GCF_014649415.1 - 41 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_BMSZ01000002.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	NRPS,T1PKS	503	51,064	Low	valinomycin/montanastatin	saccharide:hybrid/tailoring+NRPS:Type I
Region 2.2	t3nrps-iterative,RiPP-like,NRPS,T1PKS	143,812	214,503	High	10-epi-HSAF/10-epi-3-deOH-HSAF/10-epi-maltophilin/10-epi-xanthobaccin C/10-epi-hydroxymaltophilin/10-epi-FI-2	other:other+PKS
Region 2.3	terpene	258,001	284,387	Medium	hopene	terpene

NZ_BMSZ01000003.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	NRPS,NRPS-like	1,966	78,272	Low	friulimicin A/friulimicin B/friulimicin C/friulimicin D	NRPS:Type I
Region 3.2	terpene-precursor	171,795	192,838
Region 3.3	lanthipeptide-class-iii	323,555	345,926	High	AmfS	ribosomal:RiPP:Lanthipeptide
Region 3.4	T2PKS,T1PKS,NRPS-like	394,238	499,207	High	alnumycin A/alnumycin B/alnumycin C/alnumycin P/prealnumycin/thalnumycin A/thalnumycin B/K1115A/1,6-dihydro-8-propylanthraquinone	PKS:Type II

NZ_BMSZ01000004.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	lanthipeptide-class-ii,lanthipeptide-class-iii	11,181	42,382
Region 4.2	NI-siderophore	82,505	112,283	High	desferrioxamin B	other:other

NZ_BMSZ01000005.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	oligosaccharide	2,667	33,645	Low	auroramycin	PKS
Region 5.2	hydrogen-cyanide	97,649	110,579	Low	aborycin	ribosomal:RiPP
Region 5.3	RiPP-like	296,276	307,622	Low	14-hydroxyisochainin	PKS:Modular type I

NZ_BMSZ01000006.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	ectoine,butyrolactone	111,919	127,128	Low	showdomycin	other:other
Region 6.2	lanthipeptide-class-ii	227,755	253,962

NZ_BMSZ01000010.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	terpene	13,497	35,710	High	geosmin	terpene:Sesquiterpene
Region 10.2	NRP-metallophore,NRPS	75,129	133,748	High	coelichelin	NRPS:Type I
Region 10.3	T3PKS	176,497	217,630	High	naringenin	PKS:Type III
Region 10.4	terpene-precursor	223,344	244,396

NZ_BMSZ01000011.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	terpene	1	28,919	High	isorenieratene	terpene
Region 11.2	NRPS,T1PKS	38,499	90,783
Region 11.3	T3PKS	168,503	209,555
Region 11.4	terpene-precursor,melanin	217,825	245,568	High	melanin	other:other
Region 11.5	RiPP-like	247,961	259,328	Medium	streptamidine	ribosomal:unmodified

NZ_BMSZ01000013.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	NRPS,transAT-PKS	128,306	192,127

NZ_BMSZ01000015.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	terpene,NRPS-like	213,435	245,727

NZ_BMSZ01000016.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 16.1	deazapurine	162,474	184,816	Low	toyocamycin	other:other

NZ_BMSZ01000017.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 17.1	NRPS-like,NRPS	1	30,070	High	stenothricin	NRPS:Type I
Region 17.2	terpene	125,905	146,984	Low	steffimycin D	PKS:Type II+saccharide:hybrid/tailoring

NZ_BMSZ01000021.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	ectoine	37,136	47,534	High	ectoine	other:other

NZ_BMSZ01000022.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	NRPS	56,339	93,590

NZ_BMSZ01000023.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 23.1	NI-siderophore	45,572	78,301	Low	kinamycin	PKS

NZ_BMSZ01000025.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 25.1	T1PKS	8,943	66,291	Low	auroramycin	PKS

NZ_BMSZ01000027.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 27.1	terpene	24,826	45,803

NZ_BMSZ01000028.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 28.1	NRPS-like	1	30,917
Region 28.2	butyrolactone	37,789	48,676	Low	coelimycin P1	PKS:Type I

NZ_BMSZ01000029.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 29.1	t3nrps-iterative,ectoine	10,277	54,324	Medium	ectoine	other:other

NZ_BMSZ01000030.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 30.1	lassopeptide	1	21,614	High	SRO15-2005	ribosomal:unmodified

NZ_BMSZ01000040.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 40.1	NRPS	1	4,585	Low	cysteoamide	NRPS:Type I

NZ_BMSZ01000041.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 41.1	NRPS	1	4,528	Low	hypeptin	NRPS:Type I

NZ_BMSZ01000046.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 46.1	NRPS	1	3,222

NZ_BMSZ01000048.1 (Streptomyces badius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 48.1	NRPS	1	3,166

No secondary metabolite regions were found in these records:: NZ_BMSZ01000001.1 (Streptomyces badius); NZ_BMSZ01000007.1 (Streptomyces badius); NZ_BMSZ01000008.1 (Streptomyces badius); NZ_BMSZ01000009.1 (Streptomyces badius); NZ_BMSZ01000012.1 (Streptomyces badius); NZ_BMSZ01000014.1 (Streptomyces badius); NZ_BMSZ01000018.1 (Streptomyces badius); NZ_BMSZ01000019.1 (Streptomyces badius); NZ_BMSZ01000020.1 (Streptomyces badius); NZ_BMSZ01000024.1 (Streptomyces badius); NZ_BMSZ01000026.1 (Streptomyces badius); NZ_BMSZ01000031.1 (Streptomyces badius); NZ_BMSZ01000032.1 (Streptomyces badius); NZ_BMSZ01000033.1 (Streptomyces badius); NZ_BMSZ01000034.1 (Streptomyces badius); NZ_BMSZ01000035.1 (Streptomyces badius); NZ_BMSZ01000036.1 (Streptomyces badius); NZ_BMSZ01000037.1 (Streptomyces badius); NZ_BMSZ01000038.1 (Streptomyces badius); NZ_BMSZ01000039.1 (Streptomyces badius); NZ_BMSZ01000042.1 (Streptomyces badius); NZ_BMSZ01000043.1 (Streptomyces badius); NZ_BMSZ01000044.1 (Streptomyces badius); NZ_BMSZ01000045.1 (Streptomyces badius); NZ_BMSZ01000047.1 (Streptomyces badius); NZ_BMSZ01000049.1 (Streptomyces badius); NZ_BMSZ01000050.1 (Streptomyces badius); NZ_BMSZ01000051.1 (Streptomyces badius); NZ_BMSZ01000052.1 (Streptomyces badius); NZ_BMSZ01000053.1 (Streptomyces badius); NZ_BMSZ01000054.1 (Streptomyces badius); NZ_BMSZ01000055.1 (Streptomyces badius); NZ_BMSZ01000056.1 (Streptomyces badius); NZ_BMSZ01000057.1 (Streptomyces badius); NZ_BMSZ01000058.1 (Streptomyces badius)

Compact view

NZ_BMSZ01000002.1 - Region 1 - NRPS,T1PKS

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Location: 503 - 51,064 nt. (total: 50,562 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase aminotransferase glycosyltransferase

IE135_RS03920: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

IE135_RS03985: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

IE135_RS33795: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: hydrolase

IE135_RS03875: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Isomerases: mutase

IE135_RS03980: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: ligase synthase

IE135_RS03885: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

IE135_RS33790: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000342.4	0.60	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0000307.4	0.59	NRPS	AbT1	Aureobasidium pullulans
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000357.5	0.58	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001758.4	0.57	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001249.5	0.57	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001240.4	0.57	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.64	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000342.4	0.64	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001249.5	0.62	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001240.4	0.62	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 33.62 out of 36.53

Confidence: strong

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 24.32 out of 29.51

Confidence: medium

Additional weak hits (6):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.54 out of 26.85

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.42 out of 39.62

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.84 out of 21.84

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.72 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.56 out of 26.06

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.81 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 502 - 51064:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 502 - >44662:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 7749 - 51064:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS33790: X

AMP-binding (350..750): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWHCFDASLLEPVLLLGGEVNVYGPTETTVLCLT
Nearest Stachelhaus code(s):: aIle DALVFGVVLK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

IE135_RS03885: mal

PKS_AT (548..841): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 66.7%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 139.0
inactive: 76.0
Methylmalonyl-CoA: 69.6
Methoxymalonyl-CoA: 52.1
Propionyl-CoA: 38.7
Ethylmalonyl-CoA: 31.8
Isobutyryl-CoA: 28.1
trans-1,2-CPDA: 23.5
Acetyl-CoA: 20.7
fatty_acid: 19.4
CHC-CoA: 17.6
3-Methylbutyryl-CoA: 17.4
2-Methylbutyryl-CoA: 14.3
Benzoyl-CoA: 13.1

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor
DosR	Hypoxia stress response regulator

NZ_BMSZ01000002.1 - Region 2 - NRPS,RiPP-like,T1PKS,t3nrps-iterative

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Location: 143,812 - 214,503 nt. (total: 70,692 nt) Show pHMM detection rules used

t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

IE135_RS04515: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

IE135_RS04595: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IE135_RS04600: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

IE135_RS04605: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

IE135_RS04610: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

IE135_RS04670: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: aminotransferase

IE135_RS04625: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Lyases: decarboxylase

IE135_RS04530: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: synthase

IE135_RS04615: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transport transporter

IE135_RS04445: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

IE135_RS04655: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001043.4	2.03	NRPS, PKS	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365.2	1.94	PKS, other (other)	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001273.3	1.36	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	1.35	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	1.34	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000996.5	1.32	NRPS, PKS	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001726.4	1.12	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum
BGC0002509.3	1.07	NRPS	montamide A, capsimycin, clifednamide A, frontalamide A, combamide A	Streptomyces sp.
BGC0001556.5	1.05	NRPS, PKS	combamide	Streptomyces sp.
BGC0001132.4	1.02	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001043.4	0.88	NRPS, PKS	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365.2	0.86	PKS, other (other)	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000996.5	0.75	NRPS, PKS	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001726.4	0.70	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum
BGC0002509.3	0.69	NRPS	montamide A, capsimycin, clifednamide A, frontalamide A, combamide A	Streptomyces sp.
BGC0001556.5	0.68	NRPS, PKS	combamide	Streptomyces sp.
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.09 out of 20.47

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 26.21 out of 28.19

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 30.11

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 26.03 out of 30.11

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.09 out of 20.47

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 28.29 out of 35.63

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 28.35 out of 35.63

Confidence: medium

Additional weak hits (16):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.32 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.93 out of 31.73

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.60 out of 30.22

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.50 out of 27.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.74 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.43 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.61 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.43 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.06 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.05 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.99 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.82 out of 25.88

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.48 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.04 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.01 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 143811 - 214503:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS04615: pk - Orn

Search NORINE for peptide: strict or relaxed

PKS_AT (550..846): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; CE-Malonyl-CoA: 54.2%; Acetyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 128.1
Methoxymalonyl-CoA: 118.9
Malonyl-CoA: 116.7
Ethylmalonyl-CoA: 105.0
Isobutyryl-CoA: 90.2
Propionyl-CoA: 74.2
Acetyl-CoA: 71.8
trans-1,2-CPDA: 71.4
2-Methylbutyryl-CoA: 70.2
Benzoyl-CoA: 66.1
CHC-CoA: 51.6
fatty_acid: 50.1
3-Methylbutyryl-CoA: 37.7
inactive: 34.3

AMP-binding (2303..2722): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: AAWAFDVFTGDREFVVGSDVNSYGLTEATIDSAY
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor
NrtR	NAD synthesis repressor
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NZ_BMSZ01000002.1 - Region 3 - terpene

Download region GenBank file

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Location: 258,001 - 284,387 nt. (total: 26,387 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IE135_RS05005: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

IE135_RS05040: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

Transferases: aminotransferase transferase

IE135_RS04980: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

IE135_RS05045: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Lyases: dehydratase

IE135_RS05055: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase

IE135_RS05000: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.68	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002508.2	0.48	other (other)	8-azaguanine	Streptomyces pathocidini
BGC0000630.3	0.47	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000641.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.68	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002508.2	0.48	other (other)	8-azaguanine	Streptomyces pathocidini
BGC0000630.3	0.47	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000641.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

IE135_RS04995: T2TS

Domain 1 (19 - 651): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

IE135_RS05000: PT_FPPS_like

Domain 1 (74 - 366): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

IE135_RS05010: PT_phytoene_like

Domain 1 (6 - 292): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → PSPP; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

IE135_RS05015: PT_phytoene_like

Domain 1 (9 - 217): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → PSPP; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

Additional weak hits (12):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.38 out of 26.85

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.65 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.37 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.49 out of 29.38

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.72 out of 36.54

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.52 out of 29.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.50 out of 30.22

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.59 out of 29.38

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.68 out of 39.62

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.73 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.72 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
MexT	Global virulence regulator

NZ_BMSZ01000003.1 - Region 1 - NRPS,NRPS-like

Download region GenBank file

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Location: 1,966 - 78,272 nt. (total: 76,307 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

IE135_RS06260: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

IE135_RS06265: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

IE135_RS06280: Dioxygenase TauD/TfdA

smcogs: SMCOG1046: Dioxygenase TauD/TfdA

IE135_RS06330: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Hydrolases: esterase

IE135_RS06290: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: lyase

IE135_RS06300: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

IE135_RS06305: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase

IE135_RS06230: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS06240: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IE135_RS06245: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IE135_RS06250: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IE135_RS06270: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS06295: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.71	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.71	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000342.4	0.70	NRPS	enniatin	Fusarium equiseti
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.70	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.91 out of 26.33

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.13 out of 27.04

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.25 out of 27.04

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (3):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.91 out of 23.43

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.47 out of 27.55

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 22.38 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 1965 - 78272:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (D-Tyr - D-Val) + (D-Orn) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 1965 - 66116:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (D-Tyr - D-Val) + (D-Orn) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 35002 - 78272:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Tyr - D-Val) + (D-Orn) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS06230: X

AMP-binding (465..864): X

nrpys: Phe, Trp, Ph-Gly, Tyr, bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SALVFDASVLDGSLVVSGEFNGYGPTEVTIGATA
Nearest Stachelhaus code(s):: Lys DAESVGTIIK (68% 8Å match); cycHexAla DLLSVGGVFK (56% 8Å match)
Stachelhaus code match:: 60% (weak)

IE135_RS06235: Tyr - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (465..866): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: LGQAFDAAVSETTLVVAGEINAYGPTESTVCTSM
Nearest Stachelhaus code(s):: Tyr DASTVAAVCK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2575..2982): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDRSFDASTFEVWLWTGGDVDGYGPTETTTFALT
Nearest Stachelhaus code(s):: Val DAYWWGGTFK (91% 8Å match)
Stachelhaus code match:: 90% (moderate)

IE135_RS06240: Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (470..876): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSNAFDTSWEAFDIMLGGEYNFYGPTECTVDTLS
Nearest Stachelhaus code(s):: Orn DTEDMGFVDK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

IE135_RS06250: Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (487..773): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YRGSFDLTVTGTKVVVGGEVNAYGPTEATV----
Nearest Stachelhaus code(s):: Asp DLTKVGAVNK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

IE135_RS06270: fatty_acid

CAL_domain (42..470): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 30.1
AHBA: 14.2
NH2: 11.3
Acetyl-CoA: 3.5
shikimic_acid: -0.5

IE135_RS06290: X

AMP-binding (232..637): X

nrpys: dnmeProp, Dab

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HMKAFDISLWQSQVSVTGEVNAYGATEVSDDTMH
Nearest Stachelhaus code(s):: dnmeProp or Dab DIWQSTADDK (94% 8Å match); Asp DIWQSTADDK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
DasR	N-acetylglucosamine dependent repressor

NZ_BMSZ01000003.1 - Region 2 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 171,795 - 192,838 nt. (total: 21,044 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: dehydratase

