LOCUS       NZ_BMRD01000024        28661 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence24, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000024
VERSION     NZ_BMRD01000024.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 109900)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 28661
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000024.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28661
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="oligosaccharide"
                     /region_number="1"
                     /rules="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /tool="antismash"
     cand_cluster    1..28661
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /kind="single"
                     /product="oligosaccharide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28661
                     /aStool="rule-based-clusters"
                     /category="saccharide"
                     /contig_edge="True"
                     /core_location="[1654:18661](+)"
                     /cutoff="20000"
                     /detection_rule="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /neighbourhood="10000"
                     /product="oligosaccharide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1655..18661
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /neighbourhood="10000"
                     /product="oligosaccharide"
                     /protocluster_number="1"
     gene            complement(<1..385)
                     /locus_tag="IEZ14_RS36510"
     CDS             complement(<1..385)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS36510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="ABC transporter permease"
                     /protein_id="WP_189269973.1"
                     /transl_table=11
                     /translation="MTTSQPMTRAREPLAARGERPPRAGALSASMTFGWRALLKIKHSP
                     NQLADALMLPVIFTLSFTYLVGGAIAGSPGRYLHFFLPGVMVMAVALTTAYTGIVLNQD
                     IDQGVFDRVRSLPVWQSSVLVGAM"
     gene            complement(399..1406)
                     /locus_tag="IEZ14_RS36515"
                     /old_locus_tag="GCM10010177_73660"
     CDS             complement(399..1406)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851124.1"
                     /locus_tag="IEZ14_RS36515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73660"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_179834697.1"
                     /transl_table=11
                     /translation="MGSNSTLAVETSGLVRTFGETRAVNGVDLAVPTGIVHSLLGPNGA
                     GKTTFLRILTTLLRPTEGTARVLGHDVVREADAVRSRVSVTGQSTSIDEDLTGRENLAM
                     VGRLLGHRGAAARQRADDLVDAFELSEVADRPVKTCSGGERRRIDIAASIIITPDLLFL
                     DEPTTGLDPRARNQVWDIIRTLVAGGTTVLLTTQYLDEADRLSDRVAVLDHGKVIAEDA
                     PGKLKSQVGTGALKLRLQDPGQRAQAEEMLSRMLSVEPGADTDPHRLSVRIADAQQAAR
                     AVTALGDAGIALDDFSMAQSSLDDVFLALTGHPVADDGRAEKDEAKDDDTQTAK"
     gene            1655..2893
                     /locus_tag="IEZ14_RS36520"
                     /old_locus_tag="GCM10010177_73670"
     CDS             1655..2893
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01426.2"
                     /locus_tag="IEZ14_RS36520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73670"
                     /product="macrolide family glycosyltransferase"
                     /protein_id="WP_179834698.1"
                     /sec_met_domain="MGT (E-value: 3.3e-39, bitscore: 127.9,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPRHILFAVTGGTGHIRPTFGVLDELSARGYEISFVTSGDYFDD
                     LAEVGARQIRHRSIFEDGVDLPEMVEQEDAEALTVSAFINENLAMLRAAESALDENPPD
                     LVVYDIFPLIAGRLLAARWQRPAVCINGGFASNEHYSVWEALSAVHGHRPIVETGTFQR
                     MISELLPEYGIDRSPTEFWNAIEDLNVIFLPRSFQVESDTFDDRFVFVGPSFSQGRLQP
                     GWRPPDEDRDVLLVSLGSTFNGHPEFFRSCAQAFAGTRWHVVIATGNGTDPKALEPLPP
                     NVEAHQYISFMEVLRHAKAFILQGTLGATMEAVHWGCPMLYFTEYAVEARPFAERSVEL
                     GLGHVLRPEQVEGGGLVSAVENLVADGAVRRRISRMRTEARDAGGAARAAEVIDSYARR
                     VVSRPGGAFGAVR"
     misc_feature    1665..1680
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.53"
                     /tool="antismash"
     gene            2949..4001
                     /locus_tag="IEZ14_RS36525"
                     /old_locus_tag="GCM10010177_73680"
     CDS             2949..4001
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (65-189). E-value:
                     6.6e-13. Score: 40.3. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS36525_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017533186.1"
                     /locus_tag="IEZ14_RS36525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73680"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_179834699.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.3e-17, bitscore:
                     56.5, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5.3e-11,
                     bitscore: 34.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.1e-12, bitscore:
                     40.3, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVVVTGGCGFIGSHLVERLAHQGEDVIVYDPAAPPPDLDCGGTA
                     VRHVRADIRDERALAGAIGPDVHTVYHLCALVGVDQYLDDPLEVIDVAVSGTRNVLRAA
                     SAAGVKVVVSSTSEIYGKNPDVPWSEDADRVLGSVTADRWSYSASKAVAEHMVVAYARH
                     RGLRASVVRYFNVYGPRQRPAYVISKTVHRVLRGLPPLLYDDGTQTRCFTFVEDAVDAT
                     LRVGAGETADGQCFNVGSDRETSVGDAVRLVTRLAGAEFAPIRVSTDSALGSAYEDIPR
                     RVPDVGKARELLGWRSRTPLQAGLARTIAWAKRSPWWLDAVAGASERSLVPTGVTTAAD
                     GRKVRGHDIG"
     CDS_motif       2955..3020
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS36525_0001"
                     /evalue="8.00E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="IEZ14_RS36525"
                     /protein_end="24"
                     /protein_start="2"
                     /score="8.9"
                     /tool="antismash"
                     /translation="VVVTGGCGFIGSHLVERLAHQG"
     aSDomain        3144..3515
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS36525_NAD_binding_4.1"
                     /evalue="6.60E-13"
                     /label="IEZ14_RS36525_NAD_binding_4.1"
                     /locus_tag="IEZ14_RS36525"
                     /protein_end="189"
                     /protein_start="65"
                     /score="40.3"
                     /tool="antismash"
                     /translation="DVHTVYHLCALVGVDQYLDDPLEVIDVAVSGTRNVLRAASAAGVK
                     VVVSSTSEIYGKNPDVPWSEDADRVLGSVTADRWSYSASKAVAEHMVVAYARHRGLRAS
                     VVRYFNVYGPRQRPAYVISK"
     gene            3988..4644
                     /locus_tag="IEZ14_RS36530"
                     /old_locus_tag="GCM10010177_73690"
     CDS             3988..4644
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077873.1"
                     /locus_tag="IEZ14_RS36530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73690"
                     /product="hypothetical protein"
                     /protein_id="WP_179834700.1"
                     /transl_table=11
                     /translation="MTSGETAATAAGTGALPAPAAYMCGLTWDGARLWHSDQDAKKIFA
                     IDPATGGVSRTLACDRVRADLAYDGARLCQVGGRPKRIVLIDPDDGRITGEKEVLPASG
                     RLTGIDLGPEGMYMCLRGPTVVQLRDYDTMTVLREFPAEGESPSGLTYADGVVVYGDFD
                     DAVLRAMDPRTGEHLGALPVPGRPTGLTWDGRRLWYCDFPARAIRPLELSAVLSA"
     gene            complement(4670..5341)
                     /locus_tag="IEZ14_RS36535"
                     /old_locus_tag="GCM10010177_73700"
     CDS             complement(4670..5341)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020539726.1"
                     /locus_tag="IEZ14_RS36535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73700"
                     /product="DNA alkylation repair protein"
                     /protein_id="WP_179834701.1"
                     /transl_table=11
                     /translation="MAETAVAEVMAELAELEDPKAREVNEKRGDDHGVNLSKLRALAKR
                     LKTQQDLARELWKTDDSSARLLATLICRPKAFERDELDAMLRGARTPKVQNWLVNYVVK
                     KSPHSEELRLAWLDDADPAIAGAGWALTTERVMRKPDGLDLDKLLDIIEAEMKAAPERL
                     QWAMNDCLGNIGIKHEEHRARAIEIGERLEVLKDYPTPPNCTSPFVPIWINEVVGRKKS
                     K"
     misc_feature    complement(5396..5410)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.22"
                     /tool="antismash"
     misc_feature    5479..5495
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.09"
                     /tool="antismash"
     gene            5683..6384
                     /locus_tag="IEZ14_RS36540"
                     /old_locus_tag="GCM10010177_73710"
     CDS             5683..6384
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017771.5"
                     /locus_tag="IEZ14_RS36540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73710"
                     /product="DUF899 family protein"
                     /protein_id="WP_179834702.1"
                     /transl_table=11
                     /translation="MSDDEPEIPPMWPVGTSQEYIDARIELAKAERLLRDRVEEVAAAR
                     RRMPGGAVLGDYTLTEGPADLEKDEPTGSVSLRDLFGDHETLVVYHLMYHPDDQAACPM
                     CSMWVDGFNGVAAHLAQHTAFAVVGKAPLPMLRAWARRRGWDEVRILSSHGTAFNADMH
                     AERPDGAQRPMISVLAREDGRVRHFYTLPADFLDGAQRGIDLLSPVWNVLDLLPGGRGD
                     WYAGNAYAGRD"
     misc_feature    6442..6451
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.58"
                     /tool="antismash"
     misc_feature    6444..6453
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.58"
                     /tool="antismash"
     gene            6479..7702
                     /locus_tag="IEZ14_RS36545"
                     /old_locus_tag="GCM10010177_73720"
     CDS             6479..7702
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009072609.1"
                     /locus_tag="IEZ14_RS36545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73720"
                     /product="cytochrome P450"
                     /protein_id="WP_179834703.1"
                     /sec_met_domain="p450 (E-value: 6.3e-24, bitscore: 77.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTQPAAAAGAFPVPRACPFSLPPEYERLRTGRRAVRARMAGGNS
                     AWLVARHEDARKVLSDPRMSVDRRREGFPRFAPVTEEERQASFRAFRPPMNWMDPPEHT
                     AARRSVRAEFSPARTEALRPRVQEIVDRRLDLMADAPRPVDLVRELAAPVPSLVICELL
                     GVPYSVHGHFEERTGRMFSHATPAAERTRAAHEIRSLLAELVADKEREPPDDLLGRLIV
                     RGRREGAADREAVVSMAFVLLVAGHSTTADMIALGVLTLLEHPDQLASMVADPARTPLA
                     VDELLRYLTVVNASTARTALADVEVGGVTVRAGEGVVVLGPAANRDPEVFERPDEFDVG
                     RGGGRHLAFGAGRHRCLGHRLARMELQIVFDALFRRFPGLRLAVPFGALSFKEKANIYG
                     VRELPVTW"
     misc_feature    7748..7764
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.53"
                     /tool="antismash"
