LOCUS       NZ_BMSI01000021        26303 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence21, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000021
VERSION     NZ_BMSI01000021.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 139887)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 46173
            Orig. end                         :: 72476
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000021.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26303
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26303
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26303
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16303](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16303
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(319..753)
                     /locus_tag="IE189_RS35955"
                     /old_locus_tag="GCM10010496_73130"
     CDS             complement(319..753)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040404.3"
                     /locus_tag="IE189_RS35955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73130"
                     /product="hypothetical protein"
                     /protein_id="WP_189927976.1"
                     /transl_table=11
                     /translation="MGEVEGLGEGMRIRIETTADEGQGALSDLYKWLRLDADVRRQATM
                     EMVPCGKPGVTMGTVEVIDMFLSQGFSALNLAMSYAAWRAARPAAPPITITVTATGQPL
                     TVDDASQETIRRIVEALQAASAADQAERQVEAGDEAGTSP"
     gene            complement(858..1400)
                     /locus_tag="IE189_RS35960"
                     /old_locus_tag="GCM10010496_73140"
     CDS             complement(858..1400)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543776.1"
                     /locus_tag="IE189_RS35960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73140"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_189927977.1"
                     /transl_table=11
                     /translation="MTSAASTIALRAFTELDSVRGDVVDVYAEVRAPLLHMPNYAVTAF
                     GERLDRHGAEPGFTLVLAYADEFPVGYAYGNRIEHGDRYWQRTTPEPTDEYTQHPTVAL
                     KEIGVRDAWRGTGTARRMHDAFLATRDEPYATLMVNPAAGDGKVHKLYQSWGYHDLGQS
                     QPSPASPVLTVMIRPAH"
     gene            complement(1397..2680)
                     /locus_tag="IE189_RS35965"
                     /old_locus_tag="GCM10010496_73150"
     CDS             complement(1397..2680)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337831.1"
                     /locus_tag="IE189_RS35965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73150"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_189927978.1"
                     /transl_table=11
                     /translation="MNATRNTALEAWMREHGYSSNSLADAVNKALEQLTGRTGGLDGSS
                     VRDWKAGRVRWPKAATRRALEAVTGMPPTVLGFVPRGRAPSTPVAPQEDLDMKRRNLIG
                     GFAVAATAAAAPGTTGPRRIGMSDVGRLQQRFAEVIASDHRYGGQLGIEQRAAALADEA
                     LNLQNAGSATQRVRSSLYGCAASFRSSAMWAAIDGRRYGDAKAHMREAQALAEMSGDQA
                     IKFRIWSHAGAMYRHVGRPGEAFAANDVARNLHITRRDPTFASLGLARQAAIHGAAQDR
                     MGTHRALDQAQDALQRVDPHGFRPVWLLAFYDQAELDSLALSAFLTLGDYPTAEFHAHR
                     CLAALRPHMRRSHAITTTRLAHAQLAQGDFEAAAGTAMKVPTDAATQHPRVSRMLQEFG
                     AALRARAPRSSAAQSWTEHTRHVWKATT"
     misc_feature    complement(2453..2455)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3015..3416
                     /locus_tag="IE189_RS35970"
                     /old_locus_tag="GCM10010496_73160"
     CDS             3015..3416
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="IE189_RS35970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73160"
                     /product="ATP-binding protein"
                     /protein_id="WP_229901584.1"
                     /transl_table=11
                     /translation="MRRIAAAKLRLCGLDTVIDEVMVIVSELLTNAVLHSGTRQVALSL
                     RIERGVLLIVVTDGMPGHARRKAVGEDSESGRGLALVEALARENGGSWGTGNAGAETWC
                     RLVLPRRLPDQPACSSARCPLPLVPLPDC"
     misc_feature    3402..3404
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3476..4909
                     /locus_tag="IE189_RS35975"
                     /old_locus_tag="GCM10010496_73170"
     CDS             3476..4909
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="IE189_RS35975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73170"
                     /product="ATP-binding protein"
                     /protein_id="WP_189927980.1"
                     /transl_table=11
                     /translation="MDRFIFGKVGSVLVTPLLCAAVFQSVVVLRLGPAKLVVAVAGSVL
                     VAALVGFLRARTVTAVLQRQREAEFQRITEAVSAAETTMIWTAEQLCQGKRPPLPEEPV
                     PGGRGAVDRVVCLIGSLQVQGAGALLRVHDESPAAVLVEMHRILARRQHGLIGELLEQV
                     TGLQKGTEDPVLLDRFFSIDHLATRLRRMVESVSVVLGGRSLRETRAPVPVSVVLRGAK
                     SEVVRYRRVQTVAGGVGTAFSLPAHVHPDVAHLLAELIDNGLEHSDPVTLVVVRAQKVA
                     AGLLIEVEDRATLLMDPAKRDLLNRLIARPEQADVAAHVRNGNLGLITTARIAARHGLK
                     VWLIQNPMGGTTANVVIPERYLVPTAPLIGTVTVTAGPGAAAGAQPDAGVAQPAYAGAV
                     QPPVRPAPGGVDPLPRRQRVERPMPAAGGGPAVPSRAANPGAVADWRSGLHAGLNASPT
                     PGARPGSGPGPGAGPISPS"
     misc_feature    3566..3568
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4940..5452
                     /locus_tag="IE189_RS35980"
                     /old_locus_tag="GCM10010496_73180"
     CDS             4940..5452
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015232.4"
                     /locus_tag="IE189_RS35980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73180"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_189927981.1"
                     /transl_table=11
                     /translation="MTYDVPDTTTAAPCELPAASPEEVKGQMARLLEQFVQDTHGVTDA
                     MLGSRDGIKQVWCSHMDADWVDELAAAFSGMTALARGIKGPMGAQLPPQQVLVERDDAL
                     FLLTDAGVGKAFNKSGATVATVLGVLARSDANIGAVAFDIGRLVARFAPFMTTPVRARD
                     GQDGGAE"
     gene            5491..5862
                     /locus_tag="IE189_RS35985"
                     /old_locus_tag="GCM10010496_73190"
     CDS             5491..5862
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491176.1"
                     /locus_tag="IE189_RS35985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73190"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_229901574.1"
                     /transl_table=11
                     /translation="MDDRASIVRLYAITDGRTRPRHALSLHTVLGPGRRRPHPGVGEES
                     TQIINLCRQRRRPLAELAGTTGLHVAAVRVLVSDLIDAGSLTVPVPDMPDGADPSLQML
                     FAVSAGLRRKYPNAAAKAG"
     gene            5868..6470
                     /locus_tag="IE189_RS35990"
                     /old_locus_tag="GCM10010496_73200"
     CDS             5868..6470
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018386208.1"
                     /locus_tag="IE189_RS35990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73200"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_189927983.1"
                     /transl_table=11
