LOCUS       NZ_BMRD01000035        36506 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence35, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000035
VERSION     NZ_BMRD01000035.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 36506)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 36506
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000035.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..36506
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     gene            <1..374
                     /locus_tag="IEZ14_RS40205"
     source          1..36506
                     /culture_collection="JCM:3295"
                     /db_xref="taxon:46158"
                     /mol_type="genomic DNA"
                     /organism="Actinomadura citrea"
                     /strain="JCM 3295"
                     /submitter_seqid="sequence35"
                     /type_material="type strain of Actinomadura citrea"
     cand_cluster    1..36506
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..36506
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[15822:21480](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(15823..21480)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     CDS             <5..374
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=3
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024110.5"
                     /locus_tag="IEZ14_RS40205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_189269986.1"
                     /transl_table=11
                     /translation="PDGGPAGVVLALLFLQVFAFSLAWIGTFVGVSVRTPTAAQTLSWT
                     LLFVLVVASNVMVPQQTMPGWLEALIKVNPISVVTTAMRGLMDGTVTAGQMGWAFLACA
                     ILVAVFAPLTMYRYGRARR"
     misc_feature    complement(52..67)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.2"
                     /tool="antismash"
     gene            complement(381..1796)
                     /locus_tag="IEZ14_RS40210"
                     /old_locus_tag="GCM10010177_81300"
     CDS             complement(381..1796)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853090.1"
                     /locus_tag="IEZ14_RS40210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81300"
                     /product="NDP-hexose 2,3-dehydratase family protein"
                     /protein_id="WP_229810765.1"
                     /transl_table=11
                     /translation="MAGMAGVNAGSRLRAPSEEPELDRRLAASAEYRPRPAGDIVDWLA
                     ERRRRVPVQVTRIPFERMAGWSFAPDSGDLVHESGRFFTVGGIHARTDYGATPEWRQPI
                     IYQQDVAIVGILAKEIDGVLHFLMQAKIEPGNVNTVQLSPTVQSTSSNYLRTHRGARSR
                     FVEYFTEPGRARVLVDVLQSEQGAWFWAKRNRNVVMEVTDEVEPHDDFAWMTLGQILDL
                     LHHPNVVNMDSRTVLACLLSSAPYMGALPGDGAPAASGSALLSPVQVRSWLTERKSAYT
                     LTTRAVPLDSVDGWERDAEAIRRPDGRYFSVVGVEVHAGNREVSDWCQPLLAPSGTGLA
                     ALVVRRINGVRHLLVRADLRPGCRDTVELGPTVQCTPENYEDATGERRPRYLDLVLSRA
                     VRVQYDVVQSEEGGRFRQALTRHLVVEVGGGFPAQPPPDFCWLTVPQVMELARQSYQVN
                     IEARSLLLCLHAL"
     misc_feature    complement(1853..1869)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.57"
                     /tool="antismash"
     misc_feature    complement(1857..1875)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.25"
                     /tool="antismash"
     gene            1901..2698
                     /locus_tag="IEZ14_RS40215"
                     /old_locus_tag="GCM10010177_81310"
     CDS             1901..2698
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017611499.1"
                     /locus_tag="IEZ14_RS40215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81310"
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_179834695.1"
                     /transl_table=11
                     /translation="MSATERDVAFGPEHAEVYELTYRHRGKDWGEEAAEVTRRIREHRP
                     RARSLLDVACGTGAHLEAFRSGFDHVEGLEISRSMRERAVRRLPGVTVHDGDMRAFALG
                     RAFDAVTCLYTAIAYLPSVAAMRAAVGAMARHLVPGGVLVIEPWWPPERFIEGFVGADL
                     VRDGDTVVARVSHSIRRDRAAHMDVRWLVGRPTGIREFRTVETFTMFTADEFLAAFRDS
                     GCDVEHEEAGLNGYGLFVGVRRGRTEAEPRPRRTGATRPSAGR"
     gene            complement(2673..3446)
                     /locus_tag="IEZ14_RS40220"
                     /old_locus_tag="GCM10010177_81320"
     CDS             complement(2673..3446)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024967.5"
                     /locus_tag="IEZ14_RS40220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81320"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_179834694.1"
                     /transl_table=11
                     /translation="MTPPNHRDPRSLARESDQERDVRERLTRLLRDTPIPPEYLIDNLA
                     LYLRRQQLTDLLCMDALYRMILDVPGVIMEFGVLHGRHLATLTALRGCHEPYTSVRRVI
                     GFDTFTGFPDIADVDRAGPNAVAGRFAVSEGYPDHLREVLDAHESGEPFAHVRRTAVVQ
                     GDVRETLPRYLADNPETVIALAYFDLDIYAPTRAALEAIRPYLTKGSVLAFDEIAYSKW
                     PGETAALREAVGLDVVTLRTLPGREPPITYLRWGE"
     gene            complement(3489..4490)
                     /locus_tag="IEZ14_RS40225"
                     /old_locus_tag="GCM10010177_81330"
     CDS             complement(3489..4490)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133509.1"
                     /locus_tag="IEZ14_RS40225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81330"
                     /product="aldo/keto reductase"
                     /protein_id="WP_179834693.1"
                     /transl_table=11
                     /translation="MPHPGEFRASLGSTDLRISRLGLGTVNFGGRVDGADAHRLMDHAL
                     ASGINLVDTADIYGWRVYKGHTEEVIGDWLGARPGRRDEVVVATKVGGPMSDDPGDRGL
                     SARHIVAACEASLRRLNTDRIDLYQMHQVDRSVPWDEIWLAMELLIGQGKIRHVGSSNF
                     AGWDIALAQETAARRRVPGLASEQCVYNLVTRHAELEVIPAATALGLGVLVWSPLHGGL
                     LGGVLRKKAEGTAVKSAQGRAVDALKEHEAAIADYERFCADIGRDPAEVGLAWTLSRPG
                     VTGVLVGPRTPDHVDGAVRALDKPLTEEETDRLEALFPPVGRGGPAPAAWMS"
     misc_feature    complement(4524..4537)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.16"
                     /tool="antismash"
     misc_feature    complement(4587..4598)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.03"
                     /tool="antismash"
     gene            4988..6325
                     /locus_tag="IEZ14_RS40230"
                     /old_locus_tag="GCM10010177_81350"
     CDS             4988..6325
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013884.5"
                     /locus_tag="IEZ14_RS40230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81350"
                     /product="acyltransferase"
                     /protein_id="WP_179834692.1"
                     /transl_table=11
                     /translation="MVTKASGGDAVGAAAPDPASDRPRKFIPELEGLRGAVVLLVVLGH
                     TGVATSVQGWSYMHSTGNGVWAIMLNRVAVAFPIWFVMTGYLLYRAFALYTLTGERKPN
                     AKRYFWRRALRILPAYWVLTITALLVLNRDTVHGVWEWIRPLLLLQIWEHGAIPMGMMH
                     TWSNANDFLFYLAMPVFAWLLHRYARRAESPEARVRRLLVPLAFPVFIGFGFFTWLHFP
                     QFRDDPMKLWPTQYFWPMSYMGWLSVGMMLAVLSAAAETRPDAVPRVYRLIGRHPGKLW
                     LGALLIFVLACLSPLADYRLVDYVAAPAAAADYWLFLAFSVAVFAPLTVPGVRFKLAGL
                     LLDNSLLRFFGRISYSVYLWHIFVYAQFVGPLFAPEVGGYWEVLGVELALCVMVGYASY
                     IVVEKPFHMLRPRLGKAPVELSVAVSTPAEAHATAGAVRTPRDAQA"
     gene            6416..7429
                     /gene="rfbB"
                     /locus_tag="IEZ14_RS40235"
                     /old_locus_tag="GCM10010177_81360"
     CDS             6416..7429
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009225 - nucleotide-sugar metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-183). E-value: 8.1e-18.
                     Score: 56.4. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS40235_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621686.1"
                     /locus_tag="IEZ14_RS40235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81360"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_179834691.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 5.4e-22, bitscore:
                     69.1, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.4e-18,
                     bitscore: 57.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.9e-18, bitscore:
                     56.4, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLLVTGGAGFIGSEFVRATLRGELPGTAGAYVTVLDALTYSGNL
                     QNLAPVAGHPRYRFVHGDTCDPDAVDAAVAGQDAIVHLAAESHVDRSIDTATPFVRTNV
                     LGTQNMLEAAQRHGVGRFVHVSTDEVYGSIAQGAWAEDAPLLPNGPYASAKAGSDLLAL
                     AWHRTRGLEVMVTRCTNNYGHYQFPEKVIPLFVTNLLDGRRVPLYGDGRHRRGWLHVSD
                     HCRALDLVLRSGRPGEVYHIGGGKELSNEDLTDLLLEACGAGWEAVDHVPDRQGHDRRY
                     ALDTTKIEERLGFVPRVRFEDGLEATVEWYRANRAWWEPLKAGLRELPGPALRSPR"
     aSDomain        6428..6964
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS40235_NAD_binding_4.1"
                     /evalue="8.10E-18"
                     /label="IEZ14_RS40235_NAD_binding_4.1"
                     /locus_tag="IEZ14_RS40235"
                     /protein_end="183"
                     /protein_start="4"
                     /score="56.4"
                     /tool="antismash"
                     /translation="VTGGAGFIGSEFVRATLRGELPGTAGAYVTVLDALTYSGNLQNLA
                     PVAGHPRYRFVHGDTCDPDAVDAAVAGQDAIVHLAAESHVDRSIDTATPFVRTNVLGTQ
                     NMLEAAQRHGVGRFVHVSTDEVYGSIAQGAWAEDAPLLPNGPYASAKAGSDLLALAWHR
                     TRGLEVMVTRCTNNYG"
     gene            complement(7413..8768)
                     /locus_tag="IEZ14_RS40240"
                     /old_locus_tag="GCM10010177_81370"
     CDS             complement(7413..8768)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547545.1"
                     /locus_tag="IEZ14_RS40240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81370"
                     /product="metallopeptidase TldD-related protein"
                     /protein_id="WP_229810766.1"
                     /transl_table=11
                     /translation="MAIVDEAATAHARWAGNALTSSGLTADTRLTVIAVTPGAHGTAAG
                     VVSHRGAVDEEAVRAVVAAAERAARTATPAADARPLLTGDVVPSSADWAEPAPTASAGV
                     LARFAASLAATFERARGERRLLYGYAEQRQHATWLASSTGLRLRHVQTSGVVDLTAKTG
                     DGAASTWSGTGAADLGEIDPLPLYEGLGERLDRGRRRVELPAGRYEVLLSPSCVADLML
                     RLYRAAGAKDAVDARTVFGGPDGGTRIGERLTGAPLTLRSDPHEPGLRCAPFVAARGSA
                     DVAQVFADTVSVFDNGLPLSPAEWIHDGVLTRLVQTRHSADLTGLPVTPQVGNLVLEGP
                     GEGRSLAELVATTRRGLLVTSLWYVRDVDPRTLLLTGLTRDGVYLVEDGEVVGETNNFR
                     FNESPVDLLGRVTEIGRTERTLPRERDDSTPRTAMPALRVGDYTMSAVSEAI"
     gene            complement(8898..10406)
                     /locus_tag="IEZ14_RS40245"
                     /old_locus_tag="GCM10010177_81380"
     CDS             complement(8898..10406)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291802.1"
                     /locus_tag="IEZ14_RS40245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81380"
                     /product="TldD/PmbA family protein"
                     /protein_id="WP_179834690.1"
                     /transl_table=11
