LOCUS       NZ_BMSI01000034         8777 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence34, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000034
VERSION     NZ_BMSI01000034.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 8777)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 8777
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000034.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..8777
                     /culture_collection="JCM:4185"
                     /db_xref="taxon:249586"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces asoensis"
                     /strain="JCM 4185"
                     /submitter_seqid="sequence34"
                     /type_material="type strain of Streptomyces cacaoi subsp.
                     asoensis"
     gene            <1..>8777
                     /locus_tag="IE189_RS38500"
     region          1..8777
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..8777
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..8777
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[2:>8777](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3..>8777
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     CDS             3..>8777
                     /NRPS_PKS="Domain: PKS_DH (215-368). E-value: 1.3e-42.
                     Score: 137.9. Matches aSDomain:
                     nrpspksdomains_IE189_RS38500_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (654-834). E-value: 1.6e-62.
                     Score: 202.7. Matches aSDomain:
                     nrpspksdomains_IE189_RS38500_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (944-1016). E-value: 2.2e-28. Score:
                     90.4. Matches aSDomain: nrpspksdomains_IE189_RS38500_ACP.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (1047-1471). E-value:
                     1.4e-180. Score: 592.6. Matches aSDomain:
                     nrpspksdomains_IE189_RS38500_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (1617-1915). E-value: 8.1e-102.
                     Score: 332.5. Matches aSDomain:
                     nrpspksdomains_IE189_RS38500_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (1988-2144). E-value: 3.7e-22.
                     Score: 71.4. Matches aSDomain:
                     nrpspksdomains_IE189_RS38500_PKS_DH.2"
                     /NRPS_PKS="Domain: ACP (2306-2379). E-value: 8e-30. Score:
                     95.0. Matches aSDomain: nrpspksdomains_IE189_RS38500_ACP.2"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (2405-2831). E-value:
                     3.5e-182. Score: 598.0. Matches aSDomain:
                     nrpspksdomains_IE189_RS38500_PKS_KS.2"
                     /codon_start=2
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058404.1"
                     /locus_tag="IE189_RS38500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I polyketide synthase"
                     /protein_id="WP_189928729.1"
                     /sec_met_domain="adh_short (E-value: 8e-67, bitscore:
                     210.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.4e-103, bitscore:
                     332.5, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.4e-16, bitscore:
                     45.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 1.3e-232, bitscore:
                     758.2, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.2e-94, bitscore:
                     301.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAVNGPTSVVIAGDAEALDEALEVLGADGVRVRRVAVDYASHTR
                     HVEAIEETLGEAFADVRAQVPLIPFYSTVTGGWVREADVLDGGYWYRNLRSQVRFGPAV
                     ADLLAGGHTVFVEASAHPVLVQPVSEIVDQGGTDAVVAGSLRRGEGGPRRLLTSMAELF
                     VRGVPVDWAGVLPAGAAAAHVELPTYAFDHEHYWLRSAPAVDAVALGQVGGDHPLIGAV
                     VGRPDSGGFLTTSRWSVEAYPWLGDHVVGGVVVVPSAVLVELAIRLGDEVGCAVVEELS
                     VDRPVLLPLRGGRAVQMTVGEADGQGRRAVEVFSRADDAGLEGVWTRHAHGMLVPGPVP
                     GSPSASGAVWPAGSPAAEVALDRAVSDADGYGLHPALLDAAVCTVLPPGMIATRWSGVA
