LOCUS       NZ_BMSZ01000016        22343 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces badius strain JCM 4350 sequence16, whole genome shotgun
            sequence.
ACCESSION   NZ_BMSZ01000016
VERSION     NZ_BMSZ01000016.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces badius
  ORGANISM  Streptomyces badius
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 218287)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 154X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649415.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:57:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,894
            CDSs (total)                      :: 6,825
            Genes (coding)                    :: 6,582
            CDSs (with protein)               :: 6,582
            Genes (RNA)                       :: 69
            rRNAs                             :: 2 (23S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 244
            CDSs (without protein)            :: 243
            Pseudo Genes (ambiguous residues) :: 0 of 244
            Pseudo Genes (frameshifted)       :: 70 of 244
            Pseudo Genes (incomplete)         :: 206 of 244
            Pseudo Genes (internal stop)      :: 7 of 244
            Pseudo Genes (multiple problems)  :: 38 of 244
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:11:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 162473
            Orig. end                         :: 184816
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSZ01000016.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22343
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="deazapurine"
                     /region_number="1"
                     /rules="(GTP_cyclohydroI and PTPS and QueE and QueC and not
                     (dpdA1 or bTGT))"
                     /tool="antismash"
     cand_cluster    1..22343
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /kind="single"
                     /product="deazapurine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22343
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12343](-)"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12343)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
     misc_feature    complement(314..333)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.62"
                     /tool="antismash"
     gene            complement(320..793)
                     /locus_tag="IE135_RS26060"
                     /old_locus_tag="GCM10010253_52760"
     CDS             complement(320..793)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122977.1"
                     /locus_tag="IE135_RS26060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52760"
                     /product="hypothetical protein"
                     /protein_id="WP_069744106.1"
                     /transl_table=11
                     /translation="MVERQETSEDAVMTRIGQAIMLLHGGDREEARNRFGALWSELGAD
                     GDALHRCTLAHYMADTQDDPGDELAWDLRALTAAEGAGGGRSAQHPDLPAVRAFYPSLH
                     LNLAADYLKLQRPDSARIHLQRARVAAASLPDDGYGDGVRAAIDRLELRLRDQ"
     gene            complement(910..1599)
                     /locus_tag="IE135_RS26065"
                     /old_locus_tag="GCM10010253_52770"
     CDS             complement(910..1599)
                     /EC_number="3.2.2.27"
                     /GO_function="GO:0004844 - uracil DNA N-glycosylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607231.1"
                     /locus_tag="IE135_RS26065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52770"
                     /product="uracil-DNA glycosylase"
                     /protein_id="WP_176734681.1"
                     /transl_table=11
                     /translation="MDVTDIDLLPESWRGVLGEELQKPYVKELADFVEEERAKGPVYPP
                     REQVFAALDATPYDKVKVLVLGQDPYHGAGQGHGLCFSVRPGVRTPPSLRNIYKEMQQE
                     LGLPIPDNGYLMPWAEQGVLLLNAVLTVRGGEANSHKNKGWEKITDAVIRAVADRPDPA
                     VFVLWGNYAQKKLPLIDEERHIVVKGAHPSPLSAKKFFGSRPFTQINEAVAAQGHQPID
                     WRIPDLG"
     gene            complement(1698..3278)
                     /locus_tag="IE135_RS26070"
                     /old_locus_tag="GCM10010253_52780"
     CDS             complement(1698..3278)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105163.1"
                     /locus_tag="IE135_RS26070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52780"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_199889275.1"
                     /transl_table=11
                     /translation="MFYRASLQAAAALASLSLLAGCGLLSDSGSETDQKITVGTTSSPS
                     TLDPAAAWDGSWELMRNVYQTLVSFPTGSTSPEPDAAESCKFTDATSMAYRCTLKKNLK
                     FSNGEKLDAEAVKYSIDRIVDIHFKGGPAGMLGSLDRIETKGEDTVVFHLNKSDATFPF
                     ILATPAMSLVAPGDYRKDKIRDDGKVTGSGPYLLESYEGRKTAELKKNPDYNGFAKRKN
                     DAVTIRYFEKSADMVSALKADEIDATYRGLTAEEVVSLEDNKDDNAGLQIVESTGADIR
                     FLVFNPKDPAAANPAVRKAIAHVVDRDALVAKVYRGTAEPLYSMIPKGIAGHTTSFFDT
                     FGDPDADKAKSILSGAGITEPVKMTFWYTTDRYGSATEPEFQELKRQLEASGLFKITLR
                     GEPWQKFQEGFNKGEYPVFGRGWFPDFPDPDNFVAPFVGQEPVTGSPYINKEITQQLIP
                     ASRQESDRGAVSKQFERAQEIMVDDVRLLPLWQGKLYIAAGEDIGGGERALDPQTVMQL
                     WELYRKASW"
     gene            complement(3397..4152)
                     /locus_tag="IE135_RS26075"
                     /old_locus_tag="GCM10010253_52790"
     CDS             complement(3397..4152)
                     /NRPS_PKS="Domain: PKS_KR (8-172). E-value: 1.4e-08. Score:
                     26.8. Matches aSDomain:
                     nrpspksdomains_IE135_RS26075_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010062246.1"
                     /locus_tag="IE135_RS26075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52790"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_065489216.1"
                     /sec_met_domain="adh_short (E-value: 9e-31, bitscore:
                     100.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.5e-33, bitscore:
                     110.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQDSGKVALVTGASRGIGYGIAEALVARGDRVAITGRGEDALK
                     EAVERLGADRVIAIPGKAHDEAHQAAAVERTMEAFGRVDYLVNNAGTNPVFGPMAELDL
                     NVARKVYETNVISALGFAQQTWKAWQKENGGAIVNIASVAGVAPSPFIGAYGMSKAAMI
                     NLTAQLAHEFAPVVRVNAIAPAVVKTKFAEALYEGREAEAAAAYPLGRLGVPEDIGGAA
                     AFLTSAQSDWITGQTLVVDGGIFLNAGVG"
     aSDomain        complement(3637..4128)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE135_RS26075_PKS_KR.1"
                     /evalue="1.40E-08"
                     /label="IE135_RS26075_PKS_KR.1"
                     /locus_tag="IE135_RS26075"
                     /protein_end="172"
                     /protein_start="8"
                     /score="26.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGASRGIGYGIAEALVARGDRVAITGRGEDALKEAVERLGA
                     DRVIAIPGKAHDEAHQAAAVERTMEAFGRVDYLVNNAGTNPVFGPMAELDLNVARKVYE
                     TNVISALGFAQQTWKAWQKENGGAIVNIASVAGVAPSPFIGAYGMSKAAMINLTAQLAH
                     E"
