LOCUS       NZ_BMSI01000002        25622 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000002
VERSION     NZ_BMSI01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 655051)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 138616
            Orig. end                         :: 164238
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25622
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25622
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25622
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15622]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15622
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            1578..1895
                     /locus_tag="IE189_RS06625"
                     /old_locus_tag="GCM10010496_13420"
     CDS             1578..1895
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127189.1"
                     /locus_tag="IE189_RS06625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13420"
                     /product="hypothetical protein"
                     /protein_id="WP_189918795.1"
                     /transl_table=11
                     /translation="MTTYVITVPGTFTAEVGQETRARLGRALRPVDPHHTRMGSEQDLD
                     PLTVNEDDTFTIRLAVDADSAPLAEEDARRLADSALRAVGLDDTEAPLGPAVVTGIDSD
                     L"
     gene            complement(1950..2900)
                     /locus_tag="IE189_RS06630"
                     /old_locus_tag="GCM10010496_13430"
     CDS             complement(1950..2900)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980750.1"
                     /locus_tag="IE189_RS06630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13430"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_229901104.1"
                     /transl_table=11
                     /translation="MQRDSTQRDSARRGKSTGVPVGRGRKSVTLLAALGSCALVAASAV
                     PAAAHGGSGGGGGTRYVALGDSYTSGPLIPRQVDANCARSDHNYPSIVAGRLKASGFKD
                     VSCGGATTEQMWKAQGTNGPQLDAVDRKSDLVTVQIGGNDIGFGSIIGTCAQLAPQDPT
                     GNPCQRHYGASGVDHLTLAIARTAPKVSKVLRAVHERAPHARILVVGYPDLLPDDGSGC
                     APTVPFATRDFPYLRDTGKHLNLMLRLVARWNHAEYVDTYGPTIGHDMCKSPADRWIEP
                     LQPTSPAAPAHPNAKGEAAMAGAVWQRLAHGRGGR"
     misc_feature    2996..3009
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.25"
                     /tool="antismash"
     misc_feature    complement(3009..3027)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.06"
                     /tool="antismash"
     misc_feature    3065..3080
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.04"
                     /tool="antismash"
     gene            complement(3072..3710)
                     /locus_tag="IE189_RS06635"
                     /old_locus_tag="GCM10010496_13440"
     CDS             complement(3072..3710)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127191.1"
                     /locus_tag="IE189_RS06635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13440"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_229901105.1"
                     /transl_table=11
                     /translation="MTQDAVQDAQKPAEAGPPPRRRRGRGRRPAAEVRSDVLDAAGGLL
                     LDAGMGSFTIEAVAERAGVSKTTLYKWWPSKGALALDGYFHAVESALAFPDTGDLRADL
                     TAQLRAFVRILTLTPAGRVIAELIGQAQTDPELSAALLERYSGPRRDLAVLRMRGAQAE
                     GRLRPDVDPEVVVDQLWGACYHRLLLPNLPVDEDFADSLVANLWRGIGT"
     misc_feature    complement(3766..3783)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.94"
                     /tool="antismash"
     gene            3819..4553
                     /locus_tag="IE189_RS06640"
                     /old_locus_tag="GCM10010496_13450"
     CDS             3819..4553
                     /NRPS_PKS="Domain: PKS_KR (6-170). E-value: 1.6e-19. Score:
                     62.4. Matches aSDomain:
                     nrpspksdomains_IE189_RS06640_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669176.1"
                     /locus_tag="IE189_RS06640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13450"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_189918798.1"
                     /sec_met_domain="adh_short (E-value: 3.2e-36, bitscore:
                     120.2, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.1e-06,
                     bitscore: 22.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEITRVALVTGASGGIGRAVARRLAAAGTAVGVHYAGNKAAAEE
                     TVAAVEAAGGRAIAVNGDVADEGAMSDAFSAVEEAFGGVDVVIHTAGVMTLGPVAAFDL
                     DAFDRLMRTNVRGAFVVAQQAARRVRDGGAVVTFSTSVTRLAFPDYAPYAASKGAVEAM
                     TLVLARELRGRDITVNAVAPGPTATPLFLDGKDRQTVDRLAAQPPLERLGTPEDIAETV
                     AFLAGPGRWVNGQVLYVNGGIA"
     aSDomain        3837..4328
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS06640_PKS_KR.1"
                     /evalue="1.60E-19"
                     /label="IE189_RS06640_PKS_KR.1"
                     /locus_tag="IE189_RS06640"
                     /protein_end="170"
                     /protein_start="6"
                     /score="62.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGASGGIGRAVARRLAAAGTAVGVHYAGNKAAAEETVAAVE
                     AAGGRAIAVNGDVADEGAMSDAFSAVEEAFGGVDVVIHTAGVMTLGPVAAFDLDAFDRL
                     MRTNVRGAFVVAQQAARRVRDGGAVVTFSTSVTRLAFPDYAPYAASKGAVEAMTLVLAR
                     E"
     CDS_motif       3843..3905
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS06640_0001"
                     /evalue="2.10E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE189_RS06640"
                     /protein_end="29"
                     /protein_start="8"
                     /score="20.4"
                     /tool="antismash"
                     /translation="LVTGASGGIGRAVARRLAAAG"
     misc_feature    4736..4751
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            4777..6468
                     /gene="ctaD"
                     /locus_tag="IE189_RS06645"
                     /old_locus_tag="GCM10010496_13460"
     CDS             4777..6468
                     /EC_number="7.1.1.9"
                     /GO_function="GO:0004129 - cytochrome-c oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0015990 - electron transport coupled proton
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ctaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126378.1"
                     /locus_tag="IE189_RS06645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13460"
                     /product="cytochrome c oxidase subunit I"
                     /protein_id="WP_189918799.1"
                     /transl_table=11
                     /translation="MTILNGPEQSAAASYDSEVPVRGRQPGNIVVKWLTTTDHKTIGTL
                     YLSTSFAFFLIGGVMALLMRAELARPGLQIVSPEQYNQAFTMHGTVMLLMFATPLFAGF
                     TNWIMPLQIGAPDVAFPRLNMFAYWLYLFGSSIAMGGFFTPQGAADFGWFAYTPLSDAI
                     RTPGLGADLWIMGLAFSGFGTILGAVNFITTIVCLRAPGMTMFRLPIFTWNVLLTGVLV
                     LFAFPVLAAALFALEADRKFGAHIYDPSNGGPLLWQHLFWFFGHPEVYIIALPFFGIIT
                     EIIPVFSRKPIFGYMGLVAATISIAGLSVTVWAHHMYVTGGVLLPFFSFMTFLIAVPTG
                     VKFFNWIGTMWKGSLSFETPMLWAAGFLVTFLFGGLTGVILASPPMDFHVSDSYFVVAH