                     /translation="MTPPPLEPGERAVVKLVVAGGFGVGKTTAIAAISDIPPLRTEALL
                     TAHSQSVDSLEGVEDKTTTTVAFDFGRVGWDEPQPVELYLFGTPGQPRFWSLWHDLAQG
                     ALGAVVLADTRRLDSSFPAADFFEQLRLPFVIAINQFPHTAARSLAEIREAFDVSDLVP
                     LMFCDARHADSVAAVLLTLVQHVVTTTAAPDTTLLDA"
     gene            6470..7090
                     /locus_tag="IE189_RS35995"
                     /old_locus_tag="GCM10010496_73210"
     CDS             6470..7090
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325325.1"
                     /locus_tag="IE189_RS35995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73210"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_229901575.1"
                     /transl_table=11
                     /translation="MPLTPTPQPTPAPATPPPAALPPVERRIELFTDVPATELHEMATR
                     LSRLNELGIPLKATEALDHLTDDLAERTGFLYAMVNAFADEQTFLGLHNPPPDAGYPLV
                     GRTMSRSDGYCPEVIQGKLGLPLFDVAASPRFQSNPVVDAIGIQSYFGVPVIDAATDLA
                     LLTVCVVDPEPRSLADAARLLRLVHAAGRQAADILQIITTPAP"
     misc_feature    6530..6532
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7126..8391
                     /locus_tag="IE189_RS36000"
                     /old_locus_tag="GCM10010496_73220"
     CDS             7126..8391
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010349977.1"
                     /locus_tag="IE189_RS36000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73220"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_189927984.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.3e-18, bitscore:
                     59.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.3e-18, bitscore:
                     58.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6.3e-37, bitscore:
                     119.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIPAPPATLDRFLTPAHHALWEDADDFAAAEVLPLVDRMESQPS
                     RVDRTTARLLAGRRWFGVTVPTAFGGMHAGHVAKTILIHRLARVSGAAAAILQAGLIPV
                     AALLHYGTPDQHTALLPAVADGSLLMSIAVTEPDQGGHIGAMTTSAEWDGTAWLLSGIK
                     VHVGNSHLAHQHIVVARTAPPGTRTSKALTAFLVAADQKGVHVHRYTSRLGLHGFSFGT
                     ITFDRVRIPPHHILGEVGQGFDVAQSSSILYGRPNLAAVSLGLHEAALTLTTQYVSSRP
                     RHGKTVADLAVIRNRLGQMNARLLMAQILAYHAADMLDHGLPCDAELCAAKGLGHELAA
                     ETGRDAMELHGANALTEGRPLERVWRDMQTTYAPAGTGEVQRIRLAQALLHEHGHPDHH
                     TPHTQWSARHAHHPRADPATTP"
     gene            8625..9290
                     /locus_tag="IE189_RS36005"
                     /old_locus_tag="GCM10010496_73230"
     CDS             8625..9290
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004933668.1"
                     /locus_tag="IE189_RS36005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73230"
                     /product="hypothetical protein"
                     /protein_id="WP_189927985.1"
                     /transl_table=11
                     /translation="MTTSADPGGLVPFITHREGEDAAPDNLILLPHSDGRLHLHYLDED
                     PRDRDIHGVLWARCSFNPIDPHGQPTGRPLFKLMHPYRQLMTMQMLHCQVCTAPARTPL
                     GLIFLAGPHDHTGAPQVLTNQPPVCARHVRTAARLCPHLDGTPTVYLAQSAPLYGATGT
                     LYGLGTHGTQPIAQPGPPLPYSHPDMSCFLASQQIRRLASFRSVGLEELLEALRPESA"
     gene            9572..9748
                     /locus_tag="IE189_RS36010"
                     /old_locus_tag="GCM10010496_73240"
     CDS             9572..9748
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825826.1"
                     /locus_tag="IE189_RS36010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73240"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_189927986.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.9e-14, bitscore:
                     45.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRNVTHGTTQIQEPAVPEPDGFDLNVSLLEVADAAGLTNLTDDG
                     CGSTCGACTTNVA"
     gene            10001..12940
                     /locus_tag="IE189_RS36015"
                     /old_locus_tag="GCM10010496_73260"
     CDS             10001..12940
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543779.1"
                     /locus_tag="IE189_RS36015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73260"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_229901576.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.3e-195,
                     bitscore: 643.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.5e-17,
                     bitscore: 57.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.1e-24, bitscore:
                     78.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSVWGDAALTEAVRHASPVLAAQCEALCRSAAPDGRDVRRVGLS
                     LARYLLRAGHRPTPFGLFAGVVTAAFGTATTAVWGEAHVPVARASAEWLSLLVEQLEKS
                     GELLPLLSVVVSNTSFERDGHLIVPYQEDGLAGQLRAVEASIELTAPVRIVLSAAGSPI
                     RVEELAGKLTAEFPSVVPERACGLLAGLIRRRVLVTNLHAPATEADALGHVLAQLDAVE
                     AGSLGLLEGTVQELRAIQTGLQTCDGANARESVTIRMRKLVPGLRRHPLALDLRLDAHL
                     TLPDQVAREAERAATVLTQLSARPYGSRAWADYHQRFYERYGIGTMVPLQEVLADSGIG
                     YPDGYPGAPASGRRRVSARDDVLVRLAQAAALDGHDEVVLTDELVDALDRGSGQQRVPP
                     HLEIGIRLHAASMKEAQRGQFTLEVTSVSRGAGVTTGRFASVLGRGPREALCAELAELP
                     TADTGTDPAQLSFPPLLSDTAHVARAPRVLPLLISLDEHREACADVLTPADLAVACDGR
                     RMYLAAPALGRRIEAAGMHALNLTEHTPPMARFLIEIARAQCAQVTVFDWGAAAAMPYL
                     PRLRYGRIVLAPARWRMDACDLPGRDHPGAEWDIALAAWRERRRLPRHVRLTENDRLLP
                     LDLDQASCRSLLRQHLDRAPSAVLTEAAPAQAYGWSAGRAHDIVVPLKTTRPPVWPALP
                     RPSTARTLSHTQIQPPASSSVLLAALYADLRCQDAVLTRHIPRLIRRLGSPPWWFIRFR
                     DPHQHLRLRIALAHPDDFADTAHTVSVWADELRGAGLLADLRYPTSYREMGRWGSGPAW
                     DAAEDVFQADSRAVVAELAQPRRPPQRTLVAAHTFAICSAFLGSPEAGARWLIDHVPHR
                     LTGPVPRQQFTQAVHMSNPRNDWAALRATAAGEAIVTAWADRDTALAAYRLHLPGAHTE
                     GIALDDVLTSLLHTHFVRHVAVNFPEEEICLHLARAAALAFTASAGSQP"
     misc_feature    10301..10303
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10337..10612
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE189_RS36015_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.80E-18"
                     /identifier="RREFam001.1"
                     /label="IE189_RS36015"
                     /locus_tag="IE189_RS36015"
                     /protein_end="204"
                     /protein_start="112"
                     /score="57.0"
                     /tool="antismash"
                     /translation="VVVSNTSFERDGHLIVPYQEDGLAGQLRAVEASIELTAPVRIVLS
                     AAGSPIRVEELAGKLTAEFPSVVPERACGLLAGLIRRRVLVTNLHAP"
     gene            12937..14205
                     /locus_tag="IE189_RS36020"
                     /old_locus_tag="GCM10010496_73270"
     CDS             12937..14205
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143557.1"
                     /locus_tag="IE189_RS36020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73270"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_189927987.1"
                     /sec_met_domain="LANC_like (E-value: 4.6e-40, bitscore:
                     130.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEPPAITLAAAIADRLSHPDTAPCAATTDEARQHLAHGPIGIAL
                     LHIELAAAGLGPWQRAHNWLAAATRRPFTTGADSHPFYGAPALAHVLACAAEHLPGAYR
                     RDLDRLDRHVAGDVKRRLDAAHRRIDAGRLPVLAEFDAIRGLTGYGRYLLHRDADAPAL
                     RALLEYCVRLVEPIPHHDEALAGWWTLTGPSGRIDISFPGGHGNNGMAHGVGSVLALLA
                     LGARRAVTVAGHHEAMRTILAWLDHWKTITASGPVWPYWITRADQRAGLLKPSTPQRPS
                     WCYGTAGLARAQQLAAHALSDTARRAQAEAALLDALTDPAQLRATVDAGLCHGVAGLAH
                     LASRTAADACPDIAAELRAVLPGLLATLIPPGAAPHEATAALVNGRAGPGLLDGAAGIA
                     LAVLSAAGAQPPRTGWDACLLIA"
     gene            14222..16303
                     /gene="fxlM"
                     /locus_tag="IE189_RS36025"
                     /old_locus_tag="GCM10010496_73280"
     CDS             14222..16303
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543781.1"
                     /locus_tag="IE189_RS36025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73280"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_189927988.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-26, bitscore:
                     86.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 2.5e-44, bitscore: 144.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDRWQQHNITFTDRQTARQAAADRIAPVLLEAEGQQLTGWWFM
                     NKQPWPLRYLADRPAPDVTEVLDSLVRDNIAQSWTSSIYEPETEAFGGAAAMTAAHALF
                     HEDSRHLLHYQPGPRTLGRRETAVLLMSSLMRAANLDWFEQGDAWAKAAALRPHPGRPV
                     SERSVAWPAAMQRLMSAEARSLCRQGGPLNGHAEWIAAFERTGTTLAYLAVQGELTRGV
                     RAVIAHHVIFHANRAGLPTADQHTLFHIAREAVMRSSDNIASTAATGSQADSVGAVNTV
                     TLTTSEADEATRLRHALVDKIQADGHARTPAVETALRTVPRHLFVPQAPLSEAYANAPV
                     NIKYDTDGTSISCASQPDVVALMLDQLQAQPGERILELGAGTGYNAALIGHIVGPDGHV
                     TTLDVDDDLVEGARAHLAATGFTHVEALARDGALGHTEGAPYDRIIATVGAHGIPHAWL
                     EQLAPGGRLVTPQRLKGSVSRSIVYEERDGRWVSSGSQMNTFMPLRRGIADDDRRVVPL
                     TADGTVRLQAPAGQQIDADALTGILHQPRTEEWTGMTVRAMESPEWMELFVSCSLPSGL
                     IRMLFPATAKGTVLTQDPYPSSTAAVDKDAVTYLARRQSEKKTPEGGKLWEFGVIGHGP
                     GSEELAAKVADAIRTWDRAYRGREATFEILPLDGPVIEQQPGVFLLDTPLNRVLVTWQ"
     gene            16382..17533
                     /locus_tag="IE189_RS36030"
                     /old_locus_tag="GCM10010496_73290"
     CDS             16382..17533
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999997.1"
                     /locus_tag="IE189_RS36030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73290"
                     /product="hypothetical protein"
                     /protein_id="WP_189927989.1"
                     /transl_table=11
                     /translation="MDPRGPIAQRFPLISRFRPACLPLPRRVHALVELSDTAVAKADPG
                     LASSVYNQAALLASDIGLPHLARTWCHQHAAAYLHAAPLPAMSAIRALEPVVNLARLQI
                     RAGNTEDGRHRLLTLYKAISDGTDAQFEDIHIPAELTTSDTDRHEVRAWLWRVVLADGT
                     RTLTTAGRFDEALTHIETHHGIGQRMLDGRQVAVIAALGHDPAGAADIVAQTAPGEPWE
                     NAVTSCLAVMCNQLALHPAGPPLSELVNTYIQRQPHPGTTVFDTRLGLTILDLHDQPNS
                     SAAHRIAKELHRRSIIATDGYAARECLANSRFTELVSTQETRASRELTRSCALGSGHLP
                     APHPTQLLRALRFSDEVIRAAAAELRAARPSSRARGAGRRSYP"
     gene            17630..17881
                     /locus_tag="IE189_RS36035"
                     /old_locus_tag="GCM10010496_73300"
     CDS             17630..17881
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE189_RS36035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010496_73300"
                     /product="hypothetical protein"
                     /protein_id="WP_189927990.1"
                     /transl_table=11
                     /translation="MPDLAVILTAEPDRIAERGITHRWRLNPTDPPREVDLYRETAAYL
                     TSKGVRVLLLDNSAYTPSDVARRIADLIPPLPLLNLKA"
     misc_feature    17870..17872
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17904..18356)
                     /locus_tag="IE189_RS36040"
                     /old_locus_tag="GCM10010496_73310"
     CDS             complement(17904..18356)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040274.3"
                     /locus_tag="IE189_RS36040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73310"
                     /product="DUF5959 family protein"
                     /protein_id="WP_189927991.1"
                     /transl_table=11
                     /translation="MDLIHLADPDGNRCIVRVTGRFQPGVLTGHDILHADVLVSASFVD
                     ARLDLYLFQHDLDSWEQELSNLGPGQTVSIGGDRGLILDIHVHEDGWLSIQVSDPDRLT
                     TALGTRPQEDWIDEHRGRLQQVRLTWPREVIETAPGAYEWSPNRKR"
     gene            complement(18441..19061)
                     /locus_tag="IE189_RS36045"
                     /old_locus_tag="GCM10010496_73320"
     CDS             complement(18441..19061)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1238: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020556918.1"
                     /locus_tag="IE189_RS36045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73320"
                     /product="transposase"
                     /protein_id="WP_189927992.1"
                     /transl_table=11
                     /translation="MAAGKSIAAERGAWIVFEDEAGQSMTAPRARTWGRRGCTPVVWVR
                     GRGSGRVSMVGMTCYKPGEWSRLFYAVREYGGRKGQPKGFGWCDFRDLIVRGHIQLGSP
                     IVLIWDNVRLHLPKPLREFIDANAEWLTVVQLPTYAPDLNPTEGVWSLVKRDIGNLAAA
                     SLGQVIRAVKRRLKKLQYRPDVIDGYLAGTGWAPGHVTLQGRA"
     gene            complement(18986..19441)
                     /locus_tag="IE189_RS36050"
                     /old_locus_tag="GCM10010496_73330"
     CDS             complement(18986..19441)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024980.4"
                     /locus_tag="IE189_RS36050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_73330"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_189927993.1"
                     /transl_table=11
                     /translation="MTAEAGWALDSAARDSRDEAAFLRRQWREREKAGVLSEGSPGWPR
                     LSDTQIVRLERELERGPLIHGWADQWWTLDRIKTLIGCLFHVSYTVEGTWLLLKRHGWS
                     WQQPARRAIERDDTSVEVWKKETWPRVRASRRSGGPGSSSRMRPGSR"
     gene            <19379..19594
                     /locus_tag="IE189_RS36055"
                     /pseudo=""
     CDS             <19379..19594
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558177.1"
                     /locus_tag="IE189_RS36055"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RGLVPRIARRGVESPARLGRHRWVIERTMSWLSGCRRLHRRYERK
                     HEHFIGFTEIAVMLICLRRLGVSAGR"
     gene            19605..20144
                     /locus_tag="IE189_RS36060"
                     /old_locus_tag="GCM10010496_73340"
     CDS             19605..20144
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE189_RS36060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010496_73340"
                     /product="hypothetical protein"
                     /protein_id="WP_189927994.1"
                     /transl_table=11