     CDS_motif       complement(4036..4122)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE135_RS26075_0001"
                     /evalue="4.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE135_RS26075"
                     /protein_end="39"
                     /protein_start="10"
                     /score="13.0"
                     /tool="antismash"
                     /translation="LVTGASRGIGYGIAEALVARGDRVAITGR"
     gene            complement(4173..4934)
                     /gene="fabG"
                     /locus_tag="IE135_RS26080"
                     /old_locus_tag="GCM10010253_52800"
     CDS             complement(4173..4934)
                     /EC_number="1.1.1.100"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-167). E-value: 3e-19. Score:
                     61.6. Matches aSDomain:
                     nrpspksdomains_IE135_RS26080_PKS_KR.1"
                     /codon_start=1
                     /gene="fabG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262869.1"
                     /locus_tag="IE135_RS26080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52800"
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="WP_030845946.1"
                     /sec_met_domain="adh_short (E-value: 7.3e-37, bitscore:
                     120.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTEQRVAIVTGAARGIGAATAVRLAAEGRAVAVLDLDEAACKD
                     TVEKITAAGGTALAVGCDVSDAGQVEAAVARVAAELGAPTILVNNAGVLRDNLLFKMSE
                     SDWDIVMNVHLKGAFLMAKAVQAHMVEAKFGRIVSLSSSSALGNRGQANYSAVKAGLQG
                     LTKTLAKELGKFGVTANAVAPGFIVTEMTAQTAERVGMGFEEFQAAAATQIPVQRVGRP
                     EDVANAIAFFAGDNAGFVSGQVMYVAGGPLN"
     aSDomain        complement(4434..4913)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE135_RS26080_PKS_KR.1"
                     /evalue="3.00E-19"
                     /label="IE135_RS26080_PKS_KR.1"
                     /locus_tag="IE135_RS26080"
                     /protein_end="167"
                     /protein_start="7"
                     /score="61.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAIVTGAARGIGAATAVRLAAEGRAVAVLDLDEAACKDTVEKITA
                     AGGTALAVGCDVSDAGQVEAAVARVAAELGAPTILVNNAGVLRDNLLFKMSESDWDIVM
                     NVHLKGAFLMAKAVQAHMVEAKFGRIVSLSSSSALGNRGQANYSAVKAGLQGLTKT"
     CDS_motif       complement(4839..4907)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE135_RS26080_0001"
                     /evalue="1.60E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE135_RS26080"
                     /protein_end="32"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="IVTGAARGIGAATAVRLAAEGRA"
     gene            complement(5174..5557)
                     /locus_tag="IE135_RS26085"
                     /old_locus_tag="GCM10010253_52810"
     CDS             complement(5174..5557)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451004.1"
                     /locus_tag="IE135_RS26085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52810"
                     /product="DUF3037 domain-containing protein"
                     /protein_id="WP_010062244.1"
                     /transl_table=11
                     /translation="MTRRDVFEYALLRVVPRVERGECFNAGVLVYCRAHSFVAARTYLD
                     EAKLKALDPDADVVGVRAALRAVEGVCGGGAEAGQAAGDDAGRRFRWLIAPRSTVVQPG
                     AVHSGLTTDPAGEVERLLDLLVR"
     gene            complement(5554..6435)
                     /locus_tag="IE135_RS26090"
                     /old_locus_tag="GCM10010253_52820"
     CDS             complement(5554..6435)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122983.1"
                     /locus_tag="IE135_RS26090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52820"
                     /product="HipA family kinase"
                     /protein_id="WP_199889276.1"
                     /transl_table=11
                     /translation="MLQEVVATRYVTPLREGGSLPGIVEADDLGTYVMKFTGAGQGRKT
                     LVAEIICGELGRRLGLRVPELVTIELDPVIGLAEPDQEVQELLKASGGLNLGMDYLPGS
                     FGFDPLAYEVGVAEAGRVVWFDALINNVDRSWRNPNLLVWHGDLWLIDHGATMIWHHNW
                     PGAQASAAKPYNASDHVLAPFGPDIAAAAAELAPLVTEELLTEVAADVPDVWLAGEPGF
                     DSADEVRRAYVAPLLARAATIHERITLDAPTAARPSQAPGWLTDRLPPRRKRAADDDRA
                     AAAARTGEEGGR"
     gene            complement(6567..7811)
                     /locus_tag="IE135_RS26095"
                     /old_locus_tag="GCM10010253_52830"
     CDS             complement(6567..7811)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070062.1"
                     /locus_tag="IE135_RS26095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52830"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_069736089.1"
                     /sec_met_domain="ATP-grasp (E-value: 9.4e-10, bitscore:
                     32.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPANESPAVLLLDPVRTGAHYKTEARRRGFSTISVYTVAQEVIAE
                     NWPDHADGDDVSVYSADADEILTRIDSLGVQLIGVVPAMDSAVHLADTLAERLSLPGNG
                     LAKAAARRNKADMRRVAAEAGLRIPRFVLVDSTAKIAAAASEIGFPAIAKHTTGAGSYG
                     TYLLSSPEDAARTSTMHAKNQFGWQVDEWLVEQYIRGRELAVNCFSHNGEHRIVDIWEY
                     RQPDDSDYDFPYWESAKLPEDDPDYQAAADYVRAALTAFDVRLGPSHTEVKVGPDGVHL
                     MEVGARLPGGPMTDQWLAHTDLNPFEQALDCYLGVRPACLDAPVRFRQSCGASAIRNDG
                     PAGTLREIRGLDEVRKMPGVDKVLSIYEPGDHVPITDNTLNIPIGVWVSAPDHAGVVEL
                     LARVRDTVELVIDET"
     gene            complement(7890..8891)
                     /locus_tag="IE135_RS26100"
                     /old_locus_tag="GCM10010253_52840"
     CDS             complement(7890..8891)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (116-304). E-value: 1e-18. Score:
                     60.0. Matches aSDomain:
                     nrpspksdomains_IE135_RS26100_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070063.1"
                     /locus_tag="IE135_RS26100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52840"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_199889277.1"
                     /sec_met_domain="TauD (E-value: 3.5e-18, bitscore: 60.0,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALAVREKHVAQPALRLTRDEAGTLWELSEKSAGLLDPPHSSDLS
                     EFLPDVPAHLRDALLDFREGTASSGYLLVKGVATGDIPDTPLAYGTRALVGHASNGTLA
                     LVGDVLGSLIGYADEKNGDLLHDVHPVRGEEHRMENSGSVAFDFHTENVHHPLRPDFLG
                     LLSLRQGHEATATRVASIRHAVAHLSEDENAVLRRLRFRSLFPTSFTRGLTGERPATAE
                     HRVLFGDPGYEFLRFDSFNTKPADLEAERALGALAEALEAVCVEVVLEPGDLLLVNNHI
                     AAHGRSAFTPRYDGRDRWLRRFYSHRAVPGWARLMMPSKRVLPATGDIQGIF"
     aSDomain        complement(7980..8543)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE135_RS26100_TauD.1"
                     /evalue="1.00E-18"
                     /label="IE135_RS26100_TauD.1"
                     /locus_tag="IE135_RS26100"
                     /protein_end="304"
                     /protein_start="116"
                     /score="60.0"
                     /tool="antismash"
                     /translation="ADEKNGDLLHDVHPVRGEEHRMENSGSVAFDFHTENVHHPLRPDF
                     LGLLSLRQGHEATATRVASIRHAVAHLSEDENAVLRRLRFRSLFPTSFTRGLTGERPAT
