LOCUS       NZ_BMSI01000005        22622 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence05, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000005
VERSION     NZ_BMSI01000005.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 447467)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 48859
            Orig. end                         :: 71481
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22622
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="2"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22622
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22622
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12622](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12622
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    538..555
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.28"
                     /tool="antismash"
     misc_feature    complement(552..569)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.2"
                     /tool="antismash"
     misc_feature    complement(651..668)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.93"
                     /tool="antismash"
     gene            707..2365
                     /locus_tag="IE189_RS14445"
                     /old_locus_tag="GCM10010496_29490"
     CDS             707..2365
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257: Alpha-glucosidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127373.1"
                     /locus_tag="IE189_RS14445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29490"
                     /product="glycoside hydrolase family 13 protein"
                     /protein_id="WP_189921539.1"
                     /sec_met_domain="Alpha-amylase (E-value: 6.8e-76, bitscore:
                     250.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQHIDTRSDTPRWWREAVIYQVYVRSFLDSTGDGVGDLAGVRA
                     GLPYLKKLGVDGIWLSPFYPSPQHDHGYDVSDYCDVDPLFGDLDEFDRLVAAARRLGVK
                     VLLDIVPNHCSSEHPWFREALASAPGSPARARFHFADGRGTDGAEPPNNWHAMFGGPAW
                     SRVTEADGSPGQWYLHMFTPEQPDWNWREPEVAAHFERVLRFWLDRGVDGFRIDVAAGL
                     FKHPALPDSPDPEADARTRDSVNPLAWNQPEVHDVWRRWRTVCEQYSARDGRERLLVGE
                     VSVPTAREHARYVRPDELHQAFFFDLLSASWDADAFRKVITEAMQDIAGTGSTVTWVLN
                     NHDQVRTVTRYGEPAVEGSGLGAARARAAALLLLALPGAAYIYQGEELGLPEVVDLPDD
                     VLTDPIFRRTGSRARIRDGCRVPLPWSGQASPFGFTSGVDGTKPWLPQPEYFAEYATDR
                     ALADTRSFWHLYRDGLQLRATLPQLGEGTLRWLDTQPGVLAFARGDGLVCAVNFGTAPA
                     PAPVPGVPLLSSGPCRAGVLPGSTAAWWIGDDTGS"
     gene            2419..3747
                     /locus_tag="IE189_RS14450"
                     /old_locus_tag="GCM10010496_29500"
     CDS             2419..3747
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436123.1"
                     /locus_tag="IE189_RS14450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29500"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_189921541.1"
                     /transl_table=11
                     /translation="MMRRRTTLLTGCTALALAFGATACGGGGPVSAGGGDQALSGQTVS
                     VAGVWSGAEQKNFQKVLDAFTEKTGAKTQFVSTGDNVSTVVGSKIEGGNAPDVVMVPQV
                     GVLQQFAAQGWLQPLSPAVRKSVTANYAPVWKNYGSVKGTLYGLYFKAAHKSTVWYSPD
                     ALDQAGVKPPKTYDDLLEAGHAVSDSGLAAFSVAGQDGWTLTDWFENVYLSQAGPEKYD
                     ALAAHELKWTDQSVVDALTTLGRLFKDKQLLAGGQKGALNTDFPGSVEKVFGPKPQAGM
                     VYEGDFVAGVAKDQFGRKIGEDANFFPFPPVGGGTAPVVSGGDAAVVLKDGENAKAGMA
                     LLEYLATPQAAAVWAEAGGFLSPNKKLDPATYGDDVTRTTAESLIAAGDSVRFDMSDQA
                     PAAFGGTKGAGEWKVLQDFLRDPSDPKATAAQLETAAAKAYKG"
     gene            3753..5108
                     /locus_tag="IE189_RS14455"
                     /old_locus_tag="GCM10010496_29510"
     CDS             3753..5108
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527485.1"
                     /locus_tag="IE189_RS14455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29510"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_189921543.1"
                     /transl_table=11
                     /translation="MTATLTKTAPPPAATAARKWRARRRGRTLALLFVLPALLLLGALV
                     VYPVLFSVGRSFFDASGTRFVGGDNYTEMFRDPATLKAVRNTAVWVVVAPTLLTGLGLI
                     LAVLVEKVRWATAFKLLLFMPMAVSFLAAGIIFRLAYDEDPDKGVLNAAAVGIHDAFRD
                     TSSYPTARARDGQGITHGADGSYRTGTTVSPGDTVALGMVGVPPKELPAGAGPARAAAA
                     RQAGPDELRGVVYLDFTPGGGGRQGVVDSRESGLPGMTVQAVRDGKTVASTTTAADGSF
                     RFGGLEAGPYTVALPGSNFAPPYDGVSWLGPALVTPAIIGAYLWIWTGFAMVLIGAGLS
                     TLPRDSLEAARMDGANEWQVFRRITVPLLAPVLTVVFVTLVINVMKVFDLVYIIAPGPV
                     QEDATVLATQMWLVSFGGGNDQGLGSALGVLLLLLVVPAMVFNVRRFRGSQR"
     gene            5105..5950
                     /locus_tag="IE189_RS14460"
                     /old_locus_tag="GCM10010496_29520"
     CDS             5105..5950
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127376.1"
                     /locus_tag="IE189_RS14460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29520"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_189921545.1"
                     /transl_table=11
                     /translation="MKLSALRRGLGNSAVQAVLVVVGLLWLTPLAGLLVSSLRSARDTA
                     EGGWWTALTSPGQLSFDNYSALLGNAGITRAFWNTVLISVPATFLVVVIAALAGYAFAW
                     LEFPGRDVLFLLVVALLVVPVQIGLLPVAKLFGQLGLFGTIPGVVLFHVSYGLPFAIFL
                     LRNYFAEIPREMLEAARMDGGSEWRIFTRLVVPVGRPALASLAIFQFLWVWNDMLVALL
                     FADSSAQPLTVELQSQIRQFGSNIDVLAPGAFLSLIVPVAVFFAFQRHFVQGVMAGSVK
                     "
     gene            complement(5973..7772)
                     /locus_tag="IE189_RS14465"
                     /old_locus_tag="GCM10010496_29530"
     CDS             complement(5973..7772)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="IE189_RS14465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29530"
                     /product="protein kinase"
                     /protein_id="WP_189921548.1"