                     FHYVVFGTVVFAMFAGFHFWWPKFTGKMLDERLGKVTFWTLFVGFHGTFLIQHWLGAEG
                     MPRRYADYLAADGFTTLNTISTISSFLLGLSMLPFLYNVWKTARYGKPVGVDDPWGYGR
                     SLEWATSCPPPRHNFLTLPRIRSESPAFDLHHPDIALAEAEAHGVR"
     gene            6455..6835
                     /locus_tag="IE189_RS06650"
                     /old_locus_tag="GCM10010496_13470"
     CDS             6455..6835
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126379.1"
                     /locus_tag="IE189_RS06650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13470"
                     /product="cytochrome C oxidase subunit I"
                     /protein_id="WP_229901106.1"
                     /transl_table=11
                     /translation="MGSAEDRRGTPANEVSGPDDAGARLGNEAEGYLLWQSRIAVAEER
                     ARVFVEPMDWLTTSQRVEIQGHYVTDSLDRARQDLERIAARCVSLRAEYEQRYRKLRLR
                     CVAWTLTVCGGLVVATAVSLTR"
     gene            complement(7018..7836)
                     /locus_tag="IE189_RS06655"
                     /old_locus_tag="GCM10010496_13480"
     CDS             complement(7018..7836)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-128). E-value: 6.4e-10. Score:
                     31.2. Matches aSDomain:
                     nrpspksdomains_IE189_RS06655_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019979946.1"
                     /locus_tag="IE189_RS06655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13480"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_189918801.1"
                     /transl_table=11
                     /translation="MDAELGTALVTGASSGIGAAYAARLAADGWDTVLVARRAQRLEDL
                     ADRLREETGTKVETLVADLSDQEDLTRVARRAAGPDVGFLLNNAGINGYGPFAGLDPAL
                     MTKVLTLNVLAVTALTRAAVPAMLDRGRGTVVNVASQLAFAGSLPPHPLPERAVYAGTK
                     GYVVTFTRTLAAELAGTPLRVQVLCPGLTATEFHRSRGEEPVPGREPSVHDDGGMPVGR
                     VVDASLTALEQGRVVCVPGLSDPAPVADLTRAELGIRTGGAGHGGAHRHD"
     aSDomain        complement(7453..7821)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS06655_PKS_KR.1"
                     /evalue="6.40E-10"
                     /label="IE189_RS06655_PKS_KR.1"
                     /locus_tag="IE189_RS06655"
                     /protein_end="128"
                     /protein_start="5"
                     /score="31.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="GTALVTGASSGIGAAYAARLAADGWDTVLVARRAQRLEDLADRLR
                     EETGTKVETLVADLSDQEDLTRVARRAAGPDVGFLLNNAGINGYGPFAGLDPALMTKVL
                     TLNVLAVTALTRAAVPAML"
     gene            complement(7868..8353)
                     /locus_tag="IE189_RS06660"
                     /old_locus_tag="GCM10010496_13490"
     CDS             complement(7868..8353)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE189_RS06660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010496_13490"
                     /product="hypothetical protein"
                     /protein_id="WP_189918803.1"
                     /transl_table=11
                     /translation="MSVKSYRLDPTHRVVELSGITDADDALAAEQELRALLRRCDTPAV
                     IVDLECEEPPPAVMNLLVRLRRFAERYRVFLCVTARDPQAAQALREAGLERILRVTRTL
                     SQARERTEVCCAAATASPRPPASTVRTRLKVRLYRFVCPDTRGRTPVTSASRPSDVL"
     gene            complement(8916..9926)
                     /locus_tag="IE189_RS06665"
                     /old_locus_tag="GCM10010496_13500"
     CDS             complement(8916..9926)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487776.1"
                     /locus_tag="IE189_RS06665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13500"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_189919499.1"
                     /transl_table=11
                     /translation="MPGGRFPLSVRRRAVPWERQRPTWREARPAVIAQALKRAQARPSG
                     NWYVVGATRDVRADRPLARTVAAREVVVWRDAEGRLVAGPGVCPHLGAPLKDSPVRCGT
                     LVCHWHGLALKGTPFAGWEPLPVHDDGVLVWVRLDDVGGETPLDAPVVPVRPALPGALS
                     AVYVGVGSCEPEDVVANRLDPWHGAWFHPYSFVDLTVVEAPGTGSNEAEGKGEDGFAVD
                     VSFKLAGRLVVPVRAVFTAPEPRTVVMHITEGEGQGSVVETHATPLGPDDRGRPRTAVV
                     EAVVAASDRRGFAVARTMAPALRPLMRAAAGRLWRDDLAYAERRWHLRSTGRFPG"
     gene            complement(10001..11032)
                     /locus_tag="IE189_RS06670"
                     /old_locus_tag="GCM10010496_13510"
     CDS             complement(10001..11032)
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607879.1"
                     /locus_tag="IE189_RS06670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13510"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_189918805.1"
                     /sec_met_domain="phytoene_synt (E-value: 3e-124, bitscore:
                     408.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 6.2e-66,
                     bitscore: 217.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRELDAAGITDPALRDAYTRCRRLNARHGKTYFLATRLLPVER
                     RPAVHALYGFARWADDIVDSLDATLTTEGRAADLDRLRTRLEHGLQGGDATDPVVLAVA
                     DTAERYGIDHRHFADFMISMRSDLEVTDYPTYADLRTYMHGSAAVIGLQMLPVLGTVVP
                     REEAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLAAHGVDRELLHWSRRTGRR
                     DPRITEALRAVEDLTRGVYREAAPGLAMLDPVSRPAIRTAFVLYGGILEAIAADGYTVV
                     HRRAVVPRRRRAVVALDGLVRVAAARTGSRVTGSRPVALRAPRRPAAGATGHSPEHLHE
                     EVA"
     gene            complement(11029..12570)
                     /locus_tag="IE189_RS06675"
                     /old_locus_tag="GCM10010496_13520"
     CDS             complement(11029..12570)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007496678.1"
                     /locus_tag="IE189_RS06675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13520"
                     /product="phytoene desaturase"
                     /protein_id="WP_189918808.1"
                     /sec_met_domain="DAO (E-value: 1.9e-18, bitscore: 62.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTIPGRTDHVVVVGAGLSGLSAALHLLGAGRRVTVVERDRLPG
                     GRAGLLERGGYRIDTGPTVLTMPELADEAFAAVGDSLYDRVDLIPLHPAYRARFADGSS
                     LDVHTGAEAMEEEVRRFAGADEAAGYRRLRGWLEGLYRAQMRRFIDVNFDSPWQLLTPD
                     LARLAALGGFGRLDAGIGRYLKDERLRRVFSFQALYAGVPPARALAAYAVIAYMDTIAG
                     VHFPRGGMHAVPQAMADAAAEAGADLRFGQDVTRLERSGDRITAVVTAEERIPCDAVVL
                     TPDLPVTYRLLGRAPRRPLRIRHSPSAVVLHAGTDRTWPELAHHTLSFGAAWRSTFEEL
                     TRTGELMSDPSLLITRPTATDPGLAPPGHHLHYILAPCPNTDIGPGAAAWGDLAPRYRD
                     SVLKELEQRGLDGIGSAIEEECLITPADWQAQGHAAGTPFSAAHTFAQTGPFRPRNLVR
                     GTENAVLAGCGTTPGVGVPTVLLSGKLAAARVTGRTTRTPRPASAPRATPEGTPS"
     gene            complement(12567..13958)
                     /locus_tag="IE189_RS06680"
                     /old_locus_tag="GCM10010496_13530"
     CDS             complement(12567..13958)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670292.1"
                     /locus_tag="IE189_RS06680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13530"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_189918810.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.6e-53, bitscore:
                     175.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPSKAKDHHAAVPQPPGPSHASRQTSAAGTHPRPVDFGASPGSL
                     PEGAVGVPLLPDVSDLRVVDDDVPAAVGRLLGELLAERTAQAAVLDQVFAHDLAERVAR
                     FTLDGGKRTRSQFVWWALRACGGEGRAAAAALRVGAALELIQTCALVHDDVMDGSRLRR
                     GRPALHADVETQYAAVAPTAQDARFGEAAAILAGDLALAWADDVLADTELAPDTARRVR
                     GVWSAMRMEMVAGQYLDLQGQITSSRSSARAVRAACLKSALYSVERPLALGAALAGADA
                     ATTAALCSAGRCVGIAFQLRDDLNDVFGSATRTGKASGDDIRSGKPTYLVAVAQARAEA
                     AGDRGALSVLRRSLGRADLSETGLAEVRGVLVATGAREAVEARIERLAVQGMRHLDSVT
                     LRGDGRLRLRALLRSAAGAPPAGRTPYGPSDTAAPSDPPVDRTAAAGGPSGSLLLTAGA
                     EGATR"
     gene            14429..15622
                     /locus_tag="IE189_RS06685"
                     /old_locus_tag="GCM10010496_13540"
     CDS             14429..15622
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982459.1"
                     /locus_tag="IE189_RS06685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13540"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_189918812.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 5.9e-108,
                     bitscore: 356.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDADVAIVGAGAAGLSLAHRLAHRAPATRRLSVVLVDAPPGPLR
                     PPSRTWCFWERGRGRYDAAVTATWRRLRVRTPGGAVIEDDITPLRYKMIRSEDFESLVE
                     HDLGRSGQVRRIEAAVETVEGVPEGARVLARTADGHPLTLRARWVFDSRPLGSLPAART
                     TLLQHFHGWFVRSDRPVFDAGTVELMDFRMPQPASGLSFGYVLPTGDRQALVEYTEFSP
                     HLLSRSGYESALRHYTEDVLGLTGLEVVSTETGVIPMTDAPFARQTAPCVFRIGAAGGA
                     TRPSTGYTFAAVQRQTGAVAQALAAGRRPVPPPAHSARSRAMDAVMLRALDSGRVDGAD
                     FFAHLFTRVPMERLLRFLDGRTRLHEDLSVGVRTPVLPMLRSAAELPYLPRRPFPGP"
     gene            15666..16397
                     /locus_tag="IE189_RS06690"
                     /old_locus_tag="GCM10010496_13550"
     CDS             15666..16397
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888662.1"
                     /locus_tag="IE189_RS06690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13550"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_189918814.1"
                     /sec_met_domain="PCMT (E-value: 1.1e-05, bitscore: 20.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLRDADLAAAFDLAARSYDTLVAANPGYHAHLRRSARRLGLPD
                     GGHGMRVLDLGCGTGASTAALAAVLPGAEITAVDASAGMLERAAAKPWPDNVTFVRASA
                     EGLARAGVEGPFDAVFAAYLFRNAADPDAVLATVRDLLGPHGRLAVHEYTLSGRAAHRA
                     VWTAVCGGFVLPVATALGDGRLYRHLWRSVVDFDTAGEFAARVRAAGFDHVRVLPLPGW
                     QTGITHTFVARRELLDTAGDR"
     gene            16394..17953
                     /locus_tag="IE189_RS06695"
                     /old_locus_tag="GCM10010496_13560"
     CDS             16394..17953
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998484.1"
                     /locus_tag="IE189_RS06695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13560"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_189918816.1"
                     /sec_met_domain="DAO (E-value: 7.3e-11, bitscore: 37.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRATERPAAARRGRDRRARMLTPRPGAPRVRGDHPPTTAVVGGGI
                     AGLAAATALAERGVRVTLLEREPALGGRLAGQSVKLNDGSTVTMSRGFHAFFRQYYNLR
                     GLLRRTDPGLTRLTGLPDYPLRHSSGLHDSFRRVPRTPPWSALGFVALSPTFGLRDLAR
                     MNPVAALPLLDVRVPEVYERLDGVSAHDFLHSVRFPEAAHHLAFEVFSRSFFADPRELS
                     AAEMVLMFHIYFLGSAEGLLFDVPDEPFPDALWEPLAGYLRGHGAELRTSTAVESVEPT
                     ADGGHVVATRDGEQRYDAVVLALDTAGLRSVVGSSPRLADEAWRERVALLRNAPPFLVS
                     RLWLDRPVASDRPGFLGTSGFGTLDNVSVLERWEGEAARWAARTGGSVVELHAYALPEG
                     AARDVEQKRLVERLHDVYPETRAARIVDERHEWRADCPLFPVGGYAARPTVRTVDPGLV
                     VAGDLVRTELPVALMERAATSGFMAANALLERWGVRGQTLWTVPDRGYSPALRALARWG
                     ST"
     gene            18104..18583
                     /locus_tag="IE189_RS06700"
                     /old_locus_tag="GCM10010496_13570"
     CDS             18104..18583
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020137229.1"
                     /locus_tag="IE189_RS06700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13570"
                     /product="glyoxalase/bleomycin resistance/extradiol
                     dioxygenase family protein"
                     /protein_id="WP_189918818.1"
                     /transl_table=11
                     /translation="MTENAVHAEIPDRYRYAVVPHIMVDDAAAAIDFYRRAFGAREDFR
                     IDAPGGGILHAEITVGRSVLMLGDAGGGEGPSAFTAPASLGGTSVALHVHVPDVDGLAE
                     RATAAGAELLQPPTDMFHGDRTAVLRDPSGHLWIFLTHVEDVPPEELARRLAAAG"
     misc_feature    18647..18660
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.74"
                     /tool="antismash"
     gene            18753..20843
                     /locus_tag="IE189_RS06705"
                     /old_locus_tag="GCM10010496_13580"
     CDS             18753..20843
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025229.4"
                     /locus_tag="IE189_RS06705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13580"
                     /product="FG-GAP-like repeat-containing protein"
                     /protein_id="WP_189918819.1"
                     /transl_table=11
                     /translation="MAATVLALGASVVSAGNAVAGPGGARAAEDVVITLGTRDGAVVPP
                     EGLTLSGGRLHVTGRPDDAGRRSLYEYDLAVTGVPTAGPRRLAVDDFWNAYPCPGEPGS
                     SCSEFDARLWGLGDGRIAYQDPSGVHRSVGGTRAPKQRDLQWGHDEDRLTSAAGRYIAV
                     YDGFHTRVGDLDGDPEAQYIAEGRPASVWGTTVWVRGERPGTVKSFEIKSRTESADLDL
                     GTGCTAEELQVVGRWLYWRCPSVARAGVWDFATGRNIAVPSQDGVRMGDGFLVWHEPAV
                     SRMELLDFHRGGGFPYVEKTFVSGVPAGPWDVDRFGGHVAFTDTDGRIHLRSVTVPRRP
                     VAVTDSSVDNGWGPWEGDWRLSRPAASWTLTVKDPYGNLVKEIRGRTREGASVQTGWDG
                     SDADGVPAASGAYTWTLGVDSGDGTGERELTSGALTLTREGGGRSAFRDTDADGYGEMF
                     SMTSAGKLALHHLSRDNGSWTSTGWDTRTRFVSAGDLTGDGCGDVVARTPDGDLWRYAP
                     GCGSPVTPTTPRTLVGAGWAGFDVIVPAADDDGQFRTPDLIARQASTGRLYLYPGHVGV
                     TGYGRPVLIGSGWNGCTILGAADLTGDGFGDLVARDSGGEVWRYDGLGGGRFLPRKLLL
                     SDWGAGRREMFVAGDVTRDGYPDLVSRHADGRLLLNKGNAAGSFGATVRIGTGWGAYTR
                     LY"
     gene            complement(20939..21349)
                     /locus_tag="IE189_RS06710"
                     /old_locus_tag="GCM10010496_13590"
     CDS             complement(20939..21349)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013006040.1"
                     /locus_tag="IE189_RS06710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13590"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_189918821.1"
                     /transl_table=11
                     /translation="MSDFDTSAAPADVVRRQYLASAAGDLTALRATLAPDVEWTEMAGF
                     PLAGTYRTPDGVTSNVMEQLGKDWEGWTAHDDTYVVDGENVVVLARYTATNRATGKPVD
                     VRVAHHFVVRGGLIVRFEQFVDTALVRAAMPN"
     gene            complement(21351..22157)
                     /locus_tag="IE189_RS06715"
                     /old_locus_tag="GCM10010496_13600"