                     AEHRVLFGDPGYEFLRFDSFNTKPADLEAERALGALAEALEAVCVEVVLEPGDLLLVNN
                     HIAAHGRSAFTPRYDGRDRWLRRFY"
     gene            complement(8906..9937)
                     /locus_tag="IE135_RS26105"
                     /old_locus_tag="GCM10010253_52850"
     CDS             complement(8906..9937)
                     /EC_number="1.14.19.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016717 - oxidoreductase activity, acting
                     on paired donors, with oxidation of a pair of donors
                     resulting in the reduction of molecular oxygen to two
                     molecules of water [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070064.1"
                     /locus_tag="IE135_RS26105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52850"
                     /product="fatty acid desaturase family protein"
                     /protein_id="WP_234428067.1"
                     /transl_table=11
                     /translation="MSEKDQLTVRPYAKGYTAPSRLRLDIKDAHRTRLWVTTSCALLDH
                     LVVGLMAAGAAWLIVNHPLASIVPALLAGVVIARQLRALENLVHEASHYNWSRHRRRLN
                     DVLGYLLAAAPTGSRISAYRTSHLLHHGRFGTAEDPDRYRYAELDMEALPRTSARLFVA
                     GVCTRLLRYQLGWLRELRTNALAPLVALLWSVLCVGAPTALLLDLRTGAVAAGVWLFAH
                     FLLLPPLRLVAEADEHVYSDARTVFDATVSNTGRLQRWLFHPHADGYHTVHHMWPGIPH
                     HSLSRIHHLLLSEDEEFARRLRTRDRILTTPGGVAPGGPAREAATPREPTSPPPSLKIK
                     SSL"
     gene            complement(10001..10600)
                     /gene="folE"
                     /locus_tag="IE135_RS26110"
                     /old_locus_tag="GCM10010253_52860"
     CDS             complement(10001..10600)
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: GTP_cyclohydroI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070065.1"
                     /locus_tag="IE135_RS26110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52860"
                     /product="GTP cyclohydrolase I"
                     /protein_id="WP_234428068.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 1.6e-52,
                     bitscore: 171.1, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIDMDASAITILEQDEVQGGDPLESIARRLLIEIGEDPDREGLR
                     DTPRRYARWWREFVDYDAGNLDTVFSSVASNQTVMVSGMRVWSLCEHHLLPFNCDLQVA
                     YRAHDSLLGLSKFARIAHKHAHKLQVQERLVADIAAEIEEITKSPDVAVIGRGEHLCMT
                     MRGIKTGAQMTSAVFRGVFRENSFERTELLSLMNGS"
     gene            complement(10601..11308)
                     /locus_tag="IE135_RS26115"
                     /old_locus_tag="GCM10010253_52870"
     CDS             complement(10601..11308)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070066.1"
                     /locus_tag="IE135_RS26115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52870"
                     /product="7-carboxy-7-deazaguanine synthase QueE"
                     /protein_id="WP_234428069.1"
                     /sec_met_domain="QueE (E-value: 3.9e-81, bitscore: 265.7,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.3e-13, bitscore: 44.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.2e-13, bitscore: 45.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIVVNEIFGPTVQGEGPSAGRQCAFLRLGGCNLSCHWCDTPYTW
                     DWKGTSDEKTAFDPRKELHNRDVDEVVDELLALGTDLVVISGGEPLSQQRRLRPVLKRL
                     LDAGVTVEFETNGTVAPDDEIITPGVRFNVSPKLAHAGDPASKRIVPAALSKLAQTPDV
                     AFKFVCRTTDDLDEVAALQADFGISPIWIMPEGKSVAHISQHLSSLADEVVRRGWNLST
                     RLHVLAWGDKRGI"
     gene            complement(11305..11667)
                     /gene="queD"
                     /locus_tag="IE135_RS26120"
                     /old_locus_tag="GCM10010253_52880"
     CDS             complement(11305..11667)
                     /EC_number="4.1.2.50"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: PTPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070067.1"
                     /locus_tag="IE135_RS26120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52880"
                     /product="6-carboxytetrahydropterin synthase QueD"
                     /protein_id="WP_010070067.1"
                     /sec_met_domain="PTPS (E-value: 3.4e-35, bitscore: 114.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLHITKEFHFSASHRLEHLPSDHQCARLHGHNYIIELKLSAAPDQ
                     LTEPGFVRDYGDLADFKKWLDHTLDHRHLNDIIEDRNPSAENMAMWIYDQWTERYPELS
                     AVRVSETDKTWAEYRP"
     gene            complement(11672..12343)
                     /gene="queC"
                     /locus_tag="IE135_RS26125"
                     /old_locus_tag="GCM10010253_52890"
     CDS             complement(11672..12343)
                     /EC_number="6.3.4.20"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070068.1"
                     /locus_tag="IE135_RS26125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52890"
                     /product="7-cyano-7-deazaguanine synthase QueC"
                     /protein_id="WP_069736088.1"
                     /sec_met_domain="Asn_synthase (E-value: 6.4e-10, bitscore:
                     32.8, seeds: 78, tool: rule-based-clusters)"
                     /sec_met_domain="QueC (E-value: 1.1e-58, bitscore: 191.8,
                     seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARVIAIVSGGLDSVVLAHHLHAEGHEVHLLSIDYGQRHRKEHDY
                     ARIAADRIGAEHEIVDLSNVASMLPGYSLTDSQVDVPDQHYTAPGSVNVVPNRNVILLS
                     VAYGKAAAVKADQVAIGALAGDASTAPDCSAEFISSFNAMEKIACAGYAPAHLEVVAPF
                     IDLHKHDVIRLGEKLGVDWAETWSCFKGTEVHCGTCAACVDRIQAFERAETTDPTVYFK
                     E"
     gene            complement(12576..13589)
                     /locus_tag="IE135_RS26130"
                     /old_locus_tag="GCM10010253_52900"
     CDS             complement(12576..13589)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019356274.1"
                     /locus_tag="IE135_RS26130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52900"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_234428070.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.3e-11, bitscore:
                     37.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.5e-07,
                     bitscore: 24.7, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGVLCYDEIRVPIAARMAEELKLPTANAEGVLACRDKHLGRQAL
                     AAAGVAQPVSRAVASLEEAREAAGAIGYPVVLKPRALAASVGVVRADGPEALDSAYSEA
                     AAAYFDEIPRDRAWVLVEEYLDGPEVSVESVCHNGRVTPMFVALKALGFAPHFEEVGHT
                     VSADDPLLHDPEVRRVLQEAHTALGLDTLVTHTELRLTRTGPRLVEVNARLGGDLIPYA
                     ARLATGVDYGMVAADLAAGGRPDVAPVRTASAHVEFLYPEHDLDVTSLTVEEELPAGVH
                     EVTPMAEPGRRLRLPPRDHVAGRYAYVVTTGVSPQECADALRAATPLVRLAGTPVD"
     misc_feature    13738..13753
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.1"
                     /tool="antismash"
     misc_feature    complement(13853..13863)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(13873..13884)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.92"
                     /tool="antismash"
     gene            complement(14030..15022)
                     /locus_tag="IE135_RS26135"