                     /translation="MTDDAVIWNRLAALLPEAEAQDVKDCWDIGEQEAGLGLLVSGILG
                     HQMPISETDRAQISVLAETWGEREALTPQILQFRDEDEPGPLKLIEGDGSTVPEAIGGA
                     AQDLAGLVLVPWIACTRCGQVLMRAHSRESWGDLSYLARHYVITTPNRATVSLLFSADS
                     AGEAFVSLQRQCSDAP"
     misc_feature    20157..20170
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.51"
                     /tool="antismash"
     gene            20197..21014
                     /locus_tag="IE189_RS36065"
     CDS             join(20197..20545,20545..21014)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009332786.1"
                     /locus_tag="IE189_RS36065"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5 family transposase"
                     /protein_id="WP_189927995.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MGRGTWSWIVPDGLWEIAKPLIPPSKVRPQGGGTQDTPDETLFAA
                     IVYVLVSGCAWRALPPCFGISKSTAHRRFLIWSRAGVWGRLHEAVLHRLDDADLVDVTR
                     VVLGTAHVRAKKGGEHTGPSPVDRGKPGSKMHVLSDANGLPLAVSLSAANVHDSEGLKP
                     MVAGHQTKHDPFRGRHFKPQRLHADKAYDIPHLRKWLRGKRIGVRIARKGIESGERLGR
                     RRWVIERTMSWLSGYRRLSPRYERNPRNYLAFLGLAAALCCYKRLVRLTT"
     gene            complement(21169..21783)
                     /locus_tag="IE189_RS36070"
                     /old_locus_tag="GCM10010496_73370"
     CDS             complement(21169..21783)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE189_RS36070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010496_73370"
                     /product="hypothetical protein"
                     /protein_id="WP_189927996.1"
                     /transl_table=11
                     /translation="MHDLLRRLRGSLALLHEEGERGDVVDWRAAAAELQVESFPEDYME
                     FVSAFGAGTIEESLFISIPRPGTTGEPLSLTRLPGHARRSASMNTWQEVDEGLRNRLED
                     MLVWGQTNSADMLCWVTSGADPDQWPLAVWERHGGGWKIHKCGMVEFLLKLLSGEFSEC
                     PVSDETLWGIQSARFLNFRDEERIIDTGIDPWTGRTVNRFD"
     misc_feature    21908..21922
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.46"
                     /tool="antismash"
ORIGIN
        1 gctgagcgtg tgcgttcgac agagccagat agagctcacc gttcggggag accagtccgt
       61 gccccgcgaa gtagaccacc agcgcttctt ccgcctcggc tgcggcatcg tgcacggcat
      121 ccaggaccgc gtccggggac gtcgggttca ggagaacagt gcactgatcg ggacgccgta
      181 gcccccacag atcggggtcg cccaaaacct tcgccaggcg gttgacattg ttccccaccg
      241 acggcaggtc aggcagcgtg tcgtacctgt ccacccccac gatcacggca cgagatttcg
      301 ccgggtcggg cagtcgcttc acgggctggt gcccgcttcg tcaccggcct ccacctgtcg
      361 ctctgcctgg tcggcagcgg acgcggcctg gagtgcctcc acgatgcgcc ggatcgtctc
      421 ctgggacgcg tcgtccactg tgaggggctg gcctgtggcc gtgaccgtga tggtgatcgg
      481 tggcgcggcc ggacgcgcgg cgcgccaggc cgcataagac atcgccaggt tcagcgccga
      541 gaacccttgg ctgaggaaca tgtcgatgac ctcgaccgtc cccatggtga cgccgggctt
      601 gccgcacggc accatttcca tcgtggcctg ccgtcgtacg tcggcatcca gcctcagcca
      661 cttgtacagg tcggacaggg ccccttgtcc ttcgtcggca gtcgtctcga tccggatgcg
      721 catgccttcc cccaaccctt ccacctcgcc cacgataggg aaggttgcgc ctcctggggg
      781 ccgaaacgcc gatcgacggg agccccgatc ccgccctctg tggtggggtg gttgaagcag
      841 gttgccgaag gcctgggtca gtgcgcgggg cgaatcatca cagtgaggac cggtgacgcg
      901 ggtgacggct ggctctggcc caggtcgtgg tagccccacg actggtagag cttgtggacc
      961 ttcccgtcac cggccgccgg gttcaccatc aacgtcgcgt atggctcgtc tcgcgtggcg
     1021 aggaaggcat catgcatacg ccgcgcggtc ccggtccccc gccacgcgtc tcgtacgccg
     1081 atctctttca gggccacggt tggatgctgg gtgtattcgt cggtcggttc cggtgtcgtg
     1141 cgctgccagt acctgtcccc gtgttcgatg cgattgccgt aggcgtagcc gacgggaaac
     1201 tcgtccgcgt atgcgaggac gagtgtgaat cctggctcgg caccgtgccg atccagccgc
     1261 tcgccgaatg cagtgaccgc atagttcggc atatggagca gcggggcgcg cacctctgcg
     1321 tagacatcca ccacgtcgcc gcggacggag tcgagttcgg tgaacgctcg gagtgcgatc
     1381 gtggatgctg ccgaggtcat gtggtggcct tccaaacgtg gcgggtgtgc tcggtccagc
     1441 tctgcgcggc ggaactgcgc ggcgcccgtg cacgtagcgc agcaccgaac tcttgcagca
     1501 tgcgggagac acgggggtgc tgggtagccg cgtcggtcgg cactttcatg gccgtgcccg
     1561 cagccgcctc gaagtcgcct tgagcaagtt gggcatgcgc gagacgcgta gtggtgatgg
     1621 cgtgtgaccg gcgcatgtga ggccgcaggg cagccaggca gcggtgggcg tggaactcgg
     1681 cggtcgggta gtccccgagc gtgaggaagg cggagagggc gagggagtcc agttccgcct
     1741 ggtcatagaa ggcaagcaac cacaccggcc gaaagccgtg tgggtccacg cgttgcaaag
     1801 cgtcctgtgc ttggtcaagc gcccgatggg tgcccatccg gtcctgcgcg gctccatgga
     1861 tggctgcctg ccgggccagg ccgagagacg cgaacgtggg atcccgacgc gtgatgtgca
     1921 ggttccgtgc gacgtcgttc gcggcgaagg cctcccctgg acggccgacg tgtcggtaca
     1981 tggcccccgc atggctccag atgcggaact tgatcgcttg atctccggac atctcggcga
     2041 gggcctgggc ctcgcgcatg tgcgccttcg cgtcgccgta gcgacggccg tcgatcgctg
     2101 cccacatggc ggaggaccgg aacgaggcag cgcatccgta caagctgctg cgcacgcgtt
     2161 gggtggcgct gccggcgttc tggaggttca gcgcttcgtc ggcgagtgcg gcggcccgct
     2221 gttcgatgcc aagttgcccg ccgtagcggt ggtcactagc gatgacctcg gcgaagcgct
     2281 gttgaaggcg gccgacgtcg ctcatgccga tgcgacgggg tcctgtggtg ccgggggcag
     2341 cggctgctgt tgcggcaaca gcgaagccgc cgatgaggtt acgacgcttc atatcgaggt
     2401 cctcctgcgg tgcaactggg gtggacggag cccggccccg tggcacgaac cctaagactg
     2461 tggggggcat gccggtgact gcctcaagtg ccctgcgggt agcggcttta ggccaccgga
     2521 cccgtcctgc cttccagtcc cggacggagg agccgtccag tccgccagtc cgtccggtga
     2581 gctgctcaag ggccttgttc accgcgtcag ccaggctgtt ggagctgtag ccgtgctccc
     2641 gcatccacgc ttcaagagcc gtattgcgcg tggcattcat gcgcgcaccg tagcggcttg
     2701 gcgcccacct gtcaggtaaa gcgttgggca aatcggccta ggtcgttctg tcggttcagt
     2761 cctctatcgc cctaaccaag ggacatcgcg agccagttat ctggttgctg gccagccgat
     2821 ccgttaacgg cctccttcgc cacctcgctg agagtgcaga tctgaccacg aaggacgtga
     2881 tgacaacgac tgctgtacga acgcctctcg cggttctgca ccgcgacggg gagttgatga
     2941 gggagcggat cgaagtcctc ccccgcaagg gtgacgatcc gccccgcctt caggacgcga
     3001 cccgcgtagg ggctatgcgc cggatcgcgg cggccaagct caggctctgc ggcctcgaca
     3061 cagtgatcga cgaagtgatg gtcatcgttt cggagctgct gacgaacgca gtcctgcaca
     3121 gcggtacccg tcaggtcgct ctgagtcttc gtatcgaacg cggtgtcctg ctcatcgttg
     3181 tgaccgatgg gatgcctggc cacgcccgcc gcaaggcggt cggggaggat tccgaatcgg
     3241 ggcgcggcct ggctctggtg gaggctttgg cccgggaaaa cggagggagt tggggcaccg
     3301 gcaacgctgg cgcagagacc tggtgccgcc tggttctccc gaggagactg cccgaccagc
     3361 ctgcgtgttc gtctgctcgc tgtccccttc cgttggtgcc cttacctgac tgctgaggat
     3421 ttccatgtcc gtccgtctca ccacccgtcg ttgcgcgcac ggccgtcgtc cccgtgtgga
     3481 tcgcttcata ttcggcaagg tcggcagtgt gctcgtcacg ccgctactgt gcgcggccgt
     3541 cttccagagc gtcgtggtcc tccgattagg ccccgcgaag ttggtcgtcg cggtggccgg
     3601 cagcgtgctc gttgcggcgc tggtcggatt cctgcgcgca cggaccgtta ctgctgttct
     3661 ccagcgtcag cgcgaggcgg agttccagcg gatcacggag gcggtgagcg ctgccgagac
     3721 gacgatgatc tggacggcgg agcagctgtg ccaggggaag cggcctccgc tgcctgagga
     3781 gcctgtgccg ggcgggcggg gtgcggtgga tcgggttgtc tgtctgatcg gcagtctgca
     3841 ggtgcagggg gctggtgctc tgctgcgggt gcatgacgag tcgccagcgg cggtgctggt
     3901 ggagatgcac cggatcctgg cgcggcgcca acacggcctg atcggcgagt tgttggagca
