcaccaggtc ggcctgtccg gccccgtcgg ggtcgctgag gtaggtcagt
     7381 tcgatgccgt ccttcgcggc ggcggcctcg gcgcccttgc gtacccggtc ccagaactcg
     7441 tcgccctcgc tgccgtgggt gaccagggcg acccgcaggt cccctgagcc gctcacggag
     7501 cccgtgccgt cgtccccctc gtccgcgccg gaggaggagc aacccgccat cagcagagcg
     7561 gtcgcggccg ccaggaccgc ggttcggcgt ctcggggtgc ggcgggacgg gggacgagtg
     7621 ttcatggaga gcgcggacct cgctgtgcgg cagagctaag tgcaggggcg ggacaccggc
     7681 ggatacggac gccaccgtga ggtgcggccg tccgggtgac cctcgctggc cggagccaac
     7741 cgcgtggaac cactggtcgt caagtgaaca tccacgcgaa gtgaggtgcc gctgccgcat
     7801 tgtgatgaac cgtgagaacc tgcgaagcgg aagtgctggc tccgtacggc gcgaggaggg
     7861 cgcgcatacg gatacctcgc gtgctgtttc accccgcggc gtacgccctg tatgccggtt
     7921 gtgttcaact gggcctgttc atctgggtga tgaacgtcag cgcaccgtga gttatcgtgt
     7981 acagggcgtt aaaaacaaac ggcatgggcc gtagctttcc ggccatagga gtgcagtcga
     8041 tggcaaggca ggtacgcgcc gagaagaccc gcgcgacgat catcacggcc gcggccgacc
     8101 tgttcgaccg gcagggctac gaagcgacca gtctcagcga catcgtcgag cacgcccgcg
     8161 tcaccaaagg ggccctctac ttccacttcg ccgccaagga ggacctcgcc cacgccatcc
     8221 tggaactcca gtccgtgacc tgccaccggc tcgcccgcga caccggcgcc cgcggccgca
     8281 cgtcgctgga ggcgctgatg cgcctcacct tctgcctggc ccgcatgtcc gccgaggacc
     8341 ccgtgctgcg ggccgggctc cggctggcca ccggcgtcac ccggccgcgc ccgccgctca
     8401 gccacccctt caccgagtgg ctcgacatcg tctcggcccg gctggccgcc gccgtcgagg
     8461 aggccgacgt ccacccggac gccgacatcg acgtcgtcgc ccactccctg gtctgcttct
     8521 tcgtcggcac ccgggtcgtc ggccgcgccc gcgaacccgt cacccgtcag ccccgccgca
     8581 ccgccgagat gtggcagctc ctcatccgcg gcctggtccc cgtcacccgc cgcgcccgct
     8641 acctgtccct cgccgcccgg ctggaacggg agcccgcccc gctgtgacgc ccggcgcgcg
     8701 ggcgcccggc gggttacggt gagacccatg cccgacaccc ccgccggtcc cgtgatcgtc
     8761 gccgacgagc ccggcacctt cccgtacggc gtgctggccg agcgtcaccc cgcgatcctc
     8821 cgccaggtcg ccgccgacac cccctacggc ccggagcagc gccgcgcgct cgacgccctg
     8881 ctggcgaact gcaccgaggg cgccgtcacg cccctgcccg ccggcgccca cgaccgcgac
     8941 cgctgggccg cctggggcat ggacgaccac gccggccgct cctggcacga cgtgccctgg
     9001 ctgtggtccg agagctggtt ctaccgccaa ctgctccagg ccgtcggcta cttcgagccc
     9061 ggtccctggc agggcgtcga ccccttccgc cccgccaagc tcgccgagct cgacgcgccc
     9121 gccacggacg aggaactcgc cgcgctcgac accctcgacg acctccccga ggacgaacgc
     9181 gcccgcgccc tgctgcacgg ctccctctgg ggcaaccgcg ccgacctggg attccgcatg
     9241 tccgccgagg gcgccgagga gaccgccgcc gtccccgccc tcgtcgccga cgacggcgag
     9301 cgcctgtggt ccctgctcga cggctccccg gacggcaccc tctgcctggt cgccgacaac
     9361 gccggccgcg aactcgtccc cgacctgctg ctgatcgccc acctgctcgc ccacgggcgt
     9421 gtcacccggg ccgttctgca cgtcaaaccg cacccgtact acgtctccga cgccaccacc