     misc_feature    complement(7758..7774)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.87"
                     /tool="antismash"
     gene            7855..8988
                     /locus_tag="IEZ14_RS36550"
                     /old_locus_tag="GCM10010177_73740"
     CDS             7855..8988
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF044385.2"
                     /locus_tag="IEZ14_RS36550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73740"
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /protein_id="WP_179834704.1"
                     /sec_met_domain="MGT (E-value: 2.1e-103, bitscore: 339.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVMFCSHPGLGHFFPLVHLAWAFRTAGHEVIATIAGPTEGAAGS
                     GVEIVDAAPGFSMEAVNERLAREHPEFVQTVATKPAINLDEWGPGFAAINRPLIDGLVA
                     LADDWGPDLVVYDQGTTAGLFAAARAGAPAVQRNVSAWRTRGMHEAAAAHLPDVCERYG
                     VSISKPAVTIEEFPPSMLAGEQPEGWFMRWLPHSGGSVIGDRLPRPPERPRIAVSMGTV
                     ELQMLGTGTMRTIIDAAADVDAEFVLALGGVDIGSLGPLPDNVSSVGWIPLHFLLGTCT
                     AIVHHGGGGTALTAIDAGIPQLITPDPRDLFQHTTLEAVRKRGIGFVSEREDVDAGLLT
                     RLMTDEGVRAATAEVQREMATLPTPAATVQRLIEHLF"
     misc_feature    complement(7864..7880)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    7879..7894
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.58"
                     /tool="antismash"
     gene            complement(9073..10341)
                     /locus_tag="IEZ14_RS36555"
                     /old_locus_tag="GCM10010177_73750"
     CDS             complement(9073..10341)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077855.1"
                     /locus_tag="IEZ14_RS36555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73750"
                     /product="hypothetical protein"
                     /protein_id="WP_218935143.1"
                     /transl_table=11
                     /translation="MHEEVVTEYLSLGLRFGRLADGFVDSWYGDPELARRVEAEPRPDA
                     SGLAARSARLLAALPDSGLAEPRRRFLSAQLAALNCAARRMAGEEIPFGDEVRTYFEVD
                     IELGEPDRYAEIHDAIGALLPGSGDLRARTAAFYERNAVPPDRLARAVQAVSGELRAMT
                     RTVFDLPEQESVEYVVVRDKPWNAYNRYLGGFRSRVELNAEAGRTIAALPLLAIHESYP
                     GHHTEHCRKEAGLVDGAGHGEHLISLVNTPQCLMAEGTAEMADAAVPGPGWGRWTADIL
                     ADAGVRVEGELVEEVLRLIRLLMPARQDAAIMLHDRGADPDQVTGYLERWLLVPPDHAR
                     RMTRFLTDPLWRAYSVTYIEGPRLVGAWLNAGPGRTSLVERYQRLLDEPLLPSDLRADL
                     EAVGREEPRPEPETVPADTAAEA"
     gene            complement(10380..12140)
                     /locus_tag="IEZ14_RS36560"
                     /old_locus_tag="GCM10010177_73760"
     CDS             complement(10380..12140)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012706.5"
                     /locus_tag="IEZ14_RS36560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73760"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_179834705.1"
                     /transl_table=11
                     /translation="MTVSDRPQAAPWSEDLPRPGGTLRLHGPAPVHRLDPSASHQAPAD
                     QLIRLFARQLFGYAPAPDLRDWRAIAPAPDLATDVPSTYNTGMGARHTNYVVHLRRGVF
                     WDTAPAREVTAHDVVRGLKRLANPLTRPAALPYFTSTIRGMAQYCEDYAAAIRRDDPAA
                     EELAAFQNSHDIPGVLVLDDESLVIELMRPAIDFAAIMALPCASPAPVEYDAFLPGSPE
                     LHRNLRSNGPYRPVHLVPGRELRLEPNPAWRQESDPLRHRYLDGVEVTVEDAAPERVAA
                     RVASGAADLPWGVRVAEPHDAEPADPGDGLGLALDPYLVFNVQSPTAGGALADARVRRA
                     LSYAIDKAAIADLHRRSGGGALVRIAGSVVPPGNDAHQELDLYATPGGRGDARKCRALL
                     AEAGHGSGLALTAVHLDTDLDAAVARSYAADLEKAGVTVRLVALDHDARDALLGDPGRA
                     AEGAWDVAAASWSPDWHPNNGRVFLQPMFQSSDSRNSANHGRYRRPEVDRLIERALTTI
                     EEPARSTAAWNLAERTVLEDAAVVPILFQRPAVPRLRGPRVRGAIPMPALGHAYDLAGV
                     WLDPPDDPAG"
     gene            complement(12137..13474)
                     /locus_tag="IEZ14_RS36565"
                     /old_locus_tag="GCM10010177_73770"
     CDS             complement(12137..13474)
                     /NRPS_PKS="Domain: Aminotran_5 (80-347). E-value: 2.1e-38.
                     Score: 124.1. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS36565_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077865.1"
                     /locus_tag="IEZ14_RS36565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73770"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_218935144.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.8e-34, bitscore:
                     111.3, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.9e-06,
                     bitscore: 20.0, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQSVKPDERSVPDPAGPANGGSPRRLRDAPWESIRELFALDPTT
                     THLNTGTVGAMPYEVLDTIDRVTREWTGGLADVYKPSGYYEHRAAIGRAFGVDQDEIVI
                     CHNATEGVARIIQGLDLHEGDEVVTTSHECYSVLSNFNLVRNRYGLTIKTLTMPTGYDV
                     TADEIVDLFEAAITPRTKVLAFAGITLFTGTMMPMRRLCELAQRHGLTTVIDGALLPGL
                     VNLDMRALGADFIACSGSKFQCGPLGTGILYLRNKVFPEYNPLPLPTFWPVISTWYPMI
                     GSPPPRTRTSVESDDTALYVQSAGSASIARGAALARACEIWDEIGRDRIERRAMELGDH
                     ARRRLVEAFGKESIFSPGEDPLLKSPLIAFNPFRDPEAAWNIKKFTAFTDRLEREHRIW
                     IRWTEFDVPGSPHQHYAARVCTHLFNTREEIDRAIGIMARLGEEMS"
     aSDomain        complement(12434..13234)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS36565_Aminotran_5.1"
                     /evalue="2.10E-38"
                     /label="IEZ14_RS36565_Aminotran_5.1"
                     /locus_tag="IEZ14_RS36565"
                     /protein_end="347"
                     /protein_start="80"
                     /score="124.1"
                     /tool="antismash"
                     /translation="PSGYYEHRAAIGRAFGVDQDEIVICHNATEGVARIIQGLDLHEGD
                     EVVTTSHECYSVLSNFNLVRNRYGLTIKTLTMPTGYDVTADEIVDLFEAAITPRTKVLA
                     FAGITLFTGTMMPMRRLCELAQRHGLTTVIDGALLPGLVNLDMRALGADFIACSGSKFQ
                     CGPLGTGILYLRNKVFPEYNPLPLPTFWPVISTWYPMIGSPPPRTRTSVESDDTALYVQ
                     SAGSASIARGAALARACEIWDEIGRDRIERRAMELGDHARRRLVE"
     misc_feature    complement(13505..13522)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    13507..13523
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.98"
                     /tool="antismash"
     gene            13818..15512
                     /locus_tag="IEZ14_RS36570"
                     /old_locus_tag="GCM10010177_73780"
     CDS             13818..15512
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077867.1"
                     /locus_tag="IEZ14_RS36570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73780"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_229810671.1"
                     /transl_table=11
                     /translation="MEPRYGGTLRYFGPGGMDHVDPACAYYAFSHQIIRLFARQLFGYP
                     TAVDETALTPVPDVAAESPTIANGGMSPDGLVYRIRLRPGVMWDTDPPREVTAEDFVRG
                     FKRMCNPVAGAGAIAYYTSTIKGMAEFAEGYRREFAGRAPSAADLAGYQNAHEISGLRA
                     DGDRTLVVELVRPANDLLNLLSMMFASAAPREYDAFVPDSAEFIANIRSNGPYRLTGYE
                     NGSHLTMERNPVWRQDTDPLRHQYVDGLDVRMARVDDDRVREAIRSGEADLSWGAPVIS
                     EDRRPPDADRHLGYAMNPYLVFNLKTPNEGGALRDVRVRRAVAYAVDKASMVRLLDDMD
                     LGTVTQTAHTAIPPGNFGHREYDRYPTPGDHGDPAKARALLAEAGYPDGLTLRVLYRAD
                     APHADIARYYAADLEKAGFTVELRLISQPDEYYRFLQNPAMAEAGEWDITAAAWTPDWF
                     GNNGRAYVQPMFQSNFAAGTSNYGGYRNPEVDRLIEEALSEPDPARAEELWHRIDRQVI
                     EDVAIVPVLACEPTIPHMTSARVRNGLPLPQVDRWLDAACIWLDPPD"
     gene            complement(15528..16532)
                     /locus_tag="IEZ14_RS36575"
                     /old_locus_tag="GCM10010177_73790"
     CDS             complement(15528..16532)
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000007: Methylation (62% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013087.5"
                     /locus_tag="IEZ14_RS36575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73790"
                     /product="methyltransferase"
                     /protein_id="WP_179834707.1"
                     /transl_table=11
                     /translation="MDAQQSALFLFEEAMAFAYSAALRAAAELGVADHLADGPRTTAEL
                     AAATGTGQGALYRILRLLAARGVVHEDRPGRFRLTARGDALRADAPMSARAGILMFTDR
                     MFWTVTHEAATVARDEATTFEQLFGTTIGGYFAENADIEALFYDGMATVSEAENALVAG
                     SYAFPSSGTVVDVGGGKGGFLRAVLRRNPGLHGVLLDQEEHVLGHHLLGGDDIAGRWQI
                     TDGDFFASVPSGDVYLIKRILHNWDDEKCVAILRNCRRAMKPDGRVLAVDAIIPAGNAA
                     HQSKPMDFMMLAARTGQERTEAELHPLFEAAGLRLARVLPTASVMSIAEGVPR"
     misc_feature    16588..16606
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.24"
                     /tool="antismash"
     misc_feature    complement(16589..16607)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.2"
                     /tool="antismash"
     gene            16667..17419
                     /locus_tag="IEZ14_RS36580"
                     /old_locus_tag="GCM10010177_73800"
     CDS             16667..17419
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="IEZ14_RS36580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73800"
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_179834708.1"
                     /transl_table=11
                     /translation="MSYGAAHAELYDPVFRSRGKDFEAEAEGLNRLVRSRSPKARSLLD
                     VACGTGAHLENLARYFDHVEGIDHSPAMRDVARGRLPGVAVHSGDMRDFELHRTFDVVI
                     CMGSGLAEAESPEQMADSVARMSAHVAPGGVLIVEPWYFPDNFLDGHAAGHLFRENGQV
                     ISRMTHSARHGDTSRVEIRFVIVDSSGFREFTEVIVKYLLPREGYEAAFERAGCTVEFV
                     PGFSLADGRPNSPGLLVGVRAGGTDRTG"
     gene            17462..18661
                     /locus_tag="IEZ14_RS36585"
                     /old_locus_tag="GCM10010177_73810"
     CDS             17462..18661
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01426.2"
                     /locus_tag="IEZ14_RS36585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73810"
                     /product="macrolide family glycosyltransferase"
                     /protein_id="WP_179834709.1"
                     /sec_met_domain="MGT (E-value: 1e-44, bitscore: 146.0,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSAAAHRIALVNVANHGSVLPTLPVVSELVRRGHDVGYVTSPEY
                     AGLVERTGAKVVPYASGAAGAAEAFADDDPARPHLLYLAENEAILRAAHAHYAEDAPDL
                     VLYGEVPIIAGQVLAAAWKRPACRINPGFASNHAYSYSREMIEETGGVDERTQGVVNAR
                     LGALLAEYGLRDRAGEFADRVEDLNLVFVPREFQIAADTFDERFAFVGRSAAHEERPGT
                     WRPPEDGSPVVLISLGTTFNDHPDFYRQCAEAFESTPWHVVMALGDRVGAGDLGPLPPN
                     VEAHRWVSLPAVLEHARLLVTHGGIGAVMDALIVGRPMVVVPFTFDVKPMARRVGELGL
                     GTVIPAAEFTGVRLREAVEELADDRATLERVRRMREHTARAGGAARAADVIEGYLARRR
                     "
     misc_feature    complement(18681..18694)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.66"
                     /tool="antismash"
     misc_feature    complement(18682..18695)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.44"
