LOCUS       NZ_BMSI01000030        23438 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence30, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000030
VERSION     NZ_BMSI01000030.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 23438)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 23438
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000030.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..23438
                     /culture_collection="JCM:4185"
                     /db_xref="taxon:249586"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces asoensis"
                     /strain="JCM 4185"
                     /submitter_seqid="sequence30"
                     /type_material="type strain of Streptomyces cacaoi subsp.
                     asoensis"
     region          1..23438
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /tool="antismash"
     cand_cluster    1..23438
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23438
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[2711:5227](+)"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_product_classes="pentangular polyphenol"
                     /t2pks_product_classes="tetracenomycin"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
                     /tool="antismash"
     proto_core      2712..5227
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_product_classes="pentangular polyphenol"
                     /t2pks_product_classes="tetracenomycin"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
     gene            195..911
                     /locus_tag="IE189_RS38235"
                     /old_locus_tag="GCM10010496_77610"
     CDS             195..911
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670654.1"
                     /locus_tag="IE189_RS38235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77610"
                     /product="class F sortase"
                     /protein_id="WP_189928678.1"
                     /transl_table=11
                     /translation="MAVPPSSAPSPSDPAGEPPPAEEGRSRTGLTMICAAAAALLALNL
                     FGGNDTSSGAPSPPHAPPAAGSLPAASGAGAAQADGGAPAGKHLPRSRPVRLLIPKIAV
                     DAPFTDLAIGADGRLEPPPAADVNLVGWHAAGVSPGEAGTAIIAGHVDTKTSPAVFAGL
                     SGLTKGDGFQVLRADGSKASFRVDDVETFDKADFPDERVYADTAQAQVRLITCAGNYDR
                     RVKDYTDNLVVFAHLV"
     gene            1049..2200
                     /locus_tag="IE189_RS38240"
                     /old_locus_tag="GCM10010496_77620"
     CDS             1049..2200
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020113636.1"
                     /locus_tag="IE189_RS38240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77620"
                     /product="SchA/CurD-like domain-containing protein"
                     /protein_id="WP_189928679.1"
                     /transl_table=11
                     /translation="MTTTSERVAGSRARQASQRVSQSVFDGSRLRVVLLVDVYDGAQQQ
                     FLEAYEQLCNQVASVPGHVSDQLCQSIENPSQWLITSEWESAPPFLAWVNSEEHVAMVE
                     PLHSCVRDTRSLRFHVVRETGGPATGADRAERRLQSSPRIGDGVIRHALTFTVKPGSEE
                     IVAKILADYASPEPQVDDTTRLCRTSLFMHGNRVVRAIEVRGDLLSALRHVSRQPEVRA
                     VEEAINPHLEQDRDLNDPESARVFFTRAALPAVHHVTAERMDAQAERYALYYPTRADGG
                     MKLAELLARQDEAAADDPRSPVLRSTIFQRDDCVVRLIDVRGGLEAADPGQALGLSDPG
                     QVAELTTLEDDAAGASASKDGRLARFLERARMDLVTDRRSPDA"
     gene            2272..2715
                     /locus_tag="IE189_RS38245"
                     /old_locus_tag="GCM10010496_77630"
     CDS             2272..2715
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MannoseP_isomer"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C5-C18
                     (Score: 210.2; E-value: 1.9e-65)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672287.1"
                     /locus_tag="IE189_RS38245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77630"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_229901626.1"
                     /sec_met_domain="MannoseP_isomer (E-value: 1.6e-08,
                     bitscore: 24.9, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITSRHRIVDLSEVEPNTRRGGDLRAMLTPATVGATSGFMGLALI
                     QPGDRIAEHYHPYSEEFVYVVCGQLEVDLDGEPHPLQPEQGLLIPLNVRHRFRNVGKVE
                     ARMVFHLGPLAPSPPLGHVDTEETVAEPVVVGAEAAGGRQVRS"
     misc_feature    complement(2285..2300)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.82"
                     /tool="antismash"
     gene            2712..3980
                     /locus_tag="IE189_RS38250"
                     /old_locus_tag="GCM10010496_77640"
     CDS             2712..3980
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (4-387). E-value:
                     5.4e-53. Score: 172.3. Matches aSDomain:
                     nrpspksdomains_IE189_RS38250_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     725.4; E-value: 4.3e-221)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009189295.1"
                     /locus_tag="IE189_RS38250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77640"
                     /product="beta-ketoacyl synthase"
                     /protein_id="WP_189928680.1"
                     /sec_met_domain="t2ks (E-value: 1.8e-211, bitscore: 692.9,
                     seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 6.2e-58, bitscore:
                     186.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRVAVTGIGIVAPGGIGVPAFWSLLAAGRTATRAITFFDPAGL
                     RSRIAAECDFDPAAHGLDARDVERCDRYIQFALVAGDEAVRDAGLDLAAENPWRVGVSL
                     GTAVGGTTRLEKDYVLVSNRGQRWDVDHREAAPDLHRAFTPSTLASTVAERFGARGPVQ
                     TVSTGCTSGLDAVGYAFHTVEEGRADICIAGASDSPISPITMACFDAIKATSPNNDDPA
                     HASRPFDADRDGFVMGEGGAVLVLEELEHARARGAHVYCELGGYATFGNAYHMTGLTSE
                     GLEMARAIEDALDHARIDAGSIDYVNAHGSGTKQNDRHETAAVKRVLGPHAYDTPMSSI
                     KSMVGHSLGAIGAIELVACVLALANQVVPPTANYETPDPECDLDYVPRVARERKLSSVL
                     SVGSGFGGFQSAVVMNRPREKTR"
     aSDomain        2724..3872
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: False"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38250_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.40E-53"
                     /label="IE189_RS38250_PKS_KS.1"
                     /locus_tag="IE189_RS38250"
                     /protein_end="387"
                     /protein_start="4"
                     /score="172.3"
                     /tool="antismash"
                     /translation="VAVTGIGIVAPGGIGVPAFWSLLAAGRTATRAITFFDPAGLRSRI
                     AAECDFDPAAHGLDARDVERCDRYIQFALVAGDEAVRDAGLDLAAENPWRVGVSLGTAV
                     GGTTRLEKDYVLVSNRGQRWDVDHREAAPDLHRAFTPSTLASTVAERFGARGPVQTVST
                     GCTSGLDAVGYAFHTVEEGRADICIAGASDSPISPITMACFDAIKATSPNNDDPAHASR
                     PFDADRDGFVMGEGGAVLVLEELEHARARGAHVYCELGGYATFGNAYHMTGLTSEGLEM
                     ARAIEDALDHARIDAGSIDYVNAHGSGTKQNDRHETAAVKRVLGPHAYDTPMSSIKSMV
                     GHSLGAIGAIELVACVLALANQVVPPTANYETPDPECDLDYVP"
     CDS_motif       2874..2894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38250_0001"
                     /evalue="9.90E+01"
                     /label="PKSI-KS_m4"
                     /locus_tag="IE189_RS38250"
                     /protein_end="61"
                     /protein_start="54"
                     /score="-3.1"
                     /tool="antismash"
                     /translation="FDPAAHG"
     CDS_motif       3393..3431
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS38250_0002"
                     /evalue="5.00E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="IE189_RS38250"
                     /protein_end="240"
                     /protein_start="227"
                     /score="10.2"
                     /tool="antismash"
                     /translation="FDADRDGFVMGEG"
     gene            3977..5227
                     /locus_tag="IE189_RS38255"
                     /old_locus_tag="GCM10010496_77650"
     CDS             3977..5227
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (9-409). E-value:
                     9.6e-27. Score: 85.8. Matches aSDomain:
                     nrpspksdomains_IE189_RS38255_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093: Beta-ketoacyl synthase"
                     /gene_functions="biosynthetic-additional (t2pks) CLF
                     (Score: 551.9; E-value: 1.8e-168)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125752.1"
                     /locus_tag="IE189_RS38255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77650"
                     /product="beta-ketoacyl synthase N-terminal-like
                     domain-containing protein"
                     /protein_id="WP_189928681.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1e-36, bitscore:
                     117.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="t2clf (E-value: 8e-143, bitscore: 466.3,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPHARRAAVTGIGVVAPNGASTETFWKSTREGISVLDRVTREG
                     CEELPLRVAGQVRDFDPSAAIEERFLVQTDRFTHFAMAAADLALDDAQLHRPETDAAPF
                     SVGVVTAAGSGGGEFGQRELQQLWGKGSRFVGPYQSIAWFYAASTGQISIRRGFKGPCS
                     VVAADEAGGLDALAHAARAVRRGTDVIVAGATEAPIAPYSVVCQLGYDELSTVDDPTRA
                     YRPFTTAACGFVPAEGGAMAVVEAESTARARGARVRARLAGHAATFTGASRWEESRQGL
                     AEAVRGALAEAGCAPEEIDVVFADALGVPEADRAEALAITDALGAHGRRVPVTAPKTGI
                     GRGYCAAPLMDVAAAVLTMEHGVIPPTPNVFDICHDLDLVTGRARTAEVRTALVLSRGL
                     MGSNAALVLRHGATDAS"
     aSDomain        4004..5203
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38255_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="9.60E-27"
                     /label="IE189_RS38255_PKS_KS.1"
                     /locus_tag="IE189_RS38255"
                     /protein_end="409"
                     /protein_start="9"
                     /score="85.8"
                     /tool="antismash"
                     /translation="AVTGIGVVAPNGASTETFWKSTREGISVLDRVTREGCEELPLRVA
                     GQVRDFDPSAAIEERFLVQTDRFTHFAMAAADLALDDAQLHRPETDAAPFSVGVVTAAG
                     SGGGEFGQRELQQLWGKGSRFVGPYQSIAWFYAASTGQISIRRGFKGPCSVVAADEAGG
                     LDALAHAARAVRRGTDVIVAGATEAPIAPYSVVCQLGYDELSTVDDPTRAYRPFTTAAC
                     GFVPAEGGAMAVVEAESTARARGARVRARLAGHAATFTGASRWEESRQGLAEAVRGALA
                     EAGCAPEEIDVVFADALGVPEADRAEALAITDALGAHGRRVPVTAPKTGIGRGYCAAPL
                     MDVAAAVLTMEHGVIPPTPNVFDICHDLDLVTGRARTAEVRTALVLSRGLMGSNAALVL
                     R"
     gene            5264..5521
                     /locus_tag="IE189_RS38260"
                     /old_locus_tag="GCM10010496_77660"
     CDS             5264..5521
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (8-77). E-value: 1.6e-12.