     9481 gccgacgtcc tcgacgccgt acgccgcctc accgccgcca agggcgccgc cggggcgtac
     9541 ggacacgccc tgcgcgccgc cctcaccgac ggccggctcg aactgcgcgc ccacccgttc
     9601 tcgtgcgcgc ccctgcccta cgccgacatg ccggacgacc tgcgtgccga cttcgcggag
     9661 gccaccctca ccgtcctcaa gggcgacctc aactaccgcc gtctcgtggg cgaccggtac
     9721 tggcccccga ccaccccgtt cgccgacgtc accgcctact tcccgggcgc ggtcgccgcc
     9781 ctgcgcaccc tcaagtccga cgtgatcacc ggcctcgccc cggagacgga ggcggcgctg
     9841 gacgcggagg agagcgggcg ctggcgcacg agcggcaccc acgcgctgat ccaggtacgg
     9901 acctgatccc ccaactcccg tttccgcacg gtttcacgcg aaggtgtgat caccgggcgg
     9961 gccgcggatg cggccggagc ggcacgggta gcccccggcc atgacgcagc ccttcgaact
    10021 cccgcacttc tacatgccgc accccgcgcg cctcaatccg cacgtggacc aggcccgggc
    10081 ccactccacg gcctgggcgc gcgagatggg catgctggag gggagcgggg tctgggagca
    10141 ggccgacctc gacgcgcacg actacggcct gctctgcgcc tacacgcacc ccgactgcga
    10201 cggccccgcg ctgtccctga tcaccgactg gtacgtgtgg gtgttcttct tcgacgacca
    10261 cttcctggag aagtacaagc gcacccagga ccgcgtcggc ggcaaggccc acctggaccg
    10321 gctgccgctg ttcatgccgc tggagccggg gacgcccgtg cccgagccgg agaacccggt
    10381 cgaggcgggc ctcgccgacc tgtgggcgcg gaccgtgccg gcgatgtccg ccgactggcg
    10441 ccgccggttc gccgtcgcca ccgagcacct cctcaacgag tccctgtggg agctgtccaa
    10501 catcaacgag gggcggatcg ccaaccccgt cgagtacatc gagatgcgcc gcaaggtggg
    10561 cggcgccccc tggtcggccg gtctcgtcga gtacgccacc gccgaggtgc cggccgccgt
    10621 cgccgggacc cgtccgctac gggtgctcat ggagacgttc tccgacgccg tgcacctgcg
    10681 caacgacctg ttctcctacc agcgggaggt cgaggacgag ggagagctca gcaacggcgt
    10741 gctcgtcctg gagaccttct tcggctgcac cactcaggag gccgccgacc tcgtcaacga
    10801 cgtcctcacc tcgcggctgc accagttcga gcacaccgcg ttcaccgagg tgcccgccgt
    10861 cgccctggag aacgggctca ccccgcccga gaccgcggcc gtcgccgcgt acgcgaaggg
    10921 attgcaggac tggcagtccg gcggccacga atggcacatg cgctccagcc gctacatgaa
    10981 cgagaacgcc cggcccggcg ccccctggca gtctgtcacc ggccccggcg cgtccgccgc
    11041 cgacgtcggc gcgctgctcg cccgcgccgc ctcggagcgg ctgcgcccct accggcacgt
    11101 gccgtaccgg aaggtcggac cgtcggtcgt cccggagatc cggatgccgt tcccgctgtc
    11161 cctcagcccc gccctcgagg gctcccggcg gcatctgctg gactggtcgc accgcatggg
    11221 catcctcggt gagggcgtct gggacgagga caagctcgcc agttgcgacc tgcccctgtg
    11281 cgcggccggc ctggaccctg acgccaccca ggagcagctc gacctcgcct ccggctggct
    11341 ggccttcggc acctacggcg acgactacta cccgctggtc cacggccacc gccgcgacct
    11401 ggccgccgcc cggctcacca ccgcccggct gtccgcctgc atgccgctcg acggcgagga
    11461 ggtgcccctg ccggccaacg cgatggagcg gtccctgatc gacctgtggg cccgcaccac
    11521 ggccgggatg acgcccgagc agcgccgccc gctgcggacg gccgtcgaca cgatgaccga