                     /tool="antismash"
     misc_feature    18684..18697
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.57"
                     /tool="antismash"
     misc_feature    complement(18687..18696)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.42"
                     /tool="antismash"
     gene            18741..19889
                     /locus_tag="IEZ14_RS36590"
                     /old_locus_tag="GCM10010177_73820"
     CDS             18741..19889
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013227.5"
                     /locus_tag="IEZ14_RS36590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73820"
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="WP_179834710.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 4.2e-75,
                     bitscore: 245.9, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPLFKVAMAPDALGRISEVLDSGRLEHGPKMVEFEEALALRLGN
                     PRVLAVNCGTSGLHLALSMVADPDRFPATAQPSGDAGGPGEVLSTPLTFEATNWPILAH
                     GLRVRWVDVDPATLTIDLDDLAAKISPATRAIVVVHWLGYPVDLNRLREIVDRAEEAYG
                     FRPVVIEDCAQAWGATYRGAPLGNHGNVCVYSFGAIKILTCGSGGLIVLPDEDLHRRAR
                     LRRWLGIERQADRVHGDYDVAEWGYRFPMNDISAAIGLSNLEIVDGLLARTRKNAAFYD
                     KELSGIAGVEHTERADDREPSFWAYPLKVADRTSFMRKMADAGIMTSMISRRNDAHSCV
                     AVAREGLPGLDGVHDRVVYVPVGWWLSEEERGHIADTIRSGW"
     gene            complement(19923..20198)
                     /locus_tag="IEZ14_RS36595"
                     /old_locus_tag="GCM10010177_73830"
     CDS             complement(19923..20198)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014636.5"
                     /locus_tag="IEZ14_RS36595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73830"
                     /product="MoaD/ThiS family protein"
                     /protein_id="WP_179834711.1"
                     /transl_table=11
                     /translation="MPHLIVPGSWHNVTSGKVRSELPAANLRELLETFVSSHPEAGYRL
                     YSPAGDLLPYHLFLVDGEQVPRATPPGDVALAPGSRVEIIPPLAGG"
     gene            complement(20208..21116)
                     /locus_tag="IEZ14_RS36600"
                     /old_locus_tag="GCM10010177_73840"
     CDS             complement(20208..21116)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1226: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077921.1"
                     /locus_tag="IEZ14_RS36600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73840"
                     /product="SUMF1/EgtB/PvdO family nonheme iron enzyme"
                     /protein_id="WP_218935145.1"
                     /transl_table=11
                     /translation="MADHETAMRGGVEAEDSVLIEGAAFRLGSPEWVLDWLAEQDQPFP
                     TPWFRDETPQTLVEVAPFVIDRYPVTSGRYAAFAEATGYRTVAERRGWSLVYGADYWQG
                     TPGASWRRPGGQDTGYVPPDDHPAVHIAVEDAEAFAAWAGGRLPTEAEWELAARGPEYR
                     LWPWGDEWSRELTNTTELRLGDATRTATEWRAWWKELQSDQGPIPLTTPVGSFSPHGDS
                     PYGVSDMAGNVYEWTASPSRLYGPSPDCDESLLTVMDRFRVIRGGSWMNLRFQARTSER
                     LHGDPTGWACFASGFRCVRDP"
     misc_feature    complement(21131..21146)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.97"
                     /tool="antismash"
     misc_feature    21154..21172
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 22.45"
                     /tool="antismash"
     misc_feature    complement(21155..21173)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.81"
                     /tool="antismash"
     misc_feature    21158..21174
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.88"
                     /tool="antismash"
     gene            complement(21198..22550)
                     /locus_tag="IEZ14_RS36605"
                     /old_locus_tag="GCM10010177_73850"
     CDS             complement(21198..22550)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152: nucleotide sugar dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019609407.1"
                     /locus_tag="IEZ14_RS36605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73850"
                     /product="nucleotide sugar dehydrogenase"
                     /protein_id="WP_179834712.1"
                     /transl_table=11
                     /translation="MEFLSDSPSPRIAILGFGYIGSCIGVALAERGMSVIGIDSDASMI
                     AGLRAGRCAIPEPGLAEALAPLVASARLACTTDYDALREADVVLITVGTPVDGNGALLT
                     AQLEEVCRQLAPRLRAGQLVILKSTVAPGTTRTLVVPLLESGGLVEGRDFGLAYCPERL
                     AEGDALAQVRELTVIVGGCGPGSTAAAARFWKAALDVPVRIVPTADIAEIVKLANNWWI
                     DANVAMANELARFCALFEVDVMEVIAAANSLPKGDGRVNILRPGAGVGGPCLTKDPWMT
                     WRTARDRGVRLRTVETARHVNDAMPEYAYEVIRDGLAKLGKDLASARIAVLGAAFKNDT
                     GDLRNTPVRGVVQALQAAGAEVRVFDPLADKERIRSEVGGSPVDDLEQAVRGADSVAFL
                     AGHRQFRHIDLERLRRQVAMPCLIFDGRMHYRAETIRRLRDLGFGYRGIGR"
     misc_feature    complement(22536..22549)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.02"
                     /tool="antismash"
     misc_feature    22649..22665
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.04"
                     /tool="antismash"
     misc_feature    22774..22791
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.2"
                     /tool="antismash"
     gene            22832..23626
                     /locus_tag="IEZ14_RS36610"
                     /old_locus_tag="GCM10010177_73860"
     CDS             22832..23626
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077875.1"
                     /locus_tag="IEZ14_RS36610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73860"
                     /product="hypothetical protein"
                     /protein_id="WP_218935146.1"
                     /transl_table=11
                     /translation="MTEERPAGVDLSSLAQRHVDQWAPTGGRSPSIARLARTAVRLDED
                     YCRAVAAYYDRAPRRGGDAGLRRRYDRLKRQNLRQFRSIVEAGIEIAPWLGEGQPYKGS
                     RHLRESVHRTGRLHVYLTSSGHGPSPAAGDHPLSGPSGVVVDGVEFCHNDLFRAVHDIF
                     GHVMLGNGFGPKGEFLAAFCHMHTYSRDVHPILFTEQIGQICWFFYGPHLLDGAGGLPG
                     PGDPGYLPPARRPYPEQKVFAFPVRFLDAFTSLFQPERSPDD"
     gene            23619..24926
                     /locus_tag="IEZ14_RS36615"
                     /old_locus_tag="GCM10010177_73870"
     CDS             23619..24926
                     /NRPS_PKS="Domain: Aminotran_5 (41-412). E-value: 9e-132.
                     Score: 431.4. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS36615_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077877.1"
                     /locus_tag="IEZ14_RS36615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73870"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_179834714.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.4e-132, bitscore:
                     434.7, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2e-08, bitscore:
                     26.5, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVMPQGGGSPVRLADQAFLPRSIRDDFPILATAQGGEPLVYLD
                     NAATAQKPQAVLDALVDYYSTANSNVGRGYYRLSMASTDRYEEARETVRQALGAEHADE
                     IVFTRGTTDAVNLIADGLGARLVGEGDQVVVTGMEHNSNLLPWRRLCERAGAELVVAPV
                     DERGAVDAAAFAAVLGPRVRIAAVAHVSNVLGTVNPVREMIAEAHRRGVPVVVDGAQAV
                     PHAPVDVRGLDADLYCFSGHKAYGPMGTGVLYGKRDLLAELPPYQVGGGTVKGVSHTEP
                     VRYVPVPARFEAGTPNVAGAVGLAAALRYVRDLGWDAVRRHDEALVRHAVESLRQIDGV
                     RVVGDPAAAPSGIVSFVVDGIHPYDVGGHLDRHGVAVRSGVHCASTFLDEMGLLGTVRM
                     SFAVYNTADEIDVVADALRSVRPGSWTTDHPTTRFL"
     aSDomain        23742..24854
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS36615_Aminotran_5.1"
                     /evalue="9.00E-132"
                     /label="IEZ14_RS36615_Aminotran_5.1"
                     /locus_tag="IEZ14_RS36615"
                     /protein_end="412"
                     /protein_start="41"
                     /score="431.4"
                     /tool="antismash"
                     /translation="VYLDNAATAQKPQAVLDALVDYYSTANSNVGRGYYRLSMASTDRY
                     EEARETVRQALGAEHADEIVFTRGTTDAVNLIADGLGARLVGEGDQVVVTGMEHNSNLL
                     PWRRLCERAGAELVVAPVDERGAVDAAAFAAVLGPRVRIAAVAHVSNVLGTVNPVREMI
                     AEAHRRGVPVVVDGAQAVPHAPVDVRGLDADLYCFSGHKAYGPMGTGVLYGKRDLLAEL
                     PPYQVGGGTVKGVSHTEPVRYVPVPARFEAGTPNVAGAVGLAAALRYVRDLGWDAVRRH
                     DEALVRHAVESLRQIDGVRVVGDPAAAPSGIVSFVVDGIHPYDVGGHLDRHGVAVRSGV
                     HCASTFLDEMGLLGTVRMSFAVYNTADEIDV"
     gene            24928..26046
                     /locus_tag="IEZ14_RS36620"
                     /old_locus_tag="GCM10010177_73880"
     CDS             24928..26046
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017542040.1"
                     /locus_tag="IEZ14_RS36620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73880"
                     /product="PLP-dependent aspartate aminotransferase family
                     protein"
                     /protein_id="WP_179834715.1"
                     /transl_table=11
                     /translation="MRFDTRLVHLGQESDGVTGDVVPPVHVAATFERRVQDPLRYFYSR
                     GENPTREALERCLAGLEDARFALAFSSGQAAGTTALSLLRAGRRLIASDDVYGGTRSLF
                     ALLGRYGITVDHVDLTDAGALDAALGDDVDMIWVEAPTNPLLKVADLSVVCERARRAGA
                     RVVVDNTLAGPALQQPLRFGADITLYSTTKSIAGHSDVIGGALVYDDEDLHRELASHRT
                     TTGGVPGGLDCFLVHRGLKTLSLRVARQVGNAEAIAAALRGCERVGAVHYPGLPEHPQH
                     EVAARQMSAPGSILSFEYLGDPEKLLDRVRLYACAVSLGGVRSLIECPAMMTHASVPRE
                     VRGRLGISDDLIRVSAGIEDPADLVRDLMDAL"
     misc_feature    24948..24962
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            26066..27019
                     /locus_tag="IEZ14_RS36625"
                     /old_locus_tag="GCM10010177_73890"
     CDS             26066..27019
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077881.1"
                     /locus_tag="IEZ14_RS36625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73890"
                     /product="homocysteine S-methyltransferase family protein"
                     /protein_id="WP_179834716.1"
                     /transl_table=11
                     /translation="MNDLSGGRRSGGEGPLRLDGGTATELQRAGMSVDGPWWTNRAMNS
                     EADRTRLRGIHQGYLGAGAQVITANTFRCNLRALSRLGLFDAGLAWMVHAAVGVAQSAV
                     RAGEEGRADGRGEADRTLIAGSVGPVEDCYRPDLVPPDDELRAEHRWLVTELMRVGVDL
                     VVIETMNSEREARIALEEALRAGARAWVGFVCDADARLLSGEKLTEAAGAVEREGAEAV
                     LVNCTAPADSETALRALRDACSGPIGAYPNIEDRNGIPRSAHVDRHVPAALGPDEFADL
                     IARWDAEFSLDVVGGCCGTTPDHLAAAHERLLGSGR"
     gene            27057..28055
                     /gene="rfbB"
                     /locus_tag="IEZ14_RS36630"
                     /old_locus_tag="GCM10010177_73900"
     CDS             27057..28055
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009225 - nucleotide-sugar metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-183). E-value: 1.2e-20.
