LOCUS       NZ_BMRD01000037        22800 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence37, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000037
VERSION     NZ_BMRD01000037.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 22800)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 22800
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000037.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     protocluster    1..22800
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[8576:18717]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8577..18717
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            <1..423
                     /locus_tag="IEZ14_RS40490"
     CDS             <1..423
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622790.1"
                     /locus_tag="IEZ14_RS40490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_229810771.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.2e-16, bitscore:
                     49.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="TTAAAEGIRLVVVLVQNHGYASIGNLSESVGAQRFGTRHRLRTPT
                     GLDGDPIPLDLAANAASLGADVIRADDADGFRKALRQAIASPRTTVVHVETDPLAAGPG
                     SEAWWDVPVAEVSELDDTRRARAHYDDSKKTQRRYL"
     source          1..22800
                     /culture_collection="JCM:3295"
                     /db_xref="taxon:46158"
                     /mol_type="genomic DNA"
                     /organism="Actinomadura citrea"
                     /strain="JCM 3295"
                     /submitter_seqid="sequence37"
                     /type_material="type strain of Actinomadura citrea"
     region          1..22800
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..22800
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     gene            431..1915
                     /locus_tag="IEZ14_RS40495"
                     /old_locus_tag="GCM10010177_81870"
     CDS             431..1915
                     /EC_number="1.2.1.-"
                     /GO_function="GO:0018478 - malonate-semialdehyde
                     dehydrogenase (acetylating) activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608045.1"
                     /locus_tag="IEZ14_RS40495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81870"
                     /product="CoA-acylating methylmalonate-semialdehyde
                     dehydrogenase"
                     /protein_id="WP_373292922.1"
                     /sec_met_domain="Aldedh (E-value: 3.7e-145, bitscore:
                     474.2, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMRSIQHWIGGVPVGGSTSAAVHDPATGLQSGEVVLGRRAEVDLA
                     VGAAARAFESWSEVSLSRRAQIMFALRDLLERHEDELARLVTAEHGKVLDDARGEVVRG
                     REVVEFACGIAQVLKGEYSDQVSSGVDAFSFRQPLGVCAGVVPFNFPVMVPLWMHPIAI
                     ACGNTFVLKPSERVPSASNLVAELYAQAGLPDGVFNVLHGDHETADALITHPGVAAVSF
                     VGSTPVARHVHEAASSAGKRVQALGGAKNHAVVLPDADLDLAADQITAAAYGSAGQRCM
                     AVSVAVAVGAAADPLIERLAARARAIRVGPGDDPASEMGPVISEAARQRVTGHVEDAER
                     AGAKLVVDGRGAAGPGFFVGPCLLDGVATGMAAYQEEIFGPVLLVLRAETLDEAIALIN
                     ANPYGNGTAIFTSSGEAARRFQRAVHVGMIGVNVPIPVPMAFYSFGGWKASLFGDTHVH
                     GAEGVRFYTRAKAVTSRWPAPVVADGASSMAFPTAR"
     gene            complement(1889..2539)
                     /locus_tag="IEZ14_RS40500"
                     /old_locus_tag="GCM10010177_81880"
     CDS             complement(1889..2539)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017604941.1"
                     /locus_tag="IEZ14_RS40500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81880"
                     /product="isochorismatase family protein"
                     /protein_id="WP_179835459.1"
                     /transl_table=11
                     /translation="MSDDLAAGYRASGFGRGLGCGRSPAVLAVDLVRAYLVDGSPLRAP
                     VEEAVAAAATLVDAGRAAGLPVLFTRVKYQPGGADGGLFRRKIPALRVFEEGSPLGDFA
                     EGAAPRAGETVVTKQYASAFHGTSLAATLTASGIDTVLVCGLTTSGCIRATATDALQHG
                     FRPLVVDEACGDRDRRLHEANLLDLGAKYADVLSLDEALTTVRGSSSGRGEGH"
     gene            complement(2536..4437)
                     /locus_tag="IEZ14_RS40505"
                     /old_locus_tag="GCM10010177_81890"
     CDS             complement(2536..4437)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546067.1"
                     /locus_tag="IEZ14_RS40505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81890"
                     /product="hydantoinase B/oxoprolinase family protein"
                     /protein_id="WP_179835458.1"
                     /transl_table=11
                     /translation="MAEILQTATAPAGRVDVDPVTLDIIENALRNARHEMDEVLFRTAL
                     SPGIREQHDEFPLIAGPSGKMVVGQFGLSVPDFLENFDGTIGEGDILMTSDPYACGAAI
                     SHANDWLLVVPIFHEGRLVGWSSMFGHMSDVGGKTPSSMPADARTIYEEGVVVPPFKLY
                     EGGRLNEPALRIILNQVRMPDWNRADLNGLVAACTTAARRVSELCARFGVETYLSALDA
                     LLDRNYQAMKVLLATLFEDGRTLEFADYICDDGCGYGPYELKISLTRTGEKIHLDFSHA
                     APQAVGPVNYFINENLVRMFFGIYVITVADPQILWNDGFYPLIDVTIPEDSFWKPRHPA
                     ALNARNHGIGRVFDLFGGLLGQTNPEILNAAGFSSSPHFMYSGHYGSGPREGEWFQLYS
                     IGFGGVPGRPVGDGPDGHSLWPSFVNIPCEYLESYYPLRVERWETIADSGGAGLHRGGN
                     GVDVAYCFEEPGTIAIHDDRWLTYPWGVNGGRPGERGRKWIERADGTREVLPSKIHDVV
                     VGPGDVLHFVTWGGGGWGDPLARPAELVALEVLRGLVTADGARAGYGVVCTAEGVLDEE
                     ATDLLRARMAEERTEIPVFDMGPPLAEILARCEEETGLPAPRPPVDVRSAAALRDRR"
     gene            complement(4437..6500)
                     /locus_tag="IEZ14_RS40510"
                     /old_locus_tag="GCM10010177_81900"
     CDS             complement(4437..6500)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546068.1"
                     /locus_tag="IEZ14_RS40510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81900"
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="WP_179835457.1"
                     /transl_table=11
                     /translation="MGYRLGVDVGGTFTDVLLVDERTGVSHRAKTASTPADQSEGVLNG
                     IRKVCRDAGIEMHEVAHVLHGTTVATNAILQGRGARVGLVTTEGFRQVLQIGRSFVPGG
                     LAGWIIWPKPEPLARLEHTVEIPGRIAADGTVVAPLDEDRARAELRRLGGAGIEALTVS
                     LINSYANDAHERRVAELAAEELPGVPVSLSSHVLPEMREYERTVTTVANSYVQPEVSRY
                     VGNLDRSLSGSGIDAPLSVLRSDGGLTKAAKAAEDPVSLLLSGPAGGVTGAVWFAEQAG
                     FPDFLTFDMGGTSTDVALVLGGRPRIGRETTVGDLTVRATSVDVRTVGAGGGSIAHVPE
                     LTRALRVGPQSAGADPGPAAYGAGGTDPTVTDANVVLGHLPTRLAGGEIALDAEAARKA
                     MRSVADAMGLPSVEAAAAGVIDIVNENMLGALRLISVRQGYDPRDFALMSFGGAGPLHA
                     NALGRLTGSWPVIVPPSPGVLCAYGDATTCPRDESARTMVRRFSTLDDDELRAALAELA
                     DAAAGRLEAEGVPRESQTATYQIDLRYHGQGFEIPVELDRATVDGDLLAGLGAAFDAEH
                     ERLFSFLLGNEREVINLRVTVSGPRPEVAWRVLPEGSGDPSAALVRETEVWMDGATTSA
                     RVYDRSRLLSGDVVAGPAVVVEMDSTTLVLAGHAATVHPSGSLLIRPLNEEG"
     gene            complement(6521..7744)
                     /locus_tag="IEZ14_RS40515"
                     /old_locus_tag="GCM10010177_81910"
     CDS             complement(6521..7744)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893067.1"
                     /locus_tag="IEZ14_RS40515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81910"