    11581 gtcgtgggtg tgggagctgt ccaaccagat ccagaaccgc gtcccggacc ccgtggacta
    11641 cctggagatg cgccgcgcca ccttcggctc cgacctcacg ctcggcctgt gccgcgccgg
    11701 acacggcccc gcggtcccgc cggaggtgta ccgcacgggt ccggtgcgct ccctggagaa
    11761 cgcggcgatc gacttcgcct gcctgctcaa cgacgtgttc tcgtaccaga aggagatcga
    11821 gttcgagggg gagatgcaca acgcggtcct cgtcgtgcag aacttcttcg gcatcgacta
    11881 cgcgaccgcg ctgcccgtgg tcgcggacct gatgaaccag cgcatgcggc agttcgagca
    11941 tgtcgtcgag cacgaacttc ccgtcgtcta cgacgacttc cagctctccg aggaggcgcg
    12001 ggcggtcatg cggggctatg tgaccgacct gcagaactgg atggcgggca tcctcaactg
    12061 gcaccgcagc gtggaccggt acaaggacga gtacctgtcc gggcgggtgc acggtttcct
    12121 gccgcaccgg tccccggcgc ccccggtcct cgtctgacgg cgggccgccg tggaaccccc
    12181 cgcgctccgc ccccggccga tgcccggcga ccacgccgga ccccggccgg accccgctcc
    12241 cgccgtcccc gaggagccgc ccgccgggcg cccgcgaggc cggcgggcgg cggcggggct
    12301 ggccctgctg ctgaccggag ccgccctggg cgtcctggcc gccgcgtgga ccgcccccgc
    12361 cccgccgtcc gggccggccc tctccgcccg gctcggggtg gaggtgaccg acgccggccg
    12421 gccgggcgcc ctggtggtcg gcgtgcagaa ccccggcccc ggacacacgg ccggcctccg
    12481 cgagggcgac ctgctgctcg ccgtcggcgc cacccgcgtc gacacggcag cggacctggc
    12541 ccacgaggtc ttccgcatcc caccgggcac ccccgtccgc ctgaccgtcc ggcatcccac
    12601 gggcggctac cagcagctga cggcggttcc cgggatcctc acgtagggct gccgcgaggc
    12661 gcggggcccg cggcggcggc ctccggcgcg cgtgtcccgc ccacgggaac tgggagccgt
    12721 gccgtcgcct gcggacgccg gtgcacgcag gacggacggg gagagtgggc gtacgcggtt
    12781 cgtccgcgtg ctgtccggtg ccacacggct tgctgcgtgc ctgccggacg cggcgacgtc
    12841 cgtgggccag ggcctccgtg cgcccacccc ttcgcggacg gcgccgccgg tgcgcggtgt
    12901 gtccgtcggc ggcaatgtgt gggacgggca tgtccgcttg tctcgcgtgc cgggcgtccg
    12961 gtgagccgtc cggtgctccg gggtggcacg gcgtgcctgg ccgggcggtc agggagggcg
    13021 ctccggcttc ccgggcggcg gcgaccgccc tgccgcggcg cgtggcgcgt ccggcgggcg
    13081 cggcgggtgg tgaccggcgt ggagtcgggg cggagcgccc cgcgtgcaca ccggtgcgcc
    13141 gcgggggtgc ggcccgtgaa tgcgcggctt tgcaggcgct ccggggcgtc cggcccccgc
    13201 gccgtaccgg aagcggtaca ggcgatcccg cccccgggcg gggcgactgc gggggcaacc
    13261 ccggcaaccg gctcgcgccg tacccgttcg gcgggcagga tgctgcccgt agccccgacg
    13321 tccgcccctg ggaggcaccc ggatgaccgg caccgcgccc gtgcccttca ccgccgacga
    13381 ctacaaggac cgtatggacc gggcggcgcg gcaggccgcc gacgccgggc tcgccgggct
    13441 gctcgtcgcg ccgggcccgg acctggtgtg gctcaccggg tacgcgccgc ccgccgtcac
    13501 cgagcggctc accctgctgg tcctggccgc cggccgggaa cccgtcctcg tcgtccccac
    13561 cctggaggcc ccggacgccg agaaggccac cggcgcgccc gccctcgccc tgcgcgactg
    13621 gaccgacggc aaggacccct acgccctcac cgccgccctc ctcggcgacc gggggcggtt