                     Score: 65.6. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS36630_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009072808.1"
                     /locus_tag="IEZ14_RS36630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_73900"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_179834717.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.6e-21, bitscore:
                     69.3, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5.3e-20,
                     bitscore: 64.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2e-20, bitscore:
                     65.6, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGAGFVGSHYVRRLLDPERAGGGAHQVTVLDKLTYAGNL
                     ANLDPVRRAHGFAFVHGDVADAAVVDELVAGHDAIVHFAAESHVDRSIRCAQDFVVTNV
                     LGTQTLLEAARRHGTAPFVHVSTDEVYGPIGTGRWSERDPLAPSNPYAASKAAADLIVL
                     ACHRTFGMDVRITRGSNTYGPYQFPEKIVPLFVTELLDGGKVPLYGDGLHVREWLHVDD
                     HCRAVHLALTRGRAGEVYNIGGVPLTNRELTGRLLAQCGAGWDTVSYVEDRKGHDRRYA
                     MDCTKTATELGFRPRRDLVAGLAETVAWYRDNREWWEPLTLHVSRDVEVNS"
     aSDomain        27069..27605
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS36630_NAD_binding_4.1"
                     /evalue="1.20E-20"
                     /label="IEZ14_RS36630_NAD_binding_4.1"
                     /locus_tag="IEZ14_RS36630"
                     /protein_end="183"
                     /protein_start="4"
                     /score="65.6"
                     /tool="antismash"
                     /translation="VTGGAGFVGSHYVRRLLDPERAGGGAHQVTVLDKLTYAGNLANLD
                     PVRRAHGFAFVHGDVADAAVVDELVAGHDAIVHFAAESHVDRSIRCAQDFVVTNVLGTQ
                     TLLEAARRHGTAPFVHVSTDEVYGPIGTGRWSERDPLAPSNPYAASKAAADLIVLACHR
                     TFGMDVRITRGSNTYG"
ORIGIN
        1 gcatcgcccc gaccagcacc gacgactgcc acaccggcag cgaccgcacc cggtcgaaga
       61 ccccctggtc gatgtcctgg ttcagcacga tgccggtgta cgccgtcgtc agggccaccg
      121 ccatgaccat gacgccgggc aggaagaagt gcaggtagcg gccgggcgac ccggcgatcg
      181 ccccgcccac caggtaggtg aacgagagcg tgaagatgac cgggagcatg agggcgtccg
      241 cgagctggtt cggtgagtgc ttgatcttca gcagcgcgcg ccacccgaac gtcatcgacg
      301 ccgagagcgc gccggccctc ggcggccgct cgccgcgcgc cgccagcggc tcccgcgcac
      361 gcgtcatcgg ctgggacgtc gtcatctcgc ccacctcctc acttcgccgt ctgcgtgtcg
      421 tcgtccttgg cctcgtcctt ctccgctcgc ccgtcgtcgg cgaccgggtg accggtcagg
      481 gcgaggaaga cgtcgtccaa gctcgactgg gccatcgaga agtcgtcgag ggcgatcccc
      541 gcgtcgccca gtgccgtgac cgcccgtgcc gcctgctggg cgtcggcgat ccgcaccgac
      601 agcctgtgcg gatcggtgtc cgcgccgggc tccacgctca gcatgcggga gagcatctcc
      661 tccgcctgcg cgcgctggcc gggatcctgg agccgcagct tcagcgcgcc cgtgccgacc
      721 tgggacttca gcttcccggg cgcgtcctcg gcgatgacct tgccgtggtc caggaccgcg
      781 acccggtcgg agagccggtc ggcctcgtcg aggtactgcg tcgtgagcag cacggtcgtg
      841 cccccggcga ccagggtgcg gatgatgtcc cacacctggt tgcgggcccg cgggtcgagg
      901 cccgtggtcg gctcgtccag gaagagcagg tccggggtga tgatgatgct ggcggcgatg
      961 tcgatccggc gccgctcgcc gccggagcag gtcttcaccg ggcggtccgc cacctccgac
     1021 agttcgaagg cgtcgaccag gtcgtcggcc cgctgccgcg ccgcggcccc ccgatgcccg
     1081 agcagccgcc ccaccatcgc gaggttctcc ctcccggtga ggtcctcgtc gatcgaggtg
     1141 gactgccccg tgacgctcac gcgggaccgc accgcgtcgg cctcccgcac cacatcgtgg
     1201 ccgagcactc tggccgtgcc ctccgtcggg cgcagcagcg tcgtcaggat ccggaggaac
     1261 gtggtcttgc cggcgccgtt cggccccagc aggctgtgaa cgatgccggt ggggacggcc
     1321 agatcgacgc cgttcaccgc ccgggtctcg ccgaaggtcc tgaccagccc ggacgtctcg
     1381 acggccaggg tcgaattcga tcccacggtt gtgcctcccg tcgccaccag aagatcaagc
     1441 tcatcctaaa gtagcagctt atataagtca acgtctaagc agtccggcga gcggcgtgcc
     1501 gtccggccgg caggcccgcc cggctccccg gtccgggacc tccccaccgc gcggcgggcg
     1561 gcgggagatg tcgatgatca ctctcttgct aacttgaaaa aaccatagta gtgtccgttt
     1621 tcatggctct tctcgcttgg ttcggggaat cgtgatgcga ccacgccaca ttcttttcgc
     1681 cgtcaccggc gggaccggtc atatccgccc gaccttcggc gtcctcgacg aactctccgc
     1741 ccgcggatac gaaatcagtt tcgtgacttc cggcgactat ttcgacgacc tggcggaggt
     1801 cggggcccgg cagatccgcc accgatcgat attcgaggac ggtgtcgacc tgccggagat
     1861 ggtcgagcag gaggacgccg aggcgctgac ggtgagcgcg ttcatcaacg agaacctcgc
     1921 gatgctcagg gcggcggaga gcgctctgga cgagaacccg ccggacctgg tcgtctacga
     1981 catcttcccc ttgatcgccg gacgcctgct ggccgccagg tggcagcggc ccgccgtgtg
     2041 catcaacgga ggcttcgcgt cgaacgagca ctattcggtg tgggaggcgc tgagcgcggt
     2101 gcacgggcac cggccgatag tcgagaccgg gaccttccag cggatgatct ccgagcttct
     2161 cccggagtat ggcatcgacc ggtccccgac ggagttctgg aacgcgatcg aggacctcaa
     2221 cgtcatcttc ctgccgcgat cattccaggt ggagagcgac accttcgacg accgtttcgt
     2281 gttcgtcggg ccgagcttct cgcaagggcg gctccagccg ggatggcgcc cacccgacga
     2341 ggaccgcgac gtgcttctcg tttccctggg atcgacgttc aacgggcatc cggaattctt
     2401 ccgcagctgc gcgcaggcat tcgcgggcac gcgctggcat gtcgtcatag cgacggggaa
     2461 cggcaccgac ccgaaagcac tcgagccgtt gccgcccaac gtcgaggctc accagtacat
     2521 ctcgttcatg gaggtcctcc gccacgcgaa ggcgttcatc cttcagggca ctctcggcgc
     2581 caccatggag gccgtccact ggggctgccc gatgctctac ttcaccgagt acgcggtcga
     2641 ggccaggccg ttcgcggagc ggtccgtcga actcggcctg ggccatgtgc tccggcccga
     2701 gcaggtcgag gggggaggcc tcgtctcggc ggtggagaac ctggtcgccg acggcgccgt
     2761 ccgccggcgg atctcccgga tgcgcaccga ggcccgcgac gccggcggcg ccgccagagc
     2821 ggcggaagtg atcgattcgt acgcgcggcg ggtcgtgtcc cggccgggcg gcgcgttcgg
     2881 cgccgtccgc tgacagggcg atggtcgcct cgttgaagaa ggccatggcg gggaagggcg
     2941 ggtaaccgat ggcggtcgtg gtcaccggcg gttgcggctt catcggcagc cacctcgtgg
     3001 aacgcctcgc gcaccagggc gaggacgtca tcgtctacga tcccgcggcg ccgccgcccg
     3061 acctggactg cggcgggacc gccgtccgcc acgtcagggc cgacatccgc gacgagcggg
     3121 cgctggccgg cgccatcggc ccggacgtgc acaccgtcta ccacctctgc gcgctggtcg
     3181 gggtcgacca gtacctcgac gacccgctcg aagtgatcga cgtcgcggtc tccggcaccc
     3241 gcaacgtgct gcgcgcggcg tccgccgccg gcgtgaaggt cgtagtctcc agcaccagcg
     3301 agatctacgg caagaacccc gacgtcccct ggtcggagga cgcggaccgg gtgctgggca
     3361 gcgtcaccgc cgaccggtgg tcctactccg cgagcaaggc cgtcgccgag cacatggtcg
     3421 tcgcctacgc ccgccatcgg ggcctgcgcg cctcggtcgt gcgctacttc aacgtctacg
     3481 ggccgcggca gcgcccggcg tacgtgatca gcaagaccgt tcaccgggtg ctgcgcgggc
     3541 tgcccccgct gctctacgac gacggcaccc agacgcgctg cttcaccttc gtcgaggacg
     3601 cggtggacgc cacgttgcgg gtgggcgccg gtgagaccgc cgacggccag tgcttcaacg
     3661 tcggaagcga ccgggagacc tccgtgggcg acgcggtccg gctggtgacc cggctggccg
     3721 gggcggagtt cgccccgatc cgcgtgagca cggactcggc gctgggcagt gcttacgagg
     3781 acattccccg gcgcgtcccg gatgtcggga aggccaggga actgctcggc tggcgcagcc
     3841 gtaccccgct gcaagccgga ctcgccagga cgatcgcttg ggcgaagagg agcccgtggt
     3901 ggctggacgc cgtcgcgggc gcgtccgagc ggtcgctggt acccacaggc gtcacgacgg
     3961 ccgcggacgg ccggaaagtg aggggacatg acatcgggtg agacggcggc gacggccgcc
     4021 ggcaccggcg ccctgcccgc cccggccgcc tacatgtgcg gcctgacctg ggatggcgcc
     4081 cggttgtggc attcggacca ggacgcgaag aagatcttcg cgatcgaccc ggcgaccggc
     4141 ggggtgagca ggacgctcgc ctgcgacagg gtgcgggcgg acctggccta cgacggcgcc
     4201 cgcctgtgcc aggtcggcgg ccgcccgaag cggatcgtcc tgatcgatcc cgacgacggc
     4261 cggatcaccg gggagaagga ggtgctcccc gcgagcggcc ggctgaccgg gatcgacctc
     4321 gggccggagg gcatgtacat gtgcctgcgc ggtccgaccg tggtgcaact ccgggactac
     4381 gacacgatga ccgttctgcg ggagttcccg gcggagggcg agtcgccctc cgggctcacc
     4441 tacgccgacg gcgtcgtcgt ctacggcgac ttcgacgacg ccgtgctccg tgcgatggat
     4501 ccgaggaccg gggagcacct gggggccctg cccgtcccgg gccgccccac cgggctgacg
     4561 tgggacggcc gccgcctctg gtactgcgac ttccccgcgc gcgccatccg ccctctggaa