IE135_RS06815: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase

IE135_RS06850: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4	0.36	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.35	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000678.5	0.35	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000644.3	0.34	terpene	carotenoid	Dietzia sp. CQ4
BGC0000666.5	0.34	terpene	xiamycin A	Streptomyces sp. SCSIO 02999

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4	0.36	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.35	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000678.5	0.35	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000644.3	0.34	terpene	carotenoid	Dietzia sp. CQ4
BGC0000666.5	0.34	terpene	xiamycin A	Streptomyces sp. SCSIO 02999

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

IE135_RS06850: PT_FPPS_like

Domain 1 (59 - 345): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.21 out of 23.79

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

Additional weak hits (8):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.33 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.29 out of 30.25

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.69 out of 20.97

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.87 out of 33.14

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.78 out of 30.98

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.43 out of 35.63

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.92 out of 23.43

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.67 out of 24.78

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_BMSZ01000003.1 - Region 3 - lanthipeptide-class-iii

Download region GenBank file

Download region SVG

Location: 323,555 - 345,926 nt. (total: 22,372 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase aminotransferase

IE135_RS07515: aminotransferase

smcogs: SMCOG1019: aminotransferase

IE135_RS07570: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000496.5	0.88	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.72	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000551.5	0.66	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.60	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000518.3	0.55	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.54	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002700.2	0.51	ribosomal	bacinapeptin	Bacillus nakamurai

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000496.5	0.88	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.72	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000551.5	0.66	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.60	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000518.3	0.55	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.54	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002700.2	0.51	ribosomal	bacinapeptin	Bacillus nakamurai

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for IE135_RS07555

IE135_RS07550

Leader:

MALLDLQAMDTPAEDSFGELAT

Core:

GSQVSLLVCEYSSLSVVLCTP

Core with dehydrations:

GDhaQVDhaLLVCysEYDhaDhaLDhaVVLCysDhbP

antiSMASH-DB 4.0 matches for IE135_RS07550

100.0%

NC_010572.1and 60 others:

NC_021177.1 Lanthipeptides: SFUL_RS24355_lanthipeptideNZ_AQRK01000102.1 Lanthipeptides: YUW_RS30025_lanthipeptideNZ_ARPF01000003.1 Lanthipeptides: B083_RS0107255_lanthipeptideNZ_BMRY01000001.1 Lanthipeptides: IE140_RS02070_lanthipeptideNZ_BMSP01000003.1 Lanthipeptides: IE150_RS06495_lanthipeptideNZ_BMSZ01000003.1 Lanthipeptides: IE135_RS07550_lanthipeptideNZ_BMTW01000017.1 Lanthipeptides: IE134_RS28550_lanthipeptideNZ_BMUG01000009.1 Lanthipeptides: IE264_RS25430_lanthipeptideNZ_BMVK01000002.1 Lanthipeptides: IE272_RS07115_lanthipeptideNZ_BNBJ01000002.1 Lanthipeptides: IE304_RS05195_lanthipeptideNZ_CM003601.1 Lanthipeptides: JI76_RS25200_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS10875_lanthipeptideNZ_CP011522.1 Lanthipeptides: ABE83_RS11805_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS23525_lanthipeptideNZ_CP015362.1 Lanthipeptides: A6E92_RS09975_lanthipeptideNZ_CP020563.1 Lanthipeptides: B7C62_RS24450_lanthipeptideNZ_CP020570.1 Lanthipeptides: B1H20_RS34690_lanthipeptideNZ_CP024957.1 Lanthipeptides: CVT27_RS22730_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS10225_lanthipeptideNZ_CP030930.1 Lanthipeptides: DTW94_RS22865_lanthipeptideNZ_CP061072.1 Lanthipeptides: HYC88_RS10560_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS24895_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS29435_lanthipeptideNZ_CP086102.1 Lanthipeptides: LK895_RS11660_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS24025_lanthipeptideNZ_CP096281.1 Lanthipeptides: MWG59_RS25685_lanthipeptideNZ_CP101397.1 Lanthipeptides: NLU04_RS06465_lanthipeptideNZ_CP110539.1 Lanthipeptides: OH133_RS12690_lanthipeptideNZ_CP112880.1 Lanthipeptides: N7925_RS11185_lanthipeptideNZ_CP113262.1 Lanthipeptides: OUQ49_RS22935_lanthipeptideNZ_CP117709.1 Lanthipeptides: PSQ21_RS24530_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS09925_lanthipeptideNZ_GL877172.1 Lanthipeptides: SACT1_RS12960_lanthipeptideNZ_JAAWWP010000002.1 Lanthipeptides: HFV08_RS04115_lanthipeptideNZ_JAGGOV010000004.1 Lanthipeptides: J7E92_RS02930_lanthipeptideNZ_JAHHWT010000009.1 Lanthipeptides: KM153_RS24430_lanthipeptideNZ_JALDPQ010000064.1 Lanthipeptides: MQC87_RS23965_lanthipeptideNZ_JAMFLF010000002.1 Lanthipeptides: M1212_RS07295_lanthipeptideNZ_JANRMN010000004.1 Lanthipeptides: NW249_RS08610_lanthipeptideNZ_JNLT01000003.1 Lanthipeptides: CD02_RS0108685_lanthipeptideNZ_KB890925.1 Lanthipeptides: B053_RS0113845_lanthipeptideNZ_KL573549.1 Lanthipeptides: BG84_RS0119125_lanthipeptideNZ_KQ257779.1 Lanthipeptides: IQ60_RS22540_lanthipeptideNZ_KZ195572.1 Lanthipeptides: B9W61_RS11940_lanthipeptideNZ_KZ679082.1 Lanthipeptides: C6W96_RS24050_lanthipeptideNZ_KZ819154.1 Lanthipeptides: DBP12_RS10285_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS23960_lanthipeptideNZ_KZ819182.1 Lanthipeptides: DBP21_RS24660_lanthipeptideNZ_LACR01000009.1 Lanthipeptides: YW5_RS12280_lanthipeptideNZ_LIPB01000001.1 Lanthipeptides: AMK17_RS03280_lanthipeptideNZ_LIPE01000001.1 Lanthipeptides: AMK12_RS03355_lanthipeptideNZ_LIVT01000001.1 Lanthipeptides: AMK24_RS01700_lanthipeptideNZ_LIVW01000001.1 Lanthipeptides: AMK28_RS03165_lanthipeptideNZ_LIXK01000001.1 Lanthipeptides: AMK23_RS04085_lanthipeptideNZ_LMEL01000012.1 Lanthipeptides: ASD29_RS10010_lanthipeptideNZ_LZRD01000054.1 Lanthipeptides: A3Q37_RS33745_lanthipeptideNZ_ML123117.1 Lanthipeptides: EES46_RS10300_lanthipeptideNZ_NNBN01000004.1 Lanthipeptides: CG717_RS12310_lanthipeptideNZ_VEHK01000004.1 Lanthipeptides: FS984_RS13530_lanthipeptideNZ_WWGD01000029.1 Lanthipeptides: GTY72_RS23245_lanthipeptide

Lanthipeptides: SGR_RS11800_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSVVLCTP

1

GSQVSLLVCEYSSLSVVLCTP

21

95.2%

NZ_BDHJ01000008.1and 4 others:

NZ_CP032543.1 Lanthipeptides: D6270_RS22715_lanthipeptideNZ_CP076457.1 Lanthipeptides: KME66_RS09945_lanthipeptideNZ_CP077652.1 Lanthipeptides: KRR37_RS22855_lanthipeptideNZ_WUEJ01000001.1 Lanthipeptides: GRQ63_RS04560_lanthipeptide

Lanthipeptides: BHQ08_RS03045_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSV LCTP

1

GSQVSLLVCEYSSLSVTLCTP

21

95.2%

NZ_CP010519.1and 1 other:

NZ_CP092644.1 Lanthipeptides: MID12_RS21330_lanthipeptide

Lanthipeptides: SLNWT_RS22370_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSVVLC+P

1

GSQVSLLVCEYSSLSVVLCSP

21

with 77 more sequence matches

Only the first 10 are displayed here.

95.2%

NZ_CP045178.1:

Lanthipeptides: GBW32_RS28450_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CEYSSLSVVLCTP

1

GSQVSLLICEYSSLSVVLCTP

21

95.2%

NZ_CP054926.1and 11 others:

NZ_CP068598.1 Lanthipeptides: IFE09_RS23820_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS23495_lanthipeptideNZ_CP080029.1 Lanthipeptides: KZO11_RS24935_lanthipeptideNZ_JAJUKK010000008.1 Lanthipeptides: LXH09_RS27635_lanthipeptideNZ_JOJC01000009.1 Lanthipeptides: IO23_RS0108435_lanthipeptideNZ_KB891296.1 Lanthipeptides: B061_RS0103425_lanthipeptideNZ_KZ268499.1 Lanthipeptides: CE422_RS23450_lanthipeptideNZ_KZ819159.1 Lanthipeptides: DBP19_RS22830_lanthipeptideNZ_LR881952.1 Lanthipeptides: STRPST75_RS10975_lanthipeptideNZ_LZQS01000001.1 Lanthipeptides: STIB_RS05225_lanthipeptideNZ_RCOL01000001.1 Lanthipeptides: STAN_RS24840_lanthipeptide

Lanthipeptides: HUT09_RS23550_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCE+SSLSVVLCTP

1

GSQVSLLVCEFSSLSVVLCTP

21

95.2%

NZ_CP058556.1and 5 others:

NZ_CP059898.1 Lanthipeptides: H3V39_RS22935_lanthipeptideNZ_CP070242.1 Lanthipeptides: I6J39_RS23755_lanthipeptideNZ_CP070260.1 Lanthipeptides: I6J40_RS10935_lanthipeptideNZ_JAJDST010000047.1 Lanthipeptides: LJC81_RS16960_lanthipeptideNZ_WWGL01000003.1 Lanthipeptides: GTY38_RS03410_lanthipeptide

Lanthipeptides: HXS80_RS11105_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVS+LVCEYSSLSVVLCTP

1

GSQVSVLVCEYSSLSVVLCTP

21

90.5%

NZ_CM001165.1and 4 others:

NZ_CP021118.1 Lanthipeptides: CAC01_RS28155_lanthipeptideNZ_CP049945.1 Lanthipeptides: G9U55_RS17850_lanthipeptideNZ_CP119149.1 Lanthipeptides: P0D76_RS02270_lanthipeptideNZ_RWGV01000033.1 Lanthipeptides: EJA11_RS20985_lanthipeptide

Lanthipeptides: STTU_RS29395_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CEYSSLSV LCTP

1

GSQVSLLICEYSSLSVTLCTP

21

85.7%

NC_020990.1and 26 others:

NZ_AMPN02000002.1 Lanthipeptides: SM8_RS12785_lanthipeptideNZ_AP025692.1 Lanthipeptides: MTP06_RS18190_lanthipeptideNZ_CM002273.1 Lanthipeptides: B590_RS12280_lanthipeptideNZ_CP009802.1 Lanthipeptides: SFR_RS12925_lanthipeptideNZ_CP014485.1 Lanthipeptides: Salbus254_RS12710_lanthipeptideNZ_CP016824.1 Lanthipeptides: BEN82_RS18165_lanthipeptideNZ_CP026490.1 Lanthipeptides: C3K23_RS19520_lanthipeptideNZ_CP031742.1 Lanthipeptides: D0C37_RS13445_lanthipeptideNZ_CP047147.1 Lanthipeptides: GR131_RS18520_lanthipeptideNZ_CP053539.1 Lanthipeptides: HN026_RS11800_lanthipeptideNZ_CP056773.1 Lanthipeptides: HWN34_RS12245_lanthipeptideNZ_CP063844.1 Lanthipeptides: IPZ55_RS12410_lanthipeptideNZ_CP064783.1 Lanthipeptides: IT782_RS12060_lanthipeptideNZ_CP076385.1 Lanthipeptides: KNZ81_RS12450_lanthipeptideNZ_CP079112.1 Lanthipeptides: STALF2_RS18135_lanthipeptideNZ_CP091820.1 Lanthipeptides: L2I08_RS02835_lanthipeptideNZ_CP106650.1 Lanthipeptides: B591_RS12385_lanthipeptideNZ_CP113103.1 Lanthipeptides: OSU72_RS17905_lanthipeptideNZ_JAHUVY010000001.1 Lanthipeptides: STALF3_RS17905_lanthipeptideNZ_JALLPQ010000001.1 Lanthipeptides: MWG58_RS12385_lanthipeptideNZ_KB890715.1 Lanthipeptides: B048_RS0115750_lanthipeptideNZ_KN549183.1 Lanthipeptides: D076_RS30740_lanthipeptideNZ_KZ195583.1 Lanthipeptides: B9W68_RS12440_lanthipeptideNZ_MNPQ01000004.1 Lanthipeptides: BGV78_RS11170_lanthipeptideNZ_OX371412.1 Lanthipeptides: OZE77_RS18215_lanthipeptideNZ_VOGX01000092.1 Lanthipeptides: FRZ02_RS31600_lanthipeptide

Lanthipeptides: XNR_RS11575_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQ+SLL+CEYSSLSV LCTP

1

GSQISLLICEYSSLSVTLCTP

21

85.7%

NZ_AQRJ01000051.1and 1 other:

NZ_LFBV01000002.1 Lanthipeptides: AB852_RS09920_lanthipeptide

Lanthipeptides: YW7_RS14945_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSL+VCEYSSLS +LCTP

1

GSQVSLIVCEYSSLSALLCTP

21

85.7%

NZ_CP045702.1:

Lanthipeptides: F0344_RS33200_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCE+SSLS+ LCTP

1

GSQVSLLVCEHSSLSLTLCTP

21

85.7%

NZ_ML123034.1:

Lanthipeptides: EES43_RS19795_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CE+SSLSV LCTP

1

GSQVSLLICEFSSLSVTLCTP

21

81.0%

NZ_LWLE01000019.1:

Lanthipeptides: A6A29_RS44250_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CE+SSLS+ LCTP

1

GSQVSLLICEHSSLSLTLCTP

21

61.9%

NZ_QGGR01000008.1:

Lanthipeptides: BC793_RS19230_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCT

20

GSQ SLL+C SSLSV C

2

GSQASLLLCGDSSLSVTTCN

21

MIBiG 4.0 matches for IE135_RS07550

95.5%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSVVLCTP

2

GSQVSLLVCEYSSLSVVLCTP

22

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.51 out of 25.31

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 17.94 out of 23.79

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (5):

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.84 out of 29.38

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.41 out of 30.97

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.69 out of 29.65

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

IE135_RS07550 - Class III

Cleavage pHMM score: 31.80

RODEO score: 0

Monoisotopic mass: 2075.1 Da

Molecular weight: 2076.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2094.4 Da N = 1; 2112.4 Da N = 2; 2130.5 Da N = 3; 2148.5 Da N = 4

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CatR	H2O2-responsive repressor
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMSZ01000003.1 - Region 4 - NRPS-like,T1PKS,T2PKS

Download region GenBank file

Download region SVG

Location: 394,238 - 499,207 nt. (total: 104,970 nt) Show pHMM detection rules used

T2PKS: (t2ks and t2clf)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

IE135_RS07870: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

IE135_RS07935: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

IE135_RS07950: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

IE135_RS07970: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

IE135_RS08090: dihydropteridine reductase

smcogs: SMCOG1159: dihydropteridine reductase

IE135_RS08150: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

IE135_RS08215: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Transferases: PPTase acylase aminotransferase

IE135_RS07955: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

IE135_RS07990: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

IE135_RS08135: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: esterase hydrolase protease

IE135_RS07835: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

IE135_RS07915: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

IE135_RS08145: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase lyase

IE135_RS07965: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

IE135_RS08165: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase

IE135_RS07840: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

IE135_RS07875: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

IE135_RS07980: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

IE135_RS07985: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IE135_RS08130: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