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_179835456.1"
                     /transl_table=11
                     /translation="MSTHDGAAPDTRGPLADLRVVEMGQLLAGPFCGQLLGDFGAEVIK
                     LESPGAGDPMRQWGREKPHGKSLWWPVVARNKKSVTCDLRTPEGQDLARRIIERADIVV
                     ENFRPGTLERWGMDFDRLRETNHGLVLVRVSGFGQTGPYAPRAGYGSIGEAMGGIRYVT
                     GDPGGAPARAGISLGDSLAAVFATIGALVAVHHRNVTGRGQVVDSAIYEAVLAMMESLL
                     PEWAVAGYQRERTGSVLPNVSPSNVYPTASGEMILIAANQDTVFGRLARTMGRPELSAD
                     PRYAGHADRGRNMAELDEIISAWSARIETEDLLERLHAGGVPAGRIYTAKDMFDDPHFA
                     AREAIVRLVHPDFGELPMHNAFPRLSETPGAVRRPGPGLGEHNREVYGGLLDLPEDEIA
                     ALSERGVI"
     gene            complement(7745..8464)
                     /locus_tag="IEZ14_RS40520"
                     /old_locus_tag="GCM10010177_81920"
     CDS             complement(7745..8464)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019349.5"
                     /locus_tag="IEZ14_RS40520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81920"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_179835455.1"
                     /transl_table=11
                     /translation="MVRAVDRVYTRLRADILAGVHPPGARLGEAELAEATGSSRTPVRE
                     ALRRLEVEGLVEVLPHRGARVPDWTPEDLEEIYDLRMLLESAAAGRAATRVTAADLDRM
                     DELCRLMEAAVEPGPGQDLDRVAEFNAEFHDIVRAAASSGRLVSMLNAVVQLPLVMRTF
                     HRYSPADLARSSAHHRELAAALRARDGTWAESVMRAHVLAAKAVLLRAARAPDDRDDPS
                     KWNDPSNRNDDTETRTG"
     misc_feature    complement(8438..8451)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.07"
                     /tool="antismash"
     gene            8577..9470
                     /locus_tag="IEZ14_RS40525"
                     /old_locus_tag="GCM10010177_81930"
     CDS             8577..9470
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893063.1"
                     /locus_tag="IEZ14_RS40525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81930"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_329089758.1"
                     /sec_met_domain="HMGL-like (E-value: 6.2e-40, bitscore:
                     127.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVELIEVAPRDGLQNESAVLATADKVRLIERSVEAGLRRIEAVSF
                     VNPKRVPQMADAEAVMERLPRPEGVGYAGLVLNRRGLDRALAAGVDEINVVVVATDEFS
                     RRNQGCTVEEGAAAWAAIAADARAAGVRRTVTIAAAFGCPFEGEVPASRVLDLVRRVAE
                     SEPDEIAVADTIGVGVPAQVRALLTGAAGIAPGVPLRCHFHNTRNTGYANALTALDCGV
                     SALDASAGGFGGCPFAPAATGNIATEDLLYALDRSGVDTGVRMSAVAETAAWLGERLGK
                     PVPALLGRAGPFPAAP"
     gene            complement(9495..10844)
                     /locus_tag="IEZ14_RS40530"
                     /old_locus_tag="GCM10010177_81940"
     CDS             complement(9495..10844)
                     /GO_function="GO:0004834 - tryptophan synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006568 - tryptophan metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009081531.1"
                     /locus_tag="IEZ14_RS40530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81940"
                     /product="TrpB-like pyridoxal phosphate-dependent enzyme"
                     /protein_id="WP_179835453.1"
                     /sec_met_domain="PALP (E-value: 3.9e-44, bitscore: 141.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREAFELDRDRVPTHWYNILADLPIEVPPARPAPPRSGDAAPLQP
                     QLPLSMYRQSIGRERYVEIPGPVRSEYQRWRPTPLFRASRLESALDTPAHIYVKYEGTS
                     PSGSHKINTALAQAFYYGRSGVREMVTGTGAGQWGTALAMACHPYGMACTVFMVRSSYE
                     QKPYRGTLMRLNGAEVIPSPSTRTEVGRAALRADPRSPGTLGIANAEAIEYANGRREAR
                     FSIGSGENHVLMHQTVIGEEALLQMKLAGEFPDVVIGAMGAGSNFAGLTFPFYRAALTE
                     NTATRFLAVEPDACPKMTRGSYMMDYTDYSGVTPAVKMYTLGHTFTAYHIHAGGLRYHG
                     AAPIVSAMYDHGMVEATSYSQSRVFESGAAFAKAEGLVPAPESAHAVAAAIDEAVRARE
                     EDRERVVLVGLSGHGLLDLGAYESHLSGETVDVAPTDEEIKASLRLIESL"
     gene            complement(10846..11130)
                     /locus_tag="IEZ14_RS40535"
                     /old_locus_tag="GCM10010177_81950"
     CDS             complement(10846..11130)
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (11-83). E-value: 6e-12.
                     Score: 37.7. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS40535_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.5"
                     /locus_tag="IEZ14_RS40535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81950"
                     /product="acyl carrier protein"
                     /protein_id="WP_179835452.1"
                     /sec_met_domain="PP-binding (E-value: 1.2e-12, bitscore:
                     38.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRANNVDLAARIKSIMIRVLDLDITPERLDEKVSLYSPIVGMDS
                     LSLLHTLVEIEKEFDIEIDDEDVMLAELRNVGSLVDMISGIIEAEGGKA"
     aSDomain        complement(10882..11097)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS40535_PP-binding.1"
                     /evalue="6.00E-12"
                     /label="IEZ14_RS40535_PP-binding.1"
                     /locus_tag="IEZ14_RS40535"
                     /protein_end="83"
                     /protein_start="11"
                     /score="37.7"
                     /tool="antismash"
                     /translation="RIKSIMIRVLDLDITPERLDEKVSLYSPIVGMDSLSLLHTLVEIE
                     KEFDIEIDDEDVMLAELRNVGSLVDMI"
     misc_feature    11108..11123
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.89"
                     /tool="antismash"
     misc_feature    complement(11529..11541)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    11620..11636
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.24"
                     /tool="antismash"
     gene            11660..12838
                     /locus_tag="IEZ14_RS40540"
                     /old_locus_tag="GCM10010177_81960"
     CDS             11660..12838
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.5"
                     /locus_tag="IEZ14_RS40540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81960"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_179835451.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.1e-24, bitscore:
                     77.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.4e-27, bitscore:
                     84.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.5e-38, bitscore:
                     122.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFEWDGGQDGLYRVFRAFGEEALSKDVTERDRAGVFGRDDWSRC
                     AEQGVLGLILPSEYGGSGCGPLDYVHAMEGLGHGCLDNGLMMAIGAHILAVEVPVWKFG
                     DEEQRRRYLPELAAGRLIGANAMTEPGSGSDALALATTAERDGDSYLLTGRKRYVTNAP
                     VADVFIVYATVDPELGFTGVTAFLVERGDPGVSVKEQAEKMGLRTARWGEVELDACRIP
                     ASRRLGAERQGSAVFARTMAWERALLLAPWLGVMRREIEECTRFCRRRRQFGKHIGSYQ
                     SVSNRIVDMRIRWEISRMLVRRAAAELDGPEATIFPEVGKLYASEAAAEIFTSAMQVYG
                     ALGYSSEGRAERNLRDALGMTISSGTSDMQRVIISGKLGLAWPDTGGSGEER"
     gene            12835..14400
                     /locus_tag="IEZ14_RS40545"
                     /old_locus_tag="GCM10010177_81970"
     CDS             12835..14400