     CDS             complement(21351..22157)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010353062.1"
                     /locus_tag="IE189_RS06715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13600"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_189918823.1"
                     /transl_table=11
                     /translation="MSTLSFKVLDLDFPAGSKNKTATLVTGEEEALLIDAAFTRADGHR
                     LAAEVLDSGKKLTTVFVSHADPDFYFGAEVVADAFPEARFVATPLVIEHIRDSYEGKLK
                     AWAALGPNLPTRLVEIEPLTGDLTLEGHRFELKGGPAALADRHYLWQADHRALLGGVLL
                     FQQEHVWVADTPTPGDRAAWIGLLDEMAALEPDLVVPGHRLPGTAADASAIAATRAYLL
                     AFEEELGRTADGAALTEALVGRYPGNGMLIAAQIGAKVAKGEMKWG"
     misc_feature    complement(22128..22142)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            complement(22193..22819)
                     /locus_tag="IE189_RS06720"
                     /old_locus_tag="GCM10010496_13610"
     CDS             complement(22193..22819)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474103.1"
                     /locus_tag="IE189_RS06720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13610"
                     /product="DsbA family protein"
                     /protein_id="WP_189918825.1"
                     /transl_table=11
                     /translation="MKLIYVFDAYCGWSHGFSGTLREVLARHPELPVDVISGGLFTSQR
                     RVPMRGFAHIGSANAEIGRQTGARFGEPYRRLAAEGSFVMDSEAAARGLAALRHGAPDR
                     AAELAVALQRAFFHDGRSLSAPGTYRELAHAAGLDADRVVASFEGPTARAEAEADFARA
                     AALGVGGFPTLLAVDGPRTVTLARGYATPDEVDRRLASLGATHAS"
     misc_feature    22886..22900
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.77"
                     /tool="antismash"
     gene            complement(23066..23560)
                     /locus_tag="IE189_RS06725"
                     /old_locus_tag="GCM10010496_13620"
     CDS             complement(23066..23560)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474101.1"
                     /locus_tag="IE189_RS06725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13620"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_189918827.1"
                     /transl_table=11
                     /translation="MDEQAGITTAKEAADHELILAFGRLQGAANRLEYILGRALEVECG
                     ISHLMFEVLLILGRAGAPGLPMRAVAQEQVLTTGGATRLVDRMEAAGLVARAESPEDRR
                     GKLVTLTALGEETAVRASRVHVENIKRYFVEPLPAGDRERFAEDLRILSHSARDTLPRL
                     P"
     gene            complement(23640..24653)
                     /locus_tag="IE189_RS06730"
                     /old_locus_tag="GCM10010496_13630"
     CDS             complement(23640..24653)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006383258.1"
                     /locus_tag="IE189_RS06730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13630"
                     /product="hydroxyacid dehydrogenase"
                     /protein_id="WP_189918829.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3.5e-47, bitscore:
                     155.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHSASPVALFAMDPVHLGGLFPPAVMERLRQLAEIDPEFVVRDF
                     SDPAAAVALARAEVLITGWGCPHLGAEVLEAAPRLRTVLHAAGSVRQLVGDPFWERGLT
                     LSSAVQANALPVAEYTLAAILLAGKDAFGLRERLRTERAHPGPAEYAKVGNLGRRVGIV
                     GASRVGRRVLELLRPFDFSVNLYDPYVDAAQAADLGAVSLPLDELLRTSDIVSVHAPDI
                     PQTRHMLSRERLALIPDGGVLINTSRGALVDQNALVGELTGGRLSAVLDVTDPEPLPAD
                     SPLFDLPNVFLTPHIAGSLGNELARMGTTVVDELERLVAGRPPAHPVHRAALANSA"
ORIGIN
        1 ccccggtggc cccgcccgcc ccgatgagca gcagtccggc gacgagcgcg cccgccaggg
       61 tccccacgac ggccgcgcgg acggcggacc aggcggcgac cgcggtggtc cgccccaggg
      121 tcagtacggt cagcagcacc cagaagccgt gcgagaggtc gagcgagccc gccacgagac
      181 gggccagcgc cagaccgcac gcgctgcgca tcgcgttctg gaagacgacc gaacgccgtg
      241 tcagattgcc gtcgagccgg acgaggaaca ggcggaccgt cgaagtccgc gcgtaccaga
      301 actgctcacg gggcaggccg tacaccggcc ggcggccccc gtacgccagg tcgacggccg
      361 tacggacggt cacggccgag accgccacgg tcagcaccgt ggactgccac cgcagcaccc
      421 ggtgcgcgcg ggggacacgt gcgcccggcg gaccgtcccg agaggcccgg aactgggcga
      481 tcatctcctc gatccgctcg ggaccggtcc ccgggcgcgc ccggcgcagc gcgtcggccg
      541 tctcggcgca cgcggccgcc acaccgcgca ggagctcctg cgaggccagg tccccgggta
      601 ccggccgcat ctcggtgagg gcggccagct ggtccacgag ccgccgggtc gcggagccgg
      661 cctgcgccag cgcccggtcc gtccgccccg caccggtcgg ccgcgaaccg gccggctgct
      721 gcgagaagcg cagaccgcgg ccggccgccc tcagccgtcc ggccgtcccg ggccccgggg
      781 gcccgccgcg gaccagcgag cgggcggccc ggtcggcgag gccgagcgtg tcggcgatcc
      841 tcgcgcggta cggcggatcc ggcgggtccg ggaagaccgc cacctcgcac aggacgagcg
      901 ccgccccgcc cagggcgacc ccggccaacc gctgggggag cgtgtccggg gcgaagggcg
      961 ggaagcaggc caggatgtag aacagttcga ggccggggac ggtacccgcc agccgcggcc
     1021 cgcacacggc gccgaacgtc agcacgaacc cgacgaccag catgcccgcg acggccgacc
     1081 aggtgtccac ggcgagggcc gtccccgcga cggtgaggac ggcggcggcc ggccaggcgc
     1141 gcagcaccgt cgcggcccgc ctgcggcctg gccccggcac gggggagagc acaccgaacg
     1201 cgatgggcgt gaacagggcg tatacggccg tcaccggctg atcgagcagg tacgccgccg
     1261 gatagaaccc ggccgccgcg gcggccgaca cacgcgcggc acgccggccg gcccccacgg
     1321 tttctgcgag cgacggccgt tcggccatca gcgctcctcc cgagatcgtc cgcggcttcc
     1381 agtgtcgcgc gggccgggtg atcacgcagg tgggcgccgt cctgccgggg ccggcccccg
     1441 tgaccgcggg cacgagcggg accgggcgcg ggcaaacgga gatcgacagc ccttcgcggg
     1501 gtaggcgagg aacaggaccg aggaatcagg acccagtgct ccatgcccat gacccaggat
     1561 gcgaggaaag gaagacgatg acgacgtacg tgatcaccgt gcccggcacc ttcacggccg
     1621 aggtcggtca ggagacgcgc gcccggctcg gtcgggccct gcgcccggtc gatccgcacc
     1681 acacgcggat gggcagcgag caggacctcg accccctgac cgtgaacgag gacgacacct
     1741 tcacgatccg gctcgccgtc gacgcggaca gcgcccccct cgcggaggag gacgcccgcc
     1801 ggctcgctga ctcggccctg cgcgccgtcg gcctggacga caccgaggcg ccgctgggac
     1861 ccgcggtcgt caccggcatc gactccgacc tctgaagcct ggccgaagcc gcgggaggag
     1921 gcggccgcag accgggcgcg ggccggcggt cagcggccgc ctcgcccgtg ggccaggcgc
     1981 tgccacaccg cccccgccat ggccgcctcg cccttggcgt tggggtgcgc gggggccgcc
     2041 ggagacgtgg gctgcaacgg ttcgatccac cggtcggccg gcgacttgca catgtcgtgg
     2101 ccgatggtgg gaccgtaggt gtcgacgtac tccgcgtggt tccagcgggc caccagacgg
     2161 agcatcaggt tgaggtgctt gccggtgtcc cgcaggtagg ggaagtcccg ggtcgcgaac
     2221 ggcaccgtgg gcgcgcagcc gctgccgtcg tcgggcagca ggtcggggta gccgacgacg
     2281 aggatccggg cgtgcggggc ccgctcgtgc acggcgcgca ggaccttgga gaccttgggc
     2341 gccgtccggg cgatggccag ggtgaggtgg tcgaccccgg aggcgccgta gtgacgctgg
     2401 cacgggttgc cggtcgggtc ctgcggggcg agctgcgcac aggtgccgat gatcgagccg
     2461 aaaccgatgt cgttgccgcc gatctggacg gtcacgaggt cgctcttgcg gtccaccgcg
     2521 tcgagctggg gcccgttggt cccctgcgcc ttccacatct gttcggtcgt ggccccgccg
     2581 cagctgacgt ccttgaagcc ggacgccttc agccgcccgg ccacgatcga cgggtaattg
     2641 tggtcggagc gggcgcagtt ggcgtccacc tggcgaggga tgagggggcc cgaggtgtac
     2701 gagtcgccga gggccacata gcgggtgccc ccgcccccac cgctcccgcc gtgcgccgcc
     2761 gcgggcaccg ccgaggccgc gaccagggcg caactgccca gtgccgcgag cagggtgaca
     2821 ctcttccggc cgcgccccac cggtacgccc gtgctcttgc cgcgccgcgc cgagtcccgc
     2881 tgcgtcgaat cccgctgcat cgaggtccct cccccttgaa gtccctggag gcctcggggg
