LOCUS       NZ_BMRD01000021        27165 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence21, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000021
VERSION     NZ_BMRD01000021.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 172770)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 82476
            Orig. end                         :: 109641
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000021.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27165
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..27165
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27165
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:17165]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17165
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(253..1266)
                     /locus_tag="IEZ14_RS34715"
                     /old_locus_tag="GCM10010177_70070"
     CDS             complement(253..1266)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620614.1"
                     /locus_tag="IEZ14_RS34715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70070"
                     /product="GlxA family transcriptional regulator"
                     /protein_id="WP_179837770.1"
                     /transl_table=11
                     /translation="MGAGSVAVVVTEDIDVPSWDLYELSIPCTVFGKPQADLADPWYDL
                     RLCGTGTPDRDGAAAGAGLALRTRYGLDDLAGADTVIVPSVPDACVEDGAPLSPALVAA
                     LRRAYDAGARMVSLCTGAFALAEAGLLDGRRATAHWMHAAQLAERYPKVQVDASVLYVD
                     DGDVLTSAGLTAGLDLCLHLVRRDLGAQVANQLARRMVVAAHRAGGQAQFIPMSVAGTD
                     DEGVGPVLDWARARLDRPLTVQDLARRAALSPRTFYRRLQAATGTTPVQWLLNERLGQA
                     RHLLESTDLPVERIGELTGLGTANNLRHHFLKHVGIPPSEYRRAFPRTVPEPSARP"
     gene            1385..2272
                     /locus_tag="IEZ14_RS34720"
                     /old_locus_tag="GCM10010177_70080"
     CDS             1385..2272
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887675.1"
                     /locus_tag="IEZ14_RS34720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70080"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_179837771.1"
                     /transl_table=11
                     /translation="MDSEKQAVTVIGLGSMGSALAAALLDRGHPTTVWNRSPHKAAPLV
                     ERGALLAPTPGEAVAASPLVIACVLDYDALYGVLDQDASALAGKTLVNLTSGAPEQAHE
                     AVGWARERGADHLDGAIMTTPPGVGGAEVMFLYSGPQAVFQSHRPTLAALGDPLHLGEN
                     PGLASLYDVALLGLMWSTMTGWLHGTALVGSDGVAATDFTSIALRWLRTVSVFLTTYAP
                     QVDAGHYPGDDATVDVQIAAIGHLIHTAESRGVDNALPELTKTLMEKTKAAGHGLDSYA
                     SVIEVLKPREEEGE"
     gene            2269..2892
                     /locus_tag="IEZ14_RS34725"
                     /old_locus_tag="GCM10010177_70090"
     CDS             2269..2892
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892775.1"
                     /locus_tag="IEZ14_RS34725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70090"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_229810612.1"
                     /transl_table=11
                     /translation="MTTAPTAHSGPAPAPTTPWTGLLRATADECLDLLSGAAGSDWTRP
                     AHDLDWTCRETLDHLALGLIGYAGLLIARPSDRYIALFASLDAGAPIPACLEGIGIATS
                     LLASAVRETPADARAWHPWGHSDRTGFAAMGITELVCHTYDIAHALGVRWTPPDEASAA
                     VLDRLFPDAPTAHAPSDALLWCTGRVPLPERPRQANWQWNGTVR"
     gene            complement(3613..3909)
                     /locus_tag="IEZ14_RS34730"
                     /old_locus_tag="GCM10010177_70100"
     CDS             complement(3613..3909)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012855205.1"
                     /locus_tag="IEZ14_RS34730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70100"
                     /product="hypothetical protein"
                     /protein_id="WP_179837772.1"
                     /transl_table=11
                     /translation="MAMEASEVTEARRLRVWALAKALRSHGYAVEIAESLPLLAVPAAC
                     GPPVGVRCDLRAICGGELWFVFAGGGAIAPADDAHIPDAVVAVKGQLAAQADG"
     gene            4066..5301
                     /locus_tag="IEZ14_RS34735"
                     /old_locus_tag="GCM10010177_70110"
     CDS             4066..5301
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013151566.1"
                     /locus_tag="IEZ14_RS34735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70110"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_229810613.1"
                     /transl_table=11
                     /translation="MINEKRQRFGLYLAGLRRDARKSQRQLAESLCRISGTASVTRHEI
                     SRWERGERIPDVWISALSEALDVPLQTLERAAAHARGEDFSPEAPSPAEALSYFLPEDV
                     ELGPLANSTGRRVGTSTADALADRAHGLRLGDDVIASRDLLAPAFRELDGAVQLYRETT
                     HSEQTGRSLLGSIGEIAQITGWIASDAGQHDQAARAYRLGISAAREAGDLALVGHLAGS