                     /NRPS_PKS="Domain: AMP-binding (8-425). E-value: 1.1e-96.
                     Score: 315.8. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS40545_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="IEZ14_RS40545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81970"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_218935203.1"
                     /sec_met_domain="AMP-binding (E-value: 4e-107, bitscore:
                     348.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGLGDCLRHWAAKRPEAPAVEFQGEAITYGELDRRSSALARTLI
                     DCGVVPGDRVALWLHKSIESVIAVHGVLKAGAAYVPIDPSAPFKRAGHIIAHCEVACVI
                     AQDDRVEWLRKDSSCRIVSVGLAADASVIGWEEALAAVPAKDARGPLPDLHGPAFILHT
                     SGSKGVPKGVVLSHGNARAFVEWAVAEFGLGPSDRVSSHAPLHFDLSVLDLFATCMAGG
                     CVVLVPESQVGLGGALNRFVVERRITVWYSVPGALTRMLAAKNSGLLAGSRLRVVLFAG
                     ETFPIARLRQLHSLIADADFYNLYGPTETNVCVFHRVRGSDVTEERRHPVPIGRACPYA
                     ATFIVDAAGRPVAHEPAASGELCVAGDSVMLGYWRDDDETTAKTVRIPRDGAEPLDAYR
                     TGDLVRLDDELNYVFCGREDDMVKVRGHRVEIGEIEAVLSAADNVREAACVAVDDGTGE
                     RVIEAYLVPEAPPLDLSAVRRHCLTEIPRYMVPERFHVRTAFPVTGTGKIDRKRLGETR
                     ADPR"
     aSDomain        12859..14109
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS40545_AMP-binding.1"
                     /evalue="1.10E-96"
                     /label="IEZ14_RS40545_AMP-binding.1"
                     /locus_tag="IEZ14_RS40545"
                     /protein_end="425"
                     /protein_start="8"
                     /score="315.8"
                     /specificity="substrate consensus: Pro"
                     /tool="antismash"
                     /translation="RHWAAKRPEAPAVEFQGEAITYGELDRRSSALARTLIDCGVVPGD
                     RVALWLHKSIESVIAVHGVLKAGAAYVPIDPSAPFKRAGHIIAHCEVACVIAQDDRVEW
                     LRKDSSCRIVSVGLAADASVIGWEEALAAVPAKDARGPLPDLHGPAFILHTSGSKGVPK
                     GVVLSHGNARAFVEWAVAEFGLGPSDRVSSHAPLHFDLSVLDLFATCMAGGCVVLVPES
                     QVGLGGALNRFVVERRITVWYSVPGALTRMLAAKNSGLLAGSRLRVVLFAGETFPIARL
                     RQLHSLIADADFYNLYGPTETNVCVFHRVRGSDVTEERRHPVPIGRACPYAATFIVDAA
                     GRPVAHEPAASGELCVAGDSVMLGYWRDDDETTAKTVRIPRDGAEPLDAYRTGDLVRLD
                     DELNYVFCGREDDMVKVR"
     CDS_motif       13045..13083
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40545_0001"
                     /evalue="3.80E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="IEZ14_RS40545"
                     /protein_end="83"
                     /protein_start="70"
                     /score="19.9"
                     /tool="antismash"
                     /translation="GVLKAGAAYVPID"
     CDS_motif       13306..13365
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40545_0002"
                     /evalue="1.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="IEZ14_RS40545"
                     /protein_end="177"
                     /protein_start="157"
                     /score="24.1"
                     /tool="antismash"
                     /translation="AFILHTSGSKGVPKGVVLSH"
     CDS_motif       13480..13515
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40545_0003"
                     /evalue="1.90E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="IEZ14_RS40545"
                     /protein_end="227"
                     /protein_start="215"
                     /score="-0.2"
                     /tool="antismash"
                     /translation="ATCMAGGCVVLV"
     CDS_motif       13906..13983
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40545_0004"
                     /evalue="4.10E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="IEZ14_RS40545"
                     /protein_end="383"
                     /protein_start="357"
                     /score="25.6"
                     /tool="antismash"
                     /translation="ASGELCVAGDSVMLGYWRDDDETTAK"
     CDS_motif       14074..14139
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40545_0005"
                     /evalue="2.50E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="IEZ14_RS40545"
                     /protein_end="435"
                     /protein_start="413"
                     /score="32.4"
                     /tool="antismash"
                     /translation="FCGREDDMVKVRGHRVEIGEIE"
     gene            14397..15194
                     /locus_tag="IEZ14_RS40550"
                     /old_locus_tag="GCM10010177_81980"
     CDS             14397..15194
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012958.5"
                     /locus_tag="IEZ14_RS40550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81980"
                     /product="alpha/beta hydrolase family protein"
                     /protein_id="WP_179835450.1"
                     /transl_table=11
                     /translation="MKVLTETWRSESIGREKSVNVLLPSRYSSAGRAFPVLYLLHGFGG
                     NRSTWLQCDDLSTVVDSAGLVVVLPESGRSWFINDARGRRYEDYLVEEVVGHVDDAFNT
                     VASRDGRGIGGFSMGGAAALYQALRHGEVFSVVCSNAGAFEAPLREGDPYGHLRDGQRL
                     AMPTTRDHERVWGPVGSEVRREYDPYRAVRDRDAKYPIDVNLDVGLDDYPRMIDMNRRM
                     REALAASSVPHRYRERPGGHDWEFVNAGLPDLFAFARSRLLSA"
     gene            15234..17057
                     /gene="asnB"
                     /locus_tag="IEZ14_RS40555"
                     /old_locus_tag="GCM10010177_81990"
     CDS             15234..17057
                     /EC_number="6.3.5.4"
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="asnB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017596043.1"
                     /locus_tag="IEZ14_RS40555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81990"
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="WP_179835449.1"
                     /sec_met_domain="GATase_7 (E-value: 1.2e-48, bitscore:
                     154.5, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 1.5e-91, bitscore:
                     298.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGITGWADWTRDLSQQGPVVTGMTRTQAPRGPDDEGTWLSRHAA
                     LGHRRLAVIDIEGGRQPMLREGRDGEPVVITFSGEIYNFHELRAQLRSAGWSFSTRSDT
                     EVLLTAYLQWGADLVTRLNGMYAFAIWDEHARQLLLVRDRLGIKPLYYARLGDGIIFGS
                     EPKALLAHPEMKAEVDLEGLAELTAVPRARTPGHAVYRGMRELKPGCLVVAGPSGCRES
                     RYWQVEARPHTEDFRTTTAEIRSLLTDIVRRQVVADVPVGTLLSGGIDSSAITALAARE
                     FEGELTSYSVSVPAPARPGSDLWRPSPDEPYARLVADRLGLKHSVVQVGTDSLVEGIDR
                     GLRARDLPGWGDLDISMYHLFRGVRGGCTVALSGESADEMFGGYTWQVDDRYVRHTSFP
                     WMYARRQPQFLLREEVRRAIRPEEYEADRYREALGEVPHLGGEDRTGRRQREVFYLGLT
                     RWLGALLDRKDRMSMAVGLEVRVPFADHRLAEYLFNVPADMKADGGTEKAVLRRACADL
                     LPEEIVNRPKSAYPASRDPGYVETLKNLVIETIDEPGAPLFDLMDRAKVRQAVTSDLDA
                     LPGPITARTSAIGLSYLLELNRWLTRVRVVT"
     gene            complement(17086..18717)
                     /locus_tag="IEZ14_RS40560"
                     /old_locus_tag="GCM10010177_82000"
     CDS             complement(17086..18717)
                     /NRPS_PKS="Domain: AMP-binding (23-438). E-value: 7.6e-80.
                     Score: 260.4. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS40560_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="IEZ14_RS40560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_82000"