     2941 catggagcag cccccgcagg cccgtgcctc gccgacgacg tcgtcccgta cggccggcac
     3001 gccgtttgcc tgggcttgta taccgcccgg taggtcacct gggccagagc ccggagcgaa
     3061 cgggttgacc atcaggtccc gatgccccgc cacaggttgg cgacgaggct gtccgcgaag
     3121 tcctcgtcca cggggagatt gggcagcagc aggcggtggt aacaggcgcc ccacagctgg
     3181 tccaccacga cctccgggtc gacgtcgggg cgcagccggc cctcggcctg tgccccgcgc
     3241 atccgcagga ccgccaggtc ccgccggggg cccgagtagc gttccagcaa ggcggcggag
     3301 agctcggggt ccgtctgcgc ctggccgatc agctcggcga tcacccgccc ggcgggggtg
     3361 agggtgagta tccgcacgaa cgcgcggagc tgggccgtca ggtccgcccg gaggtcgccg
     3421 gtgtccggga aggccagcgc ggactccacg gcgtggaagt agccgtcgag ggcgagcgcg
     3481 cccttggagg gccaccattt gtagagggtc gtcttgctga ccccggcgcg ttccgcgacc
     3541 gcctcgatgg tgaacgagcc catgcccgcg tcgaggagca ggccgcccgc cgcgtccagg
     3601 acgtccgagc gcacctcggc ggcgggccgg cgcccccggc ccctgcgccg gcgcggtggc
     3661 ggaccggcct cggccggctt ctgggcgtcc tgcacggcgt cctgtgtcac gcctgcctcc
     3721 cgggggtcgt acgagcgacc ttcagcctcg catatggacg cagcgttcac aacatggtta
     3781 tatggactca gcgttcataa acagagtgga ggcacaccat gtccgagatc acgcgcgtcg
     3841 cccttgtcac cggcgcttcc ggggggatcg gccgcgccgt ggcgcgacgg ctcgcggccg
     3901 cgggaacggc cgtcggagtg cactacgcgg gcaacaaggc ggcggcggag gagaccgtcg
     3961 ccgccgtcga ggcggcgggc ggccgggcga tcgcggtcaa cggcgacgtg gccgacgagg
     4021 gcgccatgtc cgacgccttc tccgccgtgg aagaggcgtt cggcggggtc gacgtcgtga
     4081 tccacaccgc cggtgtgatg accctggggc cggtggccgc gttcgacctc gacgcgttcg
     4141 accggctgat gcgcaccaac gtccgcggcg ccttcgtcgt ggcccagcag gcggcccgcc
     4201 gggtccgtga cggtggcgcc gtcgtcacct tctccacctc ggtgacccgg ctcgcgttcc
     4261 ccgactacgc gccctacgcg gcgagcaagg gggcggtgga ggccatgacc ctggtgctcg
     4321 cccgcgagct gcgcggccgg gacatcaccg tcaacgccgt cgcgcccggc ccgaccgcga
     4381 ccccgctctt cctcgacggc aaggaccggc agaccgtcga ccggctcgcc gcacagcccc
     4441 cgctcgagcg cctcggcaca ccggaggaca tcgcggagac cgtcgccttc ctggccggac
     4501 cggggcgctg ggtcaacgga caggtcctct acgtgaacgg cggcatcgcc tgagcagacc
     4561 tgagcggagg tgaggtgttc ccggcggcgg gaggcgcgga cgccggtggc cggccccccg
     4621 gtccggccgg ggattactcc acccgtgggt ggcgatcgcc cgttcggccg tacgccggcc
     4681 gccgtggcac ctccctcgcc acctcgagcc gcgaggatga ccggtgactc acgtcatggc
     4741 gagagcgaac cgcgagcatc agggagaaag acacctgtga ccatcctcaa cggcccggag
     4801 cagtcggccg ccgcctcgta cgacagcgaa gtgccggtac ggggcaggca acccggcaac
     4861 atcgtggtga agtggctgac caccaccgac cacaagacga tcggcaccct ctatctgagc
     4921 acgtccttcg cgttcttcct gatcggcggc gtcatggcgc tgctcatgcg cgccgaactc
     4981 gcccggccgg gtcttcagat cgtctcgccc gagcagtaca accaggcgtt cacgatgcac
     5041 ggcaccgtga tgctgctgat gttcgccacc ccgctcttcg ccggtttcac caactggatc
     5101 atgccgctcc agatcggcgc cccggacgtc gcgttcccgc ggctgaacat gttcgcctac
     5161 tggctgtacc tgttcggctc gtccatcgcc atgggcggct tcttcacccc gcagggcgcc
     5221 gccgacttcg ggtggttcgc ctacaccccg ctgtcggacg cgatccggac gcccggactc
     5281 ggcgccgacc tgtggatcat gggcctggcg ttctccggct tcggcaccat cctgggcgcg
     5341 gtcaacttca tcaccacgat cgtctgcctg cgcgcgcccg gcatgacgat gttccggttg
     5401 ccgatcttca cctggaacgt cctgctgacc ggtgtcctgg tcctgttcgc cttccccgtg
     5461 ctggcggccg cgctgttcgc cctggaggcg gaccgcaagt tcggcgccca catctacgat
     5521 ccgtccaacg gcggccccct gttgtggcag cacctcttct ggttcttcgg ccacccggag
     5581 gtgtacatca tcgccctgcc gttcttcggc atcatcaccg agatcatccc ggtgttctcc
     5641 cgcaagccga tcttcggcta catgggcctg gtcgccgcca ccatctccat cgcgggcctc
     5701 tcggtcaccg tgtgggcgca ccacatgtac gtcacgggcg gcgtgctgct gccgttcttc
     5761 tccttcatga cgttcctcat cgccgtcccg acgggcgtga agttcttcaa ctggatcggc
     5821 acgatgtgga agggctcgct gtcgttcgag acaccgatgc tgtgggccgc gggcttcctg
     5881 gtcacgttcc tcttcggtgg tctgaccggc gtcatcctgg cctcgccgcc gatggacttc
     5941 cacgtctcgg actcgtactt cgtggtggcg cacttccact acgtcgtctt cggcaccgtc
     6001 gtcttcgcga tgttcgcggg cttccacttc tggtggccga agttcaccgg caagatgctc
     6061 gacgaacgcc tcggcaaggt caccttctgg acgctgttcg tcggcttcca cggcaccttc
     6121 ctgatccagc actggctcgg cgccgagggc atgccccgcc ggtacgccga ctacctcgcg
     6181 gccgacggct tcaccaccct caacaccatc tcgacgatca gctcgttcct gctcggtctg
     6241 tcgatgctcc ccttcctcta caacgtgtgg aagaccgccc ggtacggcaa gccggtcggc
     6301 gtcgacgacc cgtggggtta cggccgctcc ctggagtggg cgacgtcgtg cccgcccccg
     6361 cgccacaact tcctcaccct gccccggatc cgcagcgaat cgcccgcgtt cgacctgcac
     6421 caccccgaca tcgccctggc cgaggccgag gcccatgggg tccgctgagg accggcgggg
     6481 gacacctgcg aacgaggtgt ccgggccgga cgacgcgggg gcccgcctcg ggaacgaggc
     6541 cgagggatac ctcctgtggc agtccaggat cgccgtggcc gaggagcgcg cgcgtgtgtt
     6601 cgtcgagccg atggactggc tgaccacctc gcagcgcgtg gagatccagg gccactacgt
     6661 caccgacagc ctcgaccgcg cccgtcagga cctggaacgg atcgccgccc gctgcgtgtc
     6721 cctgcgcgcg gagtacgagc agcgctaccg gaagctgcgg cttcgctgcg tggcgtggac
     6781 gctgaccgtg tgcgggggac tggtcgtcgc cacggccgtg tcactgaccc gctgacccgg
     6841 ctcccgcccg ggccccacgg cttcgatccg tcggcggtcg cgccgcggca ggcgcgggcc
     6901 tgaggaccgt ggaccttgga cccgacgtgg tccccccgtc cgcgggggac ccgccgcgca
     6961 tggatctctt cagccgcccc ctcgtggacg gcttcgactg acgcggggct ccgcgcttca
     7021 gtcgtggcgg tgcgcgccac cgtgtccggc tccgccggtg cggattccca gctcggccct
     7081 ggtcaggtcg gcgaccggcg cggggtcgga gagccccgga acgcagacca cccgcccctg
     7141 ctccagggcg gtcagcgagg cgtcgacgac ccggcccacc ggcatgccgc cgtcgtcatg
     7201 gacggacggc tcccgcccgg ggacgggctc ctctccgcgc gagcggtgga actccgtcgc
     7261 cgtcagaccc gggcacagca cctggacgcg caacggcgtc ccggccagct cggcggcgag
     7321 ggtacgggtg aacgtgacca catacccctt ggtgccggcg tagacggcgc gctcgggcag
     7381 cggatgcggt ggcagggagc cggcgaaggc gagctgcgaa gccacgttga cgacggtgcc
     7441 ccgtccccgg tccagcatcg ccggaaccgc cgcgcgggtc agcgcggtca ccgcgagcac
     7501 gttgagggtc aggaccttgg tcatgagcgc ggggtcgagt ccggcgaaag ggccgtagcc
     7561 gttgatgccc gcgttgttga gcaggaatcc cacgtcgggg ccggccgccc gccgcgccac
     7621 acgggtcagg tcctcctggt ccgacaggtc ggcgaccagg gtctccacct tcgtccccgt
     7681 ctcctcgcgc agccggtccg cgaggtcctc cagccgctgc gcccgccggg ccaccagcac
     7741 ggtgtcccag ccgtcggcgg ccaaccgggc ggcgtaggcc gcgccgatcc ccgacgacgc
     7801 tcccgtcacc agcgccgtgc cgagttccgc gtccatccgt ccctcgccct ctcgtcgcgt
     7861 acgggcctca gagcacgtcg gacgggcggg acgccgacgt cacgggcgtc cgccccctcg
     7921 tgtcggggca gacgaaccgg tagagccgca ccttgaggcg ggtgcggacc gtggacgccg
     7981 gggggcgggg tgaggccgtc gccgccgcac agcacacctc ggtccgttcc cgggcctgtg
     8041 acagcgtgcg ggtgacgcgc aatatgcgct ccagaccggc ctcgcgcagc gcctgcgcgg
     8101 cctgcgggtc gcgtgccgtg acacacagga agacgcggta ccgctccgcg aaccggcgca
     8161 ggcgcaccag gaggttcatg acggcgggcg gcggttcctc gcactccagg tccacgatga
     8221 cggcgggggt gtcgcaacgt cgcagcaagg cccgcagttc ctgttcggcg gccagcgcgt
     8281 catcggcatc ggtgatcccg ctcagctcga cgacccggtg ggtcgggtcg aggcggtagc
     8341 tcttcacaga caaggcccac ttcccggcag aaacaggaca tccagcgcgt cctgaccagc
     8401 cttacgcctg cccctttcca cgccccccac acgcccccga cggcacgggc cgcaccgatc
     8461 gctcccgccg cgaccgcggg gccgcgaggc ccgccatgcc cggccgccgt ctgccggtgt
     8521 cctgtcgccc ggccgtcccg gagcgtcggc ccggggacgc cgggccacgg ccgccgaggg
