LOCUS       NZ_BMSI01000005        21092 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence05, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000005
VERSION     NZ_BMSI01000005.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 447467)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 26624
            Orig. end                         :: 47716
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21092
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21092
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21092
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11092](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11092
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    411..424
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(955..1737)
                     /locus_tag="IE189_RS14365"
                     /old_locus_tag="GCM10010496_29330"
     CDS             complement(955..1737)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069223.1"
                     /locus_tag="IE189_RS14365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29330"
                     /product="TIM barrel protein"
                     /protein_id="WP_189921515.1"
                     /transl_table=11
                     /translation="MYTLAVCAETVFQELPIEERARRLHEAGFQVEIWDWTRHDLDALA
                     RTPADFVSMTGYISGSLTDEGGAAELLRTAEESLKAAEHLGCARLNLHGTGLDGRGLPV
                     VPVRGEPTEEMWAAARRTLTRVAELGESAGVVFTLENLNTAVDHPGVPFARAADTFALV
                     AAVDRPGLRMNLDLYHAQIGEGNLIELVRAAHRAGLIGEIQVADVPGRHEPGTGEINYP
                     AVARALVDLGYEGTVALEGRPSADTESALARFRSAFTV"
     misc_feature    1848..1864
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.63"
                     /tool="antismash"
     gene            2194..3381
                     /locus_tag="IE189_RS14370"
                     /old_locus_tag="GCM10010496_29340"
     CDS             2194..3381
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042398 - cellular modified amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1165: carboxylate-amine ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006375745.1"
                     /locus_tag="IE189_RS14370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29340"
                     /product="glutamate--cysteine ligase"
                     /protein_id="WP_189921517.1"
                     /transl_table=11
                     /translation="MSVRIGVEEEFHVLEVESGLLVPRAEPLLRRLPRRTFTTELHQST
                     VESNSGVHASLDGLYADLAATRRQLDAAASSLGLAAVAAGTAPLAPADSAHPTADDRYH
                     RMVEDYRTIADEQLICGAQVHVDVPDRDTAVRVMCEVSPWLPVLLALSASSPFWQGSDT
                     GYASWRTVLWQRWPTAGPVGCFAGADEYDATVRDLVGAGIISDPGMIYYDLRPSAHLQT
                     LELRICDSCPRAETVVLVAGLFRALVTEACERLRTDGVPRCEGRHEWLRGASWRAARSG
                     LEGRLVDPDTHQEVPAGQVVRKLLTRLRPALEAHGDLETVRHLAEEALADGSAAHRIRR
                     VAQEEDLLACVDMLIAETRGERAALRATGTRPRKLYPAGLTGHPSPVSARPLTPS"
     misc_feature    complement(2214..2228)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.45"
                     /tool="antismash"
     misc_feature    2214..2228
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.73"
                     /tool="antismash"
     misc_feature    3473..3487
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.46"
                     /tool="antismash"
     gene            3480..5264
                     /locus_tag="IE189_RS14375"
                     /old_locus_tag="GCM10010496_29350"
     CDS             3480..5264
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03104"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120204.1"
                     /locus_tag="IE189_RS14375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29350"
                     /product="N-acetylglutaminylglutamine amidotransferase"
                     /protein_id="WP_189921518.1"
                     /sec_met_domain="TIGR03104 (E-value: 1.1e-288, bitscore:
                     952.9, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="GATase_7 (E-value: 3e-43, bitscore: 141.4,
                     seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 4.4e-87, bitscore:
                     287.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGLSGEIRFDGDRPDLAAVERMNERLAARGPDGRGTWSRGAVAL
                     GHRRLKIIDLSDLGAQPMTDPRAGITGVFNGCVYNYKELREELRGLGHRFVSTSDTEVV
                     LKAYQQWGTACVERFLGMFAFALVEHRSGRLVLGRDRLGIKPLYLARTPGRLRFASSLP
                     ALLAAGDVDTSLDPVAVHQYLSWHATVAAPRTVLNGVRKLPPATVRIVEPDGTHRDHRY
                     WQPSYTRRPEFADMDAEDWRDALQEALRTAVRRRMVSDVQVGVLLSGGLDSSLIVALLA
                     QEGQRDLMTFSVGFESEGGEDGDEFRYSDLVAREFGTDHRRLMVPSDQVSTALDGAVEA
                     MSEPMTSHDVVAFYLLSEQVSKEVKVVQSGQGADEVLAGYHWYPRLAEAARADAAERYA
                     DTYFDRPHADLARILEPGMLPHDDVSGRYVRAHMAAPGAETALDASLRLDTHVMLVDDP
                     VKRVDNMTMAWGLEARVPFLDHELVELAAACPPGLKLADGGKGVLKAAGRRLLPREVVD
                     RPKGYFPVPAIRHMAGPVLKRVREALEAPEARRRGLFRESYVSELLEAPDEHRTKRGAN
                     ALWQVALLEIWLQTHGIS"
     gene            5237..7492
                     /locus_tag="IE189_RS14380"
                     /old_locus_tag="GCM10010496_29360"
     CDS             5237..7492
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823319.1"
                     /locus_tag="IE189_RS14380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29360"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_189921519.1"
                     /sec_met_domain="PF00561 (E-value: 1.5e-06, bitscore: 22.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.7e-43, bitscore:
                     143.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASDARHLVTGEPDTATAPPGASSLPPSVAARPGADGALVAPPST
                     GTRPADGHEGAAAPAPAPVALPEASGPRDAVTRLRSHGCWYPSAGADGTEAAFICDRGG
                     VPQLWAGPVDGDEVHLLDSLPDPVKEVSWSPDGRWIAYTTAPGGGEHSRVLCVRPDGSG
                     RRVLAGADPGHTAHLGCWAHDGSAVAVTLAAPETRAPADGAGPTDTTLPANWAGRDGRA
                     TLLGGTPYDTAPAGGTMTAATAMTAAGPTAAAPPAVPAVRTGGGLSAYLIDPDGLASPV
                     LLATETHAATLRVCDISRDGRLVLMRRGPRGRREAVVRRTADSATTCTVPVADGDPWIG
                     RFSPDGRTLWLRSDAEREYAALLAVTLDPDGRPLGRSVAVERPDSDLDLLAWSQDGRTA
                     ALSWNESGASRLELVDTSPAGRTPYDPLPTTPVPLPHEVVTRVTAAGPRGLLAALSGSQ
                     RRPGVWSAFGSVSLLRTPWSSRDEDATGPGRPPVRPVLLRLTARDGLSLSGWYYRAPGR
                     PAGEPAPCVIHLHGGPEEQERPVFSPLYHELTGRGLDVFAPDVRGSSGHGRSFVDADLG
                     AGRFAALDDVADCAAHAVAEGPADPTRLAVMGRSYGGYLTFASLVHHPDLFRTGVAVCG
                     MSDFATFFAGTEPWLAESAAHKYGHPERDRDLLRALSPMTRIDALRVPLLAVHGEHDTN
                     VPPGESEQFVRAARERGIPARMLTLRDEGHDFLRADNRRLFRRAAADWLQRFLTGRS"
     gene            7635..8552
                     /locus_tag="IE189_RS14385"
                     /old_locus_tag="GCM10010496_29370"
     CDS             7635..8552
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379611.1"
                     /locus_tag="IE189_RS14385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29370"
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_189921520.1"
                     /transl_table=11
                     /translation="MSTSLPHSRTGQNRALTLLDRLEREPRADNLIDAISSGVRSLPLG
                     RGRDVLHGRWLGHPVHPVMVQVPIGSWTSAAVLDLLPGRSREAGLLIGIGLAAAGPAAL
                     TGAVDWAELHHEQQRVGLVHALANTAAVGLYSASLVCRVRGRTAAGRALGFLGLTVAGA
                     GGMLGGHLAYRQAAGANHAEDVPHVVGEGWHRVGDVADFPAGRPVRRVVDDVPVVVVRE
                     AGGTVHALAERCSHLSGPLSEGTVTDGCVECPWHGSVFRLSDGWNVRGPATAPQPAFDT
                     RIVDGHVEVSLRPPEPEAHQAHDR"
     gene            8664..8849
                     /locus_tag="IE189_RS14390"
                     /old_locus_tag="GCM10010496_29380"
     CDS             8664..8849
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018765.4"
                     /locus_tag="IE189_RS14390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29380"
                     /product="DUF1360 domain-containing protein"
                     /protein_id="WP_189921521.1"
                     /transl_table=11
                     /translation="MTCPFCTGVWMVSSLTAGQLPWPRATRTAMGALTAPAGADALQPA
                     YAALVDRTTGADDEGT"
     gene            complement(8909..9766)
                     /locus_tag="IE189_RS14395"
                     /old_locus_tag="GCM10010496_29390"
     CDS             complement(8909..9766)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523062.1"
                     /locus_tag="IE189_RS14395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29390"
                     /product="phosphodiesterase"
                     /protein_id="WP_229901244.1"
                     /transl_table=11
                     /translation="MSRAEVRESAHSVAAAYGGHPADTPSAGVRRRKSPGSRRAGPVET
                     AFRLLAASRRAPALHPRGLTCTAALEVVDDDGGPWGAPWLDVPGIYAATVRFSRAAGLP
                     GAVPDGLGLALRVERADGTGVLLDLLLTTCGRGRLTRHLPRPRADALGGPYSSLLAYRI
                     GGRHRLVAAFPHRTRQASVPAAPGGLRDALATGPLVFELCAETSARTWRPFAVLTVDAA
                     LSVPADRTLDFDPYAHSAHGFRPGGALAAIRRAAYRGSRAGRRARPTTRPADTEAPALL
                     GPTS"
     gene            10001..11092
                     /locus_tag="IE189_RS14400"
                     /old_locus_tag="GCM10010496_29400"
     CDS             10001..11092
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146377.1"
                     /locus_tag="IE189_RS14400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29400"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_189921522.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.1e-41, bitscore:
                     137.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTAALVEQVQARLAGHERRFAALFEEYFRTLPARIGAPEFSRF
                     TPDCLGLLRDLSLRGGKRLRMVLLHEAARLVTDEPVPGLDEAALSVELFQTHALVHDDI
                     IDDSPLRRGGPSTYYAYRERFPGQPRAALGLALLAGDLALALSLTVLLESDAPPEVRRA
                     MVEVQTRASLDTSVGQIIDMERDFTALPGEEVLHQVADFKTARYSVLAPMRLGLLAAGG
                     KPELHDESLRRYARLAGISGQMRDDYLDLFGEAEVMGKPTGTDLADGRRNYLVRAVLTA
                     ADDSGRAVVEAALGDAAARTPETVAAVRDIARRCGAEAELRADMRHYAERAAAEAAGWR
                     SRWRPEAVAFFEHLPLWNVQRAL"
     gene            complement(11132..15502)
                     /locus_tag="IE189_RS14405"
                     /old_locus_tag="GCM10010496_29410"
     CDS             complement(11132..15502)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF044287.1"
                     /locus_tag="IE189_RS14405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29410"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_189921523.1"
                     /transl_table=11
                     /translation="MTPHHDPTPPSDGTPAGAASLTRSVARVLTGDDRTAGTAFLADRD
                     TIVTCAHVVEAAGGAPGGQVRLEFPHLPGAPRTAARVQEAGWRSPDTQDVAVLRLEEPP
                     AGSGPLPLGSAEGCRGRRLRSFGFPARSPDGGRYGFCTTGDLLPGDDTALLQLTDANGL
                     TSGFSGAPVVDESTGLVVGMVTAITPQDSYLRGLDIAYATPTRTLRAVWPQLTESRISP
                     YRGLEPFTEEHAGYFHGRGAAVEEALAVLERQRRAVLLLGPSGAGKSSLVRAGLLPALA