                     LLASGAAAVRVRAARDSAGVSGLELVDATAAPVLTADAVVAEPFQPPPPEHAETTDTSA
                     PAALFQIDWTEHPLSPGDMAVDAGTMATVVDAEDVAALAAGGPAAAGMLVYEAGHAPAD
                     PREAVAAALAVLQAWLAAPALAHTRLVVIVPDAEADLTVAAVSGLLRSAQSEHPDRIVL
                     VESGPGEQCGAAEQCGGAAPSEHSTAVNAVRLAVATGEPRVRVRGGVAFAPRLKRAPLA
                     EDPRHTPLADDSRRELDPDGTVLVTGGTGTLGSLVARHLASGHGVRHLLLAGRSGPDAE
                     GAAALYEELTGLGATVTIAACDTADRDAVKALLAAVPDAHPLTAVVHTAGVLDDGVVTA
                     LTPDRFDTVLRPKLDAALHLHELTRDIDLAAFVLFSSAAGVLGNPGQGNYAAANACLDA
                     LALHRRRSGLPGVSLAWGYWNDASGMTRHLGATDLHRTRRLGMAGLSAAEGTALLDTAL
                     RAGDETPAALVATRFDLPALRASARAGTPVAPLLRGLAPAPRPAAASPHTGVTDSLRER
                     LDRLGERERTEALVDLVRRNAAQVLGHSGTDAIRADRAFKDAGFDSLTAVELRNRLAAA
                     TALSLPSTIVFDYPKPTLLAYHLRARLFGDDEQRGDGQERSGEEHTTANGAVLSDDPLA
                     IVAMACRFPGGVESPEDLWRLVAQGVDAVGEFPDDRGWDIDRHYDADPDSVGKTYVRHG
                     AFLDDATGFDAAFFGISPNEALAMDPQQRLLLETSWEAFERAAIEPSALAGQDIGVFVG
                     VNSHDYTVRTHHASGIEGFRLTGNSGSVISGRIAYQFGFEGPAITIDTACSSSLVALHM
                     AARALRQGECSMALAAGVMVMGNLETFVEFSRQRGLSPDGRCKAFADAADGTGWSEGVG
                     VLLVERLSDARRRGHQVLAVVRGTAVNQDGASNGLTAPNGLAQQRVIRRALADAGLSTS
                     DVDAVEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSVKSNIGHTQAAAGMAGVI
                     KMVMAMRHGVLPRTLHVDRPSTHVDWSAGSVELLAEARRWPETGHPRRAGISSFGIGGT
                     NAHIVIQQAPVEDAEASDRAATNDLAPGNGSATAPVPGRVADASAATEPISPGSARLPA
                     PAPVPEPAAVPVSVSARTAAALCAQAARLAHFVETRPEPALTDIAHALATTRARLDHRA
                     VLLATDRQQLADALRALGDGTPADGTVTGSPSEGKLAFLFTGQGSQWAGMGRELAERHT
                     VFRNAFTAACEAVERHLDGHLERPLREVVFAGPGTAEAALLDRTLYTQTGLFALETALF
                     QLLASWGVRPDLVAGHSVGEISAAWAAGVLDLADAGELVAIRARLMQALPEGGAMVAVQ
                     ATEAEVTPLLERATGEIAIAAVNGPGALVLSGAEDTVLDVAARLAEQGRKTKRLKVSHA
                     FHSPLMAVMLDEFRAVTARLRPRPAAVPVISTLTGALAKDGHFATPEYWADQVRHAVRF
                     ADAVTALRDQGAGTFLEVGPGGGLTALALDTLGTDHRGCFATLSADGSEETAVLTALAE
                     LHVRGTDIDWSALLGTPATAIGTELPTYAFQHQRYWVEPETTATDAEALGARTTGHPLL
                     GTAVEIPDDDHVGPVGDGGTRVVLTGRLDRRALGRLLDSGTDTAPAAVLLDLLVHAGTE
                     AGSGAVEQIVVDTPLTVPEHGHLQLRVHVDVPGRDGLRPVVVHSRRAGDEDSTWTRHAR
                     ALLRPGLPTPSFDLRTWPATTADAPADLLDIRGVRGMHSLTEQDGRLFADVSLPPELVD
                     EAAGFTLHPALLDTVLRLLAGRTGQSGRELTGCADLVVYAEGATALRLRATPVEGGRHL
                     VELADHTGEPVAALGPLTLGRTDSTLPAAEVGTPALREARATEDGPLVRRVVGRPDAES
                     GSPAHRLAALGATEQQRVLLDLVKESAAVVLGHTSAEALDEEQPFKDLGFDSLSAVRLR
                     NRLHDFTGMSLPSSLVFDYPTPSALARHLRTELLGEEADDLSAGVVRSGPAMPADPDEP
                     IAIIAMSTRLPGGVDSPEELWRLVTEERDALSGFPQDRNWDVDKLYHPDPTHPGTTYTR
                     VGGFLHDAAHFDAGLFGISPREALAMDPQQRLLLETSWEALERAGIDPLSARGHDIGVF
                     TGIVHHDYVTRLRQIPEDVRGYVMTGTSSSVASGRVSYVFGFEGPAVTIDTACSSSLVA
                     MHLAAQALRRGECSLALAGGATVMSSPDAFVEFARQRGLSADGRCKAYSSTADGTGWAE
                     GVGVIVLERLAEARRNGHRILAVLRGSAVNQDGASNGLTAPNGPSQQRVIRRALSDAGL
                     SAKDVDMVEGHGTGTSLGDPIEVQALLATYGKDRPADRPLWLGSLKSNIGHTQAAAGVS
                     GVIKMVEALRHGVMPPTLHVEEPTPQVDWTAGAVELLREARQWPDTGRPRRAAVSSFGA
                     SGTNAHVILEEAPEEPVDPSAAESGAELPAAPVVVPLVVSARSPGSLVGQAERLVSFLG
                     QNAGTLPHVAGALVAQRAVLSERAVVVAESGVEALAGLGALARGESKP"
     CDS_motif       7..45
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0001"
                     /evalue="2.50E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE189_RS38500"
                     /protein_end="14"
                     /protein_start="1"
                     /score="11.2"
                     /tool="antismash"
                     /translation="AAVNGPTSVVIAG"
     CDS_motif       115..147
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0002"
                     /evalue="1.40E-03"
                     /label="PKSI-AT-mM_m6"