                     Score: 39.6. Matches aSDomain:
                     nrpspksdomains_IE189_RS38260_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129: acyl carrier protein"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 77.0; E-value: 2e-24)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009189293.1"
                     /locus_tag="IE189_RS38260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77660"
                     /product="acyl carrier protein"
                     /protein_id="WP_189928682.1"
                     /sec_met_domain="PP-binding (E-value: 1.3e-11, bitscore:
                     35.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRITVEELAGLLKKAAGVTVPPAELTERADGGFDELGVDSLGL
                     LGIVGELENRYGIAMPPDAERCKTPREFLDLVNSTLPTGA"
     aSDomain        5288..5494
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38260_PP-binding.1"
                     /evalue="1.60E-12"
                     /label="IE189_RS38260_PP-binding.1"
                     /locus_tag="IE189_RS38260"
                     /protein_end="77"
                     /protein_start="8"
                     /score="39.6"
                     /tool="antismash"
                     /translation="ELAGLLKKAAGVTVPPAELTERADGGFDELGVDSLGLLGIVGELE
                     NRYGIAMPPDAERCKTPREFLDLV"
     gene            5523..6002
                     /locus_tag="IE189_RS38265"
                     /old_locus_tag="GCM10010496_77670"
     CDS             5523..6002
                     /NRPS_PKS="Domain: Polyketide_cyc2 (3-145). E-value:
                     1.2e-18. Score: 59.8. Matches aSDomain:
                     nrpspksdomains_IE189_RS38265_Polyketide_cyc2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128: cyclase/dehydrase"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C9-C14
                     (Score: 242.2; E-value: 3.7e-75)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433752.1"
                     /locus_tag="IE189_RS38265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77670"
                     /product="SRPBCC family protein"
                     /protein_id="WP_189928683.1"
                     /transl_table=11
                     /translation="MTGHTQNEITIAAPLDLVWEVTNDLENWPRLFSEYASVEILSREG
                     RRTTFRLTMHPDENGTVWSWVSEREPDRDTLTVKARRVETGPFAHMDIHWRYEEVPAGT
                     RMVWTQDFAMKPEAPVDDEWMTDNINRNSKVQLALIRDRIEKTAAERGATPGLTG"
     aSDomain        5532..5957
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS38265_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.20E-18"
                     /label="IE189_RS38265_Polyketide_cyc2.1"
                     /locus_tag="IE189_RS38265"
                     /protein_end="145"
                     /protein_start="3"
                     /score="59.8"
                     /tool="antismash"
                     /translation="HTQNEITIAAPLDLVWEVTNDLENWPRLFSEYASVEILSREGRRT
                     TFRLTMHPDENGTVWSWVSEREPDRDTLTVKARRVETGPFAHMDIHWRYEEVPAGTRMV
                     WTQDFAMKPEAPVDDEWMTDNINRNSKVQLALIRDRIE"
     gene            6023..6355
                     /locus_tag="IE189_RS38270"
                     /old_locus_tag="GCM10010496_77680"
     CDS             6023..6355
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225: Polyketide synthesis cyclase"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C4-C21/C2-C23|C2-C19 (Score: 158.6; E-value: 9.7e-50)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672282.1"
                     /locus_tag="IE189_RS38270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77680"
                     /product="TcmI family type II polyketide cyclase"
                     /protein_id="WP_189928684.1"
                     /transl_table=11
                     /translation="MHQALIVARMAPGSAPDIAKVFEESDRGELPRLVGVHRRSLFQFG
                     DVYMHLIESERDPGPAIAKVVGHPEFRDVSERLASYVSAYDPETWRSPKDAMAQRFYLW
                     EREPAG"
     gene            complement(6456..7484)
                     /locus_tag="IE189_RS38275"
                     /old_locus_tag="GCM10010496_77690"
     CDS             complement(6456..7484)
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_functions="biosynthetic-additional (t2pks) MET C6|C8
                     (Score: 501.7; E-value: 1.8e-153)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433750.1"
                     /locus_tag="IE189_RS38275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77690"
                     /product="methyltransferase"
                     /protein_id="WP_189928685.1"
                     /transl_table=11
                     /translation="MTTAQSAPPPSMRLRELAFGAACAAALRAAARLGVADALGDAPMP
                     VEDIAAAVKTEPRPLRRLMRALSCYGVFTECPDGTFEHTDVSRLLREDDPNSLRAITLW
                     CTEPWTWDAWPLLDEAVRTGGNVVEGLYGKEFFPYLNEDAPESADVFNRAMTTSSVQSA
                     RDVAEFLDLSGSASVADIGGGQGHVVASLLDKYPAMRGTLLDLPRVVENAVPRLLPGGD
                     LAGRARVVPGDVRTAVPVKADVYVIKNILEWDDESTARTLRNVREAGGPGTRVVVIENL
                     VDDTPSMRFSTAMDLLLLLNVGGAKHTTRSMVDRLTEAGLVIDDISPVNPYLHAFDCHV
                     DG"
     gene            complement(7520..8701)
                     /locus_tag="IE189_RS38280"
                     /old_locus_tag="GCM10010496_77700"
     CDS             complement(7520..8701)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672280.1"
                     /locus_tag="IE189_RS38280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77700"
                     /product="nitrous oxide reductase family maturation protein
                     NosD"
                     /protein_id="WP_189928686.1"
                     /transl_table=11
                     /translation="MKKCHIAYLACTAALLGTGLGAAAPDAGHRVHIVHPGESIQKAVD
                     AARPGDTVLVAAGTYRQSVDISTPGLTLRGMGRGTVLRPAAGTATTAPAAGTGTAKPAP
                     KPAKPSKPAKPAKPAKPAKAPKPARSASSCAASGNGICVTGTKDHNVDGVTLASLTVTG
                     FTKNGVYATDADGLTVRRVTAVKNGVWGIATERSLHGEFRDNTARDNGDAGLFLANSVK
                     EEMGATDTDGTVVEHNRLTGNRIGVTVRRLRNLTVADNLLTDNCAAVFVVGDENKPKAG
                     FVTVTENRIEHNNKSCPKTARLDALQGSGIVLTGAEDSVITRNVIKDNAGKSPLSGGIV
                     LFKSFVGTTSDRNRISDNLLRDNSPADLVNTDTGKGNAFEGNDCRSSKPAGLC"
     misc_feature    complement(8695..8709)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.98"
                     /tool="antismash"
     misc_feature    8700..8718
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.26"
                     /tool="antismash"
     misc_feature    8714..8729
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.43"
                     /tool="antismash"
     gene            complement(8814..11114)
                     /locus_tag="IE189_RS38285"
                     /old_locus_tag="GCM10010496_77710"
     CDS             complement(8814..11114)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125746.1"