                     /product="AMP-binding protein"
                     /protein_id="WP_179835448.1"
                     /sec_met_domain="AMP-binding (E-value: 3.7e-86, bitscore:
                     279.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMTSANYRDRGWWRDETFLDDLRRHVRDRPGKTAVVTRRQSDGR
                     THRLDYERLAAAADRCAGALVELGLRPGDVFAAQLTDRWELAAITLGCIRAGVVYCPLM
                     KTYRRRELDVMLRVTEARVLVTMEEDNGDRLGELGAELAAELPSLERVFVADGQGPEGT
                     EDFESFFFGTAWEERHGHLLDERELGPDDPYLVLFTSGTTSDPKGVLHSQNTLYAAIRG
                     EAETFGLDETLVMYTTALYTHYTGVVQGMLMPLALGGTMAFQDAKDPGDALDLMARQGV
                     TFFYCAPFYLLSLIKEQRSAPRALPALAWLVSGSAPIPPYFIGETESVFGLRLYSLWGM
                     TENGPVTIIRPDDPEDWAAHSDGSPISDMELRIDPVSDRTEGEGVLWVRGPTQCLGYYR
                     RDELYAADLDEGGWFNTGDLARPDGRGGIRITGRAKDMILRNANIAPVTDLESIIGRHP
                     GVRDVAVIGLPDEHEDETICAVVTPVSATAPVTLEELQSSLDEAGMTKAYWPRRLELLE
                     VLPTTATGKIRKEDLRRRYSRAERTR"
     aSDomain        complement(17404..18648)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS40560_AMP-binding.1"
                     /evalue="7.60E-80"
                     /label="IEZ14_RS40560_AMP-binding.1"
                     /locus_tag="IEZ14_RS40560"
                     /protein_end="438"
                     /protein_start="23"
                     /score="260.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RRHVRDRPGKTAVVTRRQSDGRTHRLDYERLAAAADRCAGALVEL
                     GLRPGDVFAAQLTDRWELAAITLGCIRAGVVYCPLMKTYRRRELDVMLRVTEARVLVTM
                     EEDNGDRLGELGAELAAELPSLERVFVADGQGPEGTEDFESFFFGTAWEERHGHLLDER
                     ELGPDDPYLVLFTSGTTSDPKGVLHSQNTLYAAIRGEAETFGLDETLVMYTTALYTHYT
                     GVVQGMLMPLALGGTMAFQDAKDPGDALDLMARQGVTFFYCAPFYLLSLIKEQRSAPRA
                     LPALAWLVSGSAPIPPYFIGETESVFGLRLYSLWGMTENGPVTIIRPDDPEDWAAHSDG
                     SPISDMELRIDPVSDRTEGEGVLWVRGPTQCLGYYRRDELYAADLDEGGWFNTGDLARP
                     DGRGGIRITGRAKDMI"
     CDS_motif       complement(18082..18132)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40560_0001"
                     /evalue="1.10E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="IEZ14_RS40560"
                     /protein_end="212"
                     /protein_start="195"
                     /score="18.2"
                     /tool="antismash"
                     /translation="VLFTSGTTSDPKGVLHS"
     gene            complement(18931..19173)
                     /locus_tag="IEZ14_RS40565"
                     /old_locus_tag="GCM10010177_82010"
     CDS             complement(18931..19173)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS40565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_82010"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_179835447.1"
                     /transl_table=11
                     /translation="MREADFAGDVHLVGGQQTIQAFRDIDALDELGVVVMPVLLGDGLR
                     LTLEKSATTPLQLAGSRTFPDGSAEHRYTLVRDRD"
     misc_feature    19294..19311
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.23"
                     /tool="antismash"
     misc_feature    complement(19296..19311)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.58"
                     /tool="antismash"
     gene            19546..19635
                     /gene="kdpF"
                     /locus_tag="IEZ14_RS42220"
     CDS             19546..19635
                     /EC_number="7.2.2.6"
                     /GO_component="GO:0031004 - potassium ion-transporting
                     ATPase complex [Evidence IEA]"
                     /GO_process="GO:0006813 - potassium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0043462 - regulation of ATP-dependent
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="kdpF"
                     /inference="COORDINATES: protein motif:HMM:TIGR02115.1"
                     /locus_tag="IEZ14_RS42220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="K(+)-transporting ATPase subunit F"
                     /protein_id="WP_229810772.1"
                     /transl_table=11
                     /translation="MTVENGIGLALAVVLVAFLVAALLFPERF"
     gene            19635..21302
                     /gene="kdpA"
                     /locus_tag="IEZ14_RS40575"
                     /old_locus_tag="GCM10010177_82020"
     CDS             19635..21302
                     /EC_number="7.2.2.6"
                     /GO_component="GO:0031004 - potassium ion-transporting
                     ATPase complex [Evidence IEA]"
                     /GO_function="GO:0008556 - P-type potassium transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006813 - potassium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="kdpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633321.1"
                     /locus_tag="IEZ14_RS40575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_82020"
                     /product="potassium-transporting ATPase subunit KdpA"
                     /protein_id="WP_179835445.1"
                     /transl_table=11
                     /translation="MSPTIAGVLFLGSLLLALALSCRPLGDYMHRVYSGTRHSRVERVL
                     YRLVGVDPDAEQRWGVYARSVLAFSVVGVLFLYGFQRVQNHLLLSLGFDPVKPDQAWNT
                     AVSFVTNTNWQSYSGESTMGHLVQMAGLAVQNFVSAAVGMAVAVALVRGFARRKSDHLG
                     NFWVDLTRGSLRILLPIAFVGAVVLVSGGLVQNFWDPAHHTVDTIAGGTQTLTGGPVAS
                     QEVIKELGTNGGGFYNANSSHPFENAVSWTNWLEIFLILVIPFALTRTFGRMVGQVRQG
                     YAIAAVMGVLALVSVSLTMIFQGMHHGTVPTAVGAATEGTETRFGVLDSAVFAAATTLT
                     STGAVDSFHDSYTSLGGMMTLFNMMLGEVAPGGVGAGLYGMLVLAVITVFVAGLMVGRT
                     PEYLGKRIGSREIKFAALYFLVTPALVLAGSAAAMATESGRAGLLNSGPHGLSEVLYAF
                     TSASNNNGSAFAGLTVNTVWYDTALGLCMAFGRFLPIIFVLALAGSLARQGHTPESDGT
                     LPTHRPQFVGLVAGVTVVLVALTFLPALALGPLAEGIH"
     gene            21302..>22800
                     /gene="kdpB"
                     /locus_tag="IEZ14_RS40580"
     CDS             21302..>22800
                     /EC_number="7.2.2.6"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0031004 - potassium ion-transporting
                     ATPase complex [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008556 - P-type potassium transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006813 - potassium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="kdpB"
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074345.1"
                     /locus_tag="IEZ14_RS40580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="potassium-transporting ATPase subunit KdpB"
                     /protein_id="WP_189269988.1"
                     /transl_table=11
                     /translation="MSTTQTARTPAQSPVPQPSGRVRGGLLDPRQMLRSLPDAIRKLDP
                     RTLWRNPVMLIVEIGAVWSTILAATDPTWFAWLVVVWLWLTVVFANLAEAVAEGRGKAQ
                     ADTLRRAKRDMTARRLVGWSPAAVDVREESVPAPRLAQGDIVVVEAGQIIPADGDVVDG
                     IASVDESAITGESAPVIRESGGDRSAVTGGTRVLSDRIVVQVTQKPGESFIDRMIALVE
                     GSSRQKTPNEIALNILLAALTIIFLLAAATLQPLAIYSKDANPGVPDSPALDAHGVTGI
                     VLVSLLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVDTLLLDKTGTI
                     TLGNRQAAEFLPLAGVPEEELADAAQLSSLADETPEGRSVVVLAKQRYGLRERTPGELS
                     HADWVAFTAQTRMSGVDLDEGAKRSLRKGAAGAVTDWVRRQGGTVPPMLGQIVDGISAS
                     GGTPLVVGESAGGGARVLGVIHLKDVVKQGMRERFAAMRAMG"
ORIGIN
        1 accaccgccg ccgccgaagg gatcagactc gtcgtggtcc tggtgcagaa ccacggctac
       61 gcctccatcg gcaacctgtc ggagtccgtc ggcgcccagc gcttcggcac ccgccaccgc
      121 ctgcgcaccc ccaccggcct ggacggcgac cccatccccc tcgacctcgc cgccaacgcc
      181 gccagcctcg gcgccgacgt catccgcgcc gacgacgccg acggattcag gaaggcgctc
      241 cgccaggcga tcgcgtcgcc ccgcacgacg gtcgtgcacg tggagaccga ccccctcgcc
      301 gcaggcccgg gcagcgaggc gtggtgggac gtcccggtcg ccgaggtctc cgaactggac
      361 gacacccggc gggcacgcgc ccactacgac gacagcaaga agactcagcg ccgttacctc
      421 tgaaaggaac ctgatgcgtt ctatccagca ctggatcggt ggtgtcccgg tgggcgggag
      481 cacctcggcc gccgtccacg acccggcgac cggcctgcag tcgggcgagg tcgtgctcgg
      541 gcggcgcgcc gaggtcgacc tggcggtggg ggccgcggcg cgggcgttcg agtcgtggtc
      601 cgaggtgtcg ctgagccggc gggcgcagat catgttcgcg ctgcgcgacc tgctggaacg
      661 gcacgaggac gagctggccc gcctggtcac cgccgagcac ggcaaggtcc tggacgacgc
      721 gcgcggagag gtcgtgcggg ggcgggaggt cgtcgagttc gcctgcggga tcgcgcaggt
      781 gctcaagggc gagtactccg accaggtgtc gtcgggggtg gacgcgttct cgttccggca
      841 gccgctcggc gtgtgcgcgg gcgtcgtccc gttcaacttc ccggtcatgg tcccgctgtg
      901 gatgcacccg atcgccatcg cgtgcggcaa cacgttcgtg ctgaagccga gcgagcgcgt
      961 gccgtcggcg tccaatctgg tcgccgagct gtacgcgcag gccgggctgc cggacggggt
     1021 gttcaacgtg ctgcacggcg accacgagac cgccgacgcg ctgatcacgc acccgggcgt
     1081 ggcggcggtg tcgttcgtcg ggtccacgcc cgtcgcgcgg cacgtccacg aggcggcgag
     1141 ctccgcgggg aagcgggtgc aggccctcgg cggcgcgaag aaccacgcgg tggtcctgcc
     1201 cgacgccgac ctcgacctgg ccgcggacca gatcacggcg gcggcgtacg gatcggcggg
     1261 ccagcgctgc atggcggtgt ccgtcgcggt cgccgtcggg gccgccgcgg acccgctgat
     1321 cgagcggctc gccgcccggg cccgcgcgat cagggtcggg ccgggcgacg acccggcgag
     1381 cgagatgggg ccggtgatca gtgaagcggc gcggcagcgc gtcaccggcc atgtcgagga
     1441 cgccgagcgg gccggcgcga agctcgtcgt ggacgggcgc ggcgcggccg gccccgggtt
     1501 cttcgtcggc ccctgcctgc tcgacggcgt cgccaccggc atggcggcct accaggagga
     1561 gatcttcggc ccggtcctgc tggtgctgcg cgccgagacg ctcgacgagg cgatcgcgct
     1621 gatcaacgcc aacccctacg gcaacgggac ggcgatcttc acctcgtccg gagaggcggc
     1681 gcggcggttc cagcgggccg tgcacgtcgg gatgatcggg gtgaacgtcc ccatcccggt
     1741 gccgatggcg ttctactcct tcggcggctg gaaggcgtcc ctgttcggtg acacccacgt
     1801 ccacggggcc gaaggggtgc gcttctacac gcgcgccaag gccgtcacgt cccggtggcc
     1861 cgcccccgtc gtggccgacg gggcatcctc aatggccttc cccacggccc gatgaggacc
     1921 cgcgcacggt ggtgagcgcc tcgtcgaggg acaggacgtc ggcgtacttg gcgcccaggt
     1981 ccagcaggtt cgcctcgtgc aggcggcggt cccggtcgcc gcaggcctcg tccaccacca
     2041 gcgggcggaa cccgtgctgc agcgcgtcgg tcgcggtggc gcggatgcag ccgctggtgg
     2101 tgagcccgca gaccagcacg gtgtcgatgc cggacgcggt cagggtggcc gccagggacg
     2161 tgccgtggaa cgcgctggcg tactgcttgg tgaccacggt ctcgccggca cgaggggccg
     2221 ccccctcggc gaagtcgccg agggggctcc cttcctcgaa tacgcggagc gcgggaatct
     2281 tgcggcggaa caggccgccg tccgcgccgc ccggctggta cttcacccgc gtgaacagca
     2341 cgggcagccc ggccgcccgg cccgcgtcga cgagggtcgc ggcggcggcc accgcttcct
     2401 cgaccggggc gcgcagcggc gacccgtcca ccaggtaggc gcggacgagg tccacggcca
     2461 gcaccgccgg cgaccggccg cagccgaggc cgcggccgaa tcccgaggcg cggtagccgg
     2521 cggcgaggtc gtcgctcacc ggcggtcccg cagcgcggcg gcggaccgga cgtcgaccgg
     2581 cgggcgcggc gcgggaaggc ccgtctcctc ctcgcagcgg gcgaggatct ccgccagcgg
     2641 cgggcccatg tcgaagaccg ggatctctgt ccgctcctcg gccatcctcg cccgcagcag
     2701 gtcggtggcc tcctcgtcga ggacgccctc ggcggtgcag acgaccccgt agccggcgcg
     2761 ggcgccgtcc gcggtgacca ggccgcgcag gacctccagt gcgaccagtt cggcgggacg
     2821 ggcgaggggg tcgccccatc cgccgccgcc ccaggtcacg aagtgcagga cgtccccggg
     2881 cccgaccacg acgtcgtgga tcttgctggg cagcacctcc cgggtgccgt ccgcccgttc
     2941 gatccacttg cggccccgct cgcccggacg tccgccgttc accccccacg ggtaggtgag
     3001 ccagcggtcg tcgtggatcg cgatcgtgcc gggctcctcg aagcagtacg cgacgtcgac
     3061 cccgttgccg ccccggtgca ggcccgcgcc gccggagtcg gcgatcgtct cccaccgctc
     3121 gacgcgcagc gggtagtacg actccaggta ctcgcagggg atgttgacga acgacggcca
     3181 cagcgagtgc ccgtccgggc cgtccccgac ggggcgtccc ggcacaccgc cgaacccgat
     3241 cgagtacagc tggaaccact cgccctcgcg cggccccgag ccgtagtggc ccgagtacat
     3301 gaagtgcggc gaggacgaga agccggccgc gttgaggatc tccgggttgg tctggccgag
     3361 cagcccgccg aacaggtcga acacccggcc gatgccgtgg ttgcgggcgt tcagcgcggc
     3421 cgggtggcgc ggcttccaga acgagtcctc cgggatcgtc acgtcgatca gcgggtagaa
     3481 gccgtcgttc cagaggatct gcgggtccgc gacggtgatc acgtagatcc cgaagaacat
     3541 ccggacgagg ttctcgttga tgaagtagtt gaccggcccg acggcctgcg gagccgcgtg
     3601 ggagaagtcc agatggatct tctcgccggt ccgggtgagt gagatcttca gttcgtacgg
     3661 gccgtacccg cagccgtcgt cgcagatgta gtcggcgaac tccagcgtcc ggccgtcctc
     3721 gaagagggtg gccagcagga ccttcatggc ctggtagttg cggtcgagca gggcgtccag
     3781 cgccgacagg taggtctcga cgccgaaccg ggcgcacagt tcggagaccc gccgggcggc
     3841 cgtggtgcac gcggcgacca ggccgttcag gtcggcccgg ttccagtcgg gcatgcgcac
     3901 ctggttgagg atgatgcgca gcgccggctc gttcagccgg ccgccctcgt acagcttgaa
     3961 cggcgggacg accacgccct cctcgtagat ggtgcgggcg tcggcgggca tcgagctggg
     4021 cgtcttgccg cccacgtccg acatgtgccc gaacatcgag gaccagccga ccagccggcc
     4081 ctcgtggaag atcggcacca ccagcagcca gtcgttggcg tggctgatcg ccgcgccgca
     4141 cgcgtacggg tcggacgtca tcaggatgtc gccctcgccg atcgtcccgt cgaagttctc
     4201 caggaagtcg ggcaccgaga gcccgaactg gccgacgacc atcttccccg acggaccggc
     4261 gatcagcggg aactcgtcgt gctgctcgcg gatgcccggg gacagcgcgg tgcggaacag
     4321 cacctcgtcc atctcgtggc gggcgttgcg cagcgcgttc tcgatgatgt ccagggtcac
     4381 cgggtcgacg tcgacgcggc cggccggcgc ggtcgcggtc tgcaggatct cggccatcag
     4441 ccctcctcgt tcagcggacg gatcagcagg ctgccgctcg ggtgcacggt cgcggcgtgc
     4501 ccggccagca cgagggtggt ggagtccatc tcgaccacca cggccggtcc ggccacgacg
     4561 tcccctgaga gcagccggga acggtcgtag acgcgggcgg acgtcgtggc gccgtccatc
     4621 cacacctcgg tctcgcggac gagcgcggcg gacgggtcgc ccgacccctc cggcagcacg
     4681 cgccaggcga cctccgggcg cggcccgctc accgtgaccc gcaggttgat cacctcgcgt
     4741 tcgttgccga gcaggaagga gaacagccgc tcgtgctcgg cgtcgaacgc ggcgccgagg
     4801 ccggccagca ggtcgccgtc gacagtggca cggtccagct cgaccgggat ctcgaagccc
     4861 tgcccgtggt agcgcaggtc gatctggtac gtcgcggtct ggctctcgcg cggcacgccc
     4921 tccgcctcca gccgcccggc ggcggcgtcg gccagttcgg cgagcgcggc gcgcagctcg
     4981 tcgtcgtcga gggtggagaa gcggcgcacc atcgtgcggg cgctctcgtc gcgcgggcag
     5041 gtggtcgcgt ccccgtaggc gcacaggacg cccggcgacg gcggcacgat caccggccag
     5101 gagccggtca gccggccgag cgcgttggcg tgcagcgggc ccgcgccgcc gaacgacatc
     5161 agcgcgaagt cgcgggggtc gtagccctgc cggacgctga tcaggcggag cgcgccgagc
     5221 atgttctcgt tgacgatgtc gatcacgccg gccgccgccg cctcgacgct cggcaggccc
     5281 atcgcgtcgg cgacggagcg catcgccttg cgggcggcct cggcgtccag ggcgatctcc
     5341 ccgccggcga gccgcgtcgg aaggtggccg agcacgacgt tggcgtcggt cacggtcggg
     5401 tcggtgccgc ccgccccgta ggcggccggg ccggggtcgg cgcccgccga ctgcgggccg
     5461 acccgcagcg ccctggtcag ctccgggacg tgcgcgatcg agccgccgcc cgcgccgacc
     5521 gtgcggacgt ccacgctggt ggcgcggacg gtgaggtcgc cgacggtggt ctcccggccg