                     /locus_tag="IE189_RS38500"
                     /protein_end="48"
                     /protein_start="37"
                     /score="11.5"
                     /tool="antismash"
                     /translation="VDYASHTRHVE"
     CDS_motif       256..303
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0003"
                     /evalue="1.30E-04"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="IE189_RS38500"
                     /protein_end="100"
                     /protein_start="84"
                     /score="14.3"
                     /tool="antismash"
                     /translation="LDGGYWYRNLRSQVRF"
     aSDomain        649..1107
                     /ASF="catalytic triad H,G,P inconclusive"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38500_PKS_DH.1"
                     /evalue="1.30E-42"
                     /label="IE189_RS38500_PKS_DH.1"
                     /locus_tag="IE189_RS38500"
                     /protein_end="368"
                     /protein_start="215"
                     /score="137.9"
                     /tool="antismash"
                     /translation="HPLIGAVVGRPDSGGFLTTSRWSVEAYPWLGDHVVGGVVVVPSAV
                     LVELAIRLGDEVGCAVVEELSVDRPVLLPLRGGRAVQMTVGEADGQGRRAVEVFSRADD
                     AGLEGVWTRHAHGMLVPGPVPGSPSASGAVWPAGSPAAEVALDRAVSDA"
     aSModule        649..3051
                     /domains="nrpspksdomains_IE189_RS38500_PKS_DH.1"
                     /domains="nrpspksdomains_IE189_RS38500_PKS_KR.1"
                     /domains="nrpspksdomains_IE189_RS38500_ACP.1"
                     /incomplete
                     /locus_tags="IE189_RS38500"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       733..801
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0004"
                     /evalue="3.30E-08"
                     /label="PKSI-DH_m2"
                     /locus_tag="IE189_RS38500"
                     /protein_end="266"
                     /protein_start="243"
                     /score="26.0"
                     /tool="antismash"
                     /translation="WLGDHVVGGVVVVPSAVLVELAI"
     aSDomain        1966..2505
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38500_PKS_KR.1"
                     /evalue="1.60E-62"
                     /label="IE189_RS38500_PKS_KR.1"
                     /locus_tag="IE189_RS38500"
                     /protein_end="834"
                     /protein_start="654"
                     /score="202.7"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="GTVLVTGGTGTLGSLVARHLASGHGVRHLLLAGRSGPDAEGAAAL
                     YEELTGLGATVTIAACDTADRDAVKALLAAVPDAHPLTAVVHTAGVLDDGVVTALTPDR
                     FDTVLRPKLDAALHLHELTRDIDLAAFVLFSSAAGVLGNPGQGNYAAANACLDALALHR
                     RRSGLPGVSLAWGYWND"
     CDS_motif       1969..2070
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0005"
                     /evalue="6.60E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE189_RS38500"
                     /protein_end="689"
                     /protein_start="655"
                     /score="25.2"
                     /tool="antismash"
                     /translation="TVLVTGGTGTLGSLVARHLASGHGVRHLLLAGRS"
     CDS_motif       2350..2457
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0006"
                     /evalue="9.00E-21"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE189_RS38500"
                     /protein_end="818"
                     /protein_start="782"
                     /score="66.5"
                     /tool="antismash"
                     /translation="AAFVLFSSAAGVLGNPGQGNYAAANACLDALALHRR"
     misc_feature    2769..2771
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        2836..3051
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38500_ACP.1"
                     /evalue="2.20E-28"
                     /label="IE189_RS38500_ACP.1"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1016"
                     /protein_start="944"
                     /score="90.4"
