LOCUS       NZ_BMSI01000002        22769 bp    DNA     linear   CON 02-AUG-2024
DEFINITION  Streptomyces asoensis strain JCM 4185 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMSI01000002
VERSION     NZ_BMSI01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces asoensis
  ORGANISM  Streptomyces asoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 655051)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014649075.1-RS_2024_08_02
            Annotation Date                   :: 08/02/2024 04:45:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,813
            CDSs (total)                      :: 7,736
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 53 of 173
            Pseudo Genes (incomplete)         :: 140 of 173
            Pseudo Genes (internal stop)      :: 10 of 173
            Pseudo Genes (multiple problems)  :: 28 of 173
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 112610
            Orig. end                         :: 135379
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMSI01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22769
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22769
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22769
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12769](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12769)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    663..678
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
     gene            699..1697
                     /gene="gap"
                     /locus_tag="IE189_RS06510"
                     /old_locus_tag="GCM10010496_13190"
     CDS             699..1697
                     /GO_function="GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0006006 - glucose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gap"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715291.1"
                     /locus_tag="IE189_RS06510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13190"
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="WP_189918759.1"
                     /transl_table=11
                     /translation="MTRIAVNGFGRIGRNVLRALLERDSDLEIVAVNDLTDPAALARLL
                     AFDSTSGRLGRPVSVEGDVLVVDGRRIKVLAEREPARLPWAELEVDLVLEATGRFTSAK
                     AARAHLDAGARKVLVSAPSDGADVTLAYGVNTDAYDPELHTIVSNASCTTNALAPLAAV
                     LDDLAGIEHGFMTTVHAYTQEQNLQDGPHRDPRRARAAGVNIVPTTTGAAKAIGHVLPN
                     LDGKLSGDSIRVPVPVGSIVELNTTVARDVTREDVLAAYRAAAEGPLAGVLEYSEDPLV
                     SSDITGNPASSIFDSALTRVDGRHIKVVAWYDNEWGFSHRVIDTLELLAAG"
     gene            complement(1978..2517)
                     /locus_tag="IE189_RS06515"
                     /old_locus_tag="GCM10010496_13200"
     CDS             complement(1978..2517)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE189_RS06515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010496_13200"
                     /product="hypothetical protein"
                     /protein_id="WP_189918761.1"
                     /transl_table=11
                     /translation="MTTSTSTTYRPTAPTRATATRLPRPRPHSGLPREPTDLTAALPPA
                     FEAFCALNRSSYLDYARAHLPDVQAHRLVRRLLGELAVGWLDIISSPDPQGRAWTQLRT
                     RVQMAAPALPALETCPPHQYDALVLHCKLGYTSARAAAVMGLDASKIRYLVLSATSARR
                     QAARRLHPPPTARHAA"
     gene            complement(2514..3623)
                     /locus_tag="IE189_RS06520"
                     /old_locus_tag="GCM10010496_13210"
     CDS             complement(2514..3623)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="IE189_RS06520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13210"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_189918763.1"
                     /transl_table=11
                     /translation="MTPKDPGPAYCLNPACGKPIGRTIGSGRPRAYFSDACGRAYRKAR
                     EKSLTPDALAHQAFTGQVADELAQVITRLLQLAHTRQPLAALSLMRVAEADLEDLKAAL
                     IQQARDDRQRNADIAQCLGLPSEQLTRKYSTEAVRRRKESRPLRTRTRVRLPRQATPAP
                     SPVPQTTPATRLPAHRRTPDGGGEMTTSRARAPDRHTHGPAAVLTRALAQLHYASGKSR
                     RELATDVEVSASYVSRVLNGERCPSWKVARRLTLACGGDPAEVQPLWAAARGRIPSQRQ
                     SLPAALRGLHLAAARPHTDQIGLSTRLTEHTITGMLDGTALPSWEDVEELAHALHAEAQ
                     PLRPLWNAACAALSGPPPRTADPATKVTG"
     gene            complement(3804..3956)
                     /locus_tag="IE189_RS06525"
                     /old_locus_tag="GCM10010496_13220"
     CDS             complement(3804..3956)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE189_RS06525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010496_13220"
                     /product="hypothetical protein"
                     /protein_id="WP_189918765.1"
                     /transl_table=11
                     /translation="MQVGAFIAAPVLGIVLVLRPEAYDLAAAAVCMLLAATRRSHLRYR
                     RLRTA"
     misc_feature    complement(3958..3973)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     misc_feature    complement(4092..4105)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
     misc_feature    complement(4205..4221)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.25"
                     /tool="antismash"
     gene            4451..5077
                     /locus_tag="IE189_RS06530"
                     /old_locus_tag="GCM10010496_13230"
     CDS             4451..5077
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018534656.1"
                     /locus_tag="IE189_RS06530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13230"
                     /product="hypothetical protein"
                     /protein_id="WP_229901101.1"
                     /transl_table=11
                     /translation="MHENEKAHRSTPYALTETGHAPVWGVCAEAEETAGEMLRRGGGEV
                     IRLYVAACAERMAPLFVGLRAGEAGREADLDLYAESVRDLWYVDRPLADAAERVSLLEQ
                     FSELRPDEEGITEVGDTYAFFAVLCLRHALSAHGSGSVDDALSCGHAALTAMGMLDRNV
                     AGAGFLADEQRLQSLSLSGDASGLWDASVAVGRERFRAVLDRLPR"
     gene            5183..5809
                     /locus_tag="IE189_RS06535"
                     /old_locus_tag="GCM10010496_13240"
     CDS             5183..5809
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018553701.1"
                     /locus_tag="IE189_RS06535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13240"
                     /product="chloramphenicol phosphotransferase CPT family
                     protein"
                     /protein_id="WP_189918767.1"
                     /transl_table=11
                     /translation="MTSGRIIFLNGTSSSGKSSIARELLDILDDGVFFHLAVDAFNAMR