     4621 ctgtcggcgg tcctctccgc ctgacgaggt cccgccgcgc gcggacctcc tacttgctct
     4681 tcttccggcc caccacttcg ttgatccaga tcggcacgaa cggagacgtg cagttcgggg
     4741 gagtggggta gtccttgagc acctcaaggc gctcgccgat ctcgatcgcg cgggcgcggt
     4801 gctcctcgtg tttgatcccg atgttgccca ggcagtcgtt catcgcccac tgcaggcgct
     4861 ccggcgcggc cttcatctcc gcctcgatga tgtcgagcag cttgtcgagg tcgaggccgt
     4921 cgggcttgcg catcacgcgc tcggtggtca gcgcccagcc ggcgccggcg atcgccggat
     4981 ccgcgtcgtc gagccacgcc aggcgcagtt cttcggagtg ggggctcttc ttcaccacgt
     5041 agttcacgag ccagttctgc accttggggg tgcgcgcccc gcgcagcatg gcgtccagtt
     5101 cgtcgcgctc gaacgccttc gggcggcaga tcagcgtcgc cagcagcctc gccgaactgt
     5161 catcggtctt ccacagctcg cgcgcgaggt cctgctgcgt cttcagccgt ttcgcgagcg
     5221 cccgcagctt gctgaggttc acgccgtggt cgtcaccgcg cttctcgttc acctcgcgtg
     5281 ccttggggtc ctccagttcg gccagctcgg ccatcacctc ggccaccgcc gtctcggcca
     5341 tctcagcctc ctgtgcctcg cattacgagg gtctgagaat ataggcttag ttgacaattg
     5401 tcgcaatatc gagcttaaca tgaggcgcgt ttccattcaa ctctcccggt cttcgccggg
     5461 agggctttcg ccttgtttat gcgaaccagt tgctatgctg cggatggcgg cgtatcggcc
     5521 gatctcaccc tgtattcgag ggcgccgaga tcgtcgacgc cgaccgtcct ccctggccgc
     5581 cacgccgccg gacagggcga acccggcacg tcggcgggtt cattatcgta gagtccgatg
     5641 tcgaattgac ccttgccgcc tacggactcg aaggggccag cgatgagcga cgacgagccg
     5701 gagatcccgc cgatgtggcc cgtggggacg agccaggagt acatcgacgc gcggatcgaa
     5761 ctggcgaagg ccgaaaggct gctgcgcgac cgggtcgagg aggtcgcggc ggcgcggcgc
     5821 cggatgcccg ggggcgcggt gctcggtgac tacaccctca ccgagggccc ggcggacctg
     5881 gagaaggacg agccgaccgg gtcggtctcc ctccgcgacc tgttcggcga ccacgagacc
     5941 ctggtcgtct accacctcat gtaccacccc gacgaccagg cggcctgccc gatgtgctcg
     6001 atgtgggtgg acggcttcaa cggggtcgcc gcgcacctgg cgcagcacac cgccttcgcg
     6061 gtcgtcggca aggcgccact gccgatgctg cgcgcctggg cgcggcgaag ggggtgggac
     6121 gaggtacgca tcctgtccag tcacggcacg gccttcaacg ccgacatgca cgccgagcgc
     6181 ccggacgggg cgcagcggcc catgatcagc gtcctggccc gcgaggacgg gcgggtacgc
     6241 cacttctaca cgctgccggc cgacttcctc gacggcgccc agcgcggcat cgacctgctc
     6301 tccccggtct ggaacgtgct cgacctgctg cccggcggcc gcggcgactg gtacgccgga
     6361 aacgcgtacg ccgggcgcga ctgaggcccc ggccgtccgc agggcgatcc gggcacacgc
     6421 ccgccccggg tcagttcggt atatattttt atagtaccga gctgacacgg gggtcacgat
     6481 gacgacgcaa cccgcggccg ccgccggcgc cttccccgtt ccgcgcgcgt gcccgttcag
     6541 cctgcctccg gagtacgagc gcctgcgaac gggcaggcgc gcggtccgcg cccgcatggc
     6601 cggggggaac tcggcgtggc tggtcgcgcg gcacgaggac gcgcggaagg tcctcagtga
     6661 tccgaggatg agcgtcgatc gccgtcgcga ggggttcccc cggttcgccc cggtcaccga
     6721 ggaggagcgg caggcgtcct tccgcgcctt ccggccgccg atgaactgga tggacccgcc
     6781 cgagcacacg gccgcccggc ggtccgtccg cgccgagttc tcacccgccc ggaccgaggc
     6841 gctgcgcccg cgcgtccagg agatcgtcga ccggcggctg gacctgatgg cggacgcccc
     6901 gcgcccggtc gacctggtgc gcgaactcgc ggccccggtg ccgtcgctgg tgatctgcga
     6961 gctcctcggc gtgccctact ccgtgcacgg ccacttcgag gagcgcaccg ggcggatgtt
     7021 cagccacgcc accccggccg cggagcgcac ccgggcggcg cacgagatcc ggtccctgct
     7081 ggccgaactg gtggccgaca aggagcgcga gcctcccgac gacctcctcg ggcgcctcat
     7141 cgtccggggg cggcgggagg gcgcggccga tcgcgaggcg gtcgtgagca tggcgttcgt
     7201 gctgctcgtc gccgggcact ccaccaccgc cgacatgatc gcgctcggcg tcctgaccct
     7261 gctcgaacat ccggaccagc tcgcgtcgat ggtcgccgac cccgccagga cgccgctcgc
     7321 cgtcgacgag ctgctgcggt acctgacggt cgtcaacgcc tcgaccgcgc ggacggcgct
     7381 ggcggacgtc gaggtgggcg gcgtcacggt gcgcgcgggg gagggcgtgg tcgtgctggg
     7441 cccggccgcc aaccgcgacc cggaggtgtt cgagcgcccg gacgagttcg acgtcgggcg
     7501 cggcggcggg cggcacctgg cgttcggcgc cggccggcac cggtgcctcg ggcaccgcct
     7561 cgcgaggatg gagttgcaga tcgtgttcga cgccctcttc cgccgcttcc cgggcctgcg
     7621 gctggcggtc ccgttcggcg cgctgtcgtt caaggagaag gcgaacatct acggggtgcg
     7681 cgagctcccg gtcacctggt gaggcgccac cgcctccgca ccgccgcgga tattgaacga
     7741 aggaagatcg tagtttaagt tcatatagta acgtccgtat gccgcgatgc ccgaaccgag
     7801 gtgccgtccg gttccgtcgc ggcgagggtg cggggaagaa gggatcttcc ggatatgcgt
     7861 gtgatgttct gttctcaccc aggtcttggc cacttcttcc cgctcgttca cctcgcctgg
     7921 gcgttccgca cggcgggcca tgaggtgatc gccacgatcg cggggcccac cgagggcgcg
     7981 gcgggctcag gggtggagat cgtcgacgcc gcgcccggct tcagcatgga ggccgtcaac
     8041 gagcggctgg cccgcgagca cccggagttc gtccagacgg tcgcgaccaa gccggcgatc
     8101 aacctcgacg agtggggccc cgggttcgcc gcgatcaacc ggcccctgat cgacgggctc
     8161 gtggcgttgg ccgacgactg gggcccggac ctggtggtgt acgaccaggg gaccaccgcc
     8221 ggactgttcg cggcggcgcg cgccggggcg cccgccgtcc agcggaacgt gagcgcctgg
     8281 cgcacccggg gcatgcacga ggcggccgcg gcccacctgc ccgacgtctg cgagcggtac
     8341 ggcgtgtcca tctccaagcc ggccgtcacc atcgaggagt tcccgcccag catgctcgcg
     8401 ggcgagcagc cggagggctg gttcatgcgc tggctgccgc acagcggggg atcggtcatc
     8461 ggagaccggc tgccgcggcc ccccgagcgg ccgcgcatcg cggtgagcat gggcacggtc
     8521 gagctgcaga tgctgggcac cgggaccatg cgcacgatca tcgacgcggc cgccgacgtc
     8581 gacgccgagt tcgtgctggc gctcggcgga gtcgacatcg gctcgctcgg cccgctgccg
     8641 gacaacgtca gctccgtcgg ctggatcccg ctgcacttcc tgctgggcac gtgcaccgcc
     8701 atcgtccacc acggcggcgg gggaaccgcc ctgaccgcga tcgacgccgg cattccgcaa
     8761 ctgatcacac ccgaccccag ggacctgttc cagcacacga cgctggaggc ggtgcgcaag
     8821 cggggcatcg ggttcgtgag cgaacgcgag gacgtcgacg ccggactgct cacccggctg
     8881 atgaccgacg agggcgtacg cgccgccaca gcggaggtcc agcgggagat ggcgacgctg
     8941 cccacgcccg ccgccaccgt ccagcgcctc atcgagcacc tgttctgagg ccccggggcc
     9001 ctgcggggct accccctgcc cccgcgcccg gtcgcggggg cgggggcggg ggcaggggca
     9061 ggggcaggtc tgtcaggctt cggcggccgt gtccgcgggt accgtttccg gctccggccg
     9121 tggctcctcc cggcctacgg cttccaggtc cgcgcgcaga tcggacggca gcagcggctc
     9181 gtcgagaagc ctctggtacc gctcgaccag ggacgtccgg cccggaccgg cgttcagcca
     9241 cgcgcccacc agccgcgggc cttcgatgta ggtcaccgag taggcgcgcc agagcgggtc
     9301 ggtgaggaac ctcgtcatcc gccgggcatg gtcgggaggc accaggagcc agcgttccag
     9361 gtacccggtg acctggtcgg ggtcggcccc gcggtcgtgg agcatgatgg ccgcgtcctg
     9421 gcgcgcgggc atcagcagcc ggatcagccg caggacctcc tccaccagct cgccctcgac
     9481 ccgcactccc gcgtcggcca ggatgtcggc ggtccagcgg ccccagcccg gacccggcac
     9541 cgccgcgtcg gccatctcgg cggtgccctc ggccatgagg cactgcgggg tgttgaccag
     9601 cgagatcagg tgctcgccgt ggccggctcc gtcgacgagg ccggcctcct tgcggcagtg
     9661 ctcggtgtgg tgcccgggat aggactcatg gatcgccagc agcggcaggg cggcgatggt
     9721 gcggcccgcc tccgcgttga gctccaccct ggagcggaac ccgccgaggt agcggttgta
     9781 ggcgttccag ggcttgtcgc gcaccaccac gtactcgacg ctctcctgct ccggcaggtc
     9841 gaacaccgtg cgggtcatgg cccgcagttc gccggacacc gcctgcacgg cgcgcgccag
     9901 ccggtccggg gggacggcgt tgcgctcgta gaacgccgcg gtccgggcac gcaggtcccc
     9961 ggagcccggc aggagcgcgc cgatcgcgtc gtggatctcc gcgtagcggt cgggctcgcc
    10021 gagttcgatg tcgacctcga agtacgtccg gacctcgtcc ccgaacggga tctcctcccc
    10081 ggccatccgg cgggccgcgc agttcagcgc ggcgagctgc gcggacagga accggcgccg
    10141 cggctcggcc agcccgctgt cggggagcgc ggccagcagc cgggccgacc gggcggccag
    10201 cccggaggcg tcgggccgcg gttcggcctc cacccggcgg gccagctccg ggtcgccgta
    10261 ccaggagtcg acgaacccgt cggcgagccg gccgaaccgc agcccgaggc tgaggtactc
    10321 ggtcaccacc tcttcatgca tcagcgctcc ctggatcgcc acccggtggt ccgccgccgt
    10381 caccccgcag ggtcgtccgg cgggtcgagc cagacgccgg cgaggtcgta cgcatggccg
    10441 agcgcgggca tcgggatcgc gccccgcacc cgcgggccgc gcaggcgcgg gaccgccggc
    10501 cgctggaaca ggatcggcac gaccgcggcg tcctccagca ccgtccgctc ggccaggttc
    10561 cacgccgcgg tcgaccgcgc cggctcctcg atcgtggtga gcgcccgctc gatcaggcgg