                     /locus_tag="IE189_RS38285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77710"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_229901627.1"
                     /transl_table=11
                     /translation="MPNNSTAVERRRTPLTGNWPVARRLRAVLLIPVLVALVLGGLRVK
                     RSVDVWQDADDAVRVAELVRAANKYASDAINERDLSVVPLLTDAKGSDTVARARAVTDA
                     DARVFDAAVARMPQTSGLLRRVQLVRAGEAQLAAVRANAFTSRMTGVSTEESYHTVQHP
                     LMELSNELGFGSSNQASFGRTLYAVSLTQAAESLIRSIGTHLLVEDRDRLAPGELAAQL
                     ASFRSYAYLEKVGLQEYAGAGTTEDMTRLRQALAAAEERGRQQSAQAEAQAEAAGRTFT
                     APPGMEEMITAIGDGTPVAELAARGITPESFFAASTLGFDAYRGIQVDLTDTALGNAHD
                     IADRARRDAVVNAALVLASALVAFLLASWFARTMSTGMRRLSAAAIEIAGRRLPELIDQ
                     MSRTDPGEVDTRVAPIPIDTTDEIGEVARAFDLVHREAVRLAGEQARLRGNLNTVFINL
                     SHRGQSLIERQLALITSLEDNETDPEQLENLFRLDHLATRVRRNGENLLVLGGEKPAQQ
                     WDQPLPLVDVVRAASSEVEQYERIRPAGLPEARIEGSVVPDLVHLLAELLENATVFSSP
                     HSQVRVSAERLPDGQIMVEIHDEGIGLEPEDFAKINGKLADPPTVDVEIAQHMGLFVVG
                     RLADRHGINVRLRPSGEESGTISLVMLPASVVRPPENALPDSDTLALALLRTVPGPRFA
                     AALSGGEDPGDAFSGYEAWQDEPAGKRPGDQESPAAGKRPADEKSPAASPASGRARRTS
                     RRAPRRDRRPRTG"
     gene            complement(11236..12381)
                     /locus_tag="IE189_RS38290"
                     /old_locus_tag="GCM10010496_77720"
     CDS             complement(11236..12381)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1113:
                     inner-membrane translocator"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010468976.1"
                     /locus_tag="IE189_RS38290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77720"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_189928696.1"
                     /transl_table=11
                     /translation="MSAGELGSLPVVLVLAVVWITFQSLNPNYLSPRNLSNLSVDIVGT
                     GMIAVGIVFVLLLGELDLSVGSISGLAAAVFAVLNVNHGVPEWLALVIAVLAGTAAGTV
                     QGYSIARTRVPAFVITLAGLLTWNGLMLAVLGDSGTLNLDEDGLVAKLTSYYFTDDAVA
                     YALAAVAAGAVFLVSDHDRRRRRAIGMPHRSLRAIAVRSGSLAVIAFGAAYLLNRFQGL
                     PLALLIFLVVVAGLDLLLRRTRYGRQVYALGGSVEAARRASLGVTWVQTAVLAASGTMA
                     AVGGLFLASRITSVSQSSGSGVLLVNAIAAAVIGGTSLFGGRGTTWSAVLGMLVIQSIA
                     SGMAITDTPPAVQFIITGGVLFAAVVIDSLSRRSHEVHGRA"
     misc_feature    12440..12455
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     gene            complement(12760..13848)
                     /locus_tag="IE189_RS38295"
                     /old_locus_tag="GCM10010496_77740"
     CDS             complement(12760..13848)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180340.1"
                     /locus_tag="IE189_RS38295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77740"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_189928687.1"
                     /transl_table=11
                     /translation="MKARTRDTVAAVTAVCTAVLLAACGADTGDEPRTQGRPSIGLLLP
                     DATTARWETQDRPLLEKRIGELCAECVVDHANAKGDVALQQEQMNSMITKGVDAIVLVP
                     VDARSLGPSVTKAREAGIPVISYDRLAEGPISGYVSFDGVEVGRLQGRALLRAMGDKVP
                     GAEIVMMNGDPSDPNTKSFEEGARSVLGSKVKIGKAYDTLQWRTEAAHMNMAGAIAALG
                     VESIDGVYAANDGLAAGSISALKANKVDPLPPVTGQDAELSALRRIVGGEQYMTVFKPF
                     APEADAGAAMAVAAARGQRLDRLATAEVPTHDGKAVSAVLLTPVSVTADNMRDTVVKSG
                     LHTVRQICTPELRAACVRAGLI"
     gene            13970..16321
                     /locus_tag="IE189_RS38300"
                     /old_locus_tag="GCM10010496_77750"
     CDS             13970..16321
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125740.1"
                     /locus_tag="IE189_RS38300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77750"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_189928688.1"
                     /transl_table=11
                     /translation="MRTCVDRALTFAGATLAAVYAPGAGTRELQLVDTSGKAPSGSAPP
                     ERLPLSEDSPAARAFRTDRSLWLTAGTPLGALPLGTRGSRLGCLVVLGASADGFESEQR
                     HFWERYADAVAALLPPDAGPPRPTPLLDPALRSLRVGFFVLSPDTGLIEADDTVLELVG
                     ITPDDFDGKVDTLLAHALPEDMHALMSVLELAADPFGRRDLEFRVRGPTGEMRWLSLSC
                     RAEADGVDGAQQVLGVVTATSVLRRGGDDVSRIQWLTAALDDAATVRDVGRVVVAALRE
                     PLAADHVAVAALQDDRVMVTALDPPQPDAWPQAWRGEWRTEWPEAPLRALPTLQAALAD
                     GRVDLWPAGTDLEPGLAGIGTGGLAVLPLPAKGQVAGVCLVGWDRPHAFAPEERSLLTA
                     TAALVGQALKRAHAHDAEQELATMLQRSLLPRRLPELPGGTAVARYLPARRGLQVGGDW
                     YDVIALSEDRVALVIGDVQGHSAGAATIMGQMRTAVRAYATEGHPPDVVVSHANRLLVG
                     METDLFATCCYAELDMEEGNVLFVRAGHLAPLLRLPDGTTEEVEVAGGPPLGILAEADF
                     PMTAVELAPGTVLALVTDGLVEASDLPLDEGMRRTRVALAAADPADPGRMADALLGDAG
                     RREDDVAVLLLRYDGMKTRPVKVGWMVWRLPDAVMHARRFTARTLRRWKVPEAADAVLL
                     VVSELVTNALVHTQGPVRLDLILRGDRVRVCVSDSSPRAPAKPVIVDWESTGGRGLLLV
                     EAMSDSFGSVPVAGGKQVWSEITVPGGGAP"
     gene            16318..17418
                     /locus_tag="IE189_RS38305"
                     /old_locus_tag="GCM10010496_77760"
     CDS             16318..17418
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125739.1"
                     /locus_tag="IE189_RS38305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77760"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_189928689.1"
                     /transl_table=11
                     /translation="MRTGRGPVVAVLAAALLTAPLASCGSGEEPDREGFTVGLLLPSRA
                     VPRWEHADRPLIEAQVKKLCPGCRVEYANAENDVTRQREQMISMVTKGAEVLILDAADT
                     RALRSSIQEARRAGVPVIAYDRLAEGPITGYVGFDGIQVGRLQGEALLRAMERRTGSGD
                     ADVVMMNGDPTSPNADSYRKGALSELDGEVRIARAYNTLDWSTQNAHTNMSAAVAALGP
                     DGIDGVLAANDNIAAGVIAALKSAGVTKIPPVTGQDADLDAVRRIVTGEQYMTVYKPFV
                     KEAAAVAEMAVAVGRGEDAGDTATTTVDSPTHKRIPAVLLQPTAVTARDIRRTLIDGGL
                     YTTGQICTRELRAACDRAGITSGPGG"
     gene            complement(17434..17724)
                     /locus_tag="IE189_RS38310"
                     /old_locus_tag="GCM10010496_77770"
     CDS             complement(17434..17724)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125738.1"
                     /locus_tag="IE189_RS38310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77770"
                     /product="zinc-ribbon domain-containing protein"
                     /protein_id="WP_189928690.1"
                     /transl_table=11
                     /translation="MIIFGTKGYLYQLAILTLVCGRCGNPAAHTLRKRVTKFTLFFVPL
                     FPVSTKYATQCTFCGAEQKVTKEQADQLLAQGTGGPGAPAYGSPQQQPYRH"
     misc_feature    17699..17716
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            18005..18985
                     /locus_tag="IE189_RS38315"
                     /old_locus_tag="GCM10010496_77780"