                     /sec_met_domain="Pkinase (E-value: 3.3e-53, bitscore:
                     175.4, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.2e-06, bitscore: 23.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLAARYELLDAVGRGGMGEVWKATDRELGRTVAVKVLPPELTR
                     HEEFRVRFRREARTVASLNHRNVAVLHDVGEDTTDGETTPFLVMEFIRGRTLTDVLADG
                     AFTVERALAVGRDIADALAHSHAQGLIHRDIKPSNVMLTSEGGIKVLDFGIAKVVAETT
                     TRLTATGMTVGTPAYLSPEQLTGEPVDGRSDQYSTGCLLYELLTGRPPFLGDSPFAVMH
                     QHISQEPVAPSRLRPQIPAVVDDLVLRTLAKDRAHRLGSAAELRDTLDATLIALSGPAA
                     VPGPRAAAPAPGAPDAPAGPPGRARADSATGPGHTALAEQETRTAPAPPRPAAPPPGGP
                     AAPAHPGAPGTPGDVRTPSDSAGERRLALGGGRPVALLGIVVSGVVGFGYLDAFGDSDD
                     EFVAVWMAAVVLGLALFRWLPLTSALLWWGAGALVVASVSIGGASHDYDTTTVTESSFG
                     TLYSYDSTYQTYSELPTDSSGYHLFESDYSGGYAPAQAEIYPDSAAHDDIEVFAVPVLV
                     LAALCLFRALDRRRLSTLAAACGVTLGGLGVGWLAFGSDEQAGAFSLAWGLVVVAAVVQ
                     EVRARRSAPPRARRRLRFVTTEQ"
     gene            complement(8016..9224)
                     /locus_tag="IE189_RS14470"
                     /old_locus_tag="GCM10010496_29540"
     CDS             complement(8016..9224)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961169.1"
                     /locus_tag="IE189_RS14470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29540"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_189921550.1"
                     /transl_table=11
                     /translation="MTRDRIGLAEVLAAAEQAAPVGSLDIVARNLRDRFGARYVSFLFV
                     DVVGRRLLRVNEKGEAGEHRAEQVPLAGSSVYDEVLRTQKLVRTAEEGNGHGQRVLAPV
                     TNRGDTIGVLELFLGQVTEDVLEQVGEAAHALAYIIVTDRRFTDLYHWGNRTTSVSLAA
                     EIQRQLLPSASSCEAAEFDLAGALVPASDIAGDTYDYSLDQDTLHLSVTDAMGHDVDAS
                     LMATLLVNASRGARRAGADLAEQARQTHQALLDHGRRTFATGQLVRIALDGSRAQLVNA
                     GHPWPLRLRDGTVEELRLAVNMPFGAVGQGAYRVQDLDLRPGDRLVLYTDGMQERDAQT
                     VDLRRLLAETAAEHPREAVRTMVGAVRDAYAGRQPRDDATVLCLDWHGSRYGGLRQDVA
                     GGA"
     misc_feature    complement(9782..9796)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            10001..12622
                     /gene="lanKC"
                     /locus_tag="IE189_RS14475"
                     /old_locus_tag="GCM10010496_29550"
     CDS             10001..12622
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127261.1"
                     /locus_tag="IE189_RS14475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29550"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_189921552.1"
                     /sec_met_domain="micKC (E-value: 9.9e-280, bitscore: 924.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 8.6e-11, bitscore: 36.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.6e-16, bitscore:
                     54.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYEAFSYADKVFYDSPVRWAAMEEFAAVGEPLPAGWLSSSREVW
                     VGRRPADVELPDQGWKIHVSACMDNAEHILAVVGAYCVERRVAYKFLRSPALVQTQNAK
                     YASRGSSGKFMTLYPVDEPELERCLTELDEALAGLRGPYILSDLRWRNGPLYLRYGGFT
                     EQFCRSETGELVLALREPSGRLRPDVRRAVFEVPDWAPVPAVLAQALADRAATSRAEFP
                     YTVERALHFSNGGGIYMGRPVGGGDEVVLKEARPDAGLDQRGDDAVLRLGREHDILRRL
                     EGIPAVPRALDYLTAWEHHFLVQEYVPGETLNRWFGRRYPLVHPDPGRDTIDRYREEAL
                     TVLAGIEEGLSAIHARGVVFGDLHPRNLIVRPDGRVCFVDFELASPVDAFVRPALGAAG
                     FAAPPDLHGLAIDRYALDALRLWIFMPLLQLTSLDPGKRDELVAAATRRFGIPADAVGG
                     RPDAPPGATAPPAPAHAPPSGPTASRPAGREAPAGLFSGDRADWPALRDSLAAAIDASA
                     TPERTDRLFPGDPSQFTHDGLGLAYGAAGVLWALHTVGAQVRPGHVEWLEEAVAREPCR
                     PGLYTGAHGVAFALDRLGRVRQAHNLLDRLLKDPLDGQGSDLAGGLPGIGLTLLHFADT
                     TADASLHAVALDVADRLAARLKPDAATAGPAPGRRPGLLHGPSGAALFFLALHDSTGDS
                     VLLDLAEQALDLDLARCVLGEDGTLQVDDGSRVLPYLESGSAGIAAALHALLRHRPDPD
                     RQRSLDQIRGAAEPEFIVQSGLFNGRAGLILLLHLLQDGTGAHAPVVRRHIRRLVWHLV
                     PYEGHAAFPGEQLLRLSMDLATGSAGVLLALGSALADTPALPFWNGRRVAEPAPLPLPE
                     AS"
     misc_feature    complement(10009..10020)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.38"
                     /tool="antismash"
     misc_feature    10097..10099
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12709..12723)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.15"
                     /tool="antismash"
     gene            12717..12842
                     /locus_tag="IE189_RS14480"
                     /old_locus_tag="GCM10010496_29560"
     CDS             12717..12842
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998309.1"
                     /locus_tag="IE189_RS14480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29560"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_020127262.1"
                     /transl_table=11
                     /translation="MSILSLQALETPEETTEYLSVLSSLSAVNCTNSTVSTLLCL"
     CDS_motif       12717..12776
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSILSLQALETPEETTEYLS"
                     /locus_tag="IE189_RS14480_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12777..12842
                     /prepeptide="core"
                     /locus_tag="IE189_RS14480_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="7.10"
                     /molecular_weight="1981.3"
                     /monoisotopic_mass="1980.1"
                     /core_sequence="VLSSLSAVNCTNSTVSTLLCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSILSLQALETPEETTEYLS"
                     /leader_location="[12716:12776](+)"
                     /alternative_weights="1999.3"
                     /alternative_weights="2017.3"
                     /alternative_weights="2035.4"
                     /alternative_weights="2053.4"
                     /alternative_weights="2071.4"
                     /alternative_weights="2089.4"
     misc_feature    complement(13064..13076)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     gene            13139..14803