                     LAYQLTNTGHEEDGLSLARAALEEAGPDAPPKARALYLDRVAWANTKAGNAQPAMRALA
                     QAHEAMDGEGSRDAPDWAYWVSPEELDVMDARVYTELHKPLRAVPLLQEVLSRYDSTRT
                     RELALYLSWLAVALVDANEPEEAASTARHMLDLSARFPSDRTAKRGRVVLTKLEPYRDV
                     PEVREVLDAYAA"
     misc_feature    4144..4146
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5324..5974)
                     /gene="msrA"
                     /locus_tag="IEZ14_RS34740"
                     /old_locus_tag="GCM10010177_70120"
     CDS             complement(5324..5974)
                     /EC_number="1.8.4.11"
                     /GO_function="GO:0008113 - peptide-methionine (S)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_function="GO:0033744 -
                     L-methionine:thioredoxin-disulfide S-oxidoreductase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654760.1"
                     /locus_tag="IEZ14_RS34740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70120"
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /protein_id="WP_179837773.1"
                     /transl_table=11
                     /translation="MFGFAKTQMVAPEKALPGRDEPIPVPPRHEVLDAPLAPPYPDGAE
                     IAEFALGCFWGAERKFWETPGVVSTSVGYEGGYTPNPTYEEVCSGLTGHTETVRVVHDP
                     AKVTYDDLLRVFWEAHDPTQGMRQGNDAGSQYRSAIFPRTDVQQKAAEASRDAYQQVLT
                     NAGYGPITTEITTAPDFYFAEDYHQQYLHKVPNGYCGTGGTGLSCPVGVAPAE"
     misc_feature    5968..5981
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.65"
                     /tool="antismash"
     misc_feature    complement(6029..6045)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.33"
                     /tool="antismash"
     gene            6048..6938
                     /gene="rarD"
                     /locus_tag="IEZ14_RS34745"
                     /old_locus_tag="GCM10010177_70130"
     CDS             6048..6938
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene="rarD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654759.1"
                     /locus_tag="IEZ14_RS34745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70130"
                     /product="EamA family transporter RarD"
                     /protein_id="WP_308427285.1"
                     /transl_table=11
                     /translation="MKRGMVCGVAAYVMWGLFPLYWPLLKPAGAGEILAHRIMWSLVAV
                     VAVLAVRRSRGWLRTLGWRRGALLALAALVISVNWGTYIYAVNSGHTIECALGYFINPL
                     ISVVFGVVIFQERLRRWQWAAVGMGAAAVVALTVDYGRPPWIALVLAFAFAVYGLLKKF
                     ADMPSAESLAVETTVTFLPALGFVLLLEGRGDAAFGHHGVGHAVLLAGAGIVTAVPLML
                     FNTAAIRLPLSVIGMLQYLAPVLQFAIGLFVQNEEMPPSRWAGFLLVWLALVTLTWDGL
                     TAGRREAMPETALRG"
     gene            6977..7336
                     /locus_tag="IEZ14_RS34750"
                     /old_locus_tag="GCM10010177_70140"
     CDS             6977..7336
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS34750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_70140"
                     /product="hypothetical protein"
                     /protein_id="WP_179837774.1"
                     /transl_table=11
                     /translation="MRLLSITVLGTALVAAGMLAPATGQATAGGDGPVSVEPRAVRPGE
                     RVRLSVPGCAGRVAAGSEAFAGRAVDGAAVVRRDAAPGAYPVAARCGSRKVIGEVQVAG
                     RVAWPELVPIDRAAK"
     misc_feature    7374..7387
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.46"
                     /tool="antismash"
     gene            7717..9087
                     /locus_tag="IEZ14_RS34755"
                     /old_locus_tag="GCM10010177_70150"
     CDS             7717..9087
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="IEZ14_RS34755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70150"
                     /product="cytochrome P450"
                     /protein_id="WP_179837775.1"
                     /sec_met_domain="p450 (E-value: 1.2e-70, bitscore: 231.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVDVGAVPVQKAKNFPLYRTVAGFVRDPLRQLERISTEGDGRLI
                     RLDLGASHPYLVTHPDHIQQVLRRESDIFQRDGVFWRPLRELMGDSILSEGAEWEHSKR
                     VLQPVFTTRNVNRLTGLMADAINDAVGKLEEPARAGRPIDVLPEMSRIVNETVIKVLFG
                     DKISPVEANKLIPTFDQIATSISVRFLLPFLPRVLPMPGDRAFKDAVQVMDEVLFELVA
                     RYRDDPGDGSDIFTALCQARAEDGAPPDDKWIRDNLLAMFATSTETTTLALTWLWPLLH
                     DHPDVLDRLVEEIEGVVGGEPVRPDHLSRLPYVSQVVQELLRLYPVGWMFPRMATAPTI
                     LGGVHIEPGDPVLISPFLTHRLGSVWERPLEFDPERFTPENSRERHRYAYFPFGGGPHQ
                     CIGRHVFDVEARMILTSLLSRFRPALSDAIPAMPRIGATLRPRESLEMTLTPVGRNA"
     gene            9084..10004
                     /locus_tag="IEZ14_RS34760"
                     /old_locus_tag="GCM10010177_70160"
     CDS             9084..10004
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889881.1"