     CDS             18005..18985
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125737.1"
                     /locus_tag="IE189_RS38315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77780"
                     /product="hypothetical protein"
                     /protein_id="WP_189928691.1"
                     /transl_table=11
                     /translation="MPRVPRSAGITAAALALALFASAPAVGDAPVVSDPSVLAHFDLAK
                     GESPENIALASDGSAYLTLSSARQVVRIDRTGRKRVLATLPAVADPHTPIVGAAVVLGI
                     ARARNGTLFVNYATGTGATGIWRVPARGGTARQIAQLPADGFPNGLALDERRGVLYAAD
                     SVRGVVWRVPRTGGRPTAWAAGAALEARNPRPAARVGVNGLRFHRGAVWVSNTNAGTLL
                     RIRVRNNGSAAAIETRATKLYAIDDFAFVERHRDTALAALTGGSEVVLVRPDGTRQVVL
                     ARKDGLSNPTAVAVRGRTAYVPSAAYFTQQDPNLLVARVDQRDRG"
     gene            complement(19105..19821)
                     /locus_tag="IE189_RS38320"
                     /old_locus_tag="GCM10010496_77790"
     CDS             complement(19105..19821)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125760.1"
                     /locus_tag="IE189_RS38320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77790"
                     /product="response regulator transcription factor"
                     /protein_id="WP_189928692.1"
                     /transl_table=11
                     /translation="MASVLIVNDQSLQRVGLRMLLAAEPDLTVVGDTASGAEAVALSAA
                     LRPDVVLLGGVGPGTDDLGTIRRIAHPAAPAHPARPAPPPGPEGPAGRPPRILVLASTG
                     HEGHAYAALRAGAGGFLLQDATPRELTAAVRVVAAGDAVITPGLTRALIETVRHEHPRR
                     PGGRAPGRAAFTERERDVLVAVASGWSNAEIATRLSIAPTTVKSHVSHILAKIGARARV
                     QAVAFAYEYGLVRPAA"
     misc_feature    complement(19916..19927)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     misc_feature    complement(19929..19944)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     gene            complement(20044..21327)
                     /gene="dacB"
                     /locus_tag="IE189_RS38325"
                     /old_locus_tag="GCM10010496_77800"
     CDS             complement(20044..21327)
                     /EC_number="3.4.16.4"
                     /GO_function="GO:0004175 - endopeptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0009002 - serine-type D-Ala-D-Ala
                     carboxypeptidase activity [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="dacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057921.1"
                     /locus_tag="IE189_RS38325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77800"
                     /product="D-alanyl-D-alanine
                     carboxypeptidase/D-alanyl-D-alanine-endopeptidase"
                     /protein_id="WP_229901628.1"
                     /transl_table=11
                     /translation="MRRALVLALALPVTSAALAGPSAFAAGNPTGTTAGNPTAGRTLGA
                     DDRQMVANLEARVVDARLGSKVGGVVLDPDSDTTLWDHDGATALMPASNTKLATATAAL
                     TVLGPDHRFTTRVVYGNGTLTLVGGGDRTLTGADLAELARTAVAGLKAAGLTTVKVAVD
                     DSLFGEPALAEGWNTGYYPDSVAPVRALVVDGHGVQDTSIDAGQAFARQLAAAGVTVDG
                     AVTRAQADPGAFPVARHLSAPLSDIVHTMIKVSDNNIAETLLRTTALAAGRPATFEGGT
                     DVVRQVLSTRYGVPLDNFVIHDGSGLSRANRIPAATLAEILELLTQPRNSATLGSILDG
                     LPVSGEAGSTLGPEWGRFDDVNSRCAVGKVHAKTGTLTGAIALSGLTQGKDGRWKVFAF
                     IENDSTANPSDIKDAMDGLAATVNGCWA"
     misc_feature    21538..21553
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.25"
                     /tool="antismash"
     gene            complement(21561..23150)
                     /locus_tag="IE189_RS38330"
                     /old_locus_tag="GCM10010496_77810"
     CDS             complement(21561..23150)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125762.1"
                     /locus_tag="IE189_RS38330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_77810"
                     /product="hypothetical protein"
                     /protein_id="WP_189928693.1"
                     /transl_table=11
                     /translation="MSGDQYGRFGDTNHHAFPYAPPMPSAPPSPPPAPADGVRAVAVAV
                     LNLSGLGLGYALVRRWVLMVLCWAATAVLLFVALPADPDGVPGVALVLYVAFLAAVAAH
                     GAYVGLRTPLAGLRNAPLALGLGLLLLVGPAGGVVLYDDARDEATQQMLLDRLDEADRL
                     VRAAGDRAFTSARADYRKALDAYADLRSDHPGSRAAEQVPARMKAFYTTVGAPYAQGKY
                     CEAVEPLKYLRTVPKSLPGTDLGALRTWPDDRLATSLYECASTALTAGEATWASQYGEL
                     LSTFPRSEQAAKVEPAVAAAVVRTEKDLGGAEPCSAVQRLTTLGTQIDGLDAGQSDAGA
                     ALDRDALRAAASADTGAYTCGVDQYRDGDFDSAQKTMTDYASAHKTAKNAALAKKIAIA
                     AEVAQTVPAAGKKLPTTRTGGSISVTVQNDSPDEVTVLYTGPVTGSFTLKACGSCKAYS
                     LGSTLNPSFKPCPSGKNYPERTISLPVGTTYFLHKPKGDSLATPASDTAKLQSGYIYTE
                     CAYTTQSLGSGL"
ORIGIN
        1 gactcggcat cctcgccgtc gccggcaccg gcctctacgc cctgcgccgc aagaagagcg
       61 ccccgggcgc ggcctgaccc gtgccggacg cgatagcgcg gccgcggccg ccacgcatgc
      121 ccccgcgtgg cggcccggcc cgctccccgt gctctgtccg ctccgctgcc gcgcccgagt
      181 gaggtggtcc tcccatggca gttcccccct cttccgcccc ttccccctcc gaccccgccg
      241 gcgagccgcc gcccgccgag gagggacggt cccgcaccgg tctgacgatg atctgcgccg
      301 cggccgcggc gctcctggcg ctgaacctgt tcggcggcaa cgacacctcg tccggcgccc
      361 ccagtccgcc gcacgccccg cccgcggccg gatcgctccc cgccgcctcg ggcgcgggcg
      421 cagcgcaagc ggacggcggg gccccggcgg gcaagcacct gccgcgctcc aggcccgtgc
      481 ggctgctcat cccgaagatc gcggtcgacg cccccttcac cgacctcgcc atcggggccg
      541 acggacggct cgaacccccg ccggccgccg acgtcaacct cgtcggctgg cacgccgccg
      601 gagtctcccc cggcgaggcg ggcaccgcga tcatcgccgg gcacgtcgac accaagacgt
      661 cccccgccgt cttcgcggga ctcagcggcc tgaccaaggg cgacggcttc caggtcctgc
      721 gggccgacgg cagcaaggcg tccttccgcg tcgacgacgt ggagaccttc gacaaggccg
      781 acttccccga cgaacgcgtg tacgccgaca ccgcgcaggc gcaggtgcgg ctcatcacct
      841 gtgcgggcaa ctacgacagg cgcgtcaagg actacacgga caacctggtc gtcttcgccc
      901 atctcgtctg acgtccgggc gcccggtcac ccgcgtagtt catccgagtc gcgcgctcgc
      961 ggggacgggc acaggatcga ggcacgctga cgtcgcatca ccgcggccga cgttcacttc
     1021 ccccctccgc gaaggagatg tgcgcaggat gaccaccacg tccgaacgtg ttgccggttc
     1081 gcgggcgcga caggcgtcac aacgtgtctc ccagtccgtg ttcgacggct cccggctccg
     1141 cgtcgtcctt ctggtcgacg tctacgacgg ggcccagcag cagttcctcg aggcgtacga
     1201 acagctctgc aaccaggtcg cgtccgtccc cggacatgtc agcgaccaac tgtgccagtc
     1261 catcgagaac ccctcccagt ggctcatcac cagcgagtgg gagagcgccc cgccgttcct
     1321 cgcctgggtc aacagcgagg agcacgtggc gatggtggag ccgctccaca gctgcgtgcg
     1381 cgacacccgc tcgctgcgct tccacgtcgt gcgcgagacc ggcggcccgg cgacgggcgc
     1441 cgaccgcgcc gagcgcaggc tccagtcgtc cccccggatc ggcgacgggg tgatccgcca
     1501 cgcgctcacc ttcaccgtca agccgggcag cgaggagatc gtcgcgaaga tcctcgccga
     1561 ctacgcctcg cccgagccgc aggtcgacga caccacccgg ctgtgccgca cctcgctgtt