                     /tool="antismash"
                     /translation="DLVRRNAAQVLGHSGTDAIRADRAFKDAGFDSLTAVELRNRLAAA
                     TALSLPSTIVFDYPKPTLLAYHLRARL"
     aSDomain        3145..4416
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38500_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="1.40E-180"
                     /label="IE189_RS38500_PKS_KS.1"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1471"
                     /protein_start="1047"
                     /score="592.6"
                     /tool="antismash"
                     /translation="AIVAMACRFPGGVESPEDLWRLVAQGVDAVGEFPDDRGWDIDRHY
                     DADPDSVGKTYVRHGAFLDDATGFDAAFFGISPNEALAMDPQQRLLLETSWEAFERAAI
                     EPSALAGQDIGVFVGVNSHDYTVRTHHASGIEGFRLTGNSGSVISGRIAYQFGFEGPAI
                     TIDTACSSSLVALHMAARALRQGECSMALAAGVMVMGNLETFVEFSRQRGLSPDGRCKA
                     FADAADGTGWSEGVGVLLVERLSDARRRGHQVLAVVRGTAVNQDGASNGLTAPNGLAQQ
                     RVIRRALADAGLSTSDVDAVEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSVKS
                     NIGHTQAAAGMAGVIKMVMAMRHGVLPRTLHVDRPSTHVDWSAGSVELLAEARRWPETG
                     HPRRAGISSFGIGGTNAHIVIQQAP"
     aSModule        3145..7140
                     /complete
                     /domains="nrpspksdomains_IE189_RS38500_PKS_KS.1"
                     /domains="nrpspksdomains_IE189_RS38500_PKS_AT.1"
                     /domains="nrpspksdomains_IE189_RS38500_PKS_DH.2"
                     /domains="nrpspksdomains_IE189_RS38500_ACP.2"
                     /locus_tags="IE189_RS38500"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       3397..3423
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0007"
                     /evalue="5.20E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1140"
                     /protein_start="1131"
                     /score="6.9"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     CDS_motif       3622..3669
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0008"
                     /evalue="1.80E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1222"
                     /protein_start="1206"
                     /score="19.8"
                     /tool="antismash"
                     /translation="GPAITIDTACSSSLVA"
     CDS_motif       4045..4089
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0009"
                     /evalue="1.10E-02"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1362"
                     /protein_start="1347"
                     /score="8.8"
                     /tool="antismash"
                     /translation="VEGHGTGTVLGDPIE"
     CDS_motif       4150..4194
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0010"
                     /evalue="1.30E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1397"
                     /protein_start="1382"
                     /score="11.3"
                     /tool="antismash"
                     /translation="GSVKSNIGHTQAAAG"
     CDS_motif       4852..4902
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0011"
                     /evalue="8.30E-07"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1633"
                     /protein_start="1616"
                     /score="21.2"
                     /tool="antismash"
                     /translation="FLFTGQGSQWAGMGREL"
     aSDomain        4855..5748
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38500_PKS_AT.1"
                     /evalue="8.10E-102"
                     /label="IE189_RS38500_PKS_AT.1"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1915"
                     /protein_start="1617"
                     /score="332.5"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGSQWAGMGRELAERHTVFRNAFTAACEAVERHLDGHLERP
                     LREVVFAGPGTAEAALLDRTLYTQTGLFALETALFQLLASWGVRPDLVAGHSVGEISAA
                     WAAGVLDLADAGELVAIRARLMQALPEGGAMVAVQATEAEVTPLLERATGEIAIAAVNG
                     PGALVLSGAEDTVLDVAARLAEQGRKTKRLKVSHAFHSPLMAVMLDEFRAVTARLRPRP