IE135_RS08155: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

IE135_RS08075: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.83	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000231.5	0.77	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.70	NRPS	peramine	Epichloe festucae
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.68	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000195.5	0.80	PKS	alnumycin A, alnumycin B, alnumycin C, alnumycin P, prealnumycin, thalnumycin A, thalnumycin B, K1115A, 1,6-dihydro-8-propylanthraquinone	Streptomyces sp. CM020
BGC0000231.5	0.75	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.68	NRPS	peramine	Epichloe festucae
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.97 out of 27.04

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.83 out of 20.47

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.29 out of 23.79

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.88 out of 36.53

Confidence: medium

Additional weak hits (20):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.58 out of 25.88

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.51 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.22 out of 36.54

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.58 out of 30.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.70 out of 26.33

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.26 out of 18.57

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.18 out of 31.73

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.49 out of 30.97

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.77 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.44 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.67 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.61 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.79 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.36 out of 27.78

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.32 out of 30.98

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.12 out of 36.53

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.92 out of 28.19

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.83 out of 30.11

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.11 out of 31.73

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Type II PKS

TFBS Finder

Predicted core structure(s)

For candidate cluster 6, location 394237 - 499207:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 394237 - 466789:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 444631 - 487868:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 456606 - 499207:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS07990: mal

PKS_AT (3..301): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 80.5
Methylmalonyl-CoA: 37.1
Methoxymalonyl-CoA: 31.5
Propionyl-CoA: 23.1
inactive: 18.6
Benzoyl-CoA: 12.9
fatty_acid: 9.7
Ethylmalonyl-CoA: 3.3
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

IE135_RS08130: mal

PKS_AT (556..838): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 116.4
inactive: 70.7
Methylmalonyl-CoA: 57.3
Methoxymalonyl-CoA: 53.5
Isobutyryl-CoA: 36.1
Propionyl-CoA: 32.3
CHC-CoA: 31.7
Ethylmalonyl-CoA: 30.8
fatty_acid: 22.1
Benzoyl-CoA: 21.4
2-Methylbutyryl-CoA: 14.7
Acetyl-CoA: 12.5
trans-1,2-CPDA: 11.9
3-Methylbutyryl-CoA: 9.2

IE135_RS08155: aThr

Search NORINE for peptide: strict or relaxed

AMP-binding (295..679): aThr

nrpys: aThr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LAVHFDFSVWEGSQVLGGEVNMYGITETTVHVTA
Nearest Stachelhaus code(s):: aThr DFWSVGMVHK (94% 8Å match); Thr DFWSVGMVHK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 394237 to 466789
Starter unit(s):: butyryl-CoA (Score: 754.0; E-value: 0)
Malonyl elongations:: 7 (Score: 697.5; E-value: 1e-212)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: butyryl-CoA_7: 353 Da

IE135_RS07875: KSIII (Score: 402.3; E-value: 3.7e-123); KSIII ACI88883.1_Alnumycin_butyryl-CoA (Score: 531.0; E-value: 0.0)
IE135_RS07935: KR (Score: 173.0; E-value: 2.1e-53)
IE135_RS07950: OXY (Score: 16.9; E-value: 6.2e-06)
IE135_RS07960: CYC C5-C14 (Score: 469.7; E-value: 7.9e-144)
IE135_RS07965: CYC C7-C12 (Score: 358.4; E-value: 6.1e-110)
IE135_RS07970: KR C9 (Score: 455.2; E-value: 1.4e-139)
IE135_RS07975: ACP (Score: 102.9; E-value: 1.6e-32)
IE135_RS07980: CLF 7 (Score: 697.5; E-value: 1e-212)
IE135_RS07985: KS (Score: 779.8; E-value: 1.4e-237)
IE135_RS07990: AT (Score: 381.8; E-value: 6.5e-117); AT AAC18106.1_Frenolicin_butyryl-CoA (Score: 223.0; E-value: 8.61e-74)
IE135_RS07995: ACP (Score: 74.9; E-value: 9e-24)

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMSZ01000004.1 - Region 1 - lanthipeptide-class-ii,lanthipeptide-class-iii

Download region GenBank file

Download region SVG

Location: 11,181 - 42,382 nt. (total: 31,202 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

IE135_RS08570: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Hydrolases: protease

IE135_RS08640: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

IE135_RS08580: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.37	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.37	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000525.5	0.36	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000519.4	0.36	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001226.4	0.36	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000501.3	0.35	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000518.3	0.35	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000513.3	0.32	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000517.4	0.29	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000546.3	0.28	ribosomal	SAL-2242	Streptomyces albidoflavus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.50	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.50	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000519.4	0.49	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001226.4	0.49	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000501.3	0.49	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000518.3	0.49	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000513.3	0.47	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000517.4	0.44	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001407.5	0.43	ribosomal	bicereucin	Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for IE135_RS08580

IE135_RS08610

Leader:

MSENTKPAGDETNETPEVEAHSVLDLQETSVQGG

IE135_RS08610

Leader:

MSENTKPAGDETNETPEVEAHSVLDLQETSVQGG

Shared core:

DTTDGNCISVLSVVEQQR

Core with dehydrations:

DDhbDhbDGNCysIDhaVLDhaVVEQQR

antiSMASH-DB 4.0 matches for IE135_RS08610

100.0%

NZ_BMRY01000010.1and 58 others:

NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide

Lanthipeptides: IE140_RS27680_lanthipeptide

1

DTTDGNCISVLSVVEQQR

18

DTTDGNCISVLSVVEQQR

1

DTTDGNCISVLSVVEQQR

18

94.4%

NZ_BNBJ01000007.1and 21 others:

NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide

Lanthipeptides: IE304_RS13825_lanthipeptide

1

DTTDGNCISVLSVVEQQR

18

DTTDGNCISVLSVVE QR

1

DTTDGNCISVLSVVESQR

18

78.9%

NZ_CP117709.1:

Lanthipeptides: PSQ21_RS10520_lanthipeptide

1

DTTDGNCISVLSVVEQQ

17

D TDGNCISVLSVVE Q

1

DQTDGNCISVLSVVETQ

17

with 13 more sequence matches

Only the first 10 are displayed here.

72.2%

NZ_LZRD01000043.1:

Lanthipeptides: A3Q37_RS37410_lanthipeptide

5

GNCISVLSVVEQQR

18

GNCISVLSVVE QR

1

GNCISVLSVVESQR

14

61.1%

NZ_BNBJ01000007.1and 7 others:

NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide

Lanthipeptides: IE304_RS13830_lanthipeptide

5

GNCISVLSVVEQ

16

GNCISVLSVVE

2

GNCISVLSVVEN

13

57.9%

NZ_LZRD01000043.1:

Lanthipeptides: A3Q37_RS37415_lanthipeptide

2

TTDGNCISVLSVVEQ

16

GNCISVLSVVE

5

APPGNCISVLSVVEN

19

50.0%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide

Lanthipeptides: ASD51_RS37395_lanthipeptide

7

CISVLSVVE

15

CISVLSVVE

1

CISVLSVVE

9

38.9%

NZ_CP119145.1:

Lanthipeptides: PZB75_RS01650_lanthipeptide

7

CISVLSVVEQQR

18

C+SV+SVV +R

1

CVSVISVVLSER

12

33.3%

NZ_ML142907.1and 1 other:

NZ_ML142907.1 Lanthipeptides: DN53_RS02460_lanthipeptide

Lanthipeptides: DN53_RS02460_lanthipeptide

1

DTTDGNCISVLSVV

14

DTT+G+C S S+V

7

DTTNGDCTSGTSIV

20

23.5%

NC_021177.1and 9 others:

NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide

Lanthipeptides: SFUL_RS36595_lanthipeptide

5

GNCISVLSVV

14

G+C+SVLSVV

22

GSCVSVLSVV

31

22.2%

NZ_CP058552.1:

Lanthipeptides: HW560_RS06640_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+S ++

7

TDGNCVSTITA

17

20.0%

NZ_BDHJ01000009.1and 1 other:

NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide

Lanthipeptides: BHQ08_RS34920_lanthipeptide

5

GNCISVLSVV

14

GNC+S +S+V

19

GNCVSTVSLV

28

19.2%

NZ_BMLN01000009.1:

Lanthipeptides: IEX28_RS15335_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+ ++

7

TDGNCLKSITA

17

allorf_013533_013610

Leader:

MARTECARHGIRAA

Core:

SDNRMPCTCHE

Core with dehydrations:

DhaDNRMPCysDhbCysHE

antiSMASH-DB 4.0 matches for allorf_013533_013610

100.0%

NZ_BMSZ01000004.1and 2 others:

NZ_CP021707.1 Lanthipeptides: allorf_2310440_2310517_lanthipeptideNZ_DS999644.1 Lanthipeptides: allorf_2311996_2312073_lanthipeptide

Lanthipeptides: allorf_013533_013610_lanthipeptide

1

SDNRMPCTCHE

11

SDNRMPCTCHE

1

SDNRMPCTCHE

11

90.9%

NZ_CP013738.1and 3 others:

NZ_CP029361.1 Lanthipeptides: allorf_5022723_5022824_lanthipeptideNZ_CP090837.1 Lanthipeptides: allorf_2596303_2596404_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: allorf_0352626_0352703_lanthipeptide

Lanthipeptides: allorf_2654924_2655001_lanthipeptide

1

SDNRMPCTCHE

11

SD+RMPCTCHE

1

SDHRMPCTCHE

11

50.0%

NZ_KZ819182.1and 1 other:

NZ_WWGD01000003.1 Lanthipeptides: allorf_367697_367795_lanthipeptide

Lanthipeptides: allorf_2568935_2569033_lanthipeptide

1

SDNRMPCTCHE

11

+DNRMPCTCHE

10

TDNRMPCTCHE

20

with 2 more sequence matches

27.3%

NZ_CP020040.1:

Lanthipeptides: allorf_275398_275505_lanthipeptide

1

SDNRMPCTCHE

11

+DN +P TC E

11

ADNVLPFTCCE

21

9.4%

NZ_CP029190.1:

Lanthipeptides: allorf_1630240_1630437_lanthipeptide

2

DNRMPCTC

9

NR PC C

34

GNRWPCMC

41

Lanthipeptide(s) for IE135_RS08600

IE135_RS08610

Leader:

MSENTKPAGDETNETPEVEAHSVLDLQETSVQGG

IE135_RS08610

Leader:

MSENTKPAGDETNETPEVEAHSVLDLQETSVQGG

Shared core:

DTTDGNCISVLSVVEQQR

Core with dehydrations:

DDhbDhbDGNCysIDhaVLDhaVVEQQR

antiSMASH-DB 4.0 matches for IE135_RS08610

100.0%

NZ_BMRY01000010.1and 58 others:

NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide

Lanthipeptides: IE140_RS27680_lanthipeptide

1

DTTDGNCISVLSVVEQQR

18

DTTDGNCISVLSVVEQQR

1

DTTDGNCISVLSVVEQQR

18

94.4%

NZ_BNBJ01000007.1and 21 others:

NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide

Lanthipeptides: IE304_RS13825_lanthipeptide

1

DTTDGNCISVLSVVEQQR

18

DTTDGNCISVLSVVE QR

1

DTTDGNCISVLSVVESQR

18

78.9%

NZ_CP117709.1:

Lanthipeptides: PSQ21_RS10520_lanthipeptide

1

DTTDGNCISVLSVVEQQ

17

D TDGNCISVLSVVE Q

1

DQTDGNCISVLSVVETQ

17

with 13 more sequence matches

Only the first 10 are displayed here.

72.2%

NZ_LZRD01000043.1:

Lanthipeptides: A3Q37_RS37410_lanthipeptide

5

GNCISVLSVVEQQR

18

GNCISVLSVVE QR

1

GNCISVLSVVESQR

14

61.1%

NZ_BNBJ01000007.1and 7 others:

NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide

Lanthipeptides: IE304_RS13830_lanthipeptide

5

GNCISVLSVVEQ

16

GNCISVLSVVE

2

GNCISVLSVVEN

13

57.9%

NZ_LZRD01000043.1:

Lanthipeptides: A3Q37_RS37415_lanthipeptide

2

TTDGNCISVLSVVEQ

16

GNCISVLSVVE

5

APPGNCISVLSVVEN

19

50.0%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide

Lanthipeptides: ASD51_RS37395_lanthipeptide

7

CISVLSVVE

15

CISVLSVVE

1

CISVLSVVE

9

38.9%

NZ_CP119145.1:

Lanthipeptides: PZB75_RS01650_lanthipeptide

7

CISVLSVVEQQR

18

C+SV+SVV +R

1

CVSVISVVLSER

12

33.3%

NZ_ML142907.1and 1 other:

NZ_ML142907.1 Lanthipeptides: DN53_RS02460_lanthipeptide

Lanthipeptides: DN53_RS02460_lanthipeptide

1

DTTDGNCISVLSVV

14

DTT+G+C S S+V

7

DTTNGDCTSGTSIV

20

23.5%

NC_021177.1and 9 others:

NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide

Lanthipeptides: SFUL_RS36595_lanthipeptide

5

GNCISVLSVV

14

G+C+SVLSVV

22

GSCVSVLSVV

31

22.2%

NZ_CP058552.1:

Lanthipeptides: HW560_RS06640_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+S ++

7

TDGNCVSTITA

17

20.0%

NZ_BDHJ01000009.1and 1 other:

NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide

Lanthipeptides: BHQ08_RS34920_lanthipeptide

5

GNCISVLSVV

14

GNC+S +S+V

19

GNCVSTVSLV

28

19.2%

NZ_BMLN01000009.1:

Lanthipeptides: IEX28_RS15335_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+ ++

7

TDGNCLKSITA

17

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 27.04

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

Additional weak hits (8):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.70 out of 21.55

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.03 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.04 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.63 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.10 out of 30.25

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.75 out of 39.62

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.83 out of 20.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.80 out of 28.19

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

IE135_RS08610 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1890.9 Da

Molecular weight: 1892.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1910.1 Da N = 1; 1928.1 Da N = 2; 1946.1 Da N = 3

allorf_013533_013610 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 1255.5 Da

Molecular weight: 1256.4 Da

Number of bridges: 2

IE135_RS08610 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1890.9 Da

Molecular weight: 1892.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1910.1 Da N = 1; 1928.1 Da N = 2; 1946.1 Da N = 3

IE135_RS08610 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1890.9 Da

Molecular weight: 1892.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1910.1 Da N = 1; 1928.1 Da N = 2; 1946.1 Da N = 3

IE135_RS08610 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1890.9 Da

Molecular weight: 1892.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1910.1 Da N = 1; 1928.1 Da N = 2; 1946.1 Da N = 3

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
DasR	N-acetylglucosamine dependent repressor

NZ_BMSZ01000004.1 - Region 2 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 82,505 - 112,283 nt. (total: 29,779 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

IE135_RS08850: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

IE135_RS08885: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

IE135_RS08945: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: carboxylase transferase

IE135_RS08835: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

IE135_RS08840: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: hydrolase

IE135_RS08910: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: decarboxylase

IE135_RS08880: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: synthase

IE135_RS08845: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000941.3	0.83	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.73	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000940.5	0.68	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.67	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0002464.3	0.61	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002284.3	0.59	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002690.2	0.59	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000941.3	0.83	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.73	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000940.5	0.68	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.67	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0002464.3	0.61	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002284.3	0.59	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002690.2	0.59	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 33.53 out of 36.53

Confidence: strong

Additional weak hits (9):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.13 out of 30.97

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.25 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.29 out of 36.54

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.26 out of 27.78

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.23 out of 23.43

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.23 out of 36.54

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.87 out of 20.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.73 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor

NZ_BMSZ01000005.1 - Region 1 - oligosaccharide

Download region GenBank file

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Location: 2,667 - 33,645 nt. (total: 30,979 nt) Show pHMM detection rules used

Region on contig edge.

oligosaccharide: (repeatable(3, [DUF1205, Glyco_transf_28, Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT, 150))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