                     /locus_tag="IEZ14_RS34760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70160"
                     /product="terpene synthase family protein"
                     /protein_id="WP_179837776.1"
                     /transl_table=11
                     /translation="MTGADTAPPHPGGAATPDALLDARHDGAVMAQAVKCARDLATCAE
                     TYPDLFDAKPIDETLFNAVACANAFGSPWLTASGIRMAARTSLWIFGLDWLVDHVATSR
                     DEVDDINRRCLAVAEGGAPAPGDGLTRFLADIRDEAAGSPAFAALRDDWLAQLRRLLEC
                     GARELAWKSGDRAAWPTFDEYLENADNYGSAWVNVSHWIVHADQSVLDHIGELQAASRD
                     VQQVLRLLNDLATYERDVTWGDLNAQMLGVERAQITTRIDEIVARCRDHLRPLRRDCPE
                     AAAYLERQIGFSTGFYELSDYWGSL"
     gene            10001..11755
                     /locus_tag="IEZ14_RS34765"
                     /old_locus_tag="GCM10010177_70170"
     CDS             10001..11755
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654755.1"
                     /locus_tag="IEZ14_RS34765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70170"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_229810614.1"
                     /sec_met_domain="T2TS (E-value: 1.4e-77, bitscore: 254.8,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVEEVGPEAAEAADPDPDDLRAAAGALVADLVNHPWGRSSPSVY
                     ETGRLVSLAPWLTGDSGRIRFLLDTQRPDGGWGPPDPGYALVPTLSATEALLSVLAPEG
                     RRWPAGLSVAEVVRGAGRALRALARRLGGATAADFPDMPAIEHITPALIEAINRHLDRL
                     RDDPVLTAWWTGGRLAPPAGMDGAFIAAARAHLENGGAVPLKVQHALEVAGASARRAGA
                     VRPVPLPAPTRPIRELSVANGPGRFATVGASTAATAAWLGGPDIDRGGDQAARRYLEAA
                     VEQHGGPVPVAVPVTNFERGWVLGWLARAGLAPAVPPELIAQMRASLGENGAPGGTGLP
                     PDADTSSGVLYALSLLGKPHPPDLLWKYETTTHFCSWPGENGRSVTTNAHVLEAFGHYL
                     ECGGAGPAGRYAASARKAASWLIGEQLDDGRWEDRWHASPLYATACAALALNEFGGPES
                     AGAVNRSVEWVLREQRSDGSWGRWCGTAEETAYAVHILTLARPSGDAAPDSAARKAVER
                     AVRRGDAHLRAALRSTPGALTGGPGDVDSGKPPLWHDKDLYRPTTIVWAAVLGALHLAR
                     RDTSVSAR"
     gene            11965..14400
                     /locus_tag="IEZ14_RS34770"
                     /old_locus_tag="GCM10010177_70180"
     CDS             11965..14400
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654754.1"
                     /locus_tag="IEZ14_RS34770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70180"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_179837777.1"
                     /transl_table=11
                     /translation="MRFRNSRLRTKIAALLVSLTALWAFAAWVTLREGVNLLFVSTLDS
                     VVAPSDPLLVELQQERRLTVTMLASGQRRPDVLAAQRARTDKERAIVVEKAGSGSVRRA
                     ADDEMDQRLDAMVRLLGRLDGDRRSIDAGAFDRRHIIDVYSDTIESIFHMYDGTTTLDD
                     RGFTSDLRAEIAVNRSWELLSQEDALVAGVLASGRITPVDQMDIAKAVGARRLNYERAL
                     VDLEGADRQAWNELNANKRLTTVSALEDVLLQRTKTHGPRMSAEQWRGATDPALAQMRK
                     TIQDAGDRLVERATPIATWVIIRLLLAGGLGLLAVIASIVVSITTARALVRQLERLRGA
                     AWELAEQRLPGVVERLGHGEKVDVEVEAPPLRFGNDEIGQVGRAFNAVQETAIRTAVEQ
                     AELRRGIRDVLLSLARRTQTLVHRQLTMLDTMERRRDIETKELEELFRLDHLATRMRRN
                     AENLIVLSGALPARGWRNSVPMVDVVRAAVGEVEDYTRVTVLPFGPVELAGRSVGDVTH
                     LLAELIENAVSFSPPDTIVQVGGHLVASGFAIDIEDRGLGMTDEKLAEINGRIADPPDF
                     NLQSSVQLGLFVVSKLAERYNLQVSLKRSAYGGTTAVVVIPRELIVEQGPAQVPAGTTT
                     TNGLEVRRPAAVGAASGAAIRSASPTVTLPPAGTGPQPVGPALVAVPPPAAEPLPVRPA
                     GGTAPETEPEAATPAGHGDPADGARPDPIEPEDLPPVPDISTTPSGLPVRVPQANLAEP
                     LRTDEPVAADEQDEQEDPGRSPEEIQRIMGSYQRGTQRGRVDAAEALGTNAAEGEAEQ"
     gene            14397..14822
                     /locus_tag="IEZ14_RS34775"
                     /old_locus_tag="GCM10010177_70190"
     CDS             14397..14822
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133477.1"
                     /locus_tag="IEZ14_RS34775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70190"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_179837778.1"
                     /transl_table=11
                     /translation="MTQKTGSSSDLGWLLDDLVHRLPHARSAVVLSADGLLMASSEGMT
                     QDDGEHLAAVAAGIQSLAKGAGTRFGGGPVRQTIVEMASAFLLVTVAGKGACLAVLASE
                     EVDVGLTAYEMAMLVTAMGHHLTSPSRSESAQEGRPA"
     gene            14819..15247
                     /locus_tag="IEZ14_RS34780"
                     /old_locus_tag="GCM10010177_70200"
     CDS             14819..15247
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654752.1"
                     /locus_tag="IEZ14_RS34780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70200"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_179837779.1"
                     /transl_table=11