                     /locus_tag="IE189_RS14485"
                     /old_locus_tag="GCM10010496_29570"
     CDS             13139..14803
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998310.1"
                     /locus_tag="IE189_RS14485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29570"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_229901245.1"
                     /transl_table=11
                     /translation="MTGSSAAALLLPGVLATAVDRALSGGATTGGALPLAAVLALLTAA
                     ETLAQYAGPRTTAEATARLRAALVRHLMATGLSPDRRTTTGDLVARLTASAAEAGLSVQ
                     AAVYAVAQLAMAAGSVVALGLLAPELAAAFLVTAPAGWLLLRRQLRRTVRRGEGYQEAQ
                     AAVAARLLDALAGRRTIAAAGTVDREIERVLGPVPELSRHGRALWDSQRRVAWSTGLLA
                     PATQITVIAVAGYELSTGTLGAGDLVAALGYATLGLGGFGAAQSFLDHARARAGHRRVQ
                     EVLARPRQPPGLRRLPPGPGRVELRGVTVRRSDATVLDALDLTLPAGRCVALVGRSGAA
                     TSLLAAVAGGLVTPERGTVLLDGVPTDEIRPGDLRAAVAYAFADPELTGATVFDALAVA
                     AEPLPADRVRAAARAAQADTFVRRLPAGYRTPVRDAPLSGGQRQRLGLARALARDGRLL
                     VLDDATSSLDSATEAAVLRALDDTHGGRTRLVVTRRTATAARADLVAWLHEGRIRKVAP
                     HDELWRVPAYRRMFLGTDDTTDAPDTEDVIPAEAPER"
     gene            14865..16763
                     /locus_tag="IE189_RS14490"
                     /old_locus_tag="GCM10010496_29580"
     CDS             14865..16763
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127264.1"
                     /locus_tag="IE189_RS14490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29580"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189921556.1"
                     /transl_table=11
                     /translation="MADRTARPPHRAARHRTPPGPRTPQGTAPHGTPARGTAYRTARSL
                     ASANGTALRLIRDSLAARRAAALRLTWWTLLSAAPALVSGKALALAVDQGFLAGRPRTA
                     ALGLGLFAVCTLGGAWASRQTYPWLAEIVEPKRDRLLRDVVTGTLHRAVAPGPDRGDDG
                     AAVAVARLTRQVEAVRDALAGQLMLLWQFVLTVVAVVAGTAVVAPAAVALVAAPLLVAL
                     ALFALLAPASVRRQREAFDAEEKLAARTVETLTALRDIVACGAHDHARREALDAVGHHL
                     RTSRALASVSALRRLIVALGAHSPLLLVVLAAPGLHARGTTAGAIVGVLGYVLATLEPA
                     IRLLVQGLGASWLRLAVAAERLAEAARLPDPLPDPDPGLRPADGSAKLRGVTFAYGPRA
                     EPVLDGLDLSLADGEHLVVVGPSGIGKSTLADVLTGMLSPCRGQVVLGGVPLDRVAGAE
                     RARARVLLPQTPYVFAGTLRENLCYLAPGTPDRVLAEAVTELGMTDLVERLGGVDGHVG
                     PAGLSLGERELVALARAYLSDAGLVVLDEATGHLDAAAEQQVEEAFRRRPGTVVTIAHR
                     MNAARRADRVLLLDGSRPRLGTHRALLDDVPFYRDLMGHWDTGAAGAGRTGADRAG"
     gene            complement(16769..17458)
                     /locus_tag="IE189_RS14495"
                     /old_locus_tag="GCM10010496_29590"
     CDS             complement(16769..17458)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (1-162). E-value: 1.8e-10. Score:
                     33.0. Matches aSDomain:
                     nrpspksdomains_IE189_RS14495_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563415.1"
                     /locus_tag="IE189_RS14495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29590"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_189921558.1"
                     /transl_table=11
                     /translation="MGVHLITGAGSGIGAAVATLFTSRGQELWLLARDEARAADLRARF
                     PGSRTLVADLSEPGSVRPRLEAQELPARLDSLLHVAGVVESGRVGELGARVWQDTLAVN
                     LIAPAELTGLLLPALRKGRGHVVFVNSGAGVHAPPRLSAYAASKFGLKALAESLRAEEY
                     AHGVRVTTVYPGETDTPMQVRLHEQFGLPYDPDAHMSPASVAAAVVTALDLPRDATMSD
                     LMLRPGS"
     aSDomain        complement(16973..17455)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS14495_PKS_KR.1"
                     /evalue="1.80E-10"
                     /label="IE189_RS14495_PKS_KR.1"
                     /locus_tag="IE189_RS14495"
                     /protein_end="162"
                     /protein_start="1"
                     /score="33.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="GVHLITGAGSGIGAAVATLFTSRGQELWLLARDEARAADLRARFP
                     GSRTLVADLSEPGSVRPRLEAQELPARLDSLLHVAGVVESGRVGELGARVWQDTLAVNL
                     IAPAELTGLLLPALRKGRGHVVFVNSGAGVHAPPRLSAYAASKFGLKALAESLRAEE"
     misc_feature    complement(17249..17251)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(17381..17452)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS14495_0001"
                     /evalue="1.20E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE189_RS14495"
                     /protein_end="26"
                     /protein_start="2"
                     /score="11.5"
                     /tool="antismash"
                     /translation="VHLITGAGSGIGAAVATLFTSRGQ"
     gene            complement(17560..17877)
                     /locus_tag="IE189_RS14500"
                     /old_locus_tag="GCM10010496_29600"
     CDS             complement(17560..17877)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126512.1"
                     /locus_tag="IE189_RS14500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29600"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_189921560.1"
                     /transl_table=11
                     /translation="MPTQLTLTHGRTSAGGSLLTVAGEIDMSNSTTLADAIDDVRGPLV
                     VDLTGVEYLDSAGLNVLFAHAERLEIVATPLLQPVLAVSGLARLVEVRLRPDDDTGTPP
                     R"
     gene            complement(17877..21845)
                     /locus_tag="IE189_RS14505"
                     /old_locus_tag="GCM10010496_29610"
     CDS             complement(17877..21845)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020139777.1"
                     /locus_tag="IE189_RS14505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29610"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_229901284.1"
                     /transl_table=11
                     /translation="MWMAWGPDLTFLCNAAYRHNTLGRKYPWALGLPAAEVWSEIWPAV
                     APRVDRVLSTGEATWDEGLQLFLERSGYREETYHTFSYSPLREDAGAVVGMLCVVSEDT
                     ERVIGARRMATLRDLGSDPSVIRTETETLAFLGRQLEHNLADLPFTLTYLLDDDGAHLA