IE135_RS10165: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IE135_RS10240: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IE135_RS10250: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: acylase aminotransferase glycosyltransferase methyltransferase transferase

IE135_RS10185: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

IE135_RS10190: aminotransferase

smcogs: SMCOG1019: aminotransferase

IE135_RS10205: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

IE135_RS10210: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

IE135_RS10225: methyltransferase

smcogs: SMCOG1248: methyltransferase

IE135_RS10230: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

IE135_RS10245: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

IE135_RS10255: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: dehalogenase

IE135_RS10200: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Lyases: dehydratase

IE135_RS10215: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase

IE135_RS10180: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS34020: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS34025: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002164.2	0.60	NRPS	peramine	Epichloe festucae
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0000278.3	0.60	PKS	urdamycin	Streptomyces fradiae
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001268.4	0.59	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000307.4	0.59	NRPS	AbT1	Aureobasidium pullulans
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002164.2	0.60	NRPS	peramine	Epichloe festucae
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0000278.3	0.60	PKS	urdamycin	Streptomyces fradiae
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001268.4	0.59	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000307.4	0.59	NRPS	AbT1	Aureobasidium pullulans
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (3):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.86 out of 30.22

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.94 out of 19.26

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.23 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

NZ_BMSZ01000005.1 - Region 2 - hydrogen-cyanide

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Location: 97,649 - 110,579 nt. (total: 12,931 nt) Show pHMM detection rules used

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene overview

Tailoring

MIBiG comparison

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SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

IE135_RS10555: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

IE135_RS10565: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Hydrolases: peptidase

IE135_RS10585: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0002436.2	0.37	other (other)	coformycin	Streptomyces citricolor
BGC0002285.2	0.30	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001007.5	0.29	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin b	Salinispora arenicola CNS-205
BGC0001006.5	0.27	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin B	Salinispora tropica CNB-440
BGC0000595.3	0.26	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000135.5	0.21	PKS	reveromycin A	Streptomyces sp. SN-593

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0002436.2	0.37	other (other)	coformycin	Streptomyces citricolor
BGC0002285.2	0.30	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001007.5	0.29	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin b	Salinispora arenicola CNS-205
BGC0001006.5	0.27	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin B	Salinispora tropica CNB-440
BGC0000595.3	0.26	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000135.5	0.21	PKS	reveromycin A	Streptomyces sp. SN-593

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 24.47 out of 29.72

Confidence: medium

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 22.40

Confidence: strong

Additional weak hits (7):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.87 out of 20.01

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.09 out of 30.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.36 out of 29.65

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.93 out of 39.62

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.35 out of 33.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 20.42 out of 22.40

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
HypR	L-hydroxyproline utilization repressor
NtrC	Nitrogen regulatory protein C

NZ_BMSZ01000005.1 - Region 3 - RiPP-like

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Location: 296,276 - 307,622 nt. (total: 11,347 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000496.5	0.33	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000565.5	0.31	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000306.5	0.28	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0001789.3	0.28	ribosomal	suicin 90-1330	Streptococcus suis
BGC0002126.3	0.27	NRPS	hypeptin	Lysobacter sp. K5869
BGC0002303.3	0.27	ribosomal	pristinin A3	Streptomyces pristinaespiralis
BGC0002387.2	0.27	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0000461.5	0.27	NRPS	WAP-8294A2	Lysobacter enzymogenes
BGC0002115.3	0.26	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001377.5	0.26	PKS	uncialamycin	Streptomyces uncialis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000496.5	0.33	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000565.5	0.31	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000306.5	0.28	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0001789.3	0.28	ribosomal	suicin 90-1330	Streptococcus suis
BGC0002126.3	0.27	NRPS	hypeptin	Lysobacter sp. K5869
BGC0002303.3	0.27	ribosomal	pristinin A3	Streptomyces pristinaespiralis
BGC0002387.2	0.27	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0000461.5	0.27	NRPS	WAP-8294A2	Lysobacter enzymogenes
BGC0002115.3	0.26	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001377.5	0.26	PKS	uncialamycin	Streptomyces uncialis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.30 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_BMSZ01000006.1 - Region 1 - butyrolactone,ectoine

Download region GenBank file

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Location: 111,919 - 127,128 nt. (total: 15,210 nt) Show pHMM detection rules used

ectoine: ectoine_synt
butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase synthase

IE135_RS12230: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

IE135_RS12270: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

IE135_RS12285: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Transferases: PPTase

IE135_RS12250: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: synthase

IE135_RS12285: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Ligases: ligase

IE135_RS12215: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.97	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.74	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0001778.5	0.50	other (other)	showdomycin	Streptomyces showdoensis
BGC0000850.5	0.40	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0000131.5	0.30	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002578.2	0.30	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000706.3	0.29	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001723.5	0.26	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.25	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001464.3	0.25	other (other)	tetrabromopyrrole	Pseudoalteromonas sp. PS5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.78	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.77	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001641.4	0.58	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000850.5	0.58	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0001778.5	0.57	other (other)	showdomycin	Streptomyces showdoensis
BGC0002578.2	0.48	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.47	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000131.5	0.46	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001723.5	0.46	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (9):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.74 out of 20.01

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.22 out of 20.01

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.04 out of 18.57

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.49 out of 28.14

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.92 out of 30.22

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.22 out of 20.01

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.36 out of 20.01

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

NZ_BMSZ01000006.1 - Region 2 - lanthipeptide-class-ii

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Location: 227,755 - 253,962 nt. (total: 26,208 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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KnownClusterBlast

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Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

IE135_RS12745: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Lyases: cyclase hydratase

IE135_RS12770: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

IE135_RS12785: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

IE135_RS12795: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5	0.55	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3	0.53	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5	0.55	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3	0.53	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for IE135_RS12785

IE135_RS12780

Leader:

MANPNVGILEEIDDQNLDAVSAA

Core:

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

Core with dehydrations:

GQGWGDhbIVDhaDhaLDhaCysYGADhaYVLGNNGNFCysDhbADhbAECysQNNCysK

antiSMASH-DB 4.0 matches for IE135_RS12780

100.0%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

94.7%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT++SSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

89.5%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT +SSLSCYGASYVLGNNGNFCTATAECQ+NC+

1

GQGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSNCQ

38

with 112 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

2

QGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

QG GT V++LSCYG S+ LGN+GNFCTAT ECQ+NCK

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

66.7%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

55.3%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++L+C GASY LG+ G CTAT EC NNC+

3

WGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

52.6%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

3

GW-GTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GW G S +SC S+ LGN+G CT TAECQ CK

1

GWTGVAKSIVSCSLISFALGNDGWICTWTAECQATCK

37

50.0%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

2

QGWG-TIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

+ W TI++SL+C ASY+LGN G+ CT T ECQ C

3

ERWAETILTSLACAAASYILGNPGHVCTLTVECQKKC

39

50.0%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++LSC AS ++G+ G CT T ECQNNC+

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

3

GWGTIVSSL-SCYGASYVLGNNGNFCTATAECQNNCK

38

GW + S+ SC S LGN+G CT TAECQ C+

1

GWTGVAKSITSCSLLSIGLGNDGWVCTWTAECQATCR

37

47.4%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

5

GTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GTI +LS Y +GN+G CT T ECQNNC

5

GTISITLSVY-----MGNDGKVCTWTVECQNNC

32

47.4%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide

Lanthipeptides: GHI93_RS00065_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

G W + SS+ + LGNNG CT T ECQ NCK

1

GWTWNLVFSSV----VTLALGNNGYVCTWTHECQANCK

34

44.7%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

6

TIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

TI +++ AS+ LGNNG+ CT T ECQ NC+

1

TIFETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

MIBiG 4.0 matches for IE135_RS12780

36.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

14

YGASYVLGNNGNFCTATAECQNNC

37

+ S LGNNG +CT T ECQ NC

6

FSLSNALGNNGGWCTLTKECQPNC

29

31.6%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

14

YGASYVLGNNGNFCTATAECQNNC

37

Y S LGN G +CT T EC +C

4

YNISCRLGNKGAYCTLTVECMPSC

27

17.9%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTATAECQNNC

37

CT + ECQ NC

28

CTLSKECQPNC

38

IE135_RS12790

Leader:

MGDIAMNDATGYVSADELVELADA

Core:

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

Core with dehydrations:

PDDhaLAAGIDhbPDhbIVPADhbAVDhbDhbVIVGADhaAAMQGGCysPDhbDhaGCysDhbKRCys

antiSMASH-DB 4.0 matches for IE135_RS12790

100.0%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

95.2%

NZ_BMRY01000003.1and 9 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide

Lanthipeptides: IE140_RS12360_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PDSLAAG TPTI+PATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

92.9%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAG TPTI+PATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

with 82 more sequence matches

Only the first 10 are displayed here.

83.3%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAGITPTI+PAT V IVGASAA+QGGCPTSGCTKRC

1

PESLAAGITPTILPATGV---IVGASAALQGGCPTSGCTKRC

39

42.9%

NZ_CKMQ01000043.1and 8 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide

Lanthipeptides: AE832_RS09950_lanthipeptide

8

ITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

ITPTI+PAT + G CPTSGCTK C

1

ITPTIIPATISFVGVTFTVTLNAGACPTSGCTKSC

35

42.9%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

9

TPTIVPATAV----TTVIVGASAAMQGGCPTSGCTKRC

42

TPT+V + TT V SAA CPTS CTK+C

2

TPTVVLTATIGLTGTTFTVTLSAA---SCPTSACTKQC

36

40.5%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

2

DSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

+S AG TP IV A + T + Q CPTS C+K C

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

40.5%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

8

ITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

ITPTIV TAVT I CPT+ CT+ C

1

ITPTIV-ITAVTGYI------STNTCPTTSCTRAC

28

40.5%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

8

ITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

ITPTI+ AT + G CPTSGCTK C

1

ITPTIIAATISFAGVTFTVTLNAGACPTSGCTKSC

35

38.1%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P S A TP I T V A+ CPTS CT+ C

3

PASPATPYTPAIGKGVIAVTAFVSANT-----CPTSACTRAC

39

38.1%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

9

TPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTIV TA+T I S CPT+ CT+ C

2

TPTIV-ITAITGYISANS------CPTTACTRAC

28

35.7%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

14

PATAVTTVIVGASAAMQGG-CPTSGCTKRC

42

PAT T VIV SA + CPT+ CT+ C

3

PATPATPVIVAVSAYVSDKTCPTTACTRAC

32

35.7%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

8

ITPTIVPATAVTTVIVGASAAMQGG-CPTSGCTKRC

42

+ P PAT I+GA+ A+ CPT+ CT RC

3

VNPETTPATPT---IIGATIAVTASLCPTTKCTSRC

35

MIBiG 4.0 matches for IE135_RS12790

31.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

VIVGASAAMQGGCPTSGCTKRC

42

V VG SAA CPT+ CT RC

19

VAVGVSAAF---CPTTKCTSRC

37

16.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

14

PATAVTTVIVGASAAMQGGC

33

P T +V SA GC

4

PCTIYASVSASISATASWGC

23

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

33

CPTSGCTKRC

42

CPT+ CT +C

17

CPTTKCTSKC

26

allorf_229072_229176

Leader:

MPTLYRRRGRSRDVHAA

Core:

RACWPRVDTPATDRTST

Core with dehydrations:

RACysWPRVDDhbPADhbDRDhbDhaDhb

antiSMASH-DB 4.0 matches for allorf_229072_229176

100.0%

NZ_BMRY01000003.1and 2 others:

NZ_BMSZ01000006.1 Lanthipeptides: allorf_229072_229176_lanthipeptideNZ_CP021707.1 Lanthipeptides: allorf_3969694_3969798_lanthipeptide

Lanthipeptides: allorf_465546_465650_lanthipeptide

1

RACWPRVDTPATDRTST

17

RACWPRVDTPATDRTST

1

RACWPRVDTPATDRTST

17

35.3%

NZ_CP048405.1:

Lanthipeptides: allorf_5239945_5240040_lanthipeptide

2

ACWPRVDTPAT

12

ACW R D A+

4

ACWIRADGLAS

14

23.5%

NZ_CP011505.1and 1 other:

NZ_DF978419.1 Lanthipeptides: allorf_0451182_0451304_lanthipeptide

Lanthipeptides: allorf_0567657_0567779_lanthipeptide

3

CWPRV

7

CWPR+

7

CWPRI

11

allorf_235964_236128

Leader:

MKSRRRRPYGPEGCRNVPAGLDSIRCRNVPAG

Core:

FTAPVLPSALPPSPRPWNRSCV

Core with dehydrations:

FDhbAPVLPDhaALPPDhaPRPWNRDhaCysV

antiSMASH-DB 4.0 matches for allorf_235964_236128

100.0%

NZ_BMSZ01000006.1and 1 other:

NZ_BMSZ01000006.1 Lanthipeptides: allorf_235964_236128_lanthipeptide

Lanthipeptides: allorf_235964_236128_lanthipeptide

1

FTAPVLPSALPPSPRPWNRSCV

22

FTAPVLPSALPPSPRPWNRSCV

1

FTAPVLPSALPPSPRPWNRSCV

22

95.5%

NZ_CP021707.1:

Lanthipeptides: allorf_3962821_3962985_lanthipeptide

1

FTAPVLPSALPPSPRPWNRSCV

22

F APVLPSALPPSPRPWNRSCV

1

FAAPVLPSALPPSPRPWNRSCV

22

29.2%

NZ_JALDPQ010000054.1and 1 other:

NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114966_115073_lanthipeptide

Lanthipeptides: allorf_114966_115073_lanthipeptide

13

SPRPWNRSCV

22

+P PWN SCV

15

TPPPWNWSCV

24

with 3 more sequence matches

25.0%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: allorf_3265908_3266039_lanthipeptideNZ_CP051884.1 Lanthipeptides: allorf_3265908_3266039_lanthipeptide

Lanthipeptides: allorf_3265908_3266039_lanthipeptide

5

VLPSALPPSPRPWNR

19

V +A PRPW R

9

VTRAAQTGDPRPWGR

23

22.7%

NZ_BMRY01000003.1and 5 others:

NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide

Lanthipeptides: allorf_458543_458737_lanthipeptide

12

PSPRPWNRSCV

22

PSPRPWN SCV

34

PSPRPWNWSCV

44

13.0%

NZ_BMUQ01000012.1:

Lanthipeptides: allorf_026353_026553_lanthipeptide

5

VLPSALPPSPRPWNRSC

21

P PP+ R W R+C

25

TTPLGAPPARRAWGRAC

41

Lanthipeptide(s) for IE135_RS12795

IE135_RS12780

Leader:

MANPNVGILEEIDDQNLDAVSAA

Core:

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

Core with dehydrations:

GQGWGDhbIVDhaDhaLDhaCysYGADhaYVLGNNGNFCysDhbADhbAECysQNNCysK

antiSMASH-DB 4.0 matches for IE135_RS12780

100.0%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

94.7%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT++SSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

89.5%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT +SSLSCYGASYVLGNNGNFCTATAECQ+NC+

1

GQGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSNCQ

38

with 112 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

2

QGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

QG GT V++LSCYG S+ LGN+GNFCTAT ECQ+NCK

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

66.7%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

55.3%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++L+C GASY LG+ G CTAT EC NNC+

3

WGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

52.6%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

3

GW-GTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GW G S +SC S+ LGN+G CT TAECQ CK

1

GWTGVAKSIVSCSLISFALGNDGWICTWTAECQATCK

37

50.0%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

2

QGWG-TIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

+ W TI++SL+C ASY+LGN G+ CT T ECQ C

3

ERWAETILTSLACAAASYILGNPGHVCTLTVECQKKC

39

50.0%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++LSC AS ++G+ G CT T ECQNNC+

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

3

GWGTIVSSL-SCYGASYVLGNNGNFCTATAECQNNCK

38

GW + S+ SC S LGN+G CT TAECQ C+

1

GWTGVAKSITSCSLLSIGLGNDGWVCTWTAECQATCR

37

47.4%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

5

GTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GTI +LS Y +GN+G CT T ECQNNC

5

GTISITLSVY-----MGNDGKVCTWTVECQNNC

32

47.4%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide

Lanthipeptides: GHI93_RS00065_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

G W + SS+ + LGNNG CT T ECQ NCK

1

GWTWNLVFSSV----VTLALGNNGYVCTWTHECQANCK

34

44.7%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

6

TIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

TI +++ AS+ LGNNG+ CT T ECQ NC+

1

TIFETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

MIBiG 4.0 matches for IE135_RS12780

36.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

14

YGASYVLGNNGNFCTATAECQNNC

37

+ S LGNNG +CT T ECQ NC

6

FSLSNALGNNGGWCTLTKECQPNC

29

31.6%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

14

YGASYVLGNNGNFCTATAECQNNC

37

Y S LGN G +CT T EC +C

4

YNISCRLGNKGAYCTLTVECMPSC

27

17.9%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTATAECQNNC

37

CT + ECQ NC

28

CTLSKECQPNC

38

IE135_RS12790

Leader:

MGDIAMNDATGYVSADELVELADA

Core:

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

Core with dehydrations:

PDDhaLAAGIDhbPDhbIVPADhbAVDhbDhbVIVGADhaAAMQGGCysPDhbDhaGCysDhbKRCys

antiSMASH-DB 4.0 matches for IE135_RS12790

100.0%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

95.2%

NZ_BMRY01000003.1and 9 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide

Lanthipeptides: IE140_RS12360_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PDSLAAG TPTI+PATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

92.9%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAG TPTI+PATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

with 82 more sequence matches

Only the first 10 are displayed here.