                     /translation="MMPPEDPAQEPWADEAVTRPPLSDRFLDEHAGPMVRPYVMTSGRI
                     EPTRGKFDLITLVVAVGAEPEGAIALGPEHLSIIRLCQSVMSVAEITGHLDLPVATVRV
                     MLGDLLDKGFVSLQEPEPEADMHDIRLYKAVIDGLRAL"
     gene            15228..15842
                     /locus_tag="IEZ14_RS34785"
                     /old_locus_tag="GCM10010177_70210"
     CDS             15228..15842
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019632363.1"
                     /locus_tag="IEZ14_RS34785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70210"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_179837780.1"
                     /transl_table=11
                     /translation="MVSGPSRRDVRARRLPTAVKIVIAGGFGVGKTTMVGTVSETRPLR
                     TEELLTDESVGIDDISGVERKQTTTVAMDFGRITMRNEYVLYLFGTPGQERFWFMWDEV
                     SLGALGAVVLADTRRLSDCFPSVDYFERRGTPFIVAVNCFEGAQRYDLTEIQMALNLGP
                     KVPVMLCDARSLGSCKEVLIDLVLHAMKTRGLTEEPEPQKA"
     gene            complement(16164..17165)
                     /locus_tag="IEZ14_RS34790"
                     /old_locus_tag="GCM10010177_70220"
     CDS             complement(16164..17165)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PT_HPP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017593308.1"
                     /locus_tag="IEZ14_RS34790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70220"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_179839101.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 9.9e-59, bitscore:
                     192.1, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="PT_HPP (E-value: 1.2e-45, bitscore: 149.5,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQETGPFGLPVDAALASDAKERLAAVESLLLDCVRGEDPLLTEAS
                     QHLVEAGGKRFRPMLVLLASHFGDPAAPGVVPAAVVVELTHLGTLYHDDVMDEATVRRG
                     QQSANSRWTNTVAILTGDYLFARASDLLADLGPEAVRIQARAFARLVRGQIQETVGPGE
                     DADHLKHYLQVVADKTASLIAVSGQFGALLSGAPAHVVDTVTSACEKIGIAFQLSDDIL
                     DIDSETEESGKTPGTDLREGIRTLPMHHVLAGIGSGPDDARLRELLTQDLTDDALHAEA
                     LTLLRAHPAMDRARADLRRWAEDARTELLTLPEIPARDAFTNLCDYVVSRTG"
     gene            complement(17215..18801)
                     /gene="nuoN"
                     /locus_tag="IEZ14_RS34795"
                     /old_locus_tag="GCM10010177_70230"
     CDS             complement(17215..18801)
                     /EC_number="7.1.1.2"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /GO_process="GO:0042773 - ATP synthesis coupled electron
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654737.1"
                     /locus_tag="IEZ14_RS34795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70230"
                     /product="NADH-quinone oxidoreductase subunit NuoN"
                     /protein_id="WP_179837781.1"
                     /transl_table=11
                     /translation="MSTTSQVSAVLAQGGDIPAPHIEYGQIAPLLLVLGVAVVGVLVEA
                     FVGRSARYYVQVPLAFLGLAGAFGWTIALAWRDNPHHVAAEGALGVDGPTLFIQGTILV
                     LALVSLLLIAERGEGRAGGHFAAQASALPGSEAEQRTTEAGFTQTEVFPLMMFAVGGMV
                     MFPAANDLLTMFVALEVMSLPLYLLCGLARRRRLLSQEAAVKYFLLGAFSSAFFLYGAA
                     LLYGYAGSVRLSDISVQIGKDAGSETLLLAGVALLSVGLLFKLGGVPFHMWKPDVYQGA
                     PTPITALMASCTVVAAFGGILRVYYVAFETLKWDWRPLMWGVAILTMVAGSIIAITQTD
                     IKRMLAYSSIAHAGFLLMGVIASSADGLSSTMFYLVAYGFTSIGAFAVVTMVRDAGGEA
                     GHLSRWAGLGKRSPVVAGVFAFFLLGFAGIPLTSGFTGKFAVFKAAVESGATPLVIVAV
                     LSSAVAAFFYVRVIVVMFFSEPDAEGPVVVAGPATAVAVAVGVTATVVLGVIPQPVLDL
                     AGQATTHMFVR"
     gene            complement(18798..20414)
                     /locus_tag="IEZ14_RS34800"
                     /old_locus_tag="GCM10010177_70240"
     CDS             complement(18798..20414)
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /GO_process="GO:0042773 - ATP synthesis coupled electron
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019632350.1"
                     /locus_tag="IEZ14_RS34800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70240"
                     /product="NADH-quinone oxidoreductase subunit M"
                     /protein_id="WP_179837782.1"
                     /transl_table=11
                     /translation="MSDFPWLSVLIALPLAGAVLLTAIPREREALAKQFSLGVSLVVAV
                     LTGVMAAGFDAGGARFQFTEKYWWIKEFGVHWAVGVDGVALVLILLSVILVPLVMLASW
                     NEADRSGGVDAPARDEAGRGHGGGTQRSVKTYFALLLTMEAAMIGVFAATDVFLFYVFF
                     EAMLIPVYFIIGYYGGAQRSYAAVKFLLYSLFGGLLMLVAVIWLYPLSSRSVDEGGLGH
                     GTFMFDELSKMNIDPTTAKWLFLGFFVAFAIKAPMVPVHTWLPDAAQQSPAGALVLIVG
                     VLDKVGTYGMLRFCLELFPGAAKWATPVVLAFAVLSIIYGAVLAIGQVDMKRLIAYTSV
                     SHFGFIVLGIFAMTSQGQSGAALYMVNHGFSTGALFLVVGFMIVRRRSARISDFGGVQK