     5581 atccgggggc gcccgccgag caccagcgcc acgtcggtgg acgtgccgcc catgtcgaag
     5641 gtgaggaagt cggggaaccc ggcctgctcg gcgaaccaga ccgcccccgt caccccgccg
     5701 gccgggccgg acagcagcag cgacaccggg tcctcggccg ccttggcggc cttggtcagc
     5761 ccgccgtcgc tgcgcagcac cgacagcggc gcgtcgatcc cgctgccgct cagcgaccgg
     5821 tccaggttgc ccacgtagcg ggacacctcg ggctgcacat agctgttcgc cacggtggtg
     5881 acggtgcgct cgtactcccg catctccggc aggacatggc tggacagcga caccggcacc
     5941 ccgggcagct cctcggcggc cagttcggcc acccgccgct cgtgcgcgtc gttcgcgtag
     6001 gagttgatca gcgagaccgt cagcgcctcg atgccggccc cgccgagccg ccgcagctcc
     6061 gcacgcgcgc ggtcctcgtc cagcggggcg acgaccgtgc cgtcggcggc gatccggcca
     6121 gggatctcca cggtgtgctc cagccgggcc agcggctcgg gcttcggcca gatgatccag
     6181 ccggcgaggc cgccggggac gaacgaccgg ccgatctgca ggacctgccg gaacccctcg
     6241 gtggtcacca gcccgacccg cgcgccccgg ccctggagga tcgcgttggt cgccacggtg
     6301 gtgccgtgca ggacgtgcgc cacctcgtgc atctcgatcc cggcgtcccg gcacaccttg
     6361 cggatgccgt tgagcacgcc ctccgactgg tcggccggag tggacgccgt cttggcgcgg
     6421 tggctgacgc cggtccgctc gtcgaccagc agcacgtcgg tgaacgtgcc gcccacgtcg
     6481 acgcccagtc gataacccat ctgctctccc ggtgctgtgc tcagatgacg ccgcgctccg
     6541 acagcgcggc gatctcgtct tctggtaggt ccaggaggcc gccgtagacc tcccggttgt
     6601 gctcgccgag cccggggccg ggccggcgga ccgcccccgg ggtctcgctg agcctgggga
     6661 acgcgttgtg catcgggagc tcgccgaagt ccgggtggac gaggcgcacg atcgcctcgc
     6721 gggcggcgaa gtggggatcg tcgaacatgt ccttggcggt gtagatgcgg ccggccggga
     6781 cgccgccggc gtgcagccgc tccagcaggt cctccgtctc gatccgggcc gaccaggccg
     6841 agatgatctc gtcgagctcg gccatgttcc ggccccggtc ggcgtgcccg gcgtaccggg
     6901 ggtcggcgct cagttcgggc ctgcccatcg tcctggcgag ccggccgaac acggtgtcct
     6961 ggttggcggc gatcaggatc atctcgcccg acgcggtcgg gtagacgttg ctgggcgaga
     7021 cgttgggcag cacggatccg gtccgctcgc gctggtaccc ggcgaccgcc cactcgggca
     7081 gcagcgactc catcatcgcc agcaccgcct cgtagatggc cgagtcgacg acctggccgc
     7141 gtccggtgac gttccggtgg tggacggcga cgagcgcgcc gatcgtggcg aacaccgccg
     7201 ccagcgagtc gcccagcgag atcccggcgc gggcgggcgc gccgccggga tcgccggtca
     7261 cgtagcggat gccgcccatc gcctcgccga tcgacccgta cccggcgcgg ggggcgtagg
     7321 ggccggtctg cccgaacccg gacacgcgca ccaggaccag gccgtggttc gtctcgcgga
     7381 gccggtcgaa gtccatgccc cagcgctcca gcgtgccggg ccggaagttc tcgaccacga
     7441 tgtcggcgcg ctcgatgatc cgccgggcga ggtcctggcc ctcgggggtg cgcaggtcgc
     7501 aggtcaccga cttcttgttg cgggcgacca ccggccacca cagggacttg ccgtgcggct
     7561 tctcccgccc ccactggcgc atcgggtcgc cggcgccggg cgactccagc ttgatcactt
     7621 ccgcgccgaa gtcgccgagc agctggccgc agaacggtcc ggcgagcagc tgccccatct
     7681 ccacgacgcg gaggtcggcg agcgggcccc tggtgtccgg cgcggcgccg tcgtgcgttg
     7741 acatctagcc ggtcctcgtt tccgtgtcgt cgttccggtt gctcgggtcg ttccacttgc
     7801 tcggatcgtc ccggtcgtcc ggggcgcggg cggcgcgcag gagcaccgcc ttcgcggcga
     7861 gcacgtgcgc ccgcatcacc gactcggccc acgtcccgtc gcgggcgcgc agcgcggcgg
     7921 ccaactcccg gtggtgcgcg gaactgcggg cgaggtcggc gggggagtag cggtggaagg
     7981 tccgcatcac gagcgggagc tgcaccaccg cgttgagcat ggacacgagc cggccgctgg
     8041 aggcggcggc gcggacgatg tcgtggaact cggcgttgaa ctcggcgacc cggtccaggt
     8101 cctggccggg gcccggttcg acggccgcct ccatcaggcg gcacagctcg tccatccggt
     8161 ccaggtccgc ggcggtcacg cgggtggcgg cgcgacccgc ggcggcgctc tccagcagca
     8221 tccgcaggtc gtagatctcc tccaggtcct ccggcgtcca gtccgggacc cgcgcgccgc
     8281 ggtgcggcag gacctccacc aggccctcga cctccagccg ccgcagcgcc tcccggacgg
     8341 gcgtccggct ggagccggtg gcctcggcca gctcggcctc gccgagtcgt gccccgggtg
     8401 ggtggacgcc ggccaggatg tcggcgcgca gccgtgtgta gacacggtcc acggcacgga
     8461 ccatccgaac ctccctcgat cgattgcatg caacataggc ggaacgtgag ccttgacaca
     8521 agagacttcc caggacaatc ctgcagatga ctctggattg catacaaagg atgctcatgg
     8581 tcgaactcat cgaggtggcg ccccgggacg ggctgcagaa cgagtccgcg gtcctcgcga
     8641 ccgccgacaa ggtgcggctc atcgagcgca gcgtcgaggc gggactgcgg cggatcgagg
     8701 ccgtcagctt cgtgaacccg aagcgggtcc cgcagatggc cgacgccgag gcggtgatgg
     8761 agcggctccc caggccggaa ggcgtcggct acgcggggct cgtcctcaac cggcgcgggc
     8821 tcgaccgcgc gctggccgcc ggcgtcgacg agatcaacgt cgtcgtggtg gccaccgacg
     8881 agttcagccg ccgcaaccag ggctgcacgg tcgaggaggg cgccgcggcc tgggccgcca
     8941 tcgccgcgga cgcccgcgcc gccggcgtcc gccgcaccgt cacgatcgcc gccgcattcg
     9001 gctgcccctt cgagggcgag gtccccgcga gccgcgtgct cgacctggtc cgtcgggtcg
     9061 ccgaaagcga acccgacgag atcgccgtgg ccgacacgat cggcgtcggc gtccccgccc
     9121 aggtccgcgc gctgctgacg ggcgccgccg ggatcgcccc cggcgtcccg ctgcgctgcc
     9181 atttccacaa cacgcgcaac accggctacg ccaacgccct caccgcgctc gactgcgggg
     9241 tgagcgcgct ggacgccagc gccggcggct tcggcggctg cccgttcgcg cccgccgcca
     9301 ccggcaacat cgctaccgag gatctgctgt acgccctgga ccgctcgggc gtcgacaccg
     9361 gcgtccggat gtccgcggtc gccgagacgg cggcctggct gggcgaacgc cttggcaagc
     9421 ccgtcccggc cctgctcggc cgcgccggcc cgtttccggc cgccccctga tcggcaccgc
     9481 gcggcacgcg ggcgtcacag cgattcgatg aggcgcaggg acgccttgat ctcctcgtcg
     9541 gtgggagcga cgtcgacggt ctctccggag aggtggctct cgtaggcgcc gaggtccagc
     9601 agcccatggc cgctgagacc gaccaggacg acccgctccc ggtcctcttc gcgcgctcgc
     9661 accgcctcgt cgatcgcggc ggcgacggcg tgggccgatt cgggggcggg aacgagcccc
     9721 tcggccttgg cgaacgcggc gccgctctcg aagacgcggc tctgggagta ggaggtcgcc
     9781 tccaccatgc cgtggtcgta catcgcgctg acgatcggag cggcgccgtg gtagcgcagc
     9841 cccccggcgt ggatgtggta ggccgtgaac gtgtgcccga gggtgtacat cttgaccgcg
     9901 ggagtcacac cggagtagtc ggtgtaatcc atcatgtagc tgcccctggt catcttgggg
     9961 cacgcgtcgg gctcgaccgc caggaaccgc gtcgcggtgt tctcggtcag cgccgcccgg
    10021 tagaagggga aggtcaggcc ggcgaagttg ctgcccgctc ccatggcgcc gatcacgaca
    10081 tcggggaact cgcctgccag cttcatctgc agcagcgcct cctcaccgat gaccgtctgg
    10141 tgcatcagga cgtggttctc tccgctgccg atcgagaagc gcgcctccct ccggccgttc
    10201 gcgtactcga tcgcctcggc gttcgcgatc ccgagggtgc ccggcgaccg cgggtcggcg
    10261 cgcagggcgg ccctgcccac ctccgtcctc gtgctgggac tcgggatgac ctcggcgccg
    10321 ttcaaccgca tcagggtgcc ccggtacggc ttctgctcgt agctggaccg caccatgaag
    10381 acggtgcacg ccatgccgta cgggtggcat gccatcgcga gggcggtgcc ccactggccg
    10441 gcgccggttc ccgtcaccat ctccctgacg ccggacctgc cgtagtagaa ggcctgtgcg
    10501 agcgcggtgt ttatcttgtg gctgccggac gggctcgtgc cttcgtactt gacgtagatg
    10561 tgcgccgggg tgtcgagggc gctctccaac ctggacgcgc ggaaaagggg cgtcgggcgc
    10621 cagcgctggt attcggaccg aacggggccg gggatctcga cgtagcgttc acggccgatg
    10681 ctctggcggt acatcgacaa cggcagttgt ggctgcagtg gcgccgcgtc gccgcttctc
    10741 ggcggagccg gtcgcgccgg gggcacctcg atcggaaggt ccgcgagtat gttgtaccag
    10801 tgcgtgggaa cccggtcccg gtccagttcg aaagcctcgc gcatgttacg cttttccgcc
    10861 ctccgcctcg atgattccgc tgatcatgtc gacgaggctt cccacgttcc tcagttccgc
    10921 gagcatgacg tcctcgtcgt cgatctcgat gtcgaactcc ttctcgatct ccacgagggt
    10981 gtgcagcagg ctcagcgagt ccattcccac gatcggcgag tagagcgaga ccttctcgtc
    11041 gagccgctcg ggagtgatgt ccaaatcgag aacgcggatc atgatgcttt tgatccgcgc
    11101 cgccaggtcc acgttgttgg cacgatccat ggcatgcacc tcgtctgggc gtcggcccgg
    11161 gaaaggtaaa ggcgagtcgg ctcggcggga atcgatattc gcggatcgag ggtgcccgct
    11221 ggggggaacg gcgcatcgtt taccggcgac ctggccgtcc gaacctcggt tctcgccgac