                     SKRELGAAELDAALRRTRMGFHRSIAAMAEAGNDVVVDHVLSEPWRLLDCLTVLRPEDV
                     LFVGVRCPREELTRRESARGDRPPGLAAHQYDLVHRHGDYDLECDTSTASPRECAEQIK
                     EFLPRRPSPTAFTRLRRRCLTDGGQPPNDGRPHSVSTAGARPDPG"
     gene            complement(5730..6644)
                     /locus_tag="IE189_RS06540"
                     /old_locus_tag="GCM10010496_13250"
     CDS             complement(5730..6644)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056172.1"
                     /locus_tag="IE189_RS06540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13250"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_189918769.1"
                     /transl_table=11
                     /translation="METMSTTPGTGLGAMIRTWRERLPPSAAGLPVARGRRATGLRREE
                     LADLAGVSVDYVVRLEQGRATTPSAPVVGSLARALQLSTAERDHLYRLARLLPPVGGTI
                     SDRLPPGMQRVLARLADVAVAVFAADWRLVWWNRGWAALLGDPAASPAPLRNFARDRFP
                     VDAGPARLALWPVTEADRDGTDAAVVSDLRRATGRFPQDGRLTTLIRELNAGNERFAEL
                     WATGGVTAHREDHKTIHHPSVGPVMVDCDVLTDGDSELKIVIMTAAPGSEDETKLQLTL
                     GPVELLPCSPSAAGRRSAVARRP"
     gene            6750..7448
                     /locus_tag="IE189_RS06545"
                     /old_locus_tag="GCM10010496_13260"
     CDS             6750..7448
                     /NRPS_PKS="Domain: PKS_KR (4-109). E-value: 2e-08. Score:
                     26.3. Matches aSDomain:
                     nrpspksdomains_IE189_RS06545_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719625.1"
                     /locus_tag="IE189_RS06545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13260"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_189918771.1"
                     /transl_table=11
                     /translation="MTITFITGANKGLGRETARRLIEHGHTVLVGARDRERGEETAAAL
                     GARHVPIDVTDDASVAAAAANVAAREGRIDVLINNAGVHGPVGDPGDLTAADAFAVLDV
                     NVLGVVRTTTAFLPLLRRSADPVVINVSSGMGSLALTHDPDRPESHVVAPLYTSSKAAL
                     TMLTTQYAKGLDGIRVNAADPGYTATDLNGHSGPQTVTEGTDAIVALATEEPGAGTGRF
                     VSRHGEIAWS"
     misc_feature    6751..6765
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.98"
                     /tool="antismash"
     aSDomain        6762..7076
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE189_RS06545_PKS_KR.1"
                     /evalue="2.00E-08"
                     /label="IE189_RS06545_PKS_KR.1"
                     /locus_tag="IE189_RS06545"
                     /protein_end="109"
                     /protein_start="4"
                     /score="26.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="FITGANKGLGRETARRLIEHGHTVLVGARDRERGEETAAALGARH
                     VPIDVTDDASVAAAAANVAAREGRIDVLINNAGVHGPVGDPGDLTAADAFAVLDVNVLG
                     V"
     CDS_motif       6765..6899
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE189_RS06545_0001"
                     /evalue="1.50E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE189_RS06545"
                     /protein_end="50"
                     /protein_start="5"
                     /score="20.9"
                     /tool="antismash"
                     /translation="ITGANKGLGRETARRLIEHGHTVLVGARDRERGEETAAALGARHV
                     "
     gene            complement(7477..8523)
                     /locus_tag="IE189_RS06550"
                     /old_locus_tag="GCM10010496_13270"
     CDS             complement(7477..8523)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:TIGR03558.1"
                     /locus_tag="IE189_RS06550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13270"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_189918773.1"
                     /transl_table=11
                     /translation="MVSLSVLDVALVAPGGTARQALHDVVRTAVAADACGYHRFWVAEH
                     HNSPRCAGSSPAVLISHIAAVTRRIRVGSGGVMLTNHAPLTVAEQFAVLQSLHDDRIDL
                     GVGRATGGTDSSTLLDRALRRPPQARAQFPQLLDELVGFLHGRWPAEHAFQDLELSPAL
                     PVPPDVFVLGTSENGARTAAARGLPFAYGAHLGPKSRPAALDRYRSAFSPGPLGASPYV
                     VASVNVQCAESDDEAERLAHDTVAARFRQKHTATSPDVSLPAPRERYLIGRMLEDLQLV
                     RGGPATVAAGLRRLAATLGADEIMLVPYDITAAGRERTLRLTAAAWTPPARPDGPGLHG
                     PQVRPAVS"
     gene            complement(8562..10001)
                     /locus_tag="IE189_RS06555"
                     /old_locus_tag="GCM10010496_13280"
     CDS             complement(8562..10001)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="IE189_RS06555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13280"
                     /product="MFS transporter"
                     /protein_id="WP_189918775.1"
                     /transl_table=11
                     /translation="MKATTAASRAAAAPVPLRANREFRLLWVGQALSDFGTSMTALVLP
                     LALLSSGYSTSATSTIGTAVLVTAMVLRMPAGYLTDHYSHRLLMLVADLARLVTVATVA
                     VWTYLDRLPIALAVITVVVAQVGVELFRPSQNATVRRVVPASQLGTAISLNQARAYAAG
                     IVAPAVAGVLIAASMWLPFAIDAVTYAVSALCVLALYRPLRRTGAAQAARPDSHADGAP
                     GQGGTQDGSQEAKAEAEAGDGATEAAAEAEAETGGGARGTVSDGGTKAAPRERFLPRLT
                     AGLRHVVRDPFLRTLAGLAAGDNFAFQALAYALLLGIGREHNGAAAVGLAMSAAAVTGL
                     TGSLIAPFVQRRLRMQTVMAAGPALAGVMLALAWYTGSGIAFAAGYSALCLLTPVNGAV
                     FGTILATTVPENIYGRTTTALGFITEILQPLGPLTAGLLLAYLSLSGTAAVFALAFAVL
                     AVVALMMPSPPAAPSPETAAA"
     gene            complement(10001..12769)
                     /gene="lanKC"
                     /locus_tag="IE189_RS06560"
                     /old_locus_tag="GCM10010496_13290"
     CDS             complement(10001..12769)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="IE189_RS06560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13290"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_189918777.1"
                     /sec_met_domain="Pkinase (E-value: 1.9e-10, bitscore: 35.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.7e-32, bitscore:
                     106.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNHPRWFEDFERRAPGGEHLREYRAVMPASWPLWRRGYWLLASP
                     PQVPAVAQGWKLHVSATSATCAATLRAVLPLLRDAGVHFKFLMDPAAMLESNGKSFPRG
                     SSGKFITVYPADEREFRAVGDALTEALAGFDGPHILSDRRYPGSRVVHYRYGGFVSISR
                     MRPSGMKELLIRTPDGEPVVDIRHPYFHLPAWVTDPFTGESAPEQPAAPQRADAAPGAT
                     TGSAGGDTGITLADGRFTVVSAMKFCNRGGIYRGIDNETGADVVVREARPGVQIGPEGT
                     DAVRLLRHEYDILTELADTGLFVRPIAFFTDWEHSFLVEEFIEGTHLGHLGIVENPVYN
                     LDLSAERLTDYYERFRTLWLQVADAIAVCHERGIVMGDLSLTNVMVTGDDRAVIIDMES