                     EGRLPGSDRWLPVTARPGQDLLGELEAAGLPGAATEGMARAVRRRLAAEHPAARLLLVI
                     DQFEELLTGTAADATAPDEASADVLRQLVAVIESDSAVSLVLVLRDDCFARLATAAPEL
                     LKAVTPGLLNVRASLDVPELRAVVTEPARAAGGRLEEGLAERIVSDVLAADPGATARRT
                     ASATLLPALQLTLSRLWEDRRDGRLTHGAYQRLGGVAGSLTAWCDQAVRGLTPDLRLVA
                     ERILTALVRPAEETHAVPATRCQVPLDHLRALAAGPAADRAESGRDSDRDFDLVLGLLL
                     ERRIITTRVAPGAGRDPARVRAELVHDALIRDWGTLRDWVAADREFQSWLHRTAERRAR
                     FVDARRQNAGEAGVPDPGDLLDGTDLTAGLEWAAQRGLPDGIADFVAASAGRRRAVARR
                     ARRIRVLLVCVLALAVIASGLFLRQRGAAAEQARVSAALDLVKKAEELRVTDPRLALRM
                     GLAAYRLDEEDPTVRASLLETLTTSGHTATLDGLGTVPTALAVSPDGLTLGVGGGDGSL
                     RFWDISRPEQPTLIGKFAGEAGSDAVGALAWRPDGRFLASMNSRTLTLWEAGPRTDPEQ
                     LGSATAFDAPVTAAEWSADGHRLAVADPVSTSLLDIHAEPGEVVTLRRRARIRHGGDPS
                     ERSDRLALSADGGLLITADGADSVQLWDTRGPRPRKLGTALPLPRELYGVTSVALSPDG
                     GTLAIGTPSAHVSVWNVQDPSRPKELQDTTASVDVGLFSPVTTVEFVAAGVLACAGDDG
                     RVQLVRLDTLPFQRTDMPLVHGAAVRTMAADVSHHLLVTGGADGRVILWNTADRDRPRP
                     LRPPLPGHATGSVSGELSAAGNLLASSANDGRTLLWDVERPAKPTSLTAVAAPGSALSP
                     DADLLASAGGERPTDVVLRSTAGGRVRGPGGPLRGHRSVPRAFGWSPDGSLLATGDFDG
                     EVILWDTTDPARVARRAELTQQAGLRLVTFAGSARTLLTVGTDGRARFWDVPAGSGGPT
                     QISSTDIGQLGSDRSSFALSAHGDLLVVGNSTAVLSLWDVSDRRRPRLLSRIATDQDGP
                     VGAVAVSPDASVLAAGIGIGTLLFWDLTDPARPRRMGPARYHRLPMPVAMTFLPDGRTL
                     ATQSITQVELWDLSPALSARSDLAHRACARLAGEGLSESAWKKYAHGTEYRESC"
     gene            complement(15499..15843)
                     /locus_tag="IE189_RS14410"
                     /old_locus_tag="GCM10010496_29420"
     CDS             complement(15499..15843)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114967.1"
                     /locus_tag="IE189_RS14410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29420"
                     /product="CU044_2847 family protein"
                     /protein_id="WP_189921524.1"
                     /transl_table=11
                     /translation="MQGVVSVPLADGGTIRFEATPEHDGPVRVGRFGDAVRELPQTLQE
                     SLVPVGDAARAVLEQLRRAGPDEIEVEFGVTLSAEAGAVITKGTGAVHLKVRAAWSSTG
                     ASARSGDDRT"
     misc_feature    complement(15828..15842)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.04"
                     /tool="antismash"
     gene            complement(15982..17163)
                     /locus_tag="IE189_RS14415"
                     /old_locus_tag="GCM10010496_29430"
     CDS             complement(15982..17163)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971741.1"
                     /locus_tag="IE189_RS14415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29430"
                     /product="spore photoproduct lyase family protein"
                     /protein_id="WP_189921526.1"
                     /transl_table=11
                     /translation="MRHPSTTSDDDSDALFGLDALGPGPAGPDTRGRPSFRDSDTARRL
                     LPVREIHAEPAAAASPRGRQIIARFPEARVVEVASHWRIPGLHGNEGNIARWVRVKGET
                     LVLGERKSPRTRPNGRSADWIAPGASNGCAMACAYCYVPRRKGYANPVTVFTNIDRIIG
                     HIGRHIARQGPKTEPNQCDPEAWVYDIGENGDCSVDALICDNTADLVHAFRQWPTAKAS
                     FATKFVNPDLLALDPRGRTRVRFSVMPPEDSRLLDVRTSPVAERIAAAADFLDAGYEVH
                     FNLSPVVVRPGWEEAWGELLDRLDDVLPARVKRQAAAEVIMLTHNRELHEVNLGWHPRA
                     EEVLWRPDLQESKVSENGALNVRYAGAAKARAVERLRAMVAARAPWLTVRYAF"
     gene            complement(17262..17696)
                     /locus_tag="IE189_RS14420"
                     /old_locus_tag="GCM10010496_29440"
     CDS             complement(17262..17696)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827636.1"
                     /locus_tag="IE189_RS14420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29440"
                     /product="ATP-binding protein"
                     /protein_id="WP_189921528.1"
                     /transl_table=11
                     /translation="MAKDSSLRAVGWARSLPVSSGVKTARDWTRDHLSTLSWSRTDPEL
                     VDSVLLAVSELVTNAHVHAGSAAQLILTWDEECLHVTVHDASPRLPEPRNPGESALGGR
                     GLLLVDALADRWEAYRCPRGKNVTVCFQADGDHVPPSVAG"
     gene            complement(17759..20050)
                     /locus_tag="IE189_RS14425"
                     /old_locus_tag="GCM10010496_29450"
     CDS             complement(17759..20050)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007492396.1"
                     /locus_tag="IE189_RS14425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29450"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_189921530.1"
                     /transl_table=11
                     /translation="MRATLRWAHSDLRTHRGEALFLVLATFGVVVSLLLATALFGYATN
                     PWERVFTQSRGAHVWIHAGASARTAGLAGLDGVESVAGPYPTAATTVSSRGARASVEIR
                     GTDGRPAVGRPLIASGRWLDPAAPDGVVLESSLARALLAGPGDVLTLPGGARPLTVLGV
                     ADSPEPRFRQGERPGLVWAPPSAVPAGGEQGQVIGLRLTDPADTDYAVQRAVTVLGAGA
                     VREVSTWQQARAEAQGDDRLLGQILGLFGLGALVAAGLAVHGAIGTRIRGHLRDISVLK
                     AIGFTPGQVTRLFLLQHAAYALAGALAAAALTEAAGGRLPGRLGDAVGVWQGLPGHAAT
                     LVGIPAGVVLFIGATTALAAWRAGRVPPVPLPRTAAPAGGRLPGPLRRALGWRVPPALV
                     LGWHRTFTRRPRSLATIVRLALPLTLIVVAMSAWTTIERFHSAPERMGLAAALTVRADA
                     GSGDAATRALLARGPGVAAVYPGVEVAALVPGQTATIALRGLGTPADPYPSTLAEGRPA
                     LGPDEAVAGQGLLDLLDVRVGSWVRMTVGGRPQILHIVGRSIEPENAGRVISTTLDTLR
                     ENDPELRPTLYQVRLRDGADPRHVAAALSASAGRGELDVHVVTNPADGLSPLRGVVVGL
