LOCUS       NZ_BMRD01000048         4796 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence48, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000048
VERSION     NZ_BMRD01000048.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 4796)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 4796
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000048.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..4796
                     /culture_collection="JCM:3295"
                     /db_xref="taxon:46158"
                     /mol_type="genomic DNA"
                     /organism="Actinomadura citrea"
                     /strain="JCM 3295"
                     /submitter_seqid="sequence48"
                     /type_material="type strain of Actinomadura citrea"
     gene            <1..>4796
                     /locus_tag="IEZ14_RS42245"
     region          1..4796
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..4796
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..4796
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:>4796](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..>4796
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS             1..>4796
                     /NRPS_PKS="Domain: AMP-binding (1-309). E-value: 3.4e-73.
                     Score: 238.5. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS42245_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (412-481). E-value: 1.1e-28. Score:
                     91.2. Matches aSDomain: nrpspksdomains_IEZ14_RS42245_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (495-794). E-value:
                     3.8e-114. Score: 372.7. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS42245_Condensation_LCL.1"
                     /NRPS_PKS="Domain: PCP (1029-1097). E-value: 2.1e-27.
                     Score: 87.1. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS42245_PCP.2"
                     /NRPS_PKS="Domain: Condensation_LCL (1114-1413). E-value:
                     2.1e-112. Score: 367.0. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS42245_Condensation_LCL.2"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047: phosphopantetheine-binding domain-containing
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852240.1"
                     /locus_tag="IEZ14_RS42245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_229810786.1"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-86, bitscore:
                     275.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 7.8e-75, bitscore:
                     237.8, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6.6e-20, bitscore:
                     57.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAYMLEDAAPACVITTSGADLPGTTPRVELDALSLDGLCGDDVT
                     DAERARPLRPANPAYVIYTSGSTGRPKGVVVSHANVVDFCAESMASYGPARMARVLFST
                     SLNFDVSVFEWLVPLTVGGEIEVVRDLLEVAERGGWSGTLVSGVPSAVSALLARGGLRL
                     EAGDVALGGEALPPQLVRDVRALLPDARVSNIYGPTEATIFVTGWYDDGNTEGLAPIGR
                     PMANTRAYVLDDRLGPVPVGVPGELYLAGDGLARGYLRRPGLTADRFVACPFGGPGERM
                     YRTGDLVRWNRAGHIEYLGRLDHQVKVRGFRIEPGEIETALSAHPAVTQSVVLARRDAV
                     GDTVLAGYVVGSASPAELRAFVAGTLPDYMVPSAIVVLEEMPLTPNGKLDRAALPEPDL
                     AASLTARGPRDAREEILCGIFADVLGLERVGVDDGFFDHGGDSLKATRVVARARAALDV
                     ELPVRALFEAPTVAGLAEYIASAGGAGRPALLAAERPAPLPVSYAQERLWFLNRLEGLT