    10621 tcgacctccg ggcgccggta gcggccgtgg ttcgcggagt tgcgggagtc gctcgactgg
    10681 aacatcggct gcaggaagac ccggccgttg ttcgggtgcc agtccggcga ccacgacgcg
    10741 gccgcgacgt cccacgctcc ctccgccgcg cgccccggat caccgaggag ggcgtcccgg
    10801 gcgtcgtggt cgagcgccac cagccggacg gtgacgcccg ccttctccag gtcggccgcg
    10861 tacgagcgcg cgaccgccgc gtccaggtcg gtgtcgagat ggaccgcggt gagcgccaga
    10921 ccgctcccgt ggcccgcctc ggcgagcagc gcccggcact tccgcgcgtc tccccggccc
    10981 cccggggtcg cgtagaggtc gagctcctgg tgcgcgtcgt tgcccggcgg cacgacggaa
    11041 ccggcgatcc gcaccagcgc accgccgccg gaccgccggt ggaggtcggc gatcgccgcc
    11101 ttgtcgatcg cgtacgacag cgcccggcgc accctggcat cggccagcgc gccgcccgcg
    11161 gtgggactct ggacgttgaa gacgaggtaa gggtcgaggg cgaggccgag gccgtcgccc
    11221 ggatcggccg gctcggcgtc gtgcggctcg gcgacccgca ccccccacgg caggtcggcc
    11281 gcgcccgacg cgacccgcgc ggcgacgcgt tcgggcgccg cgtcctcgac cgtgacctcg
    11341 acgccgtcga ggtaccggtg ccggagcgga tcggactcct gccgccaggc gggattgggt
    11401 tcgagccgca gctcgcggcc cggcacgaga tggacgggcc ggtacggccc gttgctccgg
    11461 aggttgcggt gcagttccgg gctgccgggc aggaacgcgt cgtactcgac cggggcgggc
    11521 gacgcgcacg gcagggccat gatggcggcg aagtcgatgg ccggccgcat gagctcgatg
    11581 accagcgact cgtcgtccag gacgaggacg ccggggatgt cgtgggagtt ctggaaggcg
    11641 gccagttcct cggcggccgg gtcgtcgcgg cggatcgccg cggcgtagtc ctcgcagtac
    11701 tgcgccatgc ccctgatcgt gctggtgaag tagggcaggg cggcgggcct cgtgagcggg
    11761 ttcgccagcc gcttcagccc gcgcacgacg tcgtgcgccg tgacctcccg cgcgggcgcg
    11821 gtgtcccaga agacgccgcg gcgcaggtgc accacgtagt tggtgtgccg cgcgcccatt
    11881 ccggtgttgt aggtggacgg gacgtcggtc gcgaggtcgg gcgccggggc gatggcccgc
    11941 cagtcgcgca ggtccggtgc gggggcgtag ccgaacagct gccgggcgaa cagcctgatg
    12001 agctggtcgg cgggcgcctg gtgggaggcc gacgggtcga ggcggtggac gggggccggg
    12061 ccgtggaggc ggagcgtccc gccgggccgc ggcaggtcct cgctccacgg ggcggcctgg
    12121 gggcggtcgg agacggtcat gacatctcct cgccgaggcg ggccatgatg ccgatcgccc
    12181 ggtcgatctc ctcgcgggtg ttgaacaggt gggtgcagac ccgcgccgcg tagtgctggt
    12241 gcggcgagcc cgggacgtcg aactcggtcc accggatcca gatgcggtgc tcccgctcca
    12301 ggcggtcggt gaacgcggtg aacttcttga tgttccaggc ggcctcgggg tcgcggaacg
    12361 ggttgaaggc gatgaggggg gacttcagca gcgggtcctc accgggcgag aagatcgact
    12421 ccttgccgaa ggcctccacg aggcgccgcc gggcgtggtc gccgagctcc atcgcccgcc
    12481 tctcgatgcg gtcccggccg atctcgtccc agatctcgca ggcccgcgcc agcgcggcgc
    12541 ccctggcgat gctcgcgctg ccggcgctct gcacgtacag ggcggtgtcg tcgctctcga
    12601 ccgacgtcct cgtccgcggc gggggactgc cgatcatcgg ataccaggtg gagatcacgg
    12661 gccagaacgt cggcagcggc agcgggttgt actcggggaa gaccttgttg cgcaggtaga
    12721 ggatgccggt tcccagcggc ccgcactgga acttcgaccc cgagcacgcg atgaagtcgg
    12781 cgcccagcgc ccgcatgtcc aggttcacga gtccgggcag cagcgcgccg tcgatcacgg
    12841 tggtcaggcc gtgccgctgc gccagctcgc acagcctgcg catcggcatc atcgtgcccg
    12901 tgaacagcgt gatcccggcg aacgcgagca ccttggtgcg gggggtgatg gccgcctcga
    12961 agaggtcgac gatctcgtcg gccgtgacgt cgtagccggt cggcatggtc agtgtcttga
    13021 tcgtcaggcc gtaccggttc cggacgaggt tgaagttgga gagcaccgag tagcactcgt
    13081 ggctcgtggt gaccacctcg tcgccctcgt gcaggtcgag cccctggatg atgcgggcga
    13141 cgccctcggt ggcgttgtgg cagatcacga tctcgtcctg gtcgacgccg aacgccctgc
    13201 cgatggcggc gcggtgctcg tagtagccgg acggcttgta gacgtcggcc agcccgccgg
    13261 tccactcgcg ggtcacccgg tcgatcgtgt cgagcacctc gtagggcatc gcgccgacgg
    13321 tgccggtgtt gaggtgggtc gtggtcggat ccagggcgaa cagttcgcgg atgctctccc
    13381 atggcgcgtc gcggagccgc cgcggtgatc cgccgttcgc cggcccggcc gggtccggga
    13441 cgctgcgctc gtcgggcttc acggactgtg tcacgagtga ccccctccac gtacggatga
    13501 ccagtctcct cacaatacaa tatgtttttg aagttacttg gccaatggac cccggatgag
    13561 ggcattccgc acgccgacgc cggtaccgtg cgccgcgccc cgctgtacgg gcgatgacct
    13621 tgatggatgc ggagtcgcgc gaggtcgagg cgggccgtgg agggagaccc ggcccgctgc
    13681 aggaggatcg cgagagactc cagtcaggtc tgatgcacct agggtgcttt aagaaacgat
    13741 ggtaatctcc ggcgtgggac gggcgggtcg ccgacggcgg ccgcggggcc cggcggcgtg
    13801 cagggaaggt gatcggtgtg gagcctcgtt acggtggaac actccgctac ttcggacctg
    13861 gcggaatgga ccacgtcgat cccgcgtgcg cctattacgc cttttcgcat cagatcatca
    13921 ggctgttcgc gcggcagttg ttcggctacc cgacggccgt ggacgagacc gccctgaccc
    13981 cggtccccga tgtcgccgcg gagtcgccga cgatcgccaa cggcgggatg agcccggacg
    14041 ggctcgtgta ccggatccga ctgcgcccgg gcgtcatgtg ggacaccgac ccgccgcgcg
    14101 aggtgacggc ggaggacttc gtgcgcggct tcaagcggat gtgcaacccg gtggccggcg
    14161 ccggggcgat cgcctactac acgagcacca tcaaggggat ggccgagttc gccgagggct
    14221 accggcggga gttcgccgga cgggccccgt cggccgccga cctggccggt taccagaacg
    14281 cgcacgagat ctccgggctg cgggccgacg gcgaccgcac cctggtcgtc gagctcgtgc
    14341 ggcccgccaa cgacctgctg aacctcctgt cgatgatgtt cgcgtccgcg gcgccgcgcg
    14401 agtacgacgc gttcgtcccg gacagtgccg agttcatcgc caatatccgt tccaacggcc
    14461 cgtaccgcct caccggctac gagaacggca gtcacctgac gatggagcgg aacccggtgt
    14521 ggcggcagga caccgatcct ctgcgccacc agtacgtcga cggcctggac gtgcggatgg
    14581 cgcgtgtcga cgacgaccgg gtgcgggagg cgatccggag cggggaggcc gatctctcct
    14641 ggggcgcgcc ggtcatcagc gaggaccgcc gtcccccgga cgcggaccgg catctcggct
    14701 acgcgatgaa cccctacctg gtgttcaacc tgaagacccc gaacgagggc ggggcgctgc
    14761 gcgacgtcag ggtgcgcaga gccgtcgcgt acgccgtcga caaggcctcc atggtcaggc
    14821 tgctcgacga catggacctg gggacggtga cccagaccgc gcacacggcg atccctccgg
    14881 gcaacttcgg gcaccgcgag tacgaccgct atccgacgcc gggggaccac ggcgatccgg
    14941 cgaaggcgcg ggcactgctc gccgaggccg ggtaccccga cgggctcacc ctcagggtcc
    15001 tgtaccgtgc cgacgcgccc cacgccgaca tcgcgcggta ctacgccgcc gacctggaga
    15061 aggccgggtt cacggtcgaa ctgcggctga tcagccagcc cgacgagtac taccggttcc
    15121 tgcagaaccc ggccatggcc gaggccggcg agtgggacat cacggcggcg gcgtggacgc
    15181 ccgactggtt cggcaacaac ggccgcgcct acgtccagcc gatgttccag tccaacttcg
    15241 ccgccggcac cagcaactac ggcgggtacc gcaacccgga ggtggaccgc ctcatcgagg
    15301 aggccctgtc cgaaccggat ccggcgcggg cggaggaact gtggcaccgg atcgaccggc
    15361 aggtcatcga ggacgtcgcg atcgtgcccg tcctggcctg cgagccgacc atcccccaca
    15421 tgaccagcgc ccgcgtgcgc aacggcctgc cgctgcccca ggtggaccgc tggctcgacg
    15481 cggcctgcat ctggctcgac ccgcccgact gacgccgcgg gcggcggtca gcgcggcacg
    15541 ccctcggcga tcgacatgac cgaggcggtg ggcaggacgc gcgcgagccg caggccggcg
    15601 gcctcgaaca gcgggtgcag ttccgcctcg gtgcgctcct gcccggtgcg cgccgcgagc
    15661 atcatgaagt ccatcggctt gctctggtgg gccgcgttgc cggccgggat gatcgcgtcg
    15721 acggcgagga cccgcccgtc cggcttcatc gcccgccggc agttgcgcag gatcgccacg
    15781 cacttctcgt cgtcccagtt gtgcaggatg cgcttgatca ggtacacgtc ccccgagggg
    15841 acggaggcga agaagtcccc gtcggtgatc tgccagcggc cggcgatgtc gtcgccgccc
    15901 agcaggtggt ggccgagcac gtgctcctcc tggtcgagga ggacgccgtg cagcccgggg
    15961 ttcctccgca gcacggcacg gaggaatccg cccttgcctc cgccgacgtc gacgaccgtg
    16021 ccggacgacg ggaacgcata gctcccggcg acgagggcgt tctcggcctc ggagaccgtg
    16081 gccatgccgt cgtagaagag cgcctcgatg tcggcgttct ccgcgaagta gccgccgatc
    16141 gtcgtgccga agagctgctc gaacgtcgtc gcctcgtccc gggcgacggt cgcggcctcg
    16201 tgggtgaccg tccagaacat ccggtcggtg aacatcagga tgcccgcgcg ggcggacatc
    16261 ggcgcgtcgg cgcgcagcgc gtcgcccctg gcggtcagcc ggaaccgtcc cggccggtcc
    16321 tcgtggacca cgccgcgtgc cgcgagcagc cgcaggatcc ggtacagcgc accctggccc
    16381 gtcccggtgg cggcggcgag ctcggccgtc gtgcgcgggc catcggccag gtggtcggcc
    16441 acgccgagtt cggccgccgc gcgcagcgcg gccgagtagg cgaaggccat cgcctcctcg
    16501 aagaggaaga gcgcggactg ctgcgcgtcc atgggcccct gctccctccc ggcggcagcc
    16561 cgccgtggtc cgacccagcc agagagttac tctatgaata taaagtatct ggggtcacaa