     1621 catgcacggc aaccgggtgg tccgcgccat cgaggtgcgc ggcgacctgc tctccgcgct
     1681 gcgccacgtc tcccggcagc ccgaggtgcg ggccgtcgag gaggccatca acccccatct
     1741 ggagcaggac cgggacctga acgaccccga gtccgcccgg gtcttcttca cccgtgccgc
     1801 gctgccggcc gtgcaccacg tgacggcgga gcggatggac gcgcaggccg agcggtacgc
     1861 cctgtactac ccgacccggg cggacggcgg catgaagctg gccgagctgc tcgcccggca
     1921 ggacgaggcg gcggccgacg acccgcgcag cccggtcctg cgcagcacga tcttccagcg
     1981 cgacgactgc gtcgtacggc tgatcgacgt gcgcggcgga ctcgaggccg ccgaccccgg
     2041 acaggccctc ggtctgtccg accccggaca ggtggccgag ctgacgacgc tcgaggacga
     2101 cgccgccggt gcgtccgcgt cgaaggacgg ccgtctcgcg cgcttcctcg aacgggcgcg
     2161 catggatctc gtcaccgacc gccggtcgcc cgacgcctga ttcgtcatcg gtgcgggggg
     2221 gcggtgcccc gcccctccca cgccggtgca gtacttcatc ggaggaacgt cgtgatcact
     2281 tcccgtcaca gaatcgtgga tctcagcgag gtcgagccca acacccggcg cggcggcgac
     2341 ctgcgcgcca tgctcacccc cgccacggtc ggcgccacca gcggtttcat gggcctcgcc
     2401 ctcatccagc ccggcgaccg catcgctgag cactaccacc cgtactccga ggagttcgtg
     2461 tacgtcgtgt gcgggcagct cgaggtggac ctggacggcg agccgcaccc gctccagccg
     2521 gagcaggggc tgctgatccc gctcaacgtg cgccaccgct tccgcaacgt cggcaaggtg
     2581 gaggcccgga tggtcttcca cctcggcccg ctggccccga gcccgccgct gggccacgtc
     2641 gacaccgagg agaccgtcgc cgagcccgtg gtcgtcgggg ccgaggcggc cggtggacgt
     2701 caggtccggt catgacgaga cgagtggcgg tcaccggcat aggcatcgtc gccccgggcg
     2761 gcataggcgt accggcgttc tggagccttc tggcggccgg acgcacggcg acgcgtgcca
     2821 tcacgttctt cgacccggcc ggtctgcgct cacggatcgc cgccgagtgc gacttcgacc
     2881 cggcggccca cgggctggac gcgcgcgacg tcgaacgctg cgaccgctac atccagttcg
     2941 ccctggtcgc gggcgacgag gcggtacggg acgccggtct cgacctggcc gccgagaatc
     3001 cctggcgggt cggcgtctcc ctgggcacgg cggtcggcgg caccacccgg ctggagaagg
     3061 actacgtcct ggtcagcaat cgcggtcagc gctgggacgt cgaccaccgc gaggcggcgc
     3121 cggacctgca ccgcgcgttc acgcccagca ccctcgcgtc cacggtggcg gagcggttcg
     3181 gggcgcgcgg cccggtgcag accgtctcca cgggctgcac ctccgggctc gacgccgtcg
     3241 gatacgcctt ccacaccgtg gaggagggcc gggccgacat ctgcatcgcc ggcgcctcgg
     3301 actcgccgat ctccccgatc accatggcgt gcttcgacgc gatcaaggcc acctcgccga
     3361 acaacgacga cccggcccac gcctcacgtc ccttcgacgc cgaccgtgac gggttcgtca
     3421 tgggcgaggg cggcgccgtg ctcgtactgg aggagctgga gcacgcgagg gcccgcggcg
     3481 cccacgtcta ctgcgagctc ggcgggtacg ccacgttcgg caacgcgtac cacatgaccg
     3541 gcctgaccag cgagggactg gagatggccc gggccatcga ggacgccctc gaccacgccc
     3601 ggatcgacgc aggctcgatc gactacgtca acgcgcacgg gtcgggcacc aagcagaacg
     3661 accgtcacga gaccgccgcg gtgaagcggg tcctgggccc gcacgcctac gacaccccca
     3721 tgagctccat caagtcgatg gtgggtcact ccctcggcgc gatcggagcg atcgaactcg
     3781 tcgcctgcgt actggccctg gccaaccagg tggtaccgcc gaccgcgaac tacgagaccc
     3841 ccgaccccga gtgcgacctg gactacgtcc cgcgcgtggc ccgcgagcgc aagctctcca
     3901 gcgtcctttc ggtgggcagc gggttcggcg gcttccagtc cgcggtggtc atgaaccggc
     3961 cgagggagaa gacacgatga gcgaacccca tgctcggcgc gcggcggtca cgggaatcgg
     4021 tgtggtcgcg cccaacggag ccagtaccga gacgttctgg aagtccaccc gggagggcat
     4081 cagcgtcctc gaccgggtga cccgcgaggg ctgtgaggag ctgccgctgc gggtggcggg
     4141 ccaggtgcgc gacttcgacc cgtcggccgc gatcgaggag cgcttcctgg tccagaccga
     4201 ccggttcacg cacttcgcga tggccgcggc cgacctcgcg ctggacgacg cccagctgca
     4261 ccggcccgag accgacgccg cgccgttctc cgtgggcgtg gtcaccgcgg cgggctccgg
     4321 cggcggcgag ttcggacagc gcgagctcca gcagctgtgg ggcaagggca gccggttcgt
     4381 cggcccgtac cagtccatcg cctggttcta cgccgccagc accggccaga tctccatccg
     4441 ccgcggcttc aagggaccct gctcggtcgt cgccgccgac gaggccggcg gtctggacgc
     4501 cctcgcgcac gcggcgcggg ccgtgcggcg cggcaccgac gtgatcgtgg ccggggcgac
     4561 cgaggccccg atcgcgccgt actcggtggt gtgccagctc ggctacgacg agctgagcac
     4621 ggtcgacgac ccgacccgcg cctaccgtcc gttcaccacc gccgcctgcg ggttcgtgcc
     4681 cgccgagggc ggcgccatgg cggtggtgga ggcggagtcc acagcccggg cgcgtggcgc
     4741 gcgggtgcgg gcccggctgg ccggacacgc ggcgaccttc accggggcct cccgctggga
     4801 ggagtcgagg caagggctcg ccgaggccgt acgcggagcc ctcgcggagg ccggctgcgc
     4861 cccggaggag atcgacgtgg tcttcgccga cgccctcggg gtcccggagg cagaccgggc
     4921 cgaggcgctg gcgatcaccg acgccctcgg cgcccacggc aggcgggtgc ccgtcaccgc
     4981 gccgaagacc gggatcggcc gcggctactg cgcggcgccc ctgatggacg tggcggcggc
     5041 ggtgctcacg atggagcacg gcgtgatccc gcccaccccg aacgtgttcg acatctgcca
     5101 cgacctcgat ctcgtgaccg gccgggcccg taccgccgag gtgcgcacgg cactggtcct
     5161 gagccgggga ctcatggggt cgaacgcggc gctggtgctg cggcacggcg ccaccgacgc
     5221 ctcgtgacga ggtgtcacgg agcagcagag gaagggaacg gcaatgacgg accgcatcac
     5281 tgtggaagag ctggctggtc tgctgaagaa ggccgcgggg gtcaccgtcc cgccggccga
     5341 gctcacggag cgggcggacg gcggcttcga cgaactgggt gtcgactcgc tgggtctgct
     5401 cggcatcgtc ggcgagctgg agaaccggta cggcatcgcg atgccgccgg acgccgagcg
     5461 ctgcaagacc cccagggagt tcctcgacct ggtgaacagc accctgccga caggagcctg
     5521 acatgaccgg acacacgcag aacgagatca ccatcgcggc acccctggac ctggtctggg
     5581 aggtgaccaa cgacctggag aactggcccc gcctgttcag cgagtacgcc tccgtggaga
     5641 tcctctcccg cgaggggcgc cgtacgacgt tccggctgac catgcacccg gacgagaacg
     5701 gcacggtgtg gagctgggtc tcggagcgcg agccggaccg cgacacgctc accgtcaagg
     5761 cccgcagggt cgagacgggg ccgttcgccc acatggacat ccactggcgg tacgaggagg
     5821 taccggccgg cacgcggatg gtctggacgc aggacttcgc gatgaagccc gaggcgccgg
     5881 tcgacgacga gtggatgacc gacaacatca accgcaactc caaggtccag ctggccctga
     5941 tccgggaccg catcgagaag accgccgccg agcgcggcgc cacccccggt ctgaccggct
     6001 gacccggacg gaggacaacc ccatgcacca ggcactgatc gtcgcccgga tggccccggg
     6061 atcggccccc gacatcgcca aggtgttcga ggagtccgac cggggggagc tgccgcggct
     6121 cgtcggggtg caccggcgca gcctcttcca gttcggcgac gtctacatgc acctgatcga
     6181 gtccgagcgc gatccgggac ccgccatcgc caaggtcgtc gggcaccccg agttccgtga
     6241 cgtcagcgag cggctggcct cctacgtcag cgcgtacgac cccgagacct ggcgttcccc
     6301 gaaggacgcc atggcgcagc gcttctacct ctgggagcgc gagccggccg gctgaccgca
     6361 gcctgccctc accggtcgcc ggacccgcca cgctgcgggc ccggcgaccg gtgtttcggg
     6421 gggaagagct ctcggtgatc cgggtcgggt ccggatcagc cgtccacgtg gcagtcgaac
     6481 gcgtgcaggt acgggttgac gggactgatg tcgtcgatga ccaggccggc ctcggtcagc
     6541 cggtccacca tgctgcgggt ggtgtgcttg gccccgccga cgttgaggag cagcagcagg
     6601 tccatcgcgg tgctgaaccg catcgagggg gtgtcgtcga cgaggttctc gatgaccacg
     6661 acccgggtgc ccgggccgcc cgcctcgcgg acgttgcgca gcgtgcgggc ggtgctctcg
     6721 tcgtcccact ccaggatgtt cttgatgacg tagacgtcgg ccttcaccgg gacggccgtg
     6781 cggacgtcgc cgggcaccac gcgcgcgcgg ccggcgaggt cgccgcccgg gagcaggcgc
     6841 ggcaccgcgt tctccacgac ccggggcagg tcgagcagcg tgccgcgcat cgcggggtac
     6901 ttgtccagca ggctggccac cacgtgcccc tggccgccgc cgatgtccgc gaccgaggcg
     6961 ctccccgaca ggtcgaggaa ctccgcgacg tcgcgtgccg actgcacgct ggaggtggtc
     7021 atggcgcggt tgaagacgtc ggccgactcc ggggcgtcct cgttgaggta ggggaagaac