                     AFHEDAPAGPARGARLYTPGMVTRRARLAAQGDRRTDHYALGGLILGCVLLCHQTDFID
                     PTMPRRLLALAAADLELPAELTRLITDLYDEDADLPDPADLRRRIEALPLADAWRQPPP
                     LGLPPVTDAPARAELHKRVEATLEGVADFWTATADLDRQDRLFPADVTVFRTNPLSLAH
                     GAYGPLYVLHRLRGTVPDELHAWALRHSTGHDVMPAGLYFGAAGVAWAQSALGHLDIAV
                     RTLHDAHGHPQALSEPGVLTGAAGYGMACLRLWLDAGLTEFLDRAVAVGAHLTRTAHRE
                     DGLAHWPDAGRPTPIGYADGAAGIALFLLALHCATGDAASLELGRAALDFDLSQVVAGA
                     GGRLSFPATVSTDDRPVMVVRHYWDHGTAGVLTTLLRYHHVTGDPVLRERIAALLPDVR
                     RKYTVFPQLFHGTSGLGNVLLDAYEFLGDAELLAEAERVAESVLCMAIERPEGIVFPGE
                     QTVRESCDLASGSAGVALFLDRLRTARPGGRTNGNFLLDDLLPAAAGRTGA"
     gene            complement(12914..13114)
                     /locus_tag="IE189_RS06565"
                     /old_locus_tag="GCM10010496_13300"
     CDS             complement(12914..13114)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132731.1"
                     /locus_tag="IE189_RS06565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13300"
                     /product="hypothetical protein"
                     /protein_id="WP_189918779.1"
                     /transl_table=11
                     /translation="MSEEIRPDTEPVEPGDAAQADGDVEAHLAAGQDAVLGLQKLNPER
                     EASIISDPAGSGGSCHNISCF"
     misc_feature    13099..13113
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            complement(13213..13425)
                     /locus_tag="IE189_RS06570"
                     /old_locus_tag="GCM10010496_13310"
     CDS             complement(13213..13425)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132730.1"
                     /locus_tag="IE189_RS06570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13310"
                     /product="hypothetical protein"
                     /protein_id="WP_189918781.1"
                     /transl_table=11
                     /translation="MAEAEQVPVQGEDDSTKVEKAAEVARAAEVAAHSLADAVLQLQRL
                     DPEKEASIISDPAGSGGSCHNISCF"
     CDS_motif       complement(13270..13425)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAEAEQVPVQGEDDSTKVEKAAEVARAAEVAAHSLADAVLQLQRLDPEKEAS"
                     /locus_tag="IE189_RS06570_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13213..13269)
                     /prepeptide="core"
                     /locus_tag="IE189_RS06570_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-0.20"
                     /molecular_weight="1692.9"
                     /monoisotopic_mass="1691.8"
                     /core_sequence="IISDPAGSGGSCHNISCF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAEAEQVPVQGEDDSTKVEKAAEVARAAEVAAHSLADAVLQ
                     LQRLDPEKEAS"
                     /leader_location="[13269:13425](-)"
                     /alternative_weights="1710.9"
                     /alternative_weights="1728.9"
     misc_feature    complement(13627..13638)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.62"
                     /tool="antismash"
     gene            13690..14823
                     /locus_tag="IE189_RS06575"
                     /old_locus_tag="GCM10010496_13320"
     CDS             13690..14823
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946478.1"
                     /locus_tag="IE189_RS06575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13320"
                     /product="radical SAM protein"
                     /protein_id="WP_307822217.1"
                     /sec_met_domain="PF04055 (E-value: 1.3e-13, bitscore: 46.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDHGLTEKGAAMRLAELMALRQRIAAGVLVSLTERCPLSCAHCS
                     TAATRLGRDLDEAALLGFLRTFTSADRPDVLMLTGGEPLLRPGLVIEAATAARSRGTRT
                     AVLSGAFFADGGPLPSTVREVARAVDHFSLSLDAFHERYVPRRNVFDVLDALLGTGVHV
                     SLHLLADGPADPYPDEVGAQVRRRFGTDVPMLVGQVRPVGRGGTLRPRPRPPAGPDPWA
                     AAPCDMAAWPVVTTDGAVTACCNQDVADRRVRPGHLGLGDIRTTTWQTVRERARARPML
                     RMIRTVGPVHIATRAGLPADGYCATCHRLDGSDAAREWTDRAGTGPAGELLQSAAVHRG
                     EAGGPAALVARHGPARHAHLVDPGQGPAVRPRQEHTP"
     gene            14820..15560
                     /locus_tag="IE189_RS06580"
                     /old_locus_tag="GCM10010496_13330"
     CDS             14820..15560
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550945.1"
                     /locus_tag="IE189_RS06580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13330"
                     /product="iron-containing redox enzyme family protein"
                     /protein_id="WP_229901102.1"
                     /transl_table=11
                     /translation="MTTPSGPLAAAPGVCHTRAPLGAELRTVLALVAPVLHHSAARLWQ
                     PQDLRARYLRYLVTMHTVIRASVPLMERARAACRDAPATDPAAGPLYRYLTAHIPRERH
                     HDTWLLRDMEAAGLHPGHELARPPSPEVARLVGAQYYWIDHFHPLSLLGYVAVLELNAP
                     APSLIPLLAARTGLPPAAFDTLRLHAEIDDGHSTAVLGALDESAPAPQVRAAVRLSALH
                     TVTALADVLNSLADLTDRTGGPAE"
     gene            15574..15819
                     /locus_tag="IE189_RS06585"
                     /old_locus_tag="GCM10010496_13340"
     CDS             15574..15819
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577231.1"
                     /locus_tag="IE189_RS06585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13340"
                     /product="aroma-sacti cluster domain-containing protein"
                     /protein_id="WP_229901103.1"
                     /transl_table=11
                     /translation="MTADSGGESAVDGAGEHDTGSVLRALEQAGFPVRAFTGEQRAVFA
                     GLTPQELALILDLKTRLDAVEPEVQAHTVVAGAALF"
     gene            15927..19046
                     /locus_tag="IE189_RS06590"
                     /old_locus_tag="GCM10010496_13350"
     CDS             15927..19046
                     /GO_process="GO:0009190 - cyclic nucleotide biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0035556 - intracellular signal transduction
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="IE189_RS06590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13350"
                     /product="adenylate/guanylate cyclase domain-containing
                     protein"
                     /protein_id="WP_189918783.1"
                     /transl_table=11
                     /translation="MQQRKVITALFCDLVGSTELSGTLEPETLRSVVLRYFDAMRGGIE
                     SHGGTVEKFIGDAVMAVFGVPHVHEDDAHRAASAALEMIAALDGLNTELDRDFGSTLAV
                     RIGLNSGEAVTSQDLENDGTVVSGEVVNVAARLEQAAQPGHILIGPATRTLLGPAAVVE
                     AVGPLTLKGKRDPVDAFRLLRLTAQDGPPGAARPAADLVARTREYDRLATAWRRASRDG