                     AAVPVISTLTGALAKDGHFATPEYWADQVRHAVRFADAVTALRDQGAGTFLEVGPGGGL
                     TALALDTLGTDHRGCFA"
     CDS_motif       5113..5235
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0012"
                     /evalue="4.80E-18"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1744"
                     /protein_start="1703"
                     /score="57.3"
                     /tool="antismash"
                     /translation="GVRPDLVAGHSVGEISAAWAAGVLDLADAGELVAIRARLMQ"
     CDS_motif       5329..5367
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0013"
                     /evalue="3.20E-02"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1788"
                     /protein_start="1775"
                     /score="7.8"
                     /tool="antismash"
                     /translation="AAVNGPGALVLSG"
     CDS_motif       5584..5625
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0014"
                     /evalue="1.60E-01"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="IE189_RS38500"
                     /protein_end="1874"
                     /protein_start="1860"
                     /score="5.3"
                     /tool="antismash"
                     /translation="PEYWADQVRHAVRF"
     aSDomain        5968..6435
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38500_PKS_DH.2"
                     /evalue="3.70E-22"
                     /label="IE189_RS38500_PKS_DH.2"
                     /locus_tag="IE189_RS38500"
                     /protein_end="2144"
                     /protein_start="1988"
                     /score="71.4"
                     /tool="antismash"
                     /translation="HPLLGTAVEIPDDDHVGPVGDGGTRVVLTGRLDRRALGRLLDSGT
                     DTAPAAVLLDLLVHAGTEAGSGAVEQIVVDTPLTVPEHGHLQLRVHVDVPGRDGLRPVV
                     VHSRRAGDEDSTWTRHARALLRPGLPTPSFDLRTWPATTADAPADLLDIRGV"
     aSDomain        6922..7140
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38500_ACP.2"
                     /evalue="8.00E-30"
                     /label="IE189_RS38500_ACP.2"
                     /locus_tag="IE189_RS38500"
                     /protein_end="2379"
                     /protein_start="2306"
                     /score="95.0"
                     /tool="antismash"
                     /translation="LDLVKESAAVVLGHTSAEALDEEQPFKDLGFDSLSAVRLRNRLHD
                     FTGMSLPSSLVFDYPTPSALARHLRTEL"
     aSDomain        7219..8496
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38500_PKS_KS.2"
                     /domain_subtypes="Modular-KS"
                     /evalue="3.50E-182"
                     /label="IE189_RS38500_PKS_KS.2"
                     /locus_tag="IE189_RS38500"
                     /protein_end="2831"
                     /protein_start="2405"
                     /score="598.0"
                     /tool="antismash"
                     /translation="IAIIAMSTRLPGGVDSPEELWRLVTEERDALSGFPQDRNWDVDKL
                     YHPDPTHPGTTYTRVGGFLHDAAHFDAGLFGISPREALAMDPQQRLLLETSWEALERAG
                     IDPLSARGHDIGVFTGIVHHDYVTRLRQIPEDVRGYVMTGTSSSVASGRVSYVFGFEGP
                     AVTIDTACSSSLVAMHLAAQALRRGECSLALAGGATVMSSPDAFVEFARQRGLSADGRC
                     KAYSSTADGTGWAEGVGVIVLERLAEARRNGHRILAVLRGSAVNQDGASNGLTAPNGPS
                     QQRVIRRALSDAGLSAKDVDMVEGHGTGTSLGDPIEVQALLATYGKDRPADRPLWLGSL
                     KSNIGHTQAAAGVSGVIKMVEALRHGVMPPTLHVEEPTPQVDWTAGAVELLREARQWPD
                     TGRPRRAAVSSFGASGTNAHVILEEAP"
     CDS_motif       7474..7500
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0015"
                     /evalue="5.20E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="IE189_RS38500"
                     /protein_end="2499"
                     /protein_start="2490"
                     /score="6.9"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     CDS_motif       7702..7749
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0016"
                     /evalue="1.70E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE189_RS38500"