     3961 ggtgacgggg ttgcagaagg ggactgagga tccggtgctt ctggaccggt tcttcagcat
     4021 tgatcatctg gcgacgcggt tgcggcggat ggtggagagc gtgtccgtgg tcttgggcgg
     4081 gcggtctctg cgggagaccc gggcgcctgt tccggtctct gtggtgctgc ggggcgcgaa
     4141 gtccgaggtg gtccgctacc ggcgcgtgca gacggtagcc ggcggcgtcg gaacggcgtt
     4201 ctcgcttccc gctcacgtgc atccggatgt ggcgcatctg ctggctgagc tgatcgacaa
     4261 cgggctggag cattccgacc cggtgacctt ggtggtggtg cgggcgcaga aggtggcggc
     4321 cggcctgctg atcgaggtgg aggaccgggc gacgctcttg atggacccag ccaagcggga
     4381 tctgctgaac cgtctgatcg cgcgcccgga gcaggcggac gtcgcagccc acgtccgcaa
     4441 cgggaacctg gggctgatca cgactgcgag gatcgctgcg cggcatggtc tgaaggtctg
     4501 gctcatccag aacccgatgg gcgggacgac cgccaacgtg gtcatccccg agcgttatct
     4561 cgtgccgacc gctcccctga tcggcaccgt cacggtcacc gccggcccgg gggccgcggc
     4621 cggggcgcag ccggatgcgg gagttgcgca gccggcgtat gcgggagctg ttcagccacc
     4681 tgtccgtccc gcccccggcg gcgtggatcc gctgcctcgc cgtcagcgcg tggagcggcc
     4741 catgccggca gcgggcggcg ggccggcggt gccttcccgg gctgcgaatc ctggggccgt
     4801 ggccgactgg cgtagcggtc tgcacgccgg gctgaacgcc agccctaccc ccggcgcccg
     4861 cccgggttcc ggacccggcc ccggcgcggg cccgatcagt ccttcctgac tctcactgat
     4921 tcgtatggag cgatctgcca tgacctacga cgtgcccgat acgacgaccg ccgcgccctg
     4981 cgagcttcct gcggcttccc cggaggaggt caaagggcag atggcgcgcc tgctcgagca
     5041 gttcgtgcag gacactcatg gcgtcaccga cgccatgctg ggttcgcgcg acgggatcaa
     5101 gcaggtgtgg tgctcccaca tggacgccga ctgggtcgac gaactggccg cagcgttctc
     5161 cgggatgaca gccctggccc ggggcatcaa ggggccgatg ggggcgcagc tgccgcccca
     5221 gcaggtcctg gtggaacgcg acgacgccct gttcctgctg accgacgcag gtgtggggaa
     5281 ggcgttcaac aagagcggtg cgaccgtggc gacggtgctg ggggtgctgg cccgctcgga
     5341 tgcgaacatc ggcgcggtcg cgttcgacat cggacgcctc gtggcgcggt tcgcgccgtt
     5401 catgaccacc ccggtgcggg cgcgcgacgg ccaggacggg ggtgccgagt gacccggccc
     5461 gcgcaccggg gtgcgttacc ggctggggtg gtggacgacc gggccagcat cgtgcggctg
     5521 tatgcgatca cggacgggcg cacccgtccc cgtcatgctc tgagcctgca caccgtgctg
     5581 ggaccgggcc gtcggcggcc ccatcccggc gtcggtgagg aaagcaccca gatcatcaac
     5641 ctgtgccggc agcggcgccg cccgctcgcc gagctcgccg ggaccaccgg tctgcacgtg
     5701 gccgcggtca gggtcctcgt ctccgacctg atcgacgcgg gctccctgac cgtgcccgta
     5761 cccgacatgc cggacggcgc ggatccgagt ctgcagatgc tgttcgcggt cagtgcgggc
     5821 ctgcggcgca agtaccccaa cgcggccgcg aaggccgggt gacccccatg accccacccc
     5881 cgctggagcc gggtgagcgg gcggtcgtca agctcgtcgt cgccggaggg ttcggtgtcg
     5941 gcaagaccac cgccatcgcc gccatcagtg acatccctcc cctgcgcacc gaggccctcc
     6001 tcaccgcaca cagccaaagc gtcgacagcc tcgagggcgt ggaggacaag acgaccacca
     6061 cggtcgcctt cgacttcggc cgcgtcggct gggacgagcc ccagcccgtc gagctctacc
     6121 tgttcggcac cccgggacag ccgcggttct ggagcctgtg gcacgacctg gcccagggcg
     6181 ccctcggcgc cgtcgtcctg gccgacaccc gccgcctcga cagcagcttc cccgccgccg
     6241 acttcttcga acagctccgc ctgcccttcg tcatcgccat caaccagttc ccccacaccg
     6301 ccgcacgcag cctggccgag atccgcgaag ccttcgacgt cagcgatctc gtgccgctga
     6361 tgttctgcga cgcccgccac gccgactccg tcgccgccgt cctgctcacc ctggtccagc
     6421 acgtcgtcac caccaccgcc gcccccgaca ccaccctcct ggacgcctga tgcccctcac
     6481 ccccaccccc cagcccaccc ccgcccccgc cactcccccg cctgcggcct tacccccggt
     6541 ggagcgccgg atcgaactgt tcaccgacgt gccggccacc gaactccacg agatggccac
     6601 ccgcctgtcc cgcctcaacg aactgggcat ccccctcaag gcaaccgaag cactcgacca
     6661 cctcaccgac gacctcgccg aacgcaccgg attcctctac gcgatggtca acgccttcgc
     6721 cgacgaacag accttcctcg gcctgcacaa ccccccaccc gacgccggct accccctcgt
     6781 gggccgcacc atgagccgct ccgacggcta ctgccccgaa gtcatccagg gcaagctcgg
     6841 cctgcccctg ttcgacgtgg ccgcctcccc acgtttccag agcaaccccg tcgtcgacgc
     6901 catcggcatc cagtcctact tcggcgtccc cgtcatcgac gccgccaccg acctcgccct
     6961 gctcaccgtc tgcgtcgtcg atcccgaacc gcgctctctc gccgatgccg cccgcctcct
     7021 gcgcctcgtc cacgcagcag gccgccaagc cgccgacatc ctccagatca tcaccacgcc
     7081 ggccccctga cacaccccca ccccctgccg cgagagggac ccgccatgcc catacccgca
     7141 ccacccgcca ccctcgacag gttcctcacc cccgcccacc acgccctgtg ggaagacgcc
     7201 gacgacttcg ccgcagccga ggtcctcccc ctggtggacc gcatggaaag ccagcccagc
     7261 cgcgtcgacc gcaccaccgc acgcctcctg gccggccgcc gctggttcgg cgtcaccgtc
     7321 cccaccgcct tcggcggcat gcacgccgga cacgtcgcca aaacgatcct gatccaccgc
     7381 ctcgcccgcg tctccggcgc ggccgccgcc atcctccaag ccggcctcat ccccgtcgcc
     7441 gccctcctcc actacggcac ccccgaccag cacaccgcgc tgctgcccgc cgtcgccgac
     7501 ggcagcctgc tcatgtcgat cgcggtcacc gaaccggacc agggcggcca catcggcgcc
     7561 atgaccacca gcgccgaatg ggacggcacc gcctggctgc tgtccgggat caaagtccac
     7621 gtcggcaaca gccacctcgc ccaccagcac atcgtcgtcg cccgcaccgc tccacccggc
     7681 acccgcacct cgaaggccct gaccgccttc ctcgtcgccg cagaccaaaa aggagtccac
     7741 gtccaccgct acaccagccg cctgggcctg cacggcttca gcttcggcac gatcaccttc
     7801 gaccgcgtcc gcatcccccc gcaccacatc ctcggcgagg tgggacaagg cttcgacgtc
     7861 gcccagtcca gcagcatcct ctacggcaga cccaacctcg ccgccgtcag cctcggcctg
     7921 cacgaagcag ccctcaccct caccacccag tacgtcagca gccgcccccg ccacggcaaa
     7981 accgtcgccg acctcgcagt gatccgtaac cggctcggac agatgaacgc ccgcctgctc
     8041 atggcccaga tcctcgccta ccacgccgcc gacatgctcg accacggcct gccctgcgac
     8101 gccgaactct gcgcagccaa aggcctcggc cacgaactcg ccgccgaaac cggccgcgac
     8161 gccatggaac tgcacggcgc aaacgccctc accgaaggcc gccctctcga gcgggtctgg
     8221 cgcgacatgc agaccaccta cgcccccgcc ggcaccggcg aagtccaacg catccgcctc
     8281 gcccaagccc tcctccacga acacggacac cccgaccacc acaccccaca cacgcagtgg
     8341 tccgcccgcc acgcccacca cccccgagca gaccccgcaa ccaccccata gacccccgcg
     8401 cacggcaccc cccgtgcatc cgcagtgccg tgcgcgggcc cccaccccgc tgccgggccc
     8461 acaccccacc cgtcccggcc cggcagcggg gcccccggac cacgacacgg cccgcggcgc
     8521 cggctgcgag gacgtcccga ccgaacagca ccacgaggcg ccgcacgccc caccgccagc
     8581 acaacgccac ccaacccgcc ccgacaccga ggaagcagcg caccatgacc acgtcagccg
     8641 accccggcgg cctcgtgccg ttcatcaccc accgggaagg cgaagacgca gcccccgaca
     8701 acctgatcct cctcccccac tcagacggcc gcctccacct gcactacctc gacgaagacc
     8761 cccgcgaccg cgacatccac ggcgtgctgt gggcacgctg ctccttcaac cccatcgacc
     8821 cgcacggcca gcccaccggc cgccccctgt tcaaactcat gcacccctac cggcagctga
     8881 tgaccatgca gatgctgcac tgccaggtct gcaccgcacc cgcccgcacc ccactcggcc
     8941 tgatcttcct cgccggcccc cacgaccaca ccggcgcccc acaggtcctg accaaccagc
     9001 cgcccgtgtg cgcccggcac gtacgcaccg ccgcacgcct gtgcccccac ctcgacggca
     9061 cgccgaccgt ctacctcgcg cagagcgcac cgctgtacgg agccaccggc accctctacg
     9121 gactcggcac ccacggcact cagcccatcg cgcagccagg cccacccctg ccctacagcc
     9181 accccgacat gtcctgcttc ctcgcctctc agcagatccg ccgcctcgcc tccttccgct
     9241 ccgtcggcct cgaggaactc ttggaagcac tcagaccaga atccgcatag ccctctgtcc
     9301 gactacaggg ccgcctcgag cgcgcacgag gggcccgacc ctgcccgccc ggtccccatg
     9361 acgcccctgc gtctgggcgc ccaggcaacg gcgagctctc aacgtcccca caggcagccc
     9421 gcttgcaccc cacagcttcc cggagcgctc ctcgcgccgg gttggccaga acctgcgcga
     9481 cgcgatcgcc ggcctgccgg atccgcgtcg ttcgccaggt cactggcagc gccatcacat