                     TGRLIRLTGDAGIGKTRLLREWLAARSAEGSLVGTGRCHSYRDEASLAPLAAAIREVLD
                     TATAGTAPAAVRSGAPQGPAPARPWDGAAYEVLRGGLLADGTPSPSAEATWAAAAAVLR
                     GLTAVGPVALVLDELQWARPQLLEGIVRLTEVLAKSPVLLICSQRPGEDERPTTADEIR
                     LRPLSRADSLRLARALAGAGPDDGVLHTVVERAEGNPLHLEQLLTMVEDGADPGGLPVT
                     VTAVLAARIDVLPQPQRTVLDAGAVIGRRFTVEEVRRLLDDPPAETALPEHTPVTGAVH
                     ELVRRGLVEPAPGAPATYRFSSGLLRDVTYRCLSKSRRAAWHERLATRPGTAPALASHH
                     LEAAYVLRRDLGLRGEHVEGLRGRAADALSRAGRHALARADLSWSAELHARSLAHCAPG
                     EARWRHAAQGLGETWLALGRTGEGGDLLTQVRDAAATAEDRLSGAHAGLQLASLYPDAS
                     PTAAADAARAALAVFGEFDDRLGLARAHVRLAQEQQYAGRHRAASDLLAVALGHALAAD
                     AAPERAMALGALGISLWHGPTPAGEAIERCRALLAEHGPGNPVVVVALNYPLANLLALC
                     GRTGEARGCLTDAERFAVGLGYAEVAAFGPLFAAGVEVLAGSTAQAERLLRQAVETFRT
                     VGGPQLHAAACRDLARVLLARGLPWPAAPDDIRDVTPGPEPAGAGRPGEAVPAPAMALP
                     PADAADDFGVRALAAAAAGNAPDALRLARRAVAAADTTDSPIGRATARLDMAQVLYTTG
                     RPQAAVRSADRAALLFRAKGHAVGATAAAHLAARAAESIPDRTEASGDGR"
     gene            19112..>19849
                     /locus_tag="IE189_RS06595"
                     /old_locus_tag="GCM10010496_13360"
                     /pseudo=""
     CDS             19112..>19849
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010062911.1"
                     /locus_tag="IE189_RS06595"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13360"
                     /product="S8 family serine peptidase"
                     /pseudo=""
                     /sec_met_domain="Peptidase_S8 (E-value: 1.4e-24, bitscore:
                     82.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGPVTPDWAWGGSTGRGVRVCIVDSGVERDHLMVGRVASAHVVV
                     EGDDGRPRTVPSDSGDACGHGTACAGIVREVAPDCELHSVRVLGERFTGTGDFLLAGLR
                     WAVEQGFDVINMSLSTTHERFLRELHELADEAYFRRCVVVASAHNSPVVSFPWRFSSVV
                     SVGSHQEDDTGLHLYNPDPPVEFYAKGQDVRVAWLDNCVTRTTGNSFATPRVAGLCALI
                     LAKHPALTVFQLKTVLYLTAANVR"
     gene            20074..20622
                     /locus_tag="IE189_RS06600"
                     /old_locus_tag="GCM10010496_13370"
     CDS             20074..20622
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132724.1"
                     /locus_tag="IE189_RS06600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13370"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_189918785.1"
                     /transl_table=11
                     /translation="MSPILPSDDTHALLQSVVDVARAIFAAAASSVFLLDDTAGELVFQ
                     AVSGEGEDMLVGTRFPAHRGIAGWVASSGQAMIADDLASTRTFARDLAESTGYVPNALM
                     AAPLLSQQRVLGVLEVLDPSPRPRAGLEDLDLLSLFAAQAAIALRVTGRSSGTGTTAPG
                     ATDEQLTDAFRAFLRDRSH"
     gene            complement(20735..22420)
                     /locus_tag="IE189_RS06605"
                     /old_locus_tag="GCM10010496_13380"
     CDS             complement(20735..22420)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="IE189_RS06605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010496_13380"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_189918787.1"
                     /transl_table=11
                     /translation="MRVDGGGTADLGGPKPRLLLAVLVSQANNVLSVDGLIDALWDGRP
                     PRTARKNLQVYVSRLRRVLGGRLTHTPGGYLLRLEPSECDLLRFEELARIGRRRTRDGD
                     TDSACDALVRALELWQDRPLREFGDVPYLTAAVDRLQEMQVSVLEDWAELENGRGRHAL
                     VLDRLQEHVVRHLLRERLAAAWITALAATGRQSEAAAHFDSVRRALTRELGVTPGPALA
                     ALHRRLLGAPAPERRPGPGNQLPRDLPDFVGRADEVQRALGYFRARRESGVMVVSGPVG
                     VGKSALAVRVAHLLADAFPDGLIMTELGNRPLGSVLRALLDSVGLPGTQNVAQALARWR
                     TWVAGRRILLVLDDAVGQQTVLALLPGSGASCTLVTSRYRLSGLEAVARVELPPFQGGE
                     SIELLGRIVGFGRVMSDQASARRIVQCCEGLPLAIRIIAAKLESLRHVRLADYADRLSV
                     APSLLDEMAVGELVLRERYEAFWRDLPQQQRLAYRRLSSLTPPFRYDQVIAEVEELHEC
                     NLLMPPAGEVSAHFAAYGMSGFTHEFGRRVTGLTAVDLPPVAGT"
     misc_feature    complement(22328..22330)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(22364..22366)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 tcttcgtcga cgagggcagc gtgctgacgt cggccggcgc cgcctccggc atcgacctgt
       61 gcctgcacat cctgcgccgc gacctcggcg tggccgcgtc gaaccacgcg gcccggcgcc
      121 tggtcgccgc cccctaccgc agcggcggcc aggcgcagta cgtgccgcgc agcgtgcccg
      181 agccgctggg ggagaggttc gccgccaccc gcgaatgggc gctgcaccgg ctggacgagc
      241 ccctgaccct ggaggcgctg gcccggcacg cggcggtctc ggaccgtacc ttctcgcggc
      301 ggttcgtcga ggacaccggg tacacaccga tgcagtgggt catgcgcgcg cggatcgacc
      361 tggcccgcga actgctcgaa cgctccgagc gcagcgtcga gcagatcgcg aacgacgtcg
      421 gactcggcac gggcgcgaat ctgcgcaccc acttccagca gatcctcggc accaccccga
      481 gcgagtaccg ccgcaccttc acgaagggcg agtgaccggg ggaggggaga gggcgagcag
      541 ggcgcgtgcg gcgactacgc cgggtacggc gggtacggcg actacggcgg gttcgcgggg
      601 tatggcgaga tcctttcgaa ccatggcgct cgcgcctacg gcgcggccgc ccgccgcacg
      661 cgaggctggt ggcgaaccgc agggaaggga ccccactcat gactcgcatc gccgtcaacg
      721 gattcggccg catcggacgc aacgtgctgc gcgcgctcct ggagcgcgac agcgacctcg
      781 agatcgtcgc cgtcaacgac ctcacggacc ccgccgccct cgcccggctg ctcgccttcg
      841 actccacgtc cggccggctg ggccgcccgg tcagcgtcga aggcgacgtc ctcgtggtcg
      901 acggccggcg gatcaaggtg ctcgccgagc gcgagccggc ccgcctgccc tgggccgagc
      961 tcgaggtcga cctggtgctg gaggcgaccg gccggttcac ctcggccaag gccgcccgcg
     1021 cccacctcga cgcgggcgcc cgcaaggtgc tggtcagcgc gccctccgac ggcgccgacg
     1081 tcacgctcgc ctacggcgtc aacaccgacg cgtacgaccc cgaactgcac acgatcgtct
     1141 ccaacgcctc ctgcacgacc aacgcgctcg ccccgctggc ggccgtcctg gacgacctgg
     1201 ccgggatcga gcacggcttc atgacgacgg tgcacgccta cacgcaggag cagaacctcc
     1261 aggacggccc gcaccgcgac ccgcgccgcg cccgtgccgc gggcgtcaac atcgtgccga
     1321 ccacgacggg cgccgcgaag gcgatcggtc acgtgctgcc gaacctcgac ggcaagctgt
     1381 ccggcgactc gatccgggtg ccggtgccgg tgggctcgat cgtcgagctc aacaccaccg
     1441 tcgcccgcga cgtgacgcgc gaggacgtgc tggcggccta ccgcgccgcg gccgaggggc
     1501 cgctcgccgg tgtcctcgag tactcggagg acccgctggt ctcgtccgac atcacgggca
     1561 acccggcgtc gtccatcttc gactccgccc tcacccgggt cgacggccgg cacatcaagg
     1621 tggtggcctg gtacgacaac gagtggggct tctcccaccg cgtgatcgac accctggaac
     1681 tgctcgccgc gggctgacca cccgccgcac cgcgcccacc ctccgtccac ctggccctcc
     1741 gtccaccgga ccctccgtcc acgggacgct ctgtccaccg ggcgatcgac gcccgggcgg
     1801 gcaggggtcg ggggcggggg gccgcctcgc gaaccggcgc gcccgtacgg cgtgcaatcg
     1861 gcgtctgcct ttgggggatc cacgacaagg agagccgtcc cgtgcgggcg gcgcccgtcg