                     LGVLALIGLVDLLTAIGGTVRESERDLLALKAIGLSPRQITAITVTATGCTVLASVAVA
                     LAAGLPLSHWLIDAQGRSSGIGAGIAQVPSPLALTAFGAAALLGAMALAALPAARASRR
                     RLADTLSAVG"
     gene            complement(20054..20803)
                     /locus_tag="IE189_RS14430"
                     /old_locus_tag="GCM10010496_29460"
     CDS             complement(20054..20803)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127368.1"
                     /locus_tag="IE189_RS14430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_29460"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189921532.1"
                     /transl_table=11
                     /translation="MKDAPVPALRAEGLVKTHHGEGAPAHAVRGVDLSVRRGEFVAVTG
                     PSGAGKSTLLHLLAGLQRPDSGRVWLDGTCTDGYGEAQWAVARRRRIGVVFQFFNLVSN
                     LSVADNVELPALLAGVSPKRARAEREELLAELGLAGKERSMPGELSGGEQQRVALARAL
                     VNHPPLLLADEPAGSLDSKGTREVTRLLSRFHQRGQTILLVTHDARMASTADRVISFFD
                     GRIADDAELSGTPSPAKGISAVLELRD"
ORIGIN
        1 gagcgcctcg cagcggtcgg cgagcagggt ctcgaccgca cgccgttccc cgcgcgcggc
       61 ggtcaccgcg ctcaacgcga cctggtaacc ggccggttcg gcggcggcgt agatgccctc
      121 cagcagatcg gcgtggaagg gatgctggag ggcgaactgc acgccgagca ggtgggagcg
      181 gtgactgcgc agcagccgcg cccgggtgtc cgggcggtac cccatctgcc gggccgtctc
      241 gaggacgcgc tcacgggtcg cctggctggc gcccttggtg ccccgcatca cgatggagac
      301 cagcgcggtg gacacaccgg cccgggccgc cacgtcggcg agcgtgggcc gtctaccgtc
      361 ggggaccgcc gggggcactg gcacgctgtc cttcctggtc cgcttcgctg tggacgccga
      421 tcatagttcg ccgcccccgc ggtcccgcgc ccgtccggcg ggccgctgtg ccgcggtgcc
      481 gcgcacaccc ggtcgccgac acccggagcg gacggcgcgc gcgtgggtgt ggtcgggtgc
      541 gcggtctgcc ggacgcggcc cggcggaaga gggatgccgg acgcggtgcg cggtgcgaga
      601 tgtggggtcc cggacgcgat gcagagtccg ccggacgccg gacgccgggc ggccagcgtc
      661 tcgcggtgcg cggtgcgccg gacgcggagt acggtgcgcg gtctgccgga cgccgggcag
      721 gcaccgggcg ccgggcatga cgcggtgcga caccgccgag cgcggtctgc cggacgccgg
      781 ccgggtaccg accgcccagc gtcacgccgg gcaggcgccg ggcgccaggc gtcacgcggt
      841 gcggtccgcc gagcgcggtc cgccgagccc ggtgcgccgc gcgcggagcg cggtgcgcag
      901 tccgccgggc tcacgccagg cgggcaccgg acaccccgcg tccggcgtcc cgtgtcacac
      961 ggtgaacgcg gaccggaagc gggccagggc gctctccgtg tcggcggagg gccggccctc
     1021 cagggcgacg gtgccctcgt agcccaggtc gacgagggcc cgggcgacgg ccgggtagtt
     1081 gatctcgccg gtgcccggtt cgtggcgacc gggtacgtcc gccacctgga tctccccgat
     1141 gagccccgcg cggtgtgccg cgcggaccag ttcgatcagg ttcccctcgc cgatctgggc
     1201 gtggtacaga tccaggttca tgcgcagtcc cggccggtcc acggcggcga ccagggcgaa
     1261 ggtgtcggcg gcccgggcga agggcacgcc gggatgatcg acggcggtgt tgaggttctc
     1321 cagcgtgaac accacgccgg cgctctcgcc gagctccgcg acgcgcgtca gggtgcgccg
     1381 ggcggccgcc cacatctcct cggtcggttc accccgcacc ggcaccacgg gcagcccccg
     1441 gccgtccagc ccggtcccgt ggaggttcag gcgggcgcag cccaggtgct cggcggcctt
     1501 gagcgactcc tcggccgtgc gcagcagctc ggcggcgccg ccctcgtcgg tgagactgcc
     1561 gctgatgtat cccgtcatgg agacgaagtc ggcgggggtc cgggcgagcg cgtcgaggtc
     1621 gtgccgggtc cagtcccaga tctcgacctg gaagccggcc tcgtggagcc gccgggcccg
     1681 ctcctcgatc ggcagctcct ggaagaccgt ctccgcgcag accgccagtg tgtacatcgc
     1741 ggctctccct ttccccgggt cgccccgact agaacgttct acatgccgtg agcagtacgc
     1801 cagtccgccc gccggtctgt caagggaccg ggagccgcgt tgctggaacg ttccagtaga
     1861 acgttccagc ggccgccccg gcgaccggtc gtccgccgcg ctcccgggtc ctcgggggag
     1921 ggggcccgcg ggctccgtga tctgcggagg ggccgacaac gtgcgactct gagggcccgc
     1981 ccacggtcgg ccgccgagcg gcgggagcgg atcgcccgac tctcgcgcgg gtggcgtgag
     2041 gccgctcatc cgagggatgt ccgcgtcaca tgggtcgcgc gggcttacaa atcggcgttc
     2101 tggtgactcg aagatcctca gacgcggccg tgtccgccgg cggggcacct ctccccggcg
     2161 gtcggcggcc gatcatcgcc ccgaggagtg agcgtgagcg ttcgtatcgg agtggaagag
     2221 gagttccacg tcctggaggt ggagagcggg ctgctcgtac cgcgcgccga gccacttctg
     2281 cggcgactcc cgcggcgcac cttcaccacc gaactgcatc agtccaccgt cgagtcgaac
     2341 agcggggtcc acgcctcgct cgacggcctg tacgccgacc tcgccgccac gagacggcag
     2401 ctggacgcgg cggcctcctc cctgggcctc gcggcggtgg ccgccggcac cgcgccgctc
     2461 gcgcccgccg actccgcgca ccccaccgcg gacgaccgct atcaccggat ggtcgaggac
     2521 taccgcacga tcgccgatga acagctcatc tgcggggccc aggtccacgt ggacgtcccc
     2581 gaccgcgaca ccgcggtacg ggtcatgtgc gaggtctcgc cctggctgcc cgtgctgctg
     2641 gcgctctccg ccagctcgcc gttctggcag gggtcggaca ccgggtacgc gagctggcgc
     2701 accgtgctgt ggcagcgctg gcccaccgcg ggcccggtcg gctgcttcgc cggcgcggac
     2761 gagtacgacg ccacggtccg cgacctcgtc ggggccggga tcatcagcga cccggggatg
     2821 atctactacg accttcgccc ctcggcccac ctccagaccc tggaactgcg catctgcgac
     2881 tcctgcccgc gggccgagac ggtggtgctc gtcgccgggc tgttccgcgc cctggtcacc
     2941 gaggcctgcg agcggcttcg cacggacggg gtcccgcgct gcgagggccg gcacgagtgg
     3001 ctgcgcggcg cgtcctggcg ggccgcgcgc tccgggctcg aaggccgact ggtggacccg
     3061 gacacccacc aggaggtgcc cgccggtcag gtggtgcgca agctgctcac ccggctgcgc
     3121 cccgccctgg aggcgcacgg cgacctcgag accgtccggc acctggcgga ggaggcgctc
     3181 gccgacggca gcgcggccca ccgcatccgg cgcgtcgccc aggaggagga cctgctggcc
     3241 tgcgtcgaca tgctgatcgc cgagacccgc ggcgaacgcg ccgccctcag ggcgaccggc
     3301 acccgccccc ggaagctgta cccggccggt ctcaccggcc acccctcacc cgtgtccgca
     3361 cggccgctga cccccagctg acgcgccgtg cgcacccatg acccccgcaa ccgcgccgag
     3421 gaccgggcac ccgcgcccag gtcaccggcc gacgccgaac gaactggagg cggcacgaca
     3481 tgtgcggtct gagcggtgag atccgcttcg acggtgaccg acccgatctc gcggccgtgg