     9541 ccgcgacatt gaccgatcac cgggagttgt tatgacgcgc aacgtcaccc acggcaccac
     9601 ccagatccag gagccggccg tacctgagcc ggacgggttc gacctgaacg tcagcttgct
     9661 ggaggtcgcc gacgccgccg ggctgaccaa cctgaccgac gacggttgcg gcagcacctg
     9721 cggcgcctgc accaccaacg tcgcctgacc tgcaccatct tgccctggct gggctcgggg
     9781 tgccgtaacg ctgacggcgg gcggcacccc gggctcacgc acccccaacc ggctcaagga
     9841 ggtatccgtg gctgacccat cagcgttccg ggctggtgcg accgccctcg tacgcgccgt
     9901 cgcccggccg agcctggccc aactcccttt tcctgatttc gacgaccgct ccttcgctgc
     9961 cggggatctt gcggaagtca ccgccgggcg ccttgcctgg gtgcgctccg tctggggcga
    10021 cgctgctctc actgaagccg taaggcacgc cagtccggtc ctcgcagccc agtgtgaagc
    10081 gctgtgcagg tccgctgctc ccgacggccg cgacgtgcgc cgggtcggac tctcgctggc
    10141 tcgctatctc ctgcgcgcgg gacaccggcc cacgcctttc ggcctcttcg caggtgtcgt
    10201 caccgcggct ttcggcaccg cgaccacagc tgtctggggc gaggctcatg tgcccgttgc
    10261 acgggccagc gcagagtggc tgtccctgct ggtggagcag ttagagaaga gcggggaact
    10321 gctcccgctg ctgtccgtcg tggtcagcaa cacgtccttc gagcgtgatg gacacctgat
    10381 cgtcccgtac caggaggacg gcctggctgg ccagcttcgc gccgtcgagg cgtccatcga
    10441 actgacggca cccgtgcgga tcgttctcag cgcggcgggc tcgccgatcc gggtcgagga
    10501 actggccgga aagctgacgg cggagttccc ttccgtcgtg cccgagcggg catgcgggct
    10561 gctggcggga ctgatccggc ggcgtgtact tgtcacgaat ctccacgcgc cggccaccga
    10621 agcggacgct ctcggccatg tcctcgcgca gctcgatgct gtggaggccg gctcgctcgg
    10681 gctgttggag gggacggttc aggaactgcg ggcgatccag accggattgc agacgtgcga
    10741 cggtgcgaat gcccgggaat cagtgaccat ccggatgcgg aagctggtgc caggccttcg
    10801 ccgtcatcct ctcgcgctcg atctgcgcct ggatgcccac ctgacgctcc ccgaccaggt
    10861 ggcgcgcgag gcggagcgcg ccgcaacggt gctgacccag ctcagcgccc gcccctacgg
    10921 ctcccgcgcg tgggccgact accaccagcg gttctacgag cgctacggca tcggaacgat
    10981 ggtgcccctg caagaggtcc tcgccgacag cggtatcggc taccccgacg gataccccgg
    11041 cgccccggcg agcggccgcc gacgggtgtc tgcccgtgat gacgttttgg tgcggctcgc
    11101 acaagcggcc gcactcgacg ggcacgacga ggtggtactc accgacgagt tggtcgacgc
    11161 cttggacagg ggaagcggtc agcagcgcgt cccgccgcac ctggaaatcg gcatacggct
    11221 gcacgcggcc agcatgaagg aggcgcagcg cggccaattc accctcgagg tcacaagcgt
    11281 gtcccgtggt gccggggtaa ccaccggacg tttcgccagc gttctcggcc gcggcccgcg
    11341 cgaagcgctg tgcgcagagc tcgctgaact gcccacggcc gacaccggta ctgaccccgc
    11401 ccagctctcc ttcccaccct tgctgtccga taccgcgcat gtcgcccggg cccctcgtgt
    11461 gctgccgctg ctcatcagcc tggacgaaca ccgggaagct tgtgcggatg tgctcacccc
    11521 ggcggacctg gcggtggcat gcgacggccg ccggatgtac ctggccgccc ccgccctcgg
    11581 ccgccgtatc gaggccgcgg gaatgcacgc cctgaacctc accgagcaca ccccgccgat
    11641 ggcccggttc ctcatcgaga tcgcccgcgc ccagtgcgcc caggtgacgg tcttcgactg
    11701 gggcgccgcc gcggccatgc cctacctccc cagactgcgc tacggccgca tcgtgctcgc
    11761 accggcccgg tggcggatgg acgcctgcga cctacccggg cgggaccacc ccggcgccga
    11821 atgggacatc gcactggccg cgtggcgtga gcggcgcagg ctgccccggc atgtccggct
    11881 caccgagaac gaccggctgc tcccgctgga tctcgaccag gcctcctgcc ggagccttct
    11941 gcgccagcat ctcgaccgcg ccccctccgc ggtgctcacc gaggccgccc ctgcgcaggc
    12001 ctacggctgg agcgcaggcc gtgcccacga catcgtggtg cccctcaaaa cgacccgccc
    12061 gcctgtctgg cctgcattgc cccggccgtc cacggcccgc accctctcgc acacccagat
    12121 acagccgccc gcctcctcgt cggtgctgct ggccgccctg tacgcagacc tgcgctgcca
    12181 ggacgctgtg ctgacccggc acataccccg cctcatccgc cggctcggct ccccgccgtg
    12241 gtggttcatc cgcttccgcg accctcacca gcacctgcgc ctgcgcatcg cccttgccca
    12301 cccggacgac ttcgccgaca ccgcgcacac ggtcagcgtg tgggccgacg aactgcgcgg
    12361 cgccgggctg ctggcagacc tgcgctatcc cacctcctac cgcgaaatgg gccgctgggg
    12421 ctccgggccg gcgtgggacg ccgccgagga cgtgttccag gccgactccc gcgctgtcgt
    12481 cgcagaactc gcccagcccc ggcgcccacc tcagcgaacc ctcgtggccg cacacacgtt
    12541 cgcgatctgc tccgcgttcc tcggcagtcc cgaggcaggc gcacgctggc tgatcgacca
    12601 cgttccgcac cgcctgaccg ggcccgtgcc gcggcagcag ttcacccagg ccgtacacat
    12661 gtctaacccg cgcaatgact gggcagcgct gcgcgccact gctgcaggcg aggcgatcgt
    12721 gacggcgtgg gctgatcgcg acactgcgct cgccgcgtac cggctgcacc tcccgggagc
    12781 acacaccgag ggcatcgccc tggacgacgt actgacctct ctgctgcaca cgcacttcgt
    12841 gcggcacgtc gctgtgaact tccccgaaga ggagatctgc ctccacctgg cccgcgccgc
    12901 cgcactcgcc ttcaccgcca gcgccgggag ccagccgtga acgaacctcc ggcgatcacc
    12961 ctggccgcag ccatcgccga ccgcctcagt catcccgaca ccgcgccctg cgcagcaact
    13021 accgacgaag cccgccagca cctggcgcac ggaccgatcg gcatcgccct gctccacatc
    13081 gagctggccg cagccgggct tggcccgtgg cagcgcgcgc acaactggct ggccgccgcc
    13141 actcgccgac cgttcaccac cggagccgac agccacccct tctacggcgc ccctgcacta
    13201 gctcacgtcc tggcctgcgc cgccgaacac ctccccggcg cctaccggcg tgacctcgac
    13261 cggctggacc ggcacgtggc aggcgacgtg aagcggcgcc tggatgccgc gcaccgcagg
    13321 atcgacgccg gccgactccc ggtgcttgcc gagttcgacg cgatccgggg actgaccggc
    13381 tacggcagat acctcctgca ccgagatgca gacgcacccg ccttgcgggc gctcctcgaa
    13441 tactgcgtgc gcctggtcga gccgatcccc caccacgacg aggcgcttgc gggatggtgg
    13501 acgctcaccg gcccttccgg gcggatcgat atctccttcc cgggcggaca cggcaacaac
    13561 ggcatggccc acggagtcgg ctccgtcttg gcgttgctcg ccctcggcgc acgccgcgcg
    13621 gtcaccgtcg ccggccacca cgaagccatg cgcaccatcc tggcctggct cgaccactgg
    13681 aagacgatca ccgcatccgg cccggtgtgg ccatattgga tcactcgcgc cgaccagcgc
    13741 gcgggcctgc tcaagccctc cacaccgcag cgaccttcct ggtgctacgg caccgcaggt
    13801 ctggcgcgcg cccagcaact cgccgcgcac gccctcagcg acaccgcacg ccgcgcacag
    13861 gcagaagcgg ccctcctgga cgcgctcacc gatcccgcgc agctgcgcgc cacggtggat
    13921 gccgggctct gccacggtgt cgccggcctc gcccatctcg cctcccgcac tgccgccgac
    13981 gcctgccccg acatcgccgc cgaactgcgc gccgtcctcc ccggcctact cgccacgctc
    14041 atcccccccg gcgcagcacc ccacgaggcg acggccgcgc tcgtgaacgg ccgtgcgggg
    14101 cccggcctcc tcgatggcgc cgcgggcata gcgctggcag ttctttccgc cgccggtgcc
    14161 cagccgcccc gcaccggctg ggacgcctgc ctgctcatcg cgtaaccccg agaggaactg
    14221 gatgcccccc gaccgctggc agcagcacaa catcaccttc accgaccggc agaccgcgcg
    14281 gcaagccgcc gccgaccgca tcgcaccagt gctcctcgag gcagaaggcc agcagctcac
    14341 cggctggtgg ttcatgaaca agcagccctg gccgctgcgg tatctcgccg accgcccggc
    14401 cccggacgtg acggaggtgc tggacagcct ggtccgcgac aacatcgctc agtcctggac
    14461 gagcagcatc tacgaaccgg agaccgaagc gttcggcggt gccgccgcga tgacggccgc
    14521 gcacgctctc ttccacgagg acagccgcca cctgctccac taccaaccag ggccacggac
    14581 gttgggccgc cgagagacgg ccgtgctcct gatgagcagc ctgatgcgcg ccgcgaacct
    14641 cgactggttc gagcaaggag acgcctgggc caaggccgct gctctacgcc cgcaccccgg
    14701 caggcccgtc tccgagcggt ccgtcgcttg gccggcagcc atgcagagat tgatgtccgc
    14761 cgaagcccgc agcctgtgcc gacaaggcgg cccgctcaac ggccacgccg agtggatcgc
    14821 cgccttcgag cgcaccggta cgacgctggc ctacctggcc gtccaagggg agctgacccg
    14881 cggtgtgcgc gccgtcatcg cccaccacgt gatcttccac gccaaccgtg caggtctgcc
    14941 caccgcggat cagcacaccc tgttccacat cgcacgagag gcagtcatga gatcaagtga
    15001 caacatcgcg tccacggcag cgaccggttc ccaggccgat agcgtcgggg cagtgaacac
    15061 cgtcacgctc accacgtccg aggccgacga ggccacccgg ctccgccacg ccctggtaga