                     /old_locus_tag="GCM10010253_52910"
     CDS             complement(14030..15022)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122992.1"
                     /locus_tag="IE135_RS26135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52910"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_234428071.1"
                     /transl_table=11
                     /translation="MDMHLSTDMRRAYALAVRRRALTAEVVADELGLDASEADRVIAGL
                     VELRLLQQDAGGDLFAAVAPDSAQLRLLGPLVREISVMQEKADRIRADLGSLLPVYWDE
                     VESAAGQIEVVRDLDVVLTLIEEFSARATTEVLTSQPGGGRPVKQLETALTFAQELLER
                     GVRMRTLYQHTAQFHQGTAAYVEHVAPLGGEVRTTASGFPRMLVFDRRVAVLALKGHPE
                     GALVLRNENVIDVLVDTFERTWVGARPFPLSYSKGQIVHVSSEVKDTIMRLLVVGESDK
                     KIAARVGLSLRTCQRHIADLMQEIGARNRLHAGYLLHEQLAKSDAGGVT"
     misc_feature    15391..15406
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     misc_feature    complement(15410..15425)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.16"
                     /tool="antismash"
     gene            15521..15700
                     /locus_tag="IE135_RS26140"
                     /old_locus_tag="GCM10010253_52920"
     CDS             15521..15700
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122994.1"
                     /locus_tag="IE135_RS26140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52920"
                     /product="hypothetical protein"
                     /protein_id="WP_069736086.1"
                     /transl_table=11
                     /translation="MRLVTEILKSSLLAATLLGLAGPTIDASNRSTQADTRANSASCGH
                     ACPNNAPGADLGWG"
     gene            15820..17067
                     /locus_tag="IE135_RS26145"
                     /old_locus_tag="GCM10010253_52930"
     CDS             15820..17067
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122995.1"
                     /locus_tag="IE135_RS26145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52930"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_069736085.1"
                     /sec_met_domain="ATP-grasp (E-value: 7.4e-08, bitscore:
                     25.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.5e-12, bitscore:
                     41.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLHTRRRPVGSVLLLGGTRPEPVRAAKAAGLSITYLGAAARTPRD
                     ILDNADGCLLLEDPTPENMTEAARKLHAEKSFGVVVTMVDRYLEAAALLNAEFGLPANT
                     VDTVRSMNDKHRMRAAALHSACAPVAHAAVRTAEDLRSFAGRHGYPFILKPVDGSASRG
                     VALVSDAGTLESAARAMTGSAAPESRWIAEEFLSGPEFSVETFSTDGSHHVVAVTEKFK
                     GDNFVEIGHLVPARVRAADHAAMAAEVGALLDAVGLNEGVAHTEVVLTDAGPRVVETHS
                     RPGGDGIVELVRLAKGVDLQQMTFDWFAGKPVDPLLAPAARASATWSLTPPEGTVTAVS
                     GLDEALRHEGVTEGYTVLEPGDTVRPLRSSDDRSGAVITVAPGPDAALARARAAVDLID
                     VTVVPAGADLGGPVPR"
     gene            17064..18293
                     /locus_tag="IE135_RS26150"
                     /old_locus_tag="GCM10010253_52940"
     CDS             17064..18293
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122996.1"
                     /locus_tag="IE135_RS26150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52940"
                     /product="MFS transporter"
                     /protein_id="WP_069736084.1"
                     /transl_table=11
                     /translation="MSGERSYGYRVLFSEPGILVYALAAAFGKLQAGMFALGTLYAVAD
                     QRSYSAGAFVVAVSALGGLSTPLRGRLLDRYSYGPVLWTIMAIHTVLVGGLLVNEHRGG
                     PFWVTVASGLLGNLAAPPIGVVTRVMWRSVTTEKSRPTALAFDSVLADAGFILGPALAA
                     LVCATLAPWAGLAAVLFFTAVAMLLLPKNIGDDKTSARQGDRHWAGPLTSPRLVLLLGA
                     ALCFATSVSVLEIALATPHGDGDSKVLSGLLVSVLATGSIVGGLLIGAMTPELAKRATR
                     LPVLLMSLAVFSTALAFGNKAGWLVAVPLCLLTGLSFGPSFVAVYGRSGDLAPAGMAAE
                     TQAWAGTALQLGSAAGAGAGGVLLDIWGPPGALALAPMAAVIGAASAFAGDRLRTPVAE
                     PRGDAIPESL"
     gene            complement(18441..19139)
                     /locus_tag="IE135_RS26155"
                     /old_locus_tag="GCM10010253_52950"
     CDS             complement(18441..19139)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123000.1"
                     /locus_tag="IE135_RS26155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52950"
                     /product="B3/4 domain-containing protein"
                     /protein_id="WP_199889279.1"
                     /transl_table=11
                     /translation="MTFQLTVADEVYTLAPTFTHVAIEAYDLVNGPSSEESSAFLDEAA
                     RRLAVRLDGRAPHEDPHVTSWRETYTAFGSKPSRTRNSAEALAKRALSDAGLPRINLLV
                     DLYNAISVAHLIPVGGEDLDLIEGGMRLVRAEGDEDFVTVTGGERTVEHPDAGEVVWCD
                     DAGVTCRRWNWRQGPRTRLTEETTSGLFLLEGLAPMPVAELETAAAELAEALAKFSPSA
                     RIEVHAPVSA"
     gene            19414..20415
                     /locus_tag="IE135_RS26160"
                     /old_locus_tag="GCM10010253_52960"
     CDS             19414..20415
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070090.1"
                     /locus_tag="IE135_RS26160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52960"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_199889280.1"
                     /transl_table=11
                     /translation="MLRIHFTPEDLTRVRVAPGPDFLWEITNSVQTLQRTDGERVFGTW
                     RRWVRPRLPESRRLLSPLLPPRGYSPDFLTPTSGDRTTLRAAVDTLLGTPRPRLRAELS
                     RLAGTRRLPGRAAALAEGDPDALARLGKALHAYQAEVLVPHWRHVRAALEADRALRTRH
                     LMDGGTEALLAGLGPDVRWRPPVLEVTYPVEQHLRLNGRGLVLQPSFFCWPTPTTLADG
                     DLPPVLVHPIRHSADWAEGAAAPERAAGPNPLGRLLGQTRADLLRATRAGCSTMEAARM
                     LQVTHPAVSQHMNVLRAAGLTTTVRTAGRAFHVATAEGRALLAAEDRRAGRG"
     gene            20569..21282
                     /locus_tag="IE135_RS26165"
                     /old_locus_tag="GCM10010253_52970"
     CDS             20569..21282
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468596.1"
                     /locus_tag="IE135_RS26165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52970"
                     /product="C39 family peptidase"
                     /protein_id="WP_199889281.1"
                     /transl_table=11
                     /translation="MRPRLVPGTIAALAIGALLLPGTAEASPAPAVPVVDVRAHDSTSG
                     TALASGYGKPGTRLRVDAGRSSNARWLEIDYQVQQTGYWCGPAATRIALSARTAAPSQG
                     ELAAQLGTTEAGTDHIGQITAVLNARLGSGWYETKEMPNDPPTQAQRDLLWHDIVFDID
                     RNYPLVANIVAPPGNQPPGYPPDQTIYHYFTVFGYDAVDRTVLIADPASFGGNQIYWIS
                     FDQLATLIPPKGYSA"
     gene            21330..22319
                     /locus_tag="IE135_RS26170"
                     /old_locus_tag="GCM10010253_52980"
     CDS             21330..22319
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468390.1"
                     /locus_tag="IE135_RS26170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010253_52980"
                     /product="alpha/beta hydrolase family protein"
                     /protein_id="WP_128817008.1"
                     /transl_table=11
                     /translation="MSTQRPTRRGVLKAAAGISATTALGAGGVLASASAAHAVGDGFGL