                     /translation="MRRGVDASFSALPLDSLADAALGRAAGLGAGHASFRLDRVRTARL
                     LLRDGVLGGGQDATDTGLAVRLWHGGVPGFAAAPELTARAAAGAAEQAVAVARACSAIG
                     GGSGEPVGEPVHHGATWVSSYRVDPFEVPEEERIALMADWSRRLLAAPEVEHVLAFLTV
                     VRENKFYADLAGTVTTQQRVRVHPLFFVQGADPRGGGTATLRTLGPPTARGWEYLAGDG
                     WDWERELSELPAHLAAKLRARPVRPGRYDLVIDPSNLWLTVHESVGHTTEMDRALGHEA
                     SSTGTTFLTPEGLGSHRYGSPLMNVTADRTAEHGLATVGFDDEGVAAQSWSLVRDGVLT
                     GFQHDRRTAGLAGLGRSNGCSFAESAMHVPLPRMPNVGLRPAPGGPSTDDLIAGIEDGI
                     YLVGSDSWSIDMRRQNFQMTAQRCHRIRNGRLEGQLSGVAYQASTTEFWSALTALGGED
                     TYRLFGADLCGKGQPMQVAAAGHGCPAAVFRGIKVIDTGADGLP"
     misc_feature    complement(10441..10450)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     misc_feature    10535..10548
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.79"
                     /tool="antismash"
     misc_feature    10537..10546
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.37"
                     /tool="antismash"
     misc_feature    10538..10551
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.8"
                     /tool="antismash"
     misc_feature    complement(10547..10562)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.19"
                     /tool="antismash"
     gene            10634..12223
                     /locus_tag="IEZ14_RS40250"
                     /old_locus_tag="GCM10010177_81390"
     CDS             10634..12223
                     /EC_number="2.8.3.-"
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013323.5"
                     /locus_tag="IEZ14_RS40250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81390"
                     /product="CoA-transferase"
                     /protein_id="WP_179834689.1"
                     /transl_table=11
                     /translation="MDDVAAAAVGGKVCDAATAAALIEDGQSVASTGVIGWITPDAVLR
                     AIGERFERLGSPRDLTFFFPCATGDAMDIGGMDGVAREGLMRRIVAGSYINPRHPRTGA
                     RPALTELIRDDLVEAYSWPIGAAMHWLREVARRSPGYLTRIGLGTFADPRHGGGRLTGR
                     AKDDLVEVVELRGEELLLYPTWPLDVGIIRASSSDAHGNLSFEDLPLTSAALALALAVK
                     ASGGTVIAQVSRIVPRGSRPAREVQVPGVLVDRVVVAAGELIGTEVRNDPGYLRPVPHP
                     VGRLPRLRPGPGKVIARRVAREIRPGETTILGFGAASSAILAMAEDGAFRDDRLDDYTF
                     TTEHGSFGGVVMGGWQFSANYSPEALVDGTYQFDFIDGGGCALAALSFAQLDAAGNVNV
                     SRFAGTSPGGGGFVDIAHNAQRIVLGGTLTTQGLDVSCEGGRLDILREGEIQKLVPEAD
                     HVTYAVRAGLERGQRALVVTERAVFEMTAEGLVLTEVAPGVDVRRDVLGQIGFPVRPAA
                     GVTTMAADLFRP"
     gene            12243..13325
                     /locus_tag="IEZ14_RS40255"
                     /old_locus_tag="GCM10010177_81400"
     CDS             12243..13325
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893394.1"
                     /locus_tag="IEZ14_RS40255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81400"
                     /product="methyltransferase"
                     /protein_id="WP_229810767.1"
                     /transl_table=11
                     /translation="MNRMVKPDEPHGRRSGGPAPARHDGGLVSAAADEAVPALWAMAQL
                     ATPMAVRVAATLRIADHIASGLRTVPELAEATGAAPDGLARLMRYLAVRGVLSLDDSGR
                     YGLTALGEPLRGDHPAGLRACLDIEEGGRAELCYVELLHSVRTGEPAYPRRFGLSFWDD
                     LAAEPRHEAAFRAMLRPGGRDRARRIASAYDWASLGRVVDVGGGDGTLLVALLTAHPGL
                     RAVLVERPPATDAARKALAAAGVADRAEVETGDMFGPLPPGAGGYVLSLVVHNWGDDPA
                     RAILARCAEAAGTGGSVFVVENVGPGGGPTGLDLRMLAYCGGKVRSLPELSALADEAGL
                     RVASVHPAGAVSIVELHPGR"
     misc_feature    12244..12258
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.7"
                     /tool="antismash"
     misc_feature    12244..12259
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.64"
                     /tool="antismash"
     gene            13408..14631
                     /locus_tag="IEZ14_RS40260"
                     /old_locus_tag="GCM10010177_81410"
     CDS             13408..14631
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893418.1"
                     /locus_tag="IEZ14_RS40260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81410"
                     /product="cytochrome P450"
                     /protein_id="WP_179834688.1"
                     /sec_met_domain="p450 (E-value: 1.9e-22, bitscore: 70.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATGTMQPREALAALVGEGLRDPYPLYEEIRAHGDLVKIKPGVMA
                     AVGYDECDRVLRDPRLRVQDGESFDLFYPEWRAHSSLRAYTDSMLYSNPPAHTRLRRLL
                     RGEFTPRRVAGYETAIEQITDRLLDSLAEAGAGGTAVDFIAEFASRLPIAVISGLLGVP
                     ERDQAWFRAIAADVTTALEGITNASRLAPADTAMDDLAVYFDELIERRRRCPEADLVSS
                     LVRVHDDGGGLGRDELVGNMMLLLTAGFETTNFFMAHALLLSFEHPGLADRLRAEPGFA
                     SAYAEEVLRFEPPVQATSRWAGADVELLGTTIPAGTKVVAILAAGNRDPRRYRRPDRFD
                     PDRPYTAPLTFGAGGHFCLGAPLSRLEARIALPRLLRRFPRIRLAGEPARRDSWVGRGI
                     DHFPIAID"
     gene            complement(14670..15356)
                     /locus_tag="IEZ14_RS40265"
                     /old_locus_tag="GCM10010177_81420"
     CDS             complement(14670..15356)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015747.5"
                     /locus_tag="IEZ14_RS40265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81420"
                     /product="NADPH-dependent F420 reductase"
                     /protein_id="WP_179834687.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 9.9e-09, bitscore:
                     25.7, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFSESGAVPEARAPVIGIVGCGRMGTALAETFAAQRRPLLLASR
                     GGGSASGLAERLPGARAGSLERVAREADIVALASPLAAIHTEIAPRIRAHVVGKPVIDM
                     SNPGGHDLLGHGSAAELIACLLPGGAVVKAFNCLSARQLAGAAHNGVTLTVPIAGDHPR
                     AKEAVRSIVESGGLEVADAGDLPGSRWIEALAQLLMRLEKQPGLGDAVGFRLLRLTACE
                     AAWTRP"
     misc_feature    complement(15237..15239)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15353..15826)
                     /locus_tag="IEZ14_RS40270"
                     /old_locus_tag="GCM10010177_81430"
     CDS             complement(15353..15826)
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017588554.1"
                     /locus_tag="IEZ14_RS40270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81430"
                     /product="thioesterase family protein"
                     /protein_id="WP_179834686.1"
                     /sec_met_domain="4HBT_2 (E-value: 7.2e-15, bitscore: 46.5,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAYFEYRHLVTFADTNLVGNVYFTNYLSWQGACRERFLAEKAPK
                     TVARLNDDLALVTSSCSCEFFSELYALDTVSVRMSLVAIDFHQITMGFEYYRTTDGPAR
                     LVARGEQTVSCTVRVEEGGLTPVEVPDELRTALDAYAPDPHGARRPRSETPPR"
     gene            complement(15823..21480)
                     /locus_tag="IEZ14_RS40275"
                     /old_locus_tag="GCM10010177_81440"
     CDS             complement(15823..21480)
                     /NRPS_PKS="Domain: PKS_KS(Enediyne-KS) (7-463). E-value:
                     8.4e-96. Score: 313.4. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS40275_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (617-843). E-value: 9.1e-57.
                     Score: 184.6. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS40275_PKS_AT.1"
                     /NRPS_PKS="Domain: PP-binding (944-1012). E-value: 4.7e-07.
                     Score: 22.0. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS40275_PP-binding.1"
                     /NRPS_PKS="Domain: PKS_KR (1212-1392). E-value: 1.2e-30.
                     Score: 98.7. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS40275_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_DH (1455-1590). E-value: 7.7e-17.
                     Score: 54.1. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS40275_PKS_DH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     ene_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012337.5"
                     /locus_tag="IEZ14_RS40275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81440"
                     /product="type I polyketide synthase"
                     /protein_id="WP_179834685.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 2e-49, bitscore:
                     159.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 2.3e-233, bitscore:
                     765.6, seeds: 19, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 4.4e-57, bitscore: 184.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1e-06, bitscore:
                     20.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVENDAIAVVGLGCRHPDASTPEQLWETVLARRRAFRPLPRERL
                     DLGDYGDPAGGPDTTDLRYAAVLDGWTFDRSRYRVPGPAYRVTDLAHWLALDVAGDTLT
                     AAGFPGGRGLDRRRAGVILGNTLTGEFSRAALMRLRWPYVRRNLVSALAARGWGTTELD
                     GLLREVEESYKEPFAEPNDESLVGGLANAIAGRVCNHFDFRGAGYTVDGACSSSLLAVI
                     TACTYLRDGDLDFALAGGVDLSLDPFELVGFSRLGALADSAMRVYDARPTGFLPGEGCS
                     MVALMRAGDAVAAGQRPIALIRGWGMSSDGNGGLTRPDVSGQRLALERAYARAGFGPET
                     VALFEGHGTGTEVGDRTELHALSEIHDGRRRPRPAALGSIKANIGHTKAAAGAAGLIKA
                     ALALQRQVIPPTTGCDEPHPLLRDPGAPLRIVREAEPWPDAPLRAAVSAMGFGGINTHV
                     VLEAASVRRTTARLAARDRRAAREPLDCEVFALSADTVADLTALLERVAVRARTMSLAE
                     HADLAAGLGERAHGDAPVRAAVVARDPAELSARAERAGELLAGLGEQGFAARPGIYVGR
                     GAPARVGLLFPGQGAPVRERAGALGVVLPEAGEHFEDGLAADPIDTAVAQPAVFRASTA
                     ALRWLDRLGVTADAAVGHSLGEITALHWAGALSRQDALHLVTRRGRIMADTSQAGTGMA
                     SLAAPAGTVTELIDDADLVIAADNGAVQVVAGPLTEVDRVVKRARAKGITAGRLRVSHA
                     FHSPAVAAAEPVLARHLADLAVAALPGRVYSTVTGRELTAADDIRTLLARQLTAPVRFR
                     QALELLAADCDLLVEAGPGHTLTAMAQSITDVPVRTLDAGAGSAAALGDATAALFAVGA
                     VSDLTALFAERFHRPFDLWREPEFLANPCESAPTDGLDRRFGRSAAVAAGPVAADTAAP
                     AAEAPPGADSDVPSVVRGLIADALELPPDVIGDGDRLLGDLHLNSLRVVQLAAEAAERT
                     RRAVPAAPPLFAEATVGSFAQAIEELPAAEGEAGSQGPPEGVRDWHRVLVEYARPVELD
                     AEPGSRVWHVFGDGRLRALVEPRLTALTEGDERADSSGDPRPAVVAFLPENPDDGAIDA
                     LLEAAHLAVDTGAPFTVVDSGDTASGFVGTIAAEYPSLPVRWVRALAAAPADAVGALLT
                     ASWEGHAEIVVDEEGRTRAPAYRAAGSGAPAGPVPDAAGPPLSAGEVLVVTGGGKGIGF
                     TSAYFLARRWGVRLGLIGRSGADADAELRANLSRLGEAGIDFCYEAADVTDPESLHHGV
                     AAIVDRLGPVRGVIHASGLNRPARFSEIGAAYAEHAAPKHHGLRALLDAVDAEGLRLLL
                     TFGSVIGRFGLAGEAHYALANGRMRELVRTLARDLPGCRVANLDWTVWSGVGMGERLKV
                     LDDLARAGVAPVPPDRGTELLAQAAEARPPSHSMVISGRLPQLGQAGEAALDGHRFLRR
                     VRAWTPGVELVAEAELSLPGDPYLDDHRIDGVAVLPAVCVLEAMAQAAAALTGRPVAGV
                     VDSRFDRPVVVPEHGTRTVRICALVREDGDVDVAVRSDETGFAVDHFTGTVTPADAEPP
                     ENPAVTARVPAHTGDDMYGPLFFHGRRFRRLRRYAQLEATACTAVLDGDRPWRFGEGLP
                     ADLLFGDPARNDASIHVLQGCVPHRRLLPVGCARFAVHQGGAEGGELTLAAVEREHSGA
                     DHTYDVVVRDGSGRPVVSWTGLRLRDVGPLPVTTLHPVLVGPYLQRTLTALLPKRDVRL
                     VVEAAGPGHDLNAGRRANGRPWDVLVEGEPVACARTSDPAPEPPTHWTGLADRLGRLVG