    13681 cggcgtcagc gacaacgcct gggcgctgca cctgctggga ctccagcagg cgctccccgg
    13741 gacctcgtac gtctccctca ccgacgcgct gccgatgctg cgcgccgtga aggacgccgc
    13801 ggagctggag cggctcgccg cggccggcgc cgccgcggac gccgcgttcg aggagatcag
    13861 gaaagtccgc ttctccggcc gtccggagtc cgaggtggcc gccgacctcg ccgcgctgct
    13921 gcgccgcttc ggccactccc aggtcgactt caccatcgtc gcctccggcc ccaacggcgc
    13981 caacccgcac cacgaggccg gcgaccgccg tatcgagcgc ggcgacatgg tcgtcctcga
    14041 cttcggcggc ctgaaggacg gctacggttc cgacacctcc cgcacggtgc acgtcggtga
    14101 gcccaccgag gaggagcgcc gggtgcacga cctggtgcgc gaggcgcagg aggccggctt
    14161 ccgcgcggtg cggccgggcg cggcctgcca ggacgtcgac cgggcggccc gcgcggtcat
    14221 cgccgacgcc gggtacggcg agtacttcgt ccaccgcacc gggcacggca tcggcgtcac
    14281 cacccacgag ccgccgtaca tgatcgaggg cgaggagcgg ccgctcgtcc ccggcatgtg
    14341 cttctccgtc gagccgggcg tctacctgcc gggtcggttc ggggtgcgga tcgaggacat
    14401 cgtgaccgtc acggaggacg gcggacggcg gctgaacgac acggagcggg ggatggtgat
    14461 agtcgactga gcggcaccga ccggcccctc ggccccgtcc ccaccctgcc tctcccgaac
    14521 ggctacggcg cgaccatgac ccaggcaccg acacccaccg ttgacaccgt ccgccgactg
    14581 gcccggtccc tgctcaagga cagcgggcac ggcacgggcg cgtccgccgc cgccctcgat
    14641 gtgcggctcg cgggcgacgg cgccgacccc accacctggc tggtcggcac ccggtacgtg
    14701 ctgcacctcg ccccggaccg cgcgaccggc gtgcggtggc gccgcgagct gcgactgcgc
    14761 gaggtggtgc gcccgcacgt gtccgtggcg ctgcccgtcg gggtggcgca gggcgagtgg
    14821 gcgcccggct tgccgtgcac gctggagacc cggctgcccg gcggcacggc ggaggagaac
    14881 accgtgtccg ccgtcggcga gaccgacctg gcgggcctgc tcaccgggct gcaccaggtg
    14941 cccgtacggc aggccgaggc gctgggtgtg ccccgcgtgc cgccgcgctc gctggagacc
    15001 ctgcggcggg cggccgggga ggccgtggaa ctgctcgaca aggccgacga gttcgaggcg
    15061 gcgcggctgc gccagttcac ccaggccgcg acggtgcagc tcgccgcgca ggccggctcg
    15121 gtggtgctgg tgcaccacgc cctcacgggc ggcaacctgg tcgtcggcgc ggacggccgg
    15181 gtgagggggg tgctcggctg ggacacggcg gtggtcggcg acccggccga ggacatcgcg
    15241 ggtctggccc gcgccgtcgg cgcccccgcc gccgtccgcg cggccacgct ggcgggctac
    15301 ggcgcccgcc cctgtctgcg cggcctgtgg ctggcccgct gcgactgcgt catccacctc
    15361 gccgaggcgc tcgtccacaa cgccacggcg tccctgccgc tgctccgcac ccgcctccgc
    15421 cgcgcctggg agcccatcat gctggaacgc gtcaccgacc tccgggacag cgacgcggcg
    15481 ccgtgacccg gcacaccgcg ggcgtcccgg ggcgcggagc gggcggaccc gccccgcgcc
    15541 cgcctcactc ctgaagcagc accaccgccg actccccggg cagccgcagc agaccgtccg
    15601 cgcccggcac gtccaccggc tcccacgccg ccaggacgcg ggcctcgcgg gagcccaggg
    15661 ggatgtcggc cggttcggcg cccaggttca cggccacgcg gacgtcgccg cggcggaagg
    15721 ccagccagcg ccggtcctcg tcgtaggcca ccttggtgtc ggcgaggtcc gggtcggtga
    15781 ggtcgggctg ctcgcggcgc accgcgagga gctgtccgta ccaggccagc atccgggcgt