83.3%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAGITPTI+PAT V IVGASAA+QGGCPTSGCTKRC

1

PESLAAGITPTILPATGV---IVGASAALQGGCPTSGCTKRC

39

42.9%

NZ_CKMQ01000043.1and 8 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide

Lanthipeptides: AE832_RS09950_lanthipeptide

8

ITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

ITPTI+PAT + G CPTSGCTK C

1

ITPTIIPATISFVGVTFTVTLNAGACPTSGCTKSC

35

42.9%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

9

TPTIVPATAV----TTVIVGASAAMQGGCPTSGCTKRC

42

TPT+V + TT V SAA CPTS CTK+C

2

TPTVVLTATIGLTGTTFTVTLSAA---SCPTSACTKQC

36

40.5%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

2

DSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

+S AG TP IV A + T + Q CPTS C+K C

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

40.5%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

8

ITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

ITPTIV TAVT I CPT+ CT+ C

1

ITPTIV-ITAVTGYI------STNTCPTTSCTRAC

28

40.5%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

8

ITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

ITPTI+ AT + G CPTSGCTK C

1

ITPTIIAATISFAGVTFTVTLNAGACPTSGCTKSC

35

38.1%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P S A TP I T V A+ CPTS CT+ C

3

PASPATPYTPAIGKGVIAVTAFVSANT-----CPTSACTRAC

39

38.1%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

9

TPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTIV TA+T I S CPT+ CT+ C

2

TPTIV-ITAITGYISANS------CPTTACTRAC

28

35.7%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

14

PATAVTTVIVGASAAMQGG-CPTSGCTKRC

42

PAT T VIV SA + CPT+ CT+ C

3

PATPATPVIVAVSAYVSDKTCPTTACTRAC

32

35.7%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

8

ITPTIVPATAVTTVIVGASAAMQGG-CPTSGCTKRC

42

+ P PAT I+GA+ A+ CPT+ CT RC

3

VNPETTPATPT---IIGATIAVTASLCPTTKCTSRC

35

MIBiG 4.0 matches for IE135_RS12790

31.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

VIVGASAAMQGGCPTSGCTKRC

42

V VG SAA CPT+ CT RC

19

VAVGVSAAF---CPTTKCTSRC

37

16.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

14

PATAVTTVIVGASAAMQGGC

33

P T +V SA GC

4

PCTIYASVSASISATASWGC

23

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

33

CPTSGCTKRC

42

CPT+ CT +C

17

CPTTKCTSKC

26

allorf_235964_236128

Leader:

MKSRRRRPYGPEGCRNVPAGLDSIRCRNVPAG

Core:

FTAPVLPSALPPSPRPWNRSCV

Core with dehydrations:

FDhbAPVLPDhaALPPDhaPRPWNRDhaCysV

antiSMASH-DB 4.0 matches for allorf_235964_236128

100.0%

NZ_BMSZ01000006.1and 1 other:

NZ_BMSZ01000006.1 Lanthipeptides: allorf_235964_236128_lanthipeptide

Lanthipeptides: allorf_235964_236128_lanthipeptide

1

FTAPVLPSALPPSPRPWNRSCV

22

FTAPVLPSALPPSPRPWNRSCV

1

FTAPVLPSALPPSPRPWNRSCV

22

95.5%

NZ_CP021707.1:

Lanthipeptides: allorf_3962821_3962985_lanthipeptide

1

FTAPVLPSALPPSPRPWNRSCV

22

F APVLPSALPPSPRPWNRSCV

1

FAAPVLPSALPPSPRPWNRSCV

22

29.2%

NZ_JALDPQ010000054.1and 1 other:

NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114966_115073_lanthipeptide

Lanthipeptides: allorf_114966_115073_lanthipeptide

13

SPRPWNRSCV

22

+P PWN SCV

15

TPPPWNWSCV

24

with 3 more sequence matches

25.0%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: allorf_3265908_3266039_lanthipeptideNZ_CP051884.1 Lanthipeptides: allorf_3265908_3266039_lanthipeptide

Lanthipeptides: allorf_3265908_3266039_lanthipeptide

5

VLPSALPPSPRPWNR

19

V +A PRPW R

9

VTRAAQTGDPRPWGR

23

22.7%

NZ_BMRY01000003.1and 5 others:

NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide

Lanthipeptides: allorf_458543_458737_lanthipeptide

12

PSPRPWNRSCV

22

PSPRPWN SCV

34

PSPRPWNWSCV

44

13.0%

NZ_BMUQ01000012.1:

Lanthipeptides: allorf_026353_026553_lanthipeptide

5

VLPSALPPSPRPWNRSC

21

P PP+ R W R+C

25

TTPLGAPPARRAWGRAC

41

allorf_250966_251172

Leader:

MSRPPRPRLLDAQRSRCGDLGKGLPMPPVRRPARPGGAAGA

Core:

AADGSGKVWNSTFRFPWSAPRSCRTLR

Core with dehydrations:

AADGDhaGKVWNDhaDhbFRFPWDhaAPRDhaCysRDhbLR

antiSMASH-DB 4.0 matches for allorf_250966_251172

100.0%

NZ_BMSZ01000006.1:

Lanthipeptides: allorf_250966_251172_lanthipeptide

1

AADGSGKVWNSTFRFPWSAPRSCRTLR

27

AADGSGKVWNSTFRFPWSAPRSCRTLR

1

AADGSGKVWNSTFRFPWSAPRSCRTLR

27

40.7%

NZ_BNBJ01000003.1and 1 other:

NZ_JAMFLF010000021.1 Lanthipeptides: allorf_030895_031062_lanthipeptide

Lanthipeptides: allorf_023401_023568_lanthipeptide

14

RFPWSAPRSCRTLR

27

R PW+ PRSCRTLR

9

RRPWNPPRSCRTLR

22

26.5%

NZ_CM000748.1and 1 other:

NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide

Lanthipeptides: BTHUR0003_RS30910_lanthipeptide

4

GSGKVWNSTFRFPWSAPRSCRTL

26

G G V T PW+ P +C T+

2

GPGWVETLTKDCPWNMPVACVTI

24

with 9 more sequence matches

26.5%

NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29280_lanthipeptide

Lanthipeptides: EXW47_RS29185_lanthipeptide

4

GSGKVWNSTFRFPWSAPRSCRTL

26

G G V T PW+ P +C T+

2

GPGWVETVTKDCPWNVPVACVTI

24

26.5%

NZ_JH792312.1and 1 other:

NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide

Lanthipeptides: IIG_RS24665_lanthipeptide

4

GSGKVWNSTFRFPWSAPRSCRTL

26

G G V T PW+ P +C T+

2

GPGWVETLTKDCPWNVPVACVTI

24

23.5%

NZ_CM000731.1and 2 others:

NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptideNZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide

Lanthipeptides: BCERE0020_RS28875_lanthipeptide

4

GSGKVWNSTFRFPWSAPRSCRTL

26

G G V T PW P +C +

2

GPGWVETLTKDCPWKQPAACVII

24

23.5%

NZ_CP036053.1and 7 others:

NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptideNZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptideNZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptideNZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptideNZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptideNZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptideNZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide

Lanthipeptides: EXW64_RS27135_lanthipeptide

4

GSGKVWNSTFRFPWSAPRSCRTL

26

G G V T PW P +C +

2

GPGWVETLTKDCPWKQPGACVII

24

23.5%

NZ_KB976276.1:

Lanthipeptides: IIC_RS09105_lanthipeptide

4

GSGKVWNSTFRFPWSAPRSCRTL

26

G G V T PW P +C +

2

GPGWVETLTKDCPWKQPVACVII

24

22.6%

NZ_QLMA01000005.1:

Lanthipeptides: CLV59_RS17395_lanthipeptide

3

DGSGKVWNSTFRFPWSAPRSCR

24

DG N++ P + SCR

9

DGGNAAANTSMGAPICSIDSCR

30

19.4%

NZ_CP041610.2:

Lanthipeptides: allorf_00759680_00759904_lanthipeptide

5

SGKVWNSTFRFPWSAPRSCRTLR

27

+G W+ + R PW P+ + R

8

TGPGWSHSCRAPWERPQEASSRR

30

16.7%

NZ_CP015883.1and 1 other:

NZ_JAASJP010000011.1 Lanthipeptides: allorf_43013_43183_lanthipeptide

Lanthipeptides: allorf_0205278_0205448_lanthipeptide

1

AADGSGKVWNSTFR

14

A+ +G +WN+ FR

13

ASINNGCMWNTVFR

26

8.6%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: allorf_1271752_1271961_lanthipeptide

Lanthipeptides: allorf_1271752_1271961_lanthipeptide

7

KVWNSTFRFPWSAP

20

+++++ R P+SAP

1

RLFSARLRVPFSAP

14

allorf_251197_251343

Leader:

MTPRHAARSQGS

Core:

FATTVRRFGRCPSEGGAEESIPPGMPPYAISPLEVR

Core with dehydrations:

FADhbDhbVRRFGRCysPDhaEGGAEEDhaIPPGMPPYAIDhaPLEVR

antiSMASH-DB 4.0 matches for allorf_251197_251343

100.0%

NZ_BMSZ01000006.1:

Lanthipeptides: allorf_251197_251343_lanthipeptide

1

FATTVRRFGRCPSEGGAEESIPPGMPPYAISPLEVR

36

FATTVRRFGRCPSEGGAEESIPPGMPPYAISPLEVR

1

FATTVRRFGRCPSEGGAEESIPPGMPPYAISPLEVR

36

97.2%

NZ_BNBJ01000003.1and 3 others:

NZ_CP079114.1 Lanthipeptides: allorf_4422232_4422378_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: allorf_130072_130218_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: allorf_031162_031308_lanthipeptide

Lanthipeptides: allorf_023668_023814_lanthipeptide

1

FATTVRRFGRCPSEGGAEESIPPGMPPYAISPLEVR

36

FATTVRRFGRCPSEGGAEE IPPGMPPYAISPLEVR

1

FATTVRRFGRCPSEGGAEEFIPPGMPPYAISPLEVR

36

97.2%

NZ_LZRD01000017.1:

Lanthipeptides: allorf_103132_103278_lanthipeptide

1

FATTVRRFGRCPSEGGAEESIPPGMPPYAISPLEVR

36

FATTVRR GRCPSEGGAEESIPPGMPPYAISPLEVR

1

FATTVRRSGRCPSEGGAEESIPPGMPPYAISPLEVR

36

with 5 more sequence matches

24.3%

NZ_QLMA01000007.1:

Lanthipeptides: CLV59_RS20825_lanthipeptide

3

TTVRRFGRCPSEGGAEESIPPG

24

TTV CP+ +IPPG

9

TTVMSIRTCPTVVDTCSTIPPG

30

22.2%

NZ_CP061072.1:

Lanthipeptides: allorf_5575476_5575628_lanthipeptide

7

RFGRCPSEGGAEESIPP

23

R+ RC GGA + PP

4

RWRRCGRVGGAAPTRPP

20

22.2%

NZ_LT629791.1:

Lassopeptides: BLV05_RS35470_lassopeptide

15

GGAEESIPPGMPPY

28

GGAE+SI PY

1

GGAEKSIEAKQRPY

14

18.4%

NZ_FMXV01000009.1:

Lanthipeptides: allorf_148352_148558_lanthipeptide

8

FGRCPSEGGAEESIPP

23

G CPS G +PP

20

IGHCPSAGHNARRLPP

35

13.9%

NZ_CP119804.1:

Lanthipeptides: allorf_1905850_1905972_lanthipeptide

5

VRRFGRCPSEGGAEE

19

+ RF RC S + +

3

INRFARCDSHHSSAD

17

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

Additional weak hits (5):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.59 out of 27.78

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.29 out of 21.55

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.69 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.60 out of 35.63

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

IE135_RS12780 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 3790.7 Da

Molecular weight: 3793.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3811.2 Da N = 1; 3829.2 Da N = 2; 3847.2 Da N = 3

IE135_RS12790 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 3793.0 Da

Molecular weight: 3795.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3813.4 Da N = 1; 3831.4 Da N = 2; 3849.5 Da N = 3; 3867.5 Da N = 4; 3885.5 Da N = 5; 3903.5 Da N = 6; 3921.5 Da N = 7

allorf_235964_236128 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 2319.3 Da

Molecular weight: 2320.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2338.7 Da N = 1; 2356.7 Da N = 2; 2374.8 Da N = 3

allorf_250966_251172 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 2944.5 Da

Molecular weight: 2946.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2964.3 Da N = 1; 2982.3 Da N = 2; 3000.3 Da N = 3; 3018.4 Da N = 4; 3036.4 Da N = 5

allorf_251197_251343 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 3783.9 Da

Molecular weight: 3786.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3804.3 Da N = 1; 3822.3 Da N = 2; 3840.3 Da N = 3; 3858.4 Da N = 4

IE135_RS12780 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 3790.7 Da

Molecular weight: 3793.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3811.2 Da N = 1; 3829.2 Da N = 2; 3847.2 Da N = 3

IE135_RS12790 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 3793.0 Da

Molecular weight: 3795.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3813.4 Da N = 1; 3831.4 Da N = 2; 3849.5 Da N = 3; 3867.5 Da N = 4; 3885.5 Da N = 5; 3903.5 Da N = 6; 3921.5 Da N = 7

allorf_229072_229176 - Class II

Cleavage pHMM score: -2.60

RODEO score: 0

Monoisotopic mass: 1841.9 Da

Molecular weight: 1843.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1861.0 Da N = 1; 1879.1 Da N = 2; 1897.1 Da N = 3; 1915.1 Da N = 4

allorf_235964_236128 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 2319.3 Da

Molecular weight: 2320.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2338.7 Da N = 1; 2356.7 Da N = 2; 2374.8 Da N = 3

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
RpoN	Regulator of nitrogen assimilation and virulence

NZ_BMSZ01000010.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 13,497 - 35,710 nt. (total: 22,214 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