                     VAPVLAGMFLVAGLSALSLPGLSTFVSEFLVIVGTFSRYEWAGALAVSGVVLAAIYVLW
                     MYQRTMGGPKTPAVEGMKDLSAREKWALAPIIAIIVAMGLFPQPVLHVINPSVGHTLAR
                     VGEHDPAPDITGNVAENGARP"
     gene            complement(20411..22327)
                     /gene="nuoL"
                     /locus_tag="IEZ14_RS34805"
                     /old_locus_tag="GCM10010177_70250"
     CDS             complement(20411..22327)
                     /EC_number="7.1.1.2"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /GO_process="GO:0042773 - ATP synthesis coupled electron
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654735.1"
                     /locus_tag="IEZ14_RS34805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70250"
                     /product="NADH-quinone oxidoreductase subunit L"
                     /protein_id="WP_179837783.1"
                     /transl_table=11
                     /translation="MKAEGIQAASWLLVALPLAGAAILLLGGRRTDKWGHLLGAAMSVA
                     SFAVGAAMFAQMIGYDAETRRRTLHLWDFIDVGTFKVGMDLLVDPLSITFVLLITGVGS
                     LIHIYSIGYMAEDPDRRRFFAYLNLFLAAMLLLVLGGNFLILFLGWEGVGLASYLLIGF
                     WQHKPTAATAAKKAFVVNRVGDMGLIIAIALIFASFGTIDFGSVLGTGAEHVGLASKLG
                     TGTATAIGLLLLVGACGKSAQLPLQSWLLDAMEGPTPVSALIHAATMVTAGVYLIVRSG
                     PIFEMSETAQLVVTIVGAATLLAGAIIGCGKDDIKKALAGSTMSQIGYMVLAAGLGPAG
                     YVFAIAHLVAHGFFKAGLFLGAGSVMHGMKDDVNMRHYGALRTVMMITYVTFGLGYLAI
                     IGFPGLSGWFTKDGIIEAAYDKGGTSGLILGSCALIGAGITAYYMSRVMFMTFFGEKRW
                     EDDVHPHESPAVMTWPLMLLAVGSVFAGGFLILGSFPEFLEPVVGAPEHAHEFKWLTAP
                     GAATFVLMIVGAGIAWMQYGARKVPREAPKGSFVTVAARKDLYGDALNESLLMRPGQWL
                     TRLAVWFDGRGVDGAVNGTAAGVGGSSGRLRRVQTGFARSYALSMLGGAALVVAALLVV
                     NVS"
     gene            complement(22338..22637)
                     /gene="nuoK"
                     /locus_tag="IEZ14_RS34810"
                     /old_locus_tag="GCM10010177_70260"
     CDS             complement(22338..22637)
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /GO_process="GO:0042773 - ATP synthesis coupled electron
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019814967.1"
                     /locus_tag="IEZ14_RS34810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70260"
                     /product="NADH-quinone oxidoreductase subunit NuoK"
                     /protein_id="WP_021593191.1"
                     /transl_table=11
                     /translation="MSPGHYLALSAILFTIGALGVLVRRNAIVVFMCVELMLNATNLAF
                     VSFSRMHGNLDGQIIAFFVMVVAAAEVVVGLAIIMTIFRTRRSSSVDDANLLKY"
     gene            complement(22634..23554)
                     /locus_tag="IEZ14_RS34815"
                     /old_locus_tag="GCM10010177_70270"
     CDS             complement(22634..23554)
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017593303.1"
                     /locus_tag="IEZ14_RS34815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70270"
                     /product="NADH-quinone oxidoreductase subunit J"
                     /protein_id="WP_179837784.1"
                     /transl_table=11
                     /translation="MTGSVASAHVLAAEVADKQSGEPFFFWLLAIVSVLAALGMIFMRK
                     AVHSALLLATVMLCLAALYAIQNAPFLAFVQVIVYTGAVLMLFLFVLMLVGVSSTDSLV
                     ETIRGQRFWAVLAAIGFLVLLSVGVGNAALGGSAGLTQANSEGNIVGLARLLFSKYVFA
                     FEATSALLITAALGAMVLAHRERTEPKPTQKDLSRQRFLSGSHPGPLPGPGTYARHNAV
                     DMPALLPDGTPSELSVNPVIAARTDTAERHADLYGGSEEEALERDVAAVKAVTEDVRDT
                     DAEARSVKSGTPAAGGGASEGEAGE"
     gene            complement(23551..24201)
                     /gene="nuoI"
                     /locus_tag="IEZ14_RS34820"
                     /old_locus_tag="GCM10010177_70280"
     CDS             complement(23551..24201)
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017593302.1"
                     /locus_tag="IEZ14_RS34820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70280"
                     /product="NADH-quinone oxidoreductase subunit NuoI"
                     /protein_id="WP_179837785.1"
                     /transl_table=11
                     /translation="MGLTDFLNPVKGFGVSFHQMFMKSETVQYPEVKKPTAPRFHGRHQ
                     LNRWPDGLEKCIGCELCAWACPADAIFVEGADNTAEERYSPGERYGRTYQINYLRCILC
                     GLCIEACPTRALTMTNEYELADDSRESLIYTKEMLLAPLREGMETPPHEMRLGDTEEDY
                     YRLGLQESEQSPSSGTPSAPKVPAEGGGRAGADQAAEREKARREKARKGGEGK"
     gene            complement(24188..25528)
                     /gene="nuoH"
                     /locus_tag="IEZ14_RS34825"
                     /old_locus_tag="GCM10010177_70290"
     CDS             complement(24188..25528)
                     /EC_number="1.6.5.9"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654731.1"