    15121 caagatccag gccgacggcc acgcccgcac cccggcggtc gaaaccgccc tgcgcaccgt
    15181 gccccggcac ctgttcgtcc cgcaagcacc gctcagcgag gcctacgcca acgcgccggt
    15241 caacatcaag tacgacaccg acggcacgtc gatctcctgc gcctcccagc ccgacgtcgt
    15301 cgccctcatg ctggaccaac tccaggccca gcccggtgag cgcatcctcg aactcggcgc
    15361 cggcaccgga tacaacgccg ccctgatcgg ccacatcgtc ggccccgacg gacacgtcac
    15421 gaccctcgac gtcgatgacg acctggtcga aggcgcccgc gctcacctcg ccgcgaccgg
    15481 cttcacccac gtcgaggcac tggcccgcga cggagccctc ggccacaccg agggagcacc
    15541 gtacgaccgg atcatcgcca ccgtgggcgc acacggcatc ccgcacgcct ggctcgaaca
    15601 actcgccccc gggggccggc tcgtcacccc tcagcggctc aagggcagcg tctcgcgctc
    15661 catcgtctac gaggagcgcg acggacggtg ggtgtcgtcc ggctctcaga tgaacacctt
    15721 catgccgctc aggcgcggca tcgccgacga cgaccggcgc gtcgtcccgc tcaccgcgga
    15781 cggcaccgta cggctccagg cccccgccgg gcaacagatc gacgccgacg ccctcaccgg
    15841 catccttcac cagccgcgca ccgaggagtg gaccggcatg acggtccgcg ccatggagag
    15901 cccggaatgg atggagctgt tcgtctcctg ctccctgccc tccgggctga tccgcatgct
    15961 gttcccggcc accgccaagg gcaccgtcct cacccaggac ccgtacccct cctccacggc
    16021 ggccgtagac aaggacgcgg tcacctacct cgcccggcgc cagtccgaga agaagacccc
    16081 cgagggcggc aaactctggg agttcggcgt catcggccac ggacccggca gcgaggaact
    16141 ggccgcgaag gtcgctgacg ccatccgcac ctgggaccgc gcgtaccgcg gccgtgaagc
    16201 aacgttcgag atcctgcccc tcgacggccc tgtgatcgag cagcagcccg gtgtcttcct
    16261 cctggacaca ccgctgaacc gcgtcctcgt cacctggcag tagcccatca gcgtggggtg
    16321 cccgccgcgt cggcgggcac cccacgccgt ccttctcacc gttcgctccc ggggagaatt
    16381 catggaccca cgcggcccca tagctcagcg cttccctctc atttcccgct tccgccccgc
    16441 ctgcctgccc ctcccacgac gcgtccacgc cctggtcgaa ctctccgaca cagcggtggc
    16501 caaagcagac ccgggcctgg cgtcctcggt ctacaaccag gccgctctcc tcgcctccga
    16561 catcgggctt cctcatctcg cacgcacgtg gtgccaccaa cacgccgccg cctacctgca
    16621 tgccgcaccg ctcccggcaa tgagcgcgat ccgggcgctc gaaccggtgg tcaacctggc
    16681 ccgcctccaa atccgtgcag gtaacaccga ggacggcagg caccgcctgc tcacgctcta
    16741 caaggccatc agcgacggca cagacgccca gttcgaggac atccacatcc ccgccgagct
    16801 gaccaccagc gacacagacc gccacgaggt gcgggcatgg ctgtggcggg tggtcctggc
    16861 cgacggcacc cgcaccctga ccaccgcagg ccgcttcgac gaggctttga cccacatcga
    16921 aacgcaccac ggcatcggac agcgcatgct cgacggccgt caggtcgccg tcatcgcggc
    16981 cctcggccat gaccctgctg gcgcagccga catcgtggca cagacggccc ccggcgagcc
    17041 ctgggaaaac gccgtcacct cctgcctggc ggtgatgtgc aaccagctcg cccttcaccc
    17101 cgccggcccg ccgctctccg aactcgtgaa cacctacatc caacgccagc cccaccccgg
    17161 cacgaccgtc ttcgacaccc gactcggcct gaccatcctc gatctccacg accaacccaa
    17221 cagttcggcg gcacatcgca tcgccaagga actgcaccgg cgaagcatca tcgcgaccga
    17281 cggctacgcc gcgcgcgagt gcctggcgaa ctctcgtttc accgaactgg tatccaccca
    17341 ggaaactcga gcaagccgcg agctaacccg ctcatgcgcg ctcggcagcg gccacctgcc
    17401 cgccccgcat cccacccaac tgctccgagc cctccggttc agtgatgagg tgatccgcgc
    17461 ggccgcggcg gagctgcggg cggcgagacc atcctcgcgg gcgcggggtg caggacgccg
    17521 gtcgtacccc tgacatcgac gtggcgagac catccccgcg cccacgggga tggttccaac
    17581 tcgacgacgt cccggtcgac ttcctgatgg acgtcaaccg tcacgccgca tgccagacct
    17641 ggccgtgatc ctcacagccg agcccgaccg aatcgccgaa cgcggtatta cccaccggtg
    17701 gcgtctcaac cccaccgacc caccccggga agtcgatctc taccgggaaa cggcggccta
    17761 cctcacgagc aaaggggtcc gcgtactact gctcgacaac agcgcctaca ccccatcgga
    17821 cgtagctcgg agaatcgccg acctcatacc tcctctaccg ctactgaact taaaagcgtg
    17881 atgtcggttg ctaggtcagg tggtcaccgc ttgcgattgg ggctccactc gtaagctcct
    17941 ggtgccgtct cgatgacttc gcggggccag gtcagtcgga cctgttgcag gcgcccgcgg
    18001 tgctcgtcga tccagtcttc ctggggtcgg gttcccaggg ctgtcgtaag gcggtccggg
    18061 tcgctgacct ggatcgacag ccagccgtct tcgtgcacgt ggatgtcgag gatcagaccg
    18121 cggtctccgc cgatgctgac cgtctggcct ggtcccaggt tggacagctc ctgctcccag
    18181 gagtccaggt catgctggaa gaggtaaagg tcgagccggg catcgacgaa actcgcggag
    18241 acgagcacgt ccgcgtgcag aatgtcgtgg ccggtcagca cgcccggctg gaaccgtcct
    18301 gtgacgcgca cgatacagcg gttcccatcc ggatcggcga ggtggatcag atccatcgga
    18361 gcaggttccg tcattgagtt actcgctttc gtgcgctggc gtgggctgca tcgtctccta
    18421 tcgccggacg agcgaaacag tcaggcccgg ccctggagag tcacgtgccc aggggcccaa
    18481 ccggtgccgg caagatagcc gtcgatcacg tctggccggt actggagctt cttgagccga
    18541 cgcttgaccg cgcggatgac ttgaccaagg ctggcggcgg caaggtttcc gatgtcgcgc
    18601 ttgaccaggg accacacgcc ctcggttggg ttgaggtcgg gcgcataggt gggcagctga
    18661 acgacggtaa gccactcggc gttcgcgtcg atgaactcgc gcagcggctt cggcagatgc
    18721 agtcggacgt tgtcccagat cagcacgatc gggctaccca gctggatgtg gccacggacg
    18781 atcaaatcac ggaaatcgca ccagccgaag cccttcggct ggcccttgcg cccgccgtat
    18841 tcccggaccg catagaacag ccgggaccac tcaccaggct tgtagcaggt catgcccacc
    18901 atcgacactc gaccggaacc gcggccgcgc acccacacca ccggcgtgca gccacggcgg
    18961 ccccaggtcc tggcacgcgg cgcagtcatc gactgcccgg cctcatcctc gaagacgatc
    19021 caggcccccc gctccgccgc gatgctctta cccgcggcca tgtctccttc ttccagactt
    19081 cgaccgaggt gtcgtcacgc tcgatggccc tccgggcagg ctgctgccac gaccagccat
    19141 gccgcttgag cagtagccat gtgccctcga ccgtgtacga gacgtggaac aggcaaccga
    19201 tcagtgtctt aatccgatcc agggtccacc actggtccgc ccagccgtgg atcagcggtc
    19261 cgcgctccaa ctccctttcc agccggacga tctgcgtatc actgagcctc ggccagcccg
    19321 gagatccctc cgacaggacg ccagccttct cacgctcgcg ccactgacga cgcaagaacg
    19381 cggcctcgtc ccgcgaatcg cgcgccgcgg agtcgagagc ccagcccgcc tcggccgtca
    19441 tcgttgggtg atcgaacgga ccatgtcgtg gctgagcggg tgccgtcggc tccatcggcg
    19501 ctacgagcgg aagcacgagc acttcattgg cttcactgag atcgcggtca tgctcatctg
    19561 cctccgacgc ctgggtgtca gcgccggccg gtagcgtctg ccaggtgacc gacgacgccg
    19621 tcatctggaa ccggctcgcc gccttgctgc cggaggctga agcccaggac gtcaaagact
    19681 gctgggacat cggagagcag gaggctggac ttggcctgct cgtctccggc atcctcggcc
    19741 accagatgcc gatcagcgag acagacaggg ctcagatctc cgtgctcgcg gagacctggg
    19801 gcgagcggga ggccctgaca ccccagatcc ttcagttccg tgatgaagac gaacccggcc
    19861 cactgaagtt gatcgaaggc gacggaagca ccgtcccgga ggcaataggt ggggccgcac
    19921 aggacctggc cggtctcgtc ctggtcccct ggatcgcctg cacgagatgc ggccaggtcc
    19981 tgatgcgggc ccattcccga gaaagctggg gagacctctc ctacctggca cggcactacg
    20041 tcatcactac gccgaaccgg gccaccgtct cgctgctctt ctctgccgac tccgctggcg
    20101 aggccttcgt ttccctccag cgtcagtgtt cagacgcacc ataagaaacg gcgtgttaga
    20161 ccgtgtccta tgtggtgagg cgtcgttggt ctgttcatgg ggcggggtac gtggagttgg
    20221 attgttccgg acggcctgtg ggagatcgcg aagccgctga tcccaccttc gaaggtgcgg
    20281 ccgcagggcg gcggaacgca ggacacgcct gatgaaacgc tgttcgcggc gatcgtctac
    20341 gtcctggtca gcgggtgcgc ctggcgggcc ctcccgccct gcttcggcat atcgaagtcg
    20401 accgcacatc gaaggttcct gatctggtcg agagccggtg tgtggggccg gctgcacgaa
    20461 gcggtcctgc accggctcga cgacgccgac ctggtcgacg tcacccgcgt cgtcctcggc
    20521 accgcccacg tccgcgctaa aaaaggggcg aacacacagg tccgagcccc gtggaccggg
    20581 gcaagccggg ttccaagatg cacgtcctgt cggacgcgaa cggactgcca ctggcggtca
    20641 gcctctccgc cgccaacgtc cacgacagcg aaggcctgaa gcccatggtc gcgggccacc