     7081 tccttgccgt agaggccttc caccacgttg ccgccggtgc gcaccgcctc gtcgagcagc
     7141 ggccaggcgt cccaggtcca cggctcggtg caccacaggg tgatggcccg caggctgttg
     7201 gggtcgtcct cgcgcagcag ccgggagacg tcggtgtgct cgaacgttcc gtccgggcac
     7261 tcggtgaaga cgccgtagca ggacagggcc cgcatcaggc gccgcagcgg gcgcggttcg
     7321 gtcttcaccg cggccgcgat gtcctccacc ggcatggggg cgtcgccgag ggcgtcggcg
     7381 acgcccagcc gggcggcggc gcgcagggcg gcggcgcagg ccgccccgaa ggcgagttca
     7441 cgcagccgca tggacggcgg aggggcggac tgggcggtcg tcatgggccg tcttccttcc
     7501 ttctctgggt tccgggtgtt cagcacaggc ccgcgggctt cgacgaccgg cagtcgttgc
     7561 cctcgaaggc gttgcccttg ccggtgtccg tgttgaccag gtcggcgggg gagttgtcgc
     7621 gcagcaggtt gtcgctgatc cggttccggt cgctggtcgt gccgacgaag ctcttgaaca
     7681 gcacgatgcc gccggacagc ggggacttgc cggcgttgtc cttgatcacg ttccgggtga
     7741 tcacgctgtc ctcggcgccg gtcaggacga tgccggaccc ctggagggcg tccagccggg
     7801 ccgtcttcgg gcaggacttg ttgttgtgct cgatgcggtt ctcggtcacg gtcacgaaac
     7861 cggccttcgg cttgttctcg tcgccgacga cgaacaccgc ggcgcagttg tccgtcagga
     7921 ggttgtccgc gacggtgagg ttgcgcagcc tgcgcacggt gacgccgatc cggttgcccg
     7981 tcagccggtt gtgctcgacc accgtgccgt cggtgtcggt ggcgcccatc tcctccttga
     8041 ccgagttggc gaggaagagc cccgcgtcac cgttgtcgcg ggcggtgttg tcgcggaact
     8101 cgccgtggag ggagcgttcc gtggcgatgc cccacacgcc gttcttcacc gcggtgaccc
     8161 tgcgcacggt cagcccgtcg gcgtccgtgg cgtagacgcc gttcttggtg aagccggtga
     8221 ccgtcaggga cgcgagggtg acgccgtcga cgttgtggtc cttcgtgccc gtgacgcaga
     8281 tgccgttgcc gctcgcggca caactgctcg cggacctggc gggcttggga gccttggcgg
     8341 gcttggcggg cttggcgggc ttggccggct tggagggctt cgccggtttg ggggcgggct
     8401 tcgcggtgcc ggtcccggcg gccggggcgg tggtggcggt gcctgccgcg ggccggagca
     8461 ccgtgccgcg gcccatgccg cgcagggtga gtccgggcgt gctgatgtcg acgctctggc
     8521 ggtacgtgcc ggccgccacc aggacggtgt cgcccggccg cgcggcgtcc accgccttct
     8581 ggatcgactc gccggggtgg acgatgtgga cccggtgtcc ggcgtccggc gcggcggcgc
     8641 cgagtcccgt cccgaggagc gcggccgtgc aggccagata cgcgatatgg catttcttca
     8701 tattgtgcac ggtatgaccg tatggttcgg taaccgccgg gataggccgt ccggcggcgt
     8761 gtcccgggcc ggccgcgtgc cgcaccggtc ggcgcggaca cgccgccgcg gcgtcagccg
     8821 gtacggggac ggcggtcgcg ccggggcgcc cgccgggacg tcctgcgcgc gcggccggac
     8881 gcgggcgagg cggccggtga tttttcgtcg gccggccgct tccccgccgc cggtgactcc
     8941 tggtcgcccg gccgcttccc cgccggctcg tcctgccatg cctcgtaccc cgagaaggcg
     9001 tcccccgggt cctcgccgcc cgacagggcg gccgcgaacc ggggcccggg gacggtcctg
     9061 agcagggcca gcgccagggt gtcggagtcg ggcagcgcgt tctccggggg ccggaccacc
     9121 gaagcgggca gcatgacgag ggagatggtg ccggactcct cgcccgaggg ccgcagccgg
     9181 acgtttatgc cgtgccggtc ggcgagccgg cccaccacga acagccccat gtgctgggcg
     9241 atctcgacgt ccaccgtcgg cggatcggcg agcttgccgt tgatcttcgc gaagtcctcg
     9301 ggctccaggc cgatgccctc gtcgtggatc tcgaccatga tctggccgtc ggggagccgc
     9361 tcggcgctca cccgcacctg cgagtgcggc gacgagaaca cggtcgcgtt ctccagcagt
     9421 tccgcgagca ggtgcacgag gtcgggcacg acggagccct cgatccgcgc ctcgggcaga
     9481 ccggccggcc ggatgcgttc gtactgctcc acctccgagg aggcggcacg gacgacgtcc
     9541 accagcggca gcggctggtc ccactgctgg gcgggcttct cgccgccgag caccaggagg
     9601 ttctcgccgt tgcggcggac ccgggtggcg aggtggtcca gccggaagag gttctccagc
     9661 tgctcggggt cggtctcgtt gtcctccagg ctggtgatca gggccagctg ccgttcgatc
     9721 agggactgcc cgcggtgcga gaggttgatg aagacggtgt tcaggttgcc gcgcagccgc
     9781 gcctgctcgc cggccagccg gacggcctcg cggtggacga ggtcgaaggc ccgggcgacc
     9841 tcgccgatct cgtcggtggt gtcgatcggg atcggcgcga cccgggtgtc cacctcgccc
     9901 gggtcggtcc gggacatctg gtcgatgagc tcgggcagcc tgcggcccgc gatctcgatg
     9961 gcggcggcgc tgagccggcg catcccggtg ctcatcgtcc gggcgaacca ggaggccagc
    10021 aggaaggcca cgagtgccga ggccaggacg agtgccgcgt tcacgacggc gtcccggcgt
    10081 gcccggtcgg cgatgtcgtg ggcgttgccg agcgcggtgt cggtgaggtc cacctggata
    10141 ccccggtagg cgtcgaagcc cagggtggag gcggcgaaga aggactcggg ggtgatgccc
    10201 cgcgcggcga gttccgcgac cggtgtgccg tcgccgatcg cggtgatcat ctcctccatg
    10261 ccgggcgggg cggtgaacgt gcgtcccgcc gcctcggcct gcgcctcggc ctgcgcgctc
    10321 tgctgcctgc cccgctcctc ggcggcggcc agtgcctgcc gcagcctggt catgtcctcg
    10381 gtggtgccgg cgcccgcgta ctcctggagt cccaccttct ccaggtaggc gtacgagcgg
    10441 aaggaggcga gctgggcggc cagctcgccg ggagccagcc ggtcgcggtc ctccacgagc
    10501 agatgcgtgc cgatggaccg gatcagcgac tcggccgcct gcgtcaggga caccgcgtag
    10561 agcgtgcggc cgaagctcgc ctggttgctg ctgccgaagc ccagttcgtt ggagagctcc
    10621 atcagggggt gctggaccgt gtggtagctc tcctccgtgc tcaccccggt catccgggag
    10681 gtgaaggcgt tggcccgtac ggcggcgagc tgtgcctcgc ccgcccggac cagctggacg
    10741 cgccgcagca ggccgctggt ctgcggcata cgggcgaccg ccgcgtcgaa cacccgggcg
    10801 tccgcgtcgg tgacggcccg ggcccgggcg accgtgtccg accccttggc gtccgtcagc
    10861 agggggacga ccgacaggtc gcgctcgttg atcgcgtcgc tcgcgtactt gttcgccgcc
    10921 cggaccagtt cggcgacgcg gaccgcgtcg tcggcgtcct gccagacgtc gaccgagcgt
    10981 ttcacccgca ggccgccgag cacgagggcg acgagcacgg ggatcagcag gacggcccgg
    11041 agccgtctgg ccaccggcca gttgccggtg aggggcgttc ttcgtctctc gaccgcggtg
    11101 gagttgttcg gcactgtcga cctatcgcct ctggagcgcc tcgcgcgtga gcgcccgtac
    11161 ccctcactac gcggcgccgg tgccaaggcg ttcaaaagtg gtgcaacttt cacctaagtg
    11221 ggtcgggttt ccccgtcagg cccgtccgtg cacctcgtgg gagcgccggg acagcgagtc
    11281 gatgacgacc gcggcgaaga gcaccccgcc ggtgatgatg aactgcacgg ccgggggagt
    11341 gtccgtgatc gccatgcccg aggcgatcga ctggatgacc agcatgccga gcaccgccga
    11401 ccaggtcgtg ccacgcccgc cgaacaggct cgtgccgccg atgacggccg ccgcgatggc
    11461 gttgaccagc agcacgccgg accccgagct ctggctcacc gaggtgatgc gcgaggccag
    11521 gaacaggcct ccgacggcgg ccatcgtgcc cgaggccgcg agcaccgccg tctgcaccca
    11581 cgtcacgccg agactggcgc gccgggccgc ctcgacgctg ccgccgagcg cgtagacctg
    11641 ccgtccgtag cgggtgcggc gcagcaggag gtcgaggccg gccaccacca cgaggaagat
    11701 cagcagggcg agcggcaggc cctggaaccg gttgaggaga taggcggcgc cgaacgcgat
    11761 caccgcgagc gacccggagc gcacggcgat ggcccgcagc gaacggtgcg gcatgccgat
    11821 ggctcttcgc cgtctgcggt cgtggtcgct gacgaggaac accgcccccg cggcgaccgc
    11881 cgccagggcg taggccaccg cgtcgtcggt gaagtagtag ctcgtcagct tggcgaccag
    11941 gccgtcctcg tcgaggttga gggtgccgct gtcgccgagc acggccagca tgaggccgtt
    12001 ccaggtgagc agcccggcga gggtgatcac gaacgccggt acccgggtgc gcgcgatgga
    12061 gtagccctgg acggtccccg ccgcggtgcc cgccaggacc gcgatgacga gcgccagcca
    12121 ttccggcacc ccgtggttga cgttcagcac ggcgaagacg gccgcggcga ggccgctgat
    12181 cgagccgacg gacagatcga gctcgccgag cagcaggacg aagacgatgc cgacggcgat
    12241 catccccgtg cccacgatgt ccacgctgag gttggacagg ttgcggggcg agaggtagtt
    12301 cgggttgagg gactggaagg tgatccagac gaccgccagg accaggacga cgggaagcga
    12361 acccagctcg cccgcgctca tccggtgccg cagggccgtc gacgcgctcc gcacggcacg
    12421 ggtggcagcc cgcgcgccgg tcaccacctc gtctcccggg cgcccggccc gcggggcgca
    12481 ccgcgcacgg cgccggcggc ggtccggacg gtccgctccc ggggcgcggt ccccctgcgg