                     ATYNMPIPLRLTGAVDPEAMRDALRDVVARHEPLRTLFADADGEPHQVIVAPDEADPRL
                     TVSEPADLRAALFADATRGFDLAAEPPVRAHLYRLGEDEHLLLVVLHHIAGDGWSMAPL
                     ARDVITAYLARRDGGAPGWAPLPVQYADYALWQRGLLGDERDPASLAARQIAYWKDALA
                     GLPDQIRLPHDRPRPDRASYRGGQIAFEVPAELAEGLRALARDHQVSVFMVLQAALAAL
                     LTRLGAGTDVPIGSPIAGRTDEALDDLVGVFVNTLVLRTDTSGDPSLAELLARVRETDL
                     AAYAHQDVPFERLVEVLNPARSLARHPLFQVMLTLQNNPEASVELPGLNVAVEPVDAGV
                     AKFDLEFLLEDARDRAGGYAGTLEYALDLFDRETAERLAGWYRRTLEAAVASGGAVTVG
                     ALDLPGAPQDLTQAPRSAEGPSEKRLVAYVVAAPGQTLDPEELRAHLRESLPESMVPAA
                     VVVLDEMPLTPNGKVDARALPKPQLTIAPATAYRTPSGEAEEAVAAVFADLLGVDRVGA
                     DDDFFALGGNSLIAMRVVSRVRRALDVELPVRALFEAPTVASLAALLGRGAAPVRPALE
                     PRERPGVIPPSYAQQRLWFLSRFEGPSATYNMPTALRIRGPLDVDALRAAVGDLVERHE
                     SLRTILPDSGGVPRQLILDAAAARPELEIADTTEAELPARLAMAAGYAFDISAEPPLRT
                     HLFRVGPREHVALLLMHHIGGDGWSMAPLARDFITAYAARAGGTAPEWAPLPVQYADYT
                     LWQQDLFGSEDDPGSLISQQIAYWREALAGLPEELPLPADRPRPAQSSYRGGTARFRLG
                     AEVRGRLQKIAQETGASPFMVAQAAFAALLTRLGAGTDVPIGSPIAGRTDEALDDLVGM
                     FVNMLVFRTDTSGDPSFRELVGRVKETDLAAYAHQDVPFERLVEVLNPPRHLARHPLFQ
                     VGLTFQNNPEARLEMPGFSAELEPLTSAVSRFDLLMILTEREDGFDGELEYALDLYDPA
                     TARGLVERFERYLESLLAEPDAPIGAADVLSPRERSLVLGDWAGGSARPAERSTIPALF
                     EEQAAVRPGAVAVSFEGVS"
     aSDomain        4..927
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS42245_AMP-binding.1"
                     /evalue="3.40E-73"
                     /label="IEZ14_RS42245_AMP-binding.1"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="309"
                     /protein_start="1"
                     /score="238.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VAYMLEDAAPACVITTSGADLPGTTPRVELDALSLDGLCGDDVTD
                     AERARPLRPANPAYVIYTSGSTGRPKGVVVSHANVVDFCAESMASYGPARMARVLFSTS
                     LNFDVSVFEWLVPLTVGGEIEVVRDLLEVAERGGWSGTLVSGVPSAVSALLARGGLRLE
                     AGDVALGGEALPPQLVRDVRALLPDARVSNIYGPTEATIFVTGWYDDGNTEGLAPIGRP
                     MANTRAYVLDDRLGPVPVGVPGELYLAGDGLARGYLRRPGLTADRFVACPFGGPGERMY
                     RTGDLVRWNRAGHIEYLGRLDHQVKVR"
     aSModule        4..1443
                     /complete
                     /domains="nrpspksdomains_IEZ14_RS42245_AMP-binding.1"
                     /domains="nrpspksdomains_IEZ14_RS42245_PCP.1"
                     /locus_tags="IEZ14_RS42245"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       175..234
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0001"
                     /evalue="4.50E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="78"
                     /protein_start="58"
                     /score="34.4"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVVVSH"
     CDS_motif       718..807
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0002"
                     /evalue="4.60E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="269"
                     /protein_start="239"
                     /score="54.1"
                     /tool="antismash"
                     /translation="PVGVPGELYLAGDGLARGYLRRPGLTADRF"
     CDS_motif       892..957
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0003"
                     /evalue="2.20E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="319"
                     /protein_start="297"