                     /protein_end="2582"
                     /protein_start="2566"
                     /score="19.9"
                     /tool="antismash"
                     /translation="GPAVTIDTACSSSLVA"
     CDS_motif       8125..8169
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0017"
                     /evalue="3.70E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE189_RS38500"
                     /protein_end="2722"
                     /protein_start="2707"
                     /score="10.0"
                     /tool="antismash"
                     /translation="VEGHGTGTSLGDPIE"
     CDS_motif       8230..8274
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38500_0018"
                     /evalue="4.00E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE189_RS38500"
                     /protein_end="2757"
                     /protein_start="2742"
                     /score="10.0"
                     /tool="antismash"
                     /translation="GSLKSNIGHTQAAAG"
ORIGIN
        1 ggtggcggcg gtcaacggtc ccacgtcggt ggtgatcgcg ggtgatgccg aggcgctgga
       61 cgaggcgctg gaggttcttg gggcggatgg tgtgcgggtg cgtcgggtgg cggtggatta
      121 cgcctcgcac acccggcacg tggaggcgat cgaggagacc ttgggcgagg cgttcgccga
      181 cgtccgggct caggtgccgc tgattccctt ctactcgacg gtgacgggtg ggtgggtgcg
      241 ggaggcggat gtcctcgacg gtggttactg gtaccggaac ctgcggagcc aggtccgttt
      301 cggtcccgcc gtcgcagacc ttctggccgg tggtcacacc gtctttgtgg aggccagtgc
      361 ccatcccgtc ctggtccagc cggtcagcga gatcgtcgac cagggcggca cagacgccgt
      421 ggtcgctggt tcgctgcgcc gtggggaggg tggcccgcgc cgactgctga cgtcgatggc
      481 ggagctgttc gtgcggggcg tccctgtcga ctgggcgggt gtccttccgg ccggtgccgc
      541 cgccgctcac gtggaactcc ccacgtatgc cttcgatcac gagcattact ggctgcgttc
      601 cgcgcctgct gtggatgctg tcgcgttggg tcaggtgggt ggtgatcatc cgttgatcgg
      661 tgcggtcgtg ggtcggccgg actcgggcgg tttcctgacg acttcgcggt ggtcggtgga
      721 ggcgtatccg tggctgggtg atcacgtcgt gggtggtgtc gtcgtggtgc cgagtgcggt
      781 gttggtggag ttggcgatcc gcttgggtga cgaggtgggc tgtgcggtgg tcgaggagtt
      841 gagcgtggat cggcccgtgc tgttgccgtt gcggggtggc agggcggtgc agatgaccgt
      901 gggggaggcg gacgggcagg gtcggcgggc ggtcgaggtg ttttcccgtg cggacgatgc
      961 cggcctggag ggggtgtgga cccgtcacgc gcacggcatg ttggtgcccg gcccggtgcc
     1021 cgggtccccg tcggcttccg gcgcggtgtg gcctgccggc agccccgcag ccgaggtggc
     1081 cctggacagg gcggtgagcg acgccgacgg ctacggcctg catccggcgt tgctggacgc
     1141 ggcggtgtgc acggtccttc cgccgggcat gatcgcgacc cggtggagcg gggtcgcctt
     1201 gctcgcttcc ggtgcggcag cggtccgggt acgcgcggcc cgtgactccg caggggtgag
     1261 cggtctcgag ttggtggatg ccacggcagc tccggtactg accgctgatg ccgtggtcgc
     1321 cgagccgttc cagccgcccc cgcccgaaca cgcggagacc acggacacat cggctcctgc
     1381 cgcgctgttc cagatcgatt ggaccgagca tcccctttcc ccgggtgaca tggctgtcga
     1441 cgccgggacg atggcgaccg tcgtcgatgc ggaggacgtc gccgcccttg ctgcgggcgg
     1501 tccagcggca gcgggcatgc tggtgtacga ggccgggcac gcgcccgccg acccgcgcga
     1561 ggccgtcgcc gccgcgttgg ccgttctcca ggcgtggctg gcagcgcccg ctctggcgca
     1621 cacccgcctc gtcgtgatcg tccccgacgc cgaggccgat ctcaccgtgg ccgccgtctc
     1681 gggactgctg cgttcggcgc agtcggagca cccggaccgc atcgtccttg tcgagagcgg
     1741 ccccggcgag cagtgcggcg ctgccgagca gtgcggtggt gcggcgccct cggagcactc
     1801 gacggccgtg aacgccgtgc ggctcgcggt ggccaccggc gagccccggg tccgtgtgcg
     1861 tggtggcgtg gccttcgccc cccggctgaa gcgggccccg ctcgccgaag atccccggca
     1921 caccccgctt gccgacgatt cccggcgcga gctggacccc gacggcaccg tcctcgtcac
     1981 cggcggcacc gggacgctcg gcagtctcgt cgcccggcac ctggcgagcg gacacggcgt
     2041 gcggcacttg ctgctggccg gccggagcgg accggacgcc gaaggagcgg cggcactgta
     2101 cgaggaactg accggcctcg gcgcgaccgt caccatcgcc gcgtgcgaca ccgccgaccg
     2161 ggacgcggtc aaggcgctcc tggccgccgt accggacgca cacccgctca ccgccgtcgt
     2221 ccacaccgcc ggagtcctcg acgacggtgt ggtcaccgcc ctgaccccgg accgcttcga
     2281 caccgtcctg cggcccaaac tcgacgccgc actgcacctg cacgaactga cccgggacat
     2341 cgatctcgcg gcgttcgtcc tcttctcctc cgccgccggg gtcctcggca accccggcca