                     CTTGMPAGHPAAPEFLSPDDPGAPWPVAALADGATVQTELDPRLAAGLPSGAWTEPPVQ
                     ALVVPLVQPGAAPYGFLVAALNRYRELDEEYRGFVELVAGYLAAGIGTARGYRAQQRRA
                     EELAELDRAKTTFFSNISHEFRTPLALISGPVEELQKRLADADGQIGQELAAIHRNALR
                     LGKLVNTLLDFSRIEAGRMQASYEPVDLAALTAELASVFRSAVDRAGLDLVVDCPPLDR
                     PVHVDRDMWEKVMLNLLSNALKFTFEGSLHVTVREEDDRAVVTVTDTGVGIAADEMPRL
                     FERFHRISGVRARSHEGSGIGLALVRELVVLHGGTISAESTPGLGTRFTVRLPFGSAHL
                     PADAVREPSRSRPASSAAVPYVQEALRWLPAGTGTAVRDKSAHDPSTPPAGSPPAERAR
                     ILVADDNADMREYLVRILSEAGYRADAVSDGLAALAAARARTPDLIVSDVMMPLMDGLA
                     LVGALRSDTRTASVPVLLLSARAGQEASIEGLSAGADDYLVKPFAAAELLARVRANVEL
                     ARLRTHHVRWRAALVDSLQEALLVMDDTGTVLEINAAFTQMLGHGTEGLPYSRAHPWWP
                     DAGTDPEAHRQVADAFAHLLTHGHGNHTLPLVHRNGHRLYVSAAFNDARDPDSGRRMIV
                     GTFRDVTAERHAVQRESALASLSTRLAEATGLDEALTASLEQLRELWHAEHVLSAVFAD
                     GPPRLTATRPLTWQDIPAERRRTIGDLRNQPLLTAVHETTGAGVLLEHPDGPMALWIEL
                     GPGRRFSPEDELLLALLAGHLAQALTRAHQIDQQRETALTLQRAILGPSRLPEGFAARY
                     EPATPPLEVGGDWYDVVELPDGRIGIVVGDCVGRGLQAATVMGQLRSACRALFLQDPSP
                     ARTLSALDHFARGIPGAMCTTVFCGVLDPRTGDLTYSSAGHPPGVLALPDGSTRRLEAG
                     HALPLAVRPDLGRPEHVCPIPARSSLLVYTDGLVERRRQPLDVGIDQAGEVMGAGRDLG
                     ARELADRLMAELAPANGYDDDVALLLYRHPGPLQFAFPAESGQLAGARHALREWLARCE
                     LPRRTAQDVLIAAGEACANAVEHGHRAFHEGIIRLSAETSSDTVRVTVADSGSWKPGNP
                     ADTPHRGRGLGIMKALAHEVTITPGPSGTTVEMHTRIA"
ORIGIN
        1 tcttcctgcg caactggccc tacgcctacg tcagcgcctc ggccgccggc tcggcggtcg
       61 cgggccgggt cggcgccgta cccctgcccg gccgcgacgg gcccggtacg agcgtcctcg
      121 gcggctccaa cctcgccgtc aacacgcacg ccgagcaccc cgacaccgcc gcgcgtctga
      181 tcgcgtacct caccggcgag ggggtccagc ggcaggtgct cactcgcggc gcgctgcccc
      241 ccgtacgcgc cgacctgtac gaggacccgg agctggtgcg ccggttcccg tatctgccga
      301 ccctgcgcga gagcgtgctg acggccgccc cgcgccccaa gagcccccgc tacgaccagg
      361 tcagcatggt ggtccaggcg gtcgtgcacg acgcgctggc cgggtatgcg acgcccgcgg
      421 ccgcggcgcg gcggctggcc cgggaactgg cggacatccc ccgcaacggc tgacgtacgc
      481 ccgtcggcgc gtcgctgtac gtcttctcct cgggccgcgc tccggcccgc cccctcctag
      541 ttacatgtta ggtaacgccg gcatatcaac cggtggcgat ttgtcctggt ggatccatat
      601 atgcctgccg attcgccgaa tccctggcgc ccactcgttg acacctccgt gaaacgccta
      661 cataacatgc atgcataaca gtcagcccgc acagacaggc caacgggtga gcacccagca
      721 catcgacacg cgcagcgaca cgccccgctg gtggcgtgag gcagtgatct accaggtgta
      781 cgtccgcagc ttcctggaca gcaccggcga cggcgtcggc gatctcgccg gagtgcgcgc
      841 cggactgccg tacctcaaga agctgggcgt cgacgggatc tggctgagcc ccttctaccc
      901 ctccccgcag cacgaccacg gctacgacgt ctccgactac tgcgacgtcg acccgctctt
      961 cggcgacctc gacgagttcg accggctggt ggcggccgcc cggcgcctgg gcgtcaaggt
     1021 gctgctcgac atcgtcccca accactgctc cagcgagcac ccctggttcc gcgaggccct
     1081 ggcctcggcg ccgggaagtc ccgcgcgggc ccgcttccac ttcgccgacg gccgcgggac
     1141 ggacggagcc gaaccgccca acaactggca cgccatgttc ggcggtccgg cctggagccg
     1201 cgtgaccgag gcggacggca gccccggcca gtggtacctg cacatgttca cgcccgaaca
     1261 gcccgactgg aactggcgcg aaccggaggt cgccgcccac ttcgagcgcg tgctgcgctt
     1321 ctggctggac cggggcgtgg acggcttccg catcgacgtc gccgcgggcc tcttcaagca
     1381 ccccgccctg cccgactcgc ccgaccccga ggcggacgcc cgcacccgcg actcggtcaa
     1441 cccgctcgcc tggaaccagc ccgaggtgca cgacgtgtgg cgccgctggc ggacggtctg
     1501 cgagcagtac tccgcccgcg acggccgcga acggctcctg gtcggcgagg tgtcggtgcc
     1561 gaccgcccgc gagcacgcca ggtacgtccg ccccgacgag ctgcaccagg ccttcttctt
     1621 cgacctgctc agcgcctcct gggacgccga cgccttccgc aaggtcatca cggaggccat
     1681 gcaggacatc gcggggaccg gatcgaccgt cacctgggtc ctcaacaacc acgaccaggt
     1741 ccgcacggtc acccgctacg gcgagccggc cgtcgagggc agcggactcg gcgccgcccg
     1801 cgcccgcgcc gccgccctcc tgctgctggc cctgcccggc gccgcctaca tctaccaggg
     1861 cgaggaactg ggcctgcccg aggtcgtcga cctgcccgac gacgtgctca ccgacccgat
     1921 cttccgccgc accggaagcc gcgcccgcat ccgggacggc tgccgggtgc cgctgccctg
     1981 gtccggccag gcctcaccgt tcggcttcac ctccggggtc gacggcacca agccctggct
     2041 accgcagccc gagtacttcg ccgagtacgc caccgaccgc gccctcgccg acacccgttc
     2101 cttctggcac ctctaccgcg acggcctcca gttgcgcgcc accctgcccc agctcggcga
     2161 gggcaccctg cgctggctcg acacccagcc cggcgtcctc gccttcgccc gcggcgacgg
     2221 cctggtctgc gccgtcaact tcggcacggc gcccgccccg gcgcccgtcc cgggcgttcc
     2281 cctgctgtcc agcggcccct gccgggccgg ggtcctcccc ggttccacgg ccgcctggtg
     2341 gatcggcgac gacaccggtt cctgagcccg gcccacccct atcccgtcaa ctccccatcc
     2401 ttcgaaggga catcaacgat gatgcgacga cgtaccactc tgctcaccgg ctgcacggca
     2461 ctcgccctcg cgttcggcgc gaccgcctgc ggaggaggcg gccccgtctc cgcgggcggc
     2521 ggcgaccagg cactgagcgg ccagacggtc tccgtggccg gtgtctggtc cggcgccgag
     2581 cagaagaact tccagaaggt gctggacgcc ttcaccgaga agaccggcgc caagacccag
     2641 ttcgtctcca ccggcgacaa cgtctccacc gtcgtcggca gcaagatcga aggcggcaac
     2701 gcccccgacg tcgtcatggt cccgcaggtc ggcgtgctcc agcagttcgc cgcacagggc
     2761 tggctccagc cgttgtcacc ggccgtccgg aagtcggtca ccgccaacta cgcgccggtc
     2821 tggaagaact acggcagcgt caagggcacc ctgtacggcc tctacttcaa ggccgcccac
     2881 aagtcgaccg tctggtacag ccccgacgcc ctcgaccagg cgggcgtcaa gccgccgaag
     2941 acctacgacg acctgctcga ggccggtcac gccgtctccg actccggcct cgccgccttc
     3001 tccgtcgcgg gccaggacgg ctggaccctc accgactggt tcgagaacgt ctacctctcc
     3061 caggcgggcc ccgagaagta cgacgccctc gccgcgcacg aactcaagtg gaccgaccag
     3121 agcgtggtcg acgccctcac cacgctcggc aggctcttca aggacaagca gctgctggcg
     3181 ggcggccaga agggggccct caacaccgac ttccccggat ccgtcgagaa ggtcttcggg
     3241 ccgaagccgc aggcgggcat ggtctacgag ggcgacttcg tggccggggt ggccaaggac
     3301 cagttcggcc gcaagatcgg cgaggacgcg aacttcttcc ccttcccgcc cgtcggcggc
     3361 ggcaccgcac ccgtggtcag cggcggcgac gcggccgtcg tcctcaagga cggcgagaac
     3421 gccaaggccg gcatggcgct cctggagtac ctcgccaccc cgcaggccgc cgccgtgtgg
     3481 gccgaggcgg gcggtttcct ctctcccaac aagaagctcg accccgccac ctacggcgac