                     /score="38.8"
                     /tool="antismash"
                     /translation="YLGRLDHQVKVRGFRIEPGEIE"
     aSDomain        1237..1443
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS42245_PCP.1"
                     /evalue="1.10E-28"
                     /label="IEZ14_RS42245_PCP.1"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="481"
                     /protein_start="412"
                     /score="91.2"
                     /tool="antismash"
                     /translation="EEILCGIFADVLGLERVGVDDGFFDHGGDSLKATRVVARARAALD
                     VELPVRALFEAPTVAGLAEYIASA"
     aSDomain        1486..2382
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS42245_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.80E-114"
                     /label="IEZ14_RS42245_Condensation_LCL.1"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="794"
                     /protein_start="495"
                     /score="372.7"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIAGDG"
                     /tool="antismash"
                     /translation="APLPVSYAQERLWFLNRLEGLTATYNMPIPLRLTGAVDPEAMRDA
                     LRDVVARHEPLRTLFADADGEPHQVIVAPDEADPRLTVSEPADLRAALFADATRGFDLA
                     AEPPVRAHLYRLGEDEHLLLVVLHHIAGDGWSMAPLARDVITAYLARRDGGAPGWAPLP
                     VQYADYALWQRGLLGDERDPASLAARQIAYWKDALAGLPDQIRLPHDRPRPDRASYRGG
                     QIAFEVPAELAEGLRALARDHQVSVFMVLQAALAALLTRLGAGTDVPIGSPIAGRTDEA
                     LDDLVGVFVNTLVLRTDT"
     aSModule        1486..3291
                     /domains="nrpspksdomains_IEZ14_RS42245_Condensation_LCL.1"
                     /domains="nrpspksdomains_IEZ14_RS42245_PCP.2"
                     /incomplete
                     /locus_tags="IEZ14_RS42245"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1501..1533
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0004"
                     /evalue="5.60E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="511"
                     /protein_start="500"
                     /score="9.4"
                     /tool="antismash"
                     /translation="SYAQERLWFLN"
     CDS_motif       1552..1668
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0005"
                     /evalue="2.00E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="556"
                     /protein_start="517"
                     /score="55.6"
                     /tool="antismash"
                     /translation="ATYNMPIPLRLTGAVDPEAMRDALRDVVARHEPLRTLFA"
     CDS_motif       1864..1929
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0006"
                     /evalue="8.50E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="643"
                     /protein_start="621"
                     /score="31.1"
                     /tool="antismash"
                     /translation="LHHIAGDGWSMAPLARDVITAY"
     CDS_motif       1978..2013
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0007"
                     /evalue="6.60E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="671"
                     /protein_start="659"
                     /score="18.6"
                     /tool="antismash"
                     /translation="QYADYALWQRGL"
     CDS_motif       2284..2373
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0008"
                     /evalue="9.10E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="791"