     2401 gggcaactac gcggccgcca acgcctgcct ggacgccctc gccctccacc gccgccgctc
     2461 cggcctgccc ggagtctccc tcgcatgggg ctactggaac gacgccagcg gcatgacccg
     2521 gcatctcggc gccacggacc tgcaccgcac ccggcgcctc ggcatggccg ggctctccgc
     2581 cgccgagggc acggcgctcc tcgacacggc gctgcgggcg ggcgacgaga cccctgccgc
     2641 gctcgtggcc acccggttcg acctgcccgc cctgagggcg tccgcccgag ccggaactcc
     2701 cgtggcgccg ctgctgcgcg gcctcgcgcc cgctcctcgg ccggcggccg cgtccccgca
     2761 cacgggtgtt accgactcct tgcgtgagcg gctcgaccgc ctgggcgagc gggagcgcac
     2821 agaggcactg gtggacctcg tccgccggaa cgccgcccag gtgctcggcc actccggcac
     2881 cgacgccatc cgcgccgacc gtgccttcaa ggacgccggt ttcgactcgc tgaccgccgt
     2941 cgagctgcgc aaccggctcg cggccgcgac cgctctcagt ctgccctcca ccatcgtctt
     3001 cgactatccg aagccgacgc tgctcgccta ccacctgcgt gcacggctct tcggcgacga
     3061 cgaacagcgg ggcgacggcc aggagcggag cggcgaggag cacaccaccg ccaacggggc
     3121 cgtcctctcc gacgatcccc tcgccatcgt cgcgatggcc tgccgcttcc ccggcggtgt
     3181 ggagagccct gaagacctct ggaggctggt cgcccaaggc gtcgacgccg tcggggagtt
     3241 ccccgacgac cgcggctggg acatcgaccg gcactacgac gccgaccctg acagcgtcgg
     3301 caagacctac gtacggcacg gcgcgttcct cgacgacgcg accggcttcg acgccgcctt
     3361 cttcgggatc tcaccgaacg aggcgctcgc gatggacccc cagcagcggc tgctcctgga
     3421 aacctcctgg gaggccttcg aacgcgccgc gatcgaaccg agcgcgctcg ccgggcagga
     3481 catcggcgtc ttcgtcggcg tcaacagcca cgactacacc gtacggacgc accacgcgtc
     3541 cggcatcgaa ggcttccgcc tgaccggcaa ttccggcagc gtcatctcag gccggatcgc
     3601 ctaccagttc ggcttcgagg gcccggccat cacgatcgac accgcctgct cgtcctcgct
     3661 cgtcgccctc cacatggcgg cccgcgcact tcggcagggc gaatgctcca tggccctcgc
     3721 cgccggcgtg atggtcatgg gcaacctgga gaccttcgtc gagttctccc ggcagcgcgg
     3781 cctctccccg gacggccgct gcaaggcctt cgccgacgcg gcggacggaa ccggctggtc
     3841 cgagggggtc ggcgtgctcc tcgtggaacg gctctccgac gcacgccgcc gcggccacca
     3901 ggtcctcgcg gtggtccggg gcaccgcggt caaccaggac ggtgcgtcca acggactgac
     3961 ggcgccgaac gggctagcgc aacagcgggt gatccgcagg gcgctcgccg acgccggtct
     4021 gtcgacctcg gacgtggacg cggtcgaggg ccacggcacg ggaacggtcc tcggtgaccc
     4081 gatcgaggcg caggcactgc tcgccaccta cgggcaggat cgacccgccg accgcccgct
     4141 gtggctcggg tcggtcaagt ccaacatcgg gcacacacaa gccgcggccg gtatggcagg
     4201 cgtcatcaaa atggtgatgg cgatgcggca cggcgtcctg ccccgcacgc tgcacgtgga
     4261 ccggccctcc acccacgtgg actggtccgc gggctcggtg gaactgctcg cggaggcccg
     4321 ccggtggccc gagaccgggc acccgcggcg cgccggtatc tcgtccttcg gcatcggtgg
     4381 caccaacgcg cacatcgtga tccagcaggc tccggtggag gacgccgagg cctccgaccg
     4441 ggcggcgacg aacgacctgg cacccggcaa cgggtcggca accgcgcccg tcccaggacg
     4501 ggttgccgat gcgtcagccg ccacagaacc catatcgcca ggttccgccc gcctgcccgc
     4561 gcccgcgccc gtgcccgagc ccgcggccgt gcctgtgtcc gtgtcggcac ggacggcggc
     4621 ggcgctgtgc gcgcaggccg cgcgcctcgc tcacttcgtc gagacacgcc ccgagccggc
     4681 cctcaccgac atcgcacacg cgctggccac cactcgtgcc cggctcgacc accgggcggt
     4741 gctgctggcc accgaccggc agcagctcgc cgacgcgctg cgcgcgctcg gcgacggcac
     4801 gcccgccgac ggcaccgtca ccggcagccc ctccgagggc aagctggcct tcctcttcac
     4861 cgggcagggc agccagtggg ccggcatggg ccgcgaactc gccgagcggc acacggtttt
     4921 ccggaacgcc ttcaccgccg cgtgcgaggc ggtcgaacgg cacttggacg gtcatctgga
     4981 acgtccgctg cgcgaggtcg tgttcgccgg gcccggcacg gcggaggccg cgctgctcga
     5041 ccgcaccttg tacacgcaga cgggtctctt cgccctggag accgctctgt tccagctcct
     5101 cgcctcctgg ggtgtacgtc cggacctggt cgccggacac tcggtcggcg agatctccgc
     5161 cgcctgggcc gccggagtcc tcgacctggc ggacgcaggc gaactggtcg ccatacgcgc
     5221 ccggttgatg caggccctgc ccgagggagg cgccatggtc gccgtccagg cgaccgaggc
     5281 cgaggtgaca cccctgctgg agagggccac gggcgagatc gcgatcgccg cggtcaacgg
     5341 acccggcgcc ctcgtgctct ccggtgccga ggacaccgtc ctcgacgtgg ccgcgcgact
     5401 ggccgaacag ggccgcaaga ccaaacgcct gaaggtcagt catgctttcc actcgcccct
     5461 gatggccgtc atgctcgacg agttccgagc cgtcactgcc cggctgcgtc cccgcccggc
     5521 cgccgtaccc gtcatctcca cgctcaccgg tgccctcgcg aaggacggcc acttcgccac