    11281 gaaccggtgg cgggccgtcc atggccggaa cgttttccgc ttcgattggt tgacggtccg
    11341 taccgtacga caggcgccca gggggcgcaa gaggtcgtac ggagcgcccc gcagagccca
    11401 tttggcagaa gttgggcttc tcaagatcgc ttcacggatg cacaatgaca gcgatcggtg
    11461 cggcgcggcc gggtttcccg tggccgcctg gcggaccgga ggggcgacgc ttgcgattcc
    11521 gcgcggtagt ggcaccgtca cgccaatgtg cagcccgtgc gtcgccgggt acacggccgt
    11581 gacgccgctg ctctaaagca ggcggtcatc cggcgattct cgatatggca tgacatcccg
    11641 cttgggggat tggagagcca tgcggttcga atgggacggt ggccaggacg ggctgtaccg
    11701 cgttttccgc gcgttcggcg aagaagcgct gagcaaggac gtgaccgagc gggacagggc
    11761 cggggtgttc ggccgcgacg attggtcgcg ctgcgccgaa cagggcgttc tcggactgat
    11821 cctgccgtcc gagtacgggg gatccggatg cggtcccctc gactacgtgc acgcgatgga
    11881 ggggctcggc cacggctgcc tcgacaacgg cctcatgatg gcgatcggcg cccacatcct
    11941 ggccgtcgag gtgccggtgt ggaagttcgg cgacgaggag cagcggcgca ggtacctgcc
    12001 cgagctcgcc gccggccgcc tcatcggggc caacgcgatg accgagccgg gaagcggatc
    12061 ggacgcgctg gcgctcgcca ccacggccga gcgcgacggc gactcctacc ttctgaccgg
    12121 acgcaagcgc tacgtcacga acgcgccggt cgccgatgtc ttcatcgtgt acgcgaccgt
    12181 cgacccggag ctcggattca ccggcgtcac agcctttctg gtggagcggg gcgatcccgg
    12241 cgtctcggtg aaagagcagg ccgagaagat gggccttcgc accgcccgct ggggagaggt
    12301 cgagctggac gcgtgccgga ttcccgcctc tcggcggctc ggtgccgaga ggcagggatc
    12361 cgccgtgttc gcgcggacga tggcatggga gcgggcgctt ctcctggcac cgtggctcgg
    12421 cgtcatgcgg cgcgagatcg aggaatgcac gcgcttctgc cggcggcgcc gccagttcgg
    12481 caagcacatc gggagctacc aatcggtctc caaccggatc gtcgacatgc ggatccgctg
    12541 ggagatctcc cgcatgctcg tgcgccgcgc cgcggcggaa ctcgacggcc cggaggcgac
    12601 catctttccc gaggtcggca agttgtacgc gagcgaggcg gcagcggaga tcttcaccag
    12661 cgcgatgcag gtgtacgggg cgctcggcta ttcctccgaa gggcgcgccg aacgcaatct
    12721 ccgggacgcc ctcggcatga cgatctcgtc gggcacgtcg gacatgcagc gagtgatcat
    12781 ctccgggaag ctcggcctcg cctggccgga caccggggga agcggggagg aaaggtgaac
    12841 ggtctcggcg actgcctgcg ccattgggcc gcaaagcgtc cggaggctcc ggcggtcgag
    12901 ttccagggcg aggcgatcac ctacggcgag ctggatcggc gcagctcggc actggcccgg
    12961 acgctgatcg actgcggagt cgtacccggt gacagggtcg ccttgtggct gcacaagtcg
    13021 atcgagtcgg tcatcgccgt tcacggagtg ctgaaggccg gtgcggcgta cgtgcccatc
    13081 gacccgagtg cgcccttcaa gagggccggc cacatcatcg cgcactgcga ggtcgcctgt
    13141 gtgatcgccc aggacgaccg ggtcgaatgg ctgcggaagg actcctcctg ccggatcgtg
    13201 tccgtcggcc tggcggcgga cgcgtccgtc atcggctggg aggaggcgct cgccgccgtc
    13261 ccggcgaaag acgcgcgcgg accgctcccc gatctccacg gcccggcctt catcctccat
    13321 acctcgggat cgaagggcgt ccccaagggc gttgtgctct cccatggcaa tgctcgcgcg
    13381 ttcgtggaat gggcggtcgc cgaattcggt ctgggcccct ccgaccgcgt ttccagccac
    13441 gcgcccctgc acttcgacct gtccgtgctg gatctgttcg cgacgtgcat ggcgggcggc
    13501 tgcgtggtgc tggtgccgga gagccaggtc gggctcgggg gcgccctcaa caggttcgtc
    13561 gtcgagcggc gtatcaccgt ctggtactcg gtccccggcg cgctgacccg gatgctcgcc
    13621 gcgaagaaca gcgggctgct ggccgggtcg cggctgcggg tcgtcctgtt cgccggtgag
    13681 acgtttccga tcgcccggct ccggcaactg cactcgctca tcgccgatgc ggacttctac
    13741 aacctctacg gtccgacgga gaccaacgtc tgcgtcttcc accgcgtccg cgggtcggac
    13801 gtcaccgaag agcgccggca ccccgtgccg atcggacgcg cctgcccgta cgcggcgacg
    13861 ttcatcgtcg acgcggccgg acgcccggtg gcgcacgagc cggcggcgtc cggggagctc
    13921 tgcgtcgccg gggactcggt gatgctcggc tactggcggg acgacgacga gacgacggcg
    13981 aagacggtgc ggattccccg ggacggcgcc gagccgctgg acgcgtaccg gaccggggat
    14041 ctggtccggc tcgacgacga gctgaactac gtgttctgcg gccgtgagga cgacatggtg
    14101 aaggtacgcg ggcaccgtgt cgagatcggt gagatcgagg cggtcctgtc ggccgcggac
    14161 aatgtccggg aggccgcgtg cgtcgcggtc gacgacggca ccggggaacg ggtcatcgag
    14221 gcgtacctgg tgcccgaggc gcccccgctc gatctctccg cggtgcgccg gcactgcctg
    14281 accgagatcc cgcgctacat ggttccggag cggttccatg tcaggaccgc gttcccggtc
    14341 accggcacag ggaagatcga ccggaagcgg ctgggggaga cccgggcgga tccgcgatga
    14401 aggtcctgac ggagacctgg cggagcgagt cgatcggccg ggagaagtcg gtgaacgtcc
    14461 ttctgccgtc caggtactcg tcggccggcc gagcttttcc ggtgctgtac ctccttcacg
    14521 gcttcggagg gaaccggagc acgtggctcc agtgcgacga tctttcgacc gttgtggatt
    14581 cggccgggct ggtcgtggtc ctccccgagt ccggacgctc gtggttcatc aacgacgcgc
    14641 gggggcggcg ctacgaggac tacctggtgg aggaggtcgt cggccacgtc gatgacgctt
    14701 tcaacaccgt ggcgtcccgg gacgggcgag gcatcggagg gttctccatg ggcggggcgg
    14761 cggccctcta ccaggcgctg cggcacggtg aggtgttctc ggtcgtgtgc agcaacgccg
    14821 gtgccttcga ggcccccctg cgcgaaggcg atccctacgg ccacctgcgg gacgggcaga
    14881 ggctggccat gccgaccacg agggaccacg agcgcgtctg ggggccggtc ggcagcgagg
    14941 tccggcgcga gtacgacccg taccgcgcgg tccgggaccg ggacgcgaag tacccgatcg
    15001 acgtgaatct cgacgtcggc ctggacgact atccccggat gatcgacatg aaccggcgaa
    15061 tgcgtgaggc ccttgcggcc agttccgttc cccaccggta ccgggaacgg cccggcgggc
    15121 acgattggga gttcgtcaac gccggccttc ccgatctctt cgcgttcgcg cggagccgtc
    15181 tcctttccgc ctgatctgcg cgcaccacca agaggacaac ggaaggagcg cacgtgtgcg
    15241 gcataaccgg atgggccgac tggacgcggg acctctccca gcagggcccc gtcgtgaccg
    15301 gcatgacgcg aacgcaggcc ccgcggggcc cggacgacga ggggacgtgg ctctcccgcc
    15361 acgccgcact gggccaccgg cggctcgccg tgatcgacat cgagggcggg cggcagccca
    15421 tgctgcgcga ggggcgcgac ggcgagccgg tcgtcatcac gttcagcggc gagatctaca
    15481 acttccacga gctccgtgcg cagctgcgtt cggccggctg gtcgttcagc acccgatcgg
    15541 acaccgaggt gctgctgacg gcctatctcc agtggggcgc ggatctcgtc acacggctca
    15601 acggaatgta cgcgttcgcc atctgggacg aacacgcgcg gcaactgctt ctggtgaggg
    15661 accggctcgg catcaagccg ctctactatg cccggctggg cgacggaatc attttcggct
    15721 cggagcccaa ggcgctgctg gcccatcccg agatgaaggc cgaagtggac ctggagggcc
    15781 tcgccgagtt gacggccgtc ccgcgcgcga ggacgcccgg ccacgccgtc taccgcggga
    15841 tgcgggagct caagccggga tgcctcgtcg tcgccggccc ctccggatgc cgcgagagcc
    15901 ggtactggca ggtggaggcc cggccccaca ccgaggactt ccgcacgacg acggccgaga
    15961 tccgctccct gctcaccgac atcgtcaggc gccaggtcgt ggcggacgtg ccggtcggca
    16021 cgctgctgtc cggagggatc gactccagcg cgatcacggc cctggccgcc cgcgagttcg
    16081 agggagagct gaccagctac tcggtgagcg tcccggcgcc cgcccggccg gggagcgacc
    16141 tgtggcggcc cagcccggac gagccgtacg cgcgcctggt ggccgaccgg ctcggcctca
    16201 agcattccgt ggtccaggtc ggcaccgaca gcctcgtcga ggggatcgac cgcggcctgc
    16261 gggcgcgcga ccttcccggc tggggcgatc tcgacatctc gatgtaccac ctgttccgcg
    16321 gggtccgggg aggctgcacg gtggcgctgt cgggggagtc cgccgacgag atgttcggcg
    16381 gctacacctg gcaggtcgac gacaggtacg tccggcacac gtcgtttccc tggatgtacg
    16441 cgcgccgcca gccgcagttc ctgctccgcg aggaggtgag gcgcgcgatc cggccggagg
    16501 agtacgaggc cgaccgctac cgggaggcgc ttggggaggt cccgcacctg ggcggcgagg
    16561 accgcaccgg acgcaggcag cgggaggtgt tctacctcgg tctgacccgc tggctgggcg
    16621 cgctgctgga ccgcaaggac cggatgagca tggccgtcgg cctcgaagtg cgggtcccct
    16681 tcgccgacca caggctcgcc gagtacctgt tcaacgtgcc cgcggacatg aaggccgacg
    16741 gggggacgga gaaggcggtg ctgcgccggg cgtgcgcgga cctgctgccg gaggagatcg
    16801 tcaacagacc caagagcgcc tacccggcca gccgggaccc cggctacgtc gagacgctga
    16861 agaacctggt catcgagacg atcgacgaac cgggagcccc gctcttcgac ctcatggacc
    16921 gtgcgaaggt ccgccaggcg gtcacctccg acctggacgc gctgcccggc ccgatcaccg
    16981 cccgtacctc cgcgatcggc ctgtcctacc tcctcgaact gaaccggtgg ctcacccggg