     3541 gacgtcaccc ggaccaccgc cgagtccctc atagccgccg gtgactccgt ccgcttcgac
     3601 atgtccgacc aggcaccggc cgcgttcggc ggcacgaagg gcgccggcga gtggaaggtc
     3661 ctccaggact tcctgcgcga cccctccgac ccgaaggcga cggccgcgca gctggagacc
     3721 gccgcggcca aggcctacaa gggctgacgg ggatgaccgc caccctcacg aagacggccc
     3781 cgccgcccgc cgccaccgcc gcccgaaagt ggcgggcccg gcggcggggc cggaccctcg
     3841 ccctgctctt cgtcctgccc gcactgctcc tgctcggcgc cctggtcgtc tacccggtgc
     3901 tgttctcggt cgggcgcagc ttcttcgacg cctccgggac ccggttcgtg ggcggcgaca
     3961 actacaccga gatgttccgc gaccccgcca cgctcaaggc cgtacgcaac accgcggtct
     4021 gggtggtcgt ggcgccgacc ctgctgaccg gcctcggcct gatcctcgcc gtcctcgtcg
     4081 agaaggtgcg ctgggcgacg gcgttcaagc tgctgctctt catgcccatg gccgtctcct
     4141 tcctggccgc gggcatcatc ttccggctgg cctacgacga ggaccccgac aagggcgtcc
     4201 tgaacgcggc ggccgtcggg atccacgacg ccttccgtga cacctcctcc tacccgacgg
     4261 cccgggcccg tgacggccag ggcatcaccc acggcgccga cggctcctac cgcaccggca
     4321 cgaccgtgtc gccgggcgac accgtcgccc tcggcatggt cggcgtaccg cccaaggagc
     4381 ttccggcggg cgccggaccc gcccgggcgg cggccgcccg ccaggccggc cccgacgaac
     4441 tgcgcggcgt ggtctacctg gacttcaccc ccggcggggg cgggagacag ggagtggtgg
     4501 acagccggga gagcgggctg cccgggatga cggtccaggc tgtgcgggac gggaagaccg
     4561 tcgcgagcac caccaccgcg gccgacggct ccttccgctt cgggggactg gaggcgggcc
     4621 cgtacaccgt cgccctcccg ggctcgaact tcgccccgcc ctacgacggc gtctcctggc
     4681 tcggtcccgc actggtcacc ccggcgatca tcggcgccta cctgtggatc tggaccggct
     4741 tcgcgatggt gctgatcggc gcgggcctgt ccacgctgcc gcgcgattcg ctggaggcgg
     4801 cgcggatgga cggcgccaac gaatggcagg tgttccgccg gatcaccgtg ccgctgctgg
     4861 cacccgtgct gacggtggtc ttcgtgaccc tcgtcatcaa cgtgatgaag gtgttcgacc
     4921 tcgtctacat catcgcgccc ggcccggtgc aggaggacgc caccgtcctg gccacccaga
     4981 tgtggctggt ctccttcggc ggcggcaacg accaggggct cggcagcgcc ctcggtgtgc
     5041 tgctcctgct gctggtcgtg cccgccatgg tcttcaacgt ccgccgcttc cgagggagtc
     5101 agcgatgaaa ctcagtgcgc tgcggcgcgg gctcggcaac agtgcggtgc aggccgtcct
     5161 cgtggtcgtc ggcctgctct ggctgacacc gctcgccgga ctgctcgtgt cgtccctgcg
     5221 gtcggcccgg gacacggccg agggcggctg gtggaccgcg ctcaccagcc cgggacagct
     5281 ctccttcgac aactactcgg cgctgctggg caacgccggc atcacccggg cgttctggaa
     5341 caccgtgctc atctcggtgc cggcgacgtt cctcgtggtg gtgatcgccg cgctggccgg
     5401 atacgccttc gcctggctgg agttccccgg ccgtgacgtc ctcttcctcc tcgtcgtggc
     5461 actcctcgtg gtgcccgtgc agatcggtct gctgccggtg gccaaactct tcggccagct
     5521 ggggctgttc ggcacgatcc cgggcgtcgt cctcttccac gtctcctacg gactgccgtt
     5581 cgcgatcttc ctgctgcgca actacttcgc cgagatcccg cgggagatgc tggaggcggc
     5641 ccgcatggac gggggcagcg agtggcgcat cttcacccgg ctcgtggtgc cggtgggacg
     5701 gcccgccctg gcgagcctgg ccatcttcca gttcctgtgg gtgtggaacg acatgctggt
     5761 ggccctgctc ttcgccgaca gctcggcaca gccgctgacc gtggaactcc agtcacagat
     5821 aaggcagttc ggcagcaaca tcgatgtgct ggcgccgggc gcgttcctct cgctgatcgt
     5881 gccggtggcc gtgttcttcg ccttccagcg ccacttcgtc cagggcgtca tggcggggtc
     5941 ggtgaagtag ccggcgggcc ggcccgccgg ggtcactgct cggtcgtgac gaaccgcaga
     6001 cggcgccggg cgcgcggcgg ggcgctcctg cgggcacgga cctcctggac cacggcggcg
     6061 acgaccacca ggccccaggc cagcgagaac gcccctgcct gctcgtccga tccgaacgcc
     6121 agccagccga cgcccagacc gcccagggtg accccgcagg ccgccgccag ggtcgacagc
     6181 cgccgccggt ccagggcgcg gaacaggcag agcgcggcga ggacgaggac cgggacggcg
     6241 aacacctcga tgtcgtcgtg cgcggcggaa tcggggtaga tctcggcctg cgccggggcg
     6301 tacccgccgc tgtagtcgct ctcgaagagg tggtagccgg aggagtcggt gggcagctcg
     6361 gagtaggtct ggtaggtcga gtcgtaggaa tagagcgtgc cgaaactgct ctccgtcacc
     6421 gtggtggtgt cgtagtcgtg cgaggcgccg ccgatgctga cactcgcgac gaccagggct
     6481 cccgctcccc accacaggag ggccgaggtg aggggaagcc agcggaacag ggcgaggccg
     6541 agcacgacgg cggccatcca cacggcgacg aactcgtcgt ccgagtcacc gaaggcgtcc
     6601 aggtagccga agccgacgac gccggacacc acgatgccca gcagggcgac cggtctgccg
     6661 ccgcccaggg cgagccgccg ctcacccgcg gagtccgacg gcgtccgcac atcacccggg
     6721 gtgcctgggg ctcccgggtg tgcgggggcg gcaggtccgc ccggcggtgg cgcggcgggt
     6781 cggggcggag ccggcgcggt gcgggtctcc tgctcggcca gggccgtgtg cccgggaccc
     6841 gtcgccgagt cggcccgtgc gcgtccgggc ggcccggcgg gcgcgtcggg cgcgcccgga
     6901 gccggtgcgg cggcccgcgg gcccggcacg gccgccgggc cgctcagtgc gatgagggtc
     6961 gcgtccagcg tgtcgcgcag ctccgcggcg ctgcccagcc ggtgcgcacg gtccttggcc
     7021 agggtccgca gcacgaggtc gtcgaccacg gccgggatct gcgggcgcag ccgggagggc
     7081 gcgaccggct cctggctgat gtgctggtgc atcaccgcga aaggggagtc cccgaggaac
     7141 ggcgggcgcc ccgtcagcag ttcgtacagc agacagcccg tggagtactg gtcggagcgg
     7201 ccgtccaccg gctcaccggt gagctgttcg ggggagaggt aggcgggcgt gcccacggtc
     7261 atgcccgtcg cggtgagccg cgtggtggtc tccgcgacga ccttcgcgat cccgaagtcc
     7321 agtaccttga tgccgccttc ggacgtcagc atgacgttgg acggcttgat gtcgcggtgg
     7381 atcaggccct gggcgtggct gtgggcgagg gcgtccgcga tgtccctgcc gaccgccagg
     7441 gcccgctcga ccgtgaacgc gccgtcggcc agcacgtccg tcagggtgcg ccctcggatg
     7501 aactccatca ccaggaacgg cgtcgtctcg ccgtcggtgg tgtcctcccc gacgtcgtgc
     7561 agcacggcga cattgcggtg gttgagggag gcgacggtgc gcgcctcccg tcggaagcgg
     7621 acccggaact cctcgtgccg ggtgagctcc ggcggcagca ccttcacggc tacggtgcgc
     7681 ccgagctccc ggtcggtggc cttccagacc tctcccattc cgccgcgtcc gaccgcgtcg
     7741 agcagttcgt accgcgccgc gagcacccgc atggtcctgc cccctggtga catgggccgg
     7801 ccccgccaca gcccggcggc ccgaagttcc ggatcacggc agaggaaggg gcggcgccac
     7861 cggcaacccc cggcgccgcg gtgcccttcg cgcggccgcc cgctcaccat actggcggga
     7921 attcacgcag gggacaatcg gcgcccggta gtacaaatgt gcgccatatg tgggtcgtcg
     7981 gcaccgggtt tccgccatgc ggtgcgtacg acgcgtcagg ctccgccggc gacgtcctgg
     8041 cggagtcctc cgtagcggga gccgtgccag tcgaggcaca ggacggtggc gtcgtccctc
     8101 ggctgccggc cggcgtaggc gtcccggacc gccccgacca tcgtgcggac ggcctcgcgc
     8161 ggatgctcgg ccgcggtctc ggccagcagg cggcgcaggt cgacggtctg cgcgtcgcgt
     8221 tcctgcatgc cgtcggtgta gagcacgaga cggtcgccgg ggcgcaggtc caggtcctgc