                     /locus_tag="IEZ14_RS34825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_70290"
                     /product="NADH-quinone oxidoreductase subunit NuoH"
                     /protein_id="WP_179837786.1"
                     /transl_table=11
                     /translation="MSSLAAAPAPDPRLQDFGSDPWWLIGGKVLAIFVFLVVTVLMTMW
                     IERRVIGRMQLRVGPNRAGPFGLLQGLADGVKLALKEDIVPRQVDKIVFVLAPVMAAVP
                     AFISFIIIPFGPTVSIFGHQTALQGTDLPVAVLLVLAMSSMAIYGIVLAGWSSMSPYSL
                     LGGLRSSAQMISYEIAMGLSFVAVFMFAGSMSTSEIVAAQHDKWFVVLLAPSFVVYVIT
                     MMGESNRIPFDLPEGEGELVGGFHTEYSSLKFAMFFLAEYINLATLSALATTLFLGGWR
                     APAPISTVWAGANSGWWPVLWFLIKIFLFIFFFIWLRGTLPRVRYDQLMKLGWKVLMPF
                     SLGWILLVATIRALRNDGYEMRQLFIAAAVVAAIVLVATVIWEMARGREDDKEIVPGAT
                     PGPRTDPSAGGFPVPPMDAPHYHGRAREPDRPVTIETPSEEVTSGTH"
     misc_feature    27139..27150
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
ORIGIN
        1 accttttccc attccggggg cgccgccgcg gcggtggacg gcatgagcag caggccggag
       61 agggcggcgg tccaggcggc gacgcgaagg actcgatgta cggccatgaa tactcccggg
      121 gcggttaggc ggcacccttg tgacgatctt gccgccattt actggcaaac tatcgggatc
      181 tacctatccc aaggtcgctc cgctcaaaca gacgaaaccg ttcacatgag ctaccgtgca
      241 ggccaacgag tgtcagggac gggcggacgg ctcgggcacc gtgcggggga aggcccggcg
      301 gtactcgctg ggcgggatcc cgacatgctt gaggaagtgg tggcggaggt tgttcgccgt
      361 gcccaggccg gtcagctcgc cgatccgctc gaccgggagg tccgtcgatt ccagcaagtg
      421 ccgggcctgt cccaggcgct cgttgagcag ccactggacc ggggtcgtcc cggtggcggc
      481 ctggagccga cggtagaagg tccgcgggct caacgcggcg cgccgcgcca ggtcctggac
      541 cgtcaacgga cggtccaggc gggcccgggc ccagtcgagg acgggaccga ccccctcgtc
      601 atcggtgccg gccacggaca tggggatgaa ctgcgcctgg ccgccggcgc ggtgggcggc
      661 tacgaccatc cggcgggcga gctggttggc gacctgggcg ccgaggtcgc ggcggaccag
      721 gtgcaggcac aggtcgagac cggcggtcag ccccgcgctg gtcagcacgt caccatcatc
      781 cacgtacagc accgaggcgt cgacctggac cttcgggtag cgctccgcca attgggcggc
      841 gtgcatccag tgggccgtgg cgcgacggcc gtcgagcagc cctgcctcgg cgagtgcgaa
      901 cgcgccggtg cacagggaga ccatgcgagc ccccgcgtcg tacgcgcggc gcagcgccgc
      961 gaccagcgcc ggactgagcg gcgcgccgtc ctcgacgcag gcgtcgggca ccgaggggac
     1021 gatgaccgtg tcggcgccgg cgagatcgtc cagcccgtaa cgggtccgca gcgcgagccc
     1081 ggcgccggcc gccgcgccgt cccggtccgg cgttccggtc ccgcacagcc gcaggtcgta
     1141 ccagggatcg gccaggtcgg cctggggctt gccgaagacg gtgcacggga tgctcagctc
     1201 gtagaggtcc caggagggga cgtcgatgtc ctcggtcacg accacagcga cagaaccggc
     1261 acccatgccc cgaatgctat ggcaggaatt tggtgacgcc cgtcattact gtcactggtc
     1321 cggtaccagg ctccctgcga acgtgatccg cacatgttct tccaggacac tccaggggcg
     1381 tgagatggat tctgaaaagc aggccgtgac cgtcatcggg ctggggtcga tgggctcggc
     1441 gctcgccgcc gcgctgctgg accgcggtca cccgaccaca gtgtggaacc gttcgccgca
     1501 caaggccgct cccttggtgg agcgcggcgc gctccttgcc ccgacgcccg gggaggcggt
     1561 cgcggcgagc ccgctcgtca tcgcctgcgt actcgactac gacgcgctgt acggcgtcct
     1621 cgaccaggac gcgagcgcgc tggcgggcaa gacgctggtc aatctcacct ccggcgcgcc
     1681 ggagcaggcg cacgaagcgg tcggctgggc ccgggagcgc ggcgccgacc acctcgacgg
     1741 cgccatcatg accacgccgc ccggcgtcgg cggtgccgag gtgatgttcc tgtacagcgg
     1801 tccccaggcc gtcttccagt cgcaccgtcc gacgctggcg gccctcggcg accccctcca
     1861 cctcggggag aacccggggc tggcctctct ctacgacgtc gccctgctcg gcctgatgtg
     1921 gtccacgatg accggctggc tgcacggcac cgcgctggtc ggctcggacg gcgtcgcggc
     1981 caccgacttc acctccatcg cattgcgctg gctgaggacc gtgtcggtgt tcctgaccac
     2041 gtacgcgccg caggtggacg ccggccacta tccgggcgac gacgccaccg tcgacgtgca
     2101 gatcgcggcc atcggccatc tcattcacac cgccgagtcc cgaggcgtcg acaacgccct
     2161 gcccgagctg acgaagaccc tcatggagaa gaccaaggcg gccggccacg gcctcgacag
     2221 ctatgccagc gtgatcgagg tcctgaagcc gcgagaagag gagggcgagt gaccacggca
     2281 ccgaccgcgc acagcggtcc ggccccggca cccacgacgc cctggacggg cctgttgcgg
     2341 gcaaccgccg acgagtgcct ggacctcctg tccggcgctg ccggctcgga ctggacacgc
     2401 ccggcccacg acctggactg gacatgccgc gaaacgctcg atcacctcgc cctagggctg
     2461 atcggctacg ccggcctgct catcgcccgg cccagcgacc gctacatcgc cctcttcgcc
     2521 tcactcgacg ccggcgcccc cattcccgcc tgcctggaag ggatcggtat cgccacctcc
     2581 ctcctcgcct ccgccgtccg ggagacgccc gccgatgcgc gcgcctggca tccctggggc
     2641 cattccgacc gcaccgggtt cgccgccatg gggatcacgg agctggtctg ccacacctac
     2701 gacatcgccc acgccctcgg cgtacggtgg acaccgcccg acgaggccag cgccgccgtc
     2761 ctcgaccggc tcttccccga cgcgccaacg gcgcacgctc cctccgacgc cctgctgtgg
     2821 tgcacgggcc gcgttccgct gccggagcgg ccccggcagg cgaactggca gtggaacggc
     2881 accgtgcgct gaccagctgg cggcgccgcg ctcaccgagg acacgagtct tcgcggggcg
     2941 cggtgctccc gcgacaggcc cccgtgctgt ggaacgccca cgcccccgag ctgtggcgac