    16621 gcaacggtga gcggccctcg cctcgatcca tcgtggagga cgcccgatga gctacggagc
    16681 ggcacacgcc gaactctacg atcccgtgtt ccgcagccgc gggaaggatt tcgaggcgga
    16741 ggccgagggg ctgaaccgtc tggtccggtc cagatccccg aaagcgcgct ccctgctcga
    16801 cgtcgcgtgc ggcacgggcg cccacctgga gaacctcgcc aggtacttcg accacgtcga
    16861 agggatcgac cactcgcccg ccatgcggga cgtcgcacgc gggcgcctgc ccggcgtcgc
    16921 ggtgcactcc ggcgacatgc gggacttcga gctccaccgg accttcgacg tggtcatctg
    16981 catgggcagc gggctcgccg aggcggagtc gcccgagcag atggccgact cggtcgccag
    17041 gatgtcggcg cacgtcgctc cgggcggggt cctcatcgtc gaaccgtggt acttccccga
    17101 caacttcctc gacgggcatg ccgcggggca cctgttccgg gagaacggcc aggtgatctc
    17161 gcggatgacg cattcggcga ggcacgggga cacgagccgc gtggagatca ggttcgtgat
    17221 cgtggactcg tccgggttcc gggagttcac cgaggtgatc gtcaagtacc tgcttccccg
    17281 ggaagggtac gaggccgcct tcgagcgggc cggctgcacc gtcgagttcg tcccgggttt
    17341 ctcgctggcc gacggtcgcc cgaacagccc cgggctcctc gtcggcgtcc gcgccggcgg
    17401 caccgatcga accggatgaa gttgcttgac tttaatatag ttcgcgctcg atgctaacgc
    17461 catgcggagc gcagcggccc accgaatcgc ccttgtcaat gtcgccaacc acggcagcgt
    17521 gctccccacc cttccggtgg tgtcggagct ggtccggcgc gggcacgacg tcggttacgt
    17581 gacgtcgccg gagtacgccg gactggtcga gcggacgggc gcgaaggtgg tcccgtacgc
    17641 atcgggggcc gcgggtgcgg ccgaggcgtt cgcggacgac gacccggccc ggccgcacct
    17701 gctgtacctc gccgagaacg aggcgatcct gcgggcggcg catgcgcact acgccgagga
    17761 cgcgccggac ctggtgctgt acggagaagt gccgatcatc gccggccagg tgctggcggc
    17821 cgcctggaag cgccccgcgt gccggatcaa cccgggcttc gcctccaacc acgcgtactc
    17881 ctactcgcgg gagatgatcg aggagaccgg cggcgtcgac gagcgcacgc agggcgtcgt
    17941 caacgcgagg ctgggcgccc tgctcgccga gtacggcctg cgggaccggg ccggggagtt
    18001 cgccgaccgc gtcgaggacc tcaacctggt cttcgtcccc cgcgagttcc agatcgcggc
    18061 ggacaccttc gacgagcggt tcgcgttcgt cgggcgctcg gccgcgcatg aggagcggcc
    18121 tggcacgtgg cggcccccgg aagacggctc gccggtggtg ctgatctcgc tggggacgac
    18181 cttcaacgac catcccgact tctaccggca gtgcgcggag gcgttcgaga gcacgccctg
    18241 gcacgtggtg atggccctgg gggaccgggt cggagcgggc gatctcggcc ccctgcctcc
    18301 gaacgtcgag gcgcaccggt gggtctccct ccccgccgtg ctcgaacacg cgcgcctgct
    18361 cgtcacccac ggcggcatcg gtgccgtgat ggacgccctg atcgtgggcc ggcccatggt
    18421 cgtcgtgccg ttcacgttcg acgtcaagcc gatggcccgg cgggtgggcg agctcgggct
    18481 ggggacggtg atccccgcgg cggagttcac cggcgtgcgg ctgcgcgagg cggtggagga
    18541 actggcggat gaccgggcca cgctggaacg ggtgcgccgc atgcgcgagc acacggcccg
    18601 ggccggcggc gcggcccgcg ccgccgacgt gatcgagggc tatctcgcac ggagacgttg
    18661 accgggccga agaccgcgcc gtaactttaa aaaacgatac taaaacggtc gggcatcgtc
    18721 ccaacgagag ggagtccgcg atgattccgc tgttcaaggt cgcgatggcg ccggacgcgc
    18781 tcggccggat ctccgaggtg ctcgacagcg gccgcctgga gcacgggccc aagatggtcg
    18841 agttcgagga ggccctggcg ctgcgcctcg gcaacccgcg ggtcctcgcg gtcaactgcg
    18901 gcacctccgg tctccacctc gcgctcagca tggtggccga ccccgatcgc ttccccgcga
    18961 cggcccagcc ctccggtgac gccggcggtc cgggcgaggt gctgagcacg ccgctgacct
    19021 tcgaggccac gaactggccg atcctcgccc acgggctgcg cgtgcgctgg gtcgacgtcg
    19081 atccggccac gctgacgatc gacctcgacg acctcgccgc gaagatctcg ccggccaccc
    19141 gcgcgatcgt cgtcgtccac tggctgggct atccggtcga cctgaaccgg ctgcgcgaga
    19201 tcgtcgaccg ggccgaggag gcctacggat tccgtcccgt ggtgatcgag gactgcgcgc
    19261 aggcgtgggg cgcgacctac cggggggcgc cgctgggcaa ccacgggaac gtctgcgtgt
    19321 acagcttcgg cgccatcaag atcctcacct gcggaagcgg cgggctgatc gtgctccccg
    19381 acgaggacct gcaccggcgg gcccggctgc gccgctggct cggcatcgag cggcaggccg
    19441 accgggtgca cggcgactac gacgtcgccg agtggggcta ccgcttcccg atgaacgaca
    19501 tctccgcggc gataggactg tccaatctgg agatcgtcga cggcctgctc gcccggacgc
    19561 ggaagaacgc cgccttctac gacaaggagc tgtcggggat cgcgggcgtc gagcacaccg
    19621 agcgggcgga cgaccgggag ccctcgttct gggcgtaccc gctgaaggtg gcggaccgca
    19681 cgtccttcat gcggaagatg gccgacgccg ggatcatgac gagcatgatc tcccggcgca
    19741 acgacgccca cagctgcgtc gccgtcgcgc gggaagggct gccgggtctg gacggcgtgc
    19801 acgaccgcgt ggtctacgtg cccgtcggct ggtggctgtc cgaggaggag cgcggccaca
    19861 tcgcggacac catcaggtcg ggctggtgac cccgcggcgg ggggccgggc cgggcgggac
    19921 gcctagcctc ccgccagcgg cgggatgatc tcgacgcggc tgccgggcgc gagcgcgacg
    19981 tcgcccggcg gcgtcgcgcg gggcacctgc tcgccgtcca cgaggaacag gtggtagggc
    20041 agcaggtcgc cggccgggga gtagagccgg tagccggcct ccgggtgcga gctcacgaac
    20101 gtctccagga gctcgcgcag gttggccgcg ggcagctccg agcgcacctt gccggaggtc
    20161 acgttgtgcc agctgccggg gacgatgagg tggggcatgg ggcatcctca cgggtcgcgg
    20221 acgcatcgga aaccactggc gaagcaggcc cagccggtgg ggtcgccgtg caggcgctcg
    20281 ctggtccggg cctggaaacg caggttcatc caggagccgc cgcggatgac gcggaagcgg
    20341 tccatcacgg tcagcagcga ctcgtcgcag tcgggcgacg ggccgtagag gcggctcggc
    20401 gaggccgtcc actcgtagac gttgcccgcc atgtccgaca ccccgtacgg gctgtcgccg
    20461 tgcgggctga aactgccgac cggggtggtc agcgggatcg ggccctggtc gctctggagc
    20521 tccttccacc acgcgcgcca ctcggtggcg gtgcgggtgg cgtcgcccag ccgcagctcg
    20581 gtggtgttgg tcagctcgcg ggaccactcg tcgccccacg gccacagccg gtactcgggg
    20641 ccgcgcgcgg ccagctccca ctccgcctcc gtcggcagcc gcccgcccgc ccacgcggcg
    20701 aaggcctcgg cgtcctcgac cgcgatgtgg acggcgggat ggtcgtccgg cgggacgtag
    20761 ccggtgtcct gcccgcccgg acggcgccag gacgcgccgg gagtcccctg ccagtagtcg
    20821 gcgccgtaga ccaggctcca gccgcggcgt tcggcgaccg tccggtaccc ggtggcctcc
    20881 gcgaaggccg cgtaccggcc ggaggtgacc ggatagcggt cgatcacgaa cggcgcgacc
    20941 tccacgagcg tctgcggggt ctcgtcgcgg aaccagggcg tggggaaggg ctggtcctgt
    21001 tccgccagcc agtcgagcac ccactccggc gatccgagcc ggaacgccgc cccttcgatg
    21061 aggaccgagt cctcggcctc cacgccgccg cgcatcgccg tctcgtggtc tgccacagcg
    21121 ccatcctgta gatgatggtt ctcatcgaac agaaactata taaacatata gcattcaggt
    21181 gccgtccgcg ccacggctca ccgcccgatc ccgcggtagc cgaaaccgag gtcgcgcagc
    21241 cgccggatcg tctccgcccg gtagtgcatg cgcccgtcga agatcaggca cggcatcgcg
    21301 acctgccgcc gcagccgttc caggtcgatg tggcggaact gccggtgccc ggcgaggaag
    21361 gcgacggagt cggcgccccg caccgcctgt tcgaggtcgt cgacggggga gccgcccacc
    21421 tccgaccgga tccgctcctt gtcggcgagg ggatcgaaga cccggacctc cgcgcctgcc
    21481 gcctggaggg cctgcaccac gcccctgacg ggggtgttgc gcaggtcgcc ggtgtcgttc
    21541 ttgaaggcgg cgccgagaac ggcgatccgc gccgacgcca ggtccttgcc cagcttggcg
    21601 aggccgtccc tgatgacctc gtaggcgtac tcgggcatgg cgtcgttgac gtgccgcgcc
    21661 gtctccaccg tccgcagccg gacgccgcgg tcgcgggccg tgcgccaggt catccacggg
    21721 tccttggtca ggcacggccc gccgacgccc gcgccgggcc gcaggatgtt gacgcgcccg
    21781 tcccccttgg gcagcgagtt cgccgcggcg atgacctcca tcacgtcgac ctcgaacagc
    21841 gcgcagaacc gggccagttc gttggccatc gcgacgttcg cgtcgatcca ccagttgttg
    21901 gccagcttga cgatctcggc gatgtcggcc gtgggcacga tccggacggg cacgtccagc
    21961 gccgccttcc agaaccgagc cgccgccgcc gtgctgccgg ggccgcaccc gccgacgatg
    22021 accgtcagct cgcgcacctg ggccagcgcg tccccctcgg ccagccgttc cgggcagtag
    22081 gcgaggccga agtcccgccc ctcgaccagg ccgccgctct ccagcagcgg aacgaccagc
    22141 gtgcgcgtgg tccccggggc gacggtgctc ttcaggatga ccagctggcc ggcgcgcagc
    22201 cggggtgcga gctgccggca cacctcctcc agttgcgcgg tcagcagggc gccgttcccg
    22261 tcgacgggcg tgccgaccgt gatgagcacg acgtcggcct cacgcagggc gtcgtagtcg
    22321 gtggtgcacg ccagccgcgc gctcgcgacc agcggggcca gcgcctcggc caggccgggc
    22381 tcggggatcg cgcagcggcc cgcccgcagc ccggcgatca tcgatgcgtc gctgtcgatg
    22441 ccgatgacgc tcatgccgcg ctcggccagc gccaccccga tgcacgagcc gatgtagccg
    22501 aaccccagga tcgcgatccg cgggctggga gaatctgaca agaattccat ggtcgccttc
    22561 ctcgtcgttc tccgcgcctg cggcggtggc cgggtcgggc gtgcgcgcgg ccgccggacg