     8281 acccggtacg cgccctgtcc gacggcgccg aagggcatgt tcaccgccag ccgcagctcc
     8341 tcgaccgtgc cgtcgcgcaa ccgcagcggc caggggtgac cggcgttgac gagctgcgct
     8401 ctgctcccgt cgagcgcgat gcgcaccagc tggccggtgg cgaaggtgcg ccggccgtgg
     8461 tccaggaggg cctggtgggt ctggcgggcc tgttcggcga ggtcggcccc ggcgcggcgg
     8521 gcgcctcggg aggcgttgac cagcagggtg gccatgagtg aggcgtccac gtcgtggccc
     8581 atggcgtcgg tgacggacag gtgcagggtg tcctggtcca gggagtagtc gtaggtgtcg
     8641 ccggcgatgt cggaggccgg gaccagggcg cccgcgaggt cgaattcggc cgcttcgcag
     8701 gacgaggccg agggcagcag ctggcgctgg atctccgcgg cgagactgac cgaggtggtg
     8761 cggttgcccc agtggtagag gtcggtgaag cggcggtcgg tgacgatgat gtacgccagc
     8821 gcgtgcgcgg cctcccccac ctgctccagc acgtcctcgg tgacctggcc gaggaacagt
     8881 tccaggacgc cgatggtgtc cccgcggttg gtgacggggg cgagcacccg ctgcccgtgg
     8941 ccgttgccct cctcggctgt acgtaccagc ttctgggtgc gcaggacctc gtcgtagacg
     9001 ctgctgccgg ccaggggcac ctgttccgcg cggtgctctc ccgcctcgcc cttctcgttc
     9061 acccgcagca ggcgccgtcc cacgacgtcc acgaacagga acgagacgta gcgcgcgccg
     9121 aaccggtcgc gcagattgcg tgccacgatg tcgagagacc cgaccggggc ggcttgctcc
     9181 gccgccgcca gtacctcggc cagtccgatc cggtcccgcg tcacatcagc ctccttggat
     9241 tacggtcctc cttccccggg atgcggcggc catcaccccg gagtgatccg ggcgcgcata
     9301 cgcctccggg ccgcggtccg gacaccacag ccggaagccg aaggctcggc accccggggc
     9361 cggaaggccc ggagttccgg ggtcggtgcc cgcagccccg ggatcggtgg ccggggtccg
     9421 ggtggggccg ccgggccggg acggcggtcc accgcgtcct ttcccggacc gtacacgtcc
     9481 gggcacgggc cggtttccga gcgacccggg gcgatccgga accgccggcc ccgaccggat
     9541 cgagccggac cgcgctgtgc ggctttccgc tccggctgta ccggccaagg acccggaacg
     9601 cgggccggcg gccggaaaac gggaatcccg caccttccgg aatgtcccgt gcgcccttcg
     9661 gaatgtccgg cgccgcgcct gaatctacgc gtccggatcc gtgtgacggc caatggtgat
     9721 ggcacgtgtg tacggcccct tcgagaacgt cccaggtgag ggaccgaacg catatgcgcg
     9781 gtgaacatga agagcagaac ggcggggcgt ccgggcttcg cgcgccccga cgtgcgcgct
     9841 gaatgcgctc tgccgaccgg tgccggcggt ggcttacctt cacatcgcag gacgaaaacc
     9901 ggtcaaccta ccactccgca aaggagctgg aggggaacac cgtacgtact gcattcgtcc
     9961 ggggaatggc ctgtcgctga cttgggggag cgttatggac atgcgctacg aagcgttttc
    10021 gtacgccgac aaggtgttct acgactcgcc ggtccgctgg gcggccatgg aggagttcgc
    10081 agcggtcggc gagccgttac ccgccggctg gctgagctcc tcgagagagg tgtgggtggg
    10141 ccgtcggccc gccgacgtcg aactgcccga ccaggggtgg aagatccacg tgtccgcctg
    10201 tatggacaac gcggagcaca tcctggccgt cgtcggcgcg tactgcgtcg agcggcgtgt
    10261 ggcctacaag ttcctgcgca gcccggcgct cgtgcagacc cagaacgcga agtacgcctc
    10321 ccgcgggtcg agcggcaagt tcatgaccct ctaccccgtc gacgaacccg aactcgaacg
    10381 gtgtctcacc gagctggacg aggcgctcgc cggcctgcgc gggccgtaca tcctcagcga
    10441 cctgcgctgg cgcaacggac cgctgtacct gcgctacggc gggttcaccg aacagttctg
    10501 ccgctcggag acgggtgagc tcgtcctcgc cctgcgcgag ccgtcgggca ggctccgccc
    10561 ggacgtacgg cgcgcggtgt tcgaggtacc cgactgggct cccgtgccgg ccgtcctggc
    10621 ccaggcgctg gccgaccggg ccgccacgag cagagccgag ttcccctaca cggtggagag
    10681 agccctgcac ttctccaacg gcggcggcat ctacatgggc cgtcccgtcg ggggcggcga
    10741 cgaggtggtc ctcaaggagg cgcgcccgga cgccggtctc gaccagcgcg gcgacgacgc
    10801 cgtgctcaga ctcggcagag aacacgacat cctgcgccga ctggagggca tacccgccgt
    10861 accccgcgcg ctcgactacc tcacggcctg ggaacaccac ttcctggtgc aggagtacgt
    10921 gcccggcgag accctgaaca gatggttcgg ccggcgctac cccctggtcc accccgaccc
    10981 cggccgggac acgatcgacc gctaccggga agaggcgctg accgtcctcg ccggcatcga
    11041 ggagggcctg agcgccatcc acgcccgcgg tgtcgtcttc ggagacctgc acccgcgcaa
    11101 cctgatcgtc cggccggacg gcagagtctg cttcgtcgac ttcgaactcg cctcgcccgt
    11161 cgacgcgttc gtcagacccg cgctcggcgc cgcgggcttc gcggcccctc ccgacctgca
    11221 cggcctcgcg atcgaccggt acgcgctcga cgccctgcgg ctgtggatct tcatgccact
    11281 cctccagctg acctcgctgg acccggggaa gcgggacgag ctggtcgcgg cggccaccag
    11341 acgcttcggg atacccgccg acgcggtcgg cggccggccc gacgcgccac cgggggcgac
    11401 cgcaccgccc gcaccggccc acgcaccacc gtccggaccg acggcctccc ggccggccgg
    11461 acgggaggcg ccggccggcc tgttcagcgg cgaccgcgcg gactggccgg ccctgcggga
    11521 ctccctggcc gccgcgatcg acgccagcgc cacccccgag cgcaccgacc gactcttccc
    11581 cggagacccc agccagttca cccacgacgg actcggcctc gcctacggcg cggcgggcgt
    11641 gctctgggcc ctgcacaccg tgggcgccca ggtccggccc ggccacgtcg aatggctcga
    11701 ggaggccgtc gcacgcgaac cctgccgccc cggcctctac accggtgccc acggagtggc
    11761 cttcgcgctg gaccgcctcg gccgcgtccg gcaggcccac aacctcctgg accggctcct
    11821 gaaggatccc ctggacggcc aggggagcga cctggccggc ggactgcccg gcatcggact
    11881 gaccctgctg cacttcgccg acaccacggc cgacgcctcc ctgcacgccg tcgcgctcga
    11941 tgtcgccgac cggctcgccg cccgcctgaa accggacgcc gccaccgcgg gccccgcccc
    12001 cggcaggcgc ccagggctcc tgcacggccc ctccggagcg gcgctgttct tcctcgccct
    12061 ccacgacagc accggtgact ccgtgctgct ggacctcgcc gaacaggccc tcgacctgga
    12121 cctggcccga tgcgtcctcg gcgaggacgg aaccctccag gtggacgacg gcagccgtgt
    12181 cctgccctat ctggagtccg gcagcgccgg catcgccgcc gccctccacg ccctcctgcg
    12241 ccaccgcccc gaccccgaca ggcaacgcag cctcgatcag atccggggcg ccgccgagcc
    12301 cgagttcatc gtccagtccg gactcttcaa cggacgggcc ggcctgatcc tcctgctgca
    12361 cctgctccag gacgggaccg gagcccacgc cccggtcgtc cgacggcaca tccggcgcct
    12421 ggtctggcac ctcgtcccct acgagggaca cgcggccttc cccggcgaac agctcctgcg
    12481 gctgtccatg gacctcgcga ccggctcggc gggcgtcctg ctcgccctcg gctcggccct
    12541 cgcggacacc ccggcgctgc ccttctggaa cggccgacgg gtggcggagc ccgcgcccct
    12601 cccgctcccc gaggcgtcct gacccctacg gcagcgcccc ctgcgacgca caccgtcgca
    12661 cccagagttt ccggcgaccg ccgggaagca ccacaccgaa gtgacaggag aacaccatgt
    12721 ccatcctcag cctgcaggcc ctggagacgc ccgaggagac caccgagtac ctgtcggtcc
    12781 tcagctccct cagcgccgtc aactgcacca acagcaccgt cagcacgctg ctgtgcctgt
    12841 agtcaccgcc gctggacccc ggccgtccga ccgccccact ctcggatgac ctggtgaaca
    12901 gagccggccc gggctgaggg acagcccggg ccggcgtttc tcgtgccgcc ccgcgaaccg
    12961 cccgccccac tcccgcagga gcttccgtat gggacaggac caccgacctc agccgcagcg
    13021 gagcggggct ggatcgcgta cggctccttc caccttcgca catgagacac cgtcaccggg