    15841 gcggctcccg ctccggctcg gaccagtcca ggcaggagcg gtcacgggtg gccgggtcct
    15901 gcgggtcggg cacgtcctgc tccgcccacc cgtgcgcggc gaactcccgc cgccgcccct
    15961 ggctgaccgc cttcgcgagc tccgggtcgg tgtggtcggt gaagaactgc cacggcgtgc
    16021 ccgccgccca ctcctcgccc atgaacagca tcggggtgaa cggcgcggtc agtgtcagcg
    16081 ccgccgcgca ggccagcagg ccgggggaga ccagcgcgga cagtcggtcg ccctgggccc
    16141 ggttgcccac ctggtcgtgc gtctggctgt agcccagcag ccggtgcgcg gccacgcggg
    16201 tgcggtcgag cggacgcccg tggtgccggc cgcggaagct ggagtaggtg ccgtcgtgga
    16261 agaagccccc ggtgagcgtc ttggccacgg ccgccagcgg ggcgcgtgcg aagtcggcgt
    16321 agtagccctg cgactcgccc gtcagggcgg tgtgcagggc gtggtggaag tcgtcgttcc
    16381 actgggcgtg gatgccgagg ccgccccggt cgcggggggt gatgacccgc gggtcgttga
    16441 ggtcggactc ggcgatcagg aacagcggcc ggccggtgtc ggcggccagc tcgtccacgg
    16501 cctgcgacag ctcctccagg aagtggcgcg cgcgggtgtc caccagcgcg tgcaccgcgt
    16561 cgagacgcag cccgtcgatc cggtggtcgc gcagccacgc cagcgcgctg tccacgaggt
    16621 aggcgcgcac ctcgtccgag ccgggcgcgt ccaggttgac cgccacgccc cacggcgtgt
    16681 ggtgcgtgtc ggtgaagtac gggccgaact gcggcaggta gttgcccgac gggcccaggt
    16741 ggttgtgcac cacgtccagg acgacgccga gccccagccc gtgcgcccgg tcgacgaacc
    16801 gtttcagccc ctcgggcccg ccgtacggct cgtgcacggc ccacagtgag acgccctcgt
    16861 acccccagcc gtgccggccg gggaaggggc acaccggcat caactccacg tgggtgacgc
    16921 ccaggtcggc gaggtggccg agccgttcgg cggcggcgtc gaaggtgccc tcgggggtgt
    16981 aggtgccgac gtgcatctcg tacagcaccg cgccgggcag cgggcgtccg gtccattcgg
    17041 cgctccactc gaagcggtcg tggtcgacga cggcgctgag cccgtcgggg ccgtcgggct
    17101 ggcggcgcga cctcgggtcc ggcagcaccg gaccgtcgtc cagggcgaag ccgtaccggg
    17161 agccgtcgtg cgcctcggcc tccccccgcc accacccctc ccgctcggga tcgcgctcca
    17221 acgcgcgcgt gacgccgtcg caccggagcg tcactcggcc ggcctgtggt gcccacacct
    17281 cgaactgcac ggacggttcc ccttcgtctg ctcaccgtga tgaagcgcct ccatcgtgcg
    17341 gcatcggaga tcaatacgcc gggggatccg ccgttttgcg gcgggtgtcg cccgaggtgc
    17401 gcgtgccggg gccgtggagg gagcgggcgt accccctcac agacggggtc ctgtcctccg
    17461 tttacggggt ttctggacag ctcgcccccg gctgtccgac aatcgaccgc gtgacgtcgt
    17521 ccttcgagtt ctccacgtac cccgcgcggc tctccgacgc ggagcgcgac aaggcgctga
    17581 gtgtgctgcg ggacggcgtc gccaagggcc gcctctccca cgacacgttc atccggcgca
    17641 tggaactggc gctcgtggcg cggcgcgccg acgaactcac cgcgctcacc gccgacctcc
    17701 cgcgcgagaa ccgcttctcg cgcgtggtgt tcggctcggt ggaggcggta tccgggttca
    17761 ccgtgcggct gcgccgtgcc tggcgggccg agaagctgcc gaagctgctg ctgccgcacc
    17821 ccgcgcacgg acacccgctg cggatagggc gcgacccggc cagcggactg cggctcaccc
    17881 acgagacggt ctcccgcgtg cacgccgaac tcacccgtca gggcggcctg tgggtgctgc