                     EPERHIRTRLHTVGACLSGPPGPPGLAVQGVYENGWVVLQAGGADIVSVVLSVEGEAGP
                     MAMAIPVKGAS"
     aSDomain        complement(16711..17115)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS40275_PKS_DH.1"
                     /evalue="7.70E-17"
                     /label="IEZ14_RS40275_PKS_DH.1"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="1590"
                     /protein_start="1455"
                     /score="54.1"
                     /tool="antismash"
                     /translation="HRFLRRVRAWTPGVELVAEAELSLPGDPYLDDHRIDGVAVLPAVC
                     VLEAMAQAAAALTGRPVAGVVDSRFDRPVVVPEHGTRTVRICALVREDGDVDVAVRSDE
                     TGFAVDHFTGTVTPADAEPPENPAVTARVPA"
     aSModule        complement(16711..17844)
                     /domains="nrpspksdomains_IEZ14_RS40275_PKS_KR.1"
                     /domains="nrpspksdomains_IEZ14_RS40275_PKS_DH.1"
                     /incomplete
                     /locus_tags="IEZ14_RS40275"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(16954..17031)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40275_0006"
                     /evalue="3.70E-07"
                     /label="PKSI-DH_m2"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="1509"
                     /protein_start="1483"
                     /score="22.7"
                     /tool="antismash"
                     /translation="YLDDHRIDGVAVLPAVCVLEAMAQAA"
     aSDomain        complement(17305..17844)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS40275_PKS_KR.1"
                     /evalue="1.20E-30"
                     /label="IEZ14_RS40275_PKS_KR.1"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="1392"
                     /protein_start="1212"
                     /score="98.7"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="VLVVTGGGKGIGFTSAYFLARRWGVRLGLIGRSGADADAELRANL
                     SRLGEAGIDFCYEAADVTDPESLHHGVAAIVDRLGPVRGVIHASGLNRPARFSEIGAAY
                     AEHAAPKHHGLRALLDAVDAEGLRLLLTFGSVIGRFGLAGEAHYALANGRMRELVRTLA
                     RDLPGCRVANLDWTVWS"
     CDS_motif       complement(17374..17463)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40275_0005"
                     /evalue="7.10E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="1369"
                     /protein_start="1339"
                     /score="15.3"
                     /tool="antismash"
                     /translation="RLLLTFGSVIGRFGLAGEAHYALANGRMRE"
     CDS_motif       complement(17746..17838)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40275_0004"
                     /evalue="4.50E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="1245"
                     /protein_start="1214"
                     /score="9.7"
                     /tool="antismash"
                     /translation="VVTGGGKGIGFTSAYFLARRWGVRLGLIGRS"
     aSDomain        complement(18445..18648)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS40275_PP-binding.1"
                     /evalue="4.70E-07"
                     /label="IEZ14_RS40275_PP-binding.1"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="1012"
                     /protein_start="944"
                     /score="22.0"
                     /tool="antismash"
                     /translation="VVRGLIADALELPPDVIGDGDRLLGDLHLNSLRVVQLAAEAAERT
                     RRAVPAAPPLFAEATVGSFAQAI"
     aSModule        complement(18445..21459)
                     /complete
                     /domains="nrpspksdomains_IEZ14_RS40275_PKS_KS.1"
                     /domains="nrpspksdomains_IEZ14_RS40275_PKS_AT.1"
                     /domains="nrpspksdomains_IEZ14_RS40275_PP-binding.1"
                     /locus_tags="IEZ14_RS40275"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(18952..19629)
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS40275_PKS_AT.1"
                     /evalue="9.10E-57"
                     /label="IEZ14_RS40275_PKS_AT.1"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="843"
                     /protein_start="617"
                     /score="184.6"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="DPIDTAVAQPAVFRASTAALRWLDRLGVTADAAVGHSLGEITALH
                     WAGALSRQDALHLVTRRGRIMADTSQAGTGMASLAAPAGTVTELIDDADLVIAADNGAV
                     QVVAGPLTEVDRVVKRARAKGITAGRLRVSHAFHSPAVAAAEPVLARHLADLAVAALPG
                     RVYSTVTGRELTAADDIRTLLARQLTAPVRFRQALELLAADCDLLVEAGPGHTLTAMAQ
                     SITD"
     CDS_motif       complement(19429..19551)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40275_0003"
                     /evalue="1.40E-15"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="684"
                     /protein_start="643"
                     /score="49.3"
                     /tool="antismash"
                     /translation="GVTADAAVGHSLGEITALHWAGALSRQDALHLVTRRGRIMA"
     aSDomain        complement(20092..21459)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS40275_PKS_KS.1"
                     /domain_subtypes="Enediyne-KS"
                     /evalue="8.40E-96"
                     /label="IEZ14_RS40275_PKS_KS.1"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="463"
                     /protein_start="7"
                     /score="313.4"
                     /tool="antismash"
                     /translation="IAVVGLGCRHPDASTPEQLWETVLARRRAFRPLPRERLDLGDYGD
                     PAGGPDTTDLRYAAVLDGWTFDRSRYRVPGPAYRVTDLAHWLALDVAGDTLTAAGFPGG
                     RGLDRRRAGVILGNTLTGEFSRAALMRLRWPYVRRNLVSALAARGWGTTELDGLLREVE
                     ESYKEPFAEPNDESLVGGLANAIAGRVCNHFDFRGAGYTVDGACSSSLLAVITACTYLR
                     DGDLDFALAGGVDLSLDPFELVGFSRLGALADSAMRVYDARPTGFLPGEGCSMVALMRA
                     GDAVAAGQRPIALIRGWGMSSDGNGGLTRPDVSGQRLALERAYARAGFGPETVALFEGH
                     GTGTEVGDRTELHALSEIHDGRRRPRPAALGSIKANIGHTKAAAGAAGLIKAALALQRQ
                     VIPPTTGCDEPHPLLRDPGAPLRIVREAEPWPDAPLRAAVSAMGFGGINTHVVLEAA"
     CDS_motif       complement(20305..20349)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40275_0002"
                     /evalue="2.20E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="392"
                     /protein_start="377"
                     /score="10.7"
                     /tool="antismash"
                     /translation="GSIKANIGHTKAAAG"
     CDS_motif       complement(20821..20868)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS40275_0001"
                     /evalue="2.20E-03"
                     /label="PKSI-KS_m3"
                     /locus_tag="IEZ14_RS40275"
                     /protein_end="220"
                     /protein_start="204"
                     /score="10.7"
                     /tool="antismash"
                     /translation="GAGYTVDGACSSSLLA"
     gene            complement(21477..22487)
                     /locus_tag="IEZ14_RS40280"
                     /old_locus_tag="GCM10010177_81450"
     CDS             complement(21477..22487)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893431.1"
                     /locus_tag="IEZ14_RS40280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81450"
                     /product="enediyne biosynthesis protein UnbU"
                     /protein_id="WP_179834684.1"
                     /transl_table=11
                     /translation="MNSANVESTTNPASAAPSGPAKDPRIIALRRFAISITVFNILGHT
                     VLGFEPSWATPLAAMAVAYVMELGLETLDAWATRRPVKYAGGPVAFMNFLMPAHITALA
                     CAMLLYANARLGPVIFAVIVAVASKYLIRVRIKGRPRHVLNPSNFGIAVVLVLFPWVGI
                     APPYQFTEWVGGPLDVAIPALILAAGTMLNAKLTRKMPLILGWIGVFALQALIRTPIEG
                     TATLSALLAMTGVAFVLFTNYMITDPGTTPVRPRNQFFFGASTALVYAFLVHIHVVYGL
                     FFALVIVCVLRGAALAIMGARQRATAQPAPLTEPKTAPRPAPARGGVLATGEEAK"
     gene            complement(22484..24427)
                     /locus_tag="IEZ14_RS40285"
                     /old_locus_tag="GCM10010177_81460"
     CDS             complement(22484..24427)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024907.5"
                     /locus_tag="IEZ14_RS40285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81460"
                     /product="VCBS repeat-containing protein"
                     /protein_id="WP_179834683.1"
                     /transl_table=11
                     /translation="MTRRIRVWLAPICAALLIVAGWYNARLPSVAQAENERLASRFAFQ
                     QQPLNGTASPRDIRTVAPAYKGIDHWISSVGAAVALADIDGSGRADEVCLVDPRDDSVM
                     LRPVPGTGSRLPATSLAPHGLPYDRTMAPMGCVPGDFNEDGRMDVLVYYWGRSPVLFLR
                     TPAALGKNEAFAPQELMRPYQVWNTNAVSLADLDGDGHTDIVVGNYFPDRARVLDPTAR
                     QSELQMQGSMSAGINGGVNRVLRFRSAEGGSRPSAVYGEERRLFSEEVAKGWTLAIGAQ
                     DLNGDGLPELYFANDFGPDRLLANESRPGKLKLRLLKGVRHLTTPKSMQLGRDSFKGMG
                     VGFTDINVDGVPDIVVSNITQEYGLLESNFAWVSTRKKVVGTDGRAYYDDHSERLGLSR
                     SGWGWDIKAGDFAGEGRDQIVQATGFVEGKDNRWAQLQELAMSNDEVLAHPRLWPNVQK
                     KDDISGDNPNRFFVRGSDGRYHDVAGRLGVADRQASRGIALADVDHDGRLDFAVANQWG
                     QSHFYRNVRSAQRPYLGLRLLSPPGCGTRQGGSAATPPAGSAGVPAIGAQVVLDSGAKG
                     QRTGQVYPANGHAGVSSPELLFALDGTAAPVPVTITWRDSCGTRHTGKVQATPGWHSML
                     LGPDGSIREMAS"
     gene            complement(24432..25388)
                     /locus_tag="IEZ14_RS40290"
                     /old_locus_tag="GCM10010177_81470"
     CDS             complement(24432..25388)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019624.5"
                     /locus_tag="IEZ14_RS40290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81470"
                     /product="DUF1702 family protein"
                     /protein_id="WP_179834682.1"
                     /transl_table=11
                     /translation="MAAVGNLLTPPLRGFLEIDPKTLDVERLGFPPGDPQARARLADVV
                     QSFATGFNTSLGADPASLDFQALPHDLRGFAFEGAAMGVALADLGTFSGGRRVRALAEG
                     PGARYIHLIHVGVGWAYARTHVHPWTGIRFGRPLLRWLVWDGWGFHQAFFKSRRVLVRH
                     WVERPARGNMRTIRDQGVGRALWFYAGGDPVEVAETIGAFPAARRSDVWAGIGLAAAYT
                     GALTPERLGELLDRAAGFEEHIAQGAAFAAKAHVESQEVPERSAAAIETLAGAAPAVAA
                     AWTDEAAVTAERCGSGPEGYEVWRARVRQAWRKHNEG"
     gene            complement(25595..26179)
                     /locus_tag="IEZ14_RS40295"
                     /old_locus_tag="GCM10010177_81480"
     CDS             complement(25595..26179)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LmbU"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014910516.1"
                     /locus_tag="IEZ14_RS40295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81480"
                     /product="LmbU family transcriptional regulator"
                     /protein_id="WP_179834681.1"
                     /sec_met_domain="LmbU (E-value: 2.4e-73, bitscore: 237.0,
                     seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLDQSARPRRSGLELPPRLPFETWQRIGRQISLISDCSRWWLGD
                     WLIYGERHYPNRYRMAIEATSLDYQTLKNYAWIARRIPRSRRRDQLSLQHHAEVAALPP
                     SDQEHWLQQAAELGWTRRELRKRLREIRNGDDSKKPDEATVRIDVIAERQLRWQEAAEA
                     MELSLAEWIVVILDQAAGQVGGAVGSNDEEA"
     misc_feature    26241..26257
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    26504..26519