     8581 cgtcgcgccc gccgacgtgc cgtgcccatc ggcccggctg tgctcgccgt ccggctgcgg
     8641 cttgccccgg ccaggggcgc cgtccggccg ccgtggccgc cgtccgaccg cgccccgcgc
     8701 gagcgctgcc gtcgagccgt gactcgcgtg accgccgagg tcgtccggcc gtgcccgcac
     8761 aatcgccgtc gtcgggccgt gccccgcgcg ggcgccgccg ctcggacgtg tccgggggtg
     8821 accgtcgccg ggacgcgacc ggactcgcgg tggtcgggac gacggggacc cgtcgtcccg
     8881 gccgcgctgc ccgcccggtg gtgctgccgc tgggttcagc ccgggaagcg gcccgtggag
     8941 cgcaggtgcc agcgccgttc ggcgtaggcc aggtcgtcgc gccacaggcg tccggcggcg
     9001 gcccgcatga gcggccgcag ggccggggcc atcgtgcgcg cgacggcgaa gccgcggcgg
     9061 tcggaggccg ccacgacggc ctcgacgacg gcggtccgcg gcctgccccg gtcatcggga
     9121 ccgagcggcg tcgcatgggt ctcgacgacg gagccctgcc cctcgccctc ggtgatgtgc
     9181 atgacgaccg tacgcggctc cggcgcggtg aacacggccc gcaccgggac gacgagccgc
     9241 ccggccagtt tgaaggagac gtcgacggcg aacccgtcct cccctttccc ttccgcctcg
     9301 ttgctcccgg ttcccggcgc ttcgacgacg gtgaggtcga cgaaggagta ggggtggaac
     9361 caggcgccgt gccaggggtc gagccggttg gcgacgacgt cctccggctc gcagctcccg
     9421 acgcccacgt agacggccga cagcgcgccc ggcagcgccg gccggaccgg caccacaggt
     9481 gcgtcgagcg gggtctcgcc gcccacgtcg tcgagccgga cccacaccag gacaccgtcg
     9541 tcgtggacgg gaagcggttc ccagcccgcg aagggcgtgc ccttcagggc gagtccgtgc
     9601 cagtggcaga ccagcgtgcc gcagcgcacg gggctgtcct tcagcggcgc gcccaggtgc
     9661 gggcagacgc cgggcccggc gacgagccgg ccctcggcgt cgcgccagac gaccacctcc
     9721 cgtgcggcga cggtgcgcgc gagcggccgg tcggcgcgga cgtcacgggt ggcgcccacc
     9781 acgtaccagt tgccggaagg gcgggcctgc gcccgcttca gcgcctgggc gatcacggcg
     9841 ggccgggcct cgcgccaggt ggggcgctga cgttcccacg gcacggcacg ccggcgcacg
     9901 gacaacggga accggccgcc cggcatgcga cggcccgcgc ggccggaggg cccgggaaga
     9961 cggcccaagg gcccaggacg gcggccggaa ggctcggtgc tcacgcgacc tcctcgtgaa
    10021 ggtgctcggg cgagtgcccg gtcgcccccg ccgccggtcg gcgaggggcc cggagcgcga
    10081 ccggccggga acccgtgacc cgtgacccgg tccgggccgc ggccacgcgc accaggccgt
    10141 cgagggccac gacggcacgg cgccgccggg gcaccacggc gcgccggtgc accaccgtgt
    10201 acccgtccgc ggcgatggcc tccaggatgc ccccgtacag cacgaaggcc gtccggatcg
    10261 ccggacggga caccgggtcg agcatggcca ggcccggcgc cgcttcccgg tacaccccgc
    10321 gcgtgaggtc ctcgacggcc cgcagcgcct cggtgatgcg ggggtcgcgg cggccggtgc
    10381 gccggctcca gtgcagcagc tcacggtcca cgccgtgggc ggccagcagg tcggccggca
    10441 ggtagacgcg gccgcggtcg aggtcctcgc ccacgtcccg caggaagttg gtcagctgga
    10501 aggcgacgcc gagggcggcc gcgtgcggcg cggcctcctc gcgcgggacc accgtgccga
    10561 gcaccggcag catctggagt ccgatgaccg ccgccgagcc gtgcatgtac gtccgcagat
    10621 cggcgtaggt cgggtagtcg gtgacctcga gatcgctgcg catggagatc atgaagtcgg
    10681 cgaagtgccg gtggtcgatg ccgtaccgct ccgccgtgtc ggccaccgcg aggaccaccg
    10741 ggtcggtggc gtccccgcct tgcagcccgt gctccagtcg cgtgcgcaga cggtcgaggt
    10801 ccgcggcacg gccctccgtc gtgagggtgg cgtccaggga gtcgacgatg tcgtccgccc
    10861 agcgggcgaa gccgtacagg gcgtgcacgg cgggccggcg ttcgaccggc agcagccggg
    10921 tggcgaggaa gtacgtcttg ccgtgccggg cgttgagccg acggcagcgc gtgtaggcgt
    10981 cacgcagcgc cggatccgtg atgcccgccg cgtcgagttc gcggtcggtc atgagggcgt
    11041 tccttccggg gtggcccgcg gcgcggacgc cgggcggggg gtacgggtcg tgcgtccggt
    11101 gacgcgggcc gcggcgagct tgccggacag caggacggtc ggcacgccca ctccgggtgt
    11161 ggtgccgcaa ccggcgagca cggcgttctc ggtgccccgc accaggttgc gggggcggaa
    11221 cggaccggtc tgggcgaagg tgtgggccgc ggagaacggc gtgcccgccg cgtggccctg
    11281 tgcctgccag tcggccggtg tgatcaggca ctcctcctcg atcgccgagc cgatgccgtc
    11341 caggccgcgc tgctccagct ccttgaggac gctgtcgcgg tagcgcggcg ccaggtcgcc
    11401 ccacgcggcg gcgccgggtc cgatgtcggt gttggggcag ggcgcgagga tgtagtgcag
    11461 gtggtgtccg ggcggggcga gtccggggtc ggtggccgtc gggcgggtga tgagcagcga
    11521 cgggtcgctc atcagctcgc cggtccgggt cagttcctcg aaggtgctcc gccaggccgc
    11581 gccgaacgac agcgtgtggt gggccagttc gggccaggtg cggtcggtcc cggcgtgcag
    11641 gacgacggcc gaaggggagt gccggatccg caggggccgt cgcggggccc gcccgaggag
    11701 gcggtaggtg acgggcaggt cgggggtgag gacgaccgcg tcgcacggga tgcgctcctc
    11761 ggcggtcacg accgcggtga tgcggtcgcc ggaccgctcc agccgggtga cgtcctgccc
    11821 gaaccgcagg tcggcgcccg cctccgccgc ggcgtccgcc atcgcctgcg gcaccgcgtg
    11881 catgccgccg cgcgggaagt ggacgccggc gatcgtgtcc atgtaggcga tgacggcgta
    11941 ggcggccagc gcccgggccg gcggtacgcc cgcgtacagg gcctggaagg agaagacgcg
    12001 gcgcaggcgt tcgtccttga ggtaccggcc gatgcccgcg tcgagccggc cgaagccgcc
    12061 gagggccgcc agccgggcca gatcgggcgt cagcaactgc cagggggagt cgaagttgac
    12121 gtcgatgaag cggcgcatct gggcccggta gagcccctcc agccagccgc gcagacgacg
    12181 gtacccggcg gcctcgtcgg cgccggcgaa ccgcctgacc tcttcctcca tcgcctcggc
    12241 gccggtgtgc acgtcgagac tgctgccgtc ggcgaaccgg gcccggtagg ccgggtggag
    12301 cgggatcagg tcgacccggt cgtacaggct gtcgccgacc gcggcgaacg cctcgtcggc
    12361 gagttccggc atggtcagca cggtggggcc ggtgtcgatg cggtagccgc cgcgctcgag
    12421 gaggccggcc cgtccgccgg gcagccgatc gcgctcgacg acggtgaccc gccgccccgc
    12481 cccgagcagg tgcagcgcgg ccgacagccc ggacagaccg gcgccgacca ccacgacgtg
    12541 gtcggtgcgg ccggggatcg ttctggtcat cgggtggccc cttcggcgcc ggcggtgagc
    12601 agcagtgagc cggacgggcc gcccgcggcc gcggtccggt cgacgggcgg gtcggacggg
    12661 gcagccgtgt cggacgggcc gtacggcgtg cgtccggcgg gcggggctcc cgccgccgag
    12721 cgcagcagtg cgcgcagacg cagccgtccg tccccgcgga gggtcacgga gtccagatgg
    12781 cgcatgccct ggaccgccag ccgctcgatg cgggcctcga ccgcctcgcg cgccccggtg
    12841 gcgaccagca cgccccgcac ctcggcgaga ccggtctcgg acaggtcggc ccggcccagc
    12901 gagcgccgca gcaccgacag ggcgccccgg tcgcccgccg cctcggcccg ggcctgggcc
    12961 accgcgacga ggtaggtggg cttgcccgag cggatgtcgt cccccgaggc cttgccggtg
    13021 cgggtcgcgc tgccgaagac gtcgttcagg tcgtcgcgga gctggaaggc gatgccgacg
    13081 caccggccgg ccgagcacag ggcggcggtc gtggcggcgt ccgcgcccgc cagggccgcg
    13141 ccgagggcca gcggccgttc caccgagtac agggcactct tgaggcaggc ggcgcgcacg
    13201 gcgcgggcgg acgagcgcga cgaggtgatc tggccctgga ggtccaggta ctgcccggcc
    13261 accatctcca tccgcatggc gctccacacg ccgcgcaccc ggcgcgcggt gtccggcgcg
    13321 agttcggtgt cggcgagcac gtcgtccgcc caggccagtg ccagatcccc ggcgaggatg
    13381 gccgcggcct cgccgaaccg cgcgtcctgc gcggtgggag ccacggccgc gtactgggtc
    13441 tcgacgtccg cgtgcagggc gggccggccg cggcgcagcc gggagccgtc catcacgtcg
    13501 tcgtggacca gcgcgcaggt ctggatgagt tcgagggcgg cgccgacccg cagcgcggcc
    13561 gccgccgcac ggccctcgcc gccgcaggcg cgcagcgccc accacacgaa ctgcgagcgg
    13621 gtgcgcttgc cgccgtccag ggtgaaccgg gccacgcgct ccgcgagatc gtgcgcgaac
    13681 acctggtcga ggacggcggc ctgcgcggtg cgctcggcca gcagttcgcc gagcaggcgt
    13741 ccgacggccg cgggtacgtc gtcgtcgacc acccgcaggt cgctcacgtc cggcaggagc
    13801 gggacgccga cggcaccttc gggcaggctg ccgggtgacg cgccgaagtc cacgggacgc
    13861 ggatgcgtcc cggcggcgga ggtctgcctg gacgcgtggg acgggccggg cggctgcggt
    13921 acggccgcat ggtggtcctt cgccttgctg gggcgcatcc cggttcctct cgtgtgctcg
    13981 aaagctcgcc ttgtgtagac gcattccgcg ccgacggcga agtcggatgc gccatgcggt
    14041 ggaattgcgg ttgcccgtcc gaggacggga ccggccgcac gacgcgagta acgagtgcca
    14101 cgcacgggcc tccgcctcac ctgccggctc ccacccgcca ccgcgacacc gaccgaacgg
    14161 cggacccgcc ggggcggcac accgtgcccg ggccgcgccg cgccggggca cgagtacggt
    14221 ccgcacgacc gctcggctcc cgcgcgccga gtgaacgccg ttccgacgcg gtcggtatgt