                     RIVDRDERDPRMRYFRFATDAIGWNPGVNVLLPDGYHSGGRRYPVLYLFHGGGTGQDFI
                     TFDRMGIRAWTAGKPLIVVMPDGGAAGWYSNPVVSNVGPRNWETFHIGQLLPWVDANFR
                     TYAEYDGRAVSGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDAGLVTHWANLSSA
                     AVELGGGTVYGAPLWDEARVSADNPVQRVGSYRNKRVFLVAGTSPDPVNWFDTVNETQV
                     LAGQREFRGTLGAAGIPHEFHEVPGGHFVRPDLFRRDLDGIVARLRKA"
ORIGIN
        1 ggccgccgcc cgaccggccg tcctcccccg cgcccccggc cgtcggctcc gcggaggccc
       61 ggcgcggcgg accggcgggg gtcacccggc cgcccgagcg cgcggaccgg ccgcagcgac
      121 gggcccccga ccgggccccg agggtcccgt ccgtcaccgt gcccgccctg ccacgcgtcc
      181 ccggcggcgg tgcggacgtc tgtgcgctcg gccgggggta cggcggctgg cccgcgggca
      241 gcccgcaggc ccgcatctgc tcggagacgt acggccactg acgctgctgc ccccggaggc
      301 cctgcggggt ccccgggggt cactggtccc gcaggcggag ctccaggcgg tcgatggcgg
      361 cgcggacccc gtcgccgtac ccgtcgtccg ggagcgatgc ggcggcgacg cgggctcgtt
      421 ggaggtggat gcgggcggag tcggggcgct ggagcttgag gtagtccgcc gcgaggttga
      481 ggtgcagcga ggggtagaac gcccggacgg ccggaaggtc cgggtgctgc gccgaccgcc
      541 caccgcccgc cccctcggca gccgtcaggg cccgcaggtc ccaggccagc tcgtcgccgg
      601 ggtcgtcctg ggtgtcggcc atgtagtgcg cgagggtgca gcggtgcagg gcgtcgccgt
      661 ccgctccgag ctccgaccag agcgcaccga agcggttgcg ggcctcctcc cggtcacctc
      721 cgtggagcag catgatcgcc tggccgatcc tggtcatgac ggcgtcctcg gacgtctcct
      781 gccgctccac cactgctgtc tcctcgtcgc ccgtccaacc ggtcgcccct gtccgtccga
      841 cgctaacggc aggcttgcgc agaaccggtc agacacgggc gcggcgggtg cccctgccgg
      901 gggaacccgt cagccgaggt cggggatccg ccagtcgatc ggctggtgcc cctgggcggc
      961 cacggcctcg ttgatctgcg tgaaggggcg ggagccgaag aacttcttgg cggacagcgg
     1021 cgaggggtgt gcgcccttca ccacgatgtg gcgctcctcg tcgatcaagg gcagcttctt
     1081 ctgcgcgtaa ttgccccaga gcacgaagac cgccggatcg ggccggtccg cgacggcgcg
     1141 gatcacggcg tcggtgatct tctcccagcc cttgttcttg tgggagttgg cctcgccgcc
     1201 ccggacggtc agcacggcgt tgagcaggag cacgccctgt tcggcccagg gcatcagata
     1261 gccgttgtcc gggatgggca ggcccagctc ctgctgcatc tccttgtaga tgttgcgcag
     1321 ggacggcggc gtcctgacgc cgggccgcac ggagaagcag agcccgtgcc cctggcccgc
     1381 gccgtgatac gggtcctggc cgaggacgag gaccttcacc ttgtcgtaag gcgtggcgtc
     1441 cagcgcggcg aagacctgct cgcggggcgg gtacacggga cccttggccc gctcctcctc
     1501 gacgaagtcc gccagctcct tgacgtacgg cttctgcagt tcttcgccga ggacgccgcg
     1561 ccaggactcg ggcagcaggt cgatatcggt cacgtccaca acctccggtg agcaacaggt
     1621 tcttggtccc agaacctacc ggtcaccact gacaacgggc ccccgaggag gcccgtcgtc
     1681 ccttcatcgc cggtctgcta ccagctggcc ttgcggtaca gctcccacag ctgcatgacc
     1741 gtctgcgggt cgagtgcccg ctcgccgccg ccgatgtcct cgcccgcggc gatgtacagc
     1801 ttgccctgcc acagcggcag caggcggacg tcgtcgacca tgatctcctg ggcccgctcg
     1861 aactgcttgc tgaccgcgcc ccggtcgctc tcctgccgcg aggcggggat cagctgctgg
     1921 gtgatctcct tgttgatgta cgggctgccg gtgacgggct cctggcccac gaacggggcg
     1981 acgaagttgt cggggtccgg gaagtcgggg aaccagccgc ggccgaagac cgggtactcg
     2041 cccttgttga agccttcctg gaacttctgc cagggctcgc cccgcagcgt gattttgaac
     2101 agtccggagg cctccagctg ccgcttgagc tcctggaact cgggctccgt ggcggagccg
     2161 tagcggtcgg tggtgtacca gaaggtcatc ttcacgggct cggtgatgcc tgccccggag
     2221 aggatgctct tcgccttgtc cgcatccggg tcgccgaagg tgtcgaagaa gctcgtggtg
     2281 tgtccggcga tgcccttggg gatcatggag tagaggggct cggcggtgcc ccggtagacc
     2341 ttggcgacca gcgcgtcgcg gtccacgaca tgggcgatgg ccttgcggac ggcggggttc
     2401 gcggcggccg ggtccttcgg gttgaagacc aggaagcgga tgtccgcgcc cgtgctctcg
     2461 acgatctgga ggccggcgtt gtcgtccttg ttgtcctcca ggctgacgac ctcctcggcg
     2521 gtcagaccgc ggtaggtggc gtcgatctcg tcggccttga gcgcgctcac catgtccgcg
     2581 gacttctcga agtagcggat ggtgaccgcg tcgttcttcc gcttggcgaa gccgttgtag
     2641 tccgggttct tcttcagctc ggcggtcttc cggccctcgt aggactccag gaggtacggg
     2701 ccggagccgg tgaccttgcc gtcgtcgcgg atcttgtcct tgcggtagtc gccgggggcg
     2761 acgagcgaca tggcgggcgt ggccaggatg aacgggaacg tggcgtcgga cttgttcagg
     2821 tggaagacga ccgtgtcctc gcccttggtc tcgatccggt ccagcgagcc gagcatcccg
     2881 gccgggccgc ccttgaagtg gatgtccacg atgcggtcga tggagtactt cacggcctcg
     2941 gcgtcgagct tctcgccgtt ggagaacttg aggttcttct tgagcgtgca ccggtacgcc
     3001 atgctcgtgg cgtcggtgaa cttgcaggat tccgccgcgt caggctccgg gctcgtgctg
     3061 ccggtgggga agctcaccag ggtctggtaa acgttccgca tcaattccca ggatccgtcc
     3121 caggccgccg ccggatcgag cgtggacggg gaactggtcg taccgacggt tatcttctgg
     3181 tccgtttccg atccgctgtc ggaaaggaga ccgcagccgg ccagcagaga aagggaagct
     3241 agggctgcag cagcctgcag actggcccgg tagaacacgt gcacgctcct cgatcagcca
     3301 tgggtcggca gaccataccg cagcgcccca ccaggtcaat ccggtggccc ggcggggcac
     3361 ttgactcaat cagggccaaa tcggttcagg ccgctctcag cccacaccag cgttgaggaa
     3421 aattcctccg tcgaccacga gggtctgtcc ggtgatccag tcggactgtg ccgaggtcag
     3481 gaaggcggcc gcgcctccga tgtcctcggg cacgccgagc cggcccagcg gataggcggc
     3541 ggccgcctcc gcctcgcggc cctcgtagag cgcctcggcg aacttcgtct tgaccacggc
     3601 cggggcgatc gcgttgaccc ggacgaccgg ggcgaactcg tgcgccagct gggcggtcag
     3661 gttgatcatg gccgccttcg acatgccgta cgcgccgatg aacggcgagg gggcgacgcc
     3721 ggcgacggag gcgatgttga cgatcgcccc gccgttctcc ttctgccagg ccttccaggt
     3781 ctgctgggcg aagccgagcg ccgagatcac attggtctcg tagaccttgc gggccacatt
     3841 gaggtcgagt tcggccatcg ggccgaagac cgggttggtc cccgcgttgt tcaccaggta
     3901 gtcgacccgg ccgaacgcct ccatggtccg ctcgaccgcc gccgcctgat gggcctcgtc
     3961 gtgcgccttg ccggggatcg cgatgacccg gtcggcgccg agccgctcca cggcctcctt
     4021 gagggcgtcc tcgccccgcc cggtgatggc gacccggtcc ccgcgggcga cgagcgcctc
     4081 ggcgatcccg tagccgatgc cccggctggc gcccgtgacg agggcgacct ttccgctgtc
     4141 ctgcaccgtc atgttgtccg ctgcccttcg gatcagttga ggggtccgcc ggccacgtac
     4201 atgacctggc cggagacgaa gcccgcgttg tcgcccgcga agaaggcgat ggcgttcgcg
     4261 acgtcctcgg gacggccgac gcgctggacg gggatctggg tggcggccgc cgcctggaac
     4321 tcctcgaagc ccatgccgac gcgctcggcg gtctgcgcgg tcatctcggt gacgatgaat
     4381 ccgggcgcga cggcgttggc ggtgacgccg aacttgccga gctccttggc gagggtcttg
     4441 gtgaggccct ggaggcccgc cttgaccgcg gagtagttgg cctggccccg gttgccgagg
     4501 gccgaggagg aggagagcga gacgatccgg ccgaacttgg cctcgaccat gtgggcctgg
     4561 acggccttcg ccatcaggaa cgcgcccttg aggtgcacgt tcatcacgat gtcccagtcg
     4621 gactcgctca tcttgaacag caggttgtca cggagcacgc cggcgttgtt cacgaggatc
     4681 gtcggcgcgc ccagctcggc ggcgacccgc gcgacggcgg cctccacctg accggcgtcc
     4741 gacacgtcgc agccgacggc cagcgcggtg cccccggcgg cggtgatctt ctcgaccgtg
     4801 tccttgcagg ccgcctcgtc gagatcgagt acggcgacgg cgcggccctc ggccgcgagg
     4861 cgtacggcgg tggcggcgcc gatgccccgc gccgctcccg tcacgatggc gacgcgctgc
     4921 tcggtggtgg acatgcttgg ttctcctcgc ccttggatag cggcccagcc gacatcgggg
     4981 cacttccccg ccagtccctg acactccctg gcagcaagac cctcgattgc tgagcaaccg
     5041 cttagtacct tcagcagacg tgacgctaga agccctggca cccggtgtca acggcgcacg
     5101 ccccggcggg ccgtacgtca caccgggcgg gagcgtccgc cgctgtgccg tcgtggtccc
     5161 accggggcgc ggatcagcgc acgaggaggt cgagcagccg ttccacctca ccggccgggt
     5221 cggtggtcag cccgctgtgc acggccccgg gctggaccac cgtggagcgc ggggcgatca
     5281 gccagcggaa ccgccgtccg gcgtcgtcgc ccgccgcctg gcccgcctcc gcaccgccgc