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.08"
                     /tool="antismash"
     misc_feature    complement(26527..26542)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            complement(26757..27089)
                     /locus_tag="IEZ14_RS40300"
                     /old_locus_tag="GCM10010177_81490"
     CDS             complement(26757..27089)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024736.5"
                     /locus_tag="IEZ14_RS40300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81490"
                     /product="transposase"
                     /protein_id="WP_179834680.1"
                     /transl_table=11
                     /translation="MPDELWEIVGPLIPEFAPRRQGGGTAPVNDRMVFTAIVYVLTSGC
                     AWRHLPAEFGVSVPTAHRRFTAWTRAGLWPRLHRAALEEPGARGQLDWASAIVEAAAAR
                     AKRAAN"
     gene            complement(27730..29013)
                     /locus_tag="IEZ14_RS40305"
                     /old_locus_tag="GCM10010177_81510"
     CDS             complement(27730..29013)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015094.5"
                     /locus_tag="IEZ14_RS40305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81510"
                     /product="AarF/ABC1/UbiB kinase family protein"
                     /protein_id="WP_179834679.1"
                     /transl_table=11
                     /translation="MVDRASARSLAARTVRIGACGGAAAVRMAAIAATSSEGTRGTRLA
                     AELARLMERLGGAFVKTGQILGTRVDLVGETLATALGRLHDDVEPMTPEEALRTMRAGL
                     GLTPPEFVRAVGGPSVAGGSIACVYRAERGGRVLAVKVRRPGAGAAIAADMAVLRAAAG
                     AAARLPAFRRVPFMEIVDQVGDCLMAQLDFGAEAANLRRLHDDLAGIPGVVVPRPVPEL
                     SGDGVIAMEFIEGLDRGVIEDLPARVREAQITSLVHAVYRMLFIEGFLHLDLHQGNTYF
                     KPDGTVVLLDAGLVFRMSPRARERFTGFFAGMIRGDGEVCADILLSTVRRTDPETDIAA
                     FRAEISDLVLRNVGMVARDFDLPAFCLDLFDLQRKYRLYAEPEFIFPMLCLLTLQGVVK
                     RHHPMMDFQLEAAPFVMHGLLVTSGATG"
     gene            complement(29013..29744)
                     /locus_tag="IEZ14_RS40310"
                     /old_locus_tag="GCM10010177_81520"
     CDS             complement(29013..29744)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS40310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_81520"
                     /product="hypothetical protein"
                     /protein_id="WP_179834678.1"
                     /transl_table=11
                     /translation="MEHVRMTRPARPNLSAGGLTSYGFAIEAAIGRRPMRYLIGRRFSD
                     HSAVTTLFVLHPQILAGSHVWITENSARGECEVETHIPTMRNSVRLVERYLFDCLPLTD
                     IGYLDLMAWRYPGLGATPEDVEVDMSWSRWPAAEPRCYLGPVTTPGLTVTEAIDHETGL
                     VVARAVERLRIPFRRWEVVEMGRPDVGGLPERVRACRTRTGGWTDFRRVGEPVPVPQEA
                     FDAGPARLREALERGLSGTAA"
     misc_feature    29916..29927
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.71"
                     /tool="antismash"
     gene            complement(30126..30776)
                     /locus_tag="IEZ14_RS40315"
                     /old_locus_tag="GCM10010177_81530"
     CDS             complement(30126..30776)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077908.1"
                     /locus_tag="IEZ14_RS40315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81530"
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="WP_179834677.1"
                     /transl_table=11
                     /translation="MNQRRNYGQYCGLAGALDIVGERWTLLIIRELLTGPCRYNELLAN
                     LPGLGTNLLADRLKFLTEVGIIRQRPREGSKVRVYELTEQGEGLREAVLVLARWGLGVL
                     TEPKAEYIVRPRWAVLAVEAMAAPTVEGPDEQYEFRIDDDVFHITVHEGKVSVAHGKAT
                     VEPALVVHTDAVTFVDIGAGRLDPLEATLTRRIVMEGDEDAIIRCSRLLGLVA"
     misc_feature    complement(30802..30817)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 20.79"
                     /tool="antismash"
     gene            complement(30924..32426)
                     /locus_tag="IEZ14_RS40320"
                     /old_locus_tag="GCM10010177_81540"
     CDS             complement(30924..32426)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="IEZ14_RS40320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81540"
                     /product="radical SAM protein"
                     /protein_id="WP_179834676.1"
                     /sec_met_domain="PF04055 (E-value: 8.4e-18, bitscore: 56.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALRDVRVLLLYPPNQTAPGTVCKPNGSLAYPNLGGALRDHGVDV
                     RVFDACVGDDSDSLDAIFDKPGQLPSGLLRTGVSDERILEEAAAYDIVGITSIFTDQET
                     MVLHCARLLRAAFPEKVLVSGGVNARSRLPQFFRAGFDVVCLSEAEGTITKIADEVRRS
                     ARPDFAAISGVAFLDSGEIRVNPARPDDVVWDLDTLPMPAWDLLPNERYWTLARPHSGV
                     WESGTELRYADMMTSLGCPFHCAYCHIAGEQEGSMSGPIGRYRAKSDDRVLRELDVLKG
                     LGVEHVMIEDDSLLGNKKRALRLLRKIQGAGVNICDLNGINIIHLLKRWKPDHEVLEAL
                     AEAGFTQLNLPFESGNLRILRKYASNKLNIEMADIESLIVALKDYGFKIFGNYMMGYPD
                     ETLEEIQTTINLARDHVSFGLDAANFFIVVPLPGTPLFDTAISEGHLRSDFDPDTMNIY
                     RANMSGTVVPSHVLEELRSRAWEEVNSSTWKNAKKAWAATES"
     misc_feature    32551..32569
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.84"
                     /tool="antismash"
     gene            32610..33344
                     /locus_tag="IEZ14_RS40325"
                     /old_locus_tag="GCM10010177_81550"
     CDS             32610..33344
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016908.5"
                     /locus_tag="IEZ14_RS40325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81550"
                     /product="FkbM family methyltransferase"
                     /protein_id="WP_179834675.1"
                     /transl_table=11
                     /translation="MSHGSSPASQGHALTEIDRSAAPVYVRWERQLPGLMDRLGVAPVG
                     VVQVGAHIGQEVPALVRCGFRRLVMVEPNRDHSAALARELGRHLSGRPEPEGGRPAQEV
                     VLAAAGRERGTATLHVTEYDQQASLLAPLPPMTVTRLDTTEVVPVREVQHGCNVLVVDA
                     QGAELDVLAGADLDRLDLAVIEGSAEARYHCGATRQAVAAYMQDRGWRLVANWTHARAN
                     VADMAWLAPSTSLRATYRADRG"
     gene            33383..33991
                     /locus_tag="IEZ14_RS40330"
                     /old_locus_tag="GCM10010177_81560"
     CDS             33383..33991
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017572891.1"
                     /locus_tag="IEZ14_RS40330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81560"
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase family
                     protein"
                     /protein_id="WP_179834674.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 2e-46, bitscore:
                     148.6, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHVSETAVPGAYVFTSDHNSDRRGDFFEVMRADVLDVTLGRPFVP
                     RQINCSTSRRNTLRGIRSVTVPPGQAKYVTCVSGAVRDIVVDLRVGSPAFGHHAVNELY
                     AGSGRSVYIPEGAGHAFLALTDDTCICYALSSTYTPDAQISINPLDPDLALPWGITEPP
                     LLSDGDAAAPTMAETISAGLLSPWQEADAPSTRLRGSNR"
     gene            33988..35043
                     /locus_tag="IEZ14_RS40335"
                     /old_locus_tag="GCM10010177_81570"
     CDS             33988..35043
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017579245.1"
                     /locus_tag="IEZ14_RS40335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81570"
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="WP_179834673.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.5e-10, bitscore:
                     31.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVLSGGSGMRLRPFSHSMAKQMMPIANKPVLEYVLLNIRALG
                     VTEIGIIVGDRAQEIIDFAGDGSRFGARVTYIHQDRPLGLAHCVILARSFLADDDFVMY
                     LGDNMLPHGVADVALDFAAQRPDAQVLVHKVADPRAFGVVELDVEGRVERLVEKPEDPR
                     SDLGLIGVYFFTPAIHEAVASIEPSARGELEITDAVQWLLARGADVRASEYAGYWKDTG
                     RAEDVLDCNRRLLETLQPCIAGDVDAHCEIDGAVVVEAGARIVRSRIQGPVIVGAGSVI
                     EDSHIGPRTSIGRGCVLRRTGVTGSIVLDNASISGFAGLHDSIIGRNASVSASARPRLV
                     VGDDTRVEVPA"
     gene            complement(35095..36015)
                     /locus_tag="IEZ14_RS40340"
                     /old_locus_tag="GCM10010177_81580"
     CDS             complement(35095..36015)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541485.1"
                     /locus_tag="IEZ14_RS40340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_81580"
                     /product="arylamine N-acetyltransferase"
                     /protein_id="WP_179834672.1"
                     /transl_table=11
                     /translation="MPGQHTSGSAPVPEEPGGSRYVAEYLERLGIGDPGEPSLSGLFAL
                     HRAHVERVPYEVLEIQLGRPTTADPRYAAGQVLKGRGGYCVQLNGAFSTLLTALGYDVT
                     WHRAGVHAGRKLPPVGPAEPAPHLVLTVSVEGGAWMVDVGLGDGLHEPLPLRAGAYRQG
                     PFTFHLGPSRFGSGGWRFEHDDGGAIAGLDFSMEPAGPADFAEWHPYLATDPESRLVRT
                     VAVMRRDATSVDSLTGCMLRHVDDSGRTTRELGTFTEWYGALAEVFDLPLADVGPQERT
                     ALWTKVRGAHDAWLEARARRSAART"
     misc_feature    complement(36067..36083)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.15"
                     /tool="antismash"
     CDS             complement(36130..>36502)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=3
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024110.5"
                     /locus_tag="IEZ14_RS40345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_189269987.1"
                     /transl_table=11
                     /translation="PDGGPAGVVLALLFLQVFAFSLAWIWALVGVAVRQAASAQMLIIT
                     LDSVLLFGSNIIAPRETMPSWLQTVIGVNPITHAATAVRGLMQGTETAGQMGRAFLACA
                     ILVAVFAPLTAYAYSRRGRG"
     gene            complement(36130..>36506)
                     /locus_tag="IEZ14_RS40345"
ORIGIN
        1 gcccggacgg cgggccggcc ggcgtggtgc tggcgctgct gttcctccag gtgttcgcct
       61 tcagcctcgc ctggatcgga accttcgtcg gcgtcagcgt tcggacgccg accgcggcgc
      121 agacgctgag ctggacgctc ctgttcgtcc tcgtcgtcgc cagcaacgtc atggtgccgc
      181 agcagacgat gccgggctgg ctggaggcgc tgatcaaggt caatccgatc agcgtcgtga
      241 cgaccgccat gcgcgggctg atggacggca ccgtgaccgc gggccagatg ggctgggcgt
      301 tcctggcctg cgcgatcctc gtcgcggtct tcgcgccgct gaccatgtac cggtacggcc
      361 gcgcccgtcg ctgagcgcgc tcacagtgcg tgcaggcaga gcagcagact gcgggcctcg
      421 atgttgacct ggtagctctg gcgggccagc tccatcacct ggggcaccgt gagccagcag
      481 aagtccgggg gcggttgggc ggggaagccg ccgccgacct cgaccacgag atggcgcgtc
      541 agggcctgcc ggaaccggcc gccctcctct gactgcacca cgtcgtactg cacccggacg
      601 gctctggaca ggacgagatc gagataccgc gggcgccgct cgccggtcgc gtcctcgtag
      661 ttctcggggg tgcactgcac ggtggggccg agctccacgg tgtcgcggca tcccggacgc
      721 aggtcggcgc ggaccagaag gtgccggacc ccgttgatgc ggcggacgac gagggcggcc
      781 agcccggtgc cgctgggcgc gagcagcggc tggcaccagt cggacacctc ccggttgccc
      841 gcgtggacct ccaccccgac gacgctgaag tatctgccgt cgggacggcg gatcgcctcg
      901 gcgtcccgct cccatccgtc cacggagtcg agggggaccg cgcgcgtcgt gagcgtgtac
      961 gcggacttgc gctcggtgag ccagctcctc acctgcaccg gcgagaggag cgcgctcccg
     1021 gaggcggccg gcgccccgtc gcccggcagc gcgcccatgt acggggccga ggacagcagg