    14281 cgtgcccggt cggctcgtac ggccggccgg cgcctgatcg cacgggtggc cccctgccca
    14341 gcgtggcctg catccgccgg ggcacccggg cgggaatgct tccgacagcg cgcacgccga
    14401 cgcgcccggg gaaaggagtg gagcgctcat gctcgacgcg gacgtcgcca tcgtgggcgc
    14461 gggagccgcg gggctgtccc tggcccaccg gctggcgcac cgcgccccgg cgacccgtcg
    14521 tctctcggtg gtgctggtgg acgccccgcc cggccccctg cggccgccga gccgtacgtg
    14581 gtgcttctgg gagcgcggcc ggggccgcta cgacgctgcc gtgaccgcga cctggcggcg
    14641 gctgcgggtg cgcaccccgg gcggcgcggt catcgaggac gacatcacgc cgctgcgcta
    14701 caagatgatc cgctcggagg acttcgagag cctggtcgag cacgacctcg ggcggagcgg
    14761 acaggtgcgg cgcatcgagg cggccgtcga gacggtggag ggcgtccccg aaggcgcccg
    14821 ggtcctcgcc cgcacggccg acgggcaccc cctcaccctg cgggcccgct gggtcttcga
    14881 ctcgcgcccg ctcggcagtc tcccggcggc ccgcacgacc ctgctccagc acttccacgg
    14941 ctggttcgtc cgctccgacc ggcccgtctt cgacgccggg acggtcgagc tcatggactt
    15001 ccgcatgccc cagcctgcgt cgggcctgtc cttcggctac gtgctgccca ccggcgaccg
    15061 gcaggcactc gtggagtaca ccgagttctc cccgcacctg ctgtcccgga gcggctacga
    15121 gagcgcgctg cgccactaca ccgaggacgt cctcggcctc accgggctgg aggtcgtgtc
    15181 gacggagacc ggcgtgatcc cgatgaccga cgccccgttc gcccggcaga ccgccccctg
    15241 cgtcttccgg atcggtgcgg cgggcggcgc gacccgcccc tcgaccggct acaccttcgc
    15301 cgccgtgcag cgccagacgg gagccgtcgc gcaagccctg gcggcaggac gccggcccgt
    15361 gccgccgccc gcgcactcgg cgcggtcccg ggcgatggac gccgtcatgc tgcgggccct
    15421 ggacagcggc cgggtcgacg gcgccgactt cttcgcgcac ctcttcaccc gggtgccgat
    15481 ggaacgcctg ctgcgcttcc tcgacggccg cacccgcctg cacgaggacc tctccgtggg
    15541 ggtccgcacc cccgtgctgc cgatgctccg ttccgccgcg gagctgccct acctgccccg
    15601 ccgtcctttt cccggaccgt gaccgccccg cgggcgcgct ccgtgccccc atccgaggag
    15661 accgcatgac cctgctgcgc gacgcggacc tggccgccgc gttcgatctc gccgcccgca
    15721 gctacgacac gctcgtggcc gccaaccccg gctaccacgc ccatctgcgc cgctcggcac
    15781 gccgtctcgg gctgccggac ggcggccacg ggatgcgcgt gctggacctc ggctgcggca
    15841 ccggcgcctc gacggccgcg ctcgccgccg tcctcccggg cgccgagatc acggcggtgg
    15901 acgcctccgc cggcatgctg gagcgggccg ccgcgaaacc ctggccggac aacgtgacgt
    15961 tcgtgcgcgc ctcggcggag ggcctggcgc gggcgggcgt cgagggcccg ttcgacgcgg
    16021 tgttcgccgc ctacctgttc cgcaacgcgg ccgaccccga cgccgtactg gccaccgtgc
    16081 gcgacctgct gggcccgcac ggccggctgg cggtccacga gtacacgctc agcggccgcg
    16141 ccgcgcatcg cgcggtgtgg acggcggtct gcggcggctt cgtcctgccc gtggcgaccg
    16201 ccctcgggga cgggcggctg taccgccacc tgtggcgcag tgtcgtcgac ttcgacactg
    16261 ccggcgagtt cgccgcacgg gtccgcgcgg ccgggttcga ccatgtccgg gtgctgcccc
    16321 tgcccggctg gcagaccggc atcacccaca ccttcgtcgc ccgtcgcgag ctcctcgaca
    16381 cggcgggcga ccgatgaggg ccaccgagcg gcccgcggcc gcccgccgcg gcagggaccg
    16441 gcgcgcccgg atgctgacgc cccggcccgg ggcgccgcgg gtccgcggcg accacccgcc
    16501 gacgaccgcc gtcgtggggg gcggcatcgc gggactcgcg gccgccaccg ccctggccga
    16561 gcgcggcgtg cgcgtcacgc tcctcgaacg cgaaccggcg ctcggcgggc gcctggcggg
    16621 ccagtcggtg aagctgaacg acggctccac cgtgacgatg agccgcggct tccacgcgtt
    16681 cttccgtcag tactacaacc tgcgcggcct gctgcgccgg accgatccag gactcacgcg
    16741 gctgaccggc ctgcccgact acccgctgcg ccacagctcg ggcctgcacg acagcttccg
    16801 ccgcgtgccg cgcaccccgc cctggagcgc cctcgggttc gtcgccctga gccccacctt
    16861 cggtctgcgg gacctggccc gtatgaaccc ggtggcggcg ctgcccctgc tcgacgtccg
    16921 cgtccccgag gtgtacgagc gcctggacgg cgtcagcgcc cacgacttcc tgcactcggt
    16981 ccgcttcccc gaggccgcgc accacctcgc cttcgaggtg ttctcccgca gcttcttcgc
    17041 cgacccgcgg gagctgtcgg cggccgagat ggtgctgatg ttccacatct acttcctcgg
    17101 gtccgccgag gggctgctct tcgacgtgcc cgacgagccc ttccccgacg cgctctggga
    17161 acccctcgcc ggctatctgc gcggccacgg cgccgagttg cgcacctcca cggccgtcga
    17221 gagcgtcgaa cccaccgcgg acggcggtca cgtcgtcgcc acccgggacg gggaacagcg
    17281 ctacgacgcg gtcgtcctgg ccctggacac ggcgggtctg cggtccgtcg tcggcagctc
    17341 cccgcggctg gccgacgagg cgtggcgcga gcgggtggcc ctgctgcgca acgcgccgcc
    17401 gttcctggtc tcccgcctct ggctggaccg gcccgtggcc tcggaccgcc ccggcttcct
    17461 gggcaccagc gggttcggaa ccctggacaa cgtcagcgtc ctcgaacgct gggagggcga
    17521 ggcggcccgc tgggcggccc gtaccggcgg ctccgtcgtc gaactgcacg cctacgcgct
    17581 gcccgagggc gcggcccgtg acgtggagca gaaacgcctg gtcgagcggc tgcacgacgt
    17641 gtacccggag acgcgggcgg cgaggatcgt cgacgagcgt cacgagtggc gggccgactg
    17701 cccgctgttc ccggtcggcg gctacgcggc ccgtcccacc gtccggaccg tagatccggg
    17761 cctggtggtc gccggcgacc tggtgcgtac ggaactcccc gtggcgctga tggaacgagc
    17821 ggcgaccagc ggattcatgg cggccaacgc cctgctggag cgctgggggg tccgtggtca
    17881 gaccttgtgg acggtgcccg accgggggta cagccccgcc ctgcgcgcgc tggcccgctg
    17941 ggggagcacc tgaccgggcg gacccgctcg gaccgacccg ctcggacgga ccttgccggt
    18001 ggcgcgctcc gaaggccgtt gacctcgacc gggcttgagc ttctaggttc ccttccggag
    18061 ccgcgggagc cgaccggcgg cgccgtcacc cgggaggtac gccatgaccg agaacgccgt
    18121 gcacgccgag atccccgacc ggtaccgcta cgcggtggtc ccgcacatca tggtcgacga
    18181 cgccgccgcg gccatcgact tctaccggcg tgcgttcggc gcccgcgagg acttcaggat
    18241 cgacgcgccc ggcggcggga tcctgcacgc cgagatcacg gtcgggcgct ccgtgctgat
    18301 gctgggcgac gcgggcggtg gcgaggggcc gtccgccttc accgcgcccg cctcgctcgg
    18361 cggcacctcc gtcgccctgc acgtccatgt ccccgacgtc gacggcctgg cggagcgcgc
    18421 gacagccgcc ggcgccgaac tcctccagcc gccgacggac atgttccacg gcgaccgcac
    18481 cgcggtcctc cgcgacccgt cgggccacct gtggatcttc ctgacccatg tcgaggacgt
    18541 cccgccggag gagctcgcgc gccggctcgc cgccgccggg tgaccgcacg ccggacctcg
    18601 aagggccgga ccgctcccgg gccacacgac tgaggcgccg tcagacatgt acaaccaaaa
    18661 ggcggttcga gtggtcgagg gtgtcaggac gtcgacgtct tcgatggggg accgggatga
    18721 agaactccgg gcacagaatc cgttccgctc tggtggcggc caccgtactg gcgctgggcg
    18781 cctccgtggt gtcggccggg aacgccgtcg ccggacccgg cggcgccagg gcggccgagg
    18841 acgtggtgat caccctgggg acccgtgacg gcgccgtagt gccgcccgag ggcctgacgc
    18901 tgtccggcgg ccggctccac gtcaccggcc gccccgacga cgccggccgg cgcagcctct
    18961 acgagtacga cctcgccgtc accggggtgc cgaccgcggg cccgcgccgc ctggccgtcg
    19021 acgacttctg gaacgcctac ccgtgccccg gcgaacccgg ctcgtcctgc tcggagttcg
    19081 acgcgcggct gtggggcctc ggcgacggcc gtatcgccta ccaggacccg tcgggcgtcc
    19141 accggtcggt gggcggcacg cgcgcgccga agcagcgcga cctccagtgg gggcacgacg
    19201 aggaccggct gacctcggcg gcggggcgct acatcgccgt gtacgacgga ttccacaccc
    19261 gcgtgggcga cctggacgga gaccccgagg cgcagtacat cgccgaaggc cggcccgcgt
    19321 ccgtctgggg gacgaccgtg tgggtccgcg gtgaacggcc cggcaccgtc aagtcgttcg
    19381 agatcaagag ccgcacggag tccgcggacc tcgacctcgg gacggggtgc acggcggagg
    19441 agctccaggt ggtgggccgg tggctctact ggcgctgccc ctcggtcgcc agggcgggcg
    19501 tgtgggactt cgcgacgggc aggaacatcg ccgtcccctc gcaggacggc gtccggatgg
    19561 gcgacgggtt cctcgtctgg cacgaaccgg cggtgagccg gatggagttg ctcgacttcc
    19621 accggggcgg cggcttcccg tacgtggaga agaccttcgt ctccggcgtg ccggcgggac
    19681 cgtgggacgt ggaccggttc ggcggtcacg tggcgttcac ggacacggac ggcaggatcc
    19741 acctccggtc ggtgaccgtg ccgcgccggc cggtcgccgt caccgacagc tccgtcgaca
    19801 acggctgggg cccctgggaa ggggactggc ggctcagccg cccggcggcg tcctggaccc
    19861 tcaccgtcaa ggatccgtac ggcaacctcg tgaaggagat ccgcggacgc acccgcgagg
    19921 gcgcctcggt gcagaccggc tgggacggat ccgacgcgga cggcgtcccg gccgcctccg