    13081 aagccgcccg ccgggcgtcg gcgcccgctg gtggtggccc accgtcctcg ccctgtcggt
    13141 gacggggagc tcggccgcag cgctgctgct gcccggcgtc ctcgccaccg ccgtcgacag
    13201 ggcgctgtcc ggcggcgcca ccaccggggg agccctgccg ctcgccgccg tcctcgccct
    13261 gctcaccgcg gccgagaccc tcgcgcagta cgcgggtccg cgcaccaccg cggaggcgac
    13321 cgcgcggctg cgcgccgccc tcgtccggca cctcatggcc accggtctct ctcccgaccg
    13381 gcggacgacg accggcgacc tcgtcgcccg gctgaccgcg agcgccgccg aggccggact
    13441 gagcgtccag gcggccgtct acgccgtcgc ccaactcgcc atggcggcgg gctcggtggt
    13501 cgccctcggg ctgctcgccc cggaactcgc cgccgccttc ctcgtcaccg cccccgcggg
    13561 ctggctgctg ctccgccgcc agctgcggcg caccgtgcgg cgcggtgagg gctaccagga
    13621 ggcccaggcc gccgtggccg cccggctgct ggacgccctg gccggccgcc ggaccatcgc
    13681 cgccgccgga accgtcgacc gtgagatcga acgcgtcctc ggacccgtac cggagctgtc
    13741 ccggcacgga cgcgccctgt gggacagcca gcgccgcgtc gcgtggtcca ccggactgct
    13801 cgcccccgcc acacagatca ccgtgatcgc cgtcgccggg tacgagctct ccaccggcac
    13861 cctcggcgcc ggtgacctcg tggccgcgct cggctacgcc acgctggggc tcggcggctt
    13921 cggcgccgcg cagagcttcc tcgaccacgc ccgcgcccgc gccggacacc gccgggtcca
    13981 ggaggtcctc gcccggcccc ggcagccgcc cggcctgcgc cgcctgccgc cgggccccgg
    14041 acgcgtcgag ctgcgcgggg tcaccgtgcg ccggtcggac gccaccgtgc tcgacgcact
    14101 ggacctgacc ctgcccgccg gacggtgtgt cgccctggtg ggccgctccg gcgcggccac
    14161 ctcactgctg gcggcggtgg ccggcgggct cgtgacaccg gagcggggca ccgtgctgct
    14221 cgacggtgtg ccgacggacg agatccggcc cggtgacctc cgcgccgccg tcgcctacgc
    14281 cttcgcggac ccggagctga cgggcgccac cgtgttcgac gccctggccg tcgccgccga
    14341 gccgctcccc gcggaccggg tccgcgcggc cgcgcgcgcc gcccaggccg acaccttcgt
    14401 ccgacggctg cccgccgggt accggacccc cgtccgcgac gcgcccctct cgggaggcca
    14461 gcggcagcgc ctcgggctcg cccgcgccct cgcgcgcgac ggccggctgc tcgtcctcga
    14521 cgacgcgacg tcgagcctgg actcggccac cgaggccgcg gtgctgcgcg cgctggacga
    14581 cacccacggc ggccggaccc gcctggtggt gacccgccgt acggcgacgg ccgcccgcgc
    14641 cgacctcgtg gcctggctcc acgagggccg catcaggaag gtcgccccgc acgacgaact
    14701 gtggcgcgtc cccgcctacc ggcggatgtt cctcggcacc gacgacacca ccgacgcccc
    14761 cgacaccgag gacgtgatcc ccgcggaggc ccccgagcgc tgaacccggc cccgggggac
    14821 ggagacgacc gccgagagac cgagaagacg agaggacggc acccatggcg gaccgcaccg
    14881 cccgcccgcc ccaccgcgcc gcgcgccacc ggaccccgcc tggcccccgt acgccccaag
    14941 gcacagcgcc gcacggcaca ccggcccgcg ggaccgcgta ccggaccgcc cggtccctcg
    15001 cctcggccaa cggcactgcc ctgcgcctga tccgcgacag cctcgcggcc cgccgtgccg
    15061 ccgccctccg gctgacctgg tggaccctgc tctccgccgc acccgccctc gtgtccggca
    15121 aggccctcgc cctcgccgtg gaccagggat ttctggcggg ccgtccccgc acggctgccc
    15181 tcggactggg cctgttcgcc gtgtgcaccc tcgggggtgc ctgggcgagc cggcagacct
    15241 atccgtggct cgccgagatc gtggagccga agcgggaccg gctgctgcgg gacgtcgtca
    15301 ccggcaccct gcaccgtgcg gtggctccgg ggcccgaccg gggcgacgac ggtgccgccg
    15361 tcgccgtcgc ccgcctcacc cggcaggtgg aggccgtccg ggacgcgctc gccggccagc
    15421 tcatgctgct gtggcagttc gtcctgacgg tcgtcgccgt cgtcgcgggc accgccgtcg
    15481 tcgccccggc cgccgttgcc ctggtcgccg ccccgctgct cgtggcgctc gccctcttcg
    15541 ccctcctggc acccgcgagc gtccgccggc agcgcgaggc gttcgacgcg gaggagaagc
    15601 tggccgcccg cacggtggag acgctcacgg cactgcgcga catcgtcgcc tgcggggccc
    15661 acgaccacgc ccggcgcgag gccctcgacg ccgtggggca ccacctgcgg acctcccggg
    15721 ccctcgcctc cgtgtcggcg ctgcgccgcc tcatcgtggc cctcggcgcg cacagccccc
    15781 tgctgctcgt cgtcctcgcc gcgcccggac tgcacgcccg cgggacgacc gccggcgcga
    15841 tcgtgggcgt gctcggctat gtcctggcga ccctggaacc ggcgatccgc ctgctggtgc
    15901 agggcctcgg cgcgtcctgg ctgcggctgg ccgtcgccgc cgagcgactc gccgaggccg
    15961 cgcgcctccc ggaccccctc ccggaccccg accccggcct gcggcccgcg gacggctcgg
    16021 caaagctgcg cggtgtcacc ttcgcgtacg gcccgcgggc cgagcccgtc ctcgacgggc
    16081 tggacctgtc cctcgcggac ggcgaacacc tggtggtcgt cggcccgtcc ggcatcggca
    16141 agtccaccct ggccgacgtc ctgaccggga tgctctcccc gtgccgcggg caggtcgtcc
    16201 tcggcggtgt gcccctcgac cgcgtcgccg gggccgaacg ggcgcgcgcc cgcgtcctgt
    16261 tgccgcagac cccctacgtg ttcgcgggca ccctgcgcga gaacctctgc tatctcgccc
    16321 ccggcacccc ggaccgggtc ctcgccgagg cggtgacgga actcgggatg accgacctgg
    16381 tggaacggct gggcggtgtg gacggccacg tcggtccggc ggggctgtcc ctgggggagc
    16441 gcgaactcgt ggccctggcc cgcgcctacc tgtcggacgc cgggctggtc gtcctcgacg
    16501 aggccaccgg tcatctggac gcggcggccg aacagcaggt cgaggaggcg ttccgccggc
    16561 ggcccggcac ggtcgtcacc atcgcccacc ggatgaacgc ggcccgccgg gccgaccgcg
    16621 tgctgctcct ggacgggagc cgtccacgcc tcggcacgca ccgggcactg ctcgacgacg
    16681 tccccttcta ccgcgatctg atggggcact gggacaccgg tgcggccggg gcgggccgca
    16741 ccggtgccga ccgtgcgggg tgacggactc aggagcccgg acgcagcatc agatcgctca
    16801 tcgtcgcgtc ccgcggcaga tccagcgccg tgaccacggc ggccgccacc gacgccgggc
    16861 tcatgtgggc gtccgggtcg taggggagac cgaactgctc gtgcagacgg acctgcatcg
    16921 gggtgtccgt ctcgccggga tacacggtgg tgacccggac gccgtgcgcg tactcctccg
    16981 cccgcaggga ctcggccagt gccttcagac cgaacttgga cgccgcgtag gcgctcagcc
    17041 gcggcggtgc gtgcacgccc gcgcccgagt tcacgaagac gacgtgcccc cggcccttgc
    17101 gcagcgcggg cagcagcaga cccgtcagct cggccggggc gatcaggttc accgcgagcg
    17161 tgtcctgcca gacccgtgcg cccagctcac cgacccggcc cgactcgacc accccggcca
    17221 cgtgcagcag tgagtcgagc cgcgcgggta actcctgtgc ctccaaccgg ggccgcacgg
    17281 agcccggttc ggacagatcg gcgacgaggg tacggctccc cgggaaccgg gcgcgcaggt
    17341 ccgcggcccg tgcctcgtcg cgggccagca gccacaactc ctgtccgcgg gacgtgaaca
    17401 gcgtggccac cgccgcgccg ataccggatc cggcacctgt gatgaggtga actcccatga
    17461 cgcgatacat gccccgtgcg cgcgccgcac ccccgctccg ccggggagcc gagggcgctc
    17521 accgggggcg cacggaggcg gggccgtcgg ggacggctgt caccgcgggg gcgtgccggt
    17581 gtcgtcgtcc ggtctcagcc ggacctcgac cagacgggcg aggccggaga ccgccaggac
    17641 cggttggagc agcggggtgg cgacgatctc gagccgctcg gcatgggcga acagcacgtt
    17701 gaggccggcg ctgtcgaggt actccacgcc ggtcaggtcg acgacgagcg gcccccgcac
    17761 gtcgtcgatc gcgtcggcga gcgtggtgct gttgctcatg tcgatctcgc ccgcgacggt
    17821 gaggaggctt ccgccggcgg aggtccgtcc gtgcgtgagg gtcagctgag tgggcattac