     1081 caggccagga cggtcctgga gtccatgttc acgacgttgg ggtggtgcag gaggtcgagg
     1141 atctggccga gcgtcatcca ggcgaagtcg tcgtgcggct ccacctcgtc ggtgacctcc
     1201 atgaccacgt tccggttgcg cttggcccag aaccacgccc cctgctcgga ctgcaggacg
     1261 tcgaccagca cccgggcccg cccgggttcg gtgaagtact cgacgaaccg ggaccgggcg
     1321 ccgcggtgcg tccgcaggta gttgctcgac gtggactgga cggtcggcga cagctgcacc
     1381 gtgttcacgt tgccgggttc gatcttggcc tgcatcagga agtgcaggac gccgtcgatc
     1441 tccttggcga ggatgcccac gatcgcgacg tcctgctggt agatgatcgg ctgccgccat
     1501 tcgggggtgg cgccgtagtc ggtacgggcg tggatgccgc ccacggtgaa gaagcggccg
     1561 ctctcgtgca cgaggtcgcc cgagtccggg gcgaacgacc atccggccat gcgctcgaac
     1621 gggatgcgcg tcacctggac cgggacgcgg cggcggcgct cggccagcca gtcgacgatg
     1681 tccccggccg ggcgcggccg gtactcggcc gacgcggcga gccgccggtc cagctcgggc
     1741 tcctcgctcg gcgccctcag ccgagagccc gcgttcacac ccgccatacc tgccatgccc
     1801 gcctccgtcc acggcccccg gatctggccg ccgttcgcgc tcggctgtac gatttcactt
     1861 aagttacata tagcatctgg cggcgagaag ggagaccccc gtgtccgcca cggagcgcga
     1921 cgtcgccttc ggcccggagc acgccgaggt ctacgagctg acgtaccggc accgcggcaa
     1981 ggactggggc gaggaggcgg cggaggtcac gcggcgcatc cgggagcacc gtccccgtgc
     2041 ccggtccctt ctcgacgtcg cctgcggcac cggggcccac ctggaggcgt tccggtccgg
     2101 cttcgaccac gtcgagggcc tggagatctc acgctcgatg cgcgagcggg ccgtgcggcg
     2161 gctgccggga gtgaccgtcc atgacggtga catgcgggcc ttcgccctcg gtcgcgcctt
     2221 cgacgcggtg acgtgcctct acaccgcgat cgcctatctg ccgagcgtcg ccgccatgcg
     2281 cgccgcggtc ggagccatgg cccgccatct cgtccccggc ggggtcctcg tcatcgaacc
     2341 ctggtggccg ccggaaagat tcatcgaggg gttcgtcgga gccgacctgg tgcgggacgg
     2401 cgacacggtc gtcgcgcggg tctcccactc gatccggcgc gaccgggccg cgcacatgga
     2461 cgtgcgctgg ctggtgggcc gtcccacggg catccgcgag ttccgcaccg tggagacctt
     2521 caccatgttc accgcggacg agttcctggc ggcgttccgg gactccggat gcgacgtcga
     2581 gcacgaggag gccggcctga acgggtacgg ccttttcgtc ggagtccgcc gcggccgaac
     2641 cgaggccgag ccgaggccga ggcggacggg tgctactcgc cccagcgcag gtaggtgatg
     2701 ggcggctccc ggccggggag ggtgcgcagg gtcaccacgt cgaggccgac ggcctcgcgc
     2761 agcgcggccg tctcccccgg ccacttggag taggcgatct cgtcgaaggc gagcacgctg
     2821 cccttggtca ggtagggccg gatcgcctcc agggcggcgc gggtcggcgc gtagatgtcg
     2881 aggtcgaaat aggccagcgc gatcacggtc tccgggttgt cggcgaggta gcgcggcagg
     2941 gtctcgcgga cgtcgccctg gaccaccgcg gtccgccgga cgtgtgcgaa gggctcgccg
     3001 gactcgtgcg cgtcgagcac ctcgcgcagg tggtcggggt agccctcgct cacggcgaac
     3061 cggccggcca ccgcattggg cccggcccgg tcgacgtcgg cgatgtcggg gaaaccggtg
     3121 aaggtgtcga aaccgatgac gcgccgcacc gaggtgtacg gctcgtggca cccgcgaagc
     3181 gcggtcagcg tggccaggtg ccgcccgtgg agcacgccga actccatgat cacgccgggg
     3241 acgtcgagga tcatgcggta cagcgcgtcc atgcacagca ggtcggtgag ctgctggcgc
     3301 cgcaggtaca gcgccagatt gtcgatcagg tactcgggcg ggatgggggt gtcgcgcagc
     3361 agtcgggtga gccgctcgcg cacgtcgcgc tcctggtccg actcgcgcgc cagcgagcgc
     3421 gggtccctgt ggttcggcgg ggtcacctgt ctcgtcctcc cagcggcaga gatcgcgtca
     3481 agacgggatc agctcatcca cgcggcgggc gccggtccgc cgcggccgac gggcgggaag
     3541 agggcctcca gccggtcggt ctcctcctcg gtcaggggct tgtccagcgc cctgaccgcg
     3601 ccgtcgacgt ggtcgggggt gcgcgggccg acgaggacgc cggtcacacc cggcctggac
     3661 agcgtccagg cgaggccgac ctccgcgggg tcccgcccga tgtccgcgca gaaccgctca
     3721 tagtcggcga tggccgcctc gtgctccttc agcgcgtcga ccgcgcgccc ctgcgcggac
     3781 ttgaccgcgg tcccctccgc cttcttgcgc agcacgccgc cgagcaggcc gccgtgcagg
     3841 ggcgaccaga ccagcacccc gagcccgaga gccgtcgccg cgggaatcac ctcgagctcc
     3901 gcgtgccggg tgacgaggtt gtagacgcac tgttcggagg ccagccccgg gacgcggcgg
     3961 cgggcggcgg tctcctgggc cagggcgatg tcccagccgg cgaagttgga cgagccgacg
     4021 tggcggatct tgccctggcc gatcagcagt tccatggcca gccagatctc gtcccagggg
     4081 accgaccggt ccacctggtg catctggtag aggtcgatcc ggtcggtgtt cagccggcgc
     4141 agggaggcct cgcacgccgc gacgatgtgc cgcgccgaca ggccgcggtc gcccgggtcg
     4201 tcgctcatcg ggcccccgac cttggtggcc acgacgacct cgtcccggcg gcccgggcgt
     4261 gccccgagcc agtccccgat cacctcttcg gtgtggccct tgtagacgcg ccagccgtag
     4321 atgtccgcgg tgtcgacgag gttgatgccg ctcgccaggg cgtggtccat gaggcggtgc
     4381 gcgtccgccc cgtccacacg gccgccgaag ttcacggtgc cgaggccgag gcgactgatc
     4441 cgcagatcgg tggaacccag cgacgcgcgg aactctccgg ggtggggcat cgaccgcctc
     4501 ctcaggctct cgaccggctt tcacgatact agttattcaa gtcagattcc cctatgtccc
     4561 ctactatcgc gtcctgcgac gtcaatgcta tcgttttctc aagtgtagga cctttggcgg
     4621 gtaaaggtgg tccacatggc cccgagggcg gtgccgcatt ggcgcgggac agcgatccgg
     4681 tccacggcgg acgacccgcc gagcgtgtcc ggcgacagat cctcggtgac cccaccgagg
     4741 aaatcggggg gtgggggatc gtcattgact ccgacggcat cccacgcgtg agcacggcac
     4801 ggtgacgggg aacgcgccgc ctcttccggc ggcgccggac tgctgatcgt ccccgcgcgc
     4861 cgtcgttgga acgcggccga attccgccgg ggcgaggccg cggccgacct cgatggaccg
     4921 tctgacccga tctgctcttt gcttcgaccc gtcgaatcca gggtcgtgcg agatgggaga
     4981 aacgcccatg gtaacgaagg catccggcgg ggatgctgtg ggagccgccg cacccgatcc
     5041 cgcatcggac cggcctcgga agttcatccc ggagctcgaa ggactgcgcg gcgccgtcgt
     5101 gctgctcgtc gtcctcggcc acaccggagt ggcgaccagc gtgcagggct ggtcctacat
     5161 gcactccacc gggaacggcg tctgggccat catgctgaac cgggtggcgg tcgccttccc
     5221 gatctggttc gtgatgaccg gctacctgct gtaccgcgcg ttcgcgctgt acacgctcac
     5281 cggcgaacgg aagccgaacg ccaagcgcta cttctggcgc cgggcgctgc ggatcctgcc
     5341 cgcctactgg gtactgacga tcaccgctct cctcgtgctc aaccgcgaca ccgtccacgg
     5401 ggtctgggaa tggatccgcc cgctgctcct gctgcagatc tgggagcacg gcgccattcc
     5461 catggggatg atgcacacct ggagcaacgc caacgacttc ctgttctacc tggccatgcc
     5521 ggtgttcgcc tggctcctcc accggtacgc gcggcgcgcc gaaagccccg aggcccgggt
     5581 gcggcggctg ctcgtgccgc tggccttccc ggtgttcatc ggcttcggct tcttcacctg
     5641 gctccacttc ccgcagttca gggacgaccc gatgaagctg tggccgacgc agtacttctg
     5701 gccgatgagc tacatgggct ggctctcggt gggcatgatg ctggccgtgc tgtccgccgc
     5761 cgcggagacg cgccccgacg cggtgccgcg ggtgtaccgc ctgatcggcc ggcatccggg
     5821 caagctctgg ctgggggcgc tcctcatctt cgtcctggcc tgcctctccc cgctcgcgga
     5881 ctaccgcctg gtggactacg tcgcagcgcc ggcggcggcg gccgactact ggctcttcct
     5941 cgccttctcc gtggccgtct tcgcgccgct gaccgtgccg ggcgtgcggt tcaagctggc
     6001 gggcctgctg ctggacaact cgttgctgcg attcttcggc cgcatctcct acagcgtcta
     6061 tctctggcac atcttcgtct acgcccagtt cgtcggaccg ctcttcgcgc ccgaggtcgg
     6121 cggctactgg gaagtcctgg gcgtcgaact ggcgctgtgc gtgatggtcg gctacgcgag
     6181 ctacatcgtc gtcgagaagc cgttccacat gctccggccg cggctgggca aggcgccggt
     6241 cgagttgagc gtcgccgtca gcactcccgc cgaggcgcac gccacggcgg gcgcggtgcg
     6301 caccccccgg gacgcgcagg cctgaccaac gcccgcggcg ggcgagacga tgccccggca
     6361 cgtctcgccc gccgcgggcg tgaagaccac cagggaacgc cgaggaggcg gggcgatgag
     6421 actcctggtc accgggggcg ccggtttcat cggctcggag ttcgtgcggg cgacgctgcg
     6481 cggcgagctg ccgggcacgg cgggcgcgta cgtcaccgtg ctggacgcgc tcacgtactc
     6541 ggggaacctg cagaacctgg ccccggtcgc cgggcacccc cgctaccggt tcgtgcacgg
     6601 cgacacctgc gatcccgacg cggtcgacgc ggccgtggct ggccaggacg cgatcgtcca
     6661 tctcgccgcc gaatcgcacg tggaccgctc gatcgacacc gccacgccct tcgtgcggac
     6721 caacgtgctg ggcacgcaga acatgctgga ggcggcccag cggcacggcg tcggcaggtt
     6781 cgtgcacgtg tccaccgacg aggtctacgg atcgatcgcc cagggggcgt gggcggagga
     6841 cgctccgctg ctgcccaacg gcccctacgc gtcggccaag gccgggtcgg acctgctggc
     6901 gctggcctgg caccggaccc gcggcctcga ggtcatggtc acgcggtgca ccaacaacta
     6961 cggccactac cagttcccgg agaaggtgat cccgctgttc gtgaccaacc tgctcgacgg
     7021 ccggcgggta ccgctctacg gcgacggccg ccaccggcgg ggctggctgc acgtgtcgga
     7081 ccactgccgc gcgctcgacc tggtgctgcg atcgggccgc ccgggcgagg tgtaccacat
     7141 cggcggtggg aaggaactgt ccaacgagga cctgacggac ctgctgctgg aggcgtgcgg
     7201 cgccggctgg gaggcggtcg accacgtccc cgaccgccag gggcacgacc gcaggtacgc
     7261 gctcgacacc accaagatcg aggaacggct cggcttcgtc ccgcgcgtgc gcttcgagga
     7321 cgggctcgag gcgaccgtcg agtggtaccg cgcgaaccgc gcctggtggg aacccctgaa
     7381 ggccggtctc cgggagctgc cggggccggc gctcagatcg cctcgctgac cgccgacatc
     7441 gtgtagtcgc ccacccggag cgcgggcatg gccgtccggg gcgtggagtc gtccctctcc
     7501 ctcggcaggg ttcgttcggt gcggccgatc tccgtcaccc ggcccagcag gtccaccggg
     7561 ctctcgttga agcggaagtt gttcgtctcc cccaccactt cgccgtcctc caccaggtag
     7621 acgccgtcgc gggtaagccc ggtgagcagc agcgtccggg ggtcgacgtc gcggacgtac
     7681 cacagcgagg tgaccaggag cccgcgcctc gtggtcgcga ccagctcggc gagcgaccgg
     7741 ccctcccccg gcccctccag caccagattg ccgacctgcg gcgtgaccgg cagcccggtg
     7801 agatcggcgg agtggcgggt ctggaccagg cgggtgagga cgccgtcgtg gatccactcg
     7861 gccggcgaga gcggcaggcc gttgtcgaac accgaaaccg tgtccgcgaa cacctgagcg
     7921 acgtcggcgg agccccgggc ggcgacgaac ggcgcgcacc gcaggcccgg ctcgtgcggg
     7981 tcgctccgca gcgtgagcgg tgcgccggtc aggcgctcac cgatccgggt cccgccgtcc
     8041 gggccgccga acacggtgcg cgcgtcgacc gcgtccttcg ccccggccgc gcggtaaagc
     8101 cgcagcatga gatcggcgac gcacgacggg gacagcagca cctcgtagcg cccggcgggg
     8161 agctcgacgc gcctgcgtcc ccggtcgagc cgctccccca gcccctcgta caggggaagc
     8221 ggatcgatct cgccgaggtc ggccgccccg gtgccgctcc acgtcgaggc cgcgccgtcc
     8281 ccggtcttgg cggtcaggtc cacgacgccc gaggtctgga cgtgccgcag ccgcaggccg
     8341 gtggaggacg ccagccacgt ggcgtgctgc cgctgttcgg cgtagccgta cagcaggcgg
     8401 cgctccccgc gggcccgctc gaacgtcgcg gcgaggctgg cggcgaaccg ggcgaggacg
     8461 ccggccgacg ccgtgggcgc gggctcggcc cagtccgccg aggagggcac gacgtcgccg
     8521 gtcagcaggg gacgggcgtc ggcggcgggc gtcgccgtgc gcgcggcgcg ttcggccgcc
     8581 gccacgacgg cccgcaccgc ctcctcgtcc accgcgccgc ggtgcgagac gacgcccgcc
     8641 gcggtgccgt gcgcgcccgg ggtcacggcg atcaccgtca gcctcgtgtc cgcggtgaga
     8701 ccgctcgacg tcagcgcgtt gcccgcccac cgcgcgtgcg ccgtggcggc ctcgtcgacg
     8761 atcgccacgt aggcgtcggc gtccttgccg acctggacgg ccagctccgc gagccgtggt
     8821 gcgctaccga tctctgctgc cctcctcgac cgtggcccgc ggaccgggaa ccgtgctccg
     8881 aggcgccgcc cgggaggtca cggcagcccg tccgcgccgg tgtcgatgac cttgatcccc
     8941 ctgaacacgg ccgcggggca gccgtggccg gccgcggcca cctgcatcgg ctggcccttg
     9001 ccgcacaggt cggcgccgaa gagccggtag gtgtcctcgc cgccgagtgc ggtcagcgcc
     9061 gaccagaact ccgtggtcga ggcctggtag gcgaccccgc tcagttgacc ctccaggcgt
     9121 ccgttgcgga tccgatggca tcgctgggcg gtcatctgga agttctggcg gcgcatgtcg
     9181 atggaccagc tgtcggagcc gacgaggtag atgccgtcct cgatccccgc gatgaggtcg
     9241 tcggtggacg ggcctccggg cgcgggacgg agcccgacgt tgggcatccg cggcagcggc
     9301 acgtgcatcg cggactcggc gaacgagcag ccgttggaac gtcccaggcc cgccaggccc
     9361 gcggtgcgcc ggtcgtgctg gaagccggtg aggaccccgt cccgcaccag gctccaggac
     9421 tgcgccgcca ccccttcgtc gtcgaagccc accgtcgcga ggccgtgctc ggccgtgcgg
     9481 tccgcggtga cgttcatcag cggcgagccg taccggtgcg agccgagccc ctccggagtg
     9541 aggaacgtcg tgccggtcga ggacgcctcg tgccccagcg cgcggtccat ctccgtggtg
     9601 tggccgaccg actcgtgcac ggtcagccag aggttggacg gatcgatgac caggtcgtag
     9661 cggcccggcc gcaccgggcg ggcgcggagc ttggcggcga ggtgcgcggg cagctcggac
     9721 agctcgcgct cccagtccca gccgtcgccg gcgaggtact cccagccccg ggccgtggga
     9781 ggcccgaggg tgcgcaacgt cgccgtcccg ccaccgcgcg ggtccgcgcc ctggacgaag
     9841 aacagcgggt ggacccgcac ccgctgctga gtggtcaccg tgcccgcgag gtcggcgtag
     9901 aacttgttct cccggacgac ggtgaggaag gccagcacgt gctcgacctc cggcgcggcc