IE135_RS17935: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.83	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3	0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486
BGC0000518.3	0.33	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0001002.5	0.29	NRPS, PKS	jawsamycin	Streptomyces roseoverticillatus
BGC0001818.4	0.27	NRPS	vazabitide A	Streptomyces sp. SANK 60404
BGC0001203.4	0.24	NRPS, PKS	Clarexpoxcin A, Clarexpoxcin B, Clarexpoxcin C, Clarexpoxcin D, Clarexpoxcin E	uncultured bacterium AR_456
BGC0000119.5	0.23	PKS, saccharide	7-deoxypactamycin	Streptomyces pactum
BGC0000998.5	0.23	NRPS, PKS	guadinomine, guadinomine B, guadinomic acid	Streptomyces sp. K01-0509
BGC0000118.5	0.22	PKS	pactamycin	Streptomyces pactum
BGC0000341.5	0.21	NRPS	enduracidin A, enduracidin B	Streptomyces fungicidicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.83	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3	0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486
BGC0000518.3	0.33	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0001002.5	0.29	NRPS, PKS	jawsamycin	Streptomyces roseoverticillatus
BGC0001818.4	0.27	NRPS	vazabitide A	Streptomyces sp. SANK 60404
BGC0001203.4	0.24	NRPS, PKS	Clarexpoxcin A, Clarexpoxcin B, Clarexpoxcin C, Clarexpoxcin D, Clarexpoxcin E	uncultured bacterium AR_456
BGC0000119.5	0.23	PKS, saccharide	7-deoxypactamycin	Streptomyces pactum
BGC0000998.5	0.23	NRPS, PKS	guadinomine, guadinomine B, guadinomic acid	Streptomyces sp. K01-0509
BGC0000118.5	0.22	PKS	pactamycin	Streptomyces pactum
BGC0000341.5	0.21	NRPS	enduracidin A, enduracidin B	Streptomyces fungicidicus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene		germacradienol	C15	C1-C10	OH
sesquiterpene		geosmin	C12	C1-C10	OH

Genes with terpene domains:

IE135_RS17935: T1TS + T1TS

Domain 1 (2 - 326): Type 1 terpene synthase

Subtype: Geosmin synthase, N terminal domain

Reactions:: FPP → germacradienol

Domain 2 (337 - 697): Type 1 terpene synthase

Subtype: Geosmin synthase, C terminal domain

Reactions:: germacradienol → geosmin

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.75 out of 23.79

Confidence: medium

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 24.10 out of 29.51

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.65 out of 28.19

Confidence: medium

Additional weak hits (6):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.80 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.07 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.45 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.28 out of 29.65

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.89 out of 28.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
DosR	Hypoxia stress response regulator
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

NZ_BMSZ01000010.1 - Region 2 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 75,129 - 133,748 nt. (total: 58,620 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

IE135_RS18260: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Hydrolases: esterase

IE135_RS18220: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

Lyases: dehydratase

IE135_RS18265: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

IE135_RS18230: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IE135_RS18280: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000325.5	0.96	NRPS	coelichelin	Streptomyces coelicolor A3(2)
BGC0000357.5	0.69	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.65	NRPS	AM-toxin	Alternaria alternata
BGC0001240.4	0.64	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000351.5	0.46	NRPS	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0002494.3	0.39	NRPS	vibriobactin	Vibrio cholerae
BGC0002073.3	0.39	NRPS	dehydroxynocardamine	Corynebacterium propinquum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000325.5	0.77	NRPS	coelichelin	Streptomyces coelicolor A3(2)
BGC0000357.5	0.67	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001240.4	0.65	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001166.5	0.65	NRPS	HC-toxin	Alternaria jesenskae
BGC0001758.4	0.64	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000351.5	0.56	NRPS	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0002494.3	0.52	NRPS	vibriobactin	Vibrio cholerae
BGC0002073.3	0.51	NRPS	dehydroxynocardamine	Corynebacterium propinquum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.71 out of 23.79

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.63 out of 27.04

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 24.00 out of 27.04

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.82 out of 26.85

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.76 out of 23.79

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 32.36 out of 36.53

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.30 out of 36.53

Confidence: medium

Additional weak hits (10):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.57 out of 36.53

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.96 out of 25.75

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.48 out of 29.38

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.91 out of 39.62

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.54 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.76 out of 35.63

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.81 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.99 out of 26.06

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.03 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 75128 - 133748:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Fo-OH-Orn - D-Thr - OH-Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS18230: Fo-OH-Orn - Thr - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (144..542): Fo-OH-Orn

nrpys: Fo-OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: RWQAFDISVNELYLWCGGEYHGYGPAETTIGVSH
Nearest Stachelhaus code(s):: Fo-OH-Orn DINYWGGIGK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1626..2039): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNTHFDFAVWEGNQVFGGEVNMYGITETTVHVTH
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3075..3474): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: MNHVFDMSWEEWNVLLGGEYNLYGPTEYTINTLG
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
DasR	N-acetylglucosamine dependent repressor
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMSZ01000010.1 - Region 3 - T3PKS

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Location: 176,497 - 217,630 nt. (total: 41,134 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

IE135_RS18620: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

IE135_RS18650: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

IE135_RS18730: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: kinase

IE135_RS18665: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: glucosidase protease

IE135_RS18720: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

IE135_RS18755: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: synthase

IE135_RS18640: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IE135_RS18655: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IE135_RS18660: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

IE135_RS18725: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001310.5	0.83	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.71	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.67	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.59	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0002711.2	0.52	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000280.5	0.51	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0000281.3	0.50	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002285.2	0.47	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002332.2	0.47	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0000235.5	0.46	PKS	kiamycin	Streptomyces sp. W007

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001310.5	0.83	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.71	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.67	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.59	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0002711.2	0.52	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000280.5	0.51	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0000281.3	0.50	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002285.2	0.47	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002332.2	0.47	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0000235.5	0.46	PKS	kiamycin	Streptomyces sp. W007

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.21 out of 20.97

Confidence: medium

Additional weak hits (18):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.31 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.03 out of 21.55

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.14 out of 20.01

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.30 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.81 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.03 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.58 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.00 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.11 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.09 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.71 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.48 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.55 out of 30.25

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 25.75

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.79 out of 29.38

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.76 out of 24.78

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.97 out of 26.85

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.89 out of 28.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA	Catabolite control protein A

NZ_BMSZ01000010.1 - Region 4 - terpene-precursor

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Location: 223,344 - 244,396 nt. (total: 21,053 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

IE135_RS18875: methyltransferase

smcogs: SMCOG1248: methyltransferase

Lyases: cyclase

IE135_RS34415: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Ligases: synthetase

IE135_RS18895: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.44	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000908.3	0.42	other (other)	melanin	Streptomyces avermitilis
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002640.2	0.42	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000584.5	0.41	ribosomal	colicin V	Escherichia coli
BGC0001639.3	0.41	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000517.4	0.40	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000520.5	0.40	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.44	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000908.3	0.42	other (other)	melanin	Streptomyces avermitilis
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002640.2	0.42	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000584.5	0.41	ribosomal	colicin V	Escherichia coli
BGC0001639.3	0.41	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000517.4	0.40	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000520.5	0.40	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

IE135_RS18895: PT_FPPS_like

Domain 1 (48 - 343): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.64 out of 23.79

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.41 out of 27.04

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.79 out of 25.31

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.54 out of 23.79

Confidence: medium

Additional weak hits (6):

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.35 out of 27.18

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.77 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.96 out of 29.65

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.75 out of 35.63

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.46 out of 27.04

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.99 out of 35.63

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
DasR	N-acetylglucosamine dependent repressor
IolR	Regulator of the inositol catabolism

NZ_BMSZ01000011.1 - Region 1 - terpene

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Location: 1 - 28,919 nt. (total: 28,919 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IE135_RS19210: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

IE135_RS19290: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

Transferases: kinase methyltransferase

IE135_RS19230: methyltransferase

smcogs: SMCOG1089: methyltransferase

IE135_RS19275: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Isomerases: mutase

IE135_RS19285: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: synthetase

IE135_RS19205: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.84	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.76	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.70	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.69	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.68	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000645.3	0.55	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000648.3	0.53	terpene	carotenoid	Myxococcus xanthus
BGC0000650.3	0.52	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000646.5	0.51	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.50	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.84	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.76	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.70	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.69	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.68	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000645.3	0.55	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000648.3	0.53	terpene	carotenoid	Myxococcus xanthus
BGC0000650.3	0.52	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000646.5	0.51	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.50	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

IE135_RS19205: PT_FPPS_like

Domain 1 (71 - 371): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

IE135_RS19215: PT_phytoene_like

Domain 1 (16 - 320): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → PSPP; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

IE135_RS19240: Lycopene_cycl

Domain 1 (6 - 382): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.90 out of 27.78

Confidence: medium

Additional weak hits (13):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.45 out of 18.57

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.11 out of 30.22

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.69 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.22 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.05 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.96 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.66 out of 36.54

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.75 out of 29.38

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.38 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.88 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.10 out of 29.65

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMSZ01000011.1 - Region 2 - NRPS,T1PKS

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Location: 38,499 - 90,783 nt. (total: 52,285 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

IE135_RS19365: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IE135_RS19395: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

IE135_RS19470: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

IE135_RS19490: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

Transferases: acylase

IE135_RS19440: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

IE135_RS19485: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Translocases: transporter

IE135_RS19505: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.65	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.59	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.57	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2	0.54	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001164.3	0.53	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.53	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.63	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

Additional weak hits (13):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.70 out of 36.54

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.37 out of 25.88

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.58 out of 18.57

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.85 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.44 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.63 out of 27.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.53 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.13 out of 30.22

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.20 out of 35.63

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.96 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 38498 - 90783:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - ohmal - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS19440: fatty_acid - mal - X

CAL_domain (43..459): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 45.5
NH2: 44.4
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

PKS_AT (1218..1500): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 118.2
Methylmalonyl-CoA: 70.9
Methoxymalonyl-CoA: 65.5
inactive: 46.4
Ethylmalonyl-CoA: 31.2
fatty_acid: 30.1
Propionyl-CoA: 25.6
Isobutyryl-CoA: 24.9
trans-1,2-CPDA: 19.6
2-Methylbutyryl-CoA: 18.7
CHC-CoA: 16.0
Benzoyl-CoA: 11.2
Acetyl-CoA: 10.6
3-Methylbutyryl-CoA: 8.3

AMP-binding (2629..3044): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YWAAFDASVRQASSHVGGEANLYGPTEATINTSC
Nearest Stachelhaus code(s):: Gln DACSTGVINK (50% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMSZ01000011.1 - Region 3 - T3PKS

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Location: 168,503 - 209,555 nt. (total: 41,053 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

IE135_RS19920: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

IE135_RS20000: oxidoreductase

smcogs: SMCOG1161: oxidoreductase

Transferases: kinase methyltransferase

IE135_RS19925: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

IE135_RS20005: Methylation

MITE: MITE0000155Methylation (identity: 87.90%)
smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Ligases: ligase synthase

IE135_RS19965: carboxylate-amine ligase

smcogs: SMCOG1165: carboxylate-amine ligase

IE135_RS20010: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Translocases: transporter

IE135_RS19905: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.88	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.53	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001647.3	0.46	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0001927.4	0.44	other (other)	A-94964	Streptomyces sp.
BGC0002358.3	0.44	PKS	cyclofaulknamycin	Streptomyces albidoflavus
BGC0001965.4	0.42	other (other)	nybomycin	Streptomyces albus subsp. chlorinus
BGC0001377.5	0.41	PKS	uncialamycin	Streptomyces uncialis
BGC0001610.5	0.41	other (other)	gougerotin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001964.2	0.41	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001366.5	0.41	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.88	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.53	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001647.3	0.46	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0001927.4	0.44	other (other)	A-94964	Streptomyces sp.
BGC0002358.3	0.44	PKS	cyclofaulknamycin	Streptomyces albidoflavus
BGC0001965.4	0.42	other (other)	nybomycin	Streptomyces albus subsp. chlorinus
BGC0001377.5	0.41	PKS	uncialamycin	Streptomyces uncialis
BGC0001610.5	0.41	other (other)	gougerotin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001964.2	0.41	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001366.5	0.41	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.20 out of 23.79

Confidence: medium

Additional weak hits (9):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.88 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.13 out of 30.97

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.81 out of 29.65

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.73 out of 36.53

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.17 out of 29.51

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.44 out of 32.74

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.81 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.93 out of 24.78

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.27 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_BMSZ01000011.1 - Region 4 - melanin,terpene-precursor

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Location: 217,825 - 245,568 nt. (total: 27,744 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
melanin: melC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

IE135_RS20280: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: glycosyltransferase

IE135_RS20225: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

IE135_RS20230: sugar transferase

smcogs: SMCOG1146: sugar transferase

IE135_RS20250: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Ligases: synthetase

IE135_RS20220: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000911.3	0.63	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3	0.50	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000909.3	0.31	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.26	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000800.5	0.25	saccharide	xanthan	Xanthomonas campestris
BGC0001529.5	0.22	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0000786.3	0.21	saccharide	O-antigen	Edwardsiella ictaluri 93-146
BGC0000790.3	0.17	saccharide	O-antigen	Escherichia coli
BGC0000908.3	0.17	other (other)	melanin	Streptomyces avermitilis
BGC0000742.3	0.16	saccharide	capsular polysaccharide	Streptococcus agalactiae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000911.3	0.86	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3	0.79	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000909.3	0.64	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.59	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002397.2	0.53	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.50	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000908.3	0.48	other (other)	melanin	Streptomyces avermitilis
BGC0000677.5	0.48	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000742.3	0.47	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000743.3	0.47	saccharide	capsular polysaccharide	Streptococcus agalactiae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

IE135_RS20220: PT_FPPS_like

Domain 1 (57 - 340): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.74 out of 28.14

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.20 out of 21.55

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.61 out of 26.85

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.49 out of 39.62

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_BMSZ01000011.1 - Region 5 - RiPP-like

Download region GenBank file

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Location: 247,961 - 259,328 nt. (total: 11,368 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.71	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002531.3	0.38	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0000571.3	0.37	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002073.3	0.37	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0000488.4	0.36	ribosomal	circularin A	Clostridium beijerinckii
BGC0002682.2	0.35	other (other)	aerobactin	Vibrio mimicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.71	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002531.3	0.38	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0000571.3	0.37	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002073.3	0.37	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0000488.4	0.36	ribosomal	circularin A	Clostridium beijerinckii
BGC0002682.2	0.35	other (other)	aerobactin	Vibrio mimicus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (5):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 15.90 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.66 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.12 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.02 out of 28.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.28 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_BMSZ01000013.1 - Region 1 - NRPS,transAT-PKS

Download region GenBank file

Download region SVG

Location: 128,306 - 192,127 nt. (total: 63,822 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acylase

IE135_RS22575: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase

IE135_RS22580: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

IE135_RS22555: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS22560: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IE135_RS22565: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS22570: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IE135_RS22600: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS22605: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IE135_RS22610: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS22625: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.83	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.79	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.78	NRPS	HC-toxin	Alternaria jesenskae
BGC0001132.4	0.76	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.76	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.74	NRPS	enniatin	Fusarium equiseti
BGC0002286.3	0.74	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001250.4	0.73	NRPS	epichloenin A	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.71	NRPS	HC-toxin	Alternaria jesenskae
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.70	NRPS	enniatin	Fusarium equiseti
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001250.4	0.69	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.80 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

Additional weak hits (8):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.65 out of 27.55

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.73 out of 19.26

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.28 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.91 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.06 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.02 out of 26.06

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.42 out of 26.85

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.99 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 128305 - >192127:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gln) + (mal) + (Gly) + (Pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS22555: Gln

Search NORINE for peptide: strict or relaxed

AMP-binding (476..877): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: NWKTFDASVWEAQFFCGGEVNLYGPTEATIDATF
Nearest Stachelhaus code(s):: Gln DAWQFGLIDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

IE135_RS22565: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (535..934): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: LALTFDIAVLEWQALVGGEVNMYGPTETTVWSSA
Nearest Stachelhaus code(s):: Gly DILQLGMVWK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