    12541 ctgccgcggc cgtggatctc ggccgggccg cgcctcctgt gcgcggtccg cgccgccggt
    12601 gaggggggat ccggcacgga aaccatctcc ttcccggggc gtcgggccgt gcggcgcggg
    12661 ccgtgccacg agagccgtgc ccaaggtcca tgctgcgaca ggtcgcggcg gcgcgcagtc
    12721 ggtgcggtgc ccggcggggc cggtcgcggc cggccggggt cagatcagtc cggcccggac
    12781 gcaggcggcc cgcagctcgg gggtgcagat ctgccggacg gtgtgcaggc cgctcttgac
    12841 caccgtgtcc cgcatgttgt ccgcggtcac cgacaccggg gtgagcagga cggcggagac
    12901 cgccttcccg tcgtgcgtcg gcacctcggc ggtggccagg cggtccaggc gctgcccgcg
    12961 ggccgcggcc acggccatgg cggcgccggc gtcggcctcc ggcgcgaacg gcttgaagac
    13021 ggtcatgtac tgctcgccgc cgacgatgcg ccgcagcgcc gagagttcgg cgtcctgtcc
    13081 ggtgaccggc ggcagcgggt ccaccttgtt cgccttgagg gcggagatgc tcccggccgc
    13141 gaggccgtcg ttggccgcgt agaccccgtc gatggactcg acgccgagcg ccgcgattgc
    13201 gccggccatg ttcatgtgcg ccgcttccgt acgccactgg agggtgtcgt aggccttgcc
    13261 gatcttcacc ttcgagccga gcaccgaccg ggcaccctcc tcgaacgact tggtgttcgg
    13321 gtcgctggga tcaccgttca tcatgacgat ctcggcgccg ggcaccttgt cgcccatcgc
    13381 ccggagcagg gcccggccct ggagcctgcc gacctccacc ccgtcgaagg agacgtaacc
    13441 cgagatgggc ccctcggcga gccggtcgta ggagatgacg gggatgcccg cctcgcgcgc
    13501 cttggtgacc gaggggccca gggagcgggc gtccacgggc acgagcacga tggcgtcgac
    13561 gcccttcgtg atcatcgagt tcatctgttc ctgctggagc gccacatcac ccttggcgtt
    13621 ggcgtggtcg accacgcact cggcgcacag ttcgccgatc ctcttctcca gcaggggtct
    13681 gtcctgggtc tcccagcggg ccgtggtggc gtccggcagc agcagaccga tgctcggccg
    13741 gccctgcgtc cgcggctcgt cgccggtgtc cgccccgcag gccgccagga ggaccgcggt
    13801 gcagaccgcg gtcaccgcgg cgaccgtgtc ccgtgtacgg gccttcatgg gtggtacctg
    13861 ccgtagacga caataaggtg ggaatgttcg attgatccgt ctatgcgatt ctggtcggta
    13921 ggtgccccga tctcaacctg tcggcacctg cggcaggacg ggaggtacgg tgcggacctg
    13981 cgtcgaccgg gccctgacct tcgccggagc cacactggca gcggtctacg cacccggggc
    14041 cgggacaagg gaactccagt tggtcgacac gtccggaaag gctccttccg gatcggcgcc
    14101 gccggagcgc ctgcccctgt ccgaggactc gcccgcggcc cgcgccttcc gcaccgaccg
    14161 ctccctgtgg ctgaccgccg gcaccccgct cggcgcgctg cccctcggca cccggggcag
    14221 caggctcggc tgcctcgtcg tcctcggggc ctccgccgac ggcttcgagt cggagcagcg
    14281 ccacttctgg gagcggtacg ccgacgccgt cgccgcgctc ctgccgccgg acgccggccc
    14341 gccgcggccg accccgctgc tggacccggc cctgcgcagt ctgcgcgtcg gcttcttcgt
    14401 cctctccccg gacaccggac tgatcgaggc cgacgacacc gtgctcgaac tggtcggcat
    14461 cacaccggac gacttcgacg gcaaggtcga caccctgctc gcccacgccc tccccgagga
    14521 catgcacgcc ctgatgtcgg tcctcgaact cgccgccgac cccttcggcc ggcgcgacct
    14581 ggagttccgg gtccgcggcc ccacggggga gatgcgctgg ctcagcctga gctgccgggc
    14641 ggaggccgac ggcgtggacg gagcgcagca ggtcctcggc gtggtgacgg ccacctcggt
    14701 cctgcggcgc gggggcgacg acgtctccag gatccagtgg ctgacggcgg ccctcgacga
    14761 cgcggccacg gtccgtgacg tcggccgcgt cgtcgtcgcc gccctgcgcg aaccgctggc
    14821 cgccgaccac gtcgccgtcg ccgcgctcca ggacgaccgg gtcatggtca ccgcgctcga
    14881 cccgccgcag cccgacgcgt ggccgcaggc gtggcgcggc gagtggcgca cggaatggcc
    14941 cgaggcgccc ctgcgcgccc tgcccaccct ccaggcggcc ctggcggacg gccgggtgga
    15001 cctgtggccc gcgggaaccg acctcgagcc cggtctcgcc gggatcggca ccgggggact
    15061 ggccgtcctt ccgctgcccg ccaagggcca ggtggccggg gtgtgcctgg tcggctggga
    15121 caggccgcac gcgttcgcgc ccgaggaacg ctccctgctc accgccacgg ccgccctcgt
    15181 cggccaggca ctcaagcgcg cccacgcgca cgacgccgag caggaactcg cgaccatgct
    15241 ccagcgcagc ctgctgcccc gccggctgcc cgaactgccc ggcgggacgg ccgtcgcccg
    15301 ctatctgccc gcccggcgcg gactccaggt gggcggcgac tggtacgacg tgatcgccct
    15361 gtcggaggac cgggtcgccc tggtcatcgg ggacgtccag ggccacagcg ccggagccgc
    15421 gacgatcatg gggcagatgc gtacggcggt ccgcgcctac gccaccgagg gccatccgcc
    15481 cgacgtggtc gtctcgcacg ccaaccggct cctcgtcggc atggagaccg acctcttcgc
    15541 cacctgctgc tacgccgaac tcgacatgga ggagggcaac gtcctcttcg tccgggccgg
    15601 gcacctcgcc cccctgctgc ggctgcccga cggcaccacc gaggaggtcg aggtggcggg
    15661 cggccctccg ctcggcatcc tggcggaggc cgacttcccc atgacggccg tcgaactggc
    15721 ccccggcacg gtcctcgccc tggtcaccga cgggctggtc gaggcctccg acctgccgct
    15781 cgacgagggc atgcgccgca cccgcgtcgc gctcgccgcg gccgaccccg ccgacccggg
    15841 ccggatggcc gacgccctcc tcggcgacgc cggccgccgg gaggacgacg tggcggtgct
    15901 cctgctgcgc tacgacggca tgaagacccg gccggtcaag gtcggctgga tggtgtggcg
    15961 gctgcccgac gccgtcatgc acgcccgccg cttcaccgcc cgcacactgc gtcgctggaa
    16021 ggtccccgag gcggccgacg cggtgctgct cgtggtctcc gaactcgtca ccaacgcgct
    16081 ggtgcacacc cagggcccgg tgcgcctgga cctgatcctg cgcggcgacc gggtacgggt
    16141 ctgcgtcagc gactcctcgc cgcgcgcgcc cgccaaaccg gtgatcgtgg actgggagtc
    16201 gaccggcggc cggggattgc tgctggtcga ggcgatgtcg gactccttcg gctccgtgcc
    16261 cgtggccggc ggcaaacagg tgtggagcga gatcaccgta ccgggaggag gcgcaccgtg
    16321 aggaccggcc gcgggcccgt cgtcgcggtg ctcgccgcgg cgctcctgac ggcacccctc
    16381 gcctcctgcg gctccggcga ggaaccggac cgggagggct tcaccgtcgg cctgctgctg
    16441 ccgagccgcg cggtgccccg ctgggaacac gccgaccggc cgctcatcga ggcccaggtg
    16501 aagaagctgt gccccggctg ccgggtggag tacgccaacg ccgagaacga cgtcacccgg
    16561 cagcgggagc agatgatctc catggtcacc aagggggccg aggtcctgat cctcgatgcc
    16621 gccgacaccc gggcgctgcg ctcctccatc caggaggccc gccgggcggg cgtgccggtc
    16681 atcgcctacg accgcctcgc cgagggcccg atcaccggct acgtcgggtt cgacggcatc
    16741 caggtcggca ggctccaggg ggaggcgctg ctgcgggcca tggagcggcg caccgggagc
    16801 ggcgacgcgg acgtcgtcat gatgaacggc gatccgacca gcccgaacgc cgactcgtac
    16861 cgcaagggcg cgctctccga gctcgatggc gaggtccgca tcgcccgcgc ctacaacacg
    16921 ctcgactgga gcacccagaa cgcccacacc aacatgtccg ccgccgtcgc ggccctcggc
    16981 ccggacggga tcgacggggt gctggcggcc aacgacaaca tcgccgcggg cgtcatcgcc
    17041 gcgctcaaga gcgccggggt cacgaagatc ccgcccgtca ccggccagga cgccgacctg
    17101 gacgcggtgc ggcggatcgt caccggcgag cagtacatga cggtctacaa gccgttcgtg
    17161 aaggaggccg ccgcggtggc cgagatggcc gtcgccgtgg ggcggggcga ggacgccggc
    17221 gacaccgcca cgacgaccgt cgacagcccc acccacaagc gcatccccgc ggtgctgctc
    17281 cagccgaccg cggtgacggc ccgggacatc cggcggaccc tgatcgacgg cggcctgtac
    17341 accacgggcc agatctgcac ccgtgagctc agggccgcct gcgaccgggc cgggatcacc
    17401 tccgggcccg gcgggtgaac ggcccgcgga tcctcagtgc cggtacggct gctgctgcgg
    17461 cgagccgtac gccggggcgc cggggccgcc cgtgccctgc gccaggagct ggtcggcctg
    17521 ctccttggtc accttctgct ccgcgccgca gaaggtgcac tgggtcgcgt acttcgtgga
    17581 gaccgggaac aggggcacga agaacagcgt gaacttcgtg acgcgcttgc ggagcgtgtg
    17641 ggcggcgggg ttgccgcagc ggccgcacac gagggtcagt atcgccagct ggtagaggta
    17701 ccccttggtg ccgaaaatga tcacgctgtg tttccttccg ggtgagtttc cgtccggccg
    17761 gatgccgtcc gttcggatac cgtccgttcg gatggtcgga cgatccgatc ggcggaccgg
    17821 cgccggtcgc accgcacagt ctgacccatc gccgggccga cggggtgagc gccaggcggg
    17881 tccatgccct gggccacgcg ggcgaccccc cggccatgac tgcgaccgcc gccgcgggac
    17941 cggcgtgatg gtcgtctggc cgccgcacgg cggcgttccc ggcttccccg caaggaaggg