     3001 gcctcaccgc cccaccgtgg acggcccgcc catcccacac cgcccaagct gaggaaggcg
     3061 ccgcgcgagg gcccgccgca tgaagtgccg ggcagcggct tccaggccgg gcgacgcttg
     3121 agacggaatt gccgacacgg cgccggctga ccccctcccg gtcgcccctc cggggtggcc
     3181 tccgaccatc gaccggcccc gaccctgtca gcgcgaaagg gaagccgcgg ccctcaactc
     3241 gtcgcaacag atcaagagaa ggccccgcct ctctgccatg ggggcaaagc agagaagcgg
     3301 ggcggcggac gacaacaacg gtcatgctcc ccggctcaag accgcgcgtc accgccatga
     3361 atgagggacg actcctgagc ccgccccata gagtcgtccc tcttgtggcc tcccgggggc
     3421 gcttgattgg cgctgatatg cgggaacgaa cttgtgggca ggccacggcc aggccgccgg
     3481 attccgcagc gcttcccgca attcgtcacg ggtggccgct ccagcagccg tgccccgtcc
     3541 ggcgtgggga ccagcgccca ccacgctccg gtagcccgtc cgtaccagat gaccgcaccg
     3601 gacgacgagt gcctacccat cggcttgcgc ggcgagctgg cccttcactg ccaccaccgc
     3661 gtcaggaatg tgcgcgtcat cagccggagc gatcgcacca ccgccagcga agacgaacca
     3721 caactcaccc ccacagatcg cccgcagatc acaacgcacc cccaccggcg gcccacacgc
     3781 agccggaacc gccagcagcg gaagtgactc agcgatctcc accgcgtatc cgtgcgacct
     3841 gagcgccttc gccagcgccc agacccgcaa ccgccgcgcc tccgtcacct ccgaagcttc
     3901 cattgccatg ggagctatcc cttcatcgag gcgcaggacg ggggttgacc gttggtacct
     3961 gccgcctctt ccatgcctag agcctgtctt ttcgggctgt ctcctcagag gcgcctacca
     4021 gggggccggg gaggggccag actgaggagt gagggagggg ccagcgtgat caacgaaaag
     4081 cggcaacggt tcggtcttta tctcgcgggg ttgcggcgag acgcacgcaa gagccaacga
     4141 cagttagcgg aatcgttgtg ccgcatctca ggaacggcgt ccgtgacacg ccacgagatc
     4201 agccggtggg aacgaggcga gcgaatcccc gatgtctgga tttctgccct ctccgaggcc
     4261 ctagacgttc cccttcagac gcttgaacgg gcagccgccc atgcgcgcgg cgaggacttc
     4321 tcgcccgaag cgcccagccc agcggaagca ctctcctatt tcctgcccga agacgtcgaa
     4381 ctcggaccac tggcgaacag cacaggccgt cgagtcggga cgtccacggc ggacgcgctt
     4441 gccgaccggg cgcacggcct gcggctcggg gacgacgtca tcgccagccg cgatctactc
     4501 gcgccggcct tcagagagct ggacggcgca gtccagctct atcgggagac gacgcattcc
     4561 gagcagaccg gccgctcact cctcggcagc atcggcgaga tagctcagat caccgggtgg
     4621 atcgccagcg acgcgggcca gcatgaccag gcggcacgcg cataccggct cggaatctca
     4681 gcggccaggg aggccggaga cctcgcactc gtcggtcacc tcgccgggag tctggcctat
     4741 caactcacca acaccggcca cgaagaggac gggctgagtc tggcccgcgc cgcgttggaa
     4801 gaggcaggac cagacgcacc gcccaaggcc cgcgcgctct acctcgaccg agtcgcatgg
     4861 gcgaacacca aggcaggcaa cgcgcaacca gccatgcgcg cacttgccca agcccacgaa
     4921 gccatggacg gggagggctc gcgggacgca ccggattggg cctactgggt ctcgcccgag
     4981 gaactcgacg tgatggacgc ccgcgtctac accgagctgc acaaacccct acgggccgtc
     5041 ccactcctgc aagaagtgct cagccggtac gactcgacac gcacgcgcga actcgccctc
     5101 tatctctcat ggctcgcggt cgccctggtg gacgccaacg agcccgagga ggcagccagc
     5161 accgcgcggc acatgctcga cctctcggcc cgcttcccca gcgaccggac tgcgaagcgc
     5221 ggacgagtcg tcctcaccaa actggagccg taccgggacg ttcccgaagt gcgcgaggta
     5281 ctcgacgcct acgccgcttg accgctgcgc agcaggtcag acgctactcg gcgggggcta
     5341 cgcctacggg gcaggagagg cctgtgccgc ctgtgccgca gtagccgttg gggaccttgt
     5401 ggaggtactg ctggtggtag tcctcggcga agtagaagtc gggggcggtg gtgatttcgg
     5461 tggtgatggg gccgtagccg gcgttggtga ggacctgctg gtaggcgtct cgggaggctt
     5521 cggcggcctt ctgctggacg tcggtgcggg ggaagatcgc tgagcggtac tggctgccgg
     5581 cgtcgttgcc ctggcgcatg ccctgggtgg ggtcgtgggc ctcccagaag acgcggagca
     5641 ggtcgtcgta ggtgaccttg gcggggtcgt ggacgacgcg gacggtctcg gtgtggccgg
     5701 tcaggccgct gcagacctct tcgtaggtgg ggttcggggt gtagccgccc tcgtagccga
     5761 ccgaggtgga gacgacgccg ggggtctccc agaacttgcg ttcagcgccc cagaagcagc
     5821 cgagggcgaa ctcggcgatc tcggcgccgt cggggtaggg cggcgcgagg ggggcgtcga
     5881 ggacctcgtg gcgcggcggc accgggatgg gctcgtccct gccggggagt gccttttccg
     5941 gagcgaccat ctgggtcttc gcaaagccga acatgcgtcc aggctactcg gccgcctgtc
     6001 agcaccgttg ttccctttgg ttgattacct gttgatatgt tgccattgtg aagcggggca
     6061 tggtgtgcgg ggtcgcggcg tacgtgatgt gggggctgtt cccgctctac tggccgctgc
     6121 tgaagccggc gggggccggc gagatcctcg cgcaccggat catgtggtcg ctggtcgcgg
     6181 tggtcgcggt gctggccgtg cggcggagcc gggggtggct gcggacgctg ggatggcggc
     6241 ggggcgcgct gctggcgctg gcggcgctgg tgatcagcgt caactggggg acgtacatct
     6301 acgccgtcaa cagcgggcac acgatcgagt gcgcgctggg gtacttcatc aacccgctga
     6361 tcagcgtggt gttcggtgtg gtgatcttcc aggagcggct gcggcggtgg cagtgggcgg
     6421 cggtcgggat gggggcggcc gcggtggtcg cgctgacggt cgactacggg cggcctccct
     6481 ggatcgcgct ggtactggcg ttcgcgttcg cggtgtacgg cctgctgaag aagttcgccg
     6541 acatgccttc ggccgagagc ctggcggtcg agacgaccgt gacgttcctg ccggcgctgg
     6601 ggttcgtgct gctgctggag ggacggggcg acgcggcctt cgggcatcac ggcgtggggc
     6661 acgcggtgct gctggccggg gccgggatcg tgacggccgt gccgttgatg ctgttcaaca
     6721 ctgcggcgat caggctgccg ctgagcgtca tcggcatgtt gcagtacctg gcgccagtgc