     9961 agcagccgcc ggctccagtc ggccatgagc gcgatgcgct cctcctcggg cacctcgaac
    10021 ggatcgaccc ggtacgacga gacccacgtc gcgccgtggt ggaccggttc gccgaccggc
    10081 tcaccggagc cgccgccgat cgccgagcac gcgcgggcga cggccaccgc ctgctcggcg
    10141 gctccggcgg cggcgcgcgc cgtcagctcg ggggcggcgg cgaagccggg gacgcccccg
    10201 tgccacaggc gcacggccag ccccgtgtcc gtggcgtcct gcccgccgcc gaggacgccg
    10261 tcgcgcagca gcagccgcgc cgtgcggacg cggtcgaggc ggaaggacgc gtgcccggcc
    10321 ccgagcccgg ccgcgcggcc gagcgccgca tcggccaggg agtccagcgg gagggcggag
    10381 aacgaggcgt ccacaccacg tcgcacgctg cctcactttc cacacccggg cacgtcctac
    10441 tagaaaaaca tattgcctcg cgttgtaaaa gccgaccgcg aacgccaaat ccagcaactg
    10501 ccggggaagg caatccgtcg atctgggcga taactatagt ttttgatagc attgacattc
    10561 gaccccgtcc ggtgcggagg gaaccaggtc cgcgacggga cgaccgggat cggtgcgacg
    10621 ccgaggggac gcgatggacg atgtcgcggc tgctgccgtg gggggcaagg tctgtgacgc
    10681 ggcgaccgcg gcggccctca tcgaggacgg gcagtccgtc gcgagcaccg gagtcatcgg
    10741 ctggatcacg cccgacgcgg tcctgcgcgc catcggcgag cggttcgagc ggctcggctc
    10801 cccccgggac ctgaccttct tcttcccctg cgccaccggc gacgccatgg acatcggcgg
    10861 catggacggc gtggcccgcg aggggctgat gcgccggatc gtcgccggct cctacatcaa
    10921 tccgcggcat ccgcgcaccg gtgcccgccc ggcgctcacc gagctgatcc gcgacgatct
    10981 cgtcgaggcc tacagctggc cgatcggcgc cgccatgcac tggctgcggg aggtcgcgcg
    11041 gcggagcccg ggctacctca cccgcatcgg tctcggcacc ttcgccgacc cgcgccacgg
    11101 cggcggccgc ctcaccggcc gggccaagga cgacctggtg gaggtggtcg agctgcgcgg
    11161 cgaggagctc ctgctctacc ccacctggcc gctggacgtg gggatcatcc gggccagcag
    11221 ctccgacgcc cacggcaacc tgtccttcga ggatctgccg ctcacctccg ccgccctcgc
    11281 cctcgccctc gccgtcaagg cgagcggcgg caccgtgatc gcgcaggtgt cgcggatcgt
    11341 gccgcgcggg tcccggcccg cgcgcgaggt gcaggtcccc ggcgtgctcg tcgaccgcgt
    11401 cgtggtcgcg gcgggcgagc tgatcgggac ggaggtgcgc aacgaccccg gctacctgcg
    11461 gccggtgccg cacccggtcg ggcgcctgcc gcgcctgcgc cccgggccgg gaaaggtcat
    11521 cgcgcgccgt gtcgcgcggg agatccgccc gggtgagacc acgatcctcg ggttcggcgc
    11581 ggcgtcgagc gcgatcctgg ccatggcgga ggacggcgcc ttccgcgacg accggctgga
    11641 cgactacacc ttcaccaccg agcacggctc cttcggcggc gtcgtcatgg gcggctggca
    11701 gttctcggcc aactactccc ccgaggcgct ggtcgacggg acctaccagt tcgacttcat
    11761 cgacggcggc ggctgcgcgc tcgccgcgct ctccttcgcc cagctcgatg ccgccgggaa
    11821 cgtcaacgtc agccgcttcg cgggcacgag cccgggcggc ggcggattcg tcgacatcgc
    11881 gcacaacgcg cagcggatcg tcctcggagg caccctcacc acccagggcc tcgacgtctc
    11941 ctgcgagggc ggaaggctcg acatcctgcg ggagggcgag atccagaagc tcgtgcccga
    12001 ggccgaccac gtcacctacg cggtccgcgc cggtctggag cgcggccagc gggccctcgt
    12061 cgtcaccgaa cgcgccgtgt tcgagatgac cgccgaagga ctcgtgctga cggaggtggc
    12121 gcccggcgtc gacgtccggc gggacgtcct cgggcagatc ggcttccctg tccgtcccgc
    12181 cgccggcgtc accaccatgg ccgccgacct gttccgtccg tagccgcgca ccggggagat
    12241 cgatgaaccg catggtcaag cctgacgagc cgcacggccg ccggtccggc ggccccgcac
    12301 cggcgcgtca cgacggagga ctcgtgtcgg cggcggcgga cgaggccgtc cccgcgctgt
    12361 gggcgatggc ccagctcgcg accccgatgg cggtgcgggt ggccgcgacg ctgcgcatcg
    12421 ccgaccacat cgcgtcaggt ctgcggaccg tgcccgaact ggccgaggcc accggcgccg
    12481 cccctgacgg gctcgcccgc ctgatgcgct acctcgcggt gcgcggggtg ctgagcctgg
    12541 acgactccgg ccggtacggt ctgaccgcgc tgggcgagcc gctgcgcggc gatcaccccg
    12601 ccggccttcg cgcctgcctc gacatcgagg agggcggccg ggccgagctg tgctacgtcg
    12661 agctgctgca cagcgtgcgc acgggcgagc ccgcctaccc gcggcgcttc ggcctctcct
    12721 tctgggacga cctggccgcc gagccccgcc acgaggccgc cttccgcgcc atgcttcgcc
    12781 ccggcggcag ggaccgggcg cgccggatcg catcggcgta cgactgggcg tccctgggcc
    12841 gcgtggtgga cgtcggcggc ggggacggca cgctcctggt cgcgctgctc accgcgcacc
    12901 cggggctccg ggccgtgctc gtcgagcggc cccccgccac cgacgcggcg cgaaaggcgc
    12961 tggccgcggc gggcgtcgcc gaccgcgccg aggtcgagac gggcgacatg ttcggcccgc
    13021 tcccgccggg ggccgggggc tatgtcctct ccctggtcgt ccacaactgg ggcgacgatc
    13081 cggcgcgcgc catcctggcc cgctgcgcgg aggccgcggg cacgggcggc tcggtgttcg
    13141 tcgtggagaa cgtcggtccg ggcggcgggc cgaccgggtt ggacctgcgg atgctcgcct
    13201 actgcggggg gaaggtgcgg tcgctgccgg agctgtccgc gctcgccgac gaggccgggc
    13261 tcagggtcgc ctccgtccat cccgccggag cggtttcgat cgtcgagctt caccccggca
    13321 ggtgacccgg gacacggcgg gccgcggcgg gccgaggaac cccgcgccgg cggcgacaac
    13381 gaggaatctc gcggaaggga cgagccgatg gccacgggga cgatgcagcc gcgtgaggcg
    13441 ctcgcggcgc tggtgggcga gggactccgg gatccgtatc ccctgtacga ggagatacgg
    13501 gcgcacggcg acctggtgaa gatcaaaccc ggggtgatgg ccgccgtcgg gtacgacgag
    13561 tgcgaccggg tgctgcggga tccgcggctg cgcgtccagg acggggagag cttcgacctc
    13621 ttctatccgg agtggcgggc gcactcctcg ctgcgcgcgt acaccgactc catgctctac
    13681 agcaatccgc ccgcgcacac ccgcctgcgg cggctgctgc ggggagagtt cacgccccgg
    13741 cgggtggcgg gctacgagac ggcgatcgag cagatcaccg accggctcct ggactcgctg
    13801 gcggaggcgg gcgcgggcgg cacggcggtc gacttcatcg ccgagttcgc ctcccggctc
    13861 ccgatcgcgg tgatcagcgg gctgctcggg gtgcccgagc gcgaccaggc gtggttccgg
    13921 gccatcgcgg ccgacgtcac gaccgccctc gaggggatca cgaacgcctc ccggctcgct
    13981 ccggcggaca cggccatgga cgacctggcc gtgtacttcg acgagctgat cgagcggcgt
    14041 cgccgctgtc ccgaggcgga cctcgtcagc tccctggtcc gggtgcacga cgacggaggc
    14101 gggctcggcc gcgacgagct ggtcggcaac atgatgctgc tcctgacggc cgggttcgag
    14161 acgacgaact tcttcatggc gcacgcgctc ctcctttcct tcgagcatcc cggcctcgcc
    14221 gaccgccttc gcgccgagcc cggcttcgcc tccgcctacg ccgaggaggt gctgcggttc
    14281 gagccgcccg tgcaggcgac gagccgctgg gccggggcgg acgtggagct gctggggacg
    14341 acgatcccgg cgggcacgaa ggtggtcgcc atcctggccg ccggcaaccg ggacccgcgc
    14401 cgctaccgcc ggcccgaccg cttcgacccg gaccggccct acaccgcgcc gctcaccttc
    14461 ggcgcaggcg gccacttctg cctcggagcg ccgctgtcgc gcctggaggc gcggatcgcg
    14521 cttccccggc tgctgcgccg cttccctcgc atccggctcg ccggagagcc cgcccgccgc
    14581 gactcatggg tgggccgcgg catcgaccac ttcccgatcg cgatcgacta gacggagccc
    14641 gcgccggatt ccgatccgcc ggcgtggggt cacggcctgg tccaggccgc ctcgcacgcg
    14701 gtgaggcgaa gcagccggaa gcccacggcg tcgccgagcc cgggctgctt ttcgaggcgc
    14761 atgagcagtt gggccagggc ttcgatccag cggctgccgg ggaggtcgcc cgcgtcggcg
    14821 acctcgagtc cgccggactc gacgatcgac cggaccgcct ctttcgcgcg gggatggtct
    14881 ccggcgatgg ggaccgtcag cgtgacgccg ttgtgcgcgg cgccggcgag ctgccgcgcg
    14941 gagaggcagt tgaacgcctt gaccacggcg ccgccgggaa gcaggcaggc gatcagctcg
    15001 gcggcggagc cgtggccgag gaggtcgtga ccgcccgggt tggacatgtc gatgaccggc
    15061 ttgccgacca cgtgggcgcg gatgcgcgga gcgatctcgg tgtggatggc ggcgagaggg
    15121 ctggccaggg ccacgatgtc ggcctcgcgg gccacccgtt ccaggctgcc ggcacgggcg
    15181 cccggcagcc gttcggcgag gccgctcgcg gagccgccgc ccctgctggc cagcagtaac
    15241 ggccgtcgct gcgccgcgaa ggtctcggcg agcgccgtgc ccatccgtcc gcagccgacg
    15301 atgccgatga ccggcgcgcg ggcctccggg accgcgccgg attcggagaa cctcatcgcg
    15361 gcggcgtctc cgatcgcggg cggcgggctc cgtgcgggtc gggcgcgtag gcgtcgaggg
    15421 ccgtccggag ttcgtcgggg acttcgacgg gcgtcaggcc gccctcctcc acccgcaccg
    15481 tgcaggagac ggtctgctcg ccgcgcgcca cgagccgggc cggcccgtcg gtggtccggt
    15541 agtactcgaa acccatggtg atctggtgga aatcgatggc gacgagggac atccgcaccg
    15601 agacggtgtc gagcgcatag agctcggaga agaactcgca cgagcacgac gaggtgacga
    15661 gcgcgaggtc gtcgttcagg cgcgccacgg tcttcggtgc cttctccgcg agaaacctct
    15721 cccggcaggc gccctgccag gacaggtagt tcgtgaagta gacgttcccc acgagattgg
    15781 tgtcggcgaa ggtcacgagg tgccggtatt cgaagtacgc cctcacgatg cccccttgac
    15841 ggggatcgcc atcgccatcg gcccggcttc gccttcgacg gaaaggacca cggagacgat
    15901 gtccgctccc ccggcctgga ggaccaccca tccgttctcg tagacccctt ggacggcgag
    15961 tccgggcggg cccggcggcc cggacaggca tgcgccgacc gtatgcaggc gtgtccggat
    16021 gtgccgttcc ggctcaccga cgaggcggcc gagccggtcg gcgagaccgg tccagtgcgt
    16081 ggggggttcc ggcgcggggt cggaggtccg cgcgcaggcg accggctccc cttccaccag
    16141 gacgtcccag ggtcggccgt tcgctcggcg accggcgttg aggtcgtggc ccggcccggc
    16201 tgcctcgacg accagccgga cgtcgcgctt cgggagcagg gcggtgaggg tgcgctgcag
    16261 gtagggcccg acgagcaccg gatgcagggt cgtgaccggc agcgggccga cgtcgcgaag
    16321 gcgaagcccg gtccagctca cgaccggccg gccggagccg tcgcgcacga ccacgtcgta
    16381 ggtgtggtcg gcgccggagt gctcgcgttc gacggcggcg agcgtcagct cacccccttc
    16441 ggccccgccc tggtggacgg cgaaccgcgc gcacccgacc ggcagcaggc gccgatgggg
    16501 gacgcatccc tggaggacgt ggatcgaggc gtcgttgcgt gcggggtcac cgaacaggag
    16561 gtccgccgga aggccctccc cgaaccgcca gggccggtcg ccgtccagca cggccgtgca
    16621 cgcggtggcc tccagctgag cgtagcggcg gagtctgcgg aagcgccggc cgtggaagaa
    16681 cagcggcccg tacatgtcgt caccggtgtg ggccggtacc cgcgccgtca cggccgggtt
    16741 ctccggtggc tccgcgtccg ccggggtgac ggtcccggtg aagtgatcga cggcgaagcc
    16801 cgtctcgtca ctgcgcaccg cgacgtccac gtccccgtcc tcgcggacga gcgcacatat
    16861 ccggacggta cgggtcccgt gctcggggac gaccacgggg cggtcgaagc gggaatccac
    16921 cacccccgcc acgggccggc cggtcagcgc ggccgccgcc tgggccatcg cttcgagcac
    16981 gcacaccgcg ggcagcacgg ccacaccgtc gatgcggtgg tcgtcgaggt aggggtcgcc
    17041 cggcaggctc agctcggcct cggccaccag ttcgacgccc ggggtccacg cgcgcacccg
    17101 ccgcaggaag cggtgcccgt ccagggccgc ctccccggcc tggccgagct gcggcagccg
    17161 cccgctgatc accatggaat gcgacggcgg ccgcgcctcg gccgcctgcg cgagcagctc
    17221 ggtcccccgg tcggggggca ccggcgccac gccggcgcgg gcgaggtcgt cgagcacctt
    17281 gaggcgctcg cccataccga ctcccgacca gaccgtccag tcgaggttgg cgacccggca
    17341 gcccggcaga tcccgggcga gggtccggac cagctcccgc atgcggccgt tggccagggc
    17401 atagtgcgcc tccccggcaa ggccgaagcg gccgatcacg gacccgaagg tgaggagcag
    17461 ccgcagcccc tccgcgtcga cggcgtccag cagcgcacgc agcccgtggt gcttgggcgc
    17521 cgcgtgctcg gcgtaggcgg cgccgatctc gctgaaccgc gccggacggt tcaggccact
    17581 ggcgtggatc actcctctga ccggtccgag ccggtcgacg atcgcggcga cgccgtggtg
    17641 gagcgactcc ggatcggtga cgtccgccgc ctcgtagcag aagtcgatgc cggcctcccc
    17701 cagccgggag aggttggcgc gcagctcggc gtcggcgtcc gccccgctgc gtccgatcag
    17761 ccccagccgc accccccagc gccgcgccag gaagtacgcg ctcgtgaagc cgatgccctt
    17821 cccgcctccg gtcaccacga gcacttcccc ggcggacagc gggggtccgg ccgcgtccgg
    17881 aaccggcccg gccggagcgc cggagccggc cgcccggtac gcgggggcgc gggtgcggcc
    17941 ctcctcgtcc acgacgatct cggcatgacc ctcccacgag gccgtgagca gcgcgccgac
    18001 cgcgtccgcg ggggcggccg ccagagcccg gacccagcgg accggcaggg aggggtactc
    18061 ggcggcgatc gtgcccacga agcccgacgc cgtgtccccc gagtccacga cggtgaaggg
    18121 cgcgccggtg tccaccgcga ggtgggcggc ttcgagcagc gcgtcgatcg cgccgtcgtc
    18181 cgggttctcg gggaggaacg cgacgaccgc cgggcgaggg tccccggagg agtcggctcg
    18241 ctcgtccccc tcggtgaggg cggtcaggcg gggctcgacg agcgcgcgca acctgccgtc
    18301 cccgaagacg tgccagacgc gggaccccgg ttcggcgtcc agctcgaccg gacgggcgta
    18361 ttcgaccagt acgcgatgcc agtcgcggac cccctccggc ggcccctgcg aaccggcctc
    18421 gccttccgcg gcgggcagtt cctcgatcgc ctgggcgaac gagccgaccg tggcctccgc
    18481 gaagagcggc ggggcggccg gtaccgcccg ccgggtccgt tcggcggcct cggcggcgag
    18541 ctggacgacg cgcagggagt tgagatggag gtcgccgagg agccggtccc cgtcgccgat
    18601 cacatcgggg ggaagctcca gggcgtcggc gatgaggccg cgcaccacgg agggcacgtc
    18661 ggagtccgct ccgggcggtg cctccgccgc gggcgccgcg gtatcggcgg cgaccggtcc
    18721 cgcggcgacc gccgcggaac ggccgaaccg acggtcgagg ccgtcggtcg gggcgctctc
