LOCUS       NZ_BMSI01000012        21128 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence12, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000012
VERSION     NZ_BMSI01000012.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 316734)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 150276
            Orig. end                         :: 171404
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="1"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11128](+)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11128
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     misc_feature    420..434
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.96"
                     /tool="antismash"
     gene            complement(712..1218)
                     /locus_tag="IE189_RS26815"
                     /old_locus_tag="GCM10010496_54630"
     CDS             complement(712..1218)
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999620.1"
                     /locus_tag="IE189_RS26815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54630"
                     /product="MaoC family dehydratase"
                     /protein_id="WP_189925762.1"
                     /transl_table=11
                     /translation="MQFGRTYEEFEVGATYKHWPGKTVTEYDDHLFCLLTMNHHPLHMD
                     TNYAEKTTDFGKNVVVGNYIYSLLLGMSVPDISGKAIANLEIESLKHVAPTFHGDTLYG
                     QTTVLDKWPSKSKNDRGIVHVETKGYKQDGTLVCVFRRKVMVPTETYIKERGGEQPGRP
                     ELQEG"
     gene            complement(1224..2243)
                     /locus_tag="IE189_RS26820"
                     /old_locus_tag="GCM10010496_54640"
     CDS             complement(1224..2243)
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890463.1"
                     /locus_tag="IE189_RS26820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54640"
                     /product="CoA ester lyase"
                     /protein_id="WP_229901446.1"
                     /transl_table=11
                     /translation="MTARPSPTAALPASGSAAPLPSVNRLRPRRSCLAVPGSNPRFLEK
                     AQGLPADQVFLDLEDACAPLAKPEARHTIVKFLNEGDWTGKTRVVRVNDWTTEWTYRDV
                     VTVVEGAGPNLDCIMLPKVQNAQQIVALDLLLTQIEKTMGFEVGRIGIEAQIENAQGLN
                     NVNEIAQASSRIETIIFGPADFMASINMKSLVVGEQPPGYPADAYHYILMKILMAARAN
                     DLQAIDGPYLQIRNVDGYREVAGRAAALGFDGKWVLHPGQVEASNEIFSPSQEDYDHAE
                     LILDAYDYYTSEAGGKKGSAMLGDEMIDEASRKMALVISGKGRAAGMRRTGKFEIPEG"
     gene            complement(2240..4267)
                     /locus_tag="IE189_RS26825"
                     /old_locus_tag="GCM10010496_54650"
     CDS             complement(2240..4267)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981115.1"
                     /locus_tag="IE189_RS26825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54650"
                     /product="protein meaA"
                     /protein_id="WP_189925763.1"
                     /transl_table=11
                     /translation="MTERQKDRPWLMRTYAGHSTAEASNELYRRNLAKGQTGLSVAFDL
                     PTQTGYDSDHVLARGEVGRVGVPVAHLGDMRRLFQDIPLEQMNTSMTINATAMWLLALY
                     QVVAEEQGADVTRLQGTTQNDIVKEYLSRGTHVFPPGPSLRLTTDMIAYTVSHIPKWNP
                     INICSYHLQEAGATPVQEIAYAMSTAIAVLDAVRDSGQVPAEKFGDVVARISFFVNAGV
                     RFVEEMCKMRAFGRIWDRITRERYGIEDAKQRRFRYGVQVNSLGLTEAQPENNVQRIVL
                     EMLAVTLSKDARARAVQLPAWNEALGLPRPWDQQWSLRIQQVLAHESDLLEYEDLFEGS
                     HVVEAKVAELVEQSLAEIERIQEMGGAMAAVESGYLKSQLVSSHAERRARIESGQEKII
                     GVNIFETTEPNPLTADLDTAIQTVDPAVEARVVASLGTWRDTRYQPPFNHPRPCKALEK
                     LKEAAKGTANLMEATLECARAGVTTGEWAGALREVFGEFRAPTGVSSAPVAVPAEEGSA
                     MADVRRRVEVTAKDMGVGKLRFLVGKPGLDGHSNGAEQIAVRARDAGFEVVYQGIRLTP
                     EQIVDAALEEDVHAVGLSILSGSHAQLVPDVLERLRVAGATDIPVIAGGIIPNGDAELL
                     RAAGVAAVFTPKDFDITGIIGRIVDEIRKANKLDPLEVPA"
     gene            complement(4285..5628)
                     /gene="ccrA"
                     /locus_tag="IE189_RS26830"
                     /old_locus_tag="GCM10010496_54660"
     CDS             complement(4285..5628)
                     /EC_number="1.3.1.85"
                     /GO_function="GO:0043880 - crotonyl-CoA reductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (55-415). E-value: 3.7e-25.
                     Score: 80.6. Matches aSDomain:
                     nrpspksdomains_IE189_RS26830_PKS_ER.1"
                     /codon_start=1
                     /gene="ccrA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328626.1"
                     /locus_tag="IE189_RS26830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54660"
                     /product="crotonyl-CoA carboxylase/reductase"
                     /protein_id="WP_189925765.1"
                     /sec_met_domain="ADH_N (E-value: 9.1e-08, bitscore: 26.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.3e-32, bitscore:
                     105.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTQAILDAIQSPDSTSADFAALPLPESYRAITVHKDEAEMFAGL
                     ESRDKDPRKSIHLDDVPLPELGPGEALVAVMASSVNYNSVWTSIFEPVSTFSFLERYGR
                     LSDLSKRHDLPYHIIGSDLAGVVLRTGPGVNAWNPGDEVVAHCLSVELESSDGHNDTML
                     DPEQRIWGFETNFGGLAEIALVKSNQLMPKPDHLSWEEAAAPGLVNSTAYRQLVSRNGA
                     GMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSPQKADICRAMGAEAIIDRNAE
                     GYRFWKDENTQDPKEWKRFGKRIRELTGGEDIDIVFEHPGRETFGASVYVTRKGGTITT
                     CASTSGYMHEYDNRYLWMSLKRIIGSHFANYREAWEANRLIAKGKIHPTLSKVYSLEET
                     GQAAYDVHRNLHQGKVGVLALAPEEGLGVRDEEKRALHLDAINRFRNI"
     aSDomain        complement(4384..5463)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS26830_PKS_ER.1"
                     /evalue="3.70E-25"
                     /label="IE189_RS26830_PKS_ER.1"
                     /locus_tag="IE189_RS26830"
                     /protein_end="415"
                     /protein_start="55"
                     /score="80.6"
                     /tool="antismash"
                     /translation="IHLDDVPLPELGPGEALVAVMASSVNYNSVWTSIFEPVSTFSFLE
                     RYGRLSDLSKRHDLPYHIIGSDLAGVVLRTGPGVNAWNPGDEVVAHCLSVELESSDGHN
                     DTMLDPEQRIWGFETNFGGLAEIALVKSNQLMPKPDHLSWEEAAAPGLVNSTAYRQLVS
                     RNGAGMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSPQKADICRAMGAEAIID
                     RNAEGYRFWKDENTQDPKEWKRFGKRIRELTGGEDIDIVFEHPGRETFGASVYVTRKGG
                     TITTCASTSGYMHEYDNRYLWMSLKRIIGSHFANYREAWEANRLIAKGKIHPTLSKVYS
                     LEETGQAAYDVHRNLHQGKV"
     CDS_motif       complement(4888..4950)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS26830_0001"
                     /evalue="1.80E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="IE189_RS26830"
                     /protein_end="247"
                     /protein_start="226"
                     /score="11.1"
                     /tool="antismash"
                     /translation="GDNVLIWGASGGLGSYATQFA"
     misc_feature    complement(5923..5936)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.31"
                     /tool="antismash"
     gene            complement(6055..6870)
                     /locus_tag="IE189_RS26835"
                     /old_locus_tag="GCM10010496_54670"
     CDS             complement(6055..6870)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922867.1"
                     /locus_tag="IE189_RS26835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54670"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_189925767.1"
                     /transl_table=11
                     /translation="MPQPARSSRTPATPDAPESAAGSRAAAQRLKMRRELAAAAMELFS
                     TKGYEATTVDEIAAAAGVARRTFFRHFRSKEEAIFPDHDDTLIRAEAVLNAAPAHEHPL
                     DTVCRGIKEVMKMYAARPEISVARYRLTREVPTLREAEIASVARYERLFTRYLLGHFDE
                     HAHDDDANDDPLLAEVAASAVVTAHNHVLRRWLRADGQGDVESQLDHAFAIVRKTFGTG
                     IGAGRSGAGAPRQAPAAVSAHGEVLVTVARTDASLDEVMRTIEQALKER"
     gene            complement(7007..8815)
                     /locus_tag="IE189_RS26840"
                     /old_locus_tag="GCM10010496_54680"
     CDS             complement(7007..8815)
                     /EC_number="1.1.1.35"
                     /GO_function="GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119123.1"
                     /locus_tag="IE189_RS26840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54680"
                     /product="3-hydroxyacyl-CoA dehydrogenase family protein"
                     /protein_id="WP_189925769.1"
                     /transl_table=11
                     /translation="MAAPLSDTPLSPLRSIAVIGLGTMGTGITEVLAKAGREVVGVDIS
                     EAQAARSLAALEASTARAVERGRLTEQERADVLARVRVSTDLRTAADADLVIEVVPESY
                     EIKQQIFRELDGLVRPETILATGTNALSVTRLAAESARPERVLGLHFFNPAPAMKLVEV
                     VSSVLTAPAAVTAVTNLALDLGKEPVAVGDRPGFVADGLLFGYLNQAAAMYEARYASRE
                     DIDAAMRLGCGLPMGPLALLDLIGVDTARTVLEAMYAESHDRLHAPAPVLKQLSEAGLT
                     GRKSGRGFYTYEAPGSATVVPDALTPLSGAAGGTGSRAVSSVGVAGSGTMASGIAEVFA
                     KAGYDVVLAARSEEKAQTAKARIGKSLARSVDKGRLTAEAAALILDRITPAGSYDAFAD
                     VDLALEAVAEDLEIKQQLFAALDKVCKPGAILATTTSSLPVVACARATSRPQDVIGMHF
                     FNPAPAMKLVEVVRTVLTADDVHATVREVCGRIKKHAVDCGDRAGFIVNALLFPYLNNA
                     IKMVQEHYATLDDIDAAMKLGGGYPMGPFELLDVVGLDVSLAIEKVLHREFRDPGLAPA
                     PLLEHLVAAGCLGRKTGRGFREYARR"
     misc_feature    complement(9120..9137)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.76"
                     /tool="antismash"
     gene            9204..9779
                     /locus_tag="IE189_RS26845"
                     /old_locus_tag="GCM10010496_54690"
     CDS             9204..9779
                     /EC_number="4.3.2.2"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994090.1"
                     /locus_tag="IE189_RS26845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54690"
                     /product="adenylosuccinate lyase"
                     /protein_id="WP_189925771.1"
                     /transl_table=11
                     /translation="MDEELRSLTERLRREAGATAAFERLARTEDLGELAGVLTESGQPL
                     WARELAAFRLGLAGDRRAFEALVLLLNHRDPPRCSGAAYALARLGDPRTARAAATLATN
                     ELRVAYALHPVRLLVELRAPESVPALITTLRRRLRPHDPYRRVALACVEGLGTLGDDRG
                     RPVLEDALAHPALAEAAVHALARIPGQR"
     misc_feature    9237..9239
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..11128
                     /locus_tag="IE189_RS26850"
                     /old_locus_tag="GCM10010496_54700"
     CDS             10001..11128
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125556.1"
                     /locus_tag="IE189_RS26850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54700"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_229901447.1"
                     /sec_met_domain="indole_PTase (E-value: 1.1e-101, bitscore:
                     334.5, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSAQLPDEISDLSARRDPDITFGGFLEEKWTEVCRGLGVDQWET
                     ETVLRDLREVIHPWGSRPVGTRCDPPSFVSADGFPAELSVSWKGGRPEVRILFESLGDD
                     RTPLGCQEAGRELTRRLAGSPGTDISRYLGIEDLFLTSAPDRYRATLWHSLAWRPGKRP
                     HYKVYLNPQVHGLDHAYDVMAQAMERLGLADAWEPVGRRGAELARRGHELELMALDLDA
                     GDAPRVKVYYRHRPMPMDELDTVAELAHRYEPVRAARARGVIYGRDGGTVSNEPMTCLA
                     FREDTSGPQEANVYLRLPDNTASDAEAAERIARLMELEGIDPRPHAEIVRRLTAGRPAG
                     AGGLQELCSYRTISPEMPADIGVYLRFGTYGGPVL"
     gene            complement(11185..11580)
                     /locus_tag="IE189_RS26855"
                     /old_locus_tag="GCM10010496_54710"
     CDS             complement(11185..11580)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996590.1"
                     /locus_tag="IE189_RS26855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54710"
                     /product="RidA family protein"
                     /protein_id="WP_189925773.1"
                     /transl_table=11
                     /translation="MSATTRITAPDGVAAATQYSHVVMGTGRFVAVAGQLPLDEDGRPV
                     GAGDPRAQARQVFENLRRCLAAAGATFDDVVKLTYFVTDMAHMPAIRAARAGHIPDDRL
                     PAASAVQVAALVRPEFLMEIEAFAVVG"
     gene            complement(11637..13226)
                     /locus_tag="IE189_RS26860"
                     /old_locus_tag="GCM10010496_54720"
     CDS             complement(11637..13226)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (93-461). E-value:
                     1.3e-27. Score: 88.9. Matches aSDomain:
                     nrpspksdomains_IE189_RS26860_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071304.1"
                     /locus_tag="IE189_RS26860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54720"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_189925774.1"
                     /sec_met_domain="PF00561 (E-value: 2.9e-36, bitscore:
                     119.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPRAAVLCAAAAVVAGTVTAVPAAADPSRPAQSAPAPSAPAARL
                     DWKSCGITGRPKLQCASLEVPLDHARPDGRRITLALSRVPHTAKTFQGPLLVNPGGPGG
                     QGLSLAGFVASALPKAVAAQYDVIGFDPRGVGRSTPALDCEPGHFAPVRPDSVPDTEAV
                     ERANLTRAKSFAAACAKKYADVLPHIDTLSTVRDMDAVRAALGARQLNYFGYSYGTYLG
                     AVYAKLYPHRVRRLVLDSVVDPSGVWYEDNLTQDLAFNDRHRALMAWIAKYDKTYRLGT
                     DPEKVETEWYAMRAAVGAKPAGGQVGASELEDTFLPGGYYNGYWPRLAEAFAAYVNDKN
                     ADPLIAAYKNLAAVDAAGDNGYSVYTAVQCRDASWPRDWDEWRTDNWSLYAKAPFMTWS
                     NAWYNAPCAFWPTRPVGPVDITNGALPPVLLFQATEDAATPYEGGATVHALLRGSSLVV
                     EEGGQNHGITLSGNPCLDKHLAAYLTDGTVPRGTAGVDAVCAAQPDPVPTTSKVASRTH
                     GSVLHGLLGFRG"
     aSDomain        complement(11844..12947)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS26860_Abhydrolase_1.1"
                     /evalue="1.30E-27"
                     /label="IE189_RS26860_Abhydrolase_1.1"
                     /locus_tag="IE189_RS26860"
                     /protein_end="461"
                     /protein_start="93"
                     /score="88.9"
                     /tool="antismash"
                     /translation="PLLVNPGGPGGQGLSLAGFVASALPKAVAAQYDVIGFDPRGVGRS
                     TPALDCEPGHFAPVRPDSVPDTEAVERANLTRAKSFAAACAKKYADVLPHIDTLSTVRD
                     MDAVRAALGARQLNYFGYSYGTYLGAVYAKLYPHRVRRLVLDSVVDPSGVWYEDNLTQD
                     LAFNDRHRALMAWIAKYDKTYRLGTDPEKVETEWYAMRAAVGAKPAGGQVGASELEDTF
                     LPGGYYNGYWPRLAEAFAAYVNDKNADPLIAAYKNLAAVDAAGDNGYSVYTAVQCRDAS
                     WPRDWDEWRTDNWSLYAKAPFMTWSNAWYNAPCAFWPTRPVGPVDITNGALPPVLLFQA
                     TEDAATPYEGGATVHALLRGSSLVVEEG"
     gene            complement(13386..14429)
                     /locus_tag="IE189_RS26865"
                     /old_locus_tag="GCM10010496_54740"
     CDS             complement(13386..14429)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119128.1"
                     /locus_tag="IE189_RS26865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54740"
                     /product="Rv2578c family radical SAM protein"
                     /protein_id="WP_189925775.1"
                     /transl_table=11
                     /translation="MRWENLTVETRHDRPADAALFGADAVTTRTFDTPEFAGITFHEIR
                     ARSILNRVPGASRMPFEWTVNPYRGCTHACVYCFARKTHSYLDLDTGTGFDTQIVVKVN
                     APELLRRQLASTRWHGEHVAMGTNVDCYQRAEGRYRLMPGILTALRDRANPFSILTKGT
                     LVLRDLDLLRQCAEVTDVGVSVSVGFIDTELWRTVEPGTPAPERRLDVVRTLTDHGIGC
                     GVLMAPVIPFLGDQPDRLRATVRAIAASGATSVTPLALHLRPGAREWFMAWLARHHPYL
                     VRRYERLYADGAYAPKWYQRRITRQVHELAEEYGIGPTRAGMPRRVPPPEPVEEPTGPG
                     PTQLTLI"
     misc_feature    complement(14460..14474)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.08"
                     /tool="antismash"
     misc_feature    14461..14474
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.77"
                     /tool="antismash"
     gene            14642..15085
                     /locus_tag="IE189_RS26870"
                     /old_locus_tag="GCM10010496_54750"
     CDS             14642..15085
                     /NRPS_PKS="Domain: Polyketide_cyc2 (3-146). E-value:
                     6.1e-23. Score: 73.7. Matches aSDomain:
                     nrpspksdomains_IE189_RS26870_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038765.1"
                     /locus_tag="IE189_RS26870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54750"
                     /product="SRPBCC family protein"
                     /protein_id="WP_189925776.1"
                     /transl_table=11
                     /translation="MAQVEATTERVVAADPEKVFDTIADYSDARGKLLPEHFSEYEVRE
                     GGDGEGSLVHWKLQATSKRVRDCLLEVTEPTDGELVEKDRNSSMVTVWRVTPAGEGRSR
                     VVVTSTWNGAGGIGGFFEKTFAPKGLNRIYDLILANLAAEVEK"
     aSDomain        14651..15079
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS26870_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="6.10E-23"
                     /label="IE189_RS26870_Polyketide_cyc2.1"
                     /locus_tag="IE189_RS26870"
                     /protein_end="146"
                     /protein_start="3"
                     /score="73.7"
                     /tool="antismash"
                     /translation="VEATTERVVAADPEKVFDTIADYSDARGKLLPEHFSEYEVREGGD
                     GEGSLVHWKLQATSKRVRDCLLEVTEPTDGELVEKDRNSSMVTVWRVTPAGEGRSRVVV
                     TSTWNGAGGIGGFFEKTFAPKGLNRIYDLILANLAAEVE"
     misc_feature    15196..15213
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            15248..17674
                     /locus_tag="IE189_RS26875"
                     /old_locus_tag="GCM10010496_54760"
     CDS             15248..17674
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071307.1"
                     /locus_tag="IE189_RS26875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54760"
                     /product="MFS transporter"
                     /protein_id="WP_189925777.1"
                     /transl_table=11
                     /translation="MGGITPVRDEPVTAAPAEDPPAAPDTPRTPGPRGVRLVFFSLVLA
                     LLLAALEQMIVATALPRIVGELHGADRMSWAITAYLLTATVGLPVYGKLGDLLGRKGVF
                     QFAIAVFVIGSALAGRAGTMDQLIAFRAVQGIGAGGLMIGVQAIIADIVPPRRRGRFMG
                     LVGAAFGLASVAGPLLGGYFTDHLSWRWCFWFNVPLGLITLAVVGVALKLPKPTAPPRF
                     DVLGALLLAAASTCLVLLTSWGGTEHAWDSGVVLGLGAGAAVATALFVVVERIVAEPLI
                     PPRLFKDPVFNVTALVGLVTGVALFGAAGYLPTFLQMVDGATATGSGLLMLPLMGGVVG
                     ASVLSGQLVSHTGRYKLYPVLGSALAVLGMALLSRLDADTPRLRYSLWMAVLGAGIGLV
                     LPVLVLAVQNSVRPADLGAATSATTYFRQIGGSIGAAVFGTLFAGRLTDALRTGLPAHA
                     TGALPDPGSLTPQLVHALPPALRDAYVRAYADAMPRVFLYLVPVLAVGLLIACFLKERP
                     LVSQNAAEAEPAPGNTPPPQALPHRSGRGRAISSRSPHASGLPVRGTVRHPDGTAVPSA
                     ALTLVDGGGQQVGRGASGPDGRYALSTPGSGAYVLIAAAGGHQPQAVSVTVGERPVELD
                     VVLGGAGRLAGQVTTADGAPVPEATVTLTDVHGEVVAGTRSGRDGGYLITELVAGEYTL
                     AAAAAGHRPAAVPVSVQASRETRQDVELAGGALLRGTVRAPGGRPVEDARVTLLDAAGN
                     VVDTLTTGPDGTFRFVDLSSGEYTVIATGYPPVATVLRMAGGGRTERDLRLGHED"
     gene            17815..20337
                     /locus_tag="IE189_RS26880"
                     /old_locus_tag="GCM10010496_54770"
     CDS             17815..20337
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972494.1"
                     /locus_tag="IE189_RS26880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_54770"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_189925778.1"
                     /transl_table=11
                     /translation="MDRGTERDAPPSRGADGGAADGPAGAGRVPLAVVVVDREGLVSHW
                     STGARRLFGVAKEEAIGRPAIDLLPVSGALPDPEDDLPDGGHGGYEGYAAYDGLGPGLD
                     SSLDRGLGYPAAGRARLSVPGGSGSAARVPGGRGGSERVDVLWWAYPLVGPGTERLLVL
                     AADAAALRRDDPADPLAVERIAPAFALHTDFPGATELARRLPEILPSMSVGDSARIVGQ
                     VLELGYPVLEFSQNDRIPVTPDWGVARRVERRARRERAARAAAEGAVVPQDPDDEGEDL
                     EYVAVRERLEFLNEVSGKIGTTLDLSRTIEEVSRAVVPRFTDVAGTYLREQVVAGEGFP
                     DGVPDTTTLWHRVAVEHTDEPGRWDDVVPVGEAMPFPAHTPFFQCMTTGLPVLVPRIGE
                     ELGHAIASQFEKRDIRPLITGRSMLVVPLKARDVVLGFMILLRHPERAPFDDMDRVTGA
                     ELAARAGLVLDNARMYTHQESVAETLQDSMLPHIPPRMAGCDITTRYLPGTLLGRVGGD
                     WFDSVKLPGARTALVVGDVMGHGLNSAAMMGQLRTAVQTMAALDLPPAQLLRNLDDLAQ
                     RLGDTYLATCLYAVYDPIGGELHLANAGHIPPVLVRAADGRSELLELPTGAPIGVGGVP
                     FEAVRVRVRPGDRLVMCTDGLVEVRGEDIGVGLATLCESAAHPAASMDDACDTVIRALN
                     TRGGRKDDVALLLARLNGIAPDDVAERRFPRAPSQVGPARAVVREQLHVWGLDELADAA
                     ELMVSELVTNAVRHSRQNPVALRLVRGDTLLCEVEDDDHELPTLLSAGPGDERGRGLRV
                     VSALAREWGASRTAAGKSVWFELALPHR"
ORIGIN
        1 ggcgggaagg cgcaggccgt ccatgatcag ctcggtggtg tcgacgccct tgtagcccat
       61 tttgtcgatc ttgcccggga tggtgagtcc gggccgcacc tcgccgaagc cgggctcctt
      121 ctcgatcagg aaggtcgtca tcgacttgtg gggagcggtg ccctcagggt gtccttcgtc
      181 acttcggacc agaacggcca ccagggacga cgtgcccccg ttcgtcagcc acatcttctg
      241 accgttcagg acgtactcgt cgccgtcccg caccgccttc gacgtgatcg ccgacacgtc
      301 cgagccgagg gccggctccg acatggagaa ggcgccgcgg acgtcgccgg ctgccatcct
      361 cggcaggtag tggtccttct gctcctgtgt gccgtgctgc ttgagcatgt acgccacgat
      421 gaaatgcgtg ttgatgatgc cggagaccga catccagccg cgggcgatct cctcgacgca
      481 cagggcgtac gtcaggagcg actcgccgag gccgccgaac tcctccggga tcatcaggcc
      541 gaacaggccc agttccttga ggccgtcgac gatctgctgc gggtactcgt cgcggtgttc
      601 cagctccgtg gcgaccggga tgatctcctt gtccacgaag tcgcggacgg tggagaggat
      661 ctcctgctgg acgtcggtca gaccagcggt ccgggcgagg cgcgccatcg atcagccttc
      721 ctggagttcc gggcggccgg gctgctcgcc gccgcgttcc ttgatgtacg tctcggtcgg
      781 caccatcacc ttgcggcgga agacgcacac gagcgtgccg tcctgcttgt agcccttggt
      841 ctcgacgtgg acgatcccgc ggtcgttctt cgacttcgac ggccacttgt cgagcacggt
      901 cgtctgaccg tagagcgtgt ccccgtggaa ggtcggcgcg acgtgcttga gggactcgat
      961 ctccaggttg gcgatggcct tgccggagat gtccggcacc gacatgccga gcaggagcga
     1021 gtagatgtag ttgcccacca cgacgttctt gccgaagtcg gtcgtcttct ccgcatagtt
     1081 cgtgtccatg tggagggggt ggtggttcat ggtgaggaga cagaacaggt ggtcgtcgta
     1141 ctccgtgacc gtctttcccg gccagtgctt gtacgtcgcc ccgacctcga actcctcgta
     1201 ggtgcgtccg aactgcatgg cgctcagccc tccgggatct cgaacttgcc ggtgcgccgc
     1261 atgccggcgg cgcgcccctt gccggagatg acgagcgcca tcttgcggct ggcctcgtcg
     1321 atcatctcgt cgccgagcat cgccgagccc ttcttgccgc ccgcctcgga cgtgtagtag
     1381 tcgtacgcgt ccaggatcag ctcggcgtgg tcgtagtcct cctgcgacgg cgagaagatc
     1441 tcgttggacg cctcgacctg gcccgggtgc agcacccact tgccgtcgaa gccgagggcc
     1501 gcggcgcgcc cggcgacctc gcggtagccg tcgacgttgc ggatctggag gtaggggccg
     1561 tcgatcgcct ggaggtcgtt ggcgcgggcg gccatcagga tcttcatgag gatgtagtgg
     1621 taggcgtccg ccgggtagcc gggcggctgc tcgcccacga ccagcgactt catgttgatc
     1681 gacgccatga agtcggccgg gccgaagatg atcgtctcga tgcgcgagga ggcctgcgcg
     1741 atctcgttga cgttgttgag gccctgggcg ttctcgatct gcgcctcgat gccgatgcgg
     1801 ccgacctcga agcccatcgt cttctcgatc tgggtcagca gcaggtccag cgcgacgatc
     1861 tgctgggcgt tctgcacctt cggcagcatg atgcagtcga ggttgggtcc ggcgccctcg
     1921 accaccgtca cgacgtcgcg gtacgtccac tcggtcgtcc agtcgttgac gcgcacgacc
     1981 ctcgtcttgc cggtccagtc gccctcgttg aggaacttga cgatggtgtg ccgcgcctcg
     2041 ggcttggcga gcggcgcgca cgcgtcctcg aggtcgagga agacctggtc ggccgggagg
     2101 ccctgcgcct tctccaggaa gcgggggttg ctcccgggga ccgcgagaca ggagcgtcgc
     2161 ggacgcagac ggttgacaga ggggaggggg gcggcggagc cgctcgccgg cagggcggcg
     2221 gtgggcgacg ggcgggcggt catgcgggga cctccagggg gtcgagcttg ttcgctttcc
     2281 ggatctcgtc gacgatgcgg ccgatgattc cggtgatgtc gaagtccttc ggggtgaaga
     2341 ccgcggccac gccggcggcc cggagcagtt cggcgtctcc attcgggatg atgccaccgg
     2401 cgatcaccgg gatgtctgtg gcaccggcca cacgcagccg ttcgaggacg tccggcacca
     2461 gttgggcgtg cgaaccggac aggatggaca ggccgacggc gtgcacgtcc tcctccagcg
     2521 cggcgtccac gatctgctcg ggcgtcagcc ggatgccctg gtagaccacc tcgaagccgg
     2581 cgtcacgcgc gcgtacggct atctgctccg cgccgttgga gtgaccgtcc aggccgggct
     2641 tgccgaccag gaagcgcagc ttgcccacgc ccatgtcctt cgcggtgacc tcgaccctgc
     2701 ggcggacgtc ggccatggcc gagccctcct ccgcgggcac cgccacgggc gccgaggaga
     2761 ccccggtcgg cgcgcggaac tcgccgaaca cctcgcgcag cgccccggcc cactcgccgg
     2821 tcgtgacccc ggcgcgggcg cactccaggg tggcctccat gaggttggcg gtgcccttgg
     2881 ccgcctcctt cagcttctcc agcgccttgc acgggcgcgg gtggttgaag ggcggctggt
     2941 agcgggtgtc ccgccaggtg ccgagggagg ccacgaccct ggcctccacc gccgggtcga
     3001 ccgtctggat ggccgtgtcg aggtccgcgg tcagcgggtt gggctcggtc gtctcgaaga
     3061 tgttgacgcc gatgatcttc tcctgcccgg actcgatccg ggccctgcgc tcggcgtgcg
     3121 aggagacgag ctgcgacttg aggtagccgg actcgacggc ggccatcgcg ccgcccatct
     3181 cctggatccg ctcgatctcc gcgagggact gctcgaccag ctcggcgacc ttcgcctcga
     3241 cgacgtgcga gccctcgaac aggtcctcgt actccagcag gtcgctctcg tgggccagga
     3301 cctgctggat gcgcaggctc cactgctggt cccagggccg gggcagaccc agtgcctcgt
     3361 tccaggcggg cagctggacg gcacgcgcgc gtgcgtcctt cgacagcgtc accgcgagca
     3421 tctccagcac gatccgctgg acgttgttct ccggctgcgc ctcggtcagg ccgagggagt
     3481 tgacctggac gccgtagcgg aagcggcgct gcttggcgtc ctcgatgccg tagcgctcgc
     3541 gggtgatcct gtcccagata cggccgaagg cgcgcatctt gcacatctcc tcgacgaagc
     3601 ggacgcccgc gttcacgaag aaggagatcc gcgcgacgac gtcgccgaac ttctcggccg
     3661 gcacctgtcc ggagtcgcgg acggcgtcca gcacggcgat cgccgtggac atcgcgtacg
     3721 cgatctcctg caccggcgtg gccccggcct cctgaaggtg gtagctgcag atgttgatcg
     3781 ggttccactt cgggatgtgc gagaccgtgt acgcgatcat gtccgtcgtc aggcggagcg
     3841 agggtcccgg cgggaacacg tgcgtgccgc gggacaggta ctccttgacg atgtcgttct
     3901 gggtcgtgcc ctggagccgg gtgacgtccg caccctgctc ctcggcgacg acctggtaga
     3961 gcgccagcag ccacatggcg gtggcgttga tcgtcatcga ggtgttcatc tgctccagag
     4021 ggatgtcctg gaacagcctg cgcatgtcac cgagatgggc caccggcacg ccgacccggc
     4081 cgacctcgcc gcgggcgagg acgtggtcgg agtcgtagcc ggtctgggtg ggcaggtcga
     4141 acgcgaccga cagacccgtc tggcccttgg cgaggttgcg ccggtacagc tcgttggacg
     4201 cctctgccgt ggagtgaccg gcgtacgtgc gcatgagcca cggccggtcc ttctgacgct
     4261 cagtcatcta tgaccccggg tgtctcagat gttgcggaag cggttgatgg cgtcgaggtg
     4321 cagggcgcgc ttctcctcgt cgcgcacgcc caggccctcc tcgggcgcca gcgcgaggac
     4381 gccgaccttg ccctggtgga ggttgcggtg cacgtcgtac gcggcctggc cggtctcctc
     4441 gagcgagtag accttcgaca gggtcgggtg gatcttgccc ttcgcgatca gccggttggc
     4501 ctcccaggcc tcgcggtagt tggcgaagtg cgagccgatg atccgcttca gggacatcca
     4561 caggtagcgg ttgtcgtact cgtgcatgta gcccgaggtc gaggcgcacg tggtgatggt
     4621 gccgcccttg cgggtgacgt acacggaggc gccgaaggtc tcgcggccgg ggtgctcgaa
     4681 gacgatgtcg atgtcctcgc cgccggtgag ttcgcggatg cgcttgccga agcgcttcca
     4741 ctccttgggg tcctgggtgt tctcgtcctt ccagaaccgg tagccctcgg cgttgcggtc
     4801 gatgatcgcc tcggcgccca tggcccggca gatgtccgcc ttctggggcg aggacacgac
     4861 gcagatgggg ttggcgccgc cggccagcgc gaactgggtg gcgtagctgc cgaggccgcc
     4921 gctggcgccc cagatcagga cgttgtcgcc ctgcttcatg ccggcgccgt tgcgggagac
     4981 cagctgccgg taggcggtgg agttgacgag cccgggggcc gccgcctcct cccacgacag
     5041 gtggtccggc ttgggcatca gctggttgga cttgaccagg gcgatctcgg cgaggccgcc
     5101 gaagttggtc tcgaagcccc agatgcgctg ctcggggtcg agcatcgtgt cgttgtggcc
     5161 gtccgaggac tccagctcga ccgacaggca gtgcgcgacg acctcgtcgc ccgggttcca
     5221 ggcgttgacg cccgggccgg tgcgcaggac gacgcccgcg aggtcggagc cgatgatgtg
     5281 gtacggcagg tcgtgccgct tgctgaggtc gctgagccgg ccgtagcgct ccaggaagga
     5341 gaaggtcgac accggctcga agatcgaggt ccagaccgag ttgtagttga ccgaggaggc
     5401 catgacggcc accagggcct cgcccggtcc gagctcggga agggggacgt cgtccaggtg
     5461 gatcgacttg cgcgggtcct tgtcgcggct ctccaggccc gcgaacatct ccgcctcgtc
     5521 cttgtgcacg gtgatcgcgc ggtacgactc ggggagcggc agggcggcga agtccgccga
     5581 cgtggagtcc ggtgactgga tcgcgtcgag aatggcctgt gtggtcacgg tgtcgcctcc
     5641 ggcgatgagc gccctgaggg cggggcgctg agggttacgt cggtgtgctg ctgagggtgg
     5701 tggtgaggtg ccgtcggttc ggcgggtgtg ctgttcggca gcgctttgtg gcgcgggagg
     5761 ttgcctgtga cgcaggcgtc cgggcgcgca aatcaggtgc ttgcggggac agccggcgta
     5821 cgcatggtct ctgcacgccg gccgcccgga caccttcaac gtatgacacc gcgtgtcacc
     5881 ccgcaaggca ctgagtgcca gaacttccac tcagatgaaa tctttacgta acacatgagc
     5941 gatgatcgat cgaacgggct ccggatttcg cgcgaaaagg tgccctgaca tgccaaaacg
     6001 gccaccccgt gggggtggcc gtcgtcacag cggaaggcgg gcggcgagcg gtgctcagcg
     6061 ctccttgagg gcctgctcga tggtgcgcat gacctcgtcg agcgaggcgt cggtccgggc
     6121 gaccgtcacc aggacctcgc cgtgcgccga gaccgccgcc ggagcctgcc ggggtgcgcc
     6181 ggcgccgctg cggcccgcgc cgatgcccgt cccgaaggtc ttgcgcacga tcgcgaaggc
     6241 gtggtccagc tggctctcca cgtcgccctg gccgtccgcc cgcagccagc gccgcaggac
     6301 gtggttgtgg gcggtgacca cggcggacgc ggcgacctcg gcgagcagcg ggtcgtcgtt
     6361 ggcgtcgtcg tcatgggcgt gctcgtcgaa gtgaccgagc aggtagcggg tgaagaggcg
     6421 ctcgtagcgg gccaccgagg cgatctccgc ctcgcgcagg gtgggcacct cgcgggtgag
     6481 gcggtagcgg gcgaccgaga tctccggccg ggccgcgtac atcttcatga cctccttgat
     6541 gccgcggcac acggtgtcga gcggatgctc gtgcgccggg gccgcgttga gcacggcctc
     6601 cgcccggatc agggtgtcgt cgtggtcggg gaagatcgcc tcttccttgg agcggaagtg
     6661 gcggaagaag gtgcggcggg cgaccccggc cgcggccgcg atctcgtcga cggtggtcgc
     6721 ctcgtacccc ttggtcgaga acagctccat cgccgccgcc gccagttctc ggcgcatctt
     6781 gagccgctgg gcggccgcgc ggcttcccgc ggcactctcc ggcgcgtcgg gcgtggctgg
     6841 tgtacgtgag gacctggcgg gctggggcat gacccgaacg tactgcatgt gcgcagctcg
     6901 gtgcgtctgt ccgcggtttc ccccgacccg ggcgggcggg ggcgcgccgg tcgggtcgag
     6961 cagcccgccc cagtcctctt ctcctcggaa ccagtcgccg ccgccgtcag cggcgggcat
     7021 attcgcggaa accgcggccg gtcttgcggc cgaggcagcc cgcggccacc aggtgctcca
     7081 gaagcggtgc cggagccagg ccggggtcgc ggaactcgcg gtgcaggacc ttctcgatgg
     7141 cgagcgagac atcgagcccg acgacgtcca gcagctcgaa ggggcccatc ggatagccgc
     7201 cgcccagctt catcgcagcg tcgatgtcgt ccagggtcgc gtagtgctcc tggaccatct
     7261 tgatcgcgtt gttgaggtag gggaagagca gcgcgttcac gatgaagccc gcccggtccc
     7321 cgcagtcgac cgcgtgcttc ttgatccggc cgcacacctc gcgcaccgtc gcgtggacgt
     7381 cgtcggccgt cagcaccgta cggacgacct cgaccagctt catggcgggt gccgggttga
     7441 agaagtgcat cccgatgacg tcctgcgggc gcgaggtggc gcgggcgcag gcgacgaccg
     7501 gcagcgagga ggtcgtcgtg gcgaggatcg cgccgggctt gcagaccttg tccagggccg
     7561 cgaacagctg ctgcttgatc tcgaggtcct cggcgacggc ctccagcgcc agatcgacgt
     7621 cggcgaaggc gtcgtaggag cccgcagggg tgatccggtc gaggatcagg gcggcggcct
     7681 cggcggtcag ccggcccttg tcgacggagc gggcgagcga cttgccgatc cgggccttgg
     7741 cggtctgcgc cttctcctcg ctgcgggcgg cgaggacgac gtcgtagccc gccttggcga
     7801 agacctcggc gatgccggag gccatggtgc ccgagccggc gacgccgacc gaggagacgg
     7861 cgcgggagcc ggtgccgccg gcggcaccgg acagaggcgt cagcgcgtcc gggacgaccg
     7921 tcgcgctgcc gggcgcctcg taggtgtaga agccgcggcc cgacttgcgg ccggtcagac
     7981 ccgcctcgct gagctgcttg aggaccggcg cgggggcgtg cagcctgtcg tgcgactcgg
     8041 cgtacatggc ctccagcacc gtacgggcgg tgtcgacgcc gatcaggtcg agcagggcga
     8101 gcggccccat cggcaggccg cagcccagcc gcatcgccgc gtcgatgtcc tcacgggagg
     8161 cgtaccgggc ctcgtacatc gcggcggcct ggttgaggta gccgaacagc aggccgtcgg
     8221 cgacgaaacc ggggcggtcg cccaccgcga ccggctcctt gccgaggtcg agggcgaggt
     8281 tggtgacggc cgtgacggcg gcgggcgccg tcagcaccga ggagacgacc tcgaccagct
     8341 tcatggccgg cgccgggttg aagaagtgca ggcccagcac ccgttccggg cgcgccgact
     8401 cggcggcgag gcgggtcacg gagagcgcgt tggtcccggt ggcgaggatg gtctcgggcc
     8461 gcaccagccc gtccagttcg cggaagatct gctgcttgat ctcgtacgac tccggaacca
     8521 cctcgatgac gaggtcggcg tcggccgccg tgcgcaggtc ggtggagacc cggacgcggg
     8581 ccagcacgtc cgcgcgctcc tgctcggtga gccggccgcg ctccacggcg cgggcggtgg
     8641 aggcctccag cgcggcgagg gaccgcgcgg cctgggcctc gctgatgtcg acaccgacca
     8701 cctcccggcc ggccttggcc aggacctcgg tgatgccggt gcccatggtg ccgaggccga
     8761 tgacggcgat cgaacggagc ggggacagag gggtgtcgga caggggagcg gccatcgcgg
     8821 gactccagga atgagtgacg actgggaacg cgcccggcgc gccgggggtc ttcgacagac
     8881 ctgggcgcac cgggggcgga gaagggtgcg ggtggtgccg ggctgcgagc gcacacgccc
     8941 ggttccgtcg ccgcgggcgc gcacacgccc ggaggacgaa cggaggattc cgaccggccc
     9001 tgtcccgtgg ccgggtcgta cagcggtaca cggagtaccg aaccgacttc actcgcggcg
     9061 actgcgtcac caggccaccg cgaggaggtg cagcgagtgg gtaactcgct cgtctgagct
     9121 taaccggtgg gtaacgagcg cgccagcccc tgttcctgtg acgtggtccg catccgcgcc
     9181 cgcccaggcc ctacgctcgg cccatggacg aagagttgcg atcactcacg gagcgcttac
     9241 ggcgcgaggc cggggcgacg gcggcgttcg agcgcctggc gcgcaccgag gacctcggcg
     9301 aactcgcggg cgtgctcacc gagtcggggc agccgctgtg ggcgcgcgag ctggccgcgt
     9361 tccggctggg gctggccggc gaccggcgcg cgttcgaggc gctcgtcctg ctcctcaacc
     9421 accgggaccc cccgcgctgc tccggcgccg catacgcgct ggcccggctc ggcgacccgc
     9481 gcacggcccg tgccgcggcc accctggcca cgaacgaact gcgggtcgcc tacgcgctgc
     9541 accccgtacg gctgctggtg gagctgcgcg cgcccgaatc ggtgcccgcc ctcatcacga
     9601 ccctgcgccg gcggctgcgg ccgcacgacc cctaccggcg ggtggccctc gcgtgcgtgg
     9661 agggcctggg gacgctgggc gacgaccggg ggcgtccggt gctggaggac gccctggcgc
     9721 atccggcgct cgccgaggcg gccgtccacg cgctcgcgcg gattccgggg cagcggtgag
     9781 ccggcgcccc acgcgccccg cggcacgaca ctgacgacaa aggcgccatt gacccgcgat
     9841 tcggaaggtg agtacgtgtc gctcgttagt tcgtgattcg aataccttca cgtggggaag
     9901 atcgccctcc gccgaactgc gaaggcttgg cgcgcccgtc gggctgccga agtgaccgcg
     9961 gacgaggccg aattggtccg gctatggagg gtgaccgaaa gtgaccagtg cgcaacttcc
    10021 cgacgagata tccgacctga gcgcacgtcg agatccggac atcacgttcg gggggttcct
    10081 ggaggagaag tggaccgagg tctgccgcgg cctcggagtg gaccagtggg agaccgagac
    10141 cgtcctgcgc gacctgcgcg aagtgatcca cccctggggc tcccgtcccg tcgggacgcg
    10201 ctgtgacccg ccctcgttcg tctcggcgga cggattcccc gccgaactct ccgtcagctg
    10261 gaagggcggc cgtcccgagg tccgcatcct gttcgagtcg ctcggcgacg accgcactcc
    10321 gctcggctgt caggaggcgg gccgggagct gacccgtcgg ctggccggga gccccggcac
    10381 cgacatctcg cgctacctcg gcatcgagga cctcttcctc acgtccgccc ccgaccgcta
    10441 ccgggcgacc ctgtggcact ccctggcctg gcggccgggc aagcgcccgc actacaaggt
    10501 ctacctcaac ccgcaggtgc acggcctcga ccacgcctac gacgtgatgg cgcaggccat
    10561 ggagcggctg ggcctggcgg acgcctggga gccggtgggc cggcgcgggg ccgaactcgc
    10621 gcggcgcggg cacgagctgg agctgatggc cctcgacctc gacgccggcg acgccccccg
    10681 ggtcaaggtc tactaccggc accggccgat gccgatggac gagctggaca ccgtggcgga
    10741 gctggcgcac cgctacgagc cggtccgggc ggcccgcgcg cgcggcgtca tctacgggcg
    10801 ggacggcggc acggtgagca acgagccgat gacctgcctg gcgttccgcg aggacacctc
    10861 gggtccgcag gaggccaacg tctatctgcg gctgccggac aacaccgcct ccgacgcgga
    10921 ggcggccgag cgcatcgccc gtctcatgga actggagggg atcgacccgc gtccgcacgc
    10981 cgagatcgtg cgacggctga cggcgggcag gcccgccggt gccggcgggt tgcaggagct
    11041 gtgcagctac cggacgatct cgccggagat gcccgcggac atcggggtgt acctgcgctt
    11101 cggcacctac ggcggtccgg tgctctgagc ggtccggcgc ccggagcggt ccggcgccgg
    11161 gagcggtccg gcgtgtggtg ggcgtcagcc caccaccgcg aacgcctcga tctccatcag
    11221 gaactccggg cggaccagcg cggcgacctg gacggccgag gcggcgggca gccggtcgtc
    11281 gggtatgtgg ccggcccggg ccgcgcggat cgccggcatg tgggccatgt ccgtgacgaa
    11341 ataggtcagt ttgacgacgt cgtcgaaggt cgcgccggcc gcggcgaggc agcggcgcag
    11401 gttctcgaag acctggcggg cctgggcccg cgggtcgccc gcgccgaccg gcctgccgtc
    11461 ctcgtcgagc gggagctggc cggcgacggc cacgaaacgg ccggtgccca tgacgacatg
    11521 ggagtactgg gtcgccgcgg cgactccgtc gggggcggtg atcctggtcg ttgcgctcat
    11581 gcgtccatgg tggaccacgg gtgtgacaac gcccccgacg ggcggtggcc gacggctcag
    11641 ccgcggaagc ccagcagccc gtgcagcacc gaaccgtgcg tgcgggacgc gaccttcgag
    11701 gtcgtcggta cgggatcggg ctgcgccgcg cacaccgcgt cgaccccggc ggtcccgcgc
    11761 ggcaccgtgc cgtccgtcag gtaggcggcc aggtgcttgt ccaggcaggg gttcccgctc
    11821 agcgtgatcc cgtggttctg gccgccctcc tcgacgacca ggctggagcc gcgcagcagc
    11881 gcgtggaccg tcgcaccgcc ctcgtagggg gtggccgcgt cctccgtcgc ctggaacagc
    11941 aggaccggcg gcagcgcgcc gttggtgatg tcgaccggcc ccaccgggcg ggtcggccag
    12001 aacgcgcacg gcgcgttgta ccaggcgttg ctccaggtca tgaacggcgc cttggcgtac
    12061 aacgaccagt tgtcggtgcg ccattcgtcc cagtcgcgcg gccaggaggc gtcacggcac
    12121 tgcaccgcgg tgtagacgct gtagccgttg tccccggcgg cgtccacggc ggccaggttc
    12181 ttgtacgccg cgatcagcgg gtcggcgttc ttgtcgttca cgtacgcggc gaacgcctcg
    12241 gccagccggg gccagtagcc gttgtagtag ccgccgggca ggaaggtgtc ctccagctcc
    12301 gaggcgccca cctgcccgcc ggccggcttc gcgccgacgg ccgcccgcat cgcgtaccac
    12361 tcggtctcca ccttctcggg atcggtgccg aggcggtagg tcttgtcgta cttggcgatc
    12421 caggccatca gggcccggtg ccggtcgttg aacgccaggt cctgcgtgag gttgtcctcg
    12481 taccagacgc ccgaggggtc gacgacggag tccaggacca ggcgccgtac ccggtgcggg
    12541 tagagcttgg cgtacaccgc gccgaggtag gtgccgtacg agtagccgaa gtagttcagc
    12601 tgccgggcgc cgagcgcggc ccggacggcg tccatgtcgc gcacggtgct cagcgtgtcg
    12661 atgtggggca gcacgtccgc gtacttcttc gcgcaggccg cggcgaagga cttcgcgcgg
    12721 gtgaggttcg cccgctcgac ggcctcggtg tccggtaccg agtccgggcg gacgggtgcg
    12781 aagtggccgg gctcgcagtc cagcgcgggc gtgctcctgc ccaccccgcg cgggtcgaag
    12841 ccgatgacgt cgtactgggc cgccacggcc ttcggcagcg ccgaggcgac gaacccggcg
    12901 aggctcaggc cctggccgcc cgggccgccg ggattgacga gcagcgggcc ctggaacgtc
    12961 ttggcggtgt gcggcacccg cgacagcgcg agggtgatgc gtctgccgtc cggccgggcg
    13021 tggtcgagcg gtacctccag ggaggcgcac tggagcttcg gccggccggt gatgccgcag
    13081 ctcttccagt cgagccgggc cgccggggcg gacggcgcgg gggcggactg cgcggggcgt
    13141 gaggggtccg cggcggcggg tacggccgtg accgtcccgg ccacgacggc ggcggcagcg
    13201 cacagcacgg ctgcgcgtgg gttcatggac tgctcccggg acgacgacga ggccgcggac
    13261 ggccggaccg cgcaggtcac ggcccttgcc gcatcgtccc gggaacagca ccggccggaa
    13321 cctgttccgg ccctgcgtga cccgttcggg ccgcgggatg cgctcgaacg cccctgtgag
    13381 cccctctaga tcagcgtgag ctgggtcggc cccgggccgg tcggttcctc caccggttcc
    13441 ggcggcggta cccggcgtgg catccccgcg cgcgtggggc cgatgccgta ctcctccgcc
    13501 agctcgtgca cctgccgggt gatccggcgc tggtaccact tcggggcgta ggcgccgtcc
    13561 gcgtagagcc gctcgtagcg gcgcaccagg taggggtggt gccgtgcgag ccaggccatg
    13621 aaccactcgc gggcgccggg gcgcagatgc agcgcgagcg gtgtgaccga ggtggcgccc
    13681 gaggcggcga tcgcccgcac ggtcgcgcgc agccggtccg gctggtcgcc gaggaagggg
    13741 atcaccgggg ccatcaggac cccgcagccg atgccgtggt cggtgagggt gcggacgacg
    13801 tccaggcgcc gttcgggagc cggggtgccg ggttccacgg tccgccacag ctcggtgtcg
    13861 atgaagccga cggacaccga gacgccgacg tcggtcacct cggcgcactg ccgcagcaga
    13921 tcgaggtcgc gcaggacgag cgtgcccttg gtcaggatcg agaaggggtt cgcccggtcg
    13981 cgcagggcgg tcaggatgcc cggcatcagc cggtagcggc cctcggcacg ctggtagcag
    14041 tcgacgttgg tgcccatcgc cacgtgctcc ccgtgccagc gggtcgaggc cagctgacgg
    14101 cgcagcagct cgggcgcgtt caccttgacg acgatctggg tgtcgaagcc ggtgccggtg
    14161 tccaggtcga ggtagctgtg ggtcttgcgg gcgaagcagt acacgcacgc gtgcgtgcag
    14221 ccccggtagg ggttcaccgt ccactcgaac ggcatccgtg aggcgcccgg cacccggttg
    14281 aggatcgagc gggcccggat ctcgtggaac gtgatgccgg cgaactcggg cgtgtcgaag
    14341 gtcctggtcg tgaccgcgtc cgcgccgaac agcgcggcgt ccgccggccg gtcgtggcgg
    14401 gtctccacgg tgaggttctc ccagcgcatg acgcctcctc ggtagcactg cccccacaat
    14461 agaacatctg ttcccatgat cgtgcgaagg actcttcggc agccgtttcc gatcgccccg
    14521 cgatcgcttc cggggtgctt ggggcacccc gatttgggcg gccgtggacc ggggtggttg
    14581 gcttgccccg aacttgagga accccgaaca accctgaacg acacggacct ggaggaaccc
    14641 catggcgcag gtcgaggcca ccaccgagcg ggtcgtcgcc gcggacccgg agaaggtgtt
    14701 cgacaccatc gccgactaca gcgacgcgcg cggaaaactg ctgcccgagc acttcagcga
    14761 gtacgaggtg cgcgagggcg gcgacggcga gggctccctc gtccactgga agctccaggc
    14821 caccagcaag cgcgtgcggg actgcctcct ggaggtcacc gagccgaccg acggcgaact
    14881 cgtcgagaag gaccgcaact cctccatggt caccgtttgg cgggtcaccc cggcgggcga
    14941 gggcaggtcc cgcgtcgtgg tcaccagcac ctggaacggc gcgggcggca tcggcggttt
    15001 cttcgagaag acgttcgcgc ccaagggcct caaccggatc tacgacctga tcctcgcgaa
    15061 cctcgccgcc gaggtcgaga agtagcccgg caggtcaacc cctttgcggt ccccgtgcgt
    15121 tgaccctttc accggttcgg gtggatctcc ctcgtgaccg ggatggcgcc gtaactcgtc
    15181 gcacttgctc acagttgtcg cattgagcgg caattgtgtg gcaggtgcga cgaggggagc
    15241 ggctcacatg gggggcatca cgccggtgcg ggacgagccg gtcacggcgg cccccgcgga
    15301 ggacccgccc gccgcgccgg acaccccgcg cacacccggc ccgcgcgggg tgcggctggt
    15361 cttcttctcg ctcgtgctcg cgctgctcct cgcggcgctg gagcagatga tcgtcgccac
    15421 cgccctgccg aggatcgtcg gcgaactgca cggcgcggac cggatgtcct gggcgatcac
    15481 cgcctacctc ctcaccgcca ccgtcggact gccggtgtac ggcaagctcg gcgacctcct
    15541 cggccgcaag ggcgtcttcc agttcgcgat cgccgtcttc gtcatcggct ccgcgctcgc
    15601 cggacgggcg gggaccatgg accagctgat cgccttccgc gccgtccagg gcatcggcgc
    15661 cggcgggctc atgatcggcg tgcaggcgat catcgcggac atcgtcccgc ccaggcggcg
    15721 cggccggttc atgggactcg tcggcgccgc gttcggcctg gcctcggtcg ccgggccgct
    15781 gctcggcggc tacttcaccg accacctctc ctggcgctgg tgcttctggt tcaacgtgcc
    15841 cctgggcctg atcaccctcg ccgtggtcgg cgtcgcgctg aaactgccga agccgacggc
    15901 gccgccccgc ttcgacgtgc tcggcgccct gctgctggcc gccgcctcga cctgcctggt
    15961 cctgctcacc agttggggcg gcaccgagca cgcctgggac tccggcgtcg tcctcggcct
    16021 cggcgcgggc gcggccgtcg ccaccgccct gttcgtggtc gtcgagcgta tcgtcgccga
    16081 acccctcatc cccccgcggc tgttcaagga ccccgtcttc aacgtcaccg ctctggtggg
    16141 tctggtgacc ggggtcgccc tgttcggcgc cgccggctat ctgccgacct tcctccagat
    16201 ggtcgacggc gccaccgcca ccgggtccgg gctgctgatg ctgcccctga tgggcggtgt
    16261 cgtcggcgcc tcggtgctgt ccggacagct ggtctcgcac accggccgct acaagctcta
    16321 cccggttctc ggcagcgccc tcgccgtcct cggcatggcg ctgctgtccc ggctcgacgc
    16381 cgacaccccc cggctgcgct acagcctctg gatggccgtc ctcggcgccg gcatcggtct
    16441 ggtgctgccc gtcctcgtcc tcgccgtgca gaactccgtg cgtcccgccg acctcggcgc
    16501 cgccaccagc gccaccacct acttccggca gatcggcggc agcatcggcg ccgcggtctt
    16561 cggcacgctc ttcgccggcc ggctcacgga cgccctgcgc accgggctgc cggcgcacgc
    16621 gacaggagcc ctccccgacc ccggatccct caccccgcag ctcgtccacg ccctgcctcc
    16681 ggcgctgcgc gacgcctacg tccgcgccta cgccgacgcg atgccgaggg tcttcctcta
    16741 cctcgtgccg gtgctggccg tcggcctgct catcgcctgc ttcctcaagg agagaccgct
    16801 ggtgtcccag aacgccgccg aggcggaacc cgcgcccggg aacaccccgc cgccccaggc
    16861 cctgccccac cgctcgggac gggggagggc catctcctcc cgctcgccgc acgcgtccgg
    16921 cctccccgtg cgcggcaccg tccggcaccc cgacggcacc gccgtgccca gcgcggcgct
    16981 caccctcgtc gacgggggcg gacagcaggt cggccggggc gccagcggcc cggacggacg
    17041 gtacgcgctg tccacccccg gctccggcgc gtacgtcctg atcgccgccg cgggcggcca
    17101 ccagccgcag gcggtctcgg tcaccgtggg cgaacgcccc gtcgaactgg acgtcgtcct
    17161 cggcggcgcc ggacggctgg ccggccaggt gacgacggcc gacggcgccc ccgtcccgga
    17221 ggccaccgtg accctcaccg acgtgcacgg cgaggtcgtc gccggcaccc gcagcggacg
    17281 cgacggcggc tacctcatca ccgaactggt cgccggggag tacaccctgg ccgccgcggc
    17341 tgccggacac cgcccggccg ccgtgccggt cagcgtccag gcctcccgcg agacccgcca
    17401 ggacgtcgag ctcgccggcg gcgccctgct gcgcggcacc gtccgcgccc ccggcggcag
    17461 gccggtcgag gacgcgcgcg tgacgctcct ggacgcggcg ggcaacgtcg tcgacaccct
    17521 caccaccggg cccgacggca cgttccgctt cgtcgacctg tcgtccggcg agtacaccgt
    17581 catcgccacc ggctatccgc cggtcgccac cgtcctgcgc atggcgggcg gcggacgcac
    17641 ggaacgcgat ctgcggctcg ggcacgagga ctgacctgcc gggaagggcg gcgtaccccg
    17701 gcgcgcccgg gtgaaaccaa ttccaggatt gccccacatc ccgacggaag tgcgccgtac
    17761 ggtggtgacg gcgcgacaga tcttgcacag ctctggggag agagggcctg ggccatggac
    17821 cgtggcaccg agagggacgc acctcccagc cgcggagccg acggcggcgc ggccgacggg
    17881 ccggccggcg ccggccgcgt cccgctggcc gtggtcgtgg tggaccgcga gggcctcgtc
    17941 tcgcactgga gcaccggcgc acgccggctc ttcggcgtcg ccaaggaaga ggcgatcggc
    18001 cggcccgcga tcgacctgct ccccgtctcc ggcgcgctcc ccgatcccga ggacgacctg
    18061 ccggacggcg gccacggggg atacgagggg tacgcggcct acgacggtct cggccccggt
    18121 ctcgactcct ccctcgaccg gggcctcggc tacccggccg ccggacgcgc ccggctgagc
    18181 gtgcccggcg ggagcgggag cgcggcccgc gtgcccgggg gccgcggcgg cagcgagcgc
    18241 gtcgacgtgc tgtggtgggc gtacccgctg gtcggcccgg gcacggagcg gctgctggtg
    18301 ctcgccgcgg acgcggccgc actgcggcgc gacgacccgg ccgacccgct cgccgtggaa
    18361 cgcatagccc ccgccttcgc cctgcacacc gacttccccg gcgccacgga actcgcccgc
    18421 cggctccccg agatcctgcc cagcatgagc gtcggcgaca gcgcccgcat cgtcggacag
    18481 gtcctcgaac tcggctatcc ggtactggag ttcagtcaga acgaccggat ccccgtgacc
    18541 cccgactggg gggtggccag acgcgtcgag cgcagggcgc gccgtgagcg ggccgcgcgt
    18601 gcggccgccg agggcgccgt cgtgccccag gaccccgacg acgagggcga ggacctggag
    18661 tacgtcgccg tccgcgagcg gctggagttc ctcaacgagg tcagcgggaa gatcggcacc
    18721 accctggacc tgtcccgcac catcgaggag gtcagcaggg ccgtcgtccc ccgcttcacc
    18781 gacgtcgccg gcacctatct gcgcgaacag gtcgtcgccg gtgagggatt ccccgacggg
    18841 gtgccggaca cgaccaccct ctggcaccgc gtcgcggtcg agcacaccga cgagccgggc
    18901 cgctgggacg acgtcgtgcc cgtcggcgag gcgatgccgt tccccgcgca caccccgttc
    18961 ttccagtgca tgacgaccgg cctgcccgtc ctcgtgccgc gcatcggcga ggagctgggc
    19021 cacgccatcg cctcgcagtt cgagaagcgg gacatccggc ccctgatcac cggccgttcc
    19081 atgctcgtcg tcccgctgaa ggcccgtgac gtcgtcctgg gcttcatgat cctgctgcgc
    19141 caccccgaac gcgccccctt cgacgacatg gaccgggtca ccggcgccga actggccgcc
    19201 cgcgcgggcc tggtgctcga caacgcgcgg atgtacaccc accaggagag cgtcgccgag
    19261 accctccagg acagcatgct gccgcacatc ccgccgcgca tggcgggctg cgacatcacc
    19321 acccgctacc tgcccggcac cctgctcggg cgggtcggcg gcgactggtt cgactccgtg
    19381 aaactgccgg gtgcgcgcac cgctctcgtc gtcggcgacg tcatgggcca cggcctcaac
    19441 tccgccgcca tgatggggca gttgaggacg gccgtgcaga ccatggccgc cctcgacctg
    19501 ccgcccgccc aactcctgcg caatctcgac gacctggccc agcgactggg cgacacctac
    19561 ctcgcgacct gcctgtacgc cgtctacgac ccgatcgggg gcgagctgca cctcgccaac
    19621 gcgggccaca tcccgcccgt gctggtgcgc gccgccgacg gccgcagcga actcctggag
    19681 ctgcccaccg gcgcgcccat cggcgtgggc ggggtgccct tcgaggcggt acgcgtgcgg
    19741 gtgcggccgg gcgaccggct ggtgatgtgc accgacggtc tggtggaggt gcgcggcgag
    19801 gacatcggag tggggctcgc gaccctgtgc gagtcggccg cccacccggc cgcctccatg
    19861 gacgacgcct gcgacaccgt catccgggcc ctcaacaccc gcggcggccg caaggacgac
    19921 gtggccctgc tcctcgcccg gctcaacggc atcgccccgg acgacgtcgc cgaacggcgc
    19981 ttcccccgcg ccccctcgca ggtgggcccc gcccgtgcgg tggtccgtga acagctgcac
    20041 gtctggggcc tggacgagct cgccgacgcc gcagaactca tggtgagcga actcgtcacc
    20101 aacgccgtgc ggcactcccg ccaaaacccg gtcgccctgc gtctcgtgcg cggcgacacc
    20161 ctgctgtgcg aggtcgagga cgacgaccac gagctgccca ccctgctgag cgccgggccc
    20221 ggcgacgaac gggggcgggg actgcgggtg gtgagcgcgc tggcccgcga gtggggagcc
    20281 agccgtaccg ccgcgggcaa gtccgtgtgg ttcgaactgg cgctgccgca ccgctgagcc
    20341 ccggccggcc gagggcgcgc gcaggcgcga gaggcgcgca cggagcgcgg acacggtgtg
    20401 aaggaacgcg cggcccgctt gtcgcgccgc cccgggagcg atagaccgta ctcgcccgtc
    20461 acccacggcg gttcggtccg gcgaccaggg ggttgtgcat gagcgtgacg agtcggtacc
    20521 gcgaggcctg ggagggcttc tggcgcgagg ccccgcggga accgggcggg gtgttctggg
    20581 acgccgaccc gaaggtcacc gcggccctcc acctggccct gttcgaaccc catctcgccg
    20641 acccggggct gacgttgctg gacctcggct gcggcaacgg cacccagacc cggtacttcg
    20701 ccgaccgctt cccccgtgtg gtcggcgccg acctgtccgc cgcggccctc gatcacgccc
    20761 gccgcgccga ccccgcggga caggcggcct accggctgct cgacgcggcc gaccagggcg
    20821 cggccgaggc actgcacgcc gaactcggcg acgccaacgt gtacatgagg ggggtgctgc
    20881 accagtgcga gcccgcggac cggcagccgc tggcggacgc cctcgcggcc ctggtggggg
    20941 agcgcggccg ggtcttcctc gtcgaactct cgcaggccgc ccgcccggtg ctcggcgcgc
    21001 tggcgcaggg cccggccggt ccgccgccga agctcgcacc gatcctgcgc cacggcatag
    21061 cccccggcga ggtcgccgac gaggcggtgc ccgcccatct gcgcgccgcg ggcctcacgg
    21121 tgctggcc
//