IE135_RS22570: Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (1361..1760): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LWEAFDAAFHEAILATTGEINNYGPAETHVVTSY
Nearest Stachelhaus code(s):: Leu or Tyr DAWFLGNVVK (62% 8Å match); Leu DAWFLGNVVK (59% 8Å match)
Stachelhaus code match:: 60% (weak)

IE135_RS22575: mal

PKS_AT (25..309): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 96.8
Methoxymalonyl-CoA: 57.0
Methylmalonyl-CoA: 40.5
Propionyl-CoA: 28.5
fatty_acid: 26.2
Ethylmalonyl-CoA: 23.9
2-Methylbutyryl-CoA: 22.3
Isobutyryl-CoA: 20.9
CHC-CoA: 17.0
trans-1,2-CPDA: 11.9
Benzoyl-CoA: 10.9
Acetyl-CoA: 8.8
inactive: 0.8
3-Methylbutyryl-CoA: 0.0

IE135_RS22600: X

AMP-binding (15..412): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IDGAWDMYAYEGRLYVGGEVNGYGPAESCMHATS
Nearest Stachelhaus code(s):: Lys DMYNFGLIHK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

IE135_RS22610: X

AMP-binding (4..192): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LVM-----VMRLDL-----FNQYGPTETHSVSSL
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

IE135_RS22625: X

AMP-binding (67..503): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ANPFHVAAFTSGAGSTGGARNGYGLTETSGGVLA
Nearest Stachelhaus code(s):: Ppa VATFIGGAGK (41% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism

NZ_BMSZ01000015.1 - Region 1 - NRPS-like,terpene

Download region GenBank file

Download region SVG

Location: 213,435 - 245,727 nt. (total: 32,293 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IE135_RS25300: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Transferases: aminotransferase

IE135_RS25320: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: hydrolase

IE135_RS25330: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Isomerases: mutase

IE135_RS25325: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.30	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.30	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.30	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.29	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.29	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.29	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.29	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	0.28	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.28	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.27	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.63	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	0.62	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.62	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
triterpene		squalene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

IE135_RS25275: PT_phytoene_like

Domain 1 (1 - 248): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → PSPP; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.63 out of 18.46

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52

Confidence: medium

Additional weak hits (12):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.27 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.20 out of 27.78

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.53 out of 27.04

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.29 out of 23.43

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.80 out of 19.26

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.63 out of 25.88

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.19 out of 31.73

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.54 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.79 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.26 out of 24.78

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.51 out of 26.85

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.67 out of 25.75

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 213434 - 245727:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Gly)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 221468 - 245727:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS25365: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (138..553): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDIHVLELQALVGGETNLYGPTEATVWATT
Nearest Stachelhaus code(s):: Gly DILQLGLVWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence

NZ_BMSZ01000016.1 - Region 1 - deazapurine

Download region GenBank file

Download region SVG

Location: 162,474 - 184,816 nt. (total: 22,343 nt) Show pHMM detection rules used

deazapurine: (GTP_cyclohydroI and PTPS and QueE and QueC and not (dpdA1 or bTGT))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IE135_RS26075: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

IE135_RS26080: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: esterase

IE135_RS26170: putative esterase

smcogs: SMCOG1104: putative esterase

Lyases: lyase

IE135_RS26095: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

IE135_RS26130: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

IE135_RS26145: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002354.4	0.62	other (other)	huimycin	Kutzneria albida DSM 43870
BGC0000802.5	0.61	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0001808.5	0.60	other (other)	toyocamycin	Streptomyces diastatochromogenes
BGC0000881.3	0.60	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001937.4	0.56	other (other)	tubercidin	Streptomyces tubercidicus
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.49	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002313.3	0.47	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000879.5	0.45	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002354.4	0.62	other (other)	huimycin	Kutzneria albida DSM 43870
BGC0000802.5	0.61	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0001808.5	0.60	other (other)	toyocamycin	Streptomyces diastatochromogenes
BGC0000881.3	0.60	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001937.4	0.56	other (other)	tubercidin	Streptomyces tubercidicus
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.49	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002313.3	0.47	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000879.5	0.45	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (6):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.62 out of 29.51

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.10 out of 30.25

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.92 out of 20.97

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.00 out of 32.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.16 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_BMSZ01000017.1 - Region 1 - NRPS,NRPS-like

Download region GenBank file

Download region SVG

Location: 1 - 30,070 nt. (total: 30,070 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase phosphate reductase

IE135_RS26380: N-acetyl-gamma-glutamyl-phosphate reductase

smcogs: SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase

IE135_RS26420: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acyltransferase aminotransferase kinase

IE135_RS26390: acetylglutamate kinase

smcogs: SMCOG1174: acetylglutamate kinase

IE135_RS26395: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

IE135_RS26440: acyltransferase

smcogs: SMCOG1141: acyltransferase

Hydrolases: deaminase esterase

IE135_RS26360: thioesterase

smcogs: SMCOG1004: thioesterase

IE135_RS26370: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Lyases: lyase

IE135_RS26415: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase

IE135_RS26340: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IE135_RS26350: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IE135_RS26365: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS26375: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

IE135_RS26410: argininosuccinate synthase

smcogs: SMCOG1291: argininosuccinate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.82	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.79	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.79	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.77	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001261.3	0.75	NRPS	AM-toxin	Alternaria alternata
BGC0000431.5	0.75	NRPS	stenothricin	Streptomyces filamentosus NRRL 15998
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.71	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000431.5	0.70	NRPS	stenothricin	Streptomyces filamentosus NRRL 15998
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.68	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

Additional weak hits (7):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.55 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.69 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.21 out of 27.78

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.73 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.46 out of 26.06

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.54 out of 30.97

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 30070:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 24388:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS26350: X

AMP-binding (464..866): X

nrpys: CysA

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YRCAFDAGVTAGKAMVGGEVNHYGPTEVTVGCTD
Nearest Stachelhaus code(s):: CysA DATKMGHVGK (100% 8Å match); Asp DATKMGHVGK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

IE135_RS26365: X

AMP-binding (221..623): X

nrpys: Dpr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HAKAFDISLWQSQISVTGEVNAYGLTETSDDTNH
Nearest Stachelhaus code(s):: Dpr DIWQSTADDK (100% 8Å match); dnmeProp or Dab DIWQSTADDK (85% 8Å match); Asp DIWQSTADDK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_BMSZ01000017.1 - Region 2 - terpene

Download region GenBank file

Download region SVG

Location: 125,905 - 146,984 nt. (total: 21,080 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IE135_RS26980: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: formyltransferase

IE135_RS26950: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Lyases: cyclase hydratase

IE135_RS26970: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

IE135_RS26990: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002708.2	0.76	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0002707.2	0.47	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000631.5	0.37	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10
BGC0002034.3	0.36	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000879.5	0.35	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001677.3	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0002616.2	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0001360.3	0.34	PKS	mycophenolic acid	Penicillium roqueforti FM164
BGC0002619.2	0.34	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0000881.3	0.33	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002708.2	0.76	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0002707.2	0.47	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000631.5	0.37	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10
BGC0002034.3	0.36	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000879.5	0.35	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001677.3	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0002616.2	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0001360.3	0.34	PKS	mycophenolic acid	Penicillium roqueforti FM164
BGC0002619.2	0.34	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0000881.3	0.33	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
monoterpene			C10	C1-C10	none
sesquiterpene			C15	C1-C10	none

Genes with terpene domains:

IE135_RS26970: T1TS

Domain 1 (4 - 315): Type 1 terpene synthase

Subtype: Germacrene A synthase type

Reactions:: GPP → monoterpene_C1-C10; FPP → sesquiterpene_C1-C10

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.50 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.10 out of 23.79

Confidence: medium

Additional weak hits (16):

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.87 out of 32.93

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.97 out of 39.62

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.37 out of 26.12

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.70 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.18 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.76 out of 26.06

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.15 out of 18.57

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.23 out of 20.97

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.86 out of 27.78

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.84 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.72 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.62 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GPP	Geranyl diphoshate

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_BMSZ01000021.1 - Region 1 - ectoine

Download region GenBank file

Download region SVG

Location: 37,136 - 47,534 nt. (total: 10,399 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

IE135_RS29750: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: aminotransferase

IE135_RS29740: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

IE135_RS29770: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

IE135_RS29780: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.92	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.62	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.92	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.62	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (9):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.51 out of 27.78

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.04 out of 26.12

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.74 out of 30.25

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.75 out of 21.55

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.46 out of 27.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.49 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.18 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.67 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_BMSZ01000022.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 56,339 - 93,590 nt. (total: 37,252 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

IE135_RS30410: Dioxygenase TauD/TfdA

smcogs: SMCOG1046: Dioxygenase TauD/TfdA

Hydrolases: hydrolase

IE135_RS30400: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase

IE135_RS30440: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IE135_RS30445: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.73	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.73	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.42 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.42 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.42 out of 20.47

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.68 out of 24.78

Confidence: medium

Additional weak hits (7):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.42 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.63 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.04 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.63 out of 31.73

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.83 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.06 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.77 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 56338 - 93590:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Pro - Gly - D-Thr) + (Val - Pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS30440: Val - Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (470..871): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDGSFDAATWEVWLWTGGDANGYGPTETTTFALA
Nearest Stachelhaus code(s):: Val DAYWWGGTFK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1564..1970): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHTFDVSVQESYAAQAGERNHYGPSETHVVTAA
Nearest Stachelhaus code(s):: Pro DVQYAAHVVK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

IE135_RS30445: Pro - Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (70..474): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHTFDVSVQESYAAQAGELNHYGPAESHVVTAY
Nearest Stachelhaus code(s):: Pro DVQYAAHVVK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1139..1531): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDIAGLELQALVGGETNLYGPTETTIWSTA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2213..2625): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LTTHFDFSVWEGNQVFGGEVNMYGITETTVHVSH
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMSZ01000023.1 - Region 1 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 45,572 - 78,301 nt. (total: 32,730 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

IE135_RS30720: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: aminotransferase

IE135_RS30675: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Isomerases: mutase

IE135_RS30725: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.55	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002683.2	0.51	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001531.5	0.51	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002633.2	0.51	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002470.2	0.50	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.55	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002683.2	0.51	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001531.5	0.51	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002633.2	0.51	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002470.2	0.50	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.58 out of 23.05

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.04 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.17 out of 23.79

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.93 out of 24.78

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 24.17 out of 27.18

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.81 out of 27.18

Confidence: medium

Additional weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.39 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.25 out of 30.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.88 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.09 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.77 out of 25.88

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.45 out of 23.43

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
NrdR	Represses ribonucleotide reductase encoding genes

NZ_BMSZ01000025.1 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 8,943 - 66,291 nt. (total: 57,349 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IE135_RS31295: nucleotide sugar dehydrogenase

smcogs: SMCOG1152: nucleotide sugar dehydrogenase

IE135_RS31310: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

IE135_RS31320: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Transferases: acylase glycosyltransferase

IE135_RS31325: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

IE135_RS35235: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase

IE135_RS31355: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

IE135_RS31290: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

IE135_RS31305: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IE135_RS31315: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

IE135_RS31335: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IE135_RS31360: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.74	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.74	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001522.5	0.70	PKS	auroramycin	Streptomyces filamentosus
BGC0000041.3	0.66	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000067.5	0.63	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.74	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.74	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001522.5	0.70	PKS	auroramycin	Streptomyces filamentosus
BGC0000041.3	0.66	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000067.5	0.63	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.38 out of 19.26

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 24.03 out of 27.04

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52

Confidence: medium

Additional weak hits (9):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.21 out of 26.85

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.30 out of 18.57

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.25 out of 21.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.70 out of 30.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.42 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.07 out of 29.65

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.56 out of 21.84

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 8942 - 66291:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal) + (ccmal - ccmal) + (ccmal - ccmal)
Non-colinear ordering:: IE135_RS35235 + IE135_RS31335 + IE135_RS31305

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS31305: mal - mal

PKS_AT (557..850): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 167.6
inactive: 84.3
Methylmalonyl-CoA: 67.5
Methoxymalonyl-CoA: 64.7
Propionyl-CoA: 39.8
Benzoyl-CoA: 35.6
Ethylmalonyl-CoA: 35.3
Isobutyryl-CoA: 27.8
Acetyl-CoA: 25.3
2-Methylbutyryl-CoA: 20.1
fatty_acid: 16.0
CHC-CoA: 15.0
trans-1,2-CPDA: 14.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2295..2590): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%; CE-Malonyl-CoA: 54.2%; Ethylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 119.2
Methoxymalonyl-CoA: 55.4
Methylmalonyl-CoA: 54.2
inactive: 47.4
Ethylmalonyl-CoA: 26.1
Acetyl-CoA: 15.2
CHC-CoA: 14.4
Benzoyl-CoA: 12.3
fatty_acid: 10.9
Isobutyryl-CoA: 10.4
trans-1,2-CPDA: 9.4
3-Methylbutyryl-CoA: 8.7
Propionyl-CoA: 8.2
2-Methylbutyryl-CoA: 0.0

IE135_RS35235: mmal

PKS_AT (558..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.8
Ethylmalonyl-CoA: 191.0
Methoxymalonyl-CoA: 165.3
trans-1,2-CPDA: 120.0
2-Methylbutyryl-CoA: 118.7
Propionyl-CoA: 103.3
CHC-CoA: 98.4
Malonyl-CoA: 98.2
Isobutyryl-CoA: 92.8
Benzoyl-CoA: 69.5
Acetyl-CoA: 52.7
3-Methylbutyryl-CoA: 39.3
inactive: 39.2
fatty_acid: 27.0

IE135_RS31335: mal - mal

PKS_AT (582..876): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.6
inactive: 106.6
Methoxymalonyl-CoA: 65.9
Methylmalonyl-CoA: 52.7
Propionyl-CoA: 27.6
Isobutyryl-CoA: 21.3
fatty_acid: 16.4
Ethylmalonyl-CoA: 15.5
Acetyl-CoA: 15.1
Benzoyl-CoA: 12.7
CHC-CoA: 9.9
2-Methylbutyryl-CoA: 7.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2336..2628): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 196.3
inactive: 93.2
Methoxymalonyl-CoA: 64.9
Methylmalonyl-CoA: 51.9
Isobutyryl-CoA: 25.8
Propionyl-CoA: 15.9
Ethylmalonyl-CoA: 15.3
Acetyl-CoA: 14.2
Benzoyl-CoA: 7.7
fatty_acid: 5.0
CHC-CoA: 1.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CRP	Cyclic AMP receptor protein
DasR	N-acetylglucosamine dependent repressor

NZ_BMSZ01000027.1 - Region 1 - terpene

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Location: 24,826 - 45,803 nt. (total: 20,978 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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KnownClusterBlast

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase hydrolase

IE135_RS31805: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

IE135_RS31820: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Lyases: cyclase hydratase

IE135_RS31795: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

IE135_RS31830: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002196.2	0.30	PKS	clavatol	Penicillium crustosum
BGC0000913.3	0.29	other (other)	MK-8	Enterobacter cloacae
BGC0002553.2	0.29	other (other)	tunicamycin	Rathayibacter iranicus
BGC0001866.4	0.29	PKS	viriditoxin	Byssochlamys spectabilis
BGC0002034.3	0.28	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000252.5	0.28	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000518.3	0.28	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000875.4	0.28	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0000243.4	0.27	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000157.5	0.27	PKS	tautomycetin	Streptomyces sp. CK4412

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002196.2	0.30	PKS	clavatol	Penicillium crustosum
BGC0000913.3	0.29	other (other)	MK-8	Enterobacter cloacae
BGC0002553.2	0.29	other (other)	tunicamycin	Rathayibacter iranicus
BGC0001866.4	0.29	PKS	viriditoxin	Byssochlamys spectabilis
BGC0002034.3	0.28	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000252.5	0.28	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000518.3	0.28	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000875.4	0.28	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0000243.4	0.27	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000157.5	0.27	PKS	tautomycetin	Streptomyces sp. CK4412

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

IE135_RS31795: T1TS

Domain 1 (1 - 305): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

Additional weak hits (13):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.99 out of 27.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.49 out of 30.97

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.14 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.26 out of 28.14

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.40 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.61 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.01 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.47 out of 27.78

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.12 out of 30.98

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.23 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_BMSZ01000028.1 - Region 1 - NRPS-like

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Location: 1 - 30,917 nt. (total: 30,917 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

Gene overview

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NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

IE135_RS31935: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: synthase

IE135_RS31920: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.61	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001249.5	0.60	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001240.4	0.60	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.60	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.61	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001249.5	0.60	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001240.4	0.60	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.60	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.65 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 26.66 out of 30.11

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 26.66 out of 30.11

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.28 out of 27.04

Confidence: medium

Additional weak hits (2):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.33 out of 30.25

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 30917:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS31920: X

AMP-binding (77..462): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: MSMAFDPSVMEGIMVLGGEVNVYGPTEATVFVTA
Nearest Stachelhaus code(s):: Val DAMFVGGVFK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor
DasR	N-acetylglucosamine dependent repressor

NZ_BMSZ01000028.1 - Region 2 - butyrolactone

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Location: 37,789 - 48,676 nt. (total: 10,888 nt) Show pHMM detection rules used

Region on contig edge.