    18781 gcaggggttg gcgaggaact ccggctcccg ccagaggtcg aacgggcggt ggaagcgttc
    18841 ggcgaagagc gccgtgaggt cggagacggc gccgacggcg aacagcgcgg cggtggcgtc
    18901 gccgagcgcg gcggccgacc cggcgcccgc gtccagcgtg cggaccggca cgtccgtgat
    18961 cgactgggcc atcgccgtga gggtgtggcc ggggccggcc tcgacgagca ggtcgcagtc
    19021 ggcggcgagg agctccagcg cctggcggaa ccgcacgggc gcggtgagct gccgggcgag
    19081 cagcgtgcgg atgtcgtcgg cggccgtcag ctcccggccg gtgaccgtgg agtacacgcg
    19141 accgggcagg gccgccaccg ccaggtccgc gaggtgccgc gcgagcaccg gctcggcggc
    19201 ggcgaccgcc ggggagtgga aggcgtggct gaccctcagc ctgccggcgg tgatcccctt
    19261 cgcgcgggcc ctcttcacga cgcggtcgac ctcggtgagg gggccggcga cgacttggac
    19321 ggcgccgttg tcagcggcga tcaccagatc ggcgtcgtcg atcagttcgg tgaccgtgcc
    19381 ggccggcgcg gcgagggagg ccatccccgt tcccgcctgg gaggtgtcgg ccatgatgcg
    19441 gccgcgcctg gtcaccaggt gcagggcgtc ctggcggctc agcgcgccgg cccagtgcag
    19501 ggcggtgatc tcgccgaggc tgtgcccgac cgccgcgtcc gccgtgaccc cgagccggtc
    19561 gagccagcgc agcgccgcgg tggaggcgcg gaagacggca ggctgggcga cggcggtgtc
    19621 gatcgggtcc gccgcgagcc cgtcctcgaa gtgctccccc gcctcgggga ggaccacgcc
    19681 gagggccccg gcgcgctccc gtacgggggc gccctgcccg gggaacagca gcccgacccg
    19741 ggccggagcg ccgcggccga cgtagatgcc gggccgggcg gcgaacccct gttcgccgag
    19801 cccggcgagg agctcgccgg cccgttccgc gcgcgcggag agctcggcgg ggtcgcgggc
    19861 gacgaccgcc gcccgcaccg gcgcgtcacc gtgcgcgcgc tccccgaggc cggcggccag
    19921 atcggcgtgc tcggcgagcg acatcgtcct cgcccgcacc gccacgcgct ccaggagggc
    19981 ggtgaggtcg gcgaccgtgt cggcggagag ggcgaagacc tcgcagtcga gcggctcccg
    20041 cgccgcccgg cggtcccggg ccgccaaccg cgccgtggtg cggcggacgc tcgcggcctc
    20101 caggacgacg tgggtgttga tgccgccgaa tcccatcgcg ctgacagcgg cccggagggg
    20161 agcgtccggc cagggctcgg cctcgcggac gatgcgcagc ggcgcgccgg ggtcgcgcag
    20221 gagcgggtgg ggctcatcgc agccggtggt cggcgggatg acctgacgct gcagcgccag
    20281 cgccgctttg atcagcccgg cggcgccggc ggccgccttc gtgtgcccga tgttggcctt
    20341 gatggatccg agcgccgccg gtcggggcct ccgccgtccg tcatggatct cggagagggc
    20401 gtgcagttcg gtgcggtcgc cgacctcggt gccggtgccg tggccctcga acagcgccac
    20461 ggtctccggt ccgaagcccg cgcgcgcgta ggcacgctcc agagcgagcc gctgcccgga
    20521 gacgtccggc cgggtcagcc cgccgttccc gtccgaggac atcccccagc ccctgatcag
    20581 ggcgatcggc cgctgcccgg cggcgacggc gtccccggcg cgcatcaggg cgaccatcga
    20641 gcagccctcg ccgggcagga agccggtggg ccgggcgtcg tacacccgca tcgccgagtc
    20701 ggccagcgca ccgagccggg agaacccgac cagctcgaac gggtcgaggc tgaggtcgac
    20761 accgcccgcg agcgcgaagt cgaggtcgcc gtcgcgcagg taggtgcagg cagtgatgac
    20821 ggcgagcagg gacgacgagc aggcgccgtc gaccgtgtag cccgcgccgc ggaagtcgaa
    20881 gtggttgcac acccggccgg cgatggcgtt ggccagcccg ccgacgaggc tctcgtcgtt
    20941 gggctcggcg aagggctcct tgtaggactc ctcgacctcc cgcagcaggc cgtccagttc
    21001 cgtggtcccc cagccgcgcg cggcgagggc ggacaccagg ttcctgcgga cgtagggcca
    21061 gcgcaaccgc atgagcgcgg cgcggctgaa ctcgcccgtc agggtgttcc cgaggatcac
    21121 gccggcgcgc cgccggtcca gcccgcgtcc cccggggaag ccggcggcgg tcagcgtgtc
    21181 gccggcgacg tccagggcga gccagtgcgc gaggtcggtc acgcggtacg ccggcccggg
    21241 cacccggtag cgcgagcggt cgaaggtcca gccgtcgagg acggccgcgt accgcagatc
    21301 ggtcgtgtcg ggaccgccgg ccgggtcgcc gtagtcgccg aggtcgaggc gctcacgcgg
    21361 gagcggccgg aaggcgcgcc gccgcgccag caccgtctcc cacaactgct ccggcgtgga
    21421 ggcgtcgggg tggcggcagc cgaggccgac gacggcgatc gcgtcgttct cgacggtcac
    21481 ttcgcctcct cgccggtcgc cagcacgcct ccgcgggcgg gcgccggccg cggcgcggtc
    21541 ttgggctcgg tcagcggcgc cggctgcgcg gtggcgcgct gccgcgcccc catgatcgcc
    21601 agggcggcgc cgcgcagcac gcacacgatg acgagcgcga agaacaggcc gtagaccacg
    21661 tggatgtgga ccaggaacgc gtacacgagg gcggtcgacg cgccgaagaa gaactggttg
    21721 cgcggccgca ccggtgtcgt ccccgggtca gtgatcatgt agttggtgaa caggacgaac
    21781 gccacgccgg tcatcgccag cagcgcgctg agcgtcgccg tgccctcgat gggcgtccgg
    21841 atcagcgcct ggagcgcgaa cacgccgatc cagccgagga tcaggggcat cttcctggtg
    21901 agcttggcgt tcagcatcgt cccggccgcg aggatgagcg ccgggatcgc cacgtcgagc
    21961 ggtccgccga cccactcggt gaactggtac ggaggcgcga tcccgaccca ggggaacagc
    22021 accaggacga ccgcgatgcc gaagttggag gggttcagca cgtgccgcgg ccgtcccttg
    22081 atccggaccc tgatcagata cttcgaggcg acggccacga tgaccgcgaa gatgaccggg
    22141 cccagccgcg cgttggcgta gaggagcatc gcgcaggcca gcgcggtgat gtgggcgggc
    22201 atcaggaagt tcatgaaggc gaccggcccg cccgcgtact tcaccggccg tcgcgtcgcc
    22261 caggcgtcca gggtctccag ccccagctcc atcacgtacg ccacggccat cgcggcgagc
    22321 ggggtcgccc acgacggctc gaacccgagg accgtgtgcc cgaggatgtt gaagaccgtg
    22381 atcgatatcg cgaaccggcg cagcgcgatg atccgcggat ccttggcggg tccgctcggg
    22441 gcggcggacg ccgggttggt cgtggattcc acgttcgccg agttcacgag gccatctccc
    22501 tgatcgaacc gtcgggcccg agcagcatgc tgtgccagcc cggagtcgcc tggaccttgc
    22561 cggtgtgccg ggtgccgcag gagtcgcgcc aggtgatcgt gacggggacc ggcgccgcgg
    22621 tcccgtccag cgcgaacagc agttccggcg aggacacgcc ggcatggccg ttggccggat
    22681 agacctggcc cgtccgctgg cccttggctc cggagtccag gacgacctgc gcgccgatcg
    22741 ccggtactcc ggcggagccg gccggtggcg tcgcggcgga accgccctgc cgcgtcccgc
    22801 atcccggcgg gctgaggagc ctcagcccga gatagggccg ctgcgcactg cggacgttgc
    22861 ggtagaagtg cgattgaccc cactggttcg cgacggcgaa gtcgagccgc ccgtcgtggt
    22921 ccacgtcggc gagcgcgatg ccccgcgacg cctggcggtc cgcgacgccg agccggccgg
    22981 cgacatcgtg gtaccggccg tccgagccgc gtacgaagaa cctgttggga ttgtcgccgg
    23041 aaatgtcgtc cttcttctgc acattcggcc acaggcgcgg gtgcgccagg acctcgtcgt
    23101 tggacatcgc cagctcctgc agctgggccc agcggttgtc cttcccctcg acgaatccgg
    23161 tggcctggac gatctggtcg cgcccctcgc ccgcgaagtc gccggccttg atgtcccagc
    23221 cccagcccga ccgggacagc cccagccgct cgctgtggtc gtcgtagtac gcgcgcccgt
    23281 ctgtccccac gaccttcttg cgggtgctca cccaggcgaa gttgctctcc aggagcccgt
    23341 actcctgggt gatgttgctg accacgatgt cgggcacgcc gtcgacgttg atgtcggtga
    23401 accccacgcc catgcccttg aaggagtccc tgcccagctg catcgacttc ggcgtggtga
    23461 ggtggcgcac gcccttgaga aggcggagct tgagcttccc tggcctggac tcgttggcga
    23521 gcagtcggtc ggggccgaaa tcgttggcga agtagagctc cggcaggccg tcgccgttga
    23581 ggtcctgcgc cccgatcgcc agtgtccagc ccttggcgac ctcctcggag aagagccggc
    23641 gctcctcgcc gtagaccgcc gagggacggg agccgccctc cgcggaccgg aaccgcagga
    23701 cccggttgac gccgccgttg attcccgcgg acatcgagcc ctgcatctgc agctcgctct
    23761 ggcgcgcggt cggatcgagg acccgcgcgc ggtccgggaa gtagttcccg accacgatgt
    23821 cggtgtggcc gtcaccgtcc agatcggcaa gcgacaccgc gttggtgttc cacacctggt
    23881 atgggcgcat cagttcctgt ggggcgaagg cctcgttctt gcccagcgcc gccggagtgc
    23941 gcaggaacag caccggcgat cggccccagt agtagacgag gacgtccatg cggccgtcct
    24001 cgttgaagtc gccgggcacg caccccatcg gcgccatcgt cctgtcgtag ggcaggccgt
    24061 gcggagccag gctcgtcgcc gggagacgtg acccggtgcc cggtacgggg cgcagcatga
    24121 cgctgtcgtc gcgcggatcg accaggcaga cctcgtccgc acggccgctg ccgtcgatgt
    24181 cggcgagcgc caccgcggcg ccgaccgacg agatccagtg gtcgatcccc ttgtaggccg
    24241 gggcgaccgt gcgtatgtcg cggggcgagg ccgtgccgtt cagcggctgc tgctggaacg
    24301 cgaaccggct cgcaaggcgt tcgttctccg cctgcgccac cgatggaagc cgggcgttgt
    24361 accagcccgc cacgatgagc agcgccgcgc agatcggggc cagccacacc cgaatccttc
    24421 tggtcatgcc ctcacccctc gttgtgcttc cgccacgcct gacgcaccct cgcgcgccac
    24481 acctcgtagc cctccggacc gctgccgcag cgctcggcgg tcaccgccgc ctcgtccgtc
    24541 cacgccgcgg cgaccgcggg ggcggctccg gccagcgtct cgatcgcggc cgccgaccgc
    24601 tccggcacct cctgcgactc cacgtgcgcc ttcgccgcga acgcggcgcc ctgggcgatg
    24661 tgctcctcga agcccgcggc ccggtccagc agctcaccca gccgctccgg ggtgagggcg
    24721 ccggtgtacg cggcggccag gccgatgccc gcccagacgt cggaccgacg ggcggccgga
    24781 aaggccccga tcgtctcggc cacctcgacc ggatcgccgc cggcgtaaaa ccacagcgcc
    24841 cggccgacac cctggtcccg gattgtccgc atatttcccc gcgccggccg ctcgacccag
    24901 tgccggacca acacccgtct ggacttgaag aaagcctgat ggaaccccca gccgtcccac
    24961 acaagccaac gcagcagtgg tcgcccaaag cgaatgcccg tccacggatg cacatgcgtg
    25021 cgcgcgtacg cccaaccgac cccgacatga atcaggtgga tgtaccgtgc gccgggccct
    25081 tcggccagcg cgcgtactct gcggccgccc gaaaacgtgc ccaggtccgc cagggcgacg
    25141 cccatggccg cgccttcgaa ggcgaatcca cgtagatcgt gcggcagcgc ctggaaatcc
    25201 aggctcgccg gatccgcacc gagggaggtg ttgaatccgg tggcgaagct ctgcaccacg
    25261 tccgccagcc gggcacgagc ctgcggatca cccggcggaa aacccaggcg ctcgacgtcg
    25321 agggtcttgg gatcgatttc gaggaagccg cgcaacggcg gcgtcagcag attccctaca
    25381 gcggccattc caaccccaca gtggcaatac tgaccggcgg cgttcggcca aagagtttct
    25441 tgccgtgctg gcgacgaccg ccatggccat cggtcagaac ggtctatggg gtaatcgcgg
    25501 ccgaaagatg acccgactgg cgccccatga acttccgcgc agcgcgctga gtggccttac
    25561 gcccttctac acatacactc gactcggcga aaagtcacgc ctcttcgtcg ttgcttccaa
    25621 cggctccgcc gacctggccc gcggcctggt cgagaatgac cacgatccat tccgccaggc
    25681 tgagctccat cgcttcggcg gcctcctgcc agcggagttg gcgctcagcg atcacgtcga
    25741 tgcggacagt ggcctcatcc ggcttcttgc tgtcgtcacc gttgcggatt tctcgcaggc
    25801 gctttctgag ctctcgtctc gtccatccga gttctgccgc ctgctgcagc cagtgctcct
    25861 ggtcggatgg cgggagcgcg gccacctccg cgtggtgctg gagactgagc tggtcccgcc
    25921 ggcgggacct cgggatgcgg cgcgcgatcc aagcgtagtt cttgagtgtc tggtagtcga
    25981 gcgacgtggc ctctatggcc atccgatacc ggttcgggta atgccgctct ccgtagatga
    26041 gccagtcgcc gagccaccag cgcgagcagt ccgagataag ggatatctgg cgtccgattc
    26101 gctgccacgt ctcgaaggga agtcgggggg gcaactccaa accgcttcgc cgcggcctcg
    26161 ccgattggtc gagcaccatt ctggccgcgg agacccgatt tgcctcttca atcggggacc
    26221 gatgaggcga tgtgtaacgt tgcccatttc cggagccgga cacgaatatc ctcccgaaca
    26281 gtcgcggtgc gctgcgtgtt gccgaatgag gtcagaggct ggagatgaat ttttcgacca
    26341 cggcttctgc ggatcccctt ggacgtggcg cacgcgaatt ccctggcaga cttaatttcg
    26401 gccccctccg gtcgcccacc accgtcggcc gccccccttc gatcacgcct aacgcccgtc
    26461 gcccgcccac ctccgatcgt ctccagccgt cggggtgagc agcaatgatg gtcatcgtca
    26521 aactatttca ccaggttgtc aatagggcga atcggttatt aacgccttgc caaggtgatc
    26581 tcaccgagat gcaccaggaa cattgacctt tcaagcgtgt ctcacgtgga agggtgagat
    26641 tcttatgacc ggcgacggcg gcacgacgcg cgagaggggc ggccggctcg gatcgacgac
    26701 ggattcggag gtcccgtttc caggggctcg cccgaccggc cctgtccggg caccggtcag
    26761 ttcgccgccc gtttcgcacg ggcggcggcg gcctccacga tcgccgacgc ccagtcgagc
    26821 tgcccgcgcg cccctggctc ctccagcgcg gcgcggtgca ggcgcggcca cagccccgcc
    26881 ctggtccacg cggtgaagcg ccggtgggcg gtgggcacgc tcacgccgaa ctcggccggc
    26941 agatgccgcc aggcgcaccc gctggtcagc acgtacacga tcgcggtgaa caccatccga
    27001 tcgttcaccg gcgccgtccc accgccctgc cgccgcggcg cgaactccgg gatcagaggg
    27061 ccgacgatct cccacagctc atccggcacc aaccggatcg caaggtccga caacacgaac
    27121 accgatcatg ccgcatccgt catccggcca catgagacat gctcttagta gtctcggaca
    27181 ggcgggctcg ggaagccgcg cggacggttc gcgtcggccc gaacagcgcg aagccacgct
    27241 atgaagttgt cccaccacaa aagatcagct caatggcgtt gggctctgcg tgatctcgct
    27301 catcgcgccc atgcgcgacg tctccgggaa actcgtgcgg tccgggcccg gctcctgcgc
    27361 ggccggcgcc gacggcaagg ccctcacgcc ggcgatcggg gcgcggacct gccccggcag
    27421 gcggcgccgg cgtcgtgccg gcccgcgatg gcgggaggcc gaccgcctcg ggacgagacc
    27481 gcgaaatccc ctgctcggcc gcctggcgcc atccaccggc cggcctcacc ggctgagaat
    27541 gcacaccatc accgaaaccg caccccgccg cttattccat gacgggcaaa gccgcccgca
    27601 taaagtcgcg gagatcacac cgccaggggt taccattcac agccggtcct gagggtcccg
    27661 cacgactccg atgggccccg gccctgcacc cggcacggtc acctctggcg ctcctgccgg
    27721 gacggcacct cagccggtcg cgccgctcgt gacgagaagg ccgtgcatca cgaaaggcgc
    27781 ggcctccaac tggaagtcca tcatcgggtg atggcgcttg accacaccct gcaacgtgag
    27841 caggcagagc atggggaata tgaactccgg ctcggcgtag aggcgatatt tccgctgcag
    27901 atcgaagaga tccaggcaga acgcggggag atcgaagtct cgggccacca taccgacatt
    27961 tcgcaggaca aggtcggata tctcagcgcg aaaggccgca atatccgttt ccgggtccgt
    28021 gcgccgcacc gttgacagca gaatgtcggc gcacacctcc ccgtctcctc ggatcatgcc
    28081 ggcgaagaag ccggtgaacc tctcccgcgc cctggggctc attcggaaga ccagaccggc
    28141 gtccaggagc acgacggtgc cgtcgggctt gaaataggtg ttcccctggt gcaggtcgag
    28201 gtggaggaaa ccctcgatga acagcatccg gtagacggcg tgcaccagcg aggtgatctg
    28261 cgcctcgcgg acccgcgcgg ggaggtcctc gatcacgccg cgatcgagac cctcgatgaa
    28321 ctccatcgcg atgaccccgt ccccgctcag ttcggggacg ggcctcggga cgacgacgcc
    28381 cggtatcccg gcgagatcgt cgtgcagccg ccgcaggttc gccgcctccg cgccgaagtc
    28441 gagctgggcc atgaggcagt cgccgacctg gtcgacgatc tccatgaacg gcacccgccg
    28501 gaaagccggg agccgtgcgg cggcaccggc ggcggcccgc agcacggcca tgtccgccgc
    28561 gatcgcggca cccgcgccgg ggcggcgcac cttcaccgcg agcacccggc ccccgcgctc
    28621 cgcgcggtac acgcaggcga tcgagccgcc ggccaccgac ggccccccga ccgcccgcac
    28681 gaactcgggt ggcgtcaggc cgagcccggc gcgcatggtc cgcagcgcct cctcgggggt
    28741 catcggctcc acgtcgtcat gcagcctgcc gagcgcggtc gcgagcgtct cccccacgag
    28801 gtccacgcgg gttccgagaa tctgcccggt tttcacgaac gccccgccca gccgttccat
    28861 gagacgcgcg agctcggcgg ccagccgcgt tccgcgagtg ccctcggacg aggtcgcggc
    28921 gatggccgcc atgcggaccg cggccgctcc gccgcacgcg cctatccgga ccgtccgcgc
    28981 cgccagagag cgggcactgg cacgatccac catcaggccg ccgttccgga gagcccgcgc
    29041 tcaagcgcct cccggagtcg tgcgggcccg gcgtcgaagg cctcctgcgg gacggggacc
    29101 ggctccccga cacggcggaa gtccgtccag ccaccggtcc gcgtgcggca ggccctgacc
    29161 cgctcgggca atccacccac gtccggacgg cccatctcca cgacctccca gcggcggaac
    29221 ggtatccgga gacgctcgac ggcacgcgcg acgaccaggc cggtctcgtg gtcgatcgcc
    29281 tcggtgacgg tgaggccggg cgtggtgacc ggtcccagat agcaccgcgg ctcggccgcg
    29341 ggccaccggc tccaggacat gtcgacctcg acgtcctcgg gagtggcgcc caaccccgga
    29401 tagcgccagg ccatgagatc caggtatccg atgtcggtca gtggaaggca gtcgaacagg
    29461 tagcgctcga ccaggcgaac cgaattcctc atcgtgggta tatgcgtttc cacttcgcat
    29521 tcaccgcgag cggagttctc ggttatccac acatgacttc cggcaaggat ctgcgggtgc
    29581 agaacgaata gggtggtcac cgccgagtgg tcggagaaac ggcggccgat caggtagcgc
    29641 atggggcgtc gaccgatcgc ggcttcgatg gcgaagccat atgatgtcag gccacccgcg
    29701 ctgaggttcg gacgcgccgg cctggtcatg cgcacatgct ccactgatgg caccttcccg
    29761 atgacggctg cgaccgctct tcgctttccg tcttatcggc gatcagagtg ggctgatggt
    29821 ttcatgtcga tggcgatcac gtagtgggct cattactctg cgccgaggtg taacgtctcg
    29881 tcatgtcgtc atggaaatag aggcgctcgc cgccagtaaa agctatcgtc gcgacggcgt
    29941 caagataaga cttccaactc cggcgcggtc ggcggcgcgg cgacggaaga tccgccgcag
    30001 aacgcggcac cgggggcgcg tccccggacg catgcggtat taccggcacg gggcatgcgg
    30061 ctatcgagat ctgcctttga aggccggaag ccggccgctg atactccccg ggcgggagtg
    30121 ctctctcagg ccaccaggcc gagcaggcgc gagcagcgga tgatcgcgtc ctcgtcgccc
    30181 tccatgacga tgcgcctcgt gagcgtcgcc tccagcgggt ccaggcgccc ggcaccgatg
    30241 tcgacgaagg tcaccgcgtc cgtgtggacg acgagcgccg gttcgacggt cgccttccca
    30301 tgggcgaccg acaccttgcc ctcgtggacc gtgatgtgga acacgtcgtc gtcgatgcgg
    30361 aactcgtact gctcgtcggg gccttccacg gtcggggccg ccatcgcctc caccgcgagc
    30421 accgcccacc tgggtcgcac gatgtactcg gccttgggct ccgtgagcac gccgagcccc
    30481 cagcgcgcga gcacgagcac cgcctcgcgc aggccctcgc cctgctccgt gagttcgtac
    30541 acccggactt tcgaaccttc gcggggccgc tgtcgaatga ttccgacctc ggtgaggaac
    30601 ttcaaccggt ccgccagcag gttggtcccc agaccgggca ggttggccag aagctcgttg
    30661 tagcggcagg gtccggtgag cagttcccgg atgatgagca gcgtccagcg ctcaccgacg
    30721 atgtccagcg cgccggcgag gccgcagtac tgtccgtagt tccgacgctg attcacgtac
    30781 ccgtaccgcc tcccaggttc actttagaag tgtataccca gttggccgcg catcgcggaa
    30841 cctcggccgt gcgggccggc gccttcgccg cgatggcccg gcccttccgg gaccgtcgcc
    30901 ggcccggcgc cgcgcgaggg ccgtcagctc tccgtcgcgg cccaggcctt cttcgcgttc
    30961 ttccatgtcg aggagttgac ctcctcccac gcgcggctgc gcaactcctc gaggacatgc
    31021 gacggcacca ccgttccgga catgttcgcc cggtagatgt tcatcgtgtc cgggtcgaag
    31081 tcgctccgga gatgcccctc cgagatcgcc gtgtcgaaca gcggcgtccc cgggagcggg
    31141 accacgatga agaagttcgc ggcgtcgaga ccgaaggaca catggtcgcg ggccaggttt
    31201 atcgtggtct ggatctcctc cagggtctcg tccgggtaac ccatcatgta gttaccgaag
    31261 atcttgaacc cgtagtcctt cagtgccacg atcagcgatt cgatgtcggc catctcgatg
    31321 ttcagcttgt tgctcgcgta cttgcgcagg atccggagat tgcccgactc gaacggcagg
    31381 ttgagctggg tgaacccggc ttcggccagg gcctccagca cctcgtgatc gggtttccac
    31441 cgcttgagga ggtggatgat gttgatgccg ttcagatcgc agatgttgac tccggcgccc
    31501 tggatcttcc gcagcagccg cagggcgcgc ttcttgttcc cgaggaggga gtcgtcctcg
    31561 atcatcacgt gctccacgcc cagccctttc aggacgtcca gttcccgcag cacgcgatcg
    31621 tccgacttgg cgcggtagcg cccgatgggg ccgctcatgc tcccctcctg ctctcccgct
    31681 atatggcagt aggcgcagtg gaacgggcag ccgagcgagg tcatcatgtc cgcgtagcgc
    31741 agctccgtac cggactccca cacgcccgag tgcggccggg cgagggtcca gtaccgctcg
    31801 ttcggcagca ggtcccaggc cggcatgggc agggtgtcca gatcccacac cacgtcgtcc
    31861 gggcgcgcgg ggttgacgcg gatctcaccg gagtccagga acgcgacgcc gctgatcgcc
    31921 gcgaagtccg gacgggccga cctgcgcacc tcgtcggcga tcttcgtgat cgtgccctcg
    31981 gcctcggaga ggcagacgac gtcgaaaccg gcccggaaga actgcggcag ccgcgaccgc
    32041 gcgttgaccc cgccggagac gaggaccttc tccgggaagg ccgcccggag gagtcgcgcg
    32101 cagtgcagga ccatcgtctc ctggtccgtg aagatcgagg tgatcccgac gatgtcgtac
    32161 gccgccgcct cttccaggat ccgctcgtcg ctgacgcccg tccggaggag gccgctcggc
    32221 agctgaccgg gcttgtcgaa gatcgcgtcg agcgagtcgg agtcgtcgcc gacgcacgcg
    32281 tcgaacaccc gcacgtcgac gccgtggtcg cgcagggcgc cgccgaggtt gggatacgcg
    32341 agcgatccgt tcggcttgca caccgtcccc ggggcggtct ggttcggcgg atacagaagc
    32401 aggacacgta catcacgcaa ggccatgtat gactcctcaa ccgacggcgt cccggtccgt
    32461 cccgcgttcc gccggcggac tcatcggtgc cgcccgccgc ggaggcgatc ctggggagga
    32521 gctccccggg cccgccgtgc cacctcactg tactatatgc ttctaaagtt aacaccgcgg
    32581 tggtgtccgt cttctctgga ggtacgtcga tgtcccacgg gtcctccccc gcctcgcagg
    32641 gccacgccct gacagagatc gaccggtccg ccgccccggt gtacgtccga tgggagcggc
    32701 agctcccggg gctgatggac cggctcggcg tggcaccggt gggagtggtg caggtcgggg
    32761 cacatatcgg acaggaagtg ccggcgctcg tccggtgcgg tttccggcgg ctcgtcatgg
    32821 tggagcccaa ccgcgaccac tccgcggcgc tcgcccgcga gctcgggcgc cacctgtccg
    32881 gccggccgga gccggagggg ggccggcccg cccaggaggt cgtcctggca gcggcggggc
    32941 gagagcgcgg aacggccacc ctgcacgtca cggagtacga ccagcaggcc agcctgctcg
    33001 cgccgctgcc gccgatgacg gtgaccaggc tggacaccac cgaggtcgtt ccggtgcgcg
    33061 aggtccagca cggctgcaac gtgctcgtgg tggacgccca gggcgcggaa ctggacgtgc
    33121 tggcgggcgc ggacctggac cggctggacc tggccgtgat cgagggcagc gcggaggccc
    33181 gttaccactg cggggcgacc cggcaggccg tcgcggccta catgcaggac cgcggctggc
    33241 ggctggtggc gaactggacc cacgcgcgcg ccaacgtcgc cgacatggcc tggctggccc
    33301 cctcgaccag cctccgtgcg acgtaccgcg ccgaccgggg ctgaaggcgg ccccgcgatg
    33361 cgactgtcac gatcggcgcg gcatgcacgt cagtgagacg gccgttcccg gggcctacgt
    33421 cttcacctcc gaccacaact ccgaccggcg gggcgacttc ttcgaggtca tgcgcgccga
    33481 cgtcctcgac gtcacgctgg ggcgcccttt cgtaccgcgt cagatcaact gttcgacgtc
    33541 gcggcgcaac acgctccgcg gcatccgcag cgtcaccgtc ccgcccggtc aggccaagta
    33601 cgtcacctgc gtcagcggcg cggtgcgcga catcgtggtc gatctgcggg tcggttcccc
    33661 ggcgttcggg caccacgcgg tcaacgagct gtacgccggg tcgggccgaa gcgtctacat
    33721 ccccgaaggc gccggccacg cctttctggc gctcaccgac gacacctgca tctgctacgc
    33781 cctgtccagc acctacacgc ctgacgccca gatctccatc aacccgctgg atcccgacct
    33841 cgcgcttccc tgggggatca cggagccgcc gctgctgtcc gacggggacg cggcggcgcc
    33901 caccatggcc gaaaccatct ccgccgggct cctgtcccct tggcaggagg ccgacgctcc
    33961 ttctacgcgc ctgcgaggaa gcaaccgatg aaagctctgg tgctgtcggg tggatcggga
    34021 atgcggctgc gtcctttcag ccactccatg gccaagcaga tgatgccgat cgccaacaag
    34081 ccggttctgg agtacgtcct tctcaacatc cgcgccctcg gtgtcacgga gatcggcatc
    34141 atcgtcggcg accgggccca ggagatcatc gatttcgcgg gcgacggttc ccggttcggc
    34201 gcgcgggtga cctacatcca ccaggacagg ccgctcggtc tcgcgcactg cgtgatcttg
    34261 gctcgctcct tcctggccga cgacgacttc gtgatgtacc tgggcgacaa catgctgccc
    34321 cacggagtcg cggacgtcgc cctggacttc gccgcgcagc gccccgacgc ccaggtgctg
    34381 gtgcacaagg tggcggaccc gcgcgccttc ggggtggtgg agctggacgt cgaaggccgg
    34441 gtcgagcgcc tggtggagaa gccggaggac ccccggagcg atctcggact gatcggggtg
    34501 tacttcttca ccccggccat ccatgaggcg gtggcctcga tcgagccgag cgcgcgcggg
    34561 gagcttgaga tcacggacgc cgtccagtgg ctgctggccc ggggcgcgga cgtgcgggcc
    34621 agcgagtacg ccggctactg gaaggacacc ggccgcgcgg aggacgtcct ggactgcaac
    34681 cgccggctcc tggaaacgct gcagccctgc atcgccggtg acgtcgacgc gcactgcgag
    34741 atcgacggcg cggtcgtggt cgaggccgga gcgcggatcg tgcgctcccg catccagggc
    34801 cccgtgatcg tcggtgcggg ctcggtcatc gaggacagcc acatcggtcc ccgcacgtcg
    34861 atcggccggg gctgcgtcct gcggcgcacc ggcgtgaccg gctccatcgt cctcgacaac
    34921 gcgtccatct ccggtttcgc cgggctgcac gactcgatca tcggccgcaa cgccagcgtg
    34981 agcgcctcgg cccggccccg gctggtcgtc ggtgacgaca cgcgggtcga ggttccggca
    35041 tagcccggcc ggtgcgcccg ggcccgggcg ttctcctcag cccgggcgtc gtcctcaggt
    35101 ccgggccgct gaccgccggg ccctcgcctc gagccaggcg tcgtgggcgc cccggacctt
    35161 cgtccacagc gcggtccgct cctgcggacc cacgtccgcc agcgggagat cgaagacctc
    35221 ggcgagcgcg ccgtaccact ccgtgaaggt accgagctcc ctggtcgtcc tgccggagtc
    35281 gtcgacgtgc cgcagcatgc atcccgtcag gctgtcgacg ctcgtcgcgt cgcgccgcat
    35341 caccgcgacg gtccgcacca ggcgcgattc gggatcggtc gccaggtagg ggtgccactc
    35401 ggcgaagtcc gccggaccgg cgggctccat cgagaagtcg agcccggcga tcgcgccgcc
    35461 gtcgtcgtgc tcgaagcgcc agccgccgga cccgaaccgc gaggggccga gatggaaggt
    35521 gaagggtcct tggcggtacg ccccggcacg cagcggcagc ggctcgtgca gcccgtcgcc
    35581 gaggccgacg tccaccatcc aggccccgcc ctcgacgctc acggtgagca ccaggtgcgg
    35641 ggccggttcg gccggcccga ccggcggcag cttccggccg gcgtgaacgc cggcccggtg
    35701 ccacgtgacg tcgtatccga gcgccgtcag cagagtggag aacgcgccgt tgagctgcac
    35761 gcagtacccg ccgcgcccct tcagcacctg accggccgcg taacgcgggt ccgcggtggt
    35821 cggccgtccc aactggatct ccagcacctc gtacggcacc cgctccacat gggcccggtg
    35881 cagggcgaat agtccggaga gcgacggctc gcccgggtcg ccgatgccga gacgttccag
    35941 gtactcggcg acgtaccggg agccgcccgg ctcctctggg acgggcgcgg aacccgatgt
    36001 gtgctggcca ggcatgaccc tccgtccgga ccgggtgcgg tcgcgccacc gctccaccga
    36061 tgctacttca aattaaagta gcacagcctg cctctccccc tcgggagggg cgcggcggcc
    36121 cgttcgccgc tacccgcggc cgcgccgcga gtacgcgtac gccgtgagcg gcgcgaagac
    36181 cgcgacgagg atcgcgcagg ccaggaacgc ccggcccatc tggcccgcgg tctcggtgcc
    36241 ctgcatcagc ccgcgcacgg ccgtcgccgc gtgcgtgatc gggttgaccc cgatgacggt
    36301 ctgcagccac gacggcatgg tctcgcgcgg cgcgatgatg ttgctgccga acagcaggac
    36361 cgagtccagc gtgatgatga gcatctgcgc cgacgccgcc tggcgcaccg ccaccccgac
    36421 cagggcccag atccaggcga ggctgaaggc gaacacctgg aggaacagca gcgccagcac
    36481 cacgccggcc ggcccgccgt ccgggc
//