                     /protein_start="761"
                     /score="43.8"
                     /tool="antismash"
                     /translation="DVPIGSPIAGRTDEALDDLVGVFVNTLVLR"
     CDS_motif       2422..2541
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0009"
                     /evalue="5.70E-24"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="847"
                     /protein_start="807"
                     /score="76.6"
                     /tool="antismash"
                     /translation="RETDLAAYAHQDVPFERLVEVLNPARSLARHPLFQVMLTL"
     aSDomain        3088..3291
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS42245_PCP.2"
                     /evalue="2.10E-27"
                     /label="IEZ14_RS42245_PCP.2"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="1097"
                     /protein_start="1029"
                     /score="87.1"
                     /tool="antismash"
                     /translation="EEAVAAVFADLLGVDRVGADDDFFALGGNSLIAMRVVSRVRRALD
                     VELPVRALFEAPTVASLAALLGR"
     aSDomain        3343..4239
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS42245_Condensation_LCL.2
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.10E-112"
                     /label="IEZ14_RS42245_Condensation_LCL.2"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="1413"
                     /protein_start="1114"
                     /score="367.0"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIGGDG"
                     /tool="antismash"
                     /translation="IPPSYAQQRLWFLSRFEGPSATYNMPTALRIRGPLDVDALRAAVG
                     DLVERHESLRTILPDSGGVPRQLILDAAAARPELEIADTTEAELPARLAMAAGYAFDIS
                     AEPPLRTHLFRVGPREHVALLLMHHIGGDGWSMAPLARDFITAYAARAGGTAPEWAPLP
                     VQYADYTLWQQDLFGSEDDPGSLISQQIAYWREALAGLPEELPLPADRPRPAQSSYRGG
                     TARFRLGAEVRGRLQKIAQETGASPFMVAQAAFAALLTRLGAGTDVPIGSPIAGRTDEA
                     LDDLVGMFVNMLVFRTDT"
     CDS_motif       3352..3381
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0010"
                     /evalue="5.00E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="1127"
                     /protein_start="1117"
                     /score="9.5"
                     /tool="antismash"
                     /translation="SYAQQRLWFL"
     CDS_motif       3403..3513
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0011"
                     /evalue="7.60E-20"
                     /label="C2_LCL_024-062"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="1171"
                     /protein_start="1134"
                     /score="63.3"
                     /tool="antismash"
                     /translation="ATYNMPTALRIRGPLDVDALRAAVGDLVERHESLRTI"
     CDS_motif       3721..3786
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0012"
                     /evalue="3.90E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="1262"
                     /protein_start="1240"
                     /score="25.8"
                     /tool="antismash"
                     /translation="MHHIGGDGWSMAPLARDFITAY"
     CDS_motif       3835..3870
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0013"
                     /evalue="1.20E-03"
                     /label="C4_LCL_164-176"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="1290"
                     /protein_start="1278"
                     /score="11.6"
                     /tool="antismash"