     3541 aacgcatgaa cgagcggctc gccgcccgcg gccccgacgg acggggaacc tggagccggg
     3601 gggcggtggc actggggcac cgacggctga agatcatcga cctgtcggac ctcggggcgc
     3661 agccgatgac ggacccacgc gccgggatca ccggagtctt caacggttgc gtgtacaact
     3721 acaaggagct gcgtgaagag ctgcgaggcc tgggacaccg gttcgtgtcg acctccgaca
     3781 ccgaggtcgt cctcaaggcc taccagcagt ggggcacggc ctgcgtcgag cgcttcctcg
     3841 gcatgttcgc cttcgccctg gtcgagcacc gctcggggcg gctggtgctc gggcgtgacc
     3901 ggctcggcat caagcccctc tacctggcgc ggaccccggg caggctgcgg ttcgcctcct
     3961 cgctcccggc gctcctcgcc gccggtgacg tggacacctc gctcgacccg gtcgccgtcc
     4021 accagtacct gagctggcac gccacggtcg cggcgccgcg cacggtcctc aacggcgtcc
     4081 gcaagctccc gccggccacc gtccggatcg tcgagccgga cggcacccac cgcgaccacc
     4141 gttactggca gccgtcgtac acccgccggc ccgagttcgc cgacatggac gcggaggact
     4201 ggcgggacgc gttgcaggaa gcgctgcgca ccgccgtccg ccggcggatg gtctccgacg
     4261 tccaggtcgg cgtactgctc tccggcggcc tggactccag tctgatcgtc gccctgctgg
     4321 cccaggaggg gcagcgggac ctgatgacgt tcagcgtggg attcgagtcg gagggcgggg
     4381 aggacggcga tgagttccgg tactccgacc tggttgcccg cgagttcggc accgaccacc
     4441 gccggctgat ggtcccgtcc gaccaagtgt cgacggcgct ggacggcgcc gtcgaggcga
     4501 tgagcgagcc gatgaccagc catgacgtgg tcgccttcta cctgctgtcc gagcaggtgt
     4561 ccaaggaggt caaggtcgtt cagagcggcc agggcgccga cgaggtgctc gccggctacc
     4621 actggtatcc gcggctcgcc gaagccgccc gcgcggacgc ggccgagcgc tacgccgaca
     4681 cctacttcga tcggccgcac gccgacctcg cccggatcct ggagcccggc atgctgcccc
     4741 acgacgacgt ctcgggccgc tacgtgcgcg cccacatggc ggccccgggg gccgagacgg
     4801 cgctggacgc ctcgctgcgc ctggacacgc acgtcatgct cgtcgacgac ccggtcaagc
     4861 gggtcgacaa catgaccatg gcctggggcc tggaggcccg cgtgccgttc ctcgaccacg
     4921 agctggtgga actggccgcc gcctgtccgc ccgggctcaa gctggccgac ggcggcaagg
     4981 gagtgctgaa ggcggccggc cgccggctcc tgccgcggga ggtcgtcgac cgtcccaagg
     5041 gctacttccc ggtccccgcg atcaggcaca tggcgggccc cgtgctgaag cgggtgcgcg
     5101 aggcgctcga agcacccgag gcgaggcgcc gcggcctgtt ccgcgagtcg tacgtgtccg
     5161 agctcctcga ggcgcccgac gagcaccgca ccaaacgggg agcgaacgcg ttgtggcagg
     5221 tagcgttgct ggagatatgg cttcagacgc acggcatctc gtgaccggcg agccggacac
     5281 cgccacggcc ccgcccggtg cgagctccct cccgccgtcc gtggccgccc ggccgggagc
     5341 cgacggcgcg ctcgtcgcac cgccgtccac cgggacgcgg cccgcggacg ggcacgaggg
     5401 cgccgccgca cccgccccgg cgccggtcgc cctgcccgag gcgagcggac cgcgggacgc
     5461 cgtcacccgg ctgcgctcgc acggctgctg gtacccctcc gcgggcgccg acggcaccga
     5521 ggcggccttc atctgcgacc ggggcggggt gccccagctg tgggcggggc ccgtcgacgg
     5581 cgacgaggtg cacctgctgg actccctccc cgaccccgtc aaggaggtgt cctggtcacc
     5641 ggacggccgc tggatcgcct acaccacggc gcccggcggc ggcgagcact cccgcgtact
     5701 gtgcgtacgg cccgacggca gcggccgccg cgtgctcgcc ggggccgacc cgggccacac
     5761 cgcccacctg ggctgctggg cgcacgacgg ctcggccgtc gccgtgacgc tcgccgcccc
     5821 ggagacccgc gcgcccgccg acggcgcggg gcccacggac accaccctgc ccgcgaactg
     5881 ggcgggccgg gacggccggg ccaccctgct gggcggcacc ccgtacgaca ccgcaccggc
     5941 tggcgggacc atgacggccg cgacggccat gaccgcggcc ggccccacgg ccgccgcacc
     6001 ccccgcggta ccggcggtcc ggaccggcgg cggtctgtcg gcctacctga tcgaccccga
     6061 cggtctggcg tcccccgtcc tgctcgccac tgagacgcac gccgccaccc tgcgggtgtg
     6121 cgacatcagc cgcgacggcc ggctcgtgct gatgcgccgg gggccgcgcg gacggcgtga
     6181 ggcggtcgtc cgccgcacgg ccgactcggc gacgacctgc accgtgccgg tcgccgacgg
     6241 cgacccgtgg atcggccggt tctccccgga cgggcgcacg ctgtggctgc gcagcgacgc
     6301 cgaacgcgag tacgcggcgc tcctcgccgt caccctggac cccgacggcc ggcccctggg
     6361 caggtccgtc gccgtggaaa ggcccgacag cgacctcgac ctgctggcgt ggtcgcagga
     6421 cggccgcacc gccgcgctgt cctggaacga aagcggcgcc agccgtctcg aactcgtcga
     6481 cacctccccg gccggccgca ccccgtacga tccgctgccg acgacacccg tgcccctgcc
     6541 ccacgaggtc gtcacccggg tcacggcggc cggcccgcgc ggcctgctgg cggcgctgtc
     6601 gggctcccag cggcggcccg gggtgtggtc cgccttcggc agcgtctcgc tgctgcgcac
     6661 cccctggtcc tcccgggacg aggacgccac cggtcccggc cggccgcccg tgcgcccggt
     6721 cctgctgcgg ctcaccgccc gcgacgggct gtccctgagc ggctggtact accgggcgcc
     6781 cggccggccc gcgggcgagc cggcgccctg cgtcatccac ctgcacgggg gaccggagga
     6841 acaggagcgc ccggtcttca gcccgctcta ccacgagctg accggccgcg gcctggacgt
     6901 gttcgccccc gatgtccgcg gttcctcggg gcacggccgg tcgttcgtcg acgccgacct
     6961 gggcgccggc cgcttcgccg ccctggacga cgtcgcggac tgcgcggcgc acgcggtcgc
     7021 ggagggcccc gccgacccga cccgcctggc ggtcatgggg cgctcgtacg gcggctacct
     7081 caccttcgcc tcgctcgtgc accaccccga cctgttccgt accggtgtcg ccgtctgcgg
     7141 catgtcggac ttcgcgacct ttttcgccgg cacggaaccc tggctcgcgg agtcggccgc
     7201 ccacaagtac ggccaccccg agcgcgaccg cgacctgctg cgcgcgctct caccgatgac
     7261 ccggatcgac gcgctgcgcg tgcccctgct cgccgtccac ggcgaacacg acaccaacgt
     7321 gccgccgggg gagtccgagc agttcgtccg ggcggcacgc gagcgcggca tcccggcccg
     7381 gatgctgacc ctgcgcgacg agggccacga cttcctccgc gcggacaacc ggcgcctgtt
     7441 ccggcgggcc gccgcggact ggctccagcg cttcctcacc ggccggagct gaccccctcc
     7501 tggtcccgga cgccgccgac ccggccctgc ggaccccgag ggtggtccga cgccgacccc
     7561 gccgtgacga ccgccgtcgc cctgcggtcc cggctgcccg tttgccgtat cgcgcgacgg
     7621 ggacccggag gcgcatgagt acctcgcttc cccacagccg gaccgggcag aaccgggccc
     7681 tgacgctcct cgaccgtctg gaacgggagc cgagggcgga caacctgatc gacgcgatca
     7741 gctcgggcgt acggtccctg ccgctcgggc gcggccggga cgtgctgcac ggcagatggc
     7801 tcgggcatcc cgtgcacccg gtgatggtcc aggtgccgat cggcagctgg acctccgccg
     7861 cggtcctcga cctgctcccc ggccgctccc gggaggcggg cctcctgatc gggatcgggc
     7921 tggcggcggc cggacccgcg gcgctcacgg gcgccgtcga ctgggcggag ctgcaccacg
     7981 agcagcagcg cgtgggcctg gtgcacgccc tggccaacac ggcggccgtc ggactgtact
     8041 cggcctcgct ggtgtgccgg gtcaggggac gcacggcggc gggccgggcc ctcgggttcc
     8101 tggggctgac ggtggccggc gcgggaggca tgctgggcgg tcacctggcc taccgccagg
     8161 ccgcgggcgc caaccacgcc gaggacgtcc cgcacgtcgt cggcgagggc tggcaccggg
     8221 tcggcgacgt ggcggacttc ccggccggcc ggcccgtgcg gcgcgtcgtg gacgacgtgc
     8281 cggtcgtggt ggtgcgcgag gcgggcggga cggtccacgc gctggccgag cggtgcagcc
     8341 acctctcggg cccgctgtcc gagggcacgg tcacggacgg gtgcgtcgag tgcccctggc
     8401 acggcagcgt cttcaggctc tccgacggct ggaacgtccg cggcccggcc accgcccccc
     8461 agcccgcctt cgacacccgg atcgtggacg ggcacgtcga ggtgtccctc cgcccgccgg
     8521 agcccgaagc gcaccaggcg cacgaccggt gacggcgtca cgcgctcgcc cggcgagcgg
     8581 gaccggagcg gcccgcaggg cccggccgag ctgcacgagg tggcgcgcga ggaggccggg
     8641 aaggaaaccg tcggcgagag ctgatgacct gcccgttctg caccggcgtg tggatggtgt
     8701 cgagcctgac cgccggacag ctgccctggc cgcgcgccac ccgcaccgcc atgggcgcgc
     8761 tcaccgcccc ggccggggcg gacgcactcc aaccggccta cgcggcactg gtggacagga
     8821 cgaccggcgc cgacgacgaa ggaacgtgac gtccgcggca gccgcgaccg ctcggggccc
     8881 tgcggcgagg gattcgggct ctggcggttc aggaggtcgg gccgaggagc gcgggtgcct
     8941 cggtgtcggc ggggcgtgtc gtgggccgcg cgcggcggcc cgcccgtgag ccccggtagg
     9001 cggcgcggcg gatcgcggcc agggcgccgc ccgggcggaa gccgtgcgcg ctgtgcgcgt
     9061 aggggtcgaa gtccagggtc cggtccgcgg gcacggacag cgcggcgtcc accgtcagca
     9121 cggcgaacgg ccgccacgtc cgggcggagg tctccgcgca cagttcgaag acgagcggcc
     9181 cggtggccag ggcgtcccgc agaccgcccg gggcggcggg tactgacgcc tgccgggtgc
     9241 ggtgcgggaa ggcggccacg agccggtggc gtccgccgat ccggtacgcg agcaggctgg
     9301 agtaggggcc gccgagcgcg tccgcccggg gccggggcag gtgccgggtg agacggccgc
     9361 gcccgcaggt ggtcagcagc aggtccagga ggacgccggt gccgtcggcc cgctcgacgc
     9421 gcagggcaag acccagcccg tcgggcacgg cgccgggcag gcccgccgcc cgggagaagc
     9481 ggaccgtggc ggcgtagatc ccgggtacgt ccagccacgg cgcaccccag ggtccgccgt
     9541 cgtcgtcgac cacctccagg gcggccgtgc aggtcaggcc gcgtggatgc agggccggtg
     9601 cccggcgcga agcggccagc agacggaacg cggtctccac cggtccggcc cgccgcgacc
     9661 ccggcgactt ccgccgtcgt acgcccgcgg acggagtgtc ggcggggtgg ccgccgtacg
     9721 cggcggcgac gctgtgcgcg gactcccgga cttccgccct gctcatccga cctccctcgg
     9781 tagggcgggc cgggtacccc cggagcggga cccctactcc cggccggtga gccggtgcgg
     9841 cgatcggccg tcggcggaca cggagtgcgg ccgtgggcga ggatggcggg cacggggatc
     9901 accgtgatcc gggactgccc ggccccgggc ggagcgcccg caccccggac ccttccgatc
     9961 ttcccgatcc tccagaccct tcgtcccgca ggagaccgtc atgaccgaca ccgccgctct
    10021 cgtcgaacag gtgcaggcgc gcctggccgg acacgagcgc cggttcgccg ccctgttcga
    10081 ggagtacttc cggacgctgc ccgccaggat cggcgcgccg gagttcagca ggttcacgcc
    10141 cgactgcctc ggcctgctgc gggacctgtc cctgcggggc ggcaagcggc tgcggatggt
    10201 gctgctgcac gaggccgcac gcctggtgac cgacgaaccc gtccccggtc tggacgaggc
    10261 ggccctgagc gtagagctgt tccagaccca cgcgctggtc cacgacgaca tcatcgacga
    10321 cagccccctg cgcaggggcg gcccgtccac ctactacgcc taccgcgaga ggttccccgg
    10381 acagccgcgg gccgccctcg gcctggccct gctcgccggt gacctggcgc tcgccctctc
    10441 cctcaccgtc ctgctggagt ccgacgcgcc gcccgaggtg cgccgggcca tggtcgaggt
    10501 gcagacacgg gcgtccctgg acacctccgt gggccagatc atcgacatgg aaagggactt
    10561 cacggcgctg cccggcgaag aggtcctcca tcaggtcgcc gacttcaaga ccgcccgcta
    10621 ctcggtgctg gccccgatgc ggctgggtct gctcgctgcg ggcgggaagc cggagctcca
    10681 cgacgagagc ctgcgccgct acgcacgcct cgccgggatc tccgggcaga tgcgcgacga
    10741 ctacctcgac ctcttcggcg aagcggaggt gatgggcaag ccgaccggga ccgacctcgc
    10801 cgacgggcgg cgcaactacc tggtgcgggc cgtgctgacg gcggcggacg actccgggcg
    10861 ggccgtggtg gaggcggcgc tcggtgacgc cgcggcccgc acccccgaga ccgtcgccgc
    10921 cgtccgtgac atcgcccgcc gctgcggggc ggaggccgaa ctgcgcgcgg acatgcggca
    10981 ctacgcggag cgggccgccg ccgaggcggc gggctggcgg tcacggtggc gtccggaggc
    11041 ggtggccttc ttcgagcacc tgcccctgtg gaacgtgcaa cgggcgctgt gagcccacca
    11101 gagcgatgcg ggacccggcc cgccgtccgc gtcagcagct ctcccggtac tccgttccgt
    11161 gcgcgtactt cttccaggcg gactcggaca atccctcgcc cgcgagtcgg gcgcaggccc
    11221 ggtgcgccag gtcggaccgg gcggacaacg cgggggacag gtcccagagt tcgacctgcg
    11281 tgatgctctg ggtggccagc gtccggccgt cggggaggaa cgtcatggcg acgggcatcg
    11341 gcaggcggtg gtaccgggcg ggccccatcc ggcggggccg ggccgggtcg gtcaggtccc
    11401 agaacagcag ggttccgatc ccgatgccgg cggccagcac ggaggcgtcc ggggagacgg
    11461 cgaccgcgcc caccggaccg tcctggtccg tggcgatccg cgacagcagg cgtggccgac
    11521 gtctgtccga cacgtcccac agggacagga cggcggtgct gttgccgacg acgagcaggt
    11581 cgccgtgggc ggacagggcg aacgacgagc ggtcgctgcc cagttggccg atatccgtgc
    11641 tgctgatctg tgtggggccc ccggacccgg ccgggacgtc ccagaaccgg gctctgccgt
    11701 cggtgcccac ggtgagcagg gtgcgggccg agcccgcgaa ggtcaccagg cgcaggccgg
    11761 cctgctgggt cagttccgcc cgcctggcca cccgcgcggg atcggtggtg tcccagagga
    11821 tcacctcgcc gtcgaagtcg cccgtggcca gcagggatcc gtcgggtgac cagccgaacg
    11881 cccggggcac gctccggtgg ccccgcagcg gaccgcccgg cccgcgcacc ctgccgccgg
    11941 ccgtgctccg cagcaccacg tccgtgggcc gctcgccacc ggcgctcgcc agcaggtccg
    12001 cgtcagggga gagcgcggat ccgggagcgg cgaccgccgt cagggaggtg ggcttcgcgg
    12061 gccgttcgac gtcccacagc agggttctgc cgtcgttggc gctgctggcc agcaggttcc
    12121 cggcggcgct cagttcgccg gacacggagc ccgtggcgtg gccgggcagg ggcgggcgca
    12181 gtggccgggg gcggtcccgg tcggcggtgt tccacaggat gaccctgccg tcggcgccac
    12241 ccgtgaccag gaggtggtgg gagacgtcgg ccgccatggt gcgcaccgcg gcgccgtgga
    12301 cgagcggcat gtcggtgcgc tggaacggca gggtgtccag ccgtacgagc tgtacgcggc
    12361 cgtcgtcgcc cgcgcacgcg aggaccccgg ccgcgacgaa ctccaccgtg gtcacagggc
    12421 tgaagaggcc gacatcgacg gaggccgtcg tgtcctggag ttccttcgga cggctcgggt
    12481 cctggacgtt ccacacggag acgtgggccg agggggtgcc gatcgccagg gtcccgccgt
    12541 ccggcgacaa cgccaccgag gtgaccccgt acaactcccg ggggagcggc aacgccgtcc
    12601 cgagtttgcg tggtcgaggg cctctcgtgt cccacagctg gacggagtcc gctccgtcgg
    12661 cggtgatcag cagacccccg tccgcggaca gggcgagccg gtcgctccgt tccgaagggt
    12721 cgccgccgtg gcggatcctg gcccttcggc ggagggtgac gacctcgccg ggctcggcgt
    12781 ggatgtccag gagggaggtg ctcaccgggt cggccacggc gagccggtgg ccgtcggcgc
    12841 tccactcggc ggccgtcacc ggcgcgtcga acgcggtcgc ggagccgagt tgttcgggat
    12901 cggtacgggg gccggcctcc cagagcgtca gagtccggga gttcatggac gccaggaatc
    12961 tgccgtccgg ccgccaggcg agcgcgccga ccgcgtccga cccggcctcg cccgcgaact
    13021 tcccgatcag cgtgggctgt tcggggcgtg agatgtccca gaaccgcagg gaaccgtcgc
    13081 cgccccccac cccgagcgtg agaccgtcgg gggagacggc gagggcggtc ggcacggtgc
    13141 cgagcccgtc gagcgtggcg gtgtgccccg acgtcgtcag cgtctccagc agactcgcgc
    13201 ggaccgtcgg gtcctcctcg tccagccggt acgccgccag tcccatccgg agggcgagcc
    13261 gggggtcggt gacccgcagc tcctcggcct tcttcaccag gtcgagggcc gccgacacac
    13321 gggcctgctc ggcggcggcc ccccgctgcc gcaggaacag tcccgacgcg atcacggcca
    13381 gcgcgagcac gcagaccagc aggaccctga tccggcgcgc ccggcgggcg acggcacgac
    13441 gtcgtccggc gctcgccgcg acgaagtcgg cgatgccgtc gggcagtcca cgctgcgcgg
    13501 cccattcgag ccccgcggtg agatcggtcc cgtccagcag gtcaccgggg tcggggacac
    13561 cggcctcgcc ggcgttctgc cgcctcgcgt cgacgaagcg ggcccggcgt tcggcggtgc
    13621 ggtgcagcca ggactggaac tcccggtccg cggccaccca gtcgcgcagt gtgccccagt
    13681 cccggatcag ggcgtcgtgg acgagttcgg cgcgcacccg ggccggatca cggccggcgc
    13741 cgggtgccac ccgggtggtg atgatccggc gttcgagcag caggccgagc accaggtcga
    13801 aatcccggtc gctgtcccgg ccgctctccg cgcggtccgc cgccgggccg gccgccagcg
    13861 cccgcagatg gtcgagcggt acctgacacc gggtcgcggg caccgcgtgc gtctcttcgg
    13921 ccgggcgcac cagcgcggtc aggatgcgtt ccgcgacgag ccggaggtcg ggggtgagcc
    13981 cgcgcaccgc ctggtcgcac caggccgtca ggcttccggc gactccgccg aggcgctggt
    14041 aggccccgtg ggtgagtctg ccgtcccggc ggtcctccca gagccggctg agggtgagct
    14101 ggagtgcggg cagcagggtc gccgacgccg tgcggcgggc cgtggcgccg gggtcggccg
    14161 ccagcacgtc ggagacgatc ctttccgcca gcccctcttc cagacggccg cccgcggccc
    14221 gggccggctc ggtgacgacg gcccgcagct ccggtacgtc caaggaggcg cgcacgttca
    14281 gcagaccggg cgtcacggcc ttcaggagct cgggagctgc ggtggccagc cgggcgaagc
    14341 agtcgtcccg caggacgagg accaggctga ccgcgctgtc cgactcgatc accgcgacga
    14401 gctgccgcag gacgtccgcc gacgcctcgt caggagccgt cgcgtccgcg gccgtaccgg
    14461 tgaggagctc ctcgaactgg tcgatgacga ggagcaggcg ggcggcggga tgttccgcgg
    14521 ccagccgccg ccgcaccgcc cgggccatgc cttcggtggc ggcgccgggc agtcccgccg
    14581 cctccagctc accgagcagg tcctgtcccg gcctggccgt cacgggcagc caccggtcgc
    14641 ttccgggcag ccgaccctct gccagcgccg gcagcagacc ggcccgtacg agggaggact
    14701 ttcccgcgcc cgaggggccg agcagcagca cggcccgccg ctgccgctcc agaacggcga
    14761 gggcctcctc cacggcggcc ccccggccgt ggaagtaccc ggcgtgctcc tcggtgaacg
    14821 gttcgagccc ccggtaggga ctgatccggc tctcggtcag ctgcggccag acggcgcgca
    14881 gtgtccgggt cggggtggcg taggcgatgt ccaggccccg caagtaggag tcctgggggg
    14941 tgatcgccgt gaccatcccg acgacgaggc cggtcgactc gtccacgacg ggcgcgccgc
    15001 tgaaacccga ggtgaggccg ttggcgtcgg tcagctggag cagggcggtg tcgtcgcccg
    15061 ggaggagatc accggtcgtg cagaagccgt agcgtccgcc gtcgggcgac cgtgccggaa
    15121 acccgaaaga ccgcaggcga cggccccggc atccttctgc ggatcccagt ggcagcggac
    15181 ccgacccggc gggcggctcc tccagacgca ggacggcgac gtcctgcgtg tcgggcgacc
    15241 gccaccccgc ctcctggaca cgggccgccg tgcggggggc gcccggcagg tgcgggaact
    15301 ccaggcgtac ctgtccaccg ggcgcgccac cggcggcctc gaccacatgg gcgcaggtga
    15361 cgatggtgtc gcggtcggcc aggaacgccg tcccggcggt gcggtcgtcg ccggtcagga
    15421 cgcgtgcgac cgagcgggtc agggaggcgg ccccggcggg cgtgccgtcg gacggcgggg
    15481 tcgggtcgtg gtgcggtgtc acgtcctgtc gtccccgctc cgggcggacg ctcccgtgct
    15541 gctccaggcg gcccgcacct tcaggtgcac ggcgcccgtc cccttggtga tgacggctcc
    15601 ggcctcggcc gacagggtca ccccgaactc gacctcgatc tcgtcgggac cggcccgccg
    15661 caactgctcc agtaccgctc gcgcggcgtc accgaccggt accagcgact cttgcagcgt
    15721 ctgcggcaac tcccgtacgg cgtccccgaa ccggccgacc ctgaccgggc cgtcgtgttc
    15781 gggcgtggcc tcgaaccgga tcgtcccgcc gtccgccagc ggaacgctga caacgccttg
    15841 catgaagccc cccatgtccg gcgcccccgt ggtgaccgga tgagcggcga cgttagcggg
    15901 gcggacaccg gcgcacccgg ggttcggccc acacggtgcc gtgattcata cgaaacggtg
    15961 agcattcaaa tgcgcgtcca ctcagaacgc gtaccggacg gtcagccacg gtgccctggc
    16021 ggcgaccatc gcgcgcagcc gctccaccgc gcgtgccttg gcggcgccgg cgtagcggac
    16081 gttcagcgcg ccgttctcgg agaccttcga ctcctggagg tccgggcgcc acaggacctc
    16141 ctcggcgcgc ggatgccagc ccaggttgac ctcgtgcagc tcccggttgt gcgtcagcat
    16201 gatcacctcg gctgcggcct gccgcttcac ccgcgcgggc aggacgtcgt cgagccggtc
    16261 gaggagttcc ccccaggcct cctcccagcc ggggcggacg acgacggggg agaggttgaa
    16321 gtgcacctcg tacccggcgt ccaggaagtc agcggcggcg gcgatccgct cggcgaccgg
    16381 tgaggtgcgc acgtccagca gccgcgagtc ctcgggaggc atcaccgaga agcggacgcg
    16441 ggtgcggccg cgcgggtcca gggccagcag gtcggggttg acgaacttgg tcgcgaagga
    16501 cgccttggcc gtcggccact gccggaaggc gtgcacgagg tcggcggtgt tgtcgcagat
    16561 cagcgcgtcg accgagcagt cgccgttctc gccgatgtcg tacacccagg cctcggggtc
    16621 gcactggttg ggctcggtct tggggccctg ccgggcgatg tgccgtccga tgtggccgat