    17941 gcgacctcgg ctccaccaac ggcacgacgg tgaacggccg tcgggtggtc ggcgcggccg
    18001 tggtccgcga gggggaccag gtgggtttcg gccggatcgt ctaccgtctc tccgtcaact
    18061 gacgggcgta tacaccttgt tggtgggtaa cggtgttgac gccgccccga gcgcgtgact
    18121 gactgtaggg gtacctcgca ctccccgtac ttcctgctcg aagacctccg cgcttcccgc
    18181 acggcctgta cttccggtgg acgacggcgt cgcttcgtgg aggtgtgacc tgacgcccct
    18241 cctgagctat ccgaccgtcg acgaactcgg cgcgcgggcc gcctccctcg ccgcccgcca
    18301 tccccgcgac gcgcgtctgc gccgcgtcgg cgtctcccgc gcgggcaccc ccctgtggct
    18361 gctcggtgtc ggccacggaa gccgccaggc cctcgtcgtc gcgggacccc acgccaacga
    18421 accggtgggc ggcgccaccg tgctgcggct ggcggagcac gccctcgccg accgccgctt
    18481 caccgacggc gccgacgtca cctggaactt gctgctctgc ctcgaccccg acggcctgcg
    18541 ccacaacgag cgctggctga ccggccctta caccctcggc cgccacttcc gtcacttcta
    18601 ccgccccggc ttcctggaac agcccgagtg gctgccggac ggcgccgcgt ccgccgcgct
    18661 gccggagacc cgcgcgctgc tcgccctcca ggacgagctg cgccccttcc tccagtgctc
    18721 cctgcacggc gtggacgtcg gcggcggctt cgtcgagctc acccacgagc tgccgggcct
    18781 cgaccgccgg gtcgccgccg tcgccgcccg cctcggcgtg ccgcgcgaac tcggcgcgta
    18841 cgacgcgctg tactggcccg gtctcggccc cgccgtctac ctcataccgc caccgcggcg
    18901 ccgggacctg gccgccgcca tcaccgaggc ggccgtggag tcgacgtggt accaccccta
    18961 cgggtacggc acggtcaccg cggtcgtgga ggcgccgatg tggggcgtcg ccgccgtcgg
    19021 gaacggcgcc ccgcaccccg acccggacgc ggagctgcgg tccgtcagcc gcaccctgcg
    19081 ccgggacacc gggctgctcg gtgagctggc ggcgcggatc cgcccgtacg tcgcgggcgt
    19141 gcccgacgcg gaccggctgc tcgccccggt cgaggactac ctcctggtct gcccgggcct
    19201 cgcggacgcc tgggaccccg actgcgggaa cgattctgcg cgtccgttgc cgcccatgac
    19261 gaccgcccac ctggccgcgc tgcgcctcgc gggaaggcgc ctcgccctgc gcaccgccgg
    19321 tctgctgcac cagctcgtca cccgtgccgg gcgcgacccg gccgacgcgc tgcccgagct
    19381 gaaccggctg atggacgcgc gttgcgcgga cctccgggac acgctcggcg cccgctggat
    19441 ccccgtggac cgccaggcgg agtaccaggc ccgggtgatc cgcgccgtgt gcgccctggc
    19501 cgtacggagg acacccggag cctcccgttc gggtgagccg ggctggggcc ccgggcccgc
    19561 cgtgccgatg caccgggaat gacgcacacc tcagtgaaga cggtaggggc ggggctgtcc
    19621 gccgccgccc tcctcgtgct cgccggcgcg acgcccgccg cccacgcgga cacctcgccg
    19681 gaacccggga actggctgat gctcagcgtg agtcacgggg aggccccggc ggccggggcg
    19741 gagggcggca cgctgctgcg gtgcgacccg cccggcggtg gccacccgca cgcggaggag
    19801 gcctgcgcgc agctgtcggc cgcggacggc cgcatcacca ccctccccgc ggagaacacc
    19861 ctctgcccga tgatccacgc cccggtgacg gcccacgcgg agggcgtgtg gcgcgaccgc
    19921 ccggtcacct ggtcggagac cttcccgaac acctgcgccc tgcgtgccca cacgggggcg
    19981 ctgttcgcgc tcgacgggac gtgagacgca gggtgccgtc cgacgggcgc gggaggacac