     5341 cgcagacccc ttcgacggcg cgcagagcgg cccgcacccc gaccacgtcg gcgtccgggt
     5401 ccagcgcctt cagcttcgcc tcgtcgaggt acgtccgggc cgccacgaac gagtgggccc
     5461 ggcagtagac gagcaccccg gcgttgaagc actccccccg ctcgacccgg ggcacgacgc
     5521 gcaggagcgc gtactcgaag acatcgcgcc gcgtcatcgg ccgccctcct cgccggtacg
     5581 ggcggccgcc gcggcgcggt cgtcgtccgc ggcccgcttc cgccggggcg gcagccggtc
     5641 cgtgagccag cccggggcct gggagggccg ggccgcggtg ggcgcgtcca gtgtgatccg
     5701 ctcgtggatg gtcgcggccc gcgcgagcag cggggcgaca taggcccggc gcacctcgtc
     5761 ggcggagtcg aaaccgggct cgccggccag ccagacgtcc ggcacatcgg cggcgacctc
     5821 ggtgagcagc tcctcggtga ccagcggggc gagctcggcg gcggcggccg cgatgtcggg
     5881 cccgaagggg gccaggacat ggtcggaggc gttgtacggc ttggcggcgg aggcctgggc
     5941 gcccggccag ttgtggtgcc agatcatggt cgcgccgtgg tcgatcagcc agaggtcgcc
     6001 gtgccagacg agcaggttgg ggttgcgcca ggaacggtcc acgttgttga tcagcgcgtc
     6061 gaaccagacg acccgcccgg cctcggccac cccgacctcg taggcgagcg gatcgaaccc
     6121 gaacgagccc ggcaggtagt ccatgccgag attcagaccg ccgctcgcct tgagcagctc
     6181 ctgcacctcc tggtccggct ccgccagtcc gatgaccggg tccagctcga tggtcaccag
     6241 ctccggcacc cgcagcccga gccggcggcc gagctccccg cagatgatct cggcgacgag
     6301 ggtcttgcgg ccctgtccgg ccccggtgaa cttcatgacg tacgtaccga gatcgtcggc
     6361 ctcgacgatg ccggggagcg agccgccctc acgcagaggc gtgacatagc gggtcgctac
     6421 gacctcttgc aacactttcc cgtcccttgc tgcccgcttc cggcatgaag tgagcatagt
     6481 aaccgggggt gatcgcaggc gaggatcgcc tcgtcctccg cgggtggacg aggcgatccc
     6541 gcgtcggccg gtcgaccggc tcgttctcag gtttcgtcga tgaccagctc gaccgtgtcc
     6601 cggacgcggg cgagcagctc caccacgccc gcgtggtccg gagcggacac ccagactccg
     6661 atcgggatgt tgagggtgtt gtcggtgatc ggcacgtggt cccccggctc gtagatcgac
     6721 agcaccttgt cgacacccgg catcttccgg acctcgtcga ggccacggat ctcccggagg
     6781 gtgcccgccg gaccgtcgtt gcggatggcg ctggcaccgc aggactgccg gaagcgcacg
     6841 ggcgcgtcca gacaggcggg ccggacaccg aggtagcagt cgagtgcctg ctcgaacggg
     6901 ttcaggtcgg tgtgcgcgag ccactggtcc gtcatcgggc caccgggaag ccgcgcgccg
     6961 acctccatga gatgcacgcc gtcggggccg accttcacct cggtgtggct ggggcccagc
     7021 cgcacgtcga acgccgtgag agcggcgcgt acgtagtcgg cggcggcctg gtagtccgga
     7081 tcgtcctcgg gcagcttggc cgactcccag tacgggaagt cgtagtcgct gtcgtcgggc
     7141 tgccggtatt cccagatgtc gacgatgcgg tgctcgccgt tgtggctgaa gcagttcacc
     7201 gccagctcgc gcccgcggat gtactgctcg acgagccact cgtcgacctg ccagccgaac
     7261 tggttcttcg cgtgcatcgt ggatgtccgg gccgcgtcct cggggctgct cagcaggtac
     7321 gtgccgtacg agccggcccc cgtggtgtgc ttggcgatgg ccggaaagcc gatctccgag
     7381 gcggccgcgg cgatcttggc ggtgctgtcc acgagaacga accgcgggat gcgcaggccg
     7441 gcttcggccg cgacccggcg catgtccgcc ttgttccggc gcgcggccgc cttggcgagg
     7501 ccgttgccgg gcagcgacag ccgctccgcc agggtgtcgg ccaggtgcac cgccgagtcc
     7561 atggccggga ccacaccgat gagttgcaca ccgagcgagt cgatccgggt gaggatctcg
     7621 tcggcgtcgg ctgagtagac gctgacgtcg tcgccgtccg cgtgatcggg ccagttctcc
     7681 gcgatcacct cctgggccac cgtgtacacg gagatcgtcg agaagccgcg ccggcgtgcc
     7741 tcggtcttgt aatgggcacc ggtacggacc gggtccagaa gcagaacggc tggcgattca
     7801 ttggcaggca tgagtggggc gaactcctgt gaggcagagg aaggttcggc gggtgggcgc
     7861 ccgcctgcgg tgatggggcg gccggcgggt cagaagatgc cctggatgtc ccccgtcgcg
     7921 ggcaggaccc gcttgctcgg catcatcaga cgcgcccagc ccggcaccgc acgatgcgag
     7981 tagaagcggc gcagccagcg gtcgcgcccg tcgtagcggg gggtgaaggc ggaccgcccg
     8041 tgggccgcga tgtggttgtt gacgagcagc aggtcaccgg gctccaggac gacctcgacg
     8101 cagacggcct ccagggcctc ggccagtgcc cccagggccc gctcggcctc gaggtcggcc
     8161 ggcttggtgt tgaacgagtc gaaacggagg aactcgtagc cgggatcgcc gaagaggacc
     8221 cggtgctccg ccgtcgcggg ccgctcgccg gtcaggcccc gggtgaacga ggtcgggaac
     8281 aggctccgga accgcagccg tcgcagcacg gcgttctcgt cctcggacag gtgggccacg
     8341 gcgtgcctga tggaggcgac gcgggtcgcc gtggcttcgt gcccctgccg caggctcagc
     8401 agtccgagga aatccggccg cagggggtgg tggacgttct cggtgtggaa gtcgaaggcg
     8461 acggagccgc tgttctccat ccggtgctcc tccccgcgca ccgggtgcac gtcgtggagg
     8521 aggtcgccgt tcttctcgtc ggcgtagccg atgagactgc ccagtacgtc ccccaccagg
     8581 gcgagcgtgc cgttgctggc gtgtccgacg agcgcccgcg tcccgtaggc gagtggtgtg
     8641 tcggggatgt cgccggtggc cacccccttg acgagcaggt atccgctgct cgccgtgccc
     8701 tcgcggaaat ccagcagtgc gtcgcgcagg tgagcgggga catcggggag gaactccgac
     8761 agatcggagg agtgcggggg gtcaagaagc ccggccgact tctccgacag ctcccacagg
     8821 gtccccgcct cgtcccgcgt gagccggagg gcgggctgtg ccacgtgctt ttcccgtacg
     8881 gcgagtgcca cgtctgctcc ttgactcaca gagaactctt gatcttgagg gatgggggcg
     8941 gggacgtggg ctcgcgaggc gtggcggcct cgcgggccgg tccgcccgga gccactcctc
     9001 caggcgttgt caggatcctg tcccgtgtcc gcagccgccg ggcgaactcc tcgtcctcgg
     9061 acagcaggag gtggtggatc cgggacagcg agtggtgcgg gatgccgggc cacatgtggt
     9121 gaacggtgtg gtagccgtcc gcgtgcgggt ggaagagcca gcgctggaga cgcccggtgt
     9181 tcgacaccgt ggcgtcgaac accgtacggg cgtcggagta cacgtgctcg tcggcctccg
     9241 cgaccagtcg cagcggcggc agcagcagga agtgcgcgaa gagccagacc ccggccgcga
     9301 cggcgccggt gcgcaggtcc agcagaaggg cggtgggcgc ccccacgcac aggacgctcc
     9361 acagcagtgc cacgagcgga gccagggcgt tggtgcgcag ctcccgaagc cagcccagct
     9421 ggtagcgcag cagccgggtg cacacgccgg cgacgaagag cctcgccgag gtgcggggaa
     9481 gtgcctccat gtcgagctcg gcgtaacggt atctgtcagg atcctcggcc gtaccgaacc
     9541 ggccgtggtg aagcagatgg ctggtccggt acgcgctgat ccggctcccc gtgggggcgg
     9601 cggcgaggag atagcccagg acgtcgttca agcgccgccg gtgcctgctc cagttgtagt
     9661 gggaggcttc atggacgagg ttctccaggg cccgcagctg gcgggcgatg accaccccgg
     9721 cgagcagcgc cgggacgatc gaggcgagcg ggtggttgac gatgagccag gccgcgccgg
     9781 ccgccatcag gccgacgacc aggtgatcca gcagtgcgca ggaagtggtg acccaaagac
     9841 gcgtcctgtg cgcgtccttg atgtccaggc gaagccgcga gggggcggtg taccccttcg
     9901 catagggcct gaccgtgagt tggtccttct ccgacacggg catcagcatc tctccgacaa
     9961 cgatgaacgg ttaccgagct ggtcgtgagc ggtgcacggt tcaggagccg ttcatcaggc
    10021 tgaggagttc ggtccgctcg aagctgttct cgcggaagac gccccggaag acggcggagg
    10081 tcatctgcgc ccccgtcttg atgccgcgca tcgtcatgca caggtgctct ccgcggccga
    10141 tgacggccac gtcgggcgac ttggtgatct cctcgatctc ggccgcgatg tcggcgacga
    10201 ggcgttcctg cacctggagc ttgtgagcgt gcttgtgggc gatccgggcg aacttcgaca
    10261 gcccgaggag gctgtcgtgg gcccggtagg caacctggag gtcgcagttg aagggcagga
    10321 ggtggtgctc gcagagcgac cagacgcgca tgccggagac catgacggtc tggttgctgg
    10381 cgacactgct gaagacggtg tcgaggtttc cggcgtcgta gtcgacgaac tcgcgccacc
    10441 aacgcgcgta gcgccggggg gtgtcgcgca ggccctcgcg gtccgggtcc tccccgatct
    10501 cgatcaggag gcgccgggct atggactcga gcgggtcgcc tccctgcacc tcgtcctgtt
    10561 ccaggatggt gatggcggaa gcgtccatgt cgatgctcat ttagattcct ctcttgtcgc
    10621 cccaggccag gacgtgcagg cgggtggaga gattccagcc acgccgcacg acctcgtccg
    10681 cgagggaact caagtgctga ctgatgtgtg ccacgctctt gccctcaggc atgatccaga
    10741 tcggggagat cccgaagtcc gcctgcaggg cagctacttc gtccaggtcg tcggtggtgc
    10801 ggcagacgaa cttgaacgcc acgtcggggg tctgcgccag cttgctcagg gcagcgggca
    10861 cgatccgctt ggacgcgggg tccccggcgt gggcaagctt cggggagacg ttgaagcgca
    10921 ctccgggtgt gatgatctcg tcgtccgggg ccacggtccc gttcgtctcg aactccacgg