    22621 ccgccgatcg gctcggcgcc gccgggccta gttgcaatat attactgaag tgatgatggc
    22681 ctgggctggc ctgcgagtcc accggtccgc ggcgggccct gctgctcgtc ctcggggatc
    22741 ttccggacat ggtcattgga gtcgtccgat cacttgctat atgatagtta agtgagtgac
    22801 ctcgcgctcg tgacctccgg aacgggagat ggtgaccgag gaacgccctg ccggcgtcga
    22861 cctgtcctcg ctggcacagc gccatgtcga ccagtgggcc cccacgggcg ggcgcagccc
    22921 ctcgatcgcc cggctggccc gtaccgccgt ccggctggac gaggactact gccgggccgt
    22981 ggcggcgtac tacgaccgcg cgcccaggcg cggcggcgac gcggggctgc gccggcgcta
    23041 cgaccggttg aagcgccaga acctgcggca gttccggtcg atcgtcgagg ccggcatcga
    23101 gatcgccccg tggctcggag aggggcagcc gtacaaggga tcgcggcacc tgcgcgagag
    23161 cgtgcaccgg accggacggc tacacgtcta cctgaccagc tcgggccacg ggccctcgcc
    23221 ggccgccggg gaccatccgc tgtccgggcc gtcgggcgtc gtggtcgacg gcgtggagtt
    23281 ctgccacaac gacctgttcc gggccgtgca cgacatcttc gggcacgtga tgctcggcaa
    23341 cggcttcggc cccaaggggg agttcctcgc ggccttctgc cacatgcaca cgtactcgcg
    23401 ggacgtgcat ccgatcctgt tcaccgagca gatcggccag atctgctggt tcttctacgg
    23461 cccgcacctc ctggacggcg cgggcgggct gccggggccc ggggaccccg gctacctgcc
    23521 gccggcccgc cgtccgtacc cggagcagaa ggtcttcgcg ttcccggtgc gattcctcga
    23581 cgcgttcacg agcctgttcc agcccgagag gagtccggat gactgacgtg atgccgcaag
    23641 gagggggatc tccggtacgg ctcgcggacc aggcgttcct tcccagatcc atcagggacg
    23701 acttcccgat cctggcgacc gcgcaaggcg gcgagccgct cgtctacctc gacaacgccg
    23761 cgacggcgca gaagccgcag gcggtcctgg acgccctcgt cgactactac tccacggcga
    23821 acagcaacgt gggccgcggg tactaccggc tgagcatggc ctccaccgac cgctacgagg
    23881 aggcgcgcga gaccgtgcgg caggcgctcg gcgccgagca cgccgacgag atcgtgttca
    23941 cccggggcac cacggacgcg gtgaacctga tcgcggacgg cctgggcgcc cggctggtcg
    24001 gcgaagggga ccaggtcgtc gtcaccggca tggagcacaa ctccaacctg ctgccgtggc
    24061 ggcggctctg cgagcgggcg ggcgcggagc tggtggtcgc ccccgtcgac gagcggggcg
    24121 ccgtcgacgc cgcggccttc gccgccgtcc tcggcccccg cgtccggatc gccgccgtcg
    24181 cccacgtgtc caacgtgctg ggcaccgtca acccggtgcg cgagatgatc gccgaggcgc
    24241 accggcgcgg tgtcccggtc gtcgtggacg gcgcccaggc ggtgccgcac gcgccggtgg
    24301 acgtgcgcgg gctcgacgcc gacctctact gcttctcggg gcacaaggcc tacggcccga
    24361 tgggcaccgg ggtgctgtac ggcaagcggg acctgctcgc ggagctgccg ccctaccagg
    24421 tcggcggggg gacggtgaag ggggtgagcc acaccgagcc cgtccgctac gttcccgtac
    24481 ccgccaggtt cgaggcgggc accccgaacg tcgcgggggc cgtcggcctg gccgccgcgc
    24541 tgcggtacgt ccgcgatctc ggctgggacg ccgtgcggcg gcatgacgag gcgctggtgc
    24601 ggcacgcggt cgagtcgctg cggcagatcg acggcgtgcg ggtcgtcggc gaccccgccg
    24661 cagcgcccag cgggatcgtg tccttcgtcg tcgacggcat ccacccctac gacgtcggcg
    24721 ggcatctgga ccgccacggc gtggccgtgc gcagcggcgt gcactgcgcc agcaccttcc
    24781 tggacgagat gggcctgctc gggaccgtgc ggatgtcgtt cgccgtctac aacaccgccg
    24841 acgagatcga cgtcgtggcc gacgccctgc gctcggtgcg gccgggctcg tggaccaccg
    24901 accacccgac gacgcgtttc ctgtgacatg cgcttcgaca cgaggctggt ccacctcggc
    24961 caggaatccg acggcgtcac cggagacgtg gtgccgcccg tccatgtcgc ggcgacgttc
    25021 gagcggcggg tgcaggaccc gttgcgctac ttctactcgc gcggcgagaa cccgacgcgc
    25081 gaggccctcg aacgctgcct ggcggggctg gaggacgcgc gcttcgcgct cgccttcagc
    25141 tccgggcagg cggcggggac gacggcgctg tccctgctcc gcgccggccg caggctgatc
    25201 gcctcggacg acgtgtacgg cggcacccgg tcgctgttcg cgctcctcgg ccggtacggg
    25261 atcaccgtgg accacgtcga cctcaccgac gcgggcgcgc tcgacgccgc gctcggcgac
    25321 gacgtggaca tgatctgggt ggaggcgccg accaacccgc tgctgaaggt cgccgacctc
    25381 tcggtggtgt gcgagcgggc caggcgggcc ggcgcccgcg tcgtggtgga caacaccctc
    25441 gccggcccgg cgctgcagca gccgctgcgg ttcggcgccg acatcaccct gtacagcacc
    25501 accaagtcga tcgccggcca ctccgacgtc atcggcggcg ccctggtcta cgacgacgag
    25561 gacctgcacc gcgagctggc gtcccaccgc accaccacgg ggggcgtgcc cggcggcctc
    25621 gactgcttcc tggtgcatcg cgggctcaag acgctctcgt tgcgcgtggc gcggcaggtc
    25681 ggcaacgcgg aggcgatcgc cgccgcgctg cgcgggtgcg agcgggtggg cgccgtccac
    25741 tatccggggc tgcccgagca tccgcagcac gaggtggcgg cccggcagat gtcggcgccc
    25801 gggtcgatcc tgagcttcga gtacctcggc gatccggaga agctcctgga ccgggtgcgg
    25861 ctgtacgcgt gcgcggtcag cctcggcggc gtgcgctcgc tcatcgagtg ccccgccatg
    25921 atgacccacg cctccgtccc tcgcgaggtc cgggggcggc tgggcatctc ggacgacctc
    25981 attcgggtat cggcgggcat cgaggatccg gccgacctgg tgcgggacct gatggacgcg
    26041 ctctgaactg cggagggatg gacacatgaa cgacctatct gggggccgtc ggtccggagg
    26101 cgagggaccc ctgcggctgg acggcgggac cgcgaccgaa ctgcagcgcg ccggtatgag
    26161 cgtcgacggg ccgtggtgga ccaaccgggc catgaactcc gaggccgacc gcacgcggtt
    26221 gcgggggatc caccagggct acctgggcgc cggagcgcag gtgatcaccg ccaacacctt
    26281 ccggtgcaac ctgcgggcgc tcagccgtct cggcctcttc gacgccggcc tggcgtggat
    26341 ggtgcacgcc gccgtcggcg tggcccagtc ggcggtgcgc gccggcgagg aggggcgggc
    26401 ggacggacgg ggggaggcgg accgcacgct gatcgcgggc tcggtggggc ccgtcgagga
    26461 ctgctaccgg cccgacctgg ttccgcccga cgacgaactg cgggccgagc accgctggct
    26521 ggtgacggaa ctgatgcggg tgggcgtgga cctcgtcgtg atcgagacga tgaactccga
    26581 gcgcgaggcg cgcatcgcgc tggaagaggc gctgcgggcg ggcgcccgcg cctgggtcgg
    26641 cttcgtgtgc gacgccgacg cccggctgct gtcgggggag aagctgaccg aggcggccgg
    26701 cgccgtcgaa cgggagggcg ccgaggccgt gctcgtcaac tgcaccgctc ccgccgacag
    26761 cgagacggcg ctgcgggcgc tgcgggacgc ctgctcgggc cctatcggcg cctaccccaa
    26821 catcgaggac cgcaacggca tcccccgttc ggcgcacgtc gaccggcacg tccccgccgc
    26881 gctggggccc gacgagttcg ccgatctgat cgcccgctgg gacgcggagt tctccctcga
    26941 cgtggtcggc ggctgctgcg gcacgacacc ggaccatctg gccgccgccc acgagcggct
    27001 gctcgggagc gggcgatgag ggtccgcggc gtcccccgcc gagcgcggat cggctcatga
    27061 ggatcctcgt gaccggcggc gccggattcg tcgggtccca ctacgtgcgc cggctcctcg
    27121 acccggagcg ggcgggaggc ggcgcgcacc aggtcaccgt gctggacaag ctcacctacg
    27181 ccggcaacct ggccaatctc gacccggtgc gccgcgcgca cggcttcgcc ttcgtccacg
    27241 gggacgtcgc ggacgccgcg gtggtcgacg aactcgtcgc cggccacgac gcgatcgtcc
    27301 acttcgccgc ggaatcccac gtcgaccggt cgatccggtg cgcgcaggac ttcgtcgtca
    27361 ccaacgtcct cggcacgcag acgctgctgg aggcggcgcg ccgccacggc accgccccgt
    27421 tcgtgcacgt gtcgaccgac gaggtgtacg ggccgatcgg gacggggcgg tggagcgagc
    27481 gggacccgct ggcgcccagc aacccgtacg cggcgtccaa ggccgcggcc gacctcatcg
    27541 tgctcgcctg ccacaggacc ttcgggatgg acgtccggat cacccggggc tccaacacct
    27601 acggcccgta ccagttcccc gagaagatcg tcccgctgtt cgtcaccgag ctgctcgacg
    27661 gggggaaggt gccgctgtac ggcgacgggc tgcacgtccg cgagtggctc cacgtcgacg
    27721 accactgccg cgccgtgcac ctggcgctga ccaggggccg ggcgggcgag gtctacaaca
    27781 tcggcggcgt tccgctgacc aaccgcgagc tgaccggccg gctgctcgcc cagtgcggcg
    27841 cgggctggga cacggtgtcg tacgtggagg accgcaaggg gcatgaccgc cggtacgcga
    27901 tggactgcac gaagaccgcg acggagctcg ggttccggcc gcgccgggac ctcgtggccg
    27961 gcctcgcgga gaccgtcgcc tggtaccggg acaaccgcga gtggtgggag ccgctcacgt
    28021 tgcacgtgtc gcgggacgtg gaggtgaact cgtgacggct gcgaacatcg acccggccgc
    28081 cgtcaagcag gggcagcggg cctcctggga cgccctcagt tcgaactggg aggcggcgca
    28141 ggagaggttc gagctgggag cggccgcggt gacggagcgg ctgctcgacc tcggcggcgt
    28201 gcgggcgggc cacacggtcc tcgacgtcgg gaccggccac ggggagcccg ccctgacggc
    28261 ggcccggcgg gtggggccca ccgggcgggt gaccggcgtg gacatctccc cggcgatgct
    28321 cgacctggcc aggcgccggg ccgagggcac gcccaacgtc gagttcgccg aggcggacgt
    28381 ggagtccatc gacctgccga cggcctcgtt cgacgtcgtg ctcagccgct gggggctgat
    28441 gttcgcggtg gaccgggtcg cggccttccg cggactcgcc cggctcctgg tcccgggcgg
    28501 cgtgctcgcc gcggcggtct ggagcgaggc gcccagcgcg ccgacgatct cgctgggctt
    28561 ccgggtgctg agcgagcggc tcgaactgcc gcccccgccg ccgggcatgc cggggccgtt
    28621 cagcatggcc gacccggagc ggctcgccgc cgaggtggcc g
//