    17041 tccgcgtcgt gacgtgacgc cggacggccg cgggcgccgc agccgtcatc gtgtccgctc
    17101 cgctcgcgag tagcgccggc gcaggtcctc cttccggatc ttccccgtcg cggtcgtggg
    17161 caggacctcc aggagctcca gccgccgcgg ccagtacgcc ttggtcatcc cggcctcgtc
    17221 cagcgagctc tgcaactcct ccagggtgac cggggcggtc gcggagaccg gcgtcaccac
    17281 cgcgcagatc gtctcgtcct cgtgctcgtc gggaaggccg atgaccgcga cgtcgcgcac
    17341 gccggggtgc ctgccgatga tcgactccag gtcggtgacc ggcgcgatgt tcgcgttgcg
    17401 caggatcatg tccttggccc ggccggtgat ccggatgccg ccgcgaccgt ccggtcgggc
    17461 caggtcgccg gtgttgaacc atccgccctc atcgaggtcg gccgcgtaca gctcgtcccg
    17521 ccggtagtag ccgaggcact gcgtcggccc ccgcacccac agcacgccct cgccctcggt
    17581 gcggtccgac acggggtcga tccgcagctc catgtcggag atggggctcc cgtcgctgtg
    17641 ggcggcccag tcctcggggt cgtccggacg gatgatcgtc accggcccgt tctcggtcat
    17701 gccccacagc gagtacaacc ggagcccgaa gacgctctcg gtctcgccga tgaagtaggg
    17761 gggtatcggc gcggagccgc tgaccagcca cgccaacgcg ggcagggcgc gcggcgcgga
    17821 ccgctgttcc ttgatcaggc tcagcaggta gaagggcgcg cagtagaaga acgtaacccc
    17881 ctggcgggcc atgaggtcga gagcgtcacc ggggtccttg gcgtcctgga acgccatcgt
    17941 cccgcccagc gccagcggca tcagcatgcc ctgcacgaca ccggtgtagt gcgtgtagag
    18001 cgcggtcgtg tacatgacga gcgtctcgtc gaggccgaag gtctccgcct cgccgcgaat
    18061 ggcggcgtac agcgtgttct ggctgtgcag gacacccttg ggatcgctcg tcgtgcccga
    18121 ggtgaacagc accaggtacg ggtcgtcggg accgagctcc cgctcgtcga gcaggtggcc
    18181 gtgccgctcc tcccatgcgg tcccgaagaa gaaggactcg aagtcctcgg tgccttccgg
    18241 cccctggccg tccgcgacga acacgcgttc cagggacggc agctccgcgg ccagctcggc
    18301 gcccagttcg cccagccggt cgccgttgtc ctcctccatg gtgacgagga cccgcgcctc
    18361 ggtgacgcgc agcatgacgt cgagctcgcg gcgccggtag gtcttcatga gggggcagta
    18421 cacgaccccg gcccggatgc agccgagcgt gatcgcggcg agctcccacc ggtcggtgag
    18481 ctgagccgcg aacacgtctc cggggcgcag cccgagctcg accagggcgc cggcgcacct
    18541 gtcggcggcg gcggcgagcc gctcgtagtc gagccggtgc gtccgcccgt cggactggcg
    18601 ccgggtgacc accgccgtct tccccggcct gtcgcgcaca tgccgccgga ggtcgtcgag
    18661 aaacgtctcg tcccgccacc agccgcggtc gcggtagttc gcggaggtca tggccatgtc
    18721 tgcaccaccg tcacatcttc gggaaaggtg gacccgtccg cgcggaattg gagatcaaca
    18781 taacccgaat tccgctaccg tcaccaccct cggcgccatg cgttgattgc ggtgacgcct
    18841 ttctcggcga cacggcggga cggctcccga gacggccggc gcggcggccc gttcgacggg
    18901 ccaccgcggc ctcgcgctcc tgtcaccggg tcagtcgcgg tcgcggacca gggtgtaccg
    18961 gtgctcggcg gagccgtccg ggaaggtgcg ggagccggcg agctggaggg gggtggtggc
    19021 gctcttctcc agggtcagac ggaggccgtc gccgagcagg acgggcatga cgaccacgcc
    19081 gagttcgtcc agtgcgtcga tgtcgcggaa ggcctggatg gtctgctggc cgccgaccag
    19141 atgcacgtcg ccggcgaagt ccgcctcgcg catgaggcga agcagttcgg ccggaaaggg
    19201 cctgaagccg gcaggcgggt gcgggggagc agaggggccg gcggcaggtc gaggaagccg
    19261 gacggcgccc tcggcggacg cctgaatgcg gcggcgttaa agatgcgtta agcgcggcgt
    19321 cctgcgcgct aagaacgcgt caacggctcg gggagatgcc gggaaagtgc cgtttacttc
    19381 ctgatgcacc cccacagcgg gtgcgggtgc gacgagcacc cggcgctcca tggcggccgc
    19441 gcgccgccct ccaaggaacc gagagatgtc agatctggcg ttcatcctgc tcacggtggc
    19501 ggtcttcatc gtgttcgcac tggtcgtgaa ggcggtcgag cgactgtgac cgtagagaac
    19561 ggaatcggcc tggcgctggc cgtggtgctg gtcgccttcc tggtcgcggc ccttcttttc
    19621 ccggagcgtt tctagtgagt ccgacgatcg ccggggtcct tttcctcggc tctctcctgc
    19681 tcgccctcgc cctttcgtgc aggccattgg gcgactatat gcacagggtc tattccggga
    19741 cccggcattc gcgcgtggag cgcgtactct accggcttgt cggggtcgat cccgacgccg
    19801 agcagaggtg gggcgtctat gcgcgcagcg ttctggcctt ctcggtcgtc ggtgtcctgt
    19861 tcctgtacgg cttccagcgg gtgcagaacc acctccttct cagcctgggg ttcgacccgg
    19921 tcaagcccga ccaggcatgg aacaccgcgg tcagcttcgt gaccaacacc aactggcagt
    19981 cgtactcggg cgagtcgacg atgggccatc tggtgcagat ggccgggctg gcggtgcaga
    20041 acttcgtctc ggccgccgtg ggcatggccg tggccgtcgc gctggtgcgc gggttcgcgc
    20101 gccgcaagag cgatcacctc ggcaacttct gggtcgacct gaccagggga tcgctgcgga
    20161 tcctgctgcc gatcgccttc gtcggcgccg tcgtcctggt gtccggcgga ctggtgcaga
    20221 acttctggga cccggcacac cacacggtgg acacgatcgc cgggggcacc cagacgctga
    20281 cgggcggccc ggtggcgtcc caggaagtga tcaaggaact cgggacgaac ggcggcggct
    20341 tctacaacgc caactcctcg cacccgttcg agaacgcggt gtcgtggacg aactggctgg
    20401 agatcttcct gatcctggtc atcccgttcg cgctgacccg gaccttcggc cgcatggtgg
    20461 gccaggtgcg gcaggggtac gcgatcgcag cggtcatggg cgtcctcgcc ctggtgagcg
    20521 tctcgctcac aatgatcttc cagggcatgc accacggcac ggtgccgacc gcggtcggcg
    20581 cggcgacgga gggcaccgaa acgcgtttcg gggtgctcga ctccgcggtc ttcgccgcgg
    20641 cgaccacgct gacgtcgacc ggcgccgtgg actccttcca cgactcctac accagcctcg
    20701 gcggcatgat gacgctgttc aacatgatgc tcggcgaggt ggcgcccggc ggcgtgggcg
    20761 cgggcctgta cgggatgctg gtcctcgccg tgatcacggt gttcgtggcg gggctgatgg
    20821 tgggccgcac gcccgagtac ctgggcaagc ggatcggctc ccgggagatc aagttcgccg
    20881 cgctgtactt cctggtcacg cccgcgctcg tgctggccgg gagcgccgcg gcgatggcga
    20941 ccgagagcgg ccgcgcgggc ctgctgaact ccggaccgca cgggttgtcg gaggtcctgt
    21001 acgccttcac gtccgcgtcc aacaacaacg gttcggcgtt cgccggcctc accgtcaaca
    21061 cggtctggta cgacacggcg ctgggcctct gcatggcgtt cggccgtttc ctgccgatca
    21121 tcttcgtgct cgcgctggcc ggctcgctgg cccgccaggg gcacaccccc gaatcggacg
    21181 gcaccctgcc cacgcaccgg ccccagttcg tcgggctggt cgcgggcgtc accgtcgtcc
    21241 tcgtcgcgct cacgttcctg cccgcgctcg cgctcgggcc gctggcagaa ggaatccact
    21301 gatgtccacg acgcagaccg cgcggacgcc cgcgcagtca cccgttcccc aaccctcggg
    21361 ccgcgtccgg ggcggcctgc tcgacccgcg gcagatgctg cggtccctcc cggacgcgat
    21421 ccggaaactc gacccccgga cgctgtggcg gaacccggtg atgctgatcg tcgagatcgg
    21481 cgccgtgtgg tccacgattc tggcggccac cgatccgacc tggttcgcat ggctggtcgt
    21541 cgtctggctg tggctcacgg tggtcttcgc caacctggcc gaggcggtgg ccgagggccg
    21601 cggcaaggcc caggcggaca cgctccggcg ggccaagcgg gacatgacgg cccggcgcct
    21661 ggtcggctgg agtcccgcgg ccgtggacgt gcgggaggag tcggtccccg caccgcggct
    21721 cgcgcagggc gacatcgtgg tcgtcgaggc cgggcagatc atcccggcgg acggcgacgt
    21781 cgtggacggc atcgcgagtg tggacgagtc cgcgatcacg ggggagtcgg ccccggtgat
    21841 ccgggagtcc ggcggcgacc gcagcgcggt gaccggcggc accagggtgc tgtcggaccg
    21901 catcgtggtg caggtgacgc agaagcccgg cgagagcttc atcgaccgga tgatcgcgct
    21961 ggtggagggg tcgagccggc agaagacgcc gaacgagatc gcgctgaaca tcctgctcgc
    22021 cgcgctgacg atcatcttcc tgctcgccgc cgcgacgctg cagccgctgg cgatctactc
    22081 caaggacgcc aatcccggag tgccggactc gccggccctg gacgcccacg gggtcaccgg
    22141 gatcgtattg gtgtcgctgc tggtgtgcct gatcccgacg acgatcggcg cgctgctgtc
    22201 ggcgatcggg atcgcgggca tggaccgtct cgtccagcgg aacgtgctgg cgatgtcggg
    22261 acgcgcggtg gaggccgcgg gagacgtcga caccctgctg ctggacaaga cgggcaccat
    22321 caccctcggc aaccggcagg cggcggagtt cctcccgctc gccggggtgc cggaggagga
    22381 actggccgac gcggcgcagc tgtccagcct cgccgacgag acgcccgagg gccgctcggt
    22441 cgtcgtcctg gccaagcagc ggtacggact ccgtgagcgc acgcccgggg agctgtccca
    22501 cgccgactgg gtggcgttca ccgcccagac ccggatgtcg ggcgtcgacc tggacgaggg
    22561 cgcgaagcgg tcgctgcgca agggagcggc cggcgcggtc accgactggg tccgccggca
    22621 gggcggcacg gtgccgccga tgctcggcca gatcgtggac ggcatctccg cctccggcgg
    22681 gacaccgctc gtggtcggcg agtccgccgg cgggggagcg cgcgtcctcg gcgtgatcca
    22741 cctgaaggac gtggtcaagc aggggatgcg ggagcggttc gccgcgatgc gggcgatggg
//