    10981 tgacgcccgc atcgagcagc ctcttcagca cggggcgcag ccggcgctgc tggctcaacg
    11041 gctcgccacc gctgatgacg acgaggtcgg tcccgagcgc gaggagctcg tcgaccactt
    11101 cgtcgacgtc cctgttgtgc agttccttgc gggggtcgaa cgcggtcttc tcgtcactcg
    11161 tccccttcca gtcccaggtg tacggggtgt cgcaccagtg gcaggacagg ttgcacccgc
    11221 ccagccgcag gaaggcgcac tgacggccgg ccgacgggcc ctcgccctgg accgtggggc
    11281 cgaagatctc attgacgacg atgctcacgg ccggtactcg gcccaggtct tgtcggtctc
    11341 cgagacgcgg acggcgctga gctcggggta gcgctccgtc cactggtcat agatccacat
    11401 ggccatgttc tcggcggacg ggttccggtc ctcgatgatg tcgttgaggt gccggtggtc
    11461 cagcgtgtgg tcgagccact tcttgaagtc ggccaggtcg ccgtagtccc gtacgaaacc
    11521 gggctcggtc agctggtccg gggccgcgga gagcttcagc tcgatgatgt agttgtgccc
    11581 gtgcagccgg gcgcactggt ggtccgaggg caggtgttcc agccgatgac tcgccgagaa
    11641 gtgaaattcc ttcgtgatgt gcagcatcaa cctactcctt gaagtaaacc gtggggtcag
    11701 tcgtctctgc gcgctcgaac gcctggatcc ggtcgacgca cgcggcgcat gttccgcagt
    11761 gcacctcagt gcccttgaag cagctccagg tctcggccca gtcgacaccc agcttttcgc
    11821 cgagccgaat gacgtcgtgc ttgtggagat cgatgaaggg ggccacgacc tccagatgcg
    11881 ccggcgcgta tccggcgcac gcaatcttct ccatcgcatt gaaagaggag atgaattcgg
    11941 ccgaacagtc gggtgcggtc gacgcatcgc ccgccagagc cccgatggca acctgatccg
    12001 ccttgacagc ggcggccttt ccataggcta cggacagcag aatcacattg cgattcggta
    12061 cgacgttaac acttccgggg gccgtgtagt gctgatccgg aacatcgacc tgggaatccg
    12121 tcagggagta tccgggaagc atggaagcga cgttcgacag atcgacgatc tcgtgctcgg
    12181 cgccgatacg gtcggccgcg atccgggcgt agtcgtgttc tttgcgatgc cgctgaccgt
    12241 agtcgatgga gagcagatgt acctcatgcc cttcggcatg aagatgatgg gcgagtacga
    12301 cggagtcgag cccgccggaa acaatcgcga tcacacgtgc cacggtgacg ccttcctgca
    12361 aacggaatgg gtggtggggc ccggacgcgg gcacactgcg gtgtccttcg catcagcggc
    12421 gtacggtctt ccgcgcacgc ctcggtgacg ggccgtcggg cagccgggaa agagaaaccc
    12481 ggaaagaagg ggaaggtgcg gtaagaattg agcagcggag tcggcgcccc tcgcatcgag
    12541 ggcagcccca cactccggaa aggcggccgg gcgacctaat ccaccggggt gccggccagg
    12601 cggacgagtg gtgtcgcggc acgcagagcg tcggcgcact cctgcggaga gacaccggtc
    12661 gtgaccacgt acgcataccg tccggccaca tggtcgcggg gcggcagccg aaggcggcgg
    12721 cccggctccg ccatgggcgt cacctcgtgg acccccgccg gcagctcttc ctcgaccgtc
    12781 agggaggtga cgtcgagatc gtgctcggga tacaggaact cgacgtgggc ggaggcggtg
    12841 cgcaccggcg ccacgtcggg ccggccgccc gcggcgaggt cggcggccac catgccgtag
    12901 tcgacgcccg tggccaggcg ggccgcgtac gggatgaggt cgccgccgag gcgggcgttg
    12961 acctccacca ggcgcgggcc ggtccgggtc agccgcagct cggtgtgggt caccagcgtg
    13021 tcgagtccga gcgcggtgtg cgcctcctgg aggacgcgcc gcacctccgg gtcgtgcagc
    13081 agcgggtcgt ccgcgctgac cgtgtggccg acctcctcga agtgcggggc gaagccgagg
    13141 gccttgaggg ccacgaacat cggggtcacg cggccgttgt ggcacacgct ctcgacactg
    13201 acctcggggc cgtccaggta ttcctcgacg agcacccacg cgcggtcgcg cgggatctcg
    13261 tcgaagtacg ccgccgccgc ctcggagtag gcggagtcca gggcctcggg cccgtccgcc
    13321 cgcacgaccc cgacgctggc cgcgagggca cgcggcttca gcacgacggg gtaaccgatc
    13381 gcccccgccg cctcccgcgc ctcttccagc gaagcgacgg cacgggagac gggctgcgcc
    13441 acaccggcgg ccgccagggc ctggcggccg aggtgcttgt cccggcaggc gagaacgcct
    13501 tcggcgttcg ccgtcggcag cttcagctcc tcggccatcc tggccgcgat cggcacccgg
    13561 atctcgtcgt agcagagaac gccggccatc tccacgctct cggtgagccg aacggcggcc
    13621 tcgatcgatt cgaatgcgtc gagcgtgtcg acgatcgtgt ttccccggag ataacgtgat
    13681 tcccaggtgg gctccttggg agcgaagagc cagagatcat agaagtcggc aaccgacttc
    13741 agaatgtatt cacgccacag ttgcccgccg ctccccacca gaagaagaca ctggcgagtt
    13801 gatcggtcat gtgacccggc ttccgccgca tccccttgtg gctcaccaac tcgtggcatt
    13861 gcaggaaccc cgttcaacgt tttcgcgata agccttgatc cgacttcgat ccagcgcaca
    13921 ccactgttac ctgatcgtct caccacgtct acagcgaacg aggatcgaaa acacgtcggc
    13981 agtaaaacga gggggggaga aatcggatat tagccagata gccgatgaat cacgtgacac
    14041 cgccggcatc actcttcgcc agctgttcat gcaggagata accggcatgg agccggttac
    14101 gtgctcctat ttcctgcatg aggtcggcaa tgtgccgctg acaggtcctc agagagagcc
    14161 ccacccgcgc cgcgatcttc ttgtcgctct cccccaccac aaggaggcgc atgatggtgt
    14221 ccttgacctc ggaggagacg tgtacgatct ggcccttgct gtagctcagg gggaaggggc
    14281 gggctccgac ccaggtccgc tcgaaggtgt ccaccagcac gtcgatgacg ttctcgttgc
    14341 gcaggacgag ggccccctcg gggtgtcctt tcagcgcaag gacggccacc cgccggtcga
    14401 agacgagcat gcgcgggaag ccgctggccg tggtgcggac ctccccgccg agcggcgcca
    14461 catgttcgac gtaggcggcc gtgccttgat ggaactgcgc ggtgtgctgg tagagcgtgc
    14521 gcatgcggac accgcgttcc agcagctcct gggcgaacgt cagggcggtc tcgagctgct
    14581 tcaccggccg gccgccgccc ggctgggagg tgagcacctc cgtcgtggcc cgtgcgctga
    14641 actcctcgat gagggtcagc accacgtcca ggtcacggac cacctcgatc tgcccggcgg
    14701 ccgattccac ctcgtcccag tagaccggca gcagtgaccc gaggtcggct cgaatccggt
    14761 ccgccttctc ctgcatgacg gagatctcgc gtaccagcgg cccgaggagg cgcagttggg
    14821 ccgagtcggg cgccacggcg gcgaacaggt cgcctcccgc gtcctgttgg agcagtcgca
    14881 gctccaccag gcccgcgatc acccggtcgg cctccgatgc gtccaggccg agttcgtccg
    14941 ccacgacctc cgcggtcagc gcgcggcgtc gcacggccag ggcgtacgcg cgccgcatgt
    15001 ccgtggacag atgcatatcc atatatcgac caagcgcccc tcgtggtgct tcgcgtcccc
    15061 ccgcgcgcca tgcgccaccc cttgtcatct gagcagacct aatctggtca gtggggggtc
    15121 cggaccagcg actatcgaac ttcgcacgcg cgtgaggcct tgtcaaaggc ggttttttcg
    15181 gccggtgttg gcctgaaatg attgaccctc cgagagatca atggtgtaag cgggccgata
    15241 aacggagaac gcgggttatg tatcgccccc tgtacggaaa tggcccggca tccgacttat
    15301 accgagggga accagggggc tgtcgccggt gaacgccgcg ccggtccacg acagtcacca
    15361 gagtcctcat atgcacccct tgtgcccctt gtacccctag cgggttcccg ccaacagaga
    15421 ttcgacccgg gtcggctctg gacatgtcgc tgcgcgacca caaagagtgg tcaccgacca
    15481 tgcgcacaga acgcgggaac gcacggggga acaaccgaac atgagacttg tcaccgaaat
    15541 cctgaagagc tccctgctgg cggcgacgct gctcggtctc gcagggccga ccatcgacgc
    15601 ctccaaccgg tcgacgcagg ccgatacgcg ggcgaattcc gcctcgtgcg gccacgcctg
    15661 cccgaacaac gcgccggggg cagatctcgg ctggggctga tccgcgtcct cacctcaccc
    15721 ttccccgcac cccagcacac gccgccgtgc gagcggaacg gcctttggtg atttcgtacg
    15781 cccatgccgc tcgtcctccg cgccctgtga ggtgacgcct tgctccacac ccgtcgtcgt
    15841 ccggtcggtt ccgtcctcct cctcggcgga acccgccccg aaccggtcag agccgccaag
    15901 gcggccggac tctccatcac ctacctcgga gccgcggcgc ggacaccccg tgacatcctc
    15961 gacaacgccg acgggtgcct cctgctggag gaccccacac cggagaacat gaccgaggcc
    16021 gcccggaaac tgcacgccga gaagtcgttc ggtgtggtcg tcaccatggt cgaccggtac
    16081 ctggaggccg ccgccctcct caacgcggaa ttcggccttc cggccaatac cgtcgacacc
    16141 gtgcggtcga tgaacgacaa gcaccggatg cgcgcggcgg ccctgcactc cgcctgcgcc
    16201 ccggtggccc acgccgccgt ccgcaccgcc gaggacctgc ggtccttcgc gggccggcac
    16261 ggctacccct tcatcctgaa gccggtggac ggctcggcga gccgcggcgt cgccctcgtg
    16321 tccgacgccg gcacgctcga gtccgcggcc cgggccatga ccggttcggc cgcgccggag
    16381 tcccgctgga tcgccgaaga gttcctctcc ggacccgagt tcagcgtgga gactttcagc
    16441 accgacggca gccaccacgt ggtggccgtc accgagaagt tcaagggcga caacttcgtc
    16501 gagatcggcc atctggtccc ggcccgggtc cgcgcggcgg atcacgccgc catggccgcg
    16561 gaggtcggtg ccctgctcga cgccgtcggt ctgaacgagg gcgtcgccca caccgaggtc
    16621 gtcctcacgg acgccggacc gagggtcgtc gagacccaca gccgcccggg cggggacggc