     1921 gtcgcggcct cctcaggccc cttgccgccg ggccggctcc ggttcgcggc gcggtcgtca
     1981 ggcggcgtgg cgggctgtgg gcggagggtg caggcgccgt gcggcctggc ggcgggccga
     2041 cgtcgccgac aggaccaggt agcggatctt gctggcgtcc aggcccatga cggcggcggc
     2101 acgggcgctg gtgtagccga gcttgcagtg caggacgagc gcgtcgtact ggtgcggggg
     2161 gcaggtctcg agcgcgggca gggcgggggc ggccatctgc acccgggtgc gcagttgtgt
     2221 ccaggccctg ccctgggggt cggggctgct gatgatgtcg agccagccga cggcgagttc
     2281 gccgagcagg cggcgtacca ggcgatgggc ctggacgtcg ggcaggtggg cacgggcgta
     2341 gtcgaggtag ctgctgcggt tgagggcgca gaacgcctcg aaggcggggg gcagtgccgc
     2401 ggtgaggtcg gtcggctccc ggggcagtcc gctgtgcggg cgggggcgcg ggagtcgcgt
     2461 cgccgtggcg cgggtgggtg cggtgggacg gtatgtggtg gaggtggagg tggtcatccg
     2521 gtcaccttgg ttgcggggtc ggcggtgcgg ggcggcgggc cgctgagggc ggcgcaggcg
     2581 gcgttccaca ggggccgcag cggctgggct tcggcgtgga gtgcgtgggc gagttcctcg
     2641 acgtcctccc aggaggggag ggccgtgccg tcgagcattc cggtgatggt gtgctcggtc
     2701 aggcgggtgc tcaggccgat ctggtcggtg tggggccggg cggcggccag gtgcagtccg
     2761 cgcagggcgg cgggaaggct ctggcgttgg ctcgggatcc ggccgcgggc ggccgcccac
     2821 aagggctgga cctctgccgg gtctccgccg caggcgaggg tgagccggcg ggcgaccttc
     2881 caggacgggc agcgttcgcc gttcaggaca cgcgacacgt aggaggcgga cacctcgacg
     2941 tcggtggcga gttcgcgacg ggacttgccg ctcgcgtagt gcagttgggc cagggcccgt
     3001 gtgagtacgg cggccgggcc gtgggtgtgc cggtcgggag ctctggcacg ggatgtcgtc
     3061 atctctccac cgccgtcggg tgtgcggcgg tgggccggca gccgcgtcgc cggagtcgtc
     3121 tgcggcacgg gggagggcgc gggcgtggcc tggcgtggca ggcggacccg ggtcctggtg
     3181 cgcagggggc ggctctcctt ccggcggcgc acggcttcgg tggagtactt gcgggtgagc
     3241 tgttccgagg gcagccccag gcactgggcg atgtcggcgt tcctctgccg gtcgtcgcgg
     3301 gcctgctgga tcagtgcggc tttgaggtcc tcgaggtcgg cctcggccac ccgcatcagg
     3361 ctcagcgccg ccaggggctg gcgtgtgtgg gccaactgca acaggcgcgt gatgacttgg
     3421 gccagctcgt cggcgacctg gccggtgaag gcctggtggg cgagggcgtc cggggtgagg
     3481 gacttctcgc gggccttgcg gtaggcgcgg ccgcaggcgt cgctgaaata cgcgcggggc
     3541 cggccggacc cgatggtgcg gccgatgggc ttgccgcacg ccgggttgag gcagtaggcg
     3601 gggcctgggt ctttcggtgt catgacaggg ggcatccctt ccgcgaagtg ccgccggaaa
     3661 caggccggtg cgtaaatgga gagattcggc agatcccgac acggcgtggc gccggccgtg
     3721 cgggtccggg tggatgaatc ctccgtgcac ccggtgcctg ccgcccggca gcctgctgct
     3781 gccgggcgac ggacacctgc ttgtcaggcg gtgcgtagcc gccggtagcg caggtgcgag
     3841 cgacgtgtcg cggccagcag catgcagacc gccgctgcgg cgaggtcgta cgcctcgggc
     3901 cgcaggacca gcacgatgcc gaggacgggg gccgcgatga acgcccctac ctgcatggtg
     3961 acttccctgt cacgcagatc gcgagtttca accgcggctt gctgcgggat gttacggtcg
     4021 aaccgcttcg gccgagccgg atccagtgac cggccgaaga gagaagtggg gtcagggggc
     4081 atatcaactc cttgatctag aagaagagtt gagtcgagcc ccggtttggt atcccgccgt
     4141 cgccggggct cactcgcgcg ttgaggggaa cgtacatgct cactcaaaca aacgcatagc
     4201 actaccgtac gtaaatgaca tcgctgcggt atccgacacc ggtgcacgtg caagacggtc
     4261 agcttcgaac gccatgcggt cggaaacggt ccccatagcc cgccgggtgg ctcaacttcc
     4321 tcgcccggag cagccatctt cgtaaggcac acccccctcg gccacctcgc acgcaaccac
     4381 cgtcccgacg catccgcact gaccgccgcc gccccgagca cccccgcgtg gctggggcat
     4441 gatctctgct gtgcatgaga acgagaaggc gcaccgcagc acgccgtacg cgctcaccga
     4501 gacggggcac gcccctgtgt ggggcgtctg cgccgaagcg gaggagactg ccggggagat
     4561 gcttcgtcgg ggaggtggcg aggtgatccg tctgtatgtg gccgcttgtg ccgagcggat
     4621 ggcgcccctg ttcgtgggcc tgcgggcggg cgaggcgggg cgcgaggccg acctggacct
     4681 ctacgcggag tccgtgcgcg atctctggta tgtcgaccgg cccttggccg acgcagccga
     4741 gcgcgtgagc ctgctggagc agttttctga gctccggccg gacgaggagg ggatcaccga
     4801 ggtcggcgac acctacgcct tcttcgctgt cctgtgccta cggcatgcct tgtcggccca
     4861 tgggtcggga agcgtcgacg acgcgctgtc ctgcggccat gcggcgctca ccgcgatggg
     4921 gatgcttgac cggaacgtgg caggtgccgg ctttctcgcc gacgaacagc ggctccagtc
     4981 gttgtctctg agcggcgacg cctccggtct gtgggacgcg agcgtcgccg tggggcggga
     5041 aaggttccgc gctgtgctgg accggctgcc gcgttagaca tgcttcctga tcgttgccgg
     5101 tgagttgtgc cgcaccccgc ccgctgccgt gcgagcacat cgcagccgaa caggcgccac
     5161 gacggcatgt gaccatgctg atatgacatc tggccggatc atcttcctca acggcacctc
     5221 cagctcgggg aagtcgagca tcgcgcgcga gctgctggac atcctggacg acggtgtctt
     5281 cttccacctg gcagtcgacg ccttcaacgc gatgcgcagc aagcgggagc tgggggccgc
     5341 ggagctcgac gccgcgctgc ggcgcacccg gatgggcttc caccgctcga tcgcggcgat
     5401 ggccgaggcg ggcaacgacg tcgtggtcga ccatgtgctg agcgagccgt ggcggctgct
     5461 cgactgtctg acggtgctgc ggcccgagga tgtcctgttc gtaggcgtcc gctgtccgcg
     5521 cgaggaactg acccgccgag agtcggctcg gggcgaccgt ccgccaggcc tcgcggcgca
     5581 ccagtacgac ctggttcacc gccatggcga ctacgacctg gagtgcgaca ccagcacggc
     5641 gagtccacgc gaatgcgctg agcagatcaa ggagttcctc ccgcgccgcc ccagccccac
     5701 cgccttcacc cgcctccgtc ggcgctgtct cacggacggc gggcaaccgc cgaacgacgg
     5761 ccggccgcac tcggtgagca cggcaggagc tcgaccggac ccagggtgag ctggagtttg
     5821 gtctcgtcct cgctgccggg tgcggcggtc atgatgacga tcttgagctc ggagtcgccg
     5881 tcggtcagga cgtcgcagtc gaccatgacc gggcccaccg acgggtggtg aatcgtcttg
     5941 tggtcctcgc ggtgtgcggt gacccctccc gtcgcccaca gctcggcgaa cctctcgttg
     6001 cccgcgttca gttcacggat cagcgtggtc aagcggccgt cctgagggaa acggccggtg
     6061 gcgcggcgca ggtcggagac gacggcggcg tcggtgccgt cgcggtccgc ctcggtcacc
     6121 ggccacagcg cgaggcgggc ggggccggcg tccaccggga acctgtcgcg ggcgaagttg
     6181 cgcagcggtg ccggcgaggc ggccgggtcg cccagcaggg ccgcccaccc gcggttccac
     6241 cacaccagtc gccagtccgc cgcgaacacg gcgaccgcca cgtccgcgag gcgggcgagc
     6301 acccgctgca tgccgggcgg aagacggtcg gagatcgtcc cgcccaccgg cggcaggagc
     6361 cgggccagcc ggtacaggtg gtcccgctcg gcggtggaca gctggagggc acgcgcaagg
     6421 gaccccacca caggcgccga cggtgtcgtg gcccgcccct gctccagacg cacgacgtag
     6481 tcgaccgaca ccccggcgag gtccgccagc tcttcgcgcc gcagtccggt ggcccggcgc
     6541 ccgcgggcga ccggcagccc ggcggccgac gggggcagcc gctcccgcca cgtgcggatc
     6601 atcgcgccca gaccggttcc aggggtcgtc gacatggtct ccatcctccc gcatccccgg
     6661 tcgtgcgccg gctcgcgaag gtggtaccgg tcgtcctacc gtcggggcgt ccctggcccg
     6721 cctcccgcgg cgaggcgagg atcgaacgca tgacgatcac cttcatcacc ggagccaaca
     6781 aggggctcgg ccgtgagacc gcccgccgcc tgatcgagca cggccacacc gtgctggtcg
     6841 gcgcccgcga ccgtgagcgg ggcgaggaga ccgccgccgc cctcggcgca cgccacgtcc
     6901 ccatcgacgt gaccgacgac gcctccgtgg ccgccgcggc cgcgaacgtc gccgcacgcg
     6961 agggcaggat cgacgtcctg atcaacaacg ccggtgtgca cggtcccgtc ggcgaccccg
     7021 gtgacctcac cgccgccgac gccttcgccg tcctcgacgt caatgtcctc ggtgtcgtcc
     7081 gcaccaccac cgcgttcctg ccgctgctgc gccgctcggc ggaccctgtc gtcatcaacg
