LOCUS       NZ_BMSI01000002        21041 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000002
VERSION     NZ_BMSI01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 655051)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 368278
            Orig. end                         :: 389319
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21041
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21041
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21041
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11041](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11041)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    199..214
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.52"
                     /tool="antismash"
     gene            complement(428..868)
                     /locus_tag="IE189_RS07615"
                     /old_locus_tag="GCM10010496_15420"
     CDS             complement(428..868)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013006173.1"
                     /locus_tag="IE189_RS07615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15420"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_189919079.1"
                     /transl_table=11
                     /translation="MDAIDERIITELTRNARISHAELGQRVRLSRNAVRQRVERLERQG
                     HIGGYTIVRPSCGPDRETVAAHVLVYREDRMRGAEVLAALKRIPEVVSCDVLSGQFDLL
                     VSVEADSLERVQGIWEQMAQMPGVRDTVTALALSRVVSRPRR"
     gene            complement(985..1776)
                     /locus_tag="IE189_RS07620"
                     /old_locus_tag="GCM10010496_15430"
     CDS             complement(985..1776)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016812 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in cyclic amides
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378103.1"
                     /locus_tag="IE189_RS07620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15430"
                     /product="cyclase family protein"
                     /protein_id="WP_189919080.1"
                     /transl_table=11
                     /translation="MTPDTARTAAPATTTEPPLWALHRELTAGTVRTDLTHAFHPGQPH
                     FPAFPDEKREMPFDMSRGDGFNVHLYTIVGQWGTHVDPPVHFVAGGRTLDEIPVDEMIL
                     PLVVLDITERVATDPDAVPTLADVAAWESRHGRVPEGAFVALRTGWGRRWPDPAAMANR
                     DAAGVSHCPGWSAEVLRHLFEEAGVTAIGHEQTDTDPGLATSAGDFGLEDYVLRRDRWQ
                     IELMANLDRVPEAGALIVATWAKPLGGSGFPARVFALHHEN"
     gene            complement(1773..2471)
                     /locus_tag="IE189_RS07625"
                     /old_locus_tag="GCM10010496_15440"
     CDS             complement(1773..2471)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378139.1"
                     /locus_tag="IE189_RS07625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15440"
                     /product="HAD hydrolase-like protein"
                     /protein_id="WP_189919081.1"
                     /sec_met_domain="HAD_2 (E-value: 2.1e-24, bitscore: 81.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAPTCVLLDLDGTLVDSAPGVTASAAEALRSVGAAVPDAATLRS
                     FVGPPMHDTFRRVAGLDEAAARAALTVYRAAYARDGATAAALYDGVPELLDALAARGLP
                     MGVATSKVQDQAELMVRRFGLGSRLPTVCGVREEAGRTTKREVIRECLARLRSGGADVR
                     RPLMVGDRAYDVESAAAEGIPAVHVRWGYGGPAESAHAVASVARPAELVDWIDLLDHAG
                     NGAEMKDEHA"
     gene            complement(2468..3913)
                     /locus_tag="IE189_RS07630"
                     /old_locus_tag="GCM10010496_15450"
     CDS             complement(2468..3913)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015171 - amino acid transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0003333 - amino acid transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378152.1"
                     /locus_tag="IE189_RS07630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15450"
                     /product="amino acid permease"
                     /protein_id="WP_189919082.1"
                     /transl_table=11
                     /translation="MSVSAVPDSAPADADTVPGPPGDGLRRTMRSRHLVMIAMGGVIGS
                     GLFLSSGFTVSQAGPLGAVLAYVVGAFVVWLVMACLGELAVAYPVSGAFHVYASRSIGP
                     ATGFATAWLYWLTWAVALGSEFTACGLLMQRWFPGVGVWVWCVVFAAVVFGVNAFSARV
                     FGETEYWFSLVKVIAVVALIVFGGAALAGFHPLAEGGSHPVLLENFHTSDGLFPHGFSG
                     VLVTVLAAFYAFSGSELIGVAAGETENPAEAVPKALRVTVVRLLVFFVGAITVIAATIP
                     YDQVGLDESPFVTVFSSIGFPYAADAMNFVIITALLSAGNSGLYSCARMLFSLAEEKQA
                     PQALRRLSRRGIPLTALSLSMLGGLASLVSSVAAPETVYLVLVSIAGFAAVGVWMSIAA
                     AQFFHRRAFVRAGGDPGALPYRTPLYPVVPVLAFVLCLASLVGIALDPAQATALYFGVP
                     FVAGCYLYHWLRHGRRRTAGVVA"
     gene            complement(4090..4563)
                     /locus_tag="IE189_RS07635"
                     /old_locus_tag="GCM10010496_15460"
     CDS             complement(4090..4563)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378124.1"
                     /locus_tag="IE189_RS07635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15460"
                     /product="hypothetical protein"
                     /protein_id="WP_229901124.1"
                     /transl_table=11
                     /translation="MATTTITPEPTAQDREGAPAPVRRRTVRTIKVYWPVATATLTACA
                     KGDLDALRADESFAALLRIVETSPELGDFGVYGDVFEVSLGAEGFSVRPGARPSLGSVG
                     GRFLSATLAVTTYVDAATDDDTLARLLDRLADAHPWEVPVIELSAPLDLVSRA"
     gene            4748..5515
                     /locus_tag="IE189_RS07640"
                     /old_locus_tag="GCM10010496_15470"
     CDS             4748..5515
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014177671.1"
                     /locus_tag="IE189_RS07640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15470"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_189919083.1"
                     /transl_table=11
                     /translation="MDSSVTKGLDALSALARGPAGGRPPGSAASVSELARGLGRDRSQV
                     SRMLTAMAAEGFVGRDEGSGGFAPHWRLYTAARDLTAHRLRTDGLTALEGMAAETGESC
                     YLGVLAGDATVTIAERVPAGSRQLGSWIGRPYPAYCSDCGQALLSDADDDEVAAVFART
                     EFVRHGPNTPTGPEDFLRRLAGTRRRGYSIVDEEAEPGLYSVAVPVRDFTGEVVAAVQV
                     VGPRRRLEPRTQECAAAALRWAGHLETSLRGTT"
     gene            <5710..5835
                     /locus_tag="IE189_RS07645"
                     /pseudo=""
     CDS             <5710..5835
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545939.1"
                     /locus_tag="IE189_RS07645"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="YTAVRASGAEIVHPLQDEEWGVRRFFVRDPGGRVVNVLGHR"
     misc_feature    complement(5928..5937)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.67"
                     /tool="antismash"
     gene            5953..6492
                     /locus_tag="IE189_RS07650"
                     /old_locus_tag="GCM10010496_15480"
     CDS             5953..6492
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516246.1"
                     /locus_tag="IE189_RS07650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15480"
                     /product="transcriptional regulator"
                     /protein_id="WP_189919084.1"
                     /transl_table=11
                     /translation="MPTDDLPETFRVTTDDQLRAVSNLTRHRIMAVLRFEPATITQIAE
                     RVGLAKGSSSYHVRLLERAGLVKVVRTRKVRGVTERYYAMAARAIELPDPGEGGPDVLM
                     RHAVADLEASPVDGERHVRMAHLRLTEEQFAQLGARLEALADEYRELSDPSLPDASLVF
                     ALFHPARRARIEGDAK"
     gene            6489..7775
                     /locus_tag="IE189_RS07655"
                     /old_locus_tag="GCM10010496_15490"
     CDS             6489..7775
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744083.1"
                     /locus_tag="IE189_RS07655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15490"
                     /product="MFS transporter"
                     /protein_id="WP_189919085.1"
                     /transl_table=11
                     /translation="MTQTVGKLPTGFGRLWTAQTVSSLGDGVSHAALPLIALTLTRDPM
                     ALAVVTAAGTLPWLLFGVLGGALVDRWDRRHTMWIADTARAVLLVTPAAAAALDLLSIP
                     LLAAVAFLLGLGGLFFDTAATAYLPDLLGRDPELLERANSRLRGAQTAMSGFAGPPAGS
                     ALLALGRAVPLLTDAVSFLVCALLVRTLPALPRPAPKTREPLLRQARAGASYVFRDRVL
                     LGLALRPAVGNVAFLAVETVLALFAHERLGIDTYGFGLLLTAEATGGLIGAGIASSLGR
                     RLGTGTALTCTAAVEGLAVLGLAAASNPYVAGAALAVCGAGMGATMVLGPSLRQAIVPA
                     HLMGRVASTSRMLAMCAAPVGAFLGGWLAAAHDIRTPLFAAAGLLLTMTAVTASMTGNR
                     RVEAALRAAAPADVREAEESAVGGSTPLR"
     gene            8027..9361
                     /locus_tag="IE189_RS07660"
                     /old_locus_tag="GCM10010496_15500"
     CDS             8027..9361
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330849.1"
                     /locus_tag="IE189_RS07660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15500"
                     /product="MFS transporter"
                     /protein_id="WP_189919086.1"
                     /transl_table=11
                     /translation="MTTADDVPKPIGTLFRIPGFRRYVSADLISATGSAMAPLALAYAV
                     IGQGGGAGSLGVVLATNTVPTIVFLLVGGLFADRLSRSRLLFVGNLLAACAQGALAVTV
                     ATGHATTASIAACGFVSGTAASFIVPAAQGAVAQIVPEEHLQQANALLRLPGNAVKVLG
                     PVVGGVLVAASGAAWALAWDACTFAVAAVLLLGLRLDAPLVTSEGVLRDLRAGWAGFWS
                     RTWLWTYTAAGMILVAAWLAGFQLLGPLVAEEQYAGARDWGLVQAAFTAGLLAGTVVCL
                     RWKPYRLLAVAVVAAGALALPLAALACAVPLALVLVAVVLAGVGLDIAIVAWTTAFQRH
                     VPPAEQGRMSAFNGVGERLAIPVGYLITALAAHSWSTQAVLLTCAGMIAAATVLNLCVP
                     DVYRINRRTDRRPPDDQPSAAQGQGQGQGQGRPGRRRGRGTVEQT"
     gene            9480..9962
                     /locus_tag="IE189_RS07665"
                     /old_locus_tag="GCM10010496_15510"
     CDS             9480..9962
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004994325.1"
                     /locus_tag="IE189_RS07665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15510"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_189919087.1"
                     /transl_table=11
                     /translation="MDTTGIVRRPTAERVRDTTERLAAERDVWVSTAHPDHGPHQVPLW
                     FLWDGRAVWLCTGATSVTVRNVRAEPRVRLALPDTFDVVLLQGEAECSTETEVPAPAAE
                     AFAAKFGWDPRGEEGSFVYVRVVPRTVRAWRGEPELRGRAVMRDGMWLEQPPVPRP"
     gene            complement(10001..11041)
                     /locus_tag="IE189_RS07670"
                     /old_locus_tag="GCM10010496_15520"
     CDS             complement(10001..11041)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981512.1"
                     /locus_tag="IE189_RS07670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15520"
                     /product="terpene cyclase"
                     /protein_id="WP_189919088.1"
                     /sec_met_domain="T1TS (E-value: 1.4e-70, bitscore: 234.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDVDFDLPPATRPGPGLDETRRRNLNWVRGLGLVTDDRSAAWY
                     ASWDMTRLAALGFPHARGRALDLCADAMGFFFVFDDQFDGPLGRDPALVVQVCRRLIDI
                     AHGAAPPADADACTAAFADVRARGIQGADPAWTARTAHEWEYYFAAHAHEAIGRLRGTP
                     ADMETYLLVRRSIAGTDLPLSLGERAAGITVPAAAFHAPELRIMRRTAIDVTLMCNDVY
                     SLEKEEARGDVDNLVLVLEHTRRLTRAEAVAAAVRRVNRNVRRFAELAGRVTALCGRLG
                     LRPHERAAVDTYVEIMAAWMSGYHAWQTETLRYRAAPRIVPASGPGHLAQVLRTRPLDA
                     PSPHAG"
     gene            complement(11055..12035)
                     /locus_tag="IE189_RS07675"
                     /old_locus_tag="GCM10010496_15530"
     CDS             complement(11055..12035)
                     /NRPS_PKS="Domain: PKS_KR (6-182). E-value: 1.1e-13. Score:
                     43.5. Matches aSDomain:
                     nrpspksdomains_IE189_RS07675_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006140504.1"
                     /locus_tag="IE189_RS07675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15530"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_189919089.1"
                     /sec_met_domain="adh_short (E-value: 2.8e-31, bitscore:
                     104.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFEDRVAVVTGAGRGLGREYALFLAARGARVVVNDVGTGIDGCG
                     ESPSPAHAVVEEIRQLGGTAVADVHDVSTTPGARALTRAAVERWGRLDVLVNNAGISIL
                     RPLTELSEDECRRVLDTHVGGTLNMARAVWPHMLASRYGRIVNTCSDALFGDNGLSVYA
                     AGKGGVLGLTTSLAAEGAAHGIKVNAVVPIAATRMSLEALQDDEPMTALLTDLFPARLV
                     ASVVALLAHESVPCTGELLHAAGRRVGRIFLGATEGVLWKEDPTPESIRDRLCEVRETE
                     GFRTPSSLSASMAFSLEQLGAGGAEPLALDLSSPAPGRAEPDTQG"
     aSDomain        complement(11490..12017)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS07675_PKS_KR.1"
                     /evalue="1.10E-13"
                     /label="IE189_RS07675_PKS_KR.1"
                     /locus_tag="IE189_RS07675"
                     /protein_end="182"
                     /protein_start="6"
                     /score="43.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAGRGLGREYALFLAARGARVVVNDVGTGIDGCGESPSPA
                     HAVVEEIRQLGGTAVADVHDVSTTPGARALTRAAVERWGRLDVLVNNAGISILRPLTEL
                     SEDECRRVLDTHVGGTLNMARAVWPHMLASRYGRIVNTCSDALFGDNGLSVYAAGKGGV
                     LGLTTSLAAEGAA"
     CDS_motif       complement(11934..12011)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS07675_0001"
                     /evalue="1.20E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE189_RS07675"
                     /protein_end="34"
                     /protein_start="8"
                     /score="17.9"
                     /tool="antismash"
                     /translation="VVTGAGRGLGREYALFLAARGARVVV"
     gene            12313..12792
                     /locus_tag="IE189_RS07680"
                     /old_locus_tag="GCM10010496_15540"
     CDS             12313..12792
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008736603.1"
                     /locus_tag="IE189_RS07680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15540"
                     /product="hypothetical protein"
                     /protein_id="WP_189919091.1"
                     /transl_table=11
                     /translation="MLLSDHATGVELRLVGYQFPETRGDAYDDNWLVVAATVTTPEGSW
                     SFTDPCLLTDEAREVSVWLRAAASGAVGVTAPDRDGRLWPDTWFVEPVLGFSLAARSDE
                     AAVIRIHLSSEAIPPWRRDDSADIYQYAVDVMVEKEALLHAADHWDRALASFPPR"
     gene            complement(12844..13677)
                     /locus_tag="IE189_RS07685"
                     /old_locus_tag="GCM10010496_15550"
     CDS             complement(12844..13677)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009070459.1"
                     /locus_tag="IE189_RS07685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15550"
                     /product="hypothetical protein"
                     /protein_id="WP_189919093.1"
                     /transl_table=11
                     /translation="MCISTGEAAFSGTIVYCGRQHHPVHGLIHVLGYQNTAVNLADGPN
                     AMLLHLPARQRLTPGNFISAGRTGDVLRRMVDAVAPVAVATDGIAWMSAEPQSVQVFDH
                     DVYTVLLAADPTAVTAALRQVPPHRRPDLDPDLLRFYADHFPDHTIALCCFDNADAQDA
                     KPLLLWYPPLDPDRLTLPALDSHTGAAPDLDAAVSVDHWVLFSTDQAPEGWGEPVDHPG
                     TMRHSLRAFLPATVMGDYYGDEQKLLNGDFTISHQDLLAGDLDRVERRQPRVRRG"
     gene            complement(13720..14154)
                     /locus_tag="IE189_RS07690"
                     /old_locus_tag="GCM10010496_15560"
     CDS             complement(13720..14154)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477122.1"
                     /locus_tag="IE189_RS07690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15560"
                     /product="hypothetical protein"
                     /protein_id="WP_189919094.1"
                     /transl_table=11
                     /translation="MDSELAALSATGASTLVSLLVTDSWSHARELLRRFLSRGDADTSA
                     ITDLEGVRGRLLAARTAGHPCDAHDTVEQWGARVRQLLEVHAASCAELRELVTSLQRLR
                     DEPAQPATVHNSIEGGVQHGPVIQSGRITGLTIHTTHPDD"
     gene            complement(14221..15255)
                     /locus_tag="IE189_RS38930"
                     /old_locus_tag="GCM10010496_15570"
     CDS             complement(14221..15255)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE189_RS38930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010496_15570"
                     /product="hypothetical protein"
                     /protein_id="WP_229901125.1"
                     /transl_table=11
                     /translation="MTTGRKTTTVFLTVLCALLLTILGLVQEWPLWAWAALAVAVAGVP
                     AAAFKIAAVRRGALPADFTNFIPAAPIERREHRVSRVSLPSNWDDYEFLFSATVRWHPL
                     ETHGDDPVLNPAGLAVEAILDRARTLTEQREPGQVSFVQHELSGALGRMRPDRAGHLRV
                     MAENITLTLHEPDQERLNRLAEVRKDEAVWEHQRKYEQSMREYLGADVLKDTGSAVVWW
                     LAKNDNHIERTVADLGLLAQLTSAANDTDIPDRLRGLIAASDEPSTPVGPEQTAPDHFE
                     AFLTGMGLTRGDDKWAMLTKQIADVIRTQDKHETADELLRRYDPPADFATSADDRRDEP
                     EEPA"
     gene            complement(15252..17234)
                     /locus_tag="IE189_RS07705"
                     /old_locus_tag="GCM10010496_15580"
     CDS             complement(15252..17234)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477117.1"
                     /locus_tag="IE189_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15580"
                     /product="hypothetical protein"
                     /protein_id="WP_189919096.1"
                     /transl_table=11
                     /translation="MSETFTTHIEQPGGQVHSGSGDFYSYTVNVGLAEQEATTRSPRRI
                     ADDQLRLLRQQFVDPTGMSTARRVLHGSSTVILSGAPGSGRTAAARVLLYEVQRTAGIF
                     RELLPGEEEGALTGPGLVGAGDRLLLNLAEADITQWAQTRRDLSALRKAVLEQGAHLVV
                     VMPHDGGLESHLQPYRADIARPPAMEVFRRHLRLHRVPYEEFRLPAPALDEFLAEQPPM
                     EEIAHFADRVRRARAAAPDRDGFATWCKNSRAHSAWRKEVADCVATLCAAPQRALLFAT
                     AMFHGAHADLVHQGAALMLTVHDTPQDEMPALEGPDLAQRLTEIGAAARPDGHVRFGKL
                     DYDVAVRAHFWDHMPDLRHRFGIWTAESTELDDPHLSAELRTRLVGRLAEQYVRTGRGL
                     DLALLAEKWSSAPASRVRLAAAVDALACGLRDPRYGRSLRMLVYTWCKDKPLSGNLAHV
                     LLRACTDVIAPTHPDQAVTRLHHLARRERGATPALDALCRLSATSSRLRRLLLDRVTRL
                     SASPTIDARLFLRICDPMALTDPAGAAHPLIDEKGVQDCTVTGWSEAFTRLPQAHWRPY
                     AERWLHAACVVDSHRDRLLFLLVDSAGRNGSTLAALYAAARTVEPAAPGDRASGAATTR
                     LLLQKISTAQGLHPPAAPPSRGTTR"
     gene            complement(17231..17986)
                     /locus_tag="IE189_RS07710"
                     /old_locus_tag="GCM10010496_15590"
     CDS             complement(17231..17986)
                     /GO_function="GO:0003953 - NAD+ nucleosidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477116.1"
                     /locus_tag="IE189_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15590"
                     /product="toll/interleukin-1 receptor domain-containing
                     protein"
                     /protein_id="WP_189919098.1"
                     /transl_table=11
                     /translation="MPDVFINYRTGDGNDIAALIDNELANRFGKDRAFRASHSIPPGSA
                     YPDALLMGVRRSALVLVVIGPDWLNFQSRLHDAEDWVRKEIMEAFDCGVPVVPVLAGRR
                     TERLSKERLPDELARLAELQSVRLDTQNAEADLKRLGDLVAEMVPELYDLEHAEAAPPD
                     PGSVSNSTGTVSGTAVQSRDFAGDLNSTVINGSAGPVHSGRGNIYQNSHHVSGGRHYSG
                     DGMTNIEGDHRGDIRHRFGDTGSSGDDER"
     gene            complement(17999..19297)
                     /locus_tag="IE189_RS07715"
                     /old_locus_tag="GCM10010496_15600"
     CDS             complement(17999..19297)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114973.1"
                     /locus_tag="IE189_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15600"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_189919099.1"
                     /transl_table=11
                     /translation="MPQPSSEFGEELRKRRLDAGLSLTALASAVHYSKAQLSKVERGIK
                     APSRDLARLCDAALHAGGALISLVALTVGDVPKEPAPHGVDEEEWVMQLSPDGSGGFQP
                     VGRRQVVGAGAASLMTWRTGGQIPVSPTGGVGAGMLDASRSLFTHYRRLGQSAEPGILL
                     PGLIAQTHTLRELSAHVDARTRRELLALGSRYAEYVGWLVQETGNEQAALWWTQRAVDL
                     AAAGGDRALAGYALVRRALVTLYQDDAEQTVSLARRAQSDTLPTRIRGLAAQREAQGHA
                     LAGDSDACMRALDRARTLLARQEIDHDTPVIGSMHLPDSVGMVTGWCLFDLGEAGRAAE
                     ELDRQLALVSPDAVRTQVRYGVRRALAYASHGEIDHACDLVAPLLDGVTAVRSATVTID
                     LRRLSRVLARHSTHTAVRRLGPRLAVLSRLPFS"
     misc_feature    19469..19484
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.11"
                     /tool="antismash"
     gene            complement(19677..20525)
                     /locus_tag="IE189_RS07720"
                     /old_locus_tag="GCM10010496_15610"
     CDS             complement(19677..20525)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524838.1"
                     /locus_tag="IE189_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_15610"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_189919100.1"
                     /transl_table=11
                     /translation="METRELRYFVAVAEELHFGRAARRLGIAQPPLSRAIGGLERRLGT
                     LLLERGSRGVSLTDAGAVLLREARAALDAVEAAERRTRRAALAATGRPAVVLAAKAGAS
                     GELLAKLLDAYAAEPGAVTVDVALCGPGEQTRLLHDGRADVALLHRPFDDTAGFDTEEL
                     HSEGQVVILPAGHPLGARPQVRLAEVTGLPDLPLPRWPGPDGTFPDGPGPQVRDHTQLT
                     QLIALGRACAVVPESGRTGLREDLTAVPVLDAAHVTTVIAWPPHSRSTAVAGLVRAATA
                     L"
ORIGIN
        1 ctgccggcgc ggcaggccgg ttcctcggtc atgccgggca aggtgaaccc ggtgatcccc
       61 gagatggtca accagatcgc gttcgcgacc gtcggcgcgg acgtcgccgt caccatggcc
      121 gccgacaacg gccagttgca gctcaacgcg ttcgaaccgc tcatcggaca tctgctgctc
      181 cagcacatcg gctggctgac gcacggctgt tcggcactgc gcaccctgtg cgtggcgggc
      241 atcaccgccg accgtgggcg actcgcgcgc ggggctgccg gcgcggtcgg cgcggtgacg
      301 gcgctcgccg cgcgcatcgg gcacgaggcc gcgacggagg tcgcccggga cgcctcgcgc
      361 accggcgccg acgtcgtgga cgtcgtcgta cggcgcgggc tgctggaccg cgagagtgcg
      421 ctgcgcctca tcgccgcggt cggctgacca cccgggacag cgccagcgcc gtcaccgtgt
      481 cccgtacacc gggcatctgg gccatctgct cccagatgcc ctgtacgcgt tccagggagt
      541 cggcctcgac gctgaccagc aggtcgaact gaccgctgag gacgtcgcag gagaccacct
      601 cggggatgcg cttgagcgcg gccaggacct cggccccgcg catccggtcc tcccggtaga
      661 ccagcacgtg cgcggccacc gtctcgcggt ccggaccgca cgaaggacgc acgatcgtgt
      721 aaccgccgat gtgcccctgc cgctccagcc gttcgacgcg ctggcgcacg gcgttgcgtg
      781 acagccgcac gcgctggccc agttcggcgt gggagatcct ggcgttgcgg gtgagttcgg
      841 tgatgatccg ctcgtcgatg gcgtccatgg cctgcgtgtc tcctgactgg cgaaggctcc
      901 ggtggccggg gggccaccgg agccgctgtg cgttcacgac gtcgtccgtc tccgtgacgt
      961 cgatcggtcg taccgtgacg tcgttcagtt ctcgtggtgc agggcgaaga cacgggcggg
     1021 gaagcccgaa ccgccgagcg gcttggccca ggtggcgacg atcagcgctc ccgcctccgg
     1081 tacgcggtcg aggttggcca tgagctcgat ctgccagcgg tcgcgccgca ggacgtagtc
     1141 ctcgaggccg aagtcgcccg ctgaggtggc cagtccgggg tcggtgtcgg tctgctcgtg
     1201 cccgatcgcc gtgacgcccg cctcctcgaa gagatggcgc aggacctccg cggaccagcc
     1261 ggggcagtgg ctcacacccg ccgcgtcccg gttcgccatg gcggccgggt ccggccagcg
     1321 ccggccccag ccggtgcgca gcgcgacgaa cgccccttcg gggacgcggc cgtggcggga
     1381 ctcccaggcc gcgacgtccg ccagggtcgg caccgcgtcg gggtccgtgg ccacgcgctc
     1441 ggtgatgtcg aggacgacga gcggcaggat catctcgtcg acgggtatct cgtccagggt
     1501 ccggccgccg gccacgaagt ggaccggagg gtcgacgtgg gtgccccact gtccgacgat
     1561 cgtgtacagg tgcacgttga agccgtcgcc gcgcgacatg tcgaacggca tctcgcgctt
     1621 ctcgtcggga aaggcgggga agtgcggctg accgggatgg aaggcgtgcg tcaggtcggt
     1681 gcggaccgtc ccggcggtca gttcgcggtg cagggcccac agcgggggct cggtggtggt
     1741 cgcgggtgcg gccgtgcggg ccgtgtcggg tgtcatgcgt gttcgtcctt catctcggcg
     1801 ccgtttccgg cgtggtccag cagatcgatc cagtcgacga gttcggcggg ccgggcgacg
     1861 gaggcaaccg cgtgggccga ctccgcgggg ccgccgtacc cccaccgcac gtggacggcg
     1921 gggatccctt cggcggccgc gctctcgacg tcgtacgcgc ggtcgccgac catgaggggc
     1981 cggcggacgt cggcgccgcc cgaccgcaga cgggccaggc actcccggat cacctcccgc
     2041 ttcgtcgtgc ggcccgcctc ctcgcgcacg ccgcacacgg tcggcagccg ggagccgaga
     2101 ccgaagcgac ggaccatcag ctcggcctgg tcctgcacct tcgaggtcgc gacacccatc
     2161 ggcagaccgc gtgcggccag ggcgtcgagc agttcgggca caccgtcgta cagcgcggcg
     2221 gccgtcgcgc cgtcacgggc gtacgcggcg cggtagaccg tgagggcggc ccgggcggcg
     2281 gcctcgtcga gtccggccac gcggcggaag gtgtcgtgca tcggcgggcc gacgaaggag
     2341 cgcagggtgg ccgcgtcggg gaccgccgcc ccgacggaac gcagggcctc ggcggcgctg
     2401 gcggtcacgc cgggagcgga gtccaccagg gtgccgtcca ggtcgagcag gacgcaggtc
     2461 ggcgctctca cgcgaccacc ccggcggtgc ggcggcggcc gtgccgcagc cagtggtaca
     2521 ggtagcagcc tgcgacgaac gggacgccga agtacagggc cgtcgcctgt gccgggtcga
     2581 gcgcgatacc gacgagcgag gcgaggcaca ggacgaaggc gagcactgga acgaccgggt
     2641 acaagggagt ccggtagggg agggcgcccg ggtccccgcc cgcacggacg aaggcccgcc
     2701 ggtggaagaa ctgcgcggcg gcgatggaca tccagacccc gaccgcggcg aatccggcga
     2761 tcgacaccag gacgaggtag accgtctcgg gcgccgcgac gctgctcacc agggaggcga
     2821 gtccgccgag catgctcagc gacagggccg tcagggggat gccgcggcgg ctgagccggc
     2881 gcagcgcctg cggcgcctgc ttctcctcgg cgagcgagaa gagcatgcgg gcgcaggagt
     2941 agaggccgct gttgccggcc gacagcagcg ccgtgatgat cacgaagttc atggcgtcgg
     3001 ccgcgtaggg gaagccgatg gaggagaaga cggtgacgaa cgggctctcg tccaggccca
     3061 cctggtcgta ggggatggtc gcggcgatca ccgtgatcgc gccgacgaag aagaccagca
     3121 ggcgtacgac ggtgacgcgc agcgccttgg gcacggcctc ggcggggttc tcggtctcgc
     3181 ccgcggcgac gccgatcagc tcggagccgg agaaggcgta gaacgcggcc agcacggtga
     3241 ccaggacgcc cgagaaaccg tgggggaaca ggccgtcgga ggtgtggaag ttctccagca
     3301 gcacggggtg ggagccaccc tcggcgagcg ggtggaaacc ggccagcgcg gcgccgccga
     3361 acacgatgag ggcgaccacg gcgatcacct tgaccagcga gaaccagtac tcggtctcac
     3421 cgaacacgcg cgccgagaag gcgttcaccc cgaagacgac ggcggcgaag accacgcacc
     3481 agacccagac gccgacgccg gggaaccagc gctgcatgag cagcccgcac gcggtgaact
     3541 cggaaccgag ggcgacggcc caggtcagcc agtagagcca ggcggtggcg aacccggtgg
     3601 ccgggccgat ggaccggctc gcgtagacgt ggaaggcgcc cgagacggga taggcgacgg
     3661 cgagttcacc gaggcaggcc atcaccagcc agacgacgaa cgcgccgacg acgtaggcga
     3721 ggacggcacc gagcggaccg gcctgggaga ccgtgaagcc ggaactgagg aagagcccgg
     3781 aaccgatgac gccacccatg gcgatcatga cgaggtggcg ggagcgcatg gtgcggcgca
     3841 ggccgtcgcc gggcggcccg ggaacggtgt ctgcgtcggc cggagcgctg tccgggactg
     3901 ctgagacgga catggggtct cctctgcgga gctgagcggg gagaggggga cgggcgtggg
     3961 gggtgatcgg cacggcatgg ctgagggtgg ggccactttc gaggggtgcc ggtgcgcgtc
     4021 ggggtggtcg cggaccgggg gagcgggcgc ccggtgcggg cgacgggctc acgggggcgg
     4081 ggcagcgggt caggcccggg agacgaggtc cagcggcgcg gagagttcga tcaccgggac
     4141 ctcccagggg tgggcgtcgg cgaggcggtc gagaagccgc gcgagggtgt cgtcgtccgt
     4201 ggcggcgtcg acgtacgtgg tcacggcgag cgtggccgag aggaaccgtc cgccgaccga
     4261 gccgagggag gggcgggcgc cgggccggac ggagaaaccc tcggcgccga gggagacctc
     4321 gaagacgtct ccgtagacgc cgaagtcccc gagctcgggt gaggtctcca cgatgcgcag
     4381 gagggcggcg aaggactcgt cggcccgcag cgcgtccagg tcgcccttcg cgcaggcggt
     4441 cagggtcgcg gtcgcgaccg gccagtacac cttgatcgtc cggaccgtgc ggcgccggac
     4501 gggtgcgggg gcgccctcgc ggtcctgtgc ggtcggttcc ggcgtgatcg tcgtcgtggc
     4561 catgcgcgtc tcattccttc ggcatccggc ggcgggtgat gcaaggatgc taggcgtgca
     4621 ttaaatgcac ggcaagatgc agatgctgca cacttcgagt ggctgtcgag gcggcggtac
     4681 agttgcgcac cggcagtgac caggacggca ccgcggcgga ccgcgccccg gcacggcgga
     4741 ggaacacgtg gactcaagcg tcacgaaggg cctcgacgcg ctgtcggcgc tcgctcgcgg
     4801 tcctgccggc ggccggccgc ccggctccgc cgcatccgtc tcggaactgg cccgcggcct
     4861 gggccgcgac cgcagccagg tctcccggat gctcaccgcc atggcggcgg aggggttcgt
     4921 cggccgcgac gagggctccg gcggtttcgc accgcactgg cggctctaca ccgcggcccg
     4981 cgacctcacg gcccaccggc tgcgcaccga cgggctcacc gccctggaag gcatggccgc
     5041 cgagaccggc gagagctgct acctgggcgt cctggccggc gacgccacgg tgaccatcgc
     5101 cgagcgggtg cccgcgggca gccggcagct cggctcgtgg atcggccgcc cctacccggc
     5161 gtactgcagc gactgcggcc aggccctgct gagcgacgcc gacgacgacg aggtggcggc
     5221 ggtcttcgcc cggacggagt tcgtccgcca cgggcccaac acccccaccg gcccggagga
     5281 cttcctgcgc cgccttgcgg ggacccgtcg gcgcggatac tccatcgtcg acgaggaggc
     5341 cgagcccggc ctgtactccg tcgccgtgcc ggtccgcgac ttcaccggcg aggtcgtggc
     5401 cgccgtccag gtcgtcggcc cgcgacggcg cctggagccg agaacccagg agtgcgcggc
     5461 ggccgccctc cgctgggccg gccacctgga gacgtccctc cgcggaacca cctgaccggc
     5521 cgcacccggc cgtccggctc gcgagggcgg gtccggatcg tcggccgggc cggtcggtca
     5581 ggtcacggcg gccgaggtca cggcggtgct gcgcgcccgc ccgggaggcc ttccgggcgc
     5641 tgcacccagg gcgagcgtcg aaggcgtggg cggcggctga cgtgccgtag tactcctggg
     5701 cggacgggct acacggccgt gcgggcgagc ggcgcggaga tcgtccatcc cttgcaggac
     5761 gaggagtggg gcgtgcggcg gttcttcgtc cgcgaccccg gcggacgggt cgtcaacgtg
     5821 ctgggccacc gctgacggcc ctcccgcgcc cccggcgacg ctgcggcgcc cgcgtacccg
     5881 tcacgacggc cgaccgggaa gcagtgcgaa aaccccttgc tcaatggtca agaaacgttg
     5941 accattgctc gcatgcctac cgacgacctc cccgagacgt tccgcgtcac caccgacgac
     6001 cagctgcgcg ccgtttccaa tctcacgcgt caccggatca tggccgtgct gcgcttcgag
     6061 ccggcgacca tcacgcagat cgccgaacgg gtgggcctcg cgaagggcag ttccagctac
     6121 cacgtacggc tgctggagcg ggccggcctg gtcaaggtgg tgcggacgcg gaaggtgcgc
     6181 ggtgtcaccg agcggtacta cgcgatggcc gcgcgggcga tcgagctccc ggatccgggc
     6241 gagggagggc ccgatgtgct gatgcggcat gcggtggcgg acctggaagc ttcgccggtg
     6301 gacggcgagc ggcacgtgag gatggcgcat ctgcggctca ccgaggagca gttcgcgcag
     6361 ctcggggcgc ggctggaggc actggcggac gagtaccggg agctgtccga tccgtcgctg
     6421 cccgacgcgt ccctcgtctt cgccctgttc cacccggccc ggcgcgcacg gatcgaggga
     6481 gacgccaagt gacgcagaca gtaggtaagt tgccgaccgg gttcgggcgc ctgtggaccg
     6541 cgcagacggt gtcctcgctc ggtgacgggg tgtcacatgc cgcgctgccg ctgatcgcct
     6601 tgaccctgac gcgggacccg atggcactcg ccgtcgtcac ggccgccggg acgctgccgt
     6661 ggctcctctt cggggtgctc ggcggcgcgc tcgtggaccg ctgggaccgc cggcacacga
     6721 tgtggatcgc ggacacggca cgtgcggtgc tgctcgtgac acccgcggcg gcggccgcgc
     6781 tcgacctgct gagcattcca ctgctggcgg ccgtcgcctt cctgctcggc ctcggcggac
     6841 tcttcttcga caccgccgcc acggcctatc tgccggacct gctcggccgc gaccccgaac
     6901 tgctggagcg cgccaactcc cgtctgcgcg gtgcccagac cgccatgtcc ggcttcgcgg
     6961 gaccgcccgc gggcagtgcg ctgctcgcgc taggacgggc ggtcccgctg ctcaccgacg
     7021 cggtgtcgtt cctggtctgc gcactgctcg tccgtacgct gcccgctctg cccaggcccg
     7081 cgccgaagac ccgtgagccc ctgctccggc aggcgcgcgc cggggcctcg tacgtcttcc
     7141 gggaccgggt gctgctcggg ctggcgctcc gcccggcggt gggcaacgtc gccttcctcg
     7201 ccgtcgagac ggtcctcgcc ctcttcgcgc acgagcgcct cggcatcgac acctacggct
     7261 tcggcctgct cctcacggcg gaggccaccg gcggtctgat cggtgcgggc atcgcctcct
     7321 ccctcggccg acggctcggc accggcaccg cactgacctg cacggccgcc gtagaggggc
     7381 ttgccgtcct gggcctggcc gcggcctcga acccgtacgt ggcgggagcc gcgctcgccg
     7441 tctgcggagc gggcatgggc gccaccatgg tgctcggacc ctcgctccgg caggcgatcg
     7501 tcccggcgca cctcatgggc cgggtcgcct ccacctcccg catgctcgcc atgtgcgcgg
     7561 cccccgtggg agccttcctg ggcggctggc tggccgctgc ccacgacatc cgcaccccgc
     7621 tctttgccgc cgcgggcctc ctcctgacga tgacggccgt cacggcatcc atgaccggca
     7681 accgcagggt cgaggcggcg ctgcgagccg cagccccggc ggacgtccgg gaggccgagg
     7741 agagcgcggt cggcgggtcg actccccttc ggtgaagcgc cacgggcgca ctgtcggtgt
     7801 gcggggcacg ggtgtgtgcc gggggccggc cgcgtcgagg ggacaagcat gccgccgacg
     7861 ccggaacggg gagcatccgc gtcggggcac gaggaggaac cccggctgga cagccgcgag
     7921 ggcgccgagc cggcgtcggc ggtgtgcgcc tcggtgtcct gagtcttcaa cggcgcgctg
     7981 ccgtactgca ctagggtgct cgctgcgtcg agcccagggg gagatcatga caaccgcaga
     8041 cgacgtgccg aagccgatcg gcacgctgtt ccggatcccg ggattccggc ggtacgtgtc
     8101 ggccgatctg atctcggcga ccgggtccgc gatggccccg ctcgccctgg cctacgccgt
     8161 catcgggcag gggggtggcg cgggctctct cggcgtggtg ctggccacga acaccgtgcc
     8221 cacgatcgtc ttcctgctcg tgggcggctt gttcgcggac cggttgtccc gcagccggct
     8281 cctcttcgtg ggcaacctgc tggccgcctg cgcccagggt gcgctggccg tcaccgtggc
     8341 caccggacat gcgacgaccg cgtcgatcgc ggcgtgcggt ttcgtctcgg ggacggcggc
     8401 gtcgttcatc gtgccggccg cgcagggcgc cgtcgcacag atcgttcccg aggagcacct
     8461 tcagcaggcc aacgccttgc tcaggctgcc gggcaacgcg gtcaaggtac tgggcccggt
     8521 ggtcggcggt gtcctcgtcg ccgcgagcgg cgccgcctgg gcgctggcct gggacgcctg
     8581 cacgttcgcc gtcgcggccg tcctgctgct cggcctgcgg ctggacgcgc cactcgtgac
     8641 gagcgagggc gtcctgaggg atctgcgagc gggctgggcg ggcttctggt cgcgtacctg
     8701 gctgtggacc tacacggcag ccggcatgat cctcgtcgcc gcgtggctcg cgggtttcca
     8761 gcttctcggc ccgctcgtgg ccgaggaaca gtacgccgga gcccgcgact ggggcctggt
     8821 ccaggcggcc ttcacggccg gcctgctggc gggcaccgtc gtctgtctgc ggtggaagcc
     8881 gtaccggctg ctcgcggtcg cggtggtcgc ggccggtgct ctcgcgctcc cgttggcggc
     8941 cctggcctgt gcggtgccgc tggccctcgt cctggtggcc gtcgtgctcg ccggggtcgg
     9001 gctcgacatc gcgatcgtcg cctggaccac cgcgttccag cggcatgtgc ccccggcgga
     9061 acagggccgc atgagtgcct tcaacggcgt cggggagcgc ctcgccatcc ccgtcggtta
     9121 cctcatcacc gccctcgcgg cgcactcctg gagcacccag gccgtgctgc tgacctgcgc
     9181 gggcatgatc gccgccgcga cggtcctgaa cctctgcgtc ccggacgtgt accggatcaa
     9241 ccgccggacc gaccgtcggc caccggacga tcagccgtcg gccgcacagg ggcaggggca
     9301 agggcagggg cagggacggc cagggcgacg gcgggggcgt ggcacggtgg agcagacgta
     9361 ggcccgaccg gtcacgaccc ccccccccat ggtggtgccg gacaccccgc gcataggtcg
     9421 cgaggcgtag gtcccgggcc tcaggcgcgc tcggagcccg ctggctaggg tcggtgtcca
     9481 tggacaccac gggaatcgtt cggcgcccga cggcggagcg cgtgcgcgac accacggagc
     9541 ggctggccgc cgagcgcgac gtgtgggtgt cgacggccca cccggatcac gggccgcacc
     9601 aggtgccgct gtggttcctg tgggacggcc gagcggtgtg gctgtgcacc ggcgccacct
     9661 ccgtgaccgt gcggaacgtg cgcgccgagc cgcgtgtgcg cctggcgctg ccggacacct
     9721 tcgacgtggt gctcctccag ggcgaggcgg aatgctccac ggagacggag gtccccgcac
     9781 cggcggcgga ggcgttcgcc gccaagttcg gttgggaccc gcgcggtgag gagggctcct
     9841 tcgtgtacgt acgggtcgtc cccaggaccg tgcgcgcctg gcgcggcgag ccggagctgc
     9901 gcgggagggc cgtgatgcgc gacggcatgt ggctggagca gccgcccgtg ccccggccct
     9961 gaacggccgt cattcgacgc gggccctgaa cgaccgtcat tcaaccggcg tgaggggacg
    10021 gagcgtcgag gggccgggtg cgcagcacct gggcgaggtg gccggggccc gacgccggga
    10081 cgatccgggg cgcggcgcgg tagcggagcg tctcggtctg ccaggcgtgg taaccgctca
    10141 tccaggcggc catgatctcg acgtacgtgt ccacggcggc ccgttcgtgc ggccgcagac
    10201 cgagccgacc gcacaacgcc gttacccggc ccgccagttc cgcgaagcgc cggacgtttc
    10261 ggttcacccg gcggaccgcg gccgcgaccg cctcggcgcg ggtgaggcgg cgggtgtgtt
    10321 cgaggacgag gacgaggttg tcgacgtcac cacgggcctc ctccttctcc agggagtaca
    10381 cgtcgttgca catcagcgtg acgtcgatgg cagtccgccg catgatgcgc agctcgggcg
    10441 cgtggaaggc cgccgcgggg acggtgatgc cggcggcccg ctcgcctagg gagagcggca
    10501 ggtcggtgcc ggcgatgcta cgacggacga ggaggtaggt ctccatgtcc gcgggcgtgc
    10561 cgcgcagccg gcctatcgct tcatgggcgt gcgcggcgaa gtagtactcc cactcgtgcg
    10621 cggtgcgagc cgtccacgcc gggtcggcgc cctggatgcc acgggcccgg acgtcggcga
    10681 aggccgccgt gcacgcgtct gcgtcggcgg gcggggcggc accgtgcgcg atgtcgatca
    10741 accggcgaca cacctggacg accagggcgg ggtccctgcc gagcgggccg tcgaactggt
    10801 cgtcgaagac gaagaagaag cccatcgcgt ccgcgcacag gtccagggca cgtccccggg
    10861 cgtggggaaa accgagggcg gccagacggg tcatgtccca cgaggcgtac caggccgcgg
    10921 aacggtcgtc cgtgaccagc cccagcccgc ggacccagtt cagattgcgc cgacgggtct
    10981 cgtcgagccc gggcccgggc ctggtcgccg gggggagatc gaagtcgacg tcctgcggca
    11041 cgaggtcctc cggtctatcc ctgtgtgtcg ggttctgccc ggcccggggc ggggctcgac
    11101 aggtccagcg cgagcggctc cgcaccgccc gcgccgagct gttcgaggga gaaggccatg
    11161 gaagcactga ggctcgacgg agtgcggaac ccctcggttt cgcggacttc gcagagccgg
    11221 tccctgatcg actcgggcgt ggggtcctcc ttccagagca ctccttcggt ggcgcccagg
    11281 aagatccggc cgacgcgtcg gccggcggcg tgcagcagct ccccggtgca cggcacggac
    11341 tcatgggcca gcagggccac cacggacgcg acgagccggg ccgggaacag gtcggtgagc
    11401 agggcggtca tcggctcgtc gtcctggagc gcttcgaggg acatccgggt ggcggcgatc
    11461 ggtacgaccg cgttgacctt gatgccgtgc gcggcccctt cggcggccag tgacgtcgtc
    11521 agccccagca cgcctccctt gccggcggcg tacacgctga gcccgttgtc cccgaagagg
    11581 gcgtcggagc acgtgttgac gatcctgccg tagcgggacg cgagcatgtg cggccagacg
    11641 gcccgcgcca tgttcaacgt cccgcccaca tgggtgtcga gcacgcgccg gcactcgtcc
    11701 tcggagagct cggtgagagg gcgcaggatc gagattccgg cgttgttgac cagcacgtcc
    11761 agccgtcccc agcgctccac ggcggcccgc gtcagggccc gggcgccggg cgtggtggag
    11821 acgtcatgga cgtcggccac cgcagtgccg cccagctgcc ggatctcctc gaccaccgcg
    11881 tgcgcgggcg acggcgactc tccgcacccg tcgatccccg tccccacgtc gttgacgacc
    11941 acccgcgcgc cgcgcgccgc gaggaacagg gcgtactccc ggcccagtcc acggcccgcg
    12001 cccgtcacca cggccacgcg atcctcgaaa cgcatctcgt ccactccgcc accgccctcc
    12061 cggaacgcca gtgatccccc cacaccctgc cccggcggcg ccgccgcggg cagggagcgc
    12121 gcaaatcgcc ccgacgcatc cgcacacgcc acgagtgcct ccgaccgctc ccacacgcgc
    12181 cgttgcgccg agcgcgtccc gtccggaccg gcaggcccac cggcccggcg cccccgcccc
    12241 cacctgcgac cggactcccg tccgtcggca ccgggccgtc atgagtcggg aggaccgtga
    12301 cattctgtgg tggtgcttct cagcgatcac gcgaccggcg tcgaactccg cctggtgggc
    12361 taccagttcc cggagacccg gggagacgcg tacgacgaca actggctggt cgtcgcggcg
    12421 acggtgacca cccccgaagg cagctggtcc ttcaccgatc cttgcctgct gaccgacgag
    12481 gcgcgtgagg tgtccgtctg gctccgcgcg gcggcttcgg gcgcggtggg cgtgaccgcg
    12541 ccggaccggg acggccggct atggccggac acctggttcg tcgaaccggt cctgggcttc
    12601 agcctcgccg cacgaagcga cgaagcggcg gtgatccgca tccacctgtc gtcggaggcg
    12661 atcccgccgt ggcggcgcga cgacagcgcg gacatctacc agtacgccgt ggacgtcatg
    12721 gtggagaaag aggcattgct gcacgccgca gaccactggg accgagcgct ggcctccttc
    12781 ccgccccgct gaccgagcga cctccgtgcc gccaccggac cgacgtgccc ggcgtgctcg
    12841 gactcaaccc cgccgcaccc gcggctgccg gcgctcgacg cggtcgaggt cgccggcgag
    12901 aaggtcctgg tgactgatgg tgaagtcgcc gttgagcagc ttctgttcgt cgccgtagta
    12961 gtcgcccatc acggtggcgg gaaggaaggc acgcaggctg tgccgcatgg ttcccgggtg
    13021 gtcgacgggt tcgccccagc cctcaggagc ctggtcggtg gagaacagga cccagtggtc
    13081 cacggacacg gcggcgtcga ggtccggagc cgctccggtg tggctgtcca gagccggcag
    13141 ggtcaaccgg tccgggtcca gcggcgggta ccacaacagc aagggcttgg cgtcctgcgc
    13201 gtcggcattg tcgaagcagc acagcgcgat ggtgtgatcg gggaagtggt cggcgtagaa
    13261 acgcaggagg tccgggtcga gatccggccg gcgatgcggc ggtacctgcc gcagggcggc
    13321 ggtgacagcg gtggggtcgg cggcgaggag caccgtgtag acgtcgtggt cgaagacctg
    13381 gacgctctgg ggttcggcgc tcatccacgc gatgccgtcg gtcgcgacgg cgacgggtgc
    13441 gaccgcatcg accatgcggc gcaggacgtc gccggtgcgc cccgcggaga tgaagttccc
    13501 cggggtcagc cgctgccggg cgggcaggtg cagcagcatg gcgttcggtc cgtccgccag
    13561 attgacggcg gtgttctgat aaccgagcac gtggatcaga ccatgcaccg ggtggtgctg
    13621 cctcccgcag tacacgatcg tgccggagaa cgcggcctca cccgtcgaaa tgcacatgcc
    13681 ggcaaggtac cgcccagccg cccagagttc cgtgcaggtt cagtcatcgg ggtgagtcgt
    13741 gtggatcgtg agtcctgtga tgcgtcctga ctggatcacg ggaccgtgct gcactccgcc
    13801 ctcgatgctg ttgtgcacgg tcgcgggttg tgccggctcg tcgcgcaggc gctgcaacga
    13861 cgtgaccagt tcgcgcagtt cggcacagga agccgcgtgg acctccagga gttgtcggac
    13921 gcgtgctccc cactgctcga cggtgtcgtg agcgtcgcag gggtggccgg cggtccgtgc
    13981 ggcgaggagc cggccccgca cgccttcgag gtcggtgatc gctgaggtgt cagcgtcacc
    14041 ccgtgagagg aaccgccgaa gaagctcacg tgcgtgcgac caggagtcgg tcaccaagag
    14101 cgagaccagt gtgctcgctc cggtcgccga gagagcggcc aactcgctgt ccatggttct
    14161 ccttcggggc agagctcgga cggaggacgt acaacggcgc gggacgtacg acgaagcgcg
    14221 tcacgccggc tcctccggtt cgtctcgccg gtcgtcggcg gaggtggcga agtccgccgg
    14281 tgggtcgtat cggcgcagga gctcatcggc cgtctcgtgt ttgtcctgcg ttctgatgac
    14341 gtcggcgatc tgtttggtga gcatcgccca cttgtcgtca ccgcgggtga gacccatgcc
    14401 ggtgaggaac gcctcgaagt ggtcgggagc cgtctgttcc ggtccgacgg gagtggaggg
    14461 ctcgtcggac gcagcgatga ggccgcggag ccggtcgggg atgtccgtgt cgttggccgc
    14521 ggacgtgagc tgcgcgagga gcccgaggtc ggcgacggtc ctttcgatgt ggttgtcgtt
    14581 cttcgccagc caccagacca ctgcgctgcc tgtgtccttg aggacgtcgg cgcccaggta
    14641 ctcgcgcatg ctctgctcgt atttccgctg gtgttcccag accgcctcgt ccttgcggac
    14701 ctcggcgagc ctgttcagcc gctcctggtc gggctcgtgc agggtgagcg tgatgttctc
    14761 cgccatgacc cggagatgtc cggcgcggtc cgggcgcatc ctgccgagcg caccgctcaa
    14821 ctcatgctgc acgaaggaaa cctgcccggg ttcgcgctgt tccgtgagtg tgcgggcgcg
    14881 gtccaggatc gcttcgacag cgagaccggc cgggttgagg acggggtcgt ctccgtgagt
    14941 ctccaaggga tgccagcgca cggtcgcgga gaacaggaat tcgtagtcgt cccagttgct
    15001 gggcagggag acccggctca ctcggtgttc cctgcgctcg atcggtgcgg cggggatgaa
    15061 gttcgtgaag tccgcgggca gagcgccgcg gcggactgcc gcgatcttga aggctgcggc
    15121 ggggacaccc gcgaccgcga cagcgagcgc ggcccaggcc cacaggggcc actcctgtac
    15181 gaggccgaga atggtcagca gcagggcgca caggacggtc aggaatacgg tcgtcgtctt
    15241 gcggccggtc gtcatcgtgt ggtccccctg gacggtggtg cggcgggcgg gtgcaggccc
    15301 tgagccgtgg agatcttctg gagcagaagc ctggttgtcg cggcaccgga agcccgatcg
    15361 ccgggagccg cgggctctac ggttcgggct gccgcgtaca gggccgcgag ggtgctgccg
    15421 ttccggccgg cggaatcgac cagcaggaag agcagccggt cgcgatggct gtccacgaca
    15481 caggccgcgt gcagccatcg ttcggcgtac ggtcgccagt gcgcctgcgg gagccgggtg
    15541 aatgcttccg accagcctgt caccgtgcag tcctggacgc ccttctcgtc gatgagcgga
    15601 tgcgctgcgc ccgccgggtc cgtgagcgcc atggggtcgc agatccgcag aaagaggcgg
    15661 gcgtcgatgg tgggtgaggc cgagagacgc gtgacgcggt cgagcaggag gcggcggagc
    15721 cgggaactgg tcgccgagag gcggcacaag gcgtccagag cgggcgtcgc gccgcgttcc
    15781 cggcgtgcga ggtggtgcag acgcgtcacc gcctggtcgg ggtgagtcgg tgcgatcacg
    15841 tcggtgcagg cccgcagaag gacatgtgcg agattcccgc tcagtggctt gtccttgcac
    15901 caggtgtaga cgagcatccg cagactccgg ccatagcgag ggtcgcggag accgcaggcc
    15961 agtgcgtcca ccgcggccgc cagtcggaca cggctcgcgg gtgcactgct ccacttctcc
    16021 gccagaagcg ccagatcgag tcctcgaccg gtgcgcacgt actgttcggc gagccggccg
    16081 accagtctcg tgcgcagctc cgcgctgaga tgcggatcgt ccagctctgt gctctcggcg
    16141 gtccagatgc cgaaccggtg ccgcagatcg ggcatgtggt cccagaagtg ggcccggacc
    16201 gcgacgtcat agtccagttt gccgaagcgc acatggccgt ccggccgggc tgccgcaccg
    16261 atctccgtca agcgctgggc caggtcgggg ccttcgagcg caggcatctc gtcctgaggc
    16321 gtgtcgtgga cggtgagcat gagtgcggcg ccctggtgga cgaggtcggc gtgcgcgccg
    16381 tggaacatgg cggtggcgaa cagcagcgcg cgctgaggtg cggcgcacag tgtggcgaca
    16441 caatccgcga cctccttgcg ccacgcgctg tgtgcacgcg agttcttgca ccaggtggcg
    16501 aagccgtctc gatccggagc tgccgcacgg gctcggcgga cgcggtcggc gaagtgagcg
    16561 atctcctcca tcgggggctg ctctgccagg aactcgtcca gcgcgggggc ggggagccgg
    16621 aactcctcgt acggtacgcg gtggagccgt agatgccgcc ggaagacttc catggcaggg
    16681 ggacgggcga tatcggcccg gtagggttgc agatgagact ccaggccgcc gtcgtgcggc
    16741 atgacgacca cgagatgtgc cccttgttcc agtacggcct tgcgcagtgc tgacaggtcc
    16801 cggcgagtct gcgcccattg ggtgatgtcc gcctcggcaa ggttcagcag cagccggtca
    16861 cccgcgccga cgagaccggg gccggtgagg gcaccctcct cctcaccggg cagaagctcg
    16921 cggaagatac ccgcggttcg ctgaacctcg tacagcagga cgcgcgcagc cgcggtcctg
    16981 ccgctgcccg gagcgccgct caggatcacg gtgctgctgc catggagtac ccggcgtgcc
    17041 gtgctcattc ctgtggggtc gacgaactgc tgccgcagga gccgcagctg gtcatcggcg
    17101 atccggcgcg gacttcgggt ggtggcctcc tgttcggcaa ggcccacatt gacggtgtag
    17161 ctgtagaagt cgccggaacc ggagtggact tgaccgccgg gctgctcgat gtgcgtggtg
    17221 aaggtctcgc tcaccgttcg tcgtccccgg agctgcccgt gtcaccgaag cgatgccgga
    17281 tgtcgccgcg gtgatcgccc tcgatgttgg tcatgccgtc gcccgagtag tgccggccac
    17341 cggagacatg gtgcgagttc tgatagatgt tcccgcggcc cgaatgaacg ggaccggccg
    17401 acccgttgat cactgtgctg ttcaggtctc cggcgaagtc ccggctctgt acggccgttc
    17461 cggagacggt gccggtcgag ttggacacgg aaccgggatc gggtggcgct gcctcggcgt
    17521 gctcgaggtc gtacagctcg gggaccatct cggccaccag gtcgcccagg cgcttgaggt
    17581 cggcttcagc gttctgcgtg tccagccgta cggactgcag ttcggccagc ctggccagtt
    17641 cgtccggcag ccgttccttg ctgaggcgtt ccgtccgcct gccggcgagg acgggcacga
    17701 cgggaacccc gcagtcgaac gcctccatga tctccttgcg gacccagtct tccgcatcat
    17761 gcagccggga ctggaagttg agccagtcgg gcccgatcac caccagaacc agcgcgctac
    17821 gacgcacgcc catgagaagg gcgtcggggt atgcggaccc cggcgggatc gagtgcgaag
    17881 cgcggaacgc ccggtccttg ccgaatcggt tggcgagctc gttgtcgatg agggcggcga
    17941 tgtcattgcc gtcccccgtg cggtagttga tgaacacgtc gggcatgtga gagtcctttc
    18001 aggaaaaagg aagtcgggac agcaccgcca gacggggccc cagccgtcgc accgcggtgt
    18061 gggtggagtg gcgggccagg acacgggaga ggcgacgcag gtcgatcgtc acggtggcgg
    18121 accgtacggc cgtgaccccg tcgagcagtg gcgccaccag gtcgcaggca tggtcgatct
    18181 cgccgtgcga cgcgtatgcc agggcccgcc gtacgccata acgcacctgc gtgcgtacgg
    18241 cgtcaggtga gaccagagcg agttgccggt ccagctcttc ggcagcccgg cccgcctcac
    18301 cgaggtcgaa caggcaccat cccgtgacca tgccgaccga atcgggcagg tgcatgctgc
    18361 cgatcaccgg agtgtcatgg tcgatctcct gacgggccag cagggttcgg gcacggtcca
    18421 gagcacgcat gcaagcgtcg ctgtcgccgg caagagcgtg tccttgtgct tcgcgctgcg
    18481 ccgccagccc gcggatccgc gtgggaagcg tgtcgctctg tgcccggcgt gcgagcgaga
    18541 cggtctgctc ggcgtcgtcc tggtagagcg tgaccagggc tcgccggacc agagcgtatc
    18601 cggccagtgc ccggtcgccg ccggccgcgg ccaggtccac cgcacgctgc gtccaccaca
    18661 gcgctgcctg ctcgttgccc gtctcctgga cgagccagcc cacgtactcg gcataccggg
    18721 aacccagcgc cagcaattcc cgtcgggtgc gcgcatccac gtgtgcggac aactcccgca
    18781 gcgtgtgggt ctgcgctatc aggccaggca gcaagatccc gggctcagcg ctctggccga
    18841 gccgccggta gtgagtgaac agggaacgcg acgcgtccag catccccgcc cccacgccgc
    18901 cggtcggtga cacggggatt tggccacctg tgcgccaggt catcaaggaa gccgccccgg
    18961 cacccacgac ctgccgtcgc cccacgggct ggaacccgcc cgagccgtcc ggtgaaagct
    19021 gcatcaccca ctcctcctcg tcgaccccgt gcggagccgg ttccttcggg acgtcgccga
    19081 cggtcaaggc gaccaaagag atcagtgctc cgccggcgtg gagggccgcg tcgcacagcc
    19141 gagccagatc acggctgggt gctttgatgc ctcgctcgac cttgctcagc tgcgctttgc
    19201 tgtagtgcac ggcggaagcc aatgcggtga gactcaatcc ggcgtccaga cgccgcttcc
    19261 tcagctcttc accgaactcg ctggatggct gtggcacgga aacctccagg accgtccgtc
    19321 caggtgcaga ggcccgtcgc acgaaagagt gcggcacccc aggctggccg gacaaggcgg
    19381 atggcactgt ttcccgtttc ctctcccctg acgggaggcg gtacgcacag cgggagggac
    19441 cggccggacc acgtcactgt tcggcccctc gaagtcgtgt ccgaccgcgt tccgggccgt
    19501 tccgggcagc cgttcgcgct acgcccgcaa atggcctcgt acccttcggg caaccggaaa
    19561 cctggagggc ccgacaacaa gttggaaagg aggaacccgg gcaaggtctg caagggcagg
    19621 ccggacgctg atcctccccg aatcccgaac cgtgtcccgg tgttcgccgc cgtcggtcac
    19681 agggcggtgg cggcgcggac caggcctgct actgccgtcg agcggctgtg cggtggccag
    19741 gcgatgaccg tggtgacgtg ggcggcgtcg aggaccggta cggcggtgag gtcctcgcgc
    19801 aggccggtgc ggcccgactc cggcacgacc gcgcaggcgc ggccgagggc gatgagctgg
    19861 gtgagttgcg tgtggtcgcg cacctgcggt ccggggccgt ccgggaaggt gccgtcaggg
    19921 ccgggccagc ggggcagggg gaggtcggga aggccggtga cctcggcgag ccgcacctgg
    19981 gggcgggcgc cgagcgggtg gcccgccggg aggatcacga cctgaccctc ggagtgcagt
    20041 tcctcggtgt cgaagccggc cgtgtcgtcg aacggccggt gcagcagggc cacgtcggcc
    20101 cggccgtcgt gcagcaaccg tgtctgctcg cccggcccgc acagcgccac gtccacggtg
    20161 acggcgccgg gctcggcggc gtaggcgtcg aggagtttcg cgagcagttc gccggaggcg
    20221 cccgccttcg cggccaggac cacggcgggg cggccggtcg ccgcgagagc ggcccgtcgc
    20281 gtgcgccgtt cggcggcctc cacggcgtcc agcgccgccc gggcctcccg cagcaggacc
    20341 gcccccgcgt cggtcaggct gacacccctg ctgccgcgtt ccagcaggag cgtgcccagg
    20401 cgccgttcga gcccgccgat cgcccgcgac agcgggggct gggcgatccc gagccgccgc
    20461 gcggcccggc cgaagtgcaa ctcttcggct accgcgacga agtaccgcag ctcacgtgtc
    20521 tccaccccgc cagcctaacc gggacgacca ggagcgatac ccgggcggta tcgccgtcca
    20581 cccagtcggt cttggacgcc ctgcccgacg ggggagaagt atcgaggtca tgagtgagac
    20641 gaacaccgtg aacaacaagg tcgcgctggt gaccggggcc aacaagggca tcggctacga
    20701 gatcgccgcc gggctcggcg ccctcggctg gtccgtcgga gtcggcgcgc gcgacgagga
    20761 gcggcgcgag gccgccgtgg acaagctgcg cgcggccgga gccgacgcgt tcggcgtgcc
    20821 gctggacgtg accgacgacg ccagtgtgac agcggcggcc cggctgctgg aggagcgggc
    20881 cgggcggctc gacgcgctcg tcaacaacgc ggggatcacc ggcggcggac cgcaggagcc
    20941 caccacggtc gacgtggacc gggtacgggc ggcggtggag accaacgtga tcggcgtcat
    21001 ccgcgtcacc aacgccctgc tccctctgct gcgccgctcg c
//