    17881 gcgatcctcg tgtgcatctc gacggtggtg cccgagggcc cgggggtgat ggtcacttcg
    17941 tgcgccagcg ccttcatgat gcccaggccc cggccgcggt ggggcgtgtc ggccgggttg
    18001 ccgggcttcc agctcccgct gtccgccacc gtcacccgca cggtgtcgga ggaggtctcg
    18061 gcggacagcc ggatgatccc ttcgtggaag gcccggtggc cgtgctccac ggcgttggcg
    18121 caggcctcgc ccgcggcgat gagcacgtcc tgcgcggtgc gccggggcag ctcgcaccgg
    18181 gccagccact cgcgcagcgc gtgccgcgcg ccggcgagct gccccgactc cgccgggaag
    18241 gcgaactgca aggggccggg gtgccggtac agcaggaggg cgacgtcgtc gtcgtagccg
    18301 ttcgcggggg ccagttcggc catgagccgg tcggccagtt cccgcgcgcc gaggtcccgg
    18361 cccgcgccca tgacctcacc ggcctggtcg atgcccacgt ccagcggctg ccgccgtcgc
    18421 tcgacgagac cgtcggtgta gaccagcagg gaggaccgcg ccgggatcgg gcacacgtgc
    18481 tcgggacggc cgaggtcggg gcggacggcc agggggagcg cgtgcccggc ttcgaggcgg
    18541 cgggtgctgc cgtcggggag ggcgagcacg ccgggcgggt ggccggcgct ggagtaggtc
    18601 aggtccccgg tccgcgggtc gaggacaccg cagaacacgg tggtgcacat ggcgccgggg
    18661 atgccgcggg cgaagtggtc gagggccgag agcgtgcggg ccgggctggg gtcctggagg
    18721 aacagggcgc ggcaggcgct gcgcagctgg cccatcacgg tggcggcctg gagaccgcgt
    18781 ccgacgcagt cgccgacgac gatgccgatc cggccgtccg gcagctcgac tacgtcgtac
    18841 cagtcgccgc cgacctccag cggaggagtg gcgggctcgt agcgcgcggc gaatccctcg
    18901 ggcagccgtg aggggccgag gatggcgcgt tgcagggtga gggcggtctc gcgctgctgg
    18961 tcgatctggt gggcgcgggt gagcgcctgg gccagatgac cggcgaggag cgcgaggagc
    19021 agttcgtcct cggggctgaa gcgtcgtccc gggcccagct cgatccacag cgccatgggg
    19081 ccgtcggggt gctccaggag gacacccgct ccggtcgtct cgtggaccgc ggtgagcagg
    19141 ggctggttgc ggaggtcgcc gatggtgcgc cgccgctcgg ccgggatgtc ctgccaggtc
    19201 agtgggcggg tcgcggtcag gcgcggcgga ccgtccgcga acaccgccga caggacgtgc
    19261 tcggcgtgcc acagttcccg cagctgttcc agggacgccg tgagcgcttc gtccaggccg
    19321 gtcgcctcgg cgaggcgggt gctcagcgag gcgagggcgc tctcgcgctg gacggcgtgg
    19381 cgttcggccg tgacgtcccg gaaggtgccg acgatcatgc ggcggccgct gtcggggtcg
    19441 cgggcgtcgt tgaaggcggc gctgacgtac agccggtgcc cgttgcggtg gacgaggggc
    19501 agggtgtggt tgccgtgtcc gtgcgtcagc aggtgggcga aggcgtcggc cacctgccgg
    19561 tgcgcctcgg gatcggtgcc ggcgtccggc caccacgggt gggcgcggga gtagggcagc
    19621 ccctcggtgc cgtgcccgag catctgggtg aacgcggcgt tgatctccag gacggtaccg
    19681 gtgtcgtcca tgacgaggag ggcttcctgg agcgagtcca cgagcgcggc gcgccagcgc
    19741 acgtggtggg tgcgcagccg ggccagttcc acgttggcgc gcacccgggc cagcagttcg
    19801 gccgcggcga agggcttgac caggtagtcg tccgcgcccg ccgacaggcc ctcgatggac
    19861 gcctcctgtc ccgcccgggc ggagagcagc aggacgggta ccgaggcggt ccgggtgtcc
    19921 gagcgcaggg ccccgacgag ggccaggccg tccatcagcg gcatcatgac gtcgctgacg
    19981 atgaggtccg gggtgcgggc gcgggccgcc gcgagggccg cgaggccgtc gctcaccgcg
    20041 tccgcccggt agccggcctc ggagaggatg cggaccaggt actcgcgcat gtcggcgttg
    20101 tcgtcggcga ccaggatccg ggcgcgttcc gccggcgggg aaccggcggg cggtgtcgag
    20161 gggtcgtggg cgctcttgtc ccggacggcg gttccggtgc cggcgggcag ccagcgcagt
    20221 gcttcctgga cgtagggcac ggcggcggac gacgcgggcc gggaccggga cggctcgcgg
    20281 accgcgtcgg cgggcaggtg ggcggagccg aagggcagcc ggacggtgaa gcgtgtgccg
    20341 aggccgggag tgctctcggc cgagatggtc ccgccgtgca gcacgaccag ctcccggacg
    20401 agggcgaggc cgatgccgct gccttcgtgg gagcgggcgc ggactccgct gatgcggtgg
    20461 aagcgttcga acagacgcgg catctcgtcc gcggcgatac cgacgcccgt gtcggtgacg
    20521 gtcaccaccg cccggtcgtc ctcctcccgg acggtgacgt gcagggagcc ctcgaaggtg
    20581 aatttgaggg cgttgctgag caggttgagc atcaccttct cccacatgtc ccggtcgacg
    20641 tggaccggac ggtcgagcgg cgggcagtcg acgaccaggt cgaggcccgc ccggtccacc
    20701 gccgaccgga agacgctggc gagctcggcg gtcagcgcgg ccaggtccac cggctcgtag
    20761 gacgcctgca tccggcccgc ctcgatgcgg gagaagtcca gcagggtgtt gaccagcttg
    20821 cccaggcgca gcgcgttgcg gtggatcgcc gccagctcct gcccgatctg cccgtcggcg
    20881 tccgcgaggc gcttctggag ttcctcgacg ggccccgaga tcagggcgag gggggtgcgg
    20941 aactcatggc tgatgttgga gaagaacgtc gtcttcgccc ggtcgagttc ggcgagctcc
    21001 tccgcccgcc gctgctgggc ccggtagccg cgggccgtcc cgatcccggc ggcgaggtat
    21061 ccggcgacca gctcgacgaa accccggtac tcctcgtcca gctcccgata cctgttcagc
    21121 gcggcgacga ggaagccgta gggggcggct cccggttgca ccagcggtac caccagggcc
    21181 tggacggggg gttcggtcca ggcgcctgaa ggcaggcccg cggcgagacg ggggtcgagc
    21241 tcggtctgca cggtcgcgcc gtccgcgagg gccgccaccg gccacggggc gccggggtcg
    21301 tcgggcgaca ggaactccgg ggccgccgga tggccggccg gcatgccggt ggtgcaggcc
    21361 aggtgcgcgc cgtcgtcgtc gaggaggtag gtgagcgtga acggcaggtc ggcgaggttg
    21421 tgttcgagct gacggccgag gaaggcgagc gtctcggtct ccgtgcggat gacactgggg
    21481 tcggagccca gatcgcgcag ggtcgccatc cggcgtgcgc cgatgacacg ctcggtgtcc
    21541 tcgctgacca cgcacagcat gcccaccacg gcgccggcgt cctcgcgcag cgggctgtag
    21601 gagaacgtgt ggtacgtctc ctcgcggtac ccggaccgtt ccaggaacag ctggagaccc
    21661 tcgtcccagg tggcctcgcc ggtggacagg acccggtcga cccgcggggc gacggcgggc
    21721 cagatctccg accagacctc ggcggcgggg agccccagcg cccaggggta cttgcggccc
    21781 agcgtgttgt ggcggtaggc ggcgttgcac aggaaggtga ggtcggggcc ccaggccatc
    21841 cacatggaga agcgcgagga cagcaggatg cggaccgctg tccgcaggct ctgcggccag
    21901 tcggcgggcg gcccgagcgg tgtggccgcc cagtccacgg cggccaggtc accaccgatc
    21961 tcggggtcgg cggcgaagac gtcggaccag tccgcgccgt ccgcgtcgtt cccgccgctg
    22021 tccgcatgtg ccaccgggta cctgcttctc gttcgtgagc ggtgcgcgtg ccctccgtgg
    22081 cccgcgagga tgaagccgtg ctgcttcctc tgccgatcct tttgtcccgg acggcgcggt
    22141 tctcacctgg gggaccggga agattattcc gtgtgatcgc cggatcgggg cggaacccgg
    22201 cgaacagccg tcccgacccg gccggccggc gagggccggg acccggcgca cggggcctcc
    22261 cggacgacgc gcctcggacg acgctccgct ctcgggcgcc cgtggtgctc aggcgcccac
    22321 ggtgccgtcg atcccctcgc ggaggaagtc cgcgtgcccg ttgtggcggc cgtactccag
    22381 gaggacgtgg atcatcacca tccgcaggga caccttctcc tcccagcggg gctggtaccc
    22441 ggccaggtcg agggactcgg cggcccgctc gacccggcgc gagttctcca cctcggcctc
    22501 ccaggcggtg aacgcctcgg ccctcgtcga ctcgctcgcg tcgtaggccg cctggaagtc
    22561 gatctcgtcg gaccagacca tgggcgcgtc atggtcctcg aacacccggc ggaaccaggc
    22621 ac
//