     7141 tcagcagcgg catgggctcc ctcgccctca cccacgaccc cgaccggccc gagtcgcacg
     7201 tcgtagcgcc gctgtacacc tcctcgaagg cggcgctgac gatgctgacc acgcagtacg
     7261 ccaagggact cgacggcatc cgcgtcaacg ccgccgaccc cggctacacc gccaccgacc
     7321 tcaacggtca cagcggcccc cagaccgtca ccgagggaac ggacgcgatc gtcgccctcg
     7381 ccaccgagga gcccggtgcc ggcaccgggc gtttcgtctc ccgccacgga gagatcgcct
     7441 ggtcctgaaa ccggccgtgc cggaccggtc ctcgtctcag gagaccgcgg gacggacctg
     7501 tgggccgtgg agcccgggcc cgtcgggccg tgcgggaggt gtccaggcgg cggctgtcag
     7561 gcgcagggtg cgttcgcggc cggcggcggt gatgtcgtac gggacgagca tgatctcgtc
     7621 ggcgcccagc gtggcggcca gccgccgcag gcccgcggcg acggtggccg ggccgccgcg
     7681 cacgagctgg aggtcctcca gcatcctgcc gatcaggtac cgctcccgtg gtgcgggcag
     7741 ggagacgtcc ggggacgtcg ccgtgtgctt ctggcggaac cgtgcggcga cggtgtcgtg
     7801 ggcgaggcgc tcggcctcgt cgtcggactc cgcgcactgc acgttgacgg acgcgacgac
     7861 gtacggactc gcgcccagcg ggccggggga gaaggccgac cggtagcggt ccagggccgc
     7921 ggggcgcgac ttgggtccga gatgggcgcc gtaggcgaag ggcagcccgc gcgcggcggc
     7981 ggtgcgggcg ccgttctccg aggtaccgag gacgaacacg tccggtggca ccggcagtgc
     8041 cggggagagc tccaggtcct ggaaggcgtg ctcggccggc cagcggccgt ggaggaagcc
     8101 gacgagttcg tcgaggagct gcgggaactg cgcgcgagcc tgcggcggac ggcgcagggc
     8161 ccggtcgagg agggtgctgc tgtccgtgcc gccggtcgcg cggccgacgc ccaggtcgat
     8221 ccggtcgtcg tgcagcgact gaagcacggc gaactgctcc gcgacggtga gcggcgcgtg
     8281 gttggtcagc atcaccccgc cggaaccgac ccggatgcgg cgggtcaccg ccgcgatgtg
     8341 cgagatcagc acggccggtg aactgcccgc acatcgaggg gagttgtgat gctctgccac
     8401 ccagaagcgg tggtagccgc aggcgtcggc ggccaccgcc gtgcgcacga cgtcgtgcaa
     8461 ggcctgccgg gcggtgccgc cgggcgcgac cagcgccacg tccagcacgg acagcgaaac
     8521 catggaacct ccctggaggg gtcgggcggc gctcgtggtg gtcaggccgc ggccgtttcc
     8581 gggctcggcg cggccggtgg cgacggcatc atcagggcga cgaccgcgag cacggcgaag
     8641 gccagggcga acacggcggc ggtgcccgac agcgacaggt acgccagcag caggcccgcc
     8701 gtcagagggc cgagcggctg gaggatctcc gtgatgaacc ccagggccgt cgtggtgcgg
     8761 ccgtagatgt tctccggcac cgtcgtggcc agaatggtcc cgaacacggc gccgttgacc
     8821 ggagtgagca ggcacagcgc ggagtatccg gcggcgaacg cgatgccgct cccggtgtac
     8881 caggcgaggg cgagcatgac gccggcgagc gcgggaccgg ccgccatgac ggtctgcatg
     8941 cgcagtctgc gctgcacgaa gggggcgatc agcgacccgg tcagtccggt caccgccgcc
     9001 gcgctcatcg cgagacccac cgccgcggcg ccgttgtgct cccgcccgat gcccagcagc
     9061 agggcgtagg cgagggcctg gaacgcgaag ttgtcgcccg cggccagccc ggcgagcgtg
     9121 cgcaggaagg ggtcgcggac gacatggcgc agccccgcgg tcagcctggg caggaagcgc
     9181 tcgcgcggcg cggccttcgt cccgccgtcc gacaccgtcc cccgcgcacc tccgcctgtt
     9241 tccgcctctg cctctgccgc tgcctcggtc gctccgtcgc ctgcctccgc ctccgccttc
     9301 gcctcctgcg acccgtcctg cgtcccgccc tgccccggtg ccccgtccgc gtggctgtcg
     9361 ggccgggcgg cctgagcggc cccggtccgg cgcaggggcc ggtacagggc cagtacgcac
     9421 agcgcggaca ccgcgtaggt gacggcgtcg atggcgaacg gcagccacat cgaagccgcg
     9481 atgagcacac cggccacggc cggggcgacg atcccggcgg cgtaggcccg cgcctggtta
     9541 agggagatgg cggtgcccag ctgcgaggcg ggcacgaccc ggcggacggt ggcgttctga
     9601 ctcggccgga acagctccac ccccacctgc gccacgacca ccgtgatcac ggcgagcgcg
     9661 atcggcagcc ggtccaggta cgtccacacg gcgacggtgg cgaccgtgac caggcgggcc
     9721 aggtcggcga cgagcatcag gagccggtga ctgtagtgat cggtgaggta cccggccggc
     9781 atccgcagca ccatcgccgt caccagcacg gcggtgccga tggtgctggt ggccgacgtc
     9841 gagtacccgc tgctcagcag ggcgagcggc agcaccagcg cggtcatgga cgtaccgaag
     9901 tcggacagcg cctgccccac ccacaggagc cggaactcgc ggttggcccg cagcggtacc
     9961 ggggcggcgg ccgctcgtga ggcggccgtg gtcgccttca tcacgcaccg gtccggcccg
    10021 cggcggcggg cagcaggtcg tccagcagga agttgccgtt ggtgcggccg ccggggcggg
    10081 ccgtgcgcag gcggtccagg aacagcgcca ccccggccga cccgctcgcg aggtcgcagc
    10141 tctcccgcac ggtctgttca ccggggaaga cgatgccctc cggtcgctct atcgccatgc
    10201 acagaacgga ctcggccacc cgctccgcct ccgccagcaa ctcggcgtcg ccgaggaact
    10261 cgtaggcgtc gagcaggacg ttgcccagtc cgctcgtccc gtggaacagc tgcgggaaca
    10321 ccgtgtactt gcggcggacg tcgggcagca gcgcggcgat ccgctcgcgc agcacgggat
    10381 cgccggtgac gtggtggtag cgcagcaggg tggtgaggac accggccgtg ccgtggtccc
    10441 agtagtgccg tacgaccatg acgggtctgt cgtccgtgga caccgtcgcg gggaacgaca
    10501 gccggcctcc ggctccggcg accacctggg acaggtcgaa gtcgagtgcg gcccggccca
    10561 gttccagcga cgccgcatcc ccggtggcgc agtgcagggc gagcaggaac agggcgatgc
    10621 cggcggcgcc gtccgcgtag ccgatcgggg tcggccggcc cgcgtcgggc cagtgggcca
    10681 ggccgtcctc gcggtgcgcc gtgcgggtca ggtgagcgcc gacggcgacg gcgcggtcga
    10741 ggaactccgt gagccccgca tcgagccaca gccgcaggca cgccatgccg tagccggccg
    10801 cgccggtcag tacaccgggc tcggacaggg cctgcgggtg gccgtgcgcg tcgtggagtg
    10861 tccgtacggc gatgtccagg tggccgaggg ccgactgcgc ccaggccacg cccgccgcgc
    10921 cgaagtacag gccggccggc atcacgtcgt gcccggtgga gtgccgcaga gcccaggcgt
    10981 gcagctcgtc gggcaccgtg ccccgcagcc ggtgcagcac gtacagcggg ccgtacgccc
    11041 cgtgggcgag cgagagcgga ttggtccgga acaccgtgac gtcggcgggg aacaaccggt
    11101 cctgacggtc gaggtcggcg gttgcggtcc agaagtcggc gacaccctcg agcgtggcct
    11161 ccacccgctt gtgcagctcg gcgcgcgccg gcgcgtccgt caccgggggc agacccagcg
    11221 ggggcggctg tcgccaggcg tccgcgaggg gcagcgcctc gatccgccgg cgcaggtcgg
    11281 cggggtcggg caggtcggcg tcctcgtcgt acaggtcggt gatcaaccgg gtgagttccg
    11341 ccgggagttc gaggtcggcg gccgccaggg ccagcagtct gcgcggcatc gtcgggtcga
    11401 tgaagtcggt ctggtggcag agcaggacgc agcccaggat cagaccgccg agggcgtagt
    11461 gatcggtgcg ccggtcgccc tgcgcggcga gcctcgcgcg acgggtcacc atgccggggg
    11521 tgtagagccg ggccccgcgc gccgggcctg cgggggcgtc ctcgtggaag gcggactcca
    11581 tgtcgatgat cacggcccgg tcgtccccgg tgaccatgac gttggtcagc gacagatcgc
    11641 ccatcacgat gccgcgttcg tggcacacgg cgatggcgtc ggccacctgg agccacaggg
    11701 tgcggaaccg ctcgtagtag tcggtcaggc gctcggcgct cagatcgagg ttgtagacgg
    11761 ggttctcgac gatgccgagg tgcccgagat gggtgccctc gatgaactcc tcgacgagga
    11821 acgaatgttc ccagtcggtg aagaacgcga tcgggcggac gaacaggccc gtgtcggcga
    11881 gttccgtgag gatgtcgtac tcgtgccgca gcagccggac ggcgtccgtt ccctccggtc
    11941 cgatctgcac gccgggccgg gcctcacgga cgaccacgtc cgcgcccgtc tcgttgtcga
    12001 tgccgcggta gatgccgccg cggttgcaga acttcatcgc gctcacgacg gtgaagcgcc
    12061 cgtcggcgag ggtgatgccg gtgtcaccgc ccgcggaccc ggtcgtcgcc ccgggcgcgg
    12121 cgtcggcccg ttgcggggcc gcgggctgct ccggggcgga ttccccggtg aagggatccg
    12181 tcacccaggc cgggagatgg aagtacgggt gccggatgtc cacgaccggc tcgccgtccg
    12241 gggtgcggat cagcagttcc ttcatcccgg agggccgcat ccgggagatc gacacgaaac
    12301 caccgtagcg gtagtggacc acccgcgatc cgggatagcg ccggtcggag aggatgtgcg