    16681 atcgtcgaac tcgtacgcct ggccaagggt gtcgacctcc agcagatgac cttcgactgg
    16741 ttcgcgggca agcccgtcga cccactcctg gcaccagcgg cgagagcctc ggccacctgg
    16801 tccctcacgc cgcccgaggg caccgtcacg gccgtctccg gtctcgacga ggcgctccgc
    16861 cacgaagggg tgacggaggg gtacacggtc ctcgaaccgg gcgacacggt ccgtccgctg
    16921 cgcagctccg acgaccgcag cggggcggtc atcaccgtcg cccccggccc cgacgccgcg
    16981 ctcgcgcggg cgcgggcggc cgtggatctc atcgatgtga ccgtcgtccc ggccggcgcc
    17041 gacctcgggg ggccggttcc gcgatgagcg gagaacgctc ctacggatac cgggtgctct
    17101 tctccgagcc ggggatcctc gtctacgccc ttgcagccgc cttcggcaag ctccaggcgg
    17161 gcatgttcgc actgggcacc ctgtacgcgg tcgccgacca gcgctcgtac agcgccggcg
    17221 cgttcgtcgt ggccgtgtcg gccctcggcg gactgtccac cccgctgcga ggccggctcc
    17281 tcgaccgcta ctcctacggc ccggtcctgt ggacgatcat ggccatccat acggtcctgg
    17341 tgggggggct gctggtcaac gagcacaggg gagggccgtt ctgggtcacg gtcgcctcgg
    17401 gcctgctggg caacctcgcc gctcccccca tcggcgtcgt cacccgtgtg atgtggcggt
    17461 cggtcaccac ggagaagagc cgtcccacag ccctggcctt cgactcggtc ctggccgacg
    17521 ccggcttcat tctcggcccg gccctggccg cgctcgtctg cgccaccctc gctccctggg
    17581 ccggtctggc ggccgtcctc ttcttcaccg cggtggccat gctgctgctg ccgaagaaca
    17641 tcggcgacga caagacctcg gccaggcagg gcgaccgcca ttgggccggg ccgctcacca
    17701 gcccgcggct ggtcctcctg ctcggcgcgg ccctgtgctt cgccacgtcc gtgagcgtgc
    17761 tggagatcgc cctggcgacg ccccacggcg acggggactc gaaggtgctg agcggactgc
    17821 tggtgagtgt gctggccacc ggcagcatcg tgggcggtct gctgatcggc gcgatgacgc
    17881 cggaactggc caagcgggcg actcgactgc cggttctgct gatgtccctg gccgtcttct
    17941 ccaccgcgct cgccttcggc aacaaggcgg gctggctggt cgccgtaccg ctctgcctgc
    18001 tcaccggcct ctccttcggc ccgtccttcg tcgccgtgta cggccgctcc ggcgacctcg
    18061 cgcccgcggg catggccgcc gagacccagg cgtgggccgg caccgccctc cagctcggct
    18121 ccgccgccgg tgccggcgcc ggcggtgtgc tgctggacat atggggccct ccgggcgcac
    18181 tggccctcgc cccgatggcc gccgtgatcg gcgcggcgag cgccttcgcg ggcgaccgcc
    18241 tgcggacacc ggtggccgag ccccgggggg acgcgattcc ggagagcctg tagtggggtt
    18301 cacgctgaac ctccggccgg aagggccgga catcggccgg cctgcccggc gttgtcccgg
    18361 tcggccgtgc ggccgaccgg gacagcggtc acgtccggga tgccggcggc ccgctcttca
    18421 ccgcgaggcg tcccttgccc ctatgccgac accggggcgt gcacctcgat gcgggcggag
    18481 gggctgaact tcgccagcgc ttcggccagt tcggcggcgg cggtctccag ttcggccacc
    18541 ggcatggggg ccaggccctc caacaggaag agaccggacg tcgtctcctc ggtgaggcgg
    18601 gtgcgcggac cctgacgcca gttccagcgg cggcaggtga caccggcgtc gtcgcaccac
    18661 accacctcgc ccgcgtcggg gtgttcgacg gtcctctcgc caccggtcac ggtgacgaag
    18721 tcctcgtctc cctcggcgcg taccagtcgc atcccgccct cgatgaggtc gaggtcctca
    18781 ccacccacgg ggatcaagtg ggcaacgctg atggcgttgt agaggtccac cagcaggttg
    18841 atccggggca gaccggcgtc ggacagtgcc cgcttggcca gcgcttccgc cgagttgcgg
    18901 gtgcgtgagg gcttggagcc gaaggcggtg tacgtctccc gccaggaggt cacgtgcggg
    18961 tcctcgtggg gagcacgtcc gtccaggcgc acggcgaggc ggcgggcggc ctcgtcgagg
    19021 aaggcggaac tctcctcgga actgggtccg ttgacaaggt cgtacgcctc gatcgcgaca
    19081 tgcgtgaagg tcggcgcgag ggtgtaaacc tcgtcggcca cggtcagctg gaacgtcatc
    19141 tgtctcgcct cggggggctg gaaggtcaca ggggcgaccg ggcccaggac gactgtcacg
    19201 gcgccgagaa cggccgcgaa ttcaccctac aggaccggcc gattcccctg tgggcctcct
    19261 tgaccccgag tgacgacggc ggtacgggag ccgaccgggc atgctccggg tacgttcgac
    19321 gcgttcctgg cgcgaacccg ggagatgtcg acgcccggca tatcccgtcc cggtggcggg
    19381 tagtggcccc acgcgcctct ccctggagcg tccatgctgc ggatccactt cacccccgag
    19441 gacctgacgc gggtcagggt ggccccgggt ccggacttcc tgtgggagat caccaatagc
    19501 gtgcagaccc tgcaacggac cgacggggag cgggtgttcg gcacctggcg gcgctgggtg
    19561 cggccgcggc tcccggagag ccgccgactg ctctccccgc ttctgccgcc ccgcgggtac
    19621 tcccccgact tcctcacccc cacctcgggt gaccgcacca cgctccgggc agccgtcgac
    19681 accctgctcg gtacgccgcg gccgagactg cgggcggagc tgagccggct ggccgggacg
    19741 agacggctgc ccggccgggc cgccgccctg gccgaaggcg acccggacgc gctcgccagg
    19801 ctgggcaagg cgctccacgc ctatcaggca gaggtgctcg taccccactg gcggcacgtc
    19861 cgcgcggcac tggaggcgga ccgggctctg cggacacggc atctgatgga cggcggcacc
    19921 gaggcgctgc tggccggtct cgggcccgac gtccggtggc ggccgcccgt gctggaggtc
    19981 acctacccgg tcgagcagca tctgcggctg aacgggcggg gcctggtgct ccagccgtcg
    20041 ttcttctgct ggcccacccc gaccaccctg gcggacggtg acctgccgcc cgttctggta
    20101 caccccatcc gccactcggc cgactgggcg gagggcgcgg cggccccgga acgggcagcg
    20161 ggcccgaacc ctctcggccg tctgctcggg cagacccgcg ccgacctgct gcgggccacc
    20221 cgcgccgggt gctcgaccat ggaggcggcc cggatgctcc aggtgaccca cccggccgtc
    20281 agccagcaca tgaacgtcct gcgtgcggcg ggcctgacca ccactgtccg cacggccggt
    20341 cgcgcctttc acgtggcgac tgccgagggg cgtgcgttgc tggccgccga ggaccgccgg
    20401 gcggggcgcg ggtagatcgg cgaactcccg tacgtaagcc aggacttaca gcgcttgtgc
    20461 ccgtcaccgc cgggccccca cgctgtcttc tgtcaccgcc ccggccggac ggccccacct
    20521 cgccccgccg cgacgttccc gtacggcacc gcccccacag gagccctcat gcgcccgaga
    20581 cttgtccccg gcacgatcgc agcactcgcg atcggagcac ttcttctccc cggcaccgcc
    20641 gaggcctccc ccgcccccgc cgtcccggtc gtggacgtac gggcccacga ctcgacgtcc
    20701 ggcacggccc tcgcctccgg atacggcaag ccgggaacca ggctgcgcgt cgacgccgga
    20761 cggtcgagca acgcccgctg gctggagatc gactaccagg tccagcagac cggttactgg
    20821 tgcggtcccg ccgcgacccg catcgcgctc tccgcccgca ccgccgcacc gagccagggc
    20881 gagctggcgg cgcagctcgg cacgaccgag gcgggcaccg atcacatcgg ccagatcacc
    20941 gcggtgctca acgcccgtct gggcagcggt tggtacgaga cgaaggagat gccgaacgac
    21001 ccgcccaccc aggcacagcg ggacctcctg tggcacgaca tcgtcttcga catcgaccgc
    21061 aactatccgc tggtcgccaa catcgtggcc cctccgggca accagccgcc cggctacccg
    21121 ccggaccaga cgatctacca ctacttcacc gtcttcggct acgacgcggt cgaccgcacg
    21181 gtcctcatcg ccgaccccgc gtccttcggc ggcaaccaga tctactggat ctccttcgat
    21241 caactcgcca ccctgatccc gccgaagggc tactccgcct gacgcgccgc gcaccgccct
    21301 cactcccacc ccctgaccag gaggacacgt tgagcaccca acggcccacc cgcagaggcg
    21361 tcctgaaggc cgccgccgga atctccgcga ccaccgcgct cggcgcggga ggcgtcctgg
    21421 cgtcggcgtc ggccgcccac gcggtgggcg acggcttcgg tctgcgcatc gtggaccgcg
    21481 acgaacgcga tccccgtatg cgctacttcc gcttcgcgac cgacgcgatc ggctggaacc
    21541 ccggcgtcaa cgtcctgctg ccggacggct accactccgg cgggcgcagg tatccggtgc
    21601 tgtatctgtt ccacgggggc ggaaccggac aggacttcat caccttcgac cggatgggaa
    21661 tccgcgcctg gaccgccggg aagccgctca tcgtggtgat gccggacggc ggggccgcgg
    21721 gctggtactc caacccggtc gtctccaacg tcggcccccg caactgggag accttccaca
    21781 tcggccaact gctcccgtgg gtggacgcca acttccgtac gtacgcggag tacgacggcc
    21841 gggcggtctc cggcttctcg atgggcgggt tcggcgccct gaagtacgcg gccaagtact
    21901 acgggcactt cgcctcggcc agctctcact ccggcccggc cagcctgcgc cgcgacgccg
    21961 gtctcgtcac ccactgggcc aacctctcct cggccgcggt ggagttgggc ggcggtacgg
    22021 tctacggcgc gcccctgtgg gacgaggcgc gggtcagtgc ggacaatccg gtgcagcgcg
    22081 tcgggagtta ccggaacaag cgggtgttcc tggtggcggg caccagcccc gacccggtca
    22141 actggttcga caccgtcaac gagacccagg tcctggccgg gcagcgggag ttccggggca
    22201 cgctgggcgc ggcggggatt ccgcacgagt ttcacgaggt gcccggcggc cacttcgtcc
    22261 ggcccgatct gttccggcgg gacctggacg ggatcgtcgc ccgcctccgt aaggcctgac
    22321 gggccggggc cacctgcgta cgg
//