     5581 cccggagtac tgggccgacc aagtgcgcca cgcggtgcgg ttcgccgacg cggtcaccgc
     5641 gctccgcgac cagggcgccg gaaccttcct ggaggtcgga cccggcggcg gcctgaccgc
     5701 cctcgccctc gacacgctcg gcacggacca ccggggctgc ttcgccaccc tgagcgcgga
     5761 cggctcggag gagaccgcag tcctcaccgc actcgccgaa ctgcacgtcc gcggcacgga
     5821 catcgactgg tccgccctcc tcggcacccc ggccacggcg atcggcaccg agctgcccac
     5881 gtacgccttc cagcaccagc ggtactgggt cgagcccgag accaccgcca ccgacgccga
     5941 ggcgctcggc gcccgcacca ccgggcaccc ccttctgggc acggcggtcg agatccccga
     6001 cgacgaccac gtcggtccgg tcggcgacgg cggcacccgt gtggtgctca ccgggcggct
     6061 cgaccggcgt gccctcggcc ggctcctcga ttccggcacc gataccgctc cggccgccgt
     6121 actcctcgac ctgctggtcc acgccggaac cgaggcggga agcggcgccg tcgagcagat
     6181 cgtcgtcgac accccgctca ccgtgcccga acacggccac ctccagctcc gtgtccacgt
     6241 cgatgtcccc ggccgcgacg ggctgcgccc ggtcgtcgtc cacagcaggc gggcgggcga
     6301 cgaggacagc acctggacgc gccacgcccg cgcactgctc cggccaggcc tgcccacgcc
     6361 gtccttcgac ctgcgcacct ggccggccac cacagccgat gccccggcgg acctcctcga
     6421 catccgcgga gtacgaggga tgcacagcct gacggaacag gacggtcggc tcttcgccga
     6481 cgtctctctg cctccggaac tcgtcgacga ggccgcgggg ttcaccctcc atcccgcact
     6541 cctcgacacg gtccttcgcc tcctggccgg ccgcaccggt cagagcgggc gcgaactcac
     6601 cggctgcgcc gacctggtcg tgtacgccga aggcgccacc gccctgcgac tgcgggccac
     6661 gcccgtggag ggcggacgcc acctcgtgga gctcgccgac cacacgggcg aaccggtcgc
     6721 cgcgctcgga cccctgaccc tgggccgcac ggacagcacc cttcccgccg ccgaggtcgg
     6781 cacccccgct cttcgcgagg cacgggcgac ggaggacggc ccgctcgtcc gacgggtcgt
     6841 gggacgtccg gacgccgaga gcggctcgcc ggcccaccgg ctcgccgcgc tcggagccac
     6901 cgaacagcag cgcgtcctgc tggacctggt gaaggagagc gcggccgtcg tcctcggcca
     6961 caccagcgct gaggccctcg acgaggagca gcccttcaag gatctcggct tcgattccct
     7021 cagcgccgtc agactccgca accggctgca cgacttcacc ggcatgagcc tccccagcag
     7081 cctcgtcttc gactacccga ccccgtccgc gctcgcccgg cacctgcgca ccgaactgct
     7141 cggtgaggaa gccgacgacc tgtcggctgg agtcgtccga tccggacccg ccatgcccgc
     7201 ggaccccgac gagccgatcg ccatcatcgc catgagcacc cgcctgcccg gcggcgtcga
     7261 cagccccgag gaactgtggc gactggtcac cgaggaacgc gacgcgctct ccggcttccc
     7321 gcaggaccgg aactgggacg tcgacaagct ctaccacccc gaccccaccc accccggcac
     7381 cacctacacc cgcgtcggtg gattcctgca cgacgccgcc cacttcgacg ccggactctt
     7441 cgggatctcg ccgcgcgagg ccctcgcgat ggacccgcag cagcggctgc tcctggagac
     7501 ctcgtgggag gccctggaac gggccgggat cgaccccctc tccgcccggg gccatgacat
     7561 cggtgttttc accggcatcg tccaccacga ctacgtcacc cggctgcggc agatccccga
     7621 ggacgtccgg ggctacgtga tgaccggcac ctcgtcgagt gtggcgtcgg gacgcgtgtc
     7681 gtacgtcttc ggcttcgaag gaccggcggt gaccatcgac acggcctgct cgtcctccct
     7741 cgtggcgatg cacctcgcag cccaggcgct gcggcgcgga gagtgctcgc tcgccctcgc
     7801 gggcggtgcg accgtcatgt cgagcccgga cgccttcgtg gagttcgccc gccagcgcgg
     7861 actctccgcc gacggccggt gcaaggcgta ctcctcgacc gccgacggca ccggctgggc
     7921 cgagggcgtg ggcgtcatcg tcctggagcg cctggcggag gcccgccgca acggccaccg
     7981 gatcctggcg gtgctgcgcg gcagcgccgt caaccaggac ggcgcctcga acggcctgac
     8041 ggctcccaac ggaccctccc agcaacgcgt catccggcgc gccctgtccg acgcgggcct
     8101 gtcggcgaag gacgtcgaca tggtcgaggg ccatggcacc ggcacatccc tgggcgaccc
     8161 gatcgaggtc caggcactgc tcgccaccta cggaaaggac cggcccgccg accgtccgct
     8221 gtggctcggc tcgctgaagt ccaacatcgg ccacacccag gcagcggcgg gtgtctccgg
     8281 cgtcatcaag atggtcgagg cgctgcgaca cggcgtcatg ccgccgacgc tccatgtgga
     8341 ggagccgaca ccgcaggtgg actggacggc cggcgcggtc gaactgctca gggaggcgcg
     8401 ccaatggccc gacacgggcc ggccgcgccg tgccgccgtc tcctccttcg gcgcgagcgg
     8461 caccaacgcc cacgtgatcc tggaggaggc acccgaagag cccgtcgatc cgtcggcggc
     8521 ggagagcggc gcggaactgc ccgccgcgcc cgtcgtggtg ccgctggtgg tgtcggcgcg
     8581 gagtcctggc tcgctggtgg ggcaggcgga gcggctggtg tcgttcctcg ggcagaacgc
     8641 gggcaccctg ccgcatgtgg cgggtgcgtt ggtcgctcag cgtgcggtgt tgtccgagcg
     8701 tgcggtggtg gtggccgagt ccggggtgga ggcgttggcg gggcttggtg cgctggcgcg
     8761 gggtgagtcg aagcccg
//