    12361 ggccgtcgaa gccggccagg gcctcggtca gcgcgtcgcc gaccgcccgg aactcccgct
    12421 cgtcggccgg atacacggtg atgaacttcc cgctcgaacc cctggggaag gacttgccgt
    12481 tggactccag catcgccgcc gggtccatca ggaacttgaa gtgcacgccg gcgtcacgca
    12541 gcagcggcag cacggcgcgc agggtggcgg cgcaggtcgc ggaggtggcc gacacatgca
    12601 gcttccaccc ctgggcgacg gccggcacct gcggcggcga ggccagcagc cagtagcccc
    12661 ggcgccacag cggccaggag gcgggcatca ccgcccggta ctcgcgcaag tgctctccgc
    12721 cgggcgcgcg gcgctcgaag tcctcgaacc agcgcgggtg gtttgtcata taggtctgga
    12781 tgatttccca ctcgagctgc attccgccca tcccctctgc cgagaccgga agttgatgac
    12841 gcgccgtccg gacgggccgg ggaaccgctg tccccggccc ggcggaacgc cgcgatcgcg
    12901 cgaacgccag ctgtcagaaa cagctgatgt tgtggcagga gcccccgctt ccggcggggt
    12961 cgctgatgat ggaggcctcc ctctcggggt tgagcttctg cagacccaga acggcgtcct
    13021 ggccggccgc caggtgtgcc tccacgtcgc cgtcggcctg tgcggcgtcc ccgggctcga
    13081 cgggctcggt gtcgggacgg atctcctcgg acatggcgtc actcctcaca tcgactggta
    13141 cggggtgtac ggcgttgccg cggttctccg gccgcagggc tccctggacg cccggcgccg
    13201 gtcatcggcc ctctagaagc agctgatgtt gtggcaggag cccccgcttc ccgcggggtc
    13261 gctgatgatg gaggcctcct tctccgggtc gagccgctga agttgcagga cggcgtcggc
    13321 gagcgagtgg gcggccacct cggccgcgcg ggccacctcg gcggccttct cgaccttggt
    13381 ggagtcgtcc tcgccctgca cgggtacctg ctccgcttcc gccatgggat ctccctccct
    13441 cgtgagcatg aggccggtcc ggcccatccc ggtccggctg gccccagacg gtaggaaccc
    13501 ccgccacaag agcggttgac ggacggtgaa cacgcagctc cggccccctg tggagggatg
    13561 ccgaggagcc cctccgggtg tgcgccgacc gccgccgttc cgcaccacgc aggcctgacc
    13621 tgcacatata ccgttttcga accgcttcgc agccacgggt tcgacactcg ggccggtgaa
    13681 ggacgacctg tgccggacca cggcctcacc gagaaggggg cggccatgcg gctggccgag
    13741 ctgatggcgc tgcgccagag gatcgcggcg ggcgtcctgg tctcgctcac cgagcgctgc
    13801 ccgctgagct gcgcccactg ctccacggcc gccacccgcc tcggccgcga cctcgacgag
    13861 gcggcgctgc tcggcttcct gcggaccttc acgtccgcgg accgcccgga cgtgctgatg
    13921 ctgaccggcg gcgagcccct gctgcggccc ggcctggtga tcgaagcggc caccgccgcc
    13981 cgctcgcgcg gcacccgcac ggcggtgctc tccggcgcgt tcttcgccga cggcggcccg
    14041 ctgccgtcca ccgtgcggga agtcgcccgc gccgtcgacc acttctcgct cagcctcgac
    14101 gcgttccacg agcgctacgt cccgcgccgg aacgtgttcg acgtgctcga cgcactgctc
    14161 ggcaccggcg tccacgtcag cctgcacctc ctcgcggacg gcccggcgga cccctacccc
    14221 gacgaggtcg gcgcgcaggt ccggcgccgc ttcggaaccg acgtaccgat gctcgtcggg
    14281 caggtgcgcc cggtgggccg cggcggcacg ctgcgcccgc gcccccgccc gccggccggc
    14341 cccgacccgt gggcggccgc cccctgcgac atggccgcct ggccggtcgt caccaccgac
    14401 ggcgccgtca ctgcctgctg caaccaggac gtcgccgacc gccgggtgcg ccccggccac
    14461 ctcggcctcg gcgacatccg tacgacgacc tggcagaccg tgcgcgagcg ggcgcgggcc
    14521 cgcccgatgc tgcggatgat ccgcacggtg ggccccgtgc acatcgccac ccgcgccggc
    14581 cttcccgccg acggctactg cgccacctgc caccggctcg acggttcgga cgcggcacgg
    14641 gagtggaccg accgcgcggg caccggcccg gccggcgagc tgctccagtc ggccgcggtg
    14701 cacaggggcg aggcgggggg ccccgcggcg ctcgtggccc gccacggccc cgcgcgccac
    14761 gcgcacctgg tcgacccggg ccagggcccg gccgtccgcc cccggcagga gcacacgccg
    14821 tgacgacgcc gtccggcccc ctcgccgccg caccgggcgt gtgccacacc cgggcacctc
    14881 tcggagcgga actgcgcacc gtcctcgcgc tggtggcccc cgtcctgcac cacagcgccg
    14941 cccggctgtg gcagccgcag gacctgcggg cacgctatct gcgctatctc gtcacgatgc
    15001 acacggtcat ccgggcctcc gtaccgttga tggaacgggc ccgggccgcc tgccgcgacg
    15061 cgcccgccac cgacccggcg gccgggccgc tgtaccgcta cctgacggcg cacatcccgc
    15121 gcgaacgcca ccacgacacc tggctgctgc gggacatgga ggccgccggg ctccaccccg
    15181 gtcacgaact cgcccggccc ccctcaccgg aggtcgcccg gctggtcggc gcccagtact
    15241 actggatcga ccacttccac ccgctgagcc tgctcggcta tgtggcggta ctcgaactca
    15301 acgctcccgc accgtcgttg atccccctgc tggccgcccg cacgggtctg cccccggccg
    15361 ccttcgacac cctgcgcctg catgcggaga tcgacgacgg ccacagtacg gcggtgctgg
    15421 gagccctcga cgagagcgcg ccggcgccac aggtgcgggc ggcggtcagg ctgagcgcac
    15481 tgcacaccgt gacggcgctc gccgacgtac tgaactccct ggccgacctg acggaccgca
    15541 ccggtggtcc cgcggaatga gaggagccct gacatgacag cggacagcgg tggggaaagc
    15601 gccgtcgacg gcgcggggga gcacgacacc ggatccgtcc tgcgggccct ggaacaagca
    15661 ggcttccccg tgcgggcgtt caccggcgaa cagcgtgccg tcttcgccgg gctcaccccg
    15721 caggagctcg cactgatcct cgacctgaag acgcggctcg acgccgtgga gccggaagtg
    15781 caggcgcaca ccgtcgtcgc gggcgcggcc ctgttctgag cggcccgcac gagcggccgg
    15841 gcaccacggg ccgcacgagg ggccggcggc gcacgaccgg ccgtacccgc gacgacgtcc
    15901 gacggcgaac agcgagggga ccgctcatgc agcaacgcaa ggtcatcacc gcgctcttct
    15961 gcgatctggt cgggtccacc gagctgtccg ggacgctgga gccggagacg ctgcgctccg
    16021 tggtgctgcg ctacttcgac gcgatgcgcg gcgggatcga gtcgcacggg gggacggtgg
    16081 agaagttcat cggggacgcc gtgatggccg tgttcggcgt gccgcacgtc cacgaggacg
    16141 acgcgcaccg ggccgcctcg gcggccctgg agatgatcgc cgccctggac gggctcaaca
    16201 ccgagctgga ccgggacttc ggcagcaccc tcgcggtccg catcggcctg aacagcgggg
    16261 aggccgtcac ctcgcaggac ctggagaacg acggcacggt cgtctcgggc gaggtggtca
    16321 acgtcgccgc ccggctcgag caggcggcgc agcccggaca catcctcatc ggccccgcga
    16381 cccgcacgct cctgggcccc gcggcggtcg tcgaagccgt cggccccctc accctcaagg
    16441 gcaagcgcga ccccgtcgac gcgttccggc tgctccgcct cacagcccag gacgggcccc
    16501 cgggtgcggc gcggcccgct gccgacctcg tcgcacggac gcgggagtat gaccggctgg
    16561 cgacggcgtg gaggcgggct tcgcgcgacg gcaccggccg tctgatccgg ctcaccggag
    16621 acgccggcat cggcaagacg cgcctgctgc gggaatggct cgcggcccgg tccgccgagg
    16681 gctccctcgt cggcaccggc cgctgccact cctaccgcga cgaggccagc ctggccccgc
    16741 tggcggccgc gatcagggag gtgctggaca ccgcgaccgc cggaacggca ccggcggccg
    16801 tacgctccgg ggcaccgcag ggccccgccc cggcccggcc gtgggacggc gccgcctacg
    16861 aggtgctgcg cggcggactg ctcgcggacg gcacgccgag cccgtccgcc gaggcgacct
    16921 gggcggccgc cgcggcggtg ctgcgcggcc tgaccgccgt gggaccggtc gcgctcgtcc
    16981 tggacgagct ccagtgggcc cgacctcaac tcctcgaagg catagtccgg ttgaccgagg
    17041 ttctggccaa atcacccgtc ctgctgatct gctcgcagcg ccctggcgag gacgagcggc
    17101 cgaccaccgc cgacgagatc cgtctgcgcc cgctgtcccg ggccgactcg ctgcgcctgg
    17161 cccgggccct cgccggcgcc ggccccgacg acggcgtact gcacacggtc gtggagcgcg
    17221 ccgagggcaa cccgctgcac ctggaacagc tgctgaccat ggtcgaggac ggggccgacc
    17281 cgggcgggct gcccgtgacc gtcaccgccg tcctcgcggc ccgcatcgac gtcctgccgc
    17341 agccgcagcg aacggtgctc gacgcgggcg cggtgatcgg ccgccggttc accgtcgagg
    17401 aggtccgccg gctcctcgac gacccgcccg cggagaccgc cctcccggag cacacgcccg
    17461 tgacgggcgc ggtgcacgaa ctggtacgac gcggcctcgt cgaaccggct cccggggccc
    17521 cggcgacgta ccgcttcagc tccgggctgt tgcgcgacgt cacctaccgg tgcctgagca