    20701 aaacgaaaca cgacccgttt cgcggacggc acttcaagcc ccagcgactc catgcggaca
    20761 aggcctacga cataccccac ctgcggaaat ggcttcgggg aaagcgcatc ggcgtccgca
    20821 tcgcccgcaa ggggatcgag tccggcgaac gactcggccg ccgccgatgg gtcatcgagc
    20881 gaaccatgtc ctggctgtcc ggctaccgac ggctgagccc ccgctacgaa cgcaaccccc
    20941 gcaactacct ggcattcctc ggcctcgccg ccgccctctg ctgctacaag cgactcgtcc
    21001 gcctcaccac ataggacacg gccttaggac ggcaggaacc gccggcacac gcatcccatg
    21061 accgcaagtt cccccggtag ctccggtcgg ggcagggaac aagagctcga cccgtgtggt
    21121 cactcatggc attgtctcaa tctgacctga tgcagccgct ggcccatctc agtcgaacct
    21181 gttcaccgtc ctgccagtcc acggatctat tccagtgtca attattcgct cctcatctct
    21241 aaaattcaag aatcgggcac tttgaatccc ccacagggtc tcatcactta caggacattc
    21301 agaaaattcg ccactcagta gcttcaacaa aaattccacc atcccacatt tgtggatttt
    21361 ccagcccccg ccatgtcgtt cccataccgc aagaggccat tggtcggggt cagctcctga
    21421 ggtaacccag cacagcatgt ctgcgctgtt cgtctgtccc cagacgagca tgtcctccaa
    21481 tctatttctc agaccctcat cgacttcctg ccacgtgttc atggatgctg accgacgggc
    21541 atggcccggc aagcgcgtaa gtgacagcgg ttcaccagta gtcccagggc gcgggattga
    21601 gataaagagg ctctcttcga tcgtcccagc accgaatgca gagacaaact ccatatagtc
    21661 ttccgggaag gattccacct gcagttcagc cgcagcggcc cgccagtcga ctacatcacc
    21721 cctctctcct tcctcgtgaa gcagtgcaag ggatccacgc aatcgcctca gaagatcgtg
    21781 cataacaccc tccctgaaaa tcctctaccg atcaacggtc acgcgaccta cggggtggta
    21841 cctgtcggaa caggccctcc ttcaacgttg accaagccaa tattgtacgt tcccttgaac
    21901 ttgttgctgt acatcatgtt cggtattggc acggccagcg acagtcctgg ttttccaccc
    21961 aaagtaccgt acgcagtcag atcatatgaa actggtacag ttcttgagcc tttgtagacc
    22021 gggaccacct tgtagtggac gatctctccc ctgccaatcg ctcggactac ctgatcttca
    22081 tagacagcca tgttctcggc aacgccgggg tcggtcgccg caatggagtg ggcattggcg
    22141 gcgcgagcac acgtggacag attcttcaaa tttcgaccgt caccgctcag gctcttagcg
    22201 agcaagtgac aggcattaac ccattctccg ggaggcctgt ttcccaagta tccggcgtag
    22261 tcccgagccc actcataccc aggtggtgcc acttccttcc atttggtcgc ggatccctta
    22321 tgggtagcca gatatgcact gtccagacag gcttccacac cggtagcccg atcaccgtgc
    22381 gcactgtcta cgtcgccata ttcgacccag cccgcaccgc cacgccgaca gtctccaccc
    22441 gaattgcgat ctgtcccggt ctccgcattg tcgggcagaa gcgcattcgc agccatattt
    22501 ccaagcggga taaatacggc gacgtcgacc atgtccgcta ccgcttgaga agtaaccgtt
    22561 ctacttacgc cttgatcaat tgtgtatgta gcgtccacct tcgctctcgg tatagaacgc
    22621 ttgggtgccg gcttggggcg cggacccttg ttggggttct gcggcggacg tggcgttcgg
    22681 ggagccgtag tgcccttgct ttgcttgggc gtcggagtcg aacgcttagg agcggtattc
    22741 cttccgttca ccggccgtcc aatgggtctc cccttgccgg ggctgctgga cggtcggccg
    22801 ctgaccggac gcgtggggcc gcggtaagag ccgaggttca tctctctttg tattctgcgg
    22861 gcttgtgcgc ggctggcagt tcctcttccc gtactaccgc cgctgttggc gcggcttcgc
    22921 gaggatgagg agcggcgggt ggtgaagcgg ctgctgccgc ggaagcccaa ggttcccgtt
    22981 gagcttgctc cgcttccgat atcgcgttgc cgtatgtgtc ctgtggggtc ggtcccgttc
    23041 aacggtccgc cgttgatgta gccgtaccgg ttggcttctg cggagggttc cgggtccagc
    23101 tgccatgtgt cccgagatcc gaaggatccc gtctccggct ggtaccagcg ggcggccatg
    23161 ttgacgtcgc cgctcgccgg gtcggtccag cctgactggt agccgacggc cggtgtggtg
    23221 ccgttggttg ccgtctcctt gccgaagggg tcgtaggacg tggagccgct gaccgagttg
    23281 ccgtccgcgg tcaggccggc gaccaggtcg gtgtgctggt cggtcagtgc ccactgcttc
    23341 gtggggccgg ttgacagaga gaggagggtg ccctccggtg tgcggttgta gtcggtcgtg
    23401 ccatcgcccg cgaggttgtt ggagcctccg tcgtaggtga aggctgtcga gcctcgagtc
    23461 tggacacggt cgagggagtc gtaggcgtat gttgtgccgc cgtcggtgat cttgcgttcg
    23521 aaggcgtcga aggtcagtgc acgggccgct ccgctgccgg tgctggtcga ggacaaagtg
    23581 ccgcgtgcgg tgtacgtgta ggccgtcgtg ccgtccgtca gctggcggtt gcgggcgtcg
    23641 aaggtcgctg ccgtcgagcc ggccttggtg cggttgcccg ctgcgtccca ctcgtacgac
    23701 gtggttagcg tggcgtcctt cgtccaggag gtcatgcggt tcgcgtagtc gtaggtatag
    23761 gtgttggtgc ctgcgcctgc cgtgcccgtg gtcttcttcg acgtcaggtt gtcgtccagg
    23821 tcgtagccgt acgtcgtgga ggccacgctc gtcgcgccgt ctgccgacgt gacggcgtcg
    23881 gtgttcaggc ggcccagctc gtcgtagccg taggtgcgct tggcggtgac cgtgtagggc
    23941 gctgtgcctg tcgggctggt ggcgtactgc tccaggctgg ggcggcctgc cgggtcgaag
    24001 tcgtacagga cgttgttgcc ggtgatggag tcgcggacgg tgtcgatgcg gccggcggcg
    24061 tcgtaggtgt agtcggtggt gcctgctgtg gtggtgcggt gcgtcatgct gccgtcggcg
    24121 ttgtaggcgt acgtggaggt gccgcccgga cctgtggcgg tcagcagcgc gccttggtcg
    24181 ttgtaggtgt aggtgttgcg ggtcaggccg tccgcggtgc cgatcgaggt caggcggccg
    24241 gtcaggtcgt aaccgagggt gcgggtcgcc gtcgttgcct ctgcgcccgt gcccgtctct
    24301 gtcgtcaggc ggccgaggcc gtcgtaggtg cgctcacgtt tcactccgcc cggcaggagc
    24361 tcggtcaccg gctggccggc cgtgtcgtag acggtcgtcc aggtgcggtc ggcagtgttc
    24421 gggtgtgcgg tcgtggacgg ttcgatcgtc gattcgggca ggcccaggct gttgaaggtg
    24481 tagagggtct tgttgccgcg gccgtccgtc agccgggtga ggttgcccgc ggcgtcgtag
    24541 ccgagtgtcg tcgtgatcga tgtcgtggcg gtgaccggtt cggtctgggt cgtggtgcgg
    24601 cccagtgcgt cgtacgcgta cgtcgatcgg gctttgctgc cggcaggggt tgacgccgtg
    24661 cggttgcctt cggcgtcgta ttcggcggtg tcggtgcgca gggcggtggt gccggtgccg
    24721 tagtcggtgc tggccgtgat gttgccgagg gcgtcgtagg ccgtggtcgc gcggcggttg
    24781 gtcgcgtccg tggtctccgt ctggcggccc aggccgtcgt agtcgaactt ggtgatgccg
    24841 gccgggtcgg tcagtgtttt cggttcggcg gccgcgttgt aggtgctcgt cgtggtgatg
    24901 cccgccggtg tggtcgacgc ggtctggttg cctgcgtcgt tccaggtgta gcgggtgacc
    24961 aggttggcgg tggtcgggta gcgctcgatg ctggtggccg tcagctgtcg gcccagttcg
    25021 tcgtaggtgg cttcggtgcg tgcgcccatc gggtcggtga ccgagagctg gaggccggtg
    25081 ggggtccagg tggtgcgggt gactccgccg ccgtccgcgc tctcggggtt gagcaggtcc
    25141 gagtcggttt ccgccgcgac agctgtggcg gcgtcggcgg ccgggtctgt ctgggcggtc
    25201 agctgcccga gctggtcgta ggcgtagcgc gtgacgcggc ccagggggtc tgtcgcggtc
    25261 tgcggctggc cgagcgctgt gtaggtggtg cgggcggtcg ccgtcagggc ggtggtggcg
    25321 ccgggagggg tgtagtcggg cagggtgatg gcggtggtgc ggccgaggcg gtcgacttcg
    25381 gtgcgggtca ccttgccgcg ggcgtctcgt acggcggtgg cttcgccgaa ggtgttgtat
    25441 ccggtgagcg tggtcggctt tgtggtggtg gccggcgcgc cgttctcctc ggtctggacg
    25501 gcgggggcgg tctgctgcac cgggcggccc agcgcgtcgt ggcggtaggt ggtggtgtag
    25561 gcggtcgggt cggcgccgtt ggcgttgccg cgcgggctga ccgaggtcag cggcaggccg
    25621 cggttgtcgt aggtgccggt ggtgatgtgg gtggtggtgg cgtcggtgac ggtctgcttg
    25681 gtgacgttgc cggccgggtc gtactcggag gtggtggtga gcttcttggt ggcggagatc
    25741 gtctgggtct gttccttgac gcggtcgtcg ccgtcgtagg tgtaggtggc ggtgcggttc
    25801 aggccggagg ggtcgagcac gctcgtctgg gtgcgtccca gggcgtcgac ggtgaaggtc
    25861 tgggtggtcg tgccgccgcc ggtgacctgt ttggtgaggt tgcccgccgg gtcgtaggtg
    25921 tcggactcca gcacgatgtc gtggcggctg ccgtctgcct gggtgacctg cttggcggtg
    25981 gtcgtcgccg cgaggccgtc gtcgtagtag gtgtaggcgg tggtggcgcc catcgcgtcc
    26041 gtggtggacg caaggcggcc ggccgggtcg taggcgttgg agaccagcgt caggtctttg
    26101 gtggtaccgg acgggtcgcc tgtccagtcg tccaggatcg tggtggcgtg ctggtcgccg
    26161 ggagtgtagg tgtaggtgac gtgggtgccc gccgggtcgg tcgtgccgac ggtgcggccc
    26221 aaggtgtcgt gttcgtactg ggtggtgtgc tgctcggcgt cggtggcgct gtcgttgagg
    26281 ccgtgggcgt cgtagtggta gct
//