    20041 accggccggc gtgccgcttt cctcggtgag ggggagctga ccctgacggc gagtcaggcc
    20101 acccagggcg ccgcccgacg ccggggtcct ggggcgtcgg acagccgacg gcccgccctg
    20161 ctgcccggct cgcgccggct caccctgggt gcttcggcgc gccttgccgg ggtggccggc
    20221 ggggcgacgg cgtctgcatg gggcctggtg cccggccgtg agagccgggt ggccgggttc
    20281 gtagggcggc gcctcgcact ggcgtgctgc ccggttcgcg ctgggtgctn nnnnnnnnnn
    20341 nnnnnnnnnn nnnnnnnnnn ntcggcgcgc cttgccgggg tggccggcgg ggatgacggc
    20401 gcctgcacgg ggcacggtgc ccggccgtga cagccgggtg gccgggttcg tagggcggcg
    20461 cctcgcactg gcgtgctgcc cggttcgcgc tgggtgctcc ggcaggcctt gccgggatgg
    20521 ccggcggggt tgaggcgtct gcatggggca cggtgcccgg ccgtgacagc cgggtggccg
    20581 ggttcgtagg gcggcgccnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnccgcac
    20641 tggcgtgctg cccggttcgc gccgggtgct ccggctcgcc ttgccgggat ggccggggcg
    20701 gggttgacgg cgcctgcaca gggccagccc ggccgtgacg accgggtcgc cgggcccgta
    20761 gggcggcgcc ccgcacccga gggcgcggga cgactgcccc gcgtcccgcc cggccggggc
    20821 ggcgtgccgc cccggccccc tcacatcagc cccgcccgcg cctgccgcgc cgccgccacc
    20881 accgtgcggg actggtgttc cacctggtgg cggaccggga cccagcgggc gcggaagcgg
    20941 gtggcgaagg cgtcgctcca gtgggcgacc aggtggtcca ggcgggccgc cgcctgggcg
    21001 tcggtgtcgc gcagcgcgcg ccgcagcatc gccgccgccc gcagcggcac gcggcgcgcg
    21061 aaggcgtcca cgctgccgac gtaggcgcgg gtgccgtccg cgggaggggt gcggaccagg
    21121 tcggcggcca gtcccggcac cagctcgagc acccaggcgg ccgcccgcag cagcggaccg
    21181 tcggcctcgg tgggcggcgg ccccggccgt acgtcctcca gcacgtgccg caccgcgtcc
    21241 gcgtcccgca acagccgttc cgcgagcgcg tgcatcgcgg tgtccggcgc cgggtgcggg
    21301 gccgggtcgt cgaccaggtc gctcgcccac atcggtacct cgaccaccgc ggtcagaccg
    21361 ccgtaccggt gcgcgtggta ccaggtgctg tgccgggcgt cgtcgctcag gctcggatag
    21421 gccggggccg cctccggcgc gggcatcacg tgcacgccgg gacccgacgc gggccagccc
    21481 gccgcgtccg aggcgcccgt ctcgacgggg atgtgcagct cggccgccga cttggcgaac
    21541 ggctccgcga gcccgggcac gtcccgcgtc aactgcaccc agctgccgcc caggtccgtg
    21601 ccgtgcaggg acacctggag gaacggccgc agctcgtcga tcaccccggt cagcgcccgc
    21661 gtctccgggg gcagccggtc ggcgggcagc accgagggcg cccactccgg ctgctcggag
    21721 cctgccgggc ggaagaagcc caggtggtag tcgtacaggc tgcgcggcgc gggcgtgacg
    21781 tgcaggctcg ccccgtcggg gtccgcgcac agcaggaagt gccaggagac gccgtcacgc
    21841 agctcccgct cgagcagggt ccgccgggcc agcgccagca gcgtcccgtt gcccgcgggc
    21901 tcgttggcgt gggcgccggc cacgaccagg acggcgtgcc gggcgcgtcc cacggacagc
    21961 aggtgcagcg gccgtccccc gcgggacgcc cccacctgcc gcagcacaca cagacccggc
    22021 cactggatcg ccagcgcccg ggcggagaag accagttcgg ccaccgtcgg atagcgcgac
    22081 tcccgcagcg gacccacccc ccgtcaccgc ccgcactcgc actgcgcagt accccacggc
    22141 cgcgagacgg tgtcaag
//