    17581 agagccggcg ggccgcctgg cacgagcgac tggcgacccg cccaggcacc gcgcccgccc
    17641 tggcctcgca ccacctggaa gcggcctacg tgctccggcg cgacctcggg ctgcggggtg
    17701 aacacgtcga gggcctgcgg ggccgggccg ccgacgcact cagccgggcc ggccggcacg
    17761 cgctcgcccg cgccgacctg tcctggtcgg cggagctgca cgcccgttcc ctggcccact
    17821 gcgcccccgg cgaggcgcgg tggcgccatg ccgcgcaggg actgggagag acctggctgg
    17881 cactcggccg gaccggcgag ggcggggacc tgctcaccca ggtgcgtgac gcggcggcca
    17941 cggccgagga ccggctctcc ggcgcccacg ccggcctgca actggcctcc ctgtatcccg
    18001 acgcctcgcc gacggcggcc gccgacgccg cacgcgccgc actcgcggtg ttcggggagt
    18061 tcgacgaccg gctgggcctg gcacgcgccc atgtccggct cgcgcaggag cagcagtacg
    18121 ccgggcggca tcgcgccgcg agcgatctgc tggccgtcgc gctgggccac gcactggccg
    18181 ccgacgccgc gccggagcgg gcgatggcgc tcggcgcgct cggcatctcc ctgtggcacg
    18241 gacccacccc ggccggcgaa gcgatcgagc gctgccgggc cctgctcgcc gagcacggcc
    18301 ccggcaaccc cgtcgtggtg gtcgcgctga actatccgct ggcgaatctg ctcgccctgt
    18361 gcggccggac cggcgaggcg cgtggctgcc tgacggacgc ggagcggttc gccgtcgggc
    18421 tcggctacgc ggaagtggcc gcgttcgggc cgctgttcgc cgccggggtg gaggtcctcg
    18481 cgggatcgac ggcgcaggcg gagcggttgt tgcggcaggc cgtggagacg ttccgcacgg
    18541 tgggcggtcc gcagctgcac gcggccgcct gccgggacct cgcacgggtg ctcctggccc
    18601 gcggcctgcc ctggcccgcg gcgccggacg acatccgtga cgtcaccccg ggccccgagc
    18661 ccgccggtgc gggccggccg ggcgaggccg tcccggcgcc ggccatggcg ctgcccccgg
    18721 cggacgctgc cgacgacttc ggggtgcgtg ccctggccgc cgccgcggcc gggaacgccc
    18781 cagacgcgct gcggctggcc cgccgcgcgg tggcggcggc ggacaccacg gactcaccga
    18841 tcggacgcgc caccgcccgg ctcgacatgg cgcaggtcct gtacacgacg ggccgtccgc
    18901 aggccgccgt ccgcagcgcc gaccgggcgg ccctgctgtt ccgggccaag ggccatgccg
    18961 tgggagcgac ggccgcggca cacctggccg cccgggcggc cgagtcgatc ccggaccgta
    19021 ccgaggcgag cggagacggc cggtgacgaa tgcgctgagc tggggactgg gggaccggcg
    19081 gccggacgac atccgggtcc cggcggcggc catgggcggc cccgtcacgc ccgactgggc
    19141 gtggggcggc tccaccggcc gcggtgtccg ggtgtgcatc gtcgacagcg gggtggagcg
    19201 cgaccacctc atggtcgggc gggtggcgtc ggcgcacgtg gtcgtcgagg gggacgacgg
    19261 ccgcccgcgt acggtgccgt cggacagcgg cgacgcgtgc ggccacggga ccgcctgcgc
    19321 ggggatcgtc cgcgaggtcg cccccgactg cgagctgcac agcgtgcggg tgctcggcga
    19381 acggttcacc ggtaccggcg acttcctgct ggccggtctg cggtgggccg tcgaacaggg
    19441 cttcgacgtc atcaacatga gcctttcgac cacccacgaa cgcttcctgc gcgagctgca
    19501 cgagctggcc gacgaggcgt acttccgccg gtgcgtcgtc gtcgcgtcgg cgcacaacag
    19561 ccccgtggtc agcttcccct ggcggttcag ctccgtcgtc tcggtcggga gccaccagga
    19621 ggacgacacc ggactgcacc tgtacaaccc ggatccgccg gtggagttct acgccaaggg
    19681 tcaggacgta cgcgtggcgt ggctggacaa ctgcgtcacc cgcacgacgg gcaacagctt
    19741 cgccacaccg cgcgtcgcgg gactgtgcgc gctgatcctg gccaagcatc cggccctgac
    19801 cgtcttccag ctcaagaccg tgctctacct gacggcggcc aacgtccggg tgccggaccg
    19861 ggccgacggg accacgccta cgcccgccga tcctgtgacc gccgccgccg ccccgccccg
    19921 gcccgggtcc ggcgcggacc cggtgggcga cggcctcgca cacgcgcacg gtgccggccc
    19981 gccggccgcg ccgggggacg acgggcaacg ccacgacggc cggcccggat cacccccgcc
    20041 cccagaaacc gaaccggaga agtgaggtcc gcggtgtccc cgattcttcc ttccgacgac
    20101 acccacgcgc tgttgcagtc cgtggtcgac gtggcccggg ccatcttcgc cgccgccgcg
    20161 agctcggtgt tcctgctgga cgacacggcc ggcgaactgg tcttccaggc cgtctccggg
    20221 gaaggcgagg acatgctcgt cggcacccga ttcccggccc accggggcat cgccggctgg
    20281 gtggcctcct cggggcaggc gatgatcgcc gacgatctgg cgagcacccg gaccttcgcc
    20341 cgggatctcg ccgagtccac cggctacgtc ccgaacgccc tcatggccgc accgctgttg
    20401 tcgcagcaga gggtcctggg cgtcctggag gtgctcgacc cctcgccccg gccccgggcg
    20461 ggcctcgaag acctcgacct gctctccctg ttcgccgcgc aggcggccat cgccctgcgc
    20521 gtcaccggcc gttcctccgg caccggcacc acggccccgg gcgccaccga cgagcagctg
    20581 acggacgcgt tccgcgcctt cctgcgcgat cgctcccact gacggcggac cgacgaagcc
    20641 caggcgtgcc gcagttcaag ccccgacgga tgataagcat gatcatgaca atccgagagg
    20701 gcgatgtccg gttcggcggc acgccgttcg ccgctcacgt gcccgccacc ggcggcaggt
    20761 ccacggccgt caggccggtg acccggcggc cgaactcatg ggtgaacccg gacatgccgt
    20821 acgcggcgaa atgggcactg acctctcccg cgggcggcat cagcagattg cactcgtgca
    20881 actcctccac ctcggcgatc acctggtcgt accggaacgg cggagtgagc gacgacagtc
    20941 tccgataggc cagccgctgc tgctgcggaa gatcgcgcca gaaggcctcg taccgctccc
    21001 gcagcacgag ttcaccgacc gccatctcgt ccagcaggga gggagccacg ctcagccggt
    21061 cggcgtagtc ggccagccgc acatggcgca gcgattcgag tttcgcagcg atgatccgga
    21121 tggccagcgg aagcccctcg cagcactgga cgatccgccg cgccgacgcc tggtcgctca
    21181 tcacccgccc gaacccgacg atccggccca gcagttcgat cgactctccc ccctggaacg
    21241 ggggaagttc cacccgcgcc accgcctcca gcccgctgag ccggtaccgg ctggtcacca
    21301 gggtgcagct ggcaccggac ccgggcagca gcgccagcac ggtctgctgc cccacggcgt
    21361 cgtccagcac gagcaggatc cgtcggcccg ccacccaggt ccgccaccgg gccagagcct
    21421 gcgcgacgtt ctgcgtcccc ggcagaccaa cgctgtccag cagtgcccgc agcaccgacc
    21481 ccagcgggcg gttgcccagc tcggtcatga tcagcccgtc cgggaaggcg tcggcgagga
    21541 gatgcgccac ccggacggcc agcgcggact tgcccacccc cacgggcccg gacacgacca
    21601 tcacaccgct ctcccgacgg gcacggaaat acccgagcgc ccgctgcacc tcgtcggcac
    21661 ggcccacgaa gtccggcagg tcgcgcggca gttgattgcc cggccccgga cggcgctccg
    21721 gcgcgggagc ccccaggaga cgccggtgca gcgccgccag cgcgggaccc ggcgtcacgc
    21781 ccaactccct tgtcagcgcc cgccgtacgc tgtcgaagtg ggccgcggcc tcgctctgcc
    21841 ggccggtcgc cgcgagcgcc gtgatccatg cggcggcgag ccgttcgcgc aggaggtgac
    21901 gcacgacgtg ttcctggagc cggtcgagca cgagggcgtg gcggccgcgg ccgttctcca
    21961 gctccgccca gtcctccagg accgacacct gcatctcctg gagccggtcc accgccgcgg
    22021 tcagatacgg cacatcgccg aactcccgca gcgggcggtc ctgccagagt tccagggccc
    22081 tgacgagcgc gtcgcacgcg gagtccgtgt ccccgtcacg ggtgcgccgc ctgccgatcc
    22141 gggccagttc ctcgaaccgc agcagatcgc actccgacgg ttcgagccgc agcaggtatc
    22201 cgcccggcgt gtgcgtcaac cggccgccca gcacgcggcg cagacgggag acgtagacct
    22261 gaaggttctt tctcgcggtc cgcgggggcc ggccgtccca cagggcgtcg atgaggccgt
    22321 cgaccgataa cacgttgttg gcctggctga cgagaacggc cagtaacaga cgcggtttcg
    22381 gcccgccgag atcggctgtc ccgcccccgt cgacccgcac acagatttcc ccgaatgcag
    22441 tgatcaaccg attcatacat cgacattggc acaagccctt cctccccgca ggaggtcccg
    22501 accagcaagt tcctgctgtt tagacgcatg accccggcgc acgccgacac cgcctcggcg
    22561 accgcgtacg ggccgcgagt ttgcgatgat gcgactgcgg agacgcgaag ggcggacccg
    22621 gattccactc cgcccgaacg gcacatcggg aatgcatgtg tcgcacacgt tttgtccctg
    22681 tcggaacgcc gcattcagtc acctcggtgc acgacacggg cgagcggtcc cctcgccctt
    22741 cccgcaggca acggacccgg gaacccgga
//