                     /translation="QYADYTLWQQDL"
     CDS_motif       4141..4230
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0014"
                     /evalue="6.90E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="1410"
                     /protein_start="1380"
                     /score="44.1"
                     /tool="antismash"
                     /translation="DVPIGSPIAGRTDEALDDLVGMFVNMLVFR"
     CDS_motif       4279..4395
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS42245_0015"
                     /evalue="1.70E-21"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IEZ14_RS42245"
                     /protein_end="1465"
                     /protein_start="1426"
                     /score="68.6"
                     /tool="antismash"
                     /translation="KETDLAAYAHQDVPFERLVEVLNPPRHLARHPLFQVGLT"
ORIGIN
        1 cgtgtcgcct acatgctgga ggacgcggct ccggcctgcg tcatcacgac gtccggcgcc
       61 gacctgcccg gcaccactcc gcgcgtcgaa ctcgacgcgc tgtcgctgga cgggctgtgc
      121 ggcgacgacg tcaccgacgc cgaacgcgcc cggccgctgc gccccgcgaa ccccgcctac
      181 gtcatctaca cgtccgggtc gacgggacgc cccaagggcg tcgtcgtctc ccacgccaac
      241 gtcgtggact tctgcgccga gtcgatggcg agctacgggc ccgcccggat ggcgcgcgtg
      301 ctgttctcga cgtcgctgaa cttcgacgtg tcggtgttcg agtggctcgt gccgctcacc
      361 gtcggcggcg agatcgaggt cgtccgcgac ctgttggagg tcgccgagcg cggcggctgg
      421 tccgggacgc tcgtcagcgg cgtgccgtcc gcggtgtcgg cgctgctggc gcgcggcggt
      481 ctgcggctgg aggcggggga cgtggcgctc ggcggcgagg cgctgccgcc gcagctcgtc
      541 cgggacgtcc gggcgctgct gccggacgcc cgcgtctcca acatctacgg ccccaccgag
      601 gcgacgatct tcgtcaccgg gtggtacgac gacggcaaca ccgagggcct ggcgccgatc
      661 ggccgaccga tggccaacac ccgcgcctac gtgctggacg accggctcgg ccccgtccct
      721 gtcggcgtgc ccggcgagct gtacctcgcg ggcgacgggc tggcgcgcgg ctacctgcgc
      781 cgccccggcc tgaccgccga ccggttcgtc gcgtgcccgt tcggcgggcc gggggagcga
      841 atgtaccgga cgggcgacct cgtccgctgg aaccgcgccg gccacatcga gtacctcggc
      901 cgcctcgacc accaggtcaa ggtccgcggc ttccggatcg agccgggcga gatcgagacg
      961 gcgctgtccg cgcaccccgc cgtcacgcag agcgtcgtgc tcgcgcgccg ggacgcggtc
     1021 ggcgacaccg tcctcgccgg ctacgtcgtc ggctccgcga gcccggccga gctgcgcgcg
     1081 ttcgtcgccg ggacgctgcc ggactacatg gtcccctccg cgatcgtcgt gctggaggag
     1141 atgccgctca ccccgaacgg caagctcgac cgcgccgcgc tccccgagcc ggacctcgcc
     1201 gcctccctca ccgcccgcgg cccccgcgac gcccgcgagg agatcctctg cgggatcttc
     1261 gccgacgtcc tgggcctgga gcgggtcggc gtcgacgacg ggttcttcga ccacggcggc
     1321 gactccctca aggcgacccg cgtcgtcgcc cgcgcccgcg ccgcgctgga cgtggagctg
     1381 ccggtccggg cgctgttcga ggccccgacc gtcgcgggcc tcgccgagta catcgcctcc
     1441 gccggaggcg ccgggcgccc cgcgctgctg gcggccgagc gccccgcccc gctgccggtg
     1501 tcgtacgcgc aggagcggct ctggttcctg aaccggctcg aagggctcac cgccacctac
     1561 aacatgccga tcccgctgcg cctcaccggc gcggtcgacc ccgaggcgat gcgggacgcg
     1621 ctgcgcgacg tcgtcgcccg ccacgagccg ctgcggacgc tgttcgccga cgccgacggc
     1681 gaaccgcacc aggtgatcgt cgcgccggac gaggccgacc cgcgcctgac ggtcagcgag
     1741 cccgccgacc tgcgcgccgc cctcttcgcg gacgccaccc gcggcttcga cctggcggcc
     1801 gagccaccgg tgcgcgccca cctctaccgg ctcggcgagg acgagcacct gctgctcgtc
     1861 gtcctgcacc acatcgccgg cgacggctgg tcgatggcgc cgctcgcccg cgacgtcatc
     1921 accgcctacc tggcccgccg cgacggcggc gcccccggct gggcgccgct gcccgtccag
     1981 tacgccgact acgcgctctg gcagcgcggc ctgctcggcg acgagcgcga cccggcgagc
     2041 ctcgccgccc gccagatcgc ctactggaag gacgcactcg ccgggctgcc cgaccagatc
     2101 aggctgccgc acgaccgccc ccgtcccgac cgcgcgtcct accggggcgg ccagatcgcc
     2161 ttcgaggtcc cggcggagct cgcggaaggg ctgcgcgccc tcgcccgcga ccaccaggtc
     2221 agcgtgttca tggtgctgca ggccgcgctc gccgcgctgc tcacgcgcct cggcgccggg
     2281 acggacgtgc cgatcggctc gcccatcgcc ggccgcaccg acgaggccct ggacgacctc
     2341 gtcggcgtct tcgtcaacac gctggtgctg cgcaccgaca cctccggcga cccgtcgctc
     2401 gccgagctgc tcgcccgcgt ccgggagacc gacctcgccg cctacgccca ccaggacgtc
     2461 cccttcgagc ggctcgtcga ggtgctcaac ccggcgcggt cgctggcgcg gcacccgctg
     2521 ttccaggtca tgctgaccct gcagaacaac cccgaggcgt cggtcgagct gccgggcctg
     2581 aacgtcgccg tcgagccggt ggacgccggg gtcgccaagt tcgacctgga gttcctcctg
     2641 gaggacgccc gcgaccgcgc gggcgggtac gcggggaccc tcgaatacgc cctcgacctg
     2701 ttcgaccgcg aaaccgccga gcggctcgcc ggctggtacc ggcggaccct ggaggcggcc
     2761 gtcgcctccg gcggcgccgt caccgtcggc gccctcgacc tgcccggagc tccgcaggac
     2821 ctcacccagg ccccgcggtc ggcggagggt ccgagcgaga agcgcctcgt cgcgtacgtc
     2881 gtcgccgcgc ccggccagac cctcgacccc gaggagctgc gcgcccacct ccgcgagagc
     2941 ctgccggagt cgatggtgcc cgccgccgtc gtcgtcctgg acgagatgcc gctcaccccg
     3001 aacggcaagg tcgacgccag ggcactgccg aagccgcaac tgacgatcgc cccggcgacc
     3061 gcgtaccgca ccccgtcggg ggaggcggag gaggccgtcg ccgccgtctt cgccgacctg
     3121 ctcggcgtgg accgggtcgg cgccgacgac gacttcttcg cgctcggcgg caactccctc
     3181 atcgcgatgc gggtcgtcag ccgggtccgc cgcgccctcg acgtcgagct gcccgtgcgg
     3241 gcgctgttcg aggccccgac cgtcgcgagc ctcgccgccc tgctcggccg cggcgccgcg
     3301 cccgtgcgcc ccgcgctgga gccgcgcgag cgcccgggcg tgatcccccc gtcctacgcc
     3361 cagcagcggc tctggttcct cagccggttc gaggggccgt ccgccaccta caacatgccg
     3421 accgccctgc gcatccgcgg cccgctggat gtggacgcgc tccgcgccgc cgtcggagac
     3481 ctcgtcgaac ggcacgagtc gctccgcacg atcctgcccg acagcggggg agtgccgcgc
     3541 cagctcatcc tggacgcggc cgcggcgcgg cccgagctgg agatcgccga caccaccgag
     3601 gcggagctgc cggcgcggct cgcgatggcc gccggatacg ccttcgacat ctccgccgag
     3661 ccgccgctgc gcacccacct gttccgggtc gggccgcggg agcacgtcgc gctgctgctc
     3721 atgcaccaca tcggcggcga cggctggtcg atggcgccgc tcgcccgcga cttcatcacc
     3781 gcctacgcgg cccgcgccgg cggcacggcc ccggaatggg cgccgctgcc cgtccagtac
     3841 gccgactaca cgctctggca gcaggacctg ttcggttccg aggacgatcc cggcagcctg
     3901 atctcgcagc agatcgcgta ctggcgcgag gcgctggcgg ggctgccgga ggagctgccg
     3961 ctgcccgccg accggccgcg ccccgcgcag tcgtcctacc ggggcgggac ggcccgcttc
     4021 cggctcggcg ccgaggtccg cgggcgcctg cagaagatcg cacaggagac cggcgccagc
     4081 ccgttcatgg tcgcccaggc cgcgttcgcg gcgctgctca cgcggctcgg cgcggggacg
     4141 gacgtgccga tcggctcgcc gatcgcgggc cggaccgacg aggctctgga cgatctggtc
     4201 ggcatgttcg tcaacatgct cgtcttccgc accgacacct cgggcgaccc gtcgttccgg
     4261 gagctggtgg gacgggtgaa ggagaccgac ctcgccgcct acgcgcacca ggacgtcccg
     4321 ttcgagcggc tcgtcgaggt gctcaacccg ccccgccacc tggcccgcca cccgctgttc
     4381 caggtcgggc tgacgttcca gaacaacccg gaggcgcggc tggagatgcc cgggttcagc
     4441 gccgagctgg aaccgctcac ctccgcagtg tcccgattcg acctgctgat gatcctcacc
     4501 gagcgggagg acggattcga cggcgagctg gagtacgcgc tcgacctcta cgacccggcc
     4561 accgcgcgcg gcctcgtcga gcggttcgag cggtacctgg agtcgctgct cgccgaaccc
     4621 gacgccccca tcggcgccgc cgacgtcctg tcgccgcggg aacgctcgct ggtcctcggc
     4681 gactgggcgg gcggctccgc gcgccccgcc gagcggtcca cgatccccgc gctgttcgag
     4741 gagcaggcgg cggttcgtcc gggtgcggtg gcggtgtcgt tcgagggtgt gtcgtg
//