    16681 gatccggtcg atgttggtga acaccgtgac ggggttggcg taccccttgc ggcggggcac
    16741 gtagcagtag gcgcaggcca tcgcgcagcc gttggaggcg cccggtgcga tccagtccgc
    16801 ggaccgtccg ttggggcggg tccgcggcga cttccgctca ccgaggacga gcgtctcccc
    16861 cttgacccgc acccagcgcg cgatgttgcc ctcgttgccg tgcagtcccg ggatgcgcca
    16921 gtgcgatgcg acctcgacca cgcgcgcctc ggggaaccgg gcgatgatct gccggccgcg
    16981 gggggaggcc gcggccgcgg gttcggcgtg gatctcccgc accggcagca gccgccgggc
    17041 ggtgtcggag tcgcggaacg acggccggcc gcgggtgtcc gggcctgcgg gcccggggcc
    17101 gagggcgtcg agcccgaaca gggcgtcgga gtcgtcgtcc gaggtggtgg acgggtggcg
    17161 catgagcgtt ccggtcgggt cggagtggca ctgaacggac caaacgcgga ggaatccgct
    17221 ccgcccactc tacggccagc accgcacgtg cgaaggcggg ctcatcccgc cacggacggc
    17281 gggacatggt cgccgtccgc ctggaagcag acggtgacgt tcttgccgcg cgggcagcgg
    17341 taggcctccc agcggtcggc gagggcgtcg accagcagca gcccccgccc gccgagcgcg
    17401 gactcgcccg ggttgcgcgg ctcgggcagc cggggcgagg cgtcgtgcac cgtcacgtgc
    17461 aggcactcct cgtcccaggt gaggatcagc tgggccgcgc tgcccgcgtg cacgtgggcg
    17521 ttggtgacca gttccgacac ggcgagcagc accgagtcca ccagctccgg gtcggtccgc
    17581 gaccagctga gcgtggacag atggtcgcgg gtccagtccc tcgcggtctt caccccgctg
    17641 ctcaccggca aagaccgggc ccatcccaca gccctcagcg atgagtcctt cgccactgtc
    17701 gtcactcctt cggccgacca cccgggttca tgtcccgtgt gccccggatc ggccggctct
    17761 agcccaccgc gctcagggtg tccgcgaggc ggcgccggga ggcgcgggcc gcgggcagcg
    17821 cggcgagcgc catggcgccc agcagcgcgg ccgcgccgaa cgcggtcagc gcgagcggcg
    17881 acggaacctg cgcgatgccc gccccgatgc cgctcgagcg gccctgggcg tcgatcagcc
    17941 agtgggagag cggcagaccc gcggccagcg ccacggcgac ggaggcgagg acggtgcacc
    18001 cggtggccgt gacggtgatc gccgtgatct gccgtggtga caggccgatc gccttgaggg
    18061 ccagcagatc gcgctcgctc tcgcggaccg tgccgccgat ggcggtcagc aggtcgacca
    18121 gcccgatcag cgccaggacg ccgagcaggc cgaccacgac gccgcgcaag ggcgacaggc
    18181 cgtcggcggg gttcgtcacg acgtgcacgt ccagctcacc gcggcccgca gatgcgctca
    18241 gtgcggcggc gacgtgtcgc ggatccgcgc cgtcgcgcaa ccgcacctgg tacagcgtcg
    18301 gccgcagctc cgggtcgttc tcgcggagcg tgtcgagcgt cgtcgagatg acccggccgg
    18361 cgttctccgg ctcgatgctg cggcccacga tgtgcaggat ctgcggccgc ccgcccacgg
    18421 tcatgcgcac ccagctgccg acccggacgt ccagcaggtc cagcagaccc tgccccgcca
    18481 ccgcctcgtc cggaccgagc gcgggccgcc cctcggccag cgtgctgggg tacgggtccg
    18541 cgggggtgcc gaggccgcgc agggcgatcg tcgccgtctg acccggcacc agggccgcca
    18601 cctcgacgcc cggatagacc gcggccaccc cgggaccgcg cgccagcagg gcccgtgtcg
    18661 cggcgtcgcc cgagccggcg tcggcccgga ccgtgagcgc ggcggccagc cccatccgct
    18721 ccggcgcgct gtggaaccgc tcgatcgtcg tccacgcgct catagccacc acgatcagcg
    18781 tcagcggcag cgcgaggcgc acgatcgtgg ccagggagcg cgggcgccgg gtgaacgtcc
    18841 ggtgccagcc gaggaccagc gcgggcggca cccgccaacc gagcgcgcgc cgcaacgggc
    18901 caggcagccg tccgcccgcg ggagcggcgg tcctcggcag cggcacggga ggcacgcgcc
    18961 ccgcccgcca ggctgcgagt gcggtggtcg cgccgatgaa cagcaccacc cccgccggta
    19021 tccccacgag ggtcgccgcg tgcccgggca gcccctgcca caccccgacc gcgtccccga
    19081 gccggcccgg cagccggccg cccgccgcct cggtgagggc cgcggcggcc agcgcgcccg
    19141 ccagcgcgta ggcggcgtgt tgcagcagga acagccgcgt gacctggccc ggtgtgaatc
    19201 cgatggcctt gaggacggag atgtcccgca gatgcccccg gatccgggtg ccgatggcac
    19261 cgtgcacggc gagcccggcg gcgacgaggg cgcccagtcc gaacagcccc agtatctggc
    19321 ccagcagccg gtcgtcgccc tgcgcctcgg cccgtgcctg ctgccaggtg gagacctcgc
    19381 gcacggcccc ggcgcccagc acggtcaccg cgcgctggac ggcgtagtcg gtgtcggcgg
    19441 ggtcggtcag ccgcagcccg atcacctggc cctgctcgcc gccggcgggc accgcggacg
    19501 gcggtgccca gaccaggccc ggccgctcac cctggcggaa gcgcggctcg gggctgtcgg
    19561 cgacaccgag gacggtcagc ggacgtgcgc cgccgggcag ggtgaggacg tcaccgggcc
    19621 cggccagcag ggcccgggcg aggctgctct ccagcaccac gccgtccggc gccgccgggt
    19681 cgagccagcg gccggaggcg atcaggggac gtccgacggc gggccgcccg tcggttcccc
    19741 ggatctccac ggaggcgcgg gctccgcgcg aggagaccgt ggtcgcggcg gtgggatagg
    19801 ggcccgcgac ggactcgacg ccgtccagcc cggcgagccc ggccgtccgc gcggaggcac
    19861 cggcgtggat ccagacatgc gcgccccggg actgggtgaa gacccgctcc caggggttcg
    19921 tcgcatagcc gaacagcgcc gtcgccagga gcagcgacac caccaccccg aaggtggcga
    19981 gtaccaggaa gagcgcttcg ccgcgatggg tccgcaggtc ggagtgcgcc cagcgcaacg
    20041 tggcccgcac ggttcagtcc ctcagctcga gcaccgcgga tatccccttg gccggcgacg
    20101 gcgtgccgct cagttccgcg tcgtcggcga tccggccgtc gaagaaactg atcacgcggt
    20161 ccgcggtgct cgccatccgg gcgtcatggg tgaccagcag gatggtctgg ccgcgctggt
    20221 ggaaccggga cagcaggcgg gtcacctcgc gggtgccctt gctgtccagg ctgcccgcgg
    20281 gctcgtccgc cagcagcagg ggcggatggt tgaccagggc ccgggccagc gccacccgct
    20341 gctgctcgcc gccggacagc tcaccgggca tgctgcgctc cttgcccgcg agccccagct
    20401 cggccagcaa ctcctcccgc tccgcccgcg cccgcttggg ggagaccccg gccagcagtg
    20461 cgggcagctc gacgttgtcg gcgaccgaga ggttggagac caggttgaag aactggaaga
    20521 cgacgccgat acggcgccgg cgtgccacgg cccactgggc ttcgccgtag ccgtcggtgc
    20581 aggtgccgtc cagccagacg cggccgctgt cggggcgctg gagaccggcg agcaggtgca
    20641 gcagcgtgga cttcccggcg ccggacggac cggtgacggc cacgaactcg ccccgccgca
    20701 cggacaggtc caccccgcgc acggcgtggg ccggagcccc ctcgccgtgg tgggtcttca
    20761 cgagcccttc ggcccgcagc gcaggaacgg gggcgtcctt cactccggtt cctccagttc
    20821 ctcctggcag cgttccaacc agtcgaggtc ggcctgtaga tgcagcatgg cgccctccac
    20881 gagcagccgg gccacccggt tgtcgcggtg ctcgcccgtg acgagcttgg acagggtgcg
    20941 catggtgttc agatagtggc gtcgttgctt gttgatcagg gcgatccggt cggcgagacc
    21001 ggtctgcgga gcgagtgcga gcttcatgaa gaactcgtcg cgcagccgcg gttcgtccgc
    21061 cgtctcctcg taccaggcgc gcagcgcttc cc
//