    18001 tcccatgccc cgagtccccc gctcggcggg tatcaccgcc gcagccctcg ccctggccct
    18061 gttcgcctcg gcccctgccg tgggagatgc tccggtcgtc tccgatccga gcgtcctcgc
    18121 ccacttcgac ctcgccaagg gggagagccc cgagaacatc gcgctcgcct ccgacggttc
    18181 cgcctacctg acgctgtcct ccgcccggca ggtggtcagg atcgaccgca cgggccgcaa
    18241 gcgggtcctc gcgacgctgc ccgccgtcgc cgacccgcac accccgatcg tcggcgcggc
    18301 cgtcgtcctc ggcatcgcgc gcgcccgcaa cggcaccctg ttcgtcaact acgccaccgg
    18361 taccggcgcc accggcatct ggcgggtgcc cgcccgcggc ggcacggccc ggcagatcgc
    18421 gcagctgccg gcggacggct tccccaacgg cctggccctc gacgagcgca gaggcgtgct
    18481 ctacgccgcc gactcggtgc ggggcgtcgt ctggcgcgtc ccgcggaccg gtggcaggcc
    18541 gacggcctgg gcggccggag ccgcgctgga ggcccgcaac ccgcgacccg cggcccgcgt
    18601 cggagtcaac ggactccggt tccaccgcgg tgccgtgtgg gtgtccaaca ccaacgcggg
    18661 gacgctgctg cgcatccgcg tgcggaacaa cggttcggcc gcggcgatcg agacccgggc
    18721 gaccaagctg tacgccatcg acgacttcgc gttcgtcgag cgccaccgcg acaccgccct
    18781 cgccgcactg accggcggca gcgaggtcgt gctggtccgc ccggacggca cccgtcaggt
    18841 ggtcctcgcc cgcaaggacg ggctgtccaa cccgaccgcc gtggccgtgc gcggccggac
    18901 cgcgtacgta ccgagcgcgg cctacttcac ccagcaggac ccgaacctgc tggtggcgcg
    18961 cgtggaccag cgcgaccgcg gctagccgca cagcggcaca gccgcacagc cgtccggccc
    19021 cgtacccgca ccggggtacg gggccggacg gcgtcggggg ccggacttcg gagggccgga
    19081 gttctgggcg gcgggccgac gacgtcaggc cgccgggcgg accaggccgt actcgtaggc
    19141 gaaggcgacc gcctggaccc gggcccgggc gccgatcttg gccaggatgt ggctgacgtg
    19201 ggacttcacg gtggtggggg cgatggacag ccgggtggcg atctccgcgt tggaccaccc
    19261 ggaggccacc gcgacgagga cgtcgcgctc gcgctcggtg aaggcggcgc gtccgggtgc
    19321 ccgcccgccg ggtcgccggg ggtgctcgtg gcggacggtc tcgatgagcg cacgcgtcag
    19381 tccgggcgtg atgacggcgt ccccggcggc cacgacccgc acggccgcgg tcagttcacg
    19441 gggcgtcgcg tcctggagga ggaatccgcc cgctcccgcg cgcagcgcgg cgtaggcatg
    19501 gccctcgtgg ccggtggagg ccagcaccag gatccgcggg ggtcgcccgg ccggaccctc
    19561 ggggccgggt ggcggggcgg gccgcgcggg gtgtgccggg gccgcggggt gggcgatgcg
    19621 ccggatggtc ccgaggtcgt ccgtaccggg gccgacgccg cccagcagga cgacgtccgg
    19681 ccgcagcgcg gcgctcagcg cgacggcttc ggccccgctc gccgtgtcgc ccacgacggt
    19741 cagatcgggc tcggcggcca ggagcatgcg caggccgacg cgttggaggg actggtcgtt
    19801 cacgatgagt acggaggcca tggcttcgtt ctccatgcgg tgggggagta cgcctcacat
    19861 gaacgaaacg gtttcgttca gttgcttgtc agcgtagccc tccgggcatc gaaacggaag
    19921 cgtttccttg tggctcgggt cacaccccgg ggcgcgccgt cacggacgca caggggtgcg
    19981 cccgggggtg cactcggggg tgccccggga gggccggtcg ccgtctcccg gggtgtccct
    20041 tcgctacgcc cagcagccgt tcacggtcgc cgccaggccg tccatggcgt ccttgatgtc
    20101 gctcgggttg gccgtggagt cgttctcgat gaaggcgaac accttccacc tgccgtcctt
    20161 gccctgggtc agaccgctca gcgcgatggc cccggtgagg gtgccggtct tcgcgtgcac
    20221 cttgccgacc gcgcaccggg agttcacgtc gtcgaagcgg ccccactccg gaccgagcgt
    20281 gctgccggcc tccccggaga cgggcagccc gtccaggatg gagcccaggg tggcggagtt
    20341 gcggggctgc gtcagcagtt ccaggatctc cgcgagcgtg gcggccggga tgcggttggc
    20401 ccgcgacagg ccgctgccgt cgtggatcac gaagttgtcg agcgggacgc cgtaccgggt
    20461 gctcagtacc tggcgcacga cgtccgtgcc gccctcgaag gtggccgggc ggcccgcggc
    20521 gagggcggtc gtccgcagca gggtctcggc gatgttgttg tcgctgacct tgatcatcgt
    20581 gtggacgatg tccgacagtg gtgccgacag gtgccgggcc acggggaagg cgccggggtc
    20641 cgcttgcgcg cgggtcacgg cgccgtcgac ggtgaccccg gccgcggcca gctgccgggc
    20701 gaaggcctgt ccggcgtcga tcgaggtgtc ctggacgccg tggccgtcga cgacgagggc
    20761 gcgcaccgga gcgacggagt ccgggtagta gccggtgttc cagccctccg ccagggccgg
    20821 ttcgccgaag aggctgtcgt ccaccgcgac cttcaccgtc gtcagccccg cggccttgag
    20881 cccggcgacc gcggtcctcg ccagttcggc gaggtcggcg ccggtcaggg tgcggtcgcc
    20941 gccgcccacc agggtgaggg tgccgttccc gtacacgacc cgggtggtga acctgtggtc
    21001 cgggccgagc accgtcaggg cggcggtcgc cgtggcgagc ttggtgttgg acgccggcat
    21061 cagcgcggtc gccccgtcgt ggtcccacag ggtggtgtcg gaatccgggt cgaggacgac
    21121 cccgccgacc ttggagccca gccgggcgtc gacgacccgg gcctcgaggt tggcgaccat
    21181 ctgccggtcg tccgcgccga gcgtccggcc cgccgtgggg ttcccggccg tcgtgccggt
    21241 ggggttgccg gcggcgaacg ccgaggggcc ggccagtgcg gccgacgtga cgggcagggc
    21301 cagcgcgagc acgagcgccc gccgcagagc ggtaccgccg ggcccggtcc cgcggtgccg
    21361 gcgccgaccg cccgggacga ggggacgctc gggcaaggac gccgtcatat cggtcatgag
    21421 gtatctcagg actttcgtgt ggggggtgcg cgaaagaatt cgggcgcacc ttatcacccg
    21481 tcatatttgt cccgggcggg cgaggccggg aattgacggg agttcaacag ccgtcaattc
    21541 cgggcctttt caccgcgaat tcagagtccc gaccccaggc tctgcgtcgt gtaggcgcac
    21601 tccgtgtaga tgtagcccga ctggagcttg gccgtgtccg aggcgggcgt ggccaggctg
    21661 tcgcccttgg gcttgtgcag gaagtacgtc gtcccgaccg gcaggctgat cgtgcgctcc
    21721 ggatagttct tgccgctcgg gcacggcttg aaggacgggt tcagggtgct gccgagcgag
    21781 tacgccttgc agctgccgca ggccttgagg gtgaaactgc cggtgaccgg acccgtgtac
    21841 agcaccgtca cctcgtcggg gctgtcgttc tgcacggtga cggagatgct gccgccggta
    21901 cgcgtcgtcg gcagcttctt cccggcggcc ggcacggtct gcgcgacctc cgccgctatc
    21961 gcgatcttct tcgccagcgc cgcgttcttg gcggtcttgt gcgcggaggc gtagtcggtc
    22021 atggtcttct gcgccgaatc gaagtcgccg tcccggtact ggtccacgcc gcaggtgtac
    22081 gcgccggtgt cggcgctcgc cgcggcccgc agggcgtctc tgtcgagagc cgcgcccgcg
    22141 tccgactgcc cggcgtccag gccgtcgatc tgcgtgccga gcgtggtgag ccgctgcacc
    22201 gcggagcagg gctcggcccc gccgaggtcc ttctccgtgc gcacgacggc cgccgcgacg
    22261 gccggttcga ccttggcggc ctgctccgac cgcgggaacg tggacagcag ctccccgtac
    22321 tgcgaggccc aggtggcctc cccggccgtc agcgccgtcg aggcgcactc gtacagcgag
    22381 gtcgcgagcc ggtcgtccgg ccaggtccgc agcgcgccga gatccgtccc cggcaggctt
    22441 ttggggaccg tgcgcaggta cttcagcggt tccaccgcct cgcagtactt gccctgcgcg
    22501 tacggggcgc cgaccgtcgt gtagaaggcc ttcatccgcg cgggcacctg ttccgcggcg
    22561 cgggagccgg ggtggtccga cctgaggtcc gcgtaggcgt ccagcgcctt gcggtagtcg
    22621 gcccgggccg aggtgaacgc gcggtccccg gccgcgcgca ccagccggtc ggcctcgtcg
    22681 agccggtcga ggagcatctg ctgggtcgcc tcgtcacgcg cgtcgtcgta cagcacgacg
    22741 cccccggccg gtccgacgag caggagcagt cccagcccga gtgcgagcgg cgcgttccgc
    22801 agtcccgcca gcggggtgcg caggccgacg tacgcgccgt gcgccgccac cgcggcgagg
    22861 aacgcgacgt agaggacgag cgcgacgccc ggcacgccgt ccgggtcggc cggcagcgcc
    22921 acgaacagca gcacggcggt ggcggcccag cacagcacca tcagcaccca gcggcgcacc
    22981 agtgcgtagc ccaggccgag accgctgagg ttgagcacgg ccaccgcgac ggcccgcaca
    23041 ccgtccgccg gagcgggcgg cggggacggc ggcgccgacg gcatgggtgg tgcgtacggg
    23101 aaggcgtgat ggttcgtgtc accgaatctg ccgtactggt cccccgacat ggcggctccc
    23161 cccggtcaac tgcgtccgca cgtctacgat ttgtcagtgt acgggcgaac gggaccggcc
    23221 gacaggggcg aaggggttcc tgcatacgat ctgtgacctg ggccgatccg cgcggcgggc
    23281 acaggacgca cacgaaacgg ccgggccgcc acgcgggggc atgcgtggcg gccgcggctg
    23341 cgctatcgcg tcaggcatgg gtcaggccac accccccacc gtcttcttgc ggcgcagggc
    23401 gtagaggccg gtgccggcga cggcgaggat gccgagtc
//