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IE135_RS32045: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

IE135_RS32080: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.86	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.83	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.49	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001633.3	0.41	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001858.2	0.38	PKS	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000194.5	0.38	PKS	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000041.3	0.36	PKS	oronofacic acid	Pseudomonas syringae
BGC0001964.2	0.35	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001386.5	0.35	PKS	JBIR-76, JBIR-77	Streptomyces sp. RI-77

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.86	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.83	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.49	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001633.3	0.41	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001858.2	0.38	PKS	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000194.5	0.38	PKS	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000041.3	0.36	PKS	oronofacic acid	Pseudomonas syringae
BGC0001964.2	0.35	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001386.5	0.35	PKS	JBIR-76, JBIR-77	Streptomyces sp. RI-77

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.26 out of 23.79

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (2):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.36 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.53 out of 28.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMSZ01000029.1 - Region 1 - ectoine,t3nrps-iterative

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Location: 10,277 - 54,324 nt. (total: 44,048 nt) Show pHMM detection rules used

t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

IE135_RS32275: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

IE135_RS32285: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: aminotransferase

IE135_RS32295: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Lyases: decarboxylase

IE135_RS32315: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase

IE135_RS32305: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.67	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.66	other (ectoine)	ectoine	Streptomyces sp.
BGC0000859.3	0.63	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.62	other (other)	ectoine	Methylophaga thalassica
BGC0000857.3	0.54	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.53	other (other)	ectoine	Methylarcula marina
BGC0000852.5	0.47	other (other)	ectoine	Sporosarcina pasteurii
BGC0000854.3	0.46	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000855.3	0.44	other (other)	ectoine	Methylomicrobium kenyense
BGC0000858.3	0.44	other (other)	ectoine	Methylobacter marinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.68	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.67	other (ectoine)	ectoine	Streptomyces sp.
BGC0000859.3	0.65	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.65	other (other)	ectoine	Methylophaga thalassica
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.62	other (other)	ectoine	Methylarcula marina
BGC0001641.4	0.58	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000854.3	0.57	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000852.5	0.57	other (other)	ectoine	Sporosarcina pasteurii
BGC0000855.3	0.55	other (other)	ectoine	Methylomicrobium kenyense

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (8):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.04 out of 18.57

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.04 out of 18.57

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.22 out of 30.25

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.42 out of 28.19

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.28 out of 23.43

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.42 out of 36.53

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

IE135_RS32305: X

AMP-binding (12..409): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SAILFDYGLYQLPGTNTGAQVMYGLTECKRTAIM
Nearest Stachelhaus code(s):: Asp DYYPTTMRAK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production

NZ_BMSZ01000030.1 - Region 1 - lassopeptide

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Location: 1 - 21,614 nt. (total: 21,614 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

IE135_RS32480: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.3	0.87	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001550.3	0.73	ribosomal	citrulassin D	Streptomyces katrae
BGC0001507.3	0.66	ribosomal	anantin C	Streptomyces olindensis
BGC0001552.3	0.64	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001549.3	0.62	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001645.3	0.61	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0000578.3	0.60	ribosomal	SRO15-2005	Streptomyces filamentosus NRRL 15998
BGC0001551.4	0.60	ribosomal	citrulassin E	Streptomyces glaucescens
BGC0001493.5	0.60	ribosomal	achromosin	Streptomyces achromogenes subsp. achromogenes
BGC0002318.2	0.60	ribosomal	canucin A, canucin B	Streptomyces canus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.3	0.87	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001550.3	0.73	ribosomal	citrulassin D	Streptomyces katrae
BGC0001507.3	0.66	ribosomal	anantin C	Streptomyces olindensis
BGC0001552.3	0.64	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001549.3	0.62	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001645.3	0.61	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0000578.3	0.60	ribosomal	SRO15-2005	Streptomyces filamentosus NRRL 15998
BGC0001551.4	0.60	ribosomal	citrulassin E	Streptomyces glaucescens
BGC0001493.5	0.60	ribosomal	achromosin	Streptomyces achromogenes subsp. achromogenes
BGC0002318.2	0.60	ribosomal	canucin A, canucin B	Streptomyces canus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for IE135_RS32485

IE135_RS32485

Leader:

MKPQKQQKKAYVKPSMFQQGDFSKKTA

Full core:

GYFVGSYKEYWSRRII

Putative macrolactam:

GYFVGSYKE

antiSMASH-DB 4.0 matches for IE135_RS32485

100.0%

NZ_BMRY01000001.1and 14 others:

NZ_BMSZ01000030.1 Lassopeptides: IE135_RS32485_lassopeptideNZ_CP010833.1 Lassopeptides: TK78_RS35300_lassopeptideNZ_CP021707.1 Lassopeptides: CCZ36_RS19605_lassopeptideNZ_CP084357.1 Lassopeptides: LEL86_RS33655_lassopeptideNZ_DS999644.1 Lassopeptides: SSGG_RS36910_lassopeptideNZ_JNLT01000024.1 Lassopeptides: CD02_RS38355_lassopeptideNZ_KZ679082.1 Lassopeptides: C6W96_RS19995_lassopeptideNZ_KZ819154.1 Lassopeptides: DBP12_RS14735_lassopeptideNZ_KZ819178.1 Lassopeptides: DBP20_RS19850_lassopeptideNZ_KZ819182.1 Lassopeptides: DBP21_RS20195_lassopeptideNZ_LACR01000007.1 Lassopeptides: YW5_RS36195_lassopeptideNZ_LZRD01000023.1 Lassopeptides: A3Q37_RS36590_lassopeptideNZ_NNBN01000001.1 Lassopeptides: CG717_RS32755_lassopeptideNZ_WWGD01000017.1 Lassopeptides: GTY72_RS09250_lassopeptide

Lassopeptides: IE140_RS06105_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYFVGSYKEYWSRRII

1

GYFVGSYKEYWSRRII

16

93.8%

NZ_CP013738.1and 4 others:

NZ_CP029361.1 Lassopeptides: DIJ69_RS14415_lassopeptideNZ_CP090837.1 Lassopeptides: LZ559_RS19885_lassopeptideNZ_JAJUKK010000001.1 Lassopeptides: LXH09_RS00260_lassopeptideNZ_LIXK01000001.1 Lassopeptides: AMK23_RS36895_lassopeptide

Lassopeptides: WQO_RS35795_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYFVGSYKEYW+RRII

1

GYFVGSYKEYWTRRII

16

87.5%

NZ_AQRK01000073.1and 34 others:

NZ_ARPF01000020.1 Lassopeptides: B083_RS1000000135975_lassopeptideNZ_BMSP01000033.1 Lassopeptides: IE150_RS31095_lassopeptideNZ_BNBJ01000018.1 Lassopeptides: IE304_RS27885_lassopeptideNZ_CP011522.1 Lassopeptides: ABE83_RS36070_lassopeptideNZ_CP015362.1 Lassopeptides: A6E92_RS32825_lassopeptideNZ_CP020570.1 Lassopeptides: B1H20_RS34515_lassopeptideNZ_CP024957.1 Lassopeptides: CVT27_RS18750_lassopeptideNZ_CP030930.1 Lassopeptides: DTW94_RS18860_lassopeptideNZ_CP032543.1 Lassopeptides: D6270_RS18940_lassopeptideNZ_CP058556.1 Lassopeptides: HXS80_RS15025_lassopeptideNZ_CP059898.1 Lassopeptides: H3V39_RS14565_lassopeptideNZ_CP070242.1 Lassopeptides: I6J39_RS14950_lassopeptideNZ_CP070260.1 Lassopeptides: I6J40_RS19545_lassopeptideNZ_CP077652.1 Lassopeptides: KRR37_RS18710_lassopeptideNZ_CP079114.1 Lassopeptides: KV381_RS20695_lassopeptideNZ_CP101140.1 Lassopeptides: NF554_RS14180_lassopeptideNZ_CP101397.1 Lassopeptides: NLU04_RS02420_lassopeptideNZ_CP113262.1 Lassopeptides: OUQ49_RS18920_lassopeptideNZ_JAGGOV010000040.1 Lassopeptides: J7E92_RS24040_lassopeptideNZ_JAHHWT010000002.1 Lassopeptides: KM153_RS04955_lassopeptideNZ_JAJDST010000050.1 Lassopeptides: LJC81_RS32430_lassopeptideNZ_JALDPQ010000042.1 Lassopeptides: MQC87_RS04740_lassopeptideNZ_JAMFLF010000013.1 Lassopeptides: M1212_RS26530_lassopeptideNZ_JANRMN010000006.1 Lassopeptides: NW249_RS11850_lassopeptideNZ_KB890924.1 Lassopeptides: B053_RS1000000136555_lassopeptideNZ_KB891296.1 Lassopeptides: B061_RS39115_lassopeptideNZ_KL573564.1 Lassopeptides: BG84_RS1000000139430_lassopeptideNZ_KZ819159.1 Lassopeptides: DBP19_RS18270_lassopeptideNZ_LR881952.1 Lassopeptides: STRPST75_RS15280_lassopeptideNZ_LZQS01000001.1 Lassopeptides: STIB_RS37415_lassopeptideNZ_RCOL01000001.1 Lassopeptides: STAN_RS20170_lassopeptideNZ_VEHK01000003.1 Lassopeptides: FS984_RS09665_lassopeptideNZ_WUEJ01000001.1 Lassopeptides: GRQ63_RS00790_lassopeptideNZ_WWGL01000031.1 Lassopeptides: GTY38_RS20560_lassopeptide

Lassopeptides: YUW_RS35360_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYF GSYKEYW RRII

1

GYFYGSYKEYWVRRII

16

with 12 more sequence matches

Only the first 10 are displayed here.

87.5%

NZ_BDHJ01000011.1and 4 others:

NZ_BMTW01000001.1 Lassopeptides: IE134_RS04135_lassopeptideNZ_CP076457.1 Lassopeptides: KME66_RS14195_lassopeptideNZ_KZ268499.1 Lassopeptides: CE422_RS34520_lassopeptideNZ_ML123117.1 Lassopeptides: EES46_RS05210_lassopeptide

Lassopeptides: BHQ08_RS34645_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYFVGSYKEYW+RRI+

1

GYFVGSYKEYWTRRIV

16

87.5%

NZ_CP020563.1:

Lassopeptides: B7C62_RS35255_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYF+GSYKE+WSRRII

1

GYFIGSYKEFWSRRII

16

82.4%

NC_021177.1and 5 others:

NZ_BMUG01000007.1 Lassopeptides: IE264_RS21365_lassopeptideNZ_CP054926.1 Lassopeptides: HUT09_RS19455_lassopeptideNZ_CP068598.1 Lassopeptides: IFE09_RS19740_lassopeptideNZ_CP071044.1 Lassopeptides: JHY03_RS19320_lassopeptideNZ_JOJC01000016.1 Lassopeptides: IO23_RS1000000136610_lassopeptide

Lassopeptides: SFUL_RS36235_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYFVGSYKEYW RRI+

1

GYFVGSYKEYWVRRIV

16

81.2%

NZ_CP110539.1and 1 other:

NZ_CP112880.1 Lassopeptides: N7925_RS15605_lassopeptide

Lassopeptides: OH133_RS17115_lassopeptide

1

GYFVGSYKEYWSRRI

15

GYF GSYKEYW RRI

1

GYFYGSYKEYWVRRI

15

75.0%

NZ_FOET01000001.1:

Lassopeptides: BMY40_RS27365_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYFVG YKEY+SRR +

1

GYFVGKYKEYFSRRFV

16

75.0%

NZ_KB891808.1:

Lassopeptides: B072_RS47760_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYFVGSYKE+ RRI+

1

GYFVGSYKEWIVRRIV

16

75.0%

NZ_PGGW01000069.1:

Lassopeptides: CUT44_RS32610_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYF GSYKE+ SRRI+

1

GYFYGSYKEFLSRRIV

16

68.8%

NZ_CP061281.1:

Lassopeptides: IAG42_RS10065_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYFVG YKE+ RRI+

1

GYFVGPYKEWIVRRIV

16

68.8%

NZ_FOSG01000008.1and 1 other:

NZ_PDKQ02000012.1 Lassopeptides: BFM75_RS03245_lassopeptide

Lassopeptides: BM237_RS28735_lassopeptide

1

GYFVGSYKEYWSRRII

16

GYF G YKEY+SRR +

1

GYFFGKYKEYFSRRFV

16

58.8%

NZ_JACHEM010000013.1:

Lassopeptides: HNQ79_RS23595_lassopeptide

1

GYFVGSYKEYWSRRII

16

G F S KEYWSRR+

1

GMFYASCKEYWSRRLC

16

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

Additional weak hits (11):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.15 out of 28.14

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.76 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.98 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.09 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.78 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.51 out of 27.78

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.76 out of 27.04

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.11 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.70 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.90 out of 35.63

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.82 out of 36.53

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

IE135_RS32485 - Class II: Cleavage pHMM score: -1.40; RODEO score: 20; Monoisotopic mass: 2005.0 Da; Molecular weight: 2006.3 Da; Number of bridges: 0

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 0 - 82; Score: 87.4

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_BMSZ01000040.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 4,585 nt. (total: 4,585 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

IE135_RS33325: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IE135_RS33330: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.70	NRPS	enniatin	Fusarium equiseti
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.70	NRPS	enniatin	Fusarium equiseti
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 4585:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS33330: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (446..862): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LAAHFDFSVWEGNQIFGGEVNMYAPTETTVVCTA
Nearest Stachelhaus code(s):: Val DFWNIGMVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

NZ_BMSZ01000041.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 4,528 nt. (total: 4,528 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

IE135_RS33340: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS33345: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.70	NRPS	enniatin	Fusarium equiseti
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.70	NRPS	enniatin	Fusarium equiseti
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 4528:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Lys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS33340: Lys

Search NORINE for peptide: strict or relaxed

AMP-binding (429..784): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FGIAFDVSVFETELSTGGEWNGYGPTETTVAITL
Nearest Stachelhaus code(s):: Lys DVFESGGVAK (97% 8Å match); meSer DVFESGGVAK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

NZ_BMSZ01000046.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 3,222 nt. (total: 3,222 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

IE135_RS33400: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.65	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.65	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 3222:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IE135_RS33400: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (87..482): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDIAGLELQALVGGETNLYGPTETTIWSTA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

NZ_BMSZ01000048.1 - Region 1 - NRPS

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Location: 1 - 3,166 nt. (total: 3,166 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

IE135_RS33420: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IE135_RS35250: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001268.4	0.57	NRPS, PKS	fusarin C	Fusarium fujikuroi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001268.4	0.57	NRPS, PKS	fusarin C	Fusarium fujikuroi

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

IE135_RS33420: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (24..226): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LGTHFDFSVWEGNQVFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor