LOCUS       NZ_BMSI01000006        27542 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence06, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000006
VERSION     NZ_BMSI01000006.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 438523)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 410981
            Orig. end                         :: 438523
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27542
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="lanthipeptide-class-i"
                     /product="lanthipeptide-class-ii"
                     /region_number="4"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..27542
                     /SMILES="NCC(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="chemical_hybrid"
                     /product="NRPS"
                     /product="lanthipeptide-class-i"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /protoclusters="2"
                     /protoclusters="3"
                     /tool="antismash"
     protocluster    1..27542
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20000:23192](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..23192
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            436..1815
                     /locus_tag="IE189_RS18110"
                     /old_locus_tag="GCM10010496_37040"
     CDS             436..1815
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125817.1"
                     /locus_tag="IE189_RS18110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37040"
                     /product="SWF or SNF family helicase"
                     /protein_id="WP_189922799.1"
                     /transl_table=11
                     /translation="MNGYDNGEERTFAALPPARGGAFARTWWGRAWLTALEDGALDAEQ
                     VRTGRRLARAGAVGAVSVRPGRVTAVVRDTDLVQHRADVLLDRLSDARWDRLLGLAAER
                     AGHVAALLDREVPPELVEDAGTAGIDLLPGLGELEAECGCGAWDHCRHTAAVCYQVARL
                     LDQDPFVLLLLRGRTERRLMDDLQARGTTTPPGADAPPGGGSGDGEGAEGSGNREGVDA
                     AEAYAVGDILPPLPTAPDLPAGPGVPPSLDTDAPPPPGVEPAALETLAALTAVAARTLL
                     AEALHGGAGGQEPTARSTVAQDAVRLAAGMPEGATGAGPSADALTDRLARGSGRDRDEL
                     AAAVLAWRQGAADALSVCEEEWSVEGETLARARAALDSAWEEDERPHLHARANRWTVVG
                     AACQLRLGRDGRWWPYREEGGRWWPAGEAGHDPATVLAVAMAMAMARPDGEEGLSRRPV
                     L"
     gene            1948..3291
                     /locus_tag="IE189_RS18115"
                     /old_locus_tag="GCM10010496_37050"
     CDS             1948..3291
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069327.1"
                     /locus_tag="IE189_RS18115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37050"
                     /product="esterase-like activity of phytase family protein"
                     /protein_id="WP_189922801.1"
                     /transl_table=11
                     /translation="MSPHATGRRRVHRSVAAGVPLAVLAALVTAGPAAAGTPARDAHVT
                     RTAALSDIPLGTFSNGLLPGTVDDDRGVDLGGIGSDIYPAGRKGEFWTVTDRGPNGQIK
                     VGGTKRRTFPVPGFDPAIVRVRVSGATVKVVQAIPVTTSSGKPVTGLPNQAGRDEAPYS
                     YDARTPLSYDPNGLDTEGVVRAADGGFWLVDEYGPSLVHVSARGKVLARYVPQGLHLTG
                     TDYPVVEALPAVLLHRKINRGFEGLAQLPNGDLVLAVQSPLSLPDTAAGEASRTVRLLR
                     FSPGRKAVTAEYAYRFDPVGVVDPGEDDTSELKISSVVAVGGDRLLVEERTDKAARLHA
                     VRLSRASDILGGRWDDAGTSPSLEQLDDPAASGVPVLAKRLVVDLGTVAGVPGKIEGVA
                     VVDHDTLALANDNDFGMTDGADAFDAQGRLVDSGIETKITYVRLPRGL"
     gene            complement(3405..3878)
                     /locus_tag="IE189_RS18120"
                     /old_locus_tag="GCM10010496_37060"
     CDS             complement(3405..3878)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988663.1"
                     /locus_tag="IE189_RS18120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37060"
                     /product="hypothetical protein"
                     /protein_id="WP_189922803.1"
                     /transl_table=11
                     /translation="MAMPPVPPQPPGPPGGTPPPGGFGSPPPGFGPADTAGGGHRPPPP
                     PGRGRGNLLFVVLALLVAAGVVLAVVLTRSDSDDSPGHEPGAVSSSGSAADPSFGLPSG
                     LPSGLPSELPSRLPSGLPSGLPSSLPSGLPSGLPSELPSDLESLLPSLTALLP"
     misc_feature    complement(4102..4118)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            complement(4140..5306)
                     /gene="xylA"
                     /locus_tag="IE189_RS18125"
                     /old_locus_tag="GCM10010496_37070"
     CDS             complement(4140..5306)
                     /EC_number="5.3.1.5"
                     /GO_function="GO:0009045 - xylose isomerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042732 - D-xylose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="xylA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118437.1"
                     /locus_tag="IE189_RS18125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37070"
                     /product="xylose isomerase"
                     /protein_id="WP_189922805.1"
                     /transl_table=11
                     /translation="MSYQPTPDDRFTFGLWTVGWQGRDPFGDATRRALDPVESVQRLAE
                     LGAYGVTFHDDDLIPFGSSDSEREEHIKRFRQALDTAGMTVPMATTNLFTHPVFKDGAF
                     TANDRDVRRYALRKTIRNIDLAVELGAQTYVAWGGREGAESGAAKDVRVALDRMKEAFD
                     LLGEYVTSQGYDLKFAIEPKPNEPRGDILLPTVGHALAFIERLERPELYGVNPEVGHEQ
                     MAGLNFPHGIAQALWAGKLFHIDLNGQSGIKYDQDLRFGAGDLRSAFWLVDLLESAGYA
                     GPKHFDFKPPRTEDLDGVWASAAGCMRNYLILKERAAAFRSDPEVQEALRASRLDELAQ
                     ATAADGLESLLADRTAFEEFDPEAAAARGMAFEHLDQLAMDHLLGARG"
     protocluster    5073..27542
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[15072:>27542]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      15073..>27542
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
     protocluster    5073..27542
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[15072:18228](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="3"
                     /tool="antismash"
     proto_core      complement(15073..18228)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="3"
     misc_feature    complement(5335..5351)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.12"
                     /tool="antismash"
     misc_feature    5352..5364
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     misc_feature    5356..5369
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.61"
                     /tool="antismash"
     gene            5435..6880
                     /gene="xylB"
                     /locus_tag="IE189_RS18130"
                     /old_locus_tag="GCM10010496_37080"
     CDS             5435..6880
                     /EC_number="2.7.1.17"
                     /GO_function="GO:0004856 - D-xylulokinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005997 - xylulose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="xylB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1210: glycerol kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118438.1"
                     /locus_tag="IE189_RS18130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37080"
                     /product="xylulokinase"
                     /protein_id="WP_189922807.1"
                     /transl_table=11
                     /translation="MSAAEGPLVVGVDTSTQSTKALVVDAATGEVVASGQASHTVSSGA
                     GRESDPRQWWDALREALHQCGDAAREAAAVSVGGQQHGLVTLDERGEPVRPALLWNDVR
                     SAPQARRLTEELGGAGFWAERTGSVPAASFTVTKWAWLAENEPQALRATKAVRLPHDYL
                     TERLTGEGTTDRGDVSGTGWWASATESYDAEILAHVGLDPALLPRVVRPGEVAGTVRDS
                     HDLPFAKGTLVAPGTGDNAAAALGLGLRPGTPVLSLGTSGTVYAVAKHRPTDPTGTVAG
                     FADAHGDWLPLACTLNCTLAVDRVAALLGLDREAVEPAAGLTLLPYLDGERTPNLPNAS
                     GLLHGLRHDTTAGQLLQAAYDGAVHSLLGALDLVLDEDADRSAPLLLIGGGARGKAWQQ
                     TVRRLSGRPVQVPEAKELVALGAAAQAAGLLTGEDPAAVARRWNTTRGPVLDAVERDES
                     TLARIAGVLSDAAPLLDRSTDIR"
     gene            6911..8119
                     /locus_tag="IE189_RS18135"
                     /old_locus_tag="GCM10010496_37090"
     CDS             6911..8119
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003977660.1"
                     /locus_tag="IE189_RS18135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37090"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_189922809.1"
                     /transl_table=11
                     /translation="MTAPLHEARQTGPGRSLPDTQQGMRRRNLARVMHAVRAEGPLSRA
                     AVASRIGLTRAAVSTLVDELIRTGLLEELGPERPGRVGRPGSALAVSGRGPSGIGAEIG
                     VDHLAVCAVDLRGEVRARAVRHGTNRGRSPGPVVEELTALVRRVVAEAEREGLWPAGLA
                     VAVPGLVARDARTVVRAPNLDWQDVDLGALLPGEFALTVDNEANFGGLAELWLGEDTPA
                     DFLHVSAEIGIGAALVVDGALLRGTRGFAGELGHVPVHPDGPECVCGGRGCLEQYAGEE
                     AVLRAAGLAPGEDRVGLLAGRAADGDPQVRRALREAGTALGIALTGAINLLDPEGVVLG
                     GALAGLAPWLLPSLETELSRRTAGPARPVSVSRLGPEGPLLGAAHSVVRAVLDDPSMVA
                     ERA"
     gene            <8286..8525
                     /locus_tag="IE189_RS18140"
                     /old_locus_tag="GCM10010496_37100"
                     /pseudo=""
     CDS             <8286..8525
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009187371.1"
                     /locus_tag="IE189_RS18140"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37100"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /pseudo=""
                     /transl_table=11
                     /translation="FVDRPAYFTDALYESSARLTASVCDRYGIPKDRTRVIGHYEVPGS
                     DHRDPGPHWEWSRYLRLVDRTWREPDGRGAPASG"
     misc_feature    8562..8574
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            8657..9925
                     /locus_tag="IE189_RS18145"
                     /old_locus_tag="GCM10010496_37110"
     CDS             8657..9925
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125810.1"
                     /locus_tag="IE189_RS18145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37110"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_189922869.1"
                     /transl_table=11
                     /translation="MTDSWVALEPGADPAERVRVLRRAHEAFTEAGTVPRPVRPVVADS
                     WRRSARAGVGPDGTASVELTDGDLGAYRAEHPLARVMPLFRELMGTFAADGEHLLAVCD
                     AHGRLLWVEGHAATRRQADRMNFVPGARWAESAVGTNAPGTAVALDRPVQVFAAEHFIR
                     RVQPWTCAAAPVHDPRTGRVLGAVDITGGNGLAHPHSLGFVQAVARAAEAHLALLAPEP
                     PAADTPRLTVLGRDEARLVTGGREIRLSRRHSEILILLAGRPEGMTGDELLCALYEDES
                     VTPVTLRAELARLRGVLGPGLLASRPYRLTAAIESDVAVVERRLAAGAVTAAVTAYTGP
                     PLPTSRAPAVVRLGKRLADGLRAALIACGDPDLLADWAHAPWGEDDLEVWQALAAVRPT
                     AAIRARLASLRSELTAPAGWPRP"
     gene            10063..11586
                     /locus_tag="IE189_RS18150"
                     /old_locus_tag="GCM10010496_37120"
     CDS             10063..11586
                     /EC_number="1.2.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056340.1"
                     /locus_tag="IE189_RS18150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37120"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_189922811.1"
                     /sec_met_domain="Aldedh (E-value: 1.3e-164, bitscore:
                     542.6, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRYAAPGTEGAIVSYQARYDHFIGGAYVPPARGRYFDNPSPVNG
                     EAFTEVARGTAEDVERALDAAHAAAPGWGRTSATERSDILLKIADRMEAHLEALAVAES
                     WENGKPVRETLAADIPLAIDHFRYFAGAVRAQEGSLSEVDDDTVAYHFHEPLGVVAQII
                     PWNFPILMATWKLAPALAAGNTVVLKPAEQTPVSIHYWMSLIADLLPPGVINIVNGFGE
                     EAGKPLASSPRVAKIAFTGETSTGRLIMQYASQNLKPVTLELGGKSPNIFFDDVWEKDD
                     DLRDKALEGFTMFALNQGEVCTCPSRGLIQRGNYGDFLQAAVARTELIKPGHPLDTDTM
                     IGAQASGDQLAKILSYIDIGRKEGAKILTGGERAEYEGDLKGGYYVQPTIFEGDNRMRI
                     FQEEIFGPVVSVASFGDFDDAIKIANDTSYGLGAGVWTRDINTAYRAGRAIQAGRVWTN
                     CYHAYPAHAAFGGYKQSGIGRETHKMMLEHYQQTKNLLVSYSPKKLGFF"
     gene            complement(11762..14668)
                     /locus_tag="IE189_RS18155"
                     /old_locus_tag="GCM10010496_37130"
     CDS             complement(11762..14668)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827428.1"
                     /locus_tag="IE189_RS18155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37130"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_189922813.1"
                     /transl_table=11
                     /translation="MRLRAAHLIGREAEVTELGESLRDLNRSRGGTAFLVGEGGIGKSR
                     LVAELIGSALDAGVRVLKGRSSTIGPMVPLRPLTEALMPLSRGGVTPDEASLGPYRPVL
                     GRLIPGWSTGSPDQGSTVVLAEAVLRVLAHAGRESGCLLVLEDLHDADTETLAVVEYLV
                     DNLEHQPLMLAATIRSDPGEALSLAESAGRRRSATVFRLAPLDADGVGRMIASCLETDP
                     GRLPAEVLVQMWQDSAGIPFLVEELLQGAVAGGSLVREGAAWRVVGDLRRNMPRALLEG
                     AIHRIDQLGPQGRTVLSAAAVLGRRFPLSVLQSMTGVDDRSLLSHLHASVAARLVAADE
                     PAPDWYAFQHPLTAEALLAQLTPAARVALSEQAANAIETLNPGLPGDWCPLAATLRADA
                     GDPVRGGRLFAEAGRRALADGAVGSAVALLDRAERLLAEGGDSVARAEALEALLPALAE
                     TGELTRALSLTGTLRELVGAGLGAARLAALHTRLAHVAYMAGRWADGNSQIERARALLA
                     TAPDEAHTALTDVVEAYLCLDTPGQDRTQRAERLARAALGTAEREGLPLVACQAGELLA
                     VVARERDLSEASTYLEQAMSTAERHSLPLQRMYALTRLGGIRWLDDGSTATLEEARTEA
                     RRLGAVTVVYGIDGILTLHDVLRGRFTEARALGDETLTMAARLKLTSVARYLLMARSVL
                     AAHQGDRTAMEEALADFGRWGGRGSLEEPLALGLAQVFCALLEENRDQAAGVMADLKAL
                     EAENPTTFHLSGRHGLALLLDLLDGRADRAHLDRLTASAAGRMRWNRYFLLLAEAVLLG
                     REGRPEAAGQAALLAETTGAPYPTARHLGQRLIAEEAHALSWGEPERWLREAEHHFRET
                     SATAVVGACRTLLRAIGAPVRQHRTGSDRIPPELRMKGMTVREYEIFRLLADRPSNKDI
                     AVRLYISPRTVEKHVASLIAKTGLPNRSQLCALAAEQS"
     misc_feature    complement(14603..14605)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14739..14945)
                     /locus_tag="IE189_RS18160"
                     /old_locus_tag="GCM10010496_37140"
     CDS             complement(14739..14945)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004991555.1"
                     /locus_tag="IE189_RS18160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37140"
                     /product="hypothetical protein"
                     /protein_id="WP_189922815.1"
                     /transl_table=11
                     /translation="MSSFPQNGTVHDEATGASATVTDPAGEIRLVRWNGACARTRALAG
                     MTLGSGVVVGLGSATITTVSVPA"
     gene            complement(15073..18228)
                     /gene="lanM"
                     /locus_tag="IE189_RS18165"
                     /old_locus_tag="GCM10010496_37150"
     CDS             complement(15073..18228)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="IE189_RS18165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37150"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_189922817.1"
                     /sec_met_domain="DUF4135 (E-value: 5.2e-94, bitscore:
                     310.0, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.4e-25, bitscore:
                     83.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPTDTARPATEATPSWWAPAATLRERLSAPHPPAPAQATPAARL
                     RTRSPVESACESVRSARLGADTELVAALAAEPPARLAGRLAKPQWAVFVEGALAAAPET
                     PAEVRGAAVTAPADPADGAVVFGPVLRPLVTAAVAELAEQAGADGADPGETAVFAGDYA
                     DWLVRRLTRTAARTLVVELAAARTAGDLSGSTSAARFADFAARAGTRAGLARLFAGYPV
                     LARLLALTCRRTARSGAELLARLATDRQKLADELFGGRDPGPLVGVELGLGDLHQQGRS
                     VAVLRFAAGSAVYKPRPVDQHALLDRMAGWLDAKAPGLGLRTPRWVAGDGYGWLEYIDH
                     RTCRSLAEIDRFHRRQGVLIALAYTLEGVDLHYENVLAHGDQPVLVDVETLLHPVLREG
                     GTTRPDPAAGAHASSVHRTCLLPQLMVGELGAVDVSALGGAPGGESPDTRMVWEDAGTD
                     EMRMVRRPAPFTGALNRPYSAAAGPGSADRVAAVLAGFRTGYDAVVRHRDELSTPAGPL
                     GAGGDAVGRLVVRPTMLYATLLEEATHPQVLRDGLDRDAMFAVLWADSDGDPARQALIE
                     YEIADLWDGDVPVFFHRPGSTEVFAADGSPVSGVLDTSGLASSRAKLAAMSTVDRRAQE
                     WIISATLASAEPCAAGRRHRVSRRASPAPAVLPEPSALLAAASGIADEIAGRAVGGHGR
                     ANWVGLEAVDDRWTVLPMGAGLAQGYSGVALFLAQLGALTGSARHTELARAALAPVPEL
                     VAAMAADPALSRAVGPGGFEGLGGVCYALARVATLVDDDLAGCLPTALDALALAALGDD
                     TPPGVSAGLAGALAALLAVYRERGLPQAADLADRIAERLLGLAPAGRPGDGAPESFGFA
                     FGEAGIGWALARHARFAGGPLGARTEAAGRTRLTTALAAADRLDAGWCRGTAGVVLAAA
                     DAGLCPQSANGPARDASRRLIEHPPVADLSLCHGELGIAEAVAALAGCGHAEARSSLTG
                     RIGLVLGLLHAWGPSCGTPGRVPTPGLLTGLSGIGYALLRLGFADTVPSVLLLGPAQGG
                     GRD"
     gene            18576..19199
                     /locus_tag="IE189_RS18170"
                     /old_locus_tag="GCM10010496_37170"
     CDS             18576..19199
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015580244.1"
                     /locus_tag="IE189_RS18170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37170"
                     /product="response regulator transcription factor"
                     /protein_id="WP_189922819.1"
                     /transl_table=11
                     /translation="MGNPLSLCVVALDPLLEAGAVSALSGNPDIALVRPEEKADVAVVI
                     FDRVDREELDLVAATGGGPHRPAVIVIASHMSAAEAADAVNAGARGLLRRHEVDADRLA
                     RTVRTVAGGDCTVPPDLIDGLLDQSTETDAYPGVRGRGPDWGLDERERAVLRMVADGRE
                     TDEIAKELCYSPRTVTTVVRDITQRFRLRNRAHAVAYALRTGLL"
     gene            19196..19840
                     /locus_tag="IE189_RS18175"
                     /old_locus_tag="GCM10010496_37180"
     CDS             19196..19840
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="IE189_RS18175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37180"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_203833512.1"
                     /transl_table=11
                     /translation="MTGLVLEAAPVAGRDDGAPRVHLCPAGGAARDTVAAGLRRAGVEL
                     VAAGDRDGVVRVAAGRTPGAALEGRPEPGGGPLLLVADTFTAAGVRLAVRAGVTAMLQS
                     AEATPERLLTAVHAARYGDNRMPYGVLARLLDEAAGDEAERRHPVPDSPLTARQKTVLA
                     LVAEGHGNAAIARELSCSQHTVKNVMYDLMTRLQVRNRAHAVAYGVRTGLI"
     gene            20001..23192
                     /locus_tag="IE189_RS18180"
                     /old_locus_tag="GCM10010496_37190"
     CDS             20001..23192
                     /NRPS_PKS="Domain: Condensation_LCL (8-300). E-value:
                     1.1e-98. Score: 321.8. Matches aSDomain:
                     nrpspksdomains_IE189_RS18180_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (469-861). E-value: 5.6e-97.
                     Score: 316.8. Matches aSDomain:
                     nrpspksdomains_IE189_RS18180_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (969-1036). E-value: 5.6e-27. Score:
                     85.7. Matches aSDomain: nrpspksdomains_IE189_RS18180_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487428.1"
                     /locus_tag="IE189_RS18180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37190"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_189922821.1"
                     /sec_met_domain="Condensation (E-value: 3.3e-66, bitscore:
                     217.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 5.3e-107, bitscore:
                     352.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.4e-17, bitscore:
                     57.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRCDGRTTSFSQQRLWFLDQLRPGTADHLLPLALRLRGDLDTEA
                     LAAALADVVDRHEVLRTRYAAADGEPVAHVVPRVEVLLDRVDAPAAGAAGIAAVLDRAL
                     RRPVDLSTAPPLRATLARLAPDDHLLVVVVHHIAFDFSSWNVLTRDLAAAYRGRTTGVR
                     HGLPELPVQYSDLAALQRERSAGPRLARGLDHWRSRLAGLPPLDLPTDRPRPAEFDGAA
                     AVARFTLPADLVALTDRLARSRRATRFMVLLAAFQAQLGRYSGQSDFAVGTPVAGRGHP
                     AARDLIGPFVNTVVLRADLSGRPGFGELVDRVRHTFLADLTHADTPFERVVGELAPSRD
                     LSRNPLFQVSFLTLDSQAEPPDLPGLSVEVVPTPVAGTPFDLALDLLGRPDGSLGLRLG
                     YATALFTPETAARITEDYVRLLHELLAAPDKPLAGVTSVLEPLPGGERRRRLALGLGSA
                     RAVPPQTVTDLFEQQSRRTPHAIAVSSGDGELSYAGLDRRADELAHRLRGLGVGRGTRV
                     GVLLERGTGLLVALLGVLKADAAYVPLDPLHPARRIGHLIEDTRAAVVVTTGPLAGRVA
                     GTEARTLLLDGDPPPAGPADRRERTTGPHDLAYVFHTSGSTGTPKGVQIPHHALTNFLL
                     AMAARLETGPEATVLGVTTASFDPSMLELCLPLLTGARLVLADSEQARDPERLIRLIGE
                     ARPDLMQATPSMLRTLVDTGWTPGPGLTVLSGGEKLHTDLAAALAADGAPVLDLYGPTE
                     ATIWTSVARHGADGRVERWAAVDNTTVRVLDDRLEPVAEGVTGHVCIGGDGLAWGYRGR
                     PAQTAGVFLPDPHATAPGGRLYFTGDLGRIRPDGSLEILGRSDHQVKIRGHRIEPGEIE
                     AALLALDGVRAAVVHPTPDADGGQQLTAYLVADDSGNPPTPDALRAELLDSLPHHLVPA
                     AFVLLDAIPTAVSGKVDRHALPVPAPQAAGPAAAPRTPRERSVARVWEEVLGATGIGAH
                     DDFFLLGGHSLLATRVSVRLRAALGVDVPVRALFDHPTVAALATALDGYPPLAPDGPLP
                     RLTARPRGARTTAGR"
     aSDomain        20025..20900
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS18180_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.10E-98"
                     /label="IE189_RS18180_Condensation_LCL.1"
                     /locus_tag="IE189_RS18180"
                     /protein_end="300"
                     /protein_start="8"
                     /score="321.8"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIAFDF"
                     /tool="antismash"
                     /translation="TSFSQQRLWFLDQLRPGTADHLLPLALRLRGDLDTEALAAALADV
                     VDRHEVLRTRYAAADGEPVAHVVPRVEVLLDRVDAPAAGAAGIAAVLDRALRRPVDLST
                     APPLRATLARLAPDDHLLVVVVHHIAFDFSSWNVLTRDLAAAYRGRTTGVRHGLPELPV
                     QYSDLAALQRERSAGPRLARGLDHWRSRLAGLPPLDLPTDRPRPAEFDGAAAVARFTLP
                     ADLVALTDRLARSRRATRFMVLLAAFQAQLGRYSGQSDFAVGTPVAGRGHPAARDLIGP
                     FVNTVVLRADL"
     aSModule        20025..23108
                     /complete
                     /domains="nrpspksdomains_IE189_RS18180_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE189_RS18180_AMP-binding.1"
                     /domains="nrpspksdomains_IE189_RS18180_PCP.1"
                     /locus_tags="IE189_RS18180"
                     /monomer_pairings="Gly -> Gly"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       20091..20192
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS18180_0001"
                     /evalue="1.00E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE189_RS18180"
                     /protein_end="64"
                     /protein_start="30"
                     /score="50.0"
                     /tool="antismash"
                     /translation="LPLALRLRGDLDTEALAAALADVVDRHEVLRTRY"
     CDS_motif       20400..20465
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS18180_0002"
                     /evalue="1.70E-07"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE189_RS18180"
                     /protein_end="155"
                     /protein_start="133"
                     /score="23.8"
                     /tool="antismash"
                     /translation="VHHIAFDFSSWNVLTRDLAAAY"
     CDS_motif       20802..20891
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS18180_0003"
                     /evalue="1.30E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE189_RS18180"
                     /protein_end="297"
                     /protein_start="267"
                     /score="46.5"
                     /tool="antismash"
                     /translation="DFAVGTPVAGRGHPAARDLIGPFVNTVVLR"
     CDS_motif       20940..21053
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS18180_0004"
                     /evalue="8.20E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE189_RS18180"
                     /protein_end="351"
                     /protein_start="313"
                     /score="50.3"
                     /tool="antismash"
                     /translation="RHTFLADLTHADTPFERVVGELAPSRDLSRNPLFQVSF"
     aSDomain        21408..22583
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS18180_AMP-binding.1"
                     /evalue="5.60E-97"
                     /label="IE189_RS18180_AMP-binding.1"
                     /locus_tag="IE189_RS18180"
                     /protein_end="861"
                     /protein_start="469"
                     /score="316.8"
                     /specificity="substrate consensus: Gly"
                     /tool="antismash"
                     /translation="FEQQSRRTPHAIAVSSGDGELSYAGLDRRADELAHRLRGLGVGRG
                     TRVGVLLERGTGLLVALLGVLKADAAYVPLDPLHPARRIGHLIEDTRAAVVVTTGPLAG
                     RVAGTEARTLLLDGDPPPAGPADRRERTTGPHDLAYVFHTSGSTGTPKGVQIPHHALTN
                     FLLAMAARLETGPEATVLGVTTASFDPSMLELCLPLLTGARLVLADSEQARDPERLIRL
                     IGEARPDLMQATPSMLRTLVDTGWTPGPGLTVLSGGEKLHTDLAAALAADGAPVLDLYG
                     PTEATIWTSVARHGADGRVERWAAVDNTTVRVLDDRLEPVAEGVTGHVCIGGDGLAWGY
                     RGRPAQTAGVFLPDPHATAPGGRLYFTGDLGRIRPDGSLEILGRSDHQVKIR"
     CDS_motif       21594..21635
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS18180_0005"
                     /evalue="7.90E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IE189_RS18180"
                     /protein_end="545"
                     /protein_start="531"
                     /score="15.9"
                     /tool="antismash"
                     /translation="LGVLKADAAYVPLD"
     CDS_motif       21822..21881
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS18180_0006"
                     /evalue="1.80E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="IE189_RS18180"
                     /protein_end="627"
                     /protein_start="607"
                     /score="26.6"
                     /tool="antismash"
                     /translation="AYVFHTSGSTGTPKGVQIPH"
     CDS_motif       22374..22460
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS18180_0007"
                     /evalue="5.60E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="IE189_RS18180"
                     /protein_end="820"
                     /protein_start="791"
                     /score="34.7"
                     /tool="antismash"
                     /translation="EGVTGHVCIGGDGLAWGYRGRPAQTAGVF"
     CDS_motif       22551..22613
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS18180_0008"
                     /evalue="3.50E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="IE189_RS18180"
                     /protein_end="871"
                     /protein_start="850"
                     /score="38.2"
                     /tool="antismash"
                     /translation="LGRSDHQVKIRGHRIEPGEIE"
     aSDomain        22908..23108
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS18180_PCP.1"
                     /evalue="5.60E-27"
                     /label="IE189_RS18180_PCP.1"
                     /locus_tag="IE189_RS18180"
                     /protein_end="1036"
                     /protein_start="969"
                     /score="85.7"
                     /tool="antismash"
                     /translation="ERSVARVWEEVLGATGIGAHDDFFLLGGHSLLATRVSVRLRAALG
                     VDVPVRALFDHPTVAALATALD"
     gene            23223..24491
                     /locus_tag="IE189_RS18185"
                     /old_locus_tag="GCM10010496_37200"
     CDS             23223..24491
                     /NRPS_PKS="Domain: Aminotran_3 (29-362). E-value: 1.4e-70.
                     Score: 229.9. Matches aSDomain:
                     nrpspksdomains_IE189_RS18185_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381147.1"
                     /locus_tag="IE189_RS18185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37200"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_189922823.1"
                     /sec_met_domain="Aminotran_3 (E-value: 8.2e-74, bitscore:
                     243.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLATTDTSVFEKIESEVRMYCRTFPVVFERAKGALLHTDDGRP
                     FIDFFCGAGSLNYGHNHDAVKRRIIDYLADDGLMHGLDMHTVAKRDFLTRLTEVVLQPR
                     GLDFKVQFTGPTGTDAVEAALKLARRATGRTGLTAFTGAYHGMSRGSLEVTGSRRARRA
                     GTVAGGDVTFVPFEDGPLGPFDSIGLIERLWADPSSGTEPPAAVVVESVQMEGGVYPAS
                     REWLRRLREVTERHGVLLILDEIQTGCGRTGAFFGFEESGIVPDIVTVSKSLSGYGLPL
                     SLTLFRRELDLWQPGEHTGTFRGNQLAFVAATAACELWQQDDFLSGLQQGAERLARFRA
                     DAAALDPGLVVRGRGMVLGVDTAGAGGAERAERVQRHAFERGLIVERCGRYDEVLKVMP
                     PLTIEPGLLDDGLGILLDALQAN"
     aSDomain        23310..24308
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS18185_Aminotran_3.1"
                     /evalue="1.40E-70"
                     /label="IE189_RS18185_Aminotran_3.1"
                     /locus_tag="IE189_RS18185"
                     /protein_end="362"
                     /protein_start="29"
                     /score="229.9"
                     /tool="antismash"
                     /translation="FERAKGALLHTDDGRPFIDFFCGAGSLNYGHNHDAVKRRIIDYLA
                     DDGLMHGLDMHTVAKRDFLTRLTEVVLQPRGLDFKVQFTGPTGTDAVEAALKLARRATG
                     RTGLTAFTGAYHGMSRGSLEVTGSRRARRAGTVAGGDVTFVPFEDGPLGPFDSIGLIER
                     LWADPSSGTEPPAAVVVESVQMEGGVYPASREWLRRLREVTERHGVLLILDEIQTGCGR
                     TGAFFGFEESGIVPDIVTVSKSLSGYGLPLSLTLFRRELDLWQPGEHTGTFRGNQLAFV
                     AATAACELWQQDDFLSGLQQGAERLARFRADAAALDPGLVVRGRGMVLGVDT"
     gene            24521..25468
                     /locus_tag="IE189_RS18190"
                     /old_locus_tag="GCM10010496_37210"
     CDS             24521..25468
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1114: ornithine carbamoyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487430.1"
                     /locus_tag="IE189_RS18190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_37210"
                     /product="ornithine carbamoyltransferase"
                     /protein_id="WP_189922825.1"
                     /transl_table=11
                     /translation="MPRPDRHHLISVDDLTDRELRRLVHRGAQYAAGECEGARPLADAV
                     VGVLFRKTSTRTRTAFSAGALRLGARLITYGPGDLQENTGESSEDTGDVLSRMLDVLVA
                     RTAGSTEELRAYAAQQRMAVINAMSAAEHPTQALTDLTTMLGRFGRIEGLRVLYAGEGN
                     NTASALALALSRFRGTELHLRTPPGYGLDAAFLDRAAVHAKESGALVEERHNMADLPEV
                     DIVYTTRWQTTGTTKPDPDWRRVFAPFRVDAAVLAACPGAVFMHDLPAHRGDEVTGEVL
                     DGPASIAFQQAENKYHSARAVLEWCLGGIPAEPA"
     misc_feature    complement(24545..24558)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            25521..>27542
                     /locus_tag="IE189_RS18195"
     CDS             25521..>27542
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015580236.1"
                     /locus_tag="IE189_RS18195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_189922827.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.5e-49, bitscore:
                     160.5, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTIRMPGGGWRLWTHFALRGPGFPAAGVLRLAPEGLASAADKF
                     APGEVPAGADWQAFEEAFSAAAVRTARDLQEIAASAPFRAAVAWQNRTVLRTGIKPFLD
                     WTPSAEGRTSMPRQREELVAHYWQRFCVKNDTIGFFGPVGWGTFDPSRHDIEVHPGTGL
                     VAESRVYFSSWSMDALAKAIDRDPRVRAWTPPRQVPFVRVVDGAVRLPGRPPQPAPEPA
                     LTVLRLCDGRRTPAEITALAARELGRDLPAGEVTEALEWLVSRRLIGWKLDVPAGTYPE
                     RELRAMLERIGDPAVREPALAKLAVLETGRDRVQRAGADPEELTAALAALEAGFAEITE
                     VSAVREKGARTAPNRALVYADCRRSATATVGTAVLARLAPLELCLTAARWMTNRYAEAI
                     VARVHEAYQELRKLHEQVDLGSLWFACLPAPHPESLTDIERIQAELRERWARIIDAPAG
                     ARRVSLSSAAIADRVHEAFPDGGRGWSLSRYISPDLMIVAEDAAAVERGEFQLVIGELH
                     VAMNTLAQSLFVHQHPDREQLIDETTRDFPGPRLLPMLPKELPLKWSARSRQSLDRPED
                     HYVALADHSADPHRPRTVRSGEVRVEERDGGLAAVLPDGSVFDLLDVFCHALSNRVMDR
                     FTLRRDGDHSPRITIDSTVVARESWRFAGSALAFADDKS"
ORIGIN
        1 ggcacggctg ctggaacagc acctggcggc ccgcggcgtc cccacccggt tcctgcacgg
       61 cggggtcccg gtcgccgagc gggaggccat ggtcgcgcgt ttccaggccg gtgaggtccc
      121 ggtgttcctg ttgtccctca gggcggccgg caccggcctc aacctcacgc gcgcggagca
      181 cgtcgtgcac tacgaccgct ggtggaaccc ggccgtcgag gcacaggcca cggaccgggc
      241 gtaccgcatc ggccagaccc ggcccgttca ggtgcaccgg ctcatcgccg agggcaccgt
      301 ggaggaccgc atcgccgaca tgctgcgccg caagaaggat ctcgccgacg ccgttctcgc
      361 gggcggcgag gcggcgttca ccgaactgac ggacgccgaa ctggccgacc tggtggagct
      421 gagagagggc acgcgatgaa cgggtacgac aacggcgagg aacgcacctt cgccgccctg
      481 cctcccgcgc gcgggggcgc gttcgcgcgg acctggtggg ggcgcgcgtg gctgacggcc
      541 ctcgaggacg gcgcgctgga cgcggagcag gtgaggacgg gacggcggct cgcacgcgcg
      601 ggtgccgtgg gcgcggtgtc cgtccggccg ggacgcgtca ccgccgtcgt ccgggacacc
      661 gatctcgtgc agcaccgggc ggacgtgctg ctcgacaggc tctccgacgc ccggtgggac
      721 cggctcctcg gtctcgctgc ggaacgcgcg ggccacgtcg ccgcgctgct cgaccgggag
      781 gtgccgcccg agttggtcga ggacgccggg acggccggca tcgacctgct gccggggctc
      841 ggcgagctgg aggcggagtg cgggtgcggc gcctgggacc actgccggca cacggcggcg
      901 gtgtgctacc aggtggcgag actgctcgac caggacccgt tcgtcctgct gctccttcga
      961 ggacgcaccg aacgacgact gatggacgac ctccaggcac gcggcaccac caccccgccc
     1021 ggggcagacg cgccccccgg tgggggcagt ggggacggcg agggggccga ggggagcggg
     1081 aaccgcgagg gggtcgacgc ggcggaggcg tacgccgtcg gggacatcct gcccccgctg
     1141 cccacggcac ccgacctgcc ggcgggaccg ggggtgccgc cctcgctgga cacggacgcg
     1201 ccgcccccgc cgggagtcga accggcggca ctggagacgc tggccgcgct gacggccgtc
     1261 gcggcacgca ccctgctcgc ggaggcgctc cacggcggcg ccggagggca ggagccgacc
     1321 gcccggtcga cggtggccca ggacgccgta cgcctggcgg ccggaatgcc cgaaggggcg
     1381 acaggcgccg gtccgtcggc cgacgccctg acggaccggc tcgcccgggg atccgggcgc
     1441 gaccgggacg aactcgcggc cgccgtgctc gcctggcgcc agggagcggc ggacgccttg
     1501 tcggtgtgcg aggaggagtg gtccgtggag ggcgagacgc tcgcacgcgc gcgtgccgcg
     1561 ctggactccg cctgggagga ggacgaacgg ccccacctgc acgcgcgggc gaaccggtgg
     1621 acggtggtgg gcgcggcctg ccagctgcgg ctgggccggg acggccgatg gtggccctac
     1681 cgcgaggagg gtggccgctg gtggccggcc ggggaagccg gccacgaccc ggcgacggtc
     1741 ctggcggtgg cgatggcgat ggcgatggcg aggcccgacg gtgaggaagg gctttcccgg
     1801 cgcccggtcc tgtaggtgtc gcgcggggcg ccggtccgac gggcggccga cgccccgcgt
     1861 tcacccggag gtcttgcgcc gttcggtgcg tgcccgaact ctggccgctg tcacggaact
     1921 tgccgtgacc tctccacagg aggcccgatg tccccgcacg ccaccggccg gcgccgcgtc
     1981 caccgaagtg tcgcggcggg cgtaccgctc gccgtcctgg ccgcgctcgt caccgccggg
     2041 ccggccgccg cgggcacgcc ggcccgggac gcccacgtga cacggaccgc cgcgctctcc
     2101 gacatcccgc tcggcacgtt cagcaacgga ctgctgcccg gcacggtgga cgacgaccgg
     2161 ggcgtcgacc tcggcggcat cggcagcgac atctacccgg cgggccgcaa gggcgagttc
     2221 tggacggtca ccgaccgcgg gcccaacgga cagatcaagg tcggtggcac caagcgccgc
     2281 accttccccg tgcccggctt cgatccggcg atcgtacgcg tcagggtctc cggcgccacg
     2341 gtgaaggtgg tgcaggcgat tcccgtcacc acgtcgtcgg gcaagcccgt gacggggctg
     2401 ccgaaccagg cgggacgcga cgaggctccc tactcctacg acgcacggac gccgctgtcg
     2461 tacgacccga acgggctcga caccgagggc gtcgtacggg ccgcggacgg ggggttctgg
     2521 ctcgtcgacg agtacgggcc ctcgctggtc cacgtctccg cccgcgggaa ggtgctggcg
     2581 cggtacgtgc cccaggggct gcacctcacg ggcacggact acccggtggt ggaggcgctg
     2641 cccgcggtcc tgctgcaccg gaagatcaac cgcggcttcg agggcctggc ccaactcccg
     2701 aacggcgacc tggtcctggc ggtgcagagc ccgctgtcgc tgccggacac ggccgcggga
     2761 gaggcgtcga ggaccgtccg gctgctgcgc ttctcgcccg gcaggaaggc ggtcaccgcc
     2821 gagtacgcct accgcttcga cccggtcggt gtggtcgacc cgggcgagga cgacacctcc
     2881 gagctcaaga tctcctcggt ggtggccgtc ggcggcgacc gcctgctcgt ggaggaacgc
     2941 acggacaagg ccgccagact gcacgcggta cggctgagcc gggcgtcgga catcctgggc
     3001 ggccgctggg acgacgccgg gacgtcgccc tcgctggagc agttggacga ccccgccgcc
     3061 tcgggcgtcc cggtgctggc caagcggctg gtcgtcgacc tcgggacggt cgccggagtt
     3121 cccggcaaga tcgagggtgt cgcggtcgtg gaccacgaca ccctggctct cgccaacgac
     3181 aacgacttcg ggatgacgga cggcgccgac gccttcgacg cgcagggcag gctggtcgac
     3241 agcggcatcg agacgaagat cacttacgtg cggctgcccc gcggcctgta ggagagcccg
     3301 aacccggcac gcccgcaggg gccgtgcctc gcatgcgcgc gtggtccgac gcggtgtccg
     3361 cgtccacgcg cgcgtaccgt cgaggcgcag gcgcacacgt gccgctaagg aagcagcgcc
     3421 gtcagcgacg gcagcagcga ctccagatcg ctcggcaact ccgacggaag accgctcggc
     3481 agcccggacg gcaggctgct cggcagcccc gagggcagtc cgctgggcaa ccgcgagggc
     3541 agttcactcg gcaggccgct cggaagaccg ctcggcaggc cgaaggaggg atcggccgcg
     3601 gagccgctgc tgctgacggc gccgggctca tggcccgggg agtcgtcgct gtcggagcgc
     3661 gtcaggacga cggcgaggac gaccccggct gcgacgagca gcgcgaggac cacgaagagc
     3721 aggttcccgc gcccgcggcc cggcggtggg ggcggccggt ggccgcctcc cgccgtgtcg
     3781 gccggtccga agccgggcgg gggcgatccg aaaccgcccg gaggcggtgt gccgcccggt
     3841 ggtccgggcg gctggggcgg tacgggcggc atggccatac cgtccagcgt cccggcgaac
     3901 ggctcaggag gcgagcccca cagggaagtt gatacacgtc ggtggcgatc cgcgtcaggg
     3961 accgcatcat tccggatcgt tgcggatcgt tcatgcgcgt tccggatcgt tgcggatcgt
     4021 tccggcgcgg tcaggctgcg ttcggtgcgg gaagaccggg cgcaggcctg tcgtcgggcg
     4081 gccggcccgc gcgcgtgtgt gtgcacctga cctgtgcgca cacacgcgcg cgtgcgggct
     4141 cagccgcggg cacccagaag gtggtccatg gcgagctggt cgaggtgctc gaaggccatg
     4201 ccgcgggcgg cggccgcctc cgggtcgaac tcctcgaagg ccgtacggtc ggcgagcagg
     4261 ctctccagac cgtcggcggc ggtggcctgg gcgagctcgt cgaggcggga cgcgcgcagg
     4321 gcctcctgga cctccgggtc gctgcggaac gcggccgcac gctccttgag gatcaggtaa
     4381 ttgcgcatgc agcccgcggc ggaggcccac accccgtcga ggtcctcggt gcgcggcggc
     4441 ttgaagtcga agtgcttcgg gcccgcgtag ccggcgctct ccagcaggtc gaccagccag
     4501 aacgcggagc gcaggtcacc ggcaccgaag cgcaggtcct ggtcgtactt gatgccggac
     4561 tggccgttga ggtcgatgtg gaagagcttg cccgcccaca gcgcctgggc gatgccgtgc
     4621 gggaagttga gcccggccat ctgctcgtgg ccgacctcgg ggttgacgcc gtacagctcc
     4681 gggcgctcca ggcgctcgat gaaggccagc gcgtgaccga cggtggggag caggatgtcg
     4741 ccgcggggct cgttcggctt gggctcgatg gcgaacttca ggtcgtagcc ctgggaggtc
     4801 acgtactcgc cgagcaggtc gaaggcctcc ttcatgcggt cgagggccac ccgtacgtcc
     4861 ttggcggcac ccgactccgc accctcacgg ccgccccagg cgacgtaggt ctgcgcgccg
     4921 agctcgaccg ccaggtcgat gttgcggatc gtcttgcgca gggcgtaccg gcgcacgtca
     4981 cggtcgttcg ccgtgaaggc gccgtccttg aacacggggt gcgtgaagag gttcgtggtg
     5041 gccatcggca cggtcatgcc ggccgtgtcc agggcctggc ggaagcgctt gatgtgctcc
     5101 tcgcgctcgc tgtcggagga cccgaagggg atcaggtcgt cgtcgtggaa ggtcacaccg
     5161 taggcgccga gctcggccag tcgctgcacc gactcgaccg ggtccagggc gcgccgggtg
     5221 gcgtcgccga acgggtcgcg tccctgccag ccgacggtcc agaggccgaa ggtgaacctg
     5281 tcgtcggggg tgggctggta gctcatgcca cggctccttg cttgaagact gtgtcgccga
     5341 ctatttcgtc atggcagttt acaaattagt atgcggacgc atctctggga agacagatcc
     5401 cgcagagccg cggaaaaact tgagggagag cccgatgtca gcagccgagg gtccgctcgt
     5461 cgtcggcgtg gacacgtcca cccagtccac gaaggcgctg gtggtcgacg cggccaccgg
     5521 cgaggtcgtc gcgagcggcc aggcctcgca cacggtgtcc tccggagcgg gccgcgagag
     5581 cgacccccgc cagtggtggg acgccctgcg cgaggccctg caccagtgcg gtgacgcggc
     5641 ccgcgaggcc gccgcggtgt cggtgggcgg ccagcagcac ggactggtca ccctggacga
     5701 gcggggcgag ccggtgcgcc ccgcgctgct gtggaacgac gtgcggtcgg cgccgcaggc
     5761 ccgacggctg accgaggaac tgggcggcgc agggttctgg gccgagcgca ccgggtcggt
     5821 gcccgccgcc tcgttcacgg tcacgaagtg ggcctggctg gcggagaacg agccgcaggc
     5881 cctgcgcgcc accaaggccg tacgcctccc gcacgactac ctcaccgagc gcctcacggg
     5941 cgagggcacc acggaccgcg gcgatgtctc ggggaccggc tggtgggcct ccgcgacgga
     6001 gtcgtacgac gcggagatcc tcgcgcacgt gggactcgac cccgcgctgc tgccccgcgt
     6061 ggtgcggccg ggcgaagtgg cgggcaccgt acgcgacagc cacgacctgc ccttcgccaa
     6121 gggaacgctg gtcgcccccg gcaccggcga caacgccgcg gccgcgctcg gcctcgggct
     6181 gcgccccggc acgcccgtgc tgagcctcgg cacctcgggc acggtgtacg cggtggccaa
     6241 gcaccgcccc accgacccga cgggcacggt ggccggcttc gccgacgccc acggcgactg
     6301 gctgcccctg gcctgcaccc tgaactgcac cctcgccgtc gaccgtgtcg ccgcgctgct
     6361 gggcctggac cgcgaggccg tggaacccgc cgccggcctc accctcctgc cctacctgga
     6421 cggcgagcgc accccgaacc tgccgaacgc ctcgggcctc ctgcacgggc tgcggcacga
     6481 cacgaccgcc ggccagctcc tccaggccgc ctacgacggc gccgtgcact cgctgctcgg
     6541 cgcgctggac ctggtcctgg acgaggacgc ggaccgttcg gccccgctgc tgctgatcgg
     6601 cggcggcgcc cgcggaaagg cctggcagca gaccgtacgc aggctgtcgg gtcggccggt
     6661 ccaggtgccc gaggcgaagg agctcgtcgc gctgggggcg gcggcgcagg cggcgggtct
     6721 gctgaccggc gaggacccgg ccgccgtggc gcggcgctgg aacaccacgc gcggtccggt
     6781 gctggacgcc gtggagcggg acgagtcgac gctggccagg atcgccgggg tactctccga
     6841 cgcggccccg ctcctggacc ggagcacgga catccgctga ccatcgacga atcgacgaat
     6901 cgacggaggc atgaccgcac cgctgcacga ggcccggcag accggccccg ggcgttcgct
     6961 gcccgacacc cagcagggca tgcgccgccg caacctggcc cgggtgatgc acgccgtccg
     7021 tgccgagggg ccgctctcgc gcgcggcggt cgcctcgcgc atcggcctga cccgtgcggc
     7081 ggtctcgacc ctcgtcgacg agctcatacg caccggactg ctcgaggagc tgggccccga
     7141 gcggcccggc cgggtgggcc ggcccggttc cgcgctcgcg gtcagcgggc gcggcccgtc
     7201 ggggataggc gccgagatcg gcgtcgacca cctcgcggtc tgcgccgtcg acctgcgcgg
     7261 tgaggtgcgg gcgcgtgccg tgcggcacgg cacgaaccgg ggccgctccc ccggcccggt
     7321 ggtggaggag ctgaccgcgc tcgtgcgccg ggtggtcgcc gaggccgaac gcgaagggct
     7381 gtggccggcc ggactcgccg tggccgtccc cggcctggtc gcccgcgacg cccggacggt
     7441 cgtccgcgcg ccgaacctcg actggcagga cgtcgatctc ggcgcgctgc tgcccggcga
     7501 gttcgcgctg accgtggaca acgaggccaa cttcggcgga ctggccgaac tctggctcgg
     7561 cgaggacacc ccggcggact tcctgcacgt gtcggccgag atcggcatcg gtgccgcgct
     7621 ggtcgtggac ggcgccctgc tgcgcggcac ccgcggtttc gcgggcgagc tgggccatgt
     7681 gccggtccac cccgacgggc ccgagtgcgt gtgcggcggg cgcggatgtc tcgagcaata
     7741 cgccggcgag gaggcggtgc tgcgtgcggc ggggctggca cccggcgagg accgcgtcgg
     7801 tctgctcgcg gggcgcgccg cggacggcga cccgcaggtg cggcgcgcgc tgcgcgaggc
     7861 gggtacggcc ctgggcatcg ccctgaccgg ggccatcaac ctgctggacc cggagggtgt
     7921 cgtgctcggt ggcgcgctgg ccgggctcgc gccctggctg ctgccgtccc tggagaccga
     7981 actgtcgcgg cgcacggcgg gacccgcccg ccccgtctcc gtgtcacggc tgggacccga
     8041 gggcccgctg ctgggcgcgg cacactccgt ggtgcgggcc gtgctggacg atccctcgat
     8101 ggtggcggaa cgggcctgag cgggcccggc cgctgtcccc tcacccctgg aagccccgtc
     8161 gcgccgggtc gccgacgagg ggctgccaca ggcggaactc cccgttcggg tgagtgaatt
     8221 gtccacaagt ccccgcccgt ccacgagatc acggcgtgcc ctcgcaccgg cccgtcggcc
     8281 cgtactttgt cgacagaccg gcgtacttca ccgacgccct ctacgagagc tccgcccggc
     8341 tgacggcgtc cgtctgcgac cggtacggca tcccgaagga ccgcacgcgc gtgatcggcc
     8401 actacgaggt gccggggagc gaccacaggg accccggtcc gcactgggag tggagtcgct
     8461 acctgcgtct cgtcgaccgc acctggcgcg aaccggacgg gcgcggggcg cccgcttccg
     8521 gatgaccggc gtcgaaacgg ttgtcggccc gcgcacccgg agtgacgatg tccccagccg
     8581 tactccggtc gcaggccggg gtacgccagc cgtgtccccg ccgtactccg gccgtatcgc
     8641 cttccgggag gacgagttga ccgattcctg ggtggctctg gagccgggtg ccgacccggc
     8701 cgagcgggtg cgggtcctgc ggcgggcgca cgaggcgttc accgaggcgg gaaccgtgcc
     8761 gcgtccggta cgccccgtcg tggccgactc ctggcggcgt tccgcgcggg cgggcgtcgg
     8821 ccccgacggc accgcgagcg tcgagctcac cgacggcgac ctcggcgcct accgggccga
     8881 acatccgctg gcccgggtga tgccgctgtt ccgagagctg atgggcacgt tcgcggccga
     8941 cggggagcac ctgctcgccg tgtgcgacgc gcacggcagg ctgttgtggg tcgaggggca
     9001 cgcggcgacc cgtcggcagg cggaccggat gaacttcgtg ccgggtgcgc gctgggcgga
     9061 gagcgcggtc ggcacgaacg cgccgggcac ggcggtcgcc ctggaccggc ctgtgcaggt
     9121 cttcgcggcc gagcacttca tccgccgggt gcagccgtgg acgtgcgcgg ccgccccggt
     9181 gcacgacccg cgcaccgggc gggtgctggg cgccgtggac atcaccggcg ggaacggcct
     9241 ggcgcatccg cacagcctgg gtttcgtgca ggcggtggcg cgggccgccg aggcgcacct
     9301 ggccctgctc gcccccgagc cgcccgccgc cgacacaccg cggctgaccg tgctgggccg
     9361 ggacgaggcc cgactggtca ccggcggccg cgagatcaga ctgagccgtc ggcacagcga
     9421 gatcctgatc ctgctggccg gccgcccgga gggcatgacg ggcgacgaac tgctgtgcgc
     9481 gctgtacgag gacgagtcgg tgaccccggt gaccctgcgg gccgaactcg cccggctgcg
     9541 cggggtgctc ggccccgggc tcctggcctc gcgaccctac cggctcaccg cggcgatcga
     9601 gtcggacgtc gcggtcgtcg aacgcaggct cgcggccggc gcggtcacgg cggccgtgac
     9661 cgcgtacacc ggcccgccgc tgccgacgtc ccgggcaccg gccgtggtgc ggctcgggaa
     9721 gcggctcgcc gacgggctgc gcgccgcgct gatcgcctgt ggtgaccccg atctgctggc
     9781 cgactgggcc cacgcaccat ggggcgagga cgacctcgag gtgtggcagg cgctggcggc
     9841 ggtccgcccc accgccgcga tacgggcccg cctcgcgtca ctccggtcgg aactcacggc
     9901 accggccgga tggccgcgcc cctgagggtg ttcatccgcg tcgcgcccgc cggcacggct
     9961 cccccgggcg ggcgcaacgt ggatgcaacg tccttctccc tagcctgcgg cgcagagcgg
    10021 ctgtccaacg gcgggcagcg ctgctgaagg aggcagagca ggatgacccg ttacgcggcg
    10081 cccggcaccg agggcgcgat cgtctcctac caggcgcggt acgaccactt catcggcggc
    10141 gcgtacgtgc ccccggcccg gggccggtac ttcgacaacc cctccccggt gaacggcgag
    10201 gccttcaccg aggtggcgcg cggcacggcg gaggacgtgg agcgggcgct cgacgcggcg
    10261 cacgcggccg cgccgggctg gggccgcacc tcggccaccg aacgctccga catcctgctg
    10321 aagatcgccg atcgtatgga ggcacacctc gaagccctgg cggtcgcgga gagctgggag
    10381 aacggcaaac ccgtccggga gacgctggcg gcggacatcc cgctggccat cgaccacttc
    10441 cgctacttcg cgggagcggt cagggcccag gagggttccc tcagcgaggt cgacgacgac
    10501 acggtggcct atcacttcca cgagccactc ggcgtcgtcg cccagatcat cccgtggaac
    10561 ttcccgatcc tgatggcgac atggaagctc gcgcccgccc tcgcggccgg gaacacggtc
    10621 gtcctcaaac ccgccgagca gacgcccgtg tccatccact actggatgag cctgatcgcc
    10681 gacctgctgc cgccgggcgt gatcaacatc gtcaacggct tcggcgagga ggccggcaag
    10741 ccactcgcgt ccagtccgcg cgtggcgaag atcgccttca cgggcgagac gtcgacgggg
    10801 cggttgatca tgcagtacgc ctcgcagaac ctcaagcccg tcacgctgga gctgggcggc
    10861 aagtcgccga acatcttctt cgacgacgtg tgggagaagg acgacgacct gcgcgacaag
    10921 gccctcgaag gcttcaccat gttcgcgctg aaccagggtg aggtctgcac ctgcccgtcg
    10981 cgtggcctga tccagcgcgg caactacggc gacttcctcc aggccgccgt ggcccgcacc
    11041 gaactcatca agcccggcca tcccctggac accgacacga tgatcggggc gcaggcgtcc
    11101 ggcgaccagc tcgcgaagat cctctcctac atcgacatag gccggaagga gggcgccaag
    11161 atcctcaccg gcggcgaacg cgccgagtac gagggtgact tgaagggcgg ctactacgtg
    11221 cagccgacca tcttcgaggg cgacaaccgg atgcggatct tccaggagga gatcttcggt
    11281 ccggtcgtgt cggtggcctc cttcggcgac ttcgacgacg ccatcaagat cgccaacgac
    11341 acgtcgtacg gcctcggggc cggtgtctgg acgcgcgaca tcaacaccgc ctaccgcgcg
    11401 ggccgggcca tccaggcggg ccgcgtctgg acgaactgct accacgccta cccggcgcac
    11461 gccgccttcg gcggctacaa gcagtcgggc atcggccgcg agacgcacaa gatgatgctg
    11521 gagcactacc agcagacgaa gaaccttctg gtgtcgtact cgccgaagaa gctgggcttc
    11581 ttctagacgc tgcgaaaggg cgcctgacct ggattttcac ccgtaaggcg cccttcgctc
    11641 aacccgctct cgaccgggcc cggccggcgc gccgactccc cactcctccc acgactgccc
    11701 gccgtcgagg aacttggcgt atttgtggag tctccggcgc gggccgggcc gcggcctgac
    11761 gtcaggactg ctccgccgcc agggcgcaga gttgtgaacg gttgggcagc ccggtcttgg
    11821 cgatcaggct ggcgacgtgc ttctcgacgg tgcgcggcga tatgtagagc cggacggcga
    11881 tgtccttgtt gctgggtcgg tcggcgagca gccggaagat ctcgtactcg cggaccgtca
    11941 tgcccttcat gcgcagttcc ggtggaatcc ggtcgctgcc ggtgcggtgc tggcgcaccg
    12001 gtgcgccgat cgcgcgcagc agggtccggc aggcgccgac caccgcggtg gcggaggtct
    12061 cgcggaagtg gtgctcggct tccctcagcc atctctccgg ttcgccccag ctcagcgcgt
    12121 gggcctcctc cgcgatcagc cgctgcccga gatggcgggc ggtgggatag ggcgcccccg
    12181 tggtctcggc gaggagcgcc gcttgtccgg ccgcctcggg ccggccctcg cggccgagca
    12241 ggacggcctc ggcaagcagg aggaagtacc ggttccaacg catccggccg gcggcgctgg
    12301 cggtcagccg gtcgaggtga gcgcggtcgg cccggccgtc caggaggtcg agcagcagag
    12361 cgaggccgtg ccgtccgctc aggtggaaag tggtcgggtt ctcggcctcc agcgccttga
    12421 ggtcggccat gacaccggcc gcctggtccc ggttctcctc caagagggca cagaagacct
    12481 gggccaggcc gagggccagc ggctcctcca gcgagccgcg ccctccccag cgtccgaagt
    12541 cggccagggc ctcctccatg gcggtacggt cgccctggtg agccgccagc accgagcggg
    12601 ccatcagcag gtatcgggcc accgacgtca gcttcaggcg ggctgccatg gtcagcgtct
    12661 cgtcgccgag tgcccgggcc tcggtgaacc ggccgcgcag tacatcgtgc agggtgagga
    12721 tgccgtcgat gccgtagacg acggtgaccg cgcccagcct ccgggcctcg gtgcgggcct
    12781 cctcgagggt ggcggtactg ccgtcgtcca gccaccggat gccgccgagg cgggtgagcg
    12841 cgtacatccg ctggagtggc aggctgtgcc gttcggcggt gctcatggcc tgctccagat
    12901 aggtactggc ctcggagagg tcacgttcgc gggcgaccac ggcgaggagt tcccctgcct
    12961 ggcaggcgac caggggcagg ccctcccgct cggcggtgcc gagcgcggcg cgggccagcc
    13021 gctcggcccg ctgggtgcgg tcctgtcccg gcgtgtcgag gcacaggtac gcctccacca
    13081 cgtcggtcag cgcggtgtgc gcctcgtccg gcgccgtcgc cagcagcgcg cgagcccgtt
    13141 cgatctgact gttgccgtcg gcccagcggc ccgccatgta cgccacgtgc gcgaggcggg
    13201 tgtgcagggc cgccagccgg gccgcgccca ggccggctcc gacgagttca cgcagggttc
    13261 cggtgaggct gagcgcgcgg gtcagttccc cggtctccgc gagcgcgggc agcagcgctt
    13321 ccagcgcctc ggcgcgggcg acggagtccc cgccttccgc cagcagccgc tcggcgcggt
    13381 cgagcaacgc gaccgcggat cccaccgcgc cgtcggcgag ggcacggcgc ccggcctcgg
    13441 cgaacagccg gccgccccgt acggggtcac cggcgtcggc gcgcagggtc gccgccagcg
    13501 ggcaccagtc gcccggcaga ccggggttga gggtctcgat cgcgttcgcg gcctgctcgg
    13561 acagtgccac tcgggcggcc ggggtgagct gtgcgagcag cgcttcggcg gtcagcggat
    13621 gctggaaggc gtaccagtcg ggggcgggtt cgtcggccgc gaccagccgg gccgccacgc
    13681 tcgcgtgcag gtggctgagc aggctccggt cgtcgacgcc ggtcatcgac tggagcaccg
    13741 acagggggaa ccgccggccg agtacggccg cggcgctgag cacggtccgc ccctgtgggc
    13801 cgagttggtc gatgcggtga atggcgccct ccagcagcgc cctgggcatg ttgcggcgga
    13861 ggtcgccgac cacccgccag gcggcgccct cgcggacgag cgagccgccg gcgaccgccc
    13921 cctggagaag ttcctcgacc aggaacggga tgcccgcgct gtcctgccac atctggacga
    13981 gcacctcggc aggcagccgg ccggggtcgg tttccaggca ggaggcgatc atccggccga
    14041 ccccgtcggc gtccaacggt gccagccgga agaccgtcgc gctgcgacgg cgcccggcgg
    14101 actcggcgag gctcagcgcc tcgccgggat cggacctgat ggtcgccgcc agcatgagcg
    14161 gctgatgctc gaggttgtcc accaggtact cgacgacggc gagggtttcg gtgtcggcgt
    14221 cgtgcagatc ctccagcacc agcaggcagc cgctctcacg gccggcgtgg gcgagcaccc
    14281 gcagcaccgc ttcggcgagc accacggtcg atccctggtc gggggagccg gtgctccagc
    14341 ccgggatgag ccggccgagc accgggcggt acggtccgag gctcgcctcg tccggtgtca
    14401 ccccgccgcg ggagagcggc atcagggcct cggtgagcgg ccggagcggc accatgggtc
    14461 cgatggtgct gctccggccc ttcaggaccc ggacgccggc gtccagcgcg gatccgatca
    14521 gctcggcgac cagccgcgac ttgccgattc ctccctctcc gaccagaaac gccgtgcctc
    14581 cgcgtgaccg gttcagatcc cgtaacgatt cgccgagctc ggtgacttcg gcctcacgac
    14641 caatgagatg agctgcccgc agacgcatac ctccggatgg tagtcactcg ctcacgaagg
    14701 tcacacacct gctcgaaccg gccgggcgtg acgtcaggtc aggcgggcac cgacacggtg
    14761 gtgatggtgg cggagccgag gccgaccacc acgccgctgc cgagggtcat tccggccagc
    14821 gcccgggtcc gggcgcacgc cccgttccag cggaccagcc ggatctcgcc ggccgggtcg
    14881 gtgaccgtcg cggacgcgcc cgtggcctcg tcgtggacgg taccgttctg cgggaagctg
    14941 gacatggttc ttcctttcgg tggacatgga tccgactcgg gatcgcactg ttgatgaact
    15001 gttcgtattt ccgcaaaggt tctcgtggtg ctcgcggcgc gggcaccggt tcggacggcg
    15061 gtacgagggc actcagtccc gtccgccgcc ctgggcgggg ccgagcaaga ggaccgaggg
    15121 cacggtgtcg gcgaagccca gccggagcag ggcgtagccg atgcccgaca gcccggtgag
    15181 cagtccgggc gtcggtacgc gcccgggtgt cccgcagctg ggcccccagg cgtgaagcag
    15241 tccgaggacc aggccgatcc ggccggtcag gctgcttcgc gcctcggcgt ggccgcaccc
    15301 ggcgagggcg gccaccgctt ccgcgatacc cagctcgccg tggcacaggc tgaggtcggc
    15361 caccggcgga tgctcgatga gcctgcggct cgcgtcccgg gccggaccgt tcgccgactg
    15421 cgggcagagc ccggcgtcgg ccgccgccag tacgacgccg gcggtgcccc ggcaccagcc
    15481 cgcgtcgagc cggtccgccg ccgcgagtgc ggtggtcagc cgggtgcgtc cggccgcctc
    15541 ggtccgcgcg cccagtggac cgccggcgaa ccgggcgtgc cgggccagcg cccagccgat
    15601 cccggcctcg ccgaaggcga agccgaagct ctccggcgca ccgtcaccgg gccgaccggc
    15661 cggcgcaagc cccagcaacc gttcggcgat ccggtcggcg aggtcggcgg cctggggcag
    15721 cccgcgctcg cggtacaccg cgagcagagc ggcgagcgct ccggccaggc cggccgacac
    15781 acccggtggg gtgtcgtcgc cgagcgccgc cagcgccaag gcgtccagcg ccgtcggcag
    15841 gcacccggcg agatcgtcgt cgaccagggt ggccacccgg gcgagcgcgt agcagactcc
    15901 gcccaggcct tcgaagccgc ccgggccgac ggcccggctc agggccgggt cggcagccat
    15961 cgcggcgacg agttcgggca ccggggcgag cgccgcccgg gccagctcgg tgtgccgggc
    16021 ggagccggtg agcgcgccga gctgggccag gaacagggcc accccgctgt atccctgggc
    16081 cagcccggcg cccatgggca gcaccgtcca gcggtcgtcg accgcctcca ggccgaccca
    16141 gttggcccgg ccgtgtccgc cgacggcccg gccggcgatc tcgtcggcga tcccggaggc
    16201 ggcggccagc agcgcggagg gttccggcag gacggcggga gcgggactgg cccggcggct
    16261 cacccggtgg cggcgtccgg cggcgcacgg ctccgcggat gccagggtgg ccgagatgat
    16321 ccattcctgg gcacggcggt cgacggtgct catggcggcg agcttcgccc gtgaggaggc
    16381 gaggccggag gtgtccagga caccgctcac cgggctcccg tccgcggcga agacctccgt
    16441 tgagccgggc cggtggaaga agacggggac gtcgccgtcc cacaggtcgg cgatctcgta
    16501 ctcgatgagg gcctggcggg ccgggtcgcc gtccgaatcg gcccacagca ccgcgaacat
    16561 ggcatcccgg tcgagcccgt cgcgcagcac ctgcggatgc gtcgcctcct ccagcagggt
    16621 ggcgtacagc atcgtcggcc ggaccacgag ccgaccgacc gcgtccccgc cggcgcccag
    16681 cggcccggcg ggcgtggaca gttcgtcgcg gtgccggacg acggcgtcgt acccggtgcg
    16741 gaatcccgcc aggaccgcgg ccacccggtc ggcgctgccg gggccggccg cggcgctgta
    16801 gggacggttc agcgcgccgg tgaacggcgc cgggcgacgc accatccgca tctcgtccgt
    16861 gccggcgtcc tcccagacca tccgggtatc gggggactcc ccgcccggtg caccgcccag
    16921 cgcggagacg tcgaccgcgc ccagctctcc caccatgagc tgcggcagca ggcaggtgcg
    16981 gtgcaccgag gaggcgtgtg ccccggcggc cggatccggc cgggtggtcc cgccctcccg
    17041 caggacgggg tgcagcagtg tctcgacgtc gaccagcacg ggctggtcgc cgtgcgcgag
    17101 gacgttctcg tagtgcaggt ccaccccttc gagggtgtag gccagcgcga tcagcacacc
    17161 ctgccgacgg tggaaccggt cgatctcggc cagcgaacgg cacgtccggt ggtcgatgta
    17221 ctccagccac ccgtagccgt cgccggccac ccagcgcggg gtgcgcagcc ccaggcccgg
    17281 ggctttggcg tccagccagc cggccatcct gtccagcagg gcgtgctggt cgaccggccg
    17341 cggcttgtag accgcgctgc cggcggcgaa ccggagcacc gccaccgacc tgccctgctg
    17401 gtgcaggtcc ccgagtccca gctcgacgcc gaccagcggg cccgggtccc gcccgccgaa
    17461 cagctcgtcg gcgagcttct gccggtcggt ggcgagccgc gccagcagtt cggcgccgga
    17521 ccgggcggtg cgccggcagg tcagggccag cagacgggcg agcaccgggt atccggcgaa
    17581 cagccgggcc agacccgcgc gggtgccggc ccgggcggcg aagtcggcga agcgggcggc
    17641 cgaggtggag ccggacaggt cgcccgcggt ccgcgcggcg gccagctcga cgaccagggt
    17701 ccgggcggcc gttctggtga gtcgccgtac cagccagtcc gcgtagtccc cggcgaacac
    17761 cgccgtctct ccggggtcgg caccgtccgc tccggcctgt tcggccagct cggcgacggc
    17821 cgccgtcacc agcgggcgca gtaccggtcc gaagaccacc gctccgtccg ccgggtcggc
    17881 gggcgcggtc accgctgccc cacggacctc cgcgggcgtc tcgggggccg cggcgagcgc
    17941 cccttccacg aacaccgccc actgcggctt ggcgagtcgc ccggccaggc gggccggagg
    18001 ttcggcggcg agtgccgcca ccagctcggt gtcggcgccc agtcgggccg agcggacgga
    18061 ttcgcaggcc gactcgaccg gtgagcgggt gcgcagccgg gcggccgggg tggcctgtgc
    18121 cggcgccggc gggtgcgggg ccgacaggcg ctcacgcagt gtcgcggccg gtgcccacca
    18181 ggagggtgtc gcctccgtgg cgggacgggc ggtgtcggtt ggggtcacgt ccgtcaccct
    18241 tccagcggtg tcgcccaccc gtacaggggg gcaggacccc cacattccgc ggcggactac
    18301 ccagttggcg ccaccgccgg gcccctttcg cgctgccggg cgggtcggcg ggagcggtgg
    18361 gcggcgacga cggcgccgcg gccggggcga gcgggccggg cggccgggct ccgtccggcg
    18421 gcgcgcggcc gtgtgcggtc cggccgtcgg tgtacgggcc ggggccggcg cggcggggca
    18481 cgggaatgcg ggtagtcgcg ccccatgcgg cgcggcgcac gggttgccga gactcctcgc
    18541 cgagaggttc gtcctgcgct gaccgaggag tacacatggg caatcccctg tcgttgtgcg
    18601 tcgtggccct ggacccgctg ctcgaagccg gtgccgtcag cgccctgtcc ggcaacccgg
    18661 acatcgcact ggtccggccg gaggagaagg ccgacgtggc cgtggtgatc ttcgaccgag
    18721 tggatcgcga ggaactcgat ctggtggccg cgaccggcgg cggcccgcac cggcccgccg
    18781 tcatcgtgat cgcctcccac atgtcggcgg ccgaggccgc ggacgccgtc aacgccgggg
    18841 cccgcggcct cctgcgccgg cacgaggtgg acgccgaccg gctggcgcgg accgtgcgaa
    18901 ccgtggccgg cggcgactgc accgtgcccc ccgacctgat cgacggcctg ctcgaccaga
    18961 gcaccgagac cgacgcgtat cccggcgtac ggggccgcgg cccggactgg gggctggacg
    19021 agcgggaacg cgcggtcctg cggatggtgg ccgacggccg ggagaccgat gagatcgcca
    19081 aggaactctg ctactcgccg cggacggtga ccaccgtggt ccgcgacatc acccagcggt
    19141 tccggctgcg caaccgcgcc cacgcggtgg cctacgcgct gcggacgggc ctgctgtgac
    19201 cggcctcgtc ctcgaagcgg cgccggttgc cgggcgggac gacggcgcgc cgcgcgtaca
    19261 tctgtgcccg gcgggcgggg cggcccgcga cacggtcgcc gccggtctgc gccgggccgg
    19321 cgtcgagctg gtggcggccg gagaccgcga cggggtcgtc cgggttgccg cgggccggac
    19381 gccgggagcg gcgctcgagg gccgaccgga acccggcggc ggccctctcc tgctggtcgc
    19441 cgacaccttc accgccgcgg gagtgcggct ggccgtgcgg gccggggtga cggcgatgct
    19501 tcagtccgcc gaggccacgc cggagcgcct gctcaccgcc gtccacgccg cccggtacgg
    19561 cgacaaccgg atgccgtacg gcgtactggc ccgtctcctc gacgaagcgg ccggcgacga
    19621 ggcggagcgc cggcaccccg tgcccgactc gcccctgacg gcccggcaga agacggtact
    19681 cgcgctggtc gccgaggggc acggcaacgc cgccatcgcc cgtgaactgt cctgctccca
    19741 gcacaccgtg aagaacgtca tgtacgacct catgacccgc cttcaggtcc gcaaccgggc
    19801 gcacgcggtg gcgtacggcg tccgcaccgg gctgatctga gccggtcccg gtcccgacca
    19861 gagacattga cgcagcaaaa gccgcgacgg gcgctgccgc tccttcccta ctgcgcagcc
    19921 acgcccgaac ggcaagctcc ggacgtgccc cgaccacccg aggcacgcga cgacctaccc
    19981 gactcctcgg aggtgagccg gtggaccgct gtgacggccg gacgacatcc ttctcgcagc
    20041 aacgactgtg gttcctcgac caactgcgac ccggcacggc ggaccatctg cttccgctgg
    20101 cgctgcgcct gcggggcgac ctcgacaccg aggccctcgc cgcggccctg gccgacgtgg
    20161 tcgaccggca cgaggtgctg cgcacccggt atgcggccgc cgacggcgag ccggtggccc
    20221 atgtggtccc ccgggtcgag gttttgctgg acagggtcga cgcgcccgcc gccggagcgg
    20281 ccggcatcgc cgcggtcctc gaccgcgcgc tgcgccggcc ggtcgacctg tcgaccgcgc
    20341 cgccgctgcg ggccactctg gcgcggctcg cgcccgacga ccacctgctg gtcgtcgtgg
    20401 tccaccacat cgccttcgac ttctcctcct ggaacgtcct cacccgagac ctggccgcgg
    20461 cctaccgcgg caggaccacc ggtgtccgcc acgggctgcc ggagcttccc gtgcagtact
    20521 ccgacctcgc ggcccttcag cgcgagcggt cggccggtcc ccggctcgcc cgcggcctcg
    20581 accactggcg ctcgcggctg gcgggcctgc cgccgctgga cctgccgacc gaccggcccc
    20641 gcccggccga gttcgacggc gccgccgccg tggcccggtt caccctccct gccgatctgg
    20701 tggcgctgac cgaccggctg gcgcgctccc gccgcgccac ccgtttcatg gtgctgctcg
    20761 cggccttcca ggcccaactg ggccgctaca gcgggcagag cgacttcgcc gtcggcaccc
    20821 cggtcgccgg tcgcggccac cccgccgcca gggacctcat cggccccttc gtcaacaccg
    20881 tggtgctgcg cgccgacctg tccggccgac ccggtttcgg cgagctggtg gaccgggtcc
    20941 ggcacacctt cctggccgac ctcacgcacg ccgacacccc gttcgaacgc gtggtcggcg
    21001 agctggcccc gtcccgcgac ctcagccgca accccctctt ccaggtctcc ttcctgaccc
    21061 tcgactccca ggccgaacca cccgacctgc ccggcctgtc ggtcgaagtg gtgcccaccc
    21121 cggtcgccgg gacgccgttc gacctggcgc tcgacctgct cggccgcccc gacggcagcc
    21181 tcgggctgcg cctggggtac gccaccgcgc tgttcacgcc cgagacggcc gcccgcatca
    21241 ccgaggacta cgtccggctc ctgcacgagc tgctcgccgc ccccgacaag ccgctggccg
    21301 gtgtcacctc cgtactcgag ccgctgcccg gcggcgagcg ccgccgccgg ctcgcgctcg
    21361 gcctgggcag cgcccgcgcc gtgcccccgc agaccgtcac cgacctgttc gagcagcagt
    21421 cgcgccgcac cccgcacgcc attgccgtca gttccgggga cggcgagctg agctacgccg
    21481 gactcgaccg gcgggccgac gaactggcac accgactgcg cggcctcggc gtcggccgcg
    21541 gcacccgggt gggcgttctg ctggagcgcg gcaccgggct cctcgtcgcc ctgctcggcg
    21601 ttctcaaggc ggacgccgcc tacgtgccgc tcgacccgct gcaccccgcg cggcgcatcg
    21661 gccacctgat cgaggacacc agggccgccg tggtcgtcac caccggcccg ctggccggac
    21721 gggtggccgg caccgaggca cggacccttc tgctcgacgg cgacccgccg ccggccggcc
    21781 cggcggaccg gcgggagcgg accaccggac cgcacgacct cgcgtacgtc ttccacacct
    21841 ccggctcgac cggcaccccc aagggcgtgc agatcccgca ccacgccctg accaacttcc
    21901 tgctcgccat ggcggcccgg ctggagacgg ggccggaggc caccgtgctg ggtgtcacca
    21961 ccgcctcctt cgacccctcg atgctggagc tgtgcctgcc gctgctgacc ggcgcccggc
    22021 tggtgctggc cgacagcgag caggcccgcg accccgagcg cctgatccgg ctgatcggcg
    22081 aggcccgccc ggacttgatg caggccaccc cgtcgatgct gcggacactg gtcgacacgg
    22141 gctggacccc cggcccaggt cttacggtgc tgtccggcgg agagaagctg cacaccgacc
    22201 tggccgcggc gctcgcggcg gacggagccc cggtcctgga cctctacggg ccgaccgagg
    22261 ccacgatctg gaccagcgtg gcccggcacg gcgccgacgg acgggtggag cggtgggcgg
    22321 cggtggacaa cacgaccgtc cgggtgctcg acgaccggct ggagccggtg gccgagggcg
    22381 tcaccgggca cgtctgcatc gggggcgacg gcctcgcatg gggctaccgg gggcggcccg
    22441 cccagaccgc cggcgtcttc ctccccgacc cgcacgccac cgcgcccggc ggccggctgt
    22501 acttcaccgg cgacctcggc cggatccgtc cggacggctc actggagatc ctcggccgca
    22561 gcgaccacca ggtgaagatc cgcggccacc ggatcgaacc gggcgagatc gaggccgcgc
    22621 tcctcgctct cgacggcgtc cgcgccgccg tggtgcaccc gacgccggac gccgacggcg
    22681 gtcagcagct caccgcgtac ctggtcgcgg acgactccgg gaaccctccc acccccgacg
    22741 ccctgcgcgc cgaactgctc gactccctgc cccaccatct ggtgccggcc gcgttcgtcc
    22801 tgctggacgc catcccgacc gcggtcagcg ggaaggtgga ccgccacgcg ctcccggtgc
    22861 cggcgccgca ggcggccggc ccggcggccg ctccgcgcac cccgcgggaa cggtccgtgg
    22921 ccagggtctg ggaagaggtc ctcggcgcca ccgggatcgg cgcccacgac gacttcttcc
    22981 tgctcggcgg tcactcgctg ctcgccaccc gggtgtccgt gcgcctgcgc gccgccctcg
    23041 gggtggacgt ccccgtacgg gcgctgttcg accaccccac cgtcgccgcc ctcgccacgg
    23101 ccctggacgg ctatccaccg ctggccccgg acggccccct gccgcggctg accgcacgcc
    23161 cgcgcggcgc gcgcacgacc gccggccgct gaccgcaacc acctcctcgc ccaaggaccg
    23221 ccatgacact cctcgcgacc accgacacct ccgtcttcga gaagatcgag tccgaggtgc
    23281 ggatgtactg ccgtaccttc cccgtggtgt tcgagcgcgc caagggcgcg ctgctgcaca
    23341 ccgacgatgg ccggcccttc atcgacttct tctgcggcgc cggcagcctc aactacggac
    23401 acaaccacga cgccgtcaag cggcgcatca tcgactacct cgccgacgac ggcctcatgc
    23461 acggcctcga catgcacacc gtcgccaagc gcgacttcct cacccgcctc accgaggtcg
    23521 tgttgcagcc gcgcggcctg gacttcaagg tgcagttcac cggcccgacc gggaccgacg
    23581 cggtcgaggc ggccctcaaa ctggcccgcc gggcgacggg ccgcaccggc ctgaccgcct
    23641 tcaccggtgc ctaccacggg atgtcccgcg gttcgctgga ggtcaccggc agccgccgcg
    23701 cccgccgcgc gggcacggtc gccggcgggg acgtgacctt cgtccccttc gaggacggcc
    23761 cgctcggccc gttcgactcg atcggcctga tcgagcggct gtgggcggac ccgtcctccg
    23821 gcaccgaacc gcccgcggcc gtcgtcgtcg aatcggtaca gatggagggc ggcgtctacc
    23881 cggcgagccg ggagtggctg cgccggctgc gcgaggtcac cgaacggcac ggggtgctgc
    23941 tgatcctgga cgagatccag accggctgcg gccgcaccgg cgcgttcttc ggcttcgagg
    24001 agtccgggat cgtgccggac atcgtcaccg tctccaagtc cctcagcggc tacgggctgc
    24061 cgctctcgct cacgctgttc cgccgcgagc tggacctgtg gcagcccggt gagcacaccg
    24121 gcacgttccg cggcaaccag ctcgccttcg tcgcggccac cgcagcctgt gaactgtggc
    24181 agcaagacga cttcctgagc ggccttcagc agggtgcgga gcggctggcc cggttccggg
    24241 ccgacgcggc cgcgctggac cccggcctcg tggtgcgcgg ccggggcatg gtgctgggcg
    24301 tcgacaccgc cggggccggc ggtgcggagc gggccgagcg cgtccagcga cacgccttcg
    24361 agcgcggcct gatcgtcgag cgctgcggcc gctacgacga ggtcctcaag gtgatgcccc
    24421 cgctgacgat cgagcccggt ctgctcgacg acgggctcgg catcctgctc gacgccctgc
    24481 aagcgaactg acggccggcc acccgaggag gaaccccgcg atgccccgtc ccgaccgcca
    24541 ccacctgatc tccgtcgacg acctgaccga ccgggagctg cgccggctcg tgcaccgcgg
    24601 cgcccagtac gccgccggcg agtgcgaggg tgcccggccg ctcgccgacg ccgtcgtcgg
    24661 cgtgctgttc cgcaagacgt ccacccgtac ccggaccgcg ttctcggccg gcgcgctccg
    24721 gctcggcgcg cggctgatca cctatggtcc cggcgacctc caggagaaca ccggggagag
    24781 ctccgaggac accggcgacg tcctctcccg gatgctcgac gtgctggtgg cgcgcaccgc
    24841 gggcagcacc gaggagctgc gcgcctacgc cgcccagcag cggatggccg tgatcaacgc
    24901 gatgagcgcc gccgagcacc ccacccaggc cctcaccgac ctcaccacga tgctcggccg
    24961 cttcgggcgg atcgagggac tgcgggtgct gtacgccggc gagggcaaca acaccgcctc
    25021 ggcgctcgcc ctggccctca gccggttccg cggcaccgag ctgcacctgc ggaccccgcc
    25081 cggctacgga ctggacgcgg ccttcctcga ccgggccgcc gtgcacgcca aggagtccgg
    25141 cgcgctggtc gaggaacggc acaacatggc cgacctgccc gaggtcgaca tcgtctacac
    25201 cacccgctgg cagaccaccg gcacgaccaa gcccgacccc gactggcggc gcgtgttcgc
    25261 ccccttccgg gtggacgccg ccgtgctggc ggcctgcccc ggcgccgtct tcatgcacga
    25321 cctgcccgcg caccgcggcg acgaggtgac cggcgaggtg ctggacggcc ccgcgagcat
    25381 cgcgttccag caggccgaga acaagtacca cagcgcccgc gccgttctgg agtggtgcct
    25441 cggcggcatc ccggcagagc cggcctgacg accggccgac cgccggcccg gcgcactctt
    25501 cccagggagg tagcacagca atgtccgaca ccatacgcat gcccggcggc gggtggcgcc
    25561 tgtggacgca cttcgcactg cgcgggcccg gtttccccgc cgcgggagta ctacggctgg
    25621 ccccggaggg cctggcctcg gccgcggaca agttcgcccc cggggaggtg ccggcggggg
    25681 cggactggca ggcgttcgag gaggccttct cggcggccgc ggtgcgcacc gcacgcgacc
    25741 tccaggagat cgccgcctcg gcaccgttcc gcgccgcggt cgcctggcag aaccgcacgg
    25801 tgctgcgcac cggcatcaag ccgttcctcg actggacacc gtccgccgag ggccgcacca
    25861 gcatgccccg ccaacgcgag gaactggtcg cccactactg gcagcggttc tgcgtcaaga
    25921 acgacaccat cggcttcttc ggaccggtcg gctggggcac cttcgacccc tcccggcacg
    25981 acatcgaggt gcaccccggc acgggtctgg tcgccgagtc ccgggtctac ttctccagtt
    26041 ggtcgatgga cgccctcgcg aaggccatcg accgcgaccc gcgggtgcgc gcgtggacgc
    26101 cgccgcgcca ggttccgttc gtccgggtgg tcgacggcgc ggtgcgcctg cccggccgcc
    26161 cgccgcagcc ggctccggaa cccgcgctca ccgtcctgcg cctgtgcgac gggcgccgga
    26221 cgcccgccga gatcaccgcc ctggcagccc gggagctggg ccgcgacctg ccggccgggg
    26281 aggtgaccga ggccctggag tggctggtct cgcgccgcct gatcggctgg aagctggacg
    26341 tgcccgccgg tacctacccc gagcgggaac tgcgcgccat gctggagcgc atcggcgacc
    26401 cggcggtacg ggaacccgcc ctggccaagc tggcggtgct ggagaccggc cgcgaccggg
    26461 tccagcgggc gggtgccgac cccgaggagc tgaccgccgc gctcgccgcc ctggaggcgg
    26521 gcttcgccga gatcaccgag gtgtcggcgg tccgcgagaa gggggcccgc accgcgccca
    26581 accgcgccct ggtgtacgcc gactgccgcc ggtccgccac ggcgaccgtg ggcaccgccg
    26641 tgctggccag gctcgctccg ctggagctgt gcctgaccgc cgcgcgctgg atgaccaacc
    26701 ggtacgcgga ggccatcgtc gcccgcgtcc acgaggccta ccaggagctg cggaagctgc
    26761 acgagcaggt cgacctcggc tcgctctggt tcgcctgcct gcccgccccg caccccgaat
    26821 ccctcaccga catcgagcgc atccaggccg agctgcgcga gcgctgggcg cggatcatcg
    26881 acgccccggc cggcgcccgg cgggtctcgc tctccagtgc cgccatcgcc gaccgggtgc
    26941 acgaggcgtt ccccgacggc gggcgcggct ggtcgctcag ccgctacatc agccccgacc
    27001 tgatgatcgt cgccgaagac gcggccgccg tcgaacgcgg cgagttccaa ctcgtcatcg
    27061 gcgagctgca cgtcgccatg aacaccctcg cccagtcgct cttcgtccac cagcaccccg
    27121 atcgggagca gctgatcgac gagaccaccc gcgacttccc cggcccacgg ctgctgccca
    27181 tgctgcccaa ggagcttccg ctcaagtggt ccgcccgcag ccggcagtcc ctggaccgcc
    27241 cggaggacca ctacgtcgca ctcgccgacc acagcgccga cccgcaccgc ccgcgcaccg
    27301 tccgctccgg cgaggtgcgg gtggaggagc gcgacggcgg gctcgcggcc gtgctgcccg
    27361 acggctcggt cttcgacctg ctcgacgtgt tctgccacgc gctcagcaac cgtgtgatgg
    27421 accgcttcac cctgcgccgg gacggcgacc actcgccccg gatcaccatc gactccaccg
    27481 tcgtcgcgcg ggagagctgg cggttcgccg gctccgcgct ggccttcgcc gacgacaaga
    27541 gc
//