    19981 gcgcgtacac ctggacgctc ggggtcgact cgggcgacgg cacgggagag cgggaactga
    20041 ccagcggcgc cctgacgttg acccgggagg gaggcggacg cagcgccttc cgggacaccg
    20101 acgccgacgg ctacggcgag atgttctcca tgacgagcgc cggcaagctc gccctccacc
    20161 acctctcccg tgacaacggc tcctggacgt ccaccggatg ggacacccgt acccgcttcg
    20221 tctcggcggg ggacctgacc ggcgacggct gcggcgacgt cgtggcccgc accccggacg
    20281 gcgacctgtg gcgctacgcc ccgggctgcg gcagccccgt caccccgacc accccgcgga
    20341 ccctggtcgg cgcgggctgg gccggcttcg acgtgatcgt cccggcggcc gacgacgacg
    20401 ggcagttccg cacgccggac ctgatcgccc ggcaggcgtc gaccggccgc ctctacctgt
    20461 accccggtca cgtgggcgtg accggatacg gcaggccggt cctgatcggt tccggctgga
    20521 acggctgcac gatcctcggc gccgccgatc tgaccggcga cggcttcggc gatctggtgg
    20581 ccagggacag cggcggcgag gtctggcgtt acgacggcct gggaggcggg cggttcttgc
    20641 cccgcaagct gctcctgagc gactggggcg ccgggcgccg ggagatgttc gtggccggcg
    20701 acgtgacgcg ggacggctac ccggacctgg tctcgcggca cgcggacggc agactgctgc
    20761 tcaacaaggg caacgcggcg ggctcgttcg gggcgacggt caggatcggc accggctggg
    20821 gcgcctacac ccgcctgtac tgacgggcgc gtgcaccgac ggacgcgtgc attgacgggc
    20881 tcgtgcaccg acgggcgggc gggccgtgcg tcaccacggc ccgcgcgcgt ccgccggatc
    20941 agttcggcat cgccgcgcgc acgagcgcgg tgtccacgaa ctgctcgaag cgcacgatca
    21001 gtccgccgcg caccacgaag tggtgcgcca cccggacgtc gacgggcttg cccgtggccc
    21061 ggttcgtcgc ggtgtagcgg gcgaggacga ccacgttctc gccgtcgacc acataggtgt
    21121 cgtcgtgggc ggtccagcct tcccagtcct tgcccagctg ctccatcacg ttgctcgtga
    21181 cgccgtcggg ggtgcggtag gtgccggcga gggggaagcc ggccatctcc gtccactcca
    21241 cgtcgggggc cagggtcgcg cgcagggccg tcaggtcgcc cgccgcggac gccaggtact
    21301 ggcgccgtac gacgtcggcg ggcgccgcgg aggtgtcgaa gtcgctcatg tcagccccac
    21361 ttcatctcgc ccttggcgac cttggcgccg atctgggcgg cgatcagcat gccgttgccg
    21421 gggtagcggc cgaccagcgc ctcggtgagc gcggcgccgt cggcggtccg gccgagttcc
    21481 tcctcgaagg cgagcaggta cgcgcgggtg gcggcgatcg cggaggcgtc ggccgcggtg
    21541 ccggggagcc ggtggccggg cacgaccagg tccggctcca gcgcggccat ctcgtccagg
    21601 aggccgatcc aggcggcgcg gtcgccgggg gtgggggtgt cggcgaccca gacgtgctcc
    21661 tgctggaaga gcaggacgcc gccgagcagc gcgcggtggt cggcctgcca caggtagtgg
    21721 cggtccgcca gcgcggccgg accgcccttg agctcgaagc ggtggccctc gagcgtgagg
    21781 tcaccggtca gcggctcgat ctcgaccagc cgggtgggca ggttcgggcc gagggccgcc
    21841 caggccttga gcttgccctc gtaggagtcc cggatgtgct cgatgacgag cggtgtcgcg
    21901 acgaacctcg cctcggggaa ggcgtcggcg acgacctcgg cgccgaagta gaagtcgggg
    21961 tcggcatggc tgacgaagac ggtggtcagc ttcttgccgg agtcgaggac ctcggcggcc
    22021 aggcggtggc cgtcggcccg ggtgaaggcc gcgtcgatca gcagggcctc ctcctcgccg
    22081 gtgaccagcg tggccgtctt gttcttgctg ccggccggga agtccagatc gaggaccttg
    22141 aaggagaggg tgctcatggt gtgctccttg agggggacgg tggaacggcg gatcaggagg
    22201 cgtgggtggc gccgagcgag gcgagacggc ggtccacctc gtcgggggtg gcgtagccgc
    22261 gggccagggt gacggtgcgc gggccgtcga cggcgaggag cgtggggaag cccccgacgc
    22321 cgagtgcggc ggcgcgcgcg aagtcggcct cggcctccgc ccgggccgtc ggcccttcga
    22381 aggaggccac cacgcggtcg gcgtccaggc ccgccgcgtg agcgagctcc cggtacgtgc
    22441 ccggagcgga caggcttcgt ccatcgtgga agaacgcgcg ctgaagcgcc acagcgagct
    22501 ccgcggcgcg gtcgggcgcg ccgtgccgca gggccgccag cccgcgggcg gcggcctcgg
    22561 agtccatcac gaaggaaccc tcggcggcga gccgccggta cggctcgccg aaccgggcgc
    22621 ccgtctgcct gccgatctcg gcgttggcgc tcccgatgtg ggcgaagccg cgcatcggca
    22681 cccggcgttg cgaggtgaac agtccgccgg agatcacgtc caccggcagc tcggggtgcc
    22741 gggcgaggac ctcacgcagc gttccggaga atccgtgcga ccagccgcag taggcgtcga
    22801 aaacgtagat gagcttcatc gggaacctcg gcacaggggt gcggtccacg gggtgcggac
    22861 gcttcacctg acacaacagt agctgactcg tcagatattt ccaggcgggg ccctgatcat
    22921 ggatgtctgg ccgccctcgg cggaggtccg gttcggcggt gctcgggagg gcgcggcagt
    22981 gcgtgcccgg gtcgaccgtc cgcaggtcag gtcaggtcag ggcggggcgg gtgaggtcgg
    23041 gtcggtcggg ccgcgtcagg gcaggtcagg gcaggcgcgg gagggtgtcc cgggccgagt
    23101 ggctgaggat gcggagatcc tcggcgaacc gttcacggtc cccggcgggc agcggctcca
    23161 cgaaatagcg cttgatgttc tccacgtgca cccgggaggc ccggacggcc gtctcctcgc
    23221 ccagcgcggt gagcgtcacc agtttcccgc gccggtcctc gggggactcg gcccgcgcca
    23281 ccagcccggc ggcctccatg cggtccacca ggcgggtggc gccccccgtg gtgagcacct
    23341 gctcctgggc cacggcccgc atcggcagac ccggagcgcc cgcgcggccc aggatcagca
    23401 gcacctcgaa catcaggtgg ctgatcccgc actccacctc cagcgcccgg ccgaggatgt
    23461 actccagacg gttcgccgcc ccctgcaagc gcccgaaggc caggatcaac tcgtggtccg
    23521 cggcttcctt cgccgtcgtg atccccgctt gctcgtccac ggtccgcaac ccctctcgtc
    23581 gtacagcccc accaccgtac cgatcatgcc gtgcgccgcc ccggggcccg gcccccggct
    23641 caggcgctgt tcgccagtgc tgcccggtgg accgggtggg ccggaggccg gccggcgacg
    23701 aggcgttcga gttcgtccac cacggtggtg cccatgcggg ccagttcgtt gccgagggat
    23761 cccgcgatgt gcggggtgag gaacacgttg gggaggtcga agagaggcga gtccgcaggc
    23821 agcggctcgg ggtccgtcac gtccagcacc gcgctgagcc ggccgccggt cagttcgccg
    23881 acgagcgcgt tctggtcgac gagggcaccg cgcgaggtgt tgatgagcac gcccccgtcg
    23941 gggatgaggg ccagccgctc acggctgagc atgtggcgtg tctgcgggat gtccggggcg
    24001 tgcacgctga cgatgtcgct ggtgcgcagc agctcgtcga gcggcagcga gacggcgccc
    24061 aggtccgcgg cctgcgccgc gtccacgtag gggtcgtaca ggttcaccga gaagtcgaag
    24121 ggccgcagca gttccagcac ccgccggccc acgcgcgagg cgccgacgat gccgacccgg
    24181 cgaccgaggt tgcccacctt cgcgtactcc gccgggccgg gatgtgcgcg ctcggtccgc
    24241 aggcgctcgc gcagcccgaa ggcgtccttc ccggcgagca ggatcgcggc gagcgtgtac
    24301 tccgcgaccg ggagcgcgtt ggcctgcacc gcgctcgaaa gggtgagccc ccgctcccag
    24361 aacgggtcgc ccaccaactg ccggacgctg cccgccgcgt gcagcacggt ccgcaagcga
    24421 ggtgccgcct ccagcacctc ggccccgagg tgcgggcagc cccagcctgt gatgagcacc
    24481 tctgcccggg ccagtgcgac ggccgccgcc ggatcggaga agtcccgtac gacgaactcc
    24541 gggtcgatct ccgccagttg ccgcagccgt tccatcaccg ccggcgggaa gagtcctccc
    24601 aggtgcaccg ggtccatggc gaacagggcg acgggggagg cggagtgcga catggggctc
    24661 ctgctggtcg gccgggacgc cggcggcgcg gcggtaggcg tattccatgt cagggccgtg
    24721 cccctggtca atggcatgcc cggtcggcgg gcgccagggg cgcagggggc cgatgccggt
    24781 cggtccccgc gggatccctc ggcgtggtgc cgctcgcctg ccgcaggtgg tgagcctccg
    24841 gccttccgcg gggatcaccc gacggagcgg ccctctgcgg acacgagcgg gtccgtcccc
    24901 cgcgcccggt accggctcct gaacaccgcc cggtcgcccg cgaacaggcc ggtcatggcg
    24961 gccgccgcga gccggtcggc gaaacgcccg taggccgcgt gctcctgctc ggagaggtcc
    25021 acccggtgcg gtcgtgcgcc ggccgccgcg ggggccaggg ccgcggcgag caactcgacg
    25081 tcctcgtccg gagagagacc gaggaccgcc acggtccggt cgaccgtgcc gcggtagtca
    25141 ccgggtccgg gcacggcctc gacggccacc gagccgtcgg tgccgtgggt caccagcagt
    25201 gacggccggg ccctcgctcc ggcgcggagg gcacgtcgta cgcggacgag cgccttcacg
    25261 tcggcctcgt cgagcaggac ggggtgcagc gggaccaggc gtccgccgtc cggggcccgc
    25321 agaaggctgc ggcgggcggg gtcccgcgcg gtccgtgggg tgcgtccgcg caggacggga
    25381 gggaaggccc ggtggacgtt gcgccaggcg tcaagggcgg cgggcgcgtc cagacccttc
    25441 agatcctcca gccccgccgg gtaggggggt gcgaggtgtt cgcgcacgcc gcgccgcctg
    25501 gcggaccagg ccgcgtggta cggcgcgagc agaaggtcgt gggtctcgcg gaagtcgtgg
    25561 agccactcgg ggtcctgcgg gacgagacgg agcgtgctgg tgccgccggc tgaccgggcg
    25621 gg
//