     6781 tgcagttcgc catcgggctg ttcgtgcaga acgaggagat gccgccgagc cggtgggcgg
     6841 ggttcctgct ggtctggctg gccttggtga cgctcacgtg ggacgggttg accgccggac
     6901 gccgggaagc gatgcccgaa acagccctta ggggctaaag tgccggacgt cacacccccg
     6961 agtgagggag tcgtcgttgc gtctgctcag catcaccgtg ttgggaacag cgctcgttgc
     7021 ggcgggcatg ctggctccgg cgacggggca ggcgacggcg ggcggggacg gtccggtctc
     7081 ggtggagccc cgcgcggtgc gtcccggtga gcgggtccgg ctctcggtgc cgggatgcgc
     7141 gggcagggtg gccgcgggtt ccgaggcgtt cgccggacgg gccgtggacg gcgcggccgt
     7201 cgtgaggcgg gacgcggcgc ccggcgccta tccggtcgcg gcacgctgcg gatcacggaa
     7261 agtgatcgga gaggtccagg tggcgggtcg ggtcgcgtgg cccgaactgg tcccgatcga
     7321 ccgcgcggca aagtaattcg gtataaaccg gaagagggct ccatttatcg gatgtcactc
     7381 tccgtgttct cccacgcctt gtaaatgccc ttatcgcggg ctcctcgggc atgcctgtaa
     7441 ggccgacccg gacaatgaga caacacaacc ggcaagtgat aagggtcacg tcggaacggt
     7501 tgagatttct accggccgaa gccttgccga tgttaattga tcatgtgata ctcccacaga
     7561 aagctacata acaccgcaac cttcccacaa agcccgaatc actcattcac gtcgtcccgc
     7621 cgcgagggac gtcgtgcgtc ccaggcggcc gcgaaccccg ggacggccat ccgcgagcac
     7681 tggtactcca actcaacatc gaggggcagt cggtaaatgt ccgttgacgt cggcgccgtc
     7741 ccagtccaga aggcgaagaa cttccccctc taccgcacgg tcgccggctt cgtccgcgac
     7801 ccgcttcgcc agctggaacg gatcagcacg gagggggacg gccggctcat ccggctcgac
     7861 ctcggtgctt cccaccccta cctggtcacc catcccgacc acatccagca ggtcctgcgg
     7921 cgcgagtcgg acatcttcca gcgggacggg gtgttctggc ggccgctgcg cgagctgatg
     7981 ggcgacagca tcctctccga gggcgccgag tgggagcaca gcaagcgggt gctgcagccg
     8041 gtcttcacca cccgcaacgt caaccggctc accgggctga tggcggatgc gatcaacgac
     8101 gccgtcggga agctggagga gcccgcccgc gcgggacggc cgatcgacgt gctgccggag
     8161 atgagccgga tcgtcaacga gaccgtgatc aaggtcctgt tcggcgacaa gatctccccg
     8221 gtcgaggcca acaagctgat cccgacgttc gaccagatcg cgacctcgat ctcggtccgg
     8281 ttcctgctgc cgttcctgcc gcgcgtgctc ccgatgccgg gcgaccgggc gttcaaggac
     8341 gccgtgcagg tgatggacga ggtcctgttc gagctggtgg cgcgctaccg ggacgatccg
     8401 ggcgacggca gcgacatctt caccgcgctc tgccaggcgc gggccgagga cggcgcgccg
     8461 ccggacgaca agtggatccg cgacaacctg ctcgcgatgt tcgcgaccag caccgagacc
     8521 acgacgctgg cgctgacctg gctgtggccg ctgctgcacg accacccgga cgtcctggac
     8581 aggctggtcg aggagatcga gggcgtggtg ggcggcgaac cggtccggcc cgaccatctt
     8641 tcgaggctgc cgtacgtgtc gcaggtcgtc caggagctgc tgcgcctgta cccggtcggc
     8701 tggatgttcc cgcgcatggc gaccgccccg acgatcctcg gcggcgtgca catcgagccg
     8761 ggcgacccgg tgctcatcag cccgttcctc acgcaccggc tggggtcggt gtgggagcgt
     8821 ccgctggagt tcgacccgga gcggttcacg ccggagaact cccgcgagcg gcaccgctac
     8881 gcctacttcc cgttcggcgg cggaccgcac cagtgcatcg gccgccacgt gttcgacgtc
     8941 gaggcgcgga tgatcctgac gagcctgctg agccggttcc gcccggcgct ttccgacgcg
     9001 atccccgcca tgccgcgcat cggcgcgaca ctgcggccgc gggagtcgct ggagatgacg
     9061 ctgaccccgg tcgggcggaa cgcgtgaccg gggcggacac ggcgcctccg catcccggag
     9121 gcgccgcgac gcccgacgcc ctcctggacg cgcggcacga cggagccgtc atggcgcagg
     9181 ccgtgaagtg cgcccgcgac ctggccacgt gcgccgagac ctatcccgac ctgttcgacg
     9241 ccaagccgat cgacgagacc ctgttcaacg ccgtggcctg cgcgaacgcg ttcgggtcgc
     9301 cgtggctcac cgcgtccggg atccggatgg cggcacgcac ctcgctgtgg atcttcggcc
     9361 tggactggct ggtggaccac gtcgcgacgt cccgggacga ggtggacgac atcaaccggc
     9421 gctgcctcgc cgtcgcggag gggggcgcgc cggcgccggg ggacgggctc acccggttcc
     9481 tcgccgacat ccgggacgag gccgccgggt cgcccgcctt cgcggcgctg cgcgacgact
     9541 ggctggcgca gctccggcgg ctgctggagt gcggggcccg cgagctggcg tggaagtcgg
     9601 gcgaccgggc cgcgtggccg acattcgacg agtacctgga aaacgccgac aactacggct
     9661 cggcctgggt caacgtctcg cactggatcg tgcacgccga ccagagcgtc ctcgaccaca
     9721 tcggcgaact gcaggccgcg agccgggacg tccagcaggt gctgcggctg ctcaacgatc
     9781 tcgccaccta cgagcgggac gtcacctggg gcgacctgaa cgcgcagatg ctcggggtgg
     9841 aacgtgccca gatcaccacg cggatcgacg agatcgtggc gcgctgccgc gaccacctcc
     9901 ggccgctgcg gcgcgactgc cccgaggcgg cggcctacct cgaacggcag atcggcttca
     9961 gtacgggctt ctacgagctg agcgactact gggggtcgct gtgaccgtcg aggaggtggg
    10021 tccggaggcg gccgaggccg ccgatcccga ccccgacgat cttcgcgcgg ccgccggcgc
    10081 gctggtggcc gatctcgtga accatccgtg ggggcggtcg tccccgtccg tctacgagac
    10141 cgggcggctg gtgagcctgg ccccgtggct gaccggggac tccgggagga tccgcttcct
    10201 tctcgacacg cagcggcccg acggcggctg gggaccgccc gatccgggat acgcgctcgt
    10261 cccgaccctg agcgcgaccg aggcgctgct gtccgtgctc gccccggagg ggcgccgctg
    10321 gccggccggc ctctccgtcg ccgaggtggt ccgcggcgcc gggcgcgccc tgcgggccct
    10381 cgcgcggcgg ctcggcggcg ccaccgcggc cgacttcccg gacatgccgg ccatcgagca
    10441 catcaccccg gccctcatcg aggcgatcaa caggcacctc gaccggctcc gcgacgaccc
    10501 cgtcctcacc gcctggtgga cgggcggacg gctggccccg cccgccggaa tggacggggc
    10561 gttcatcgcc gccgccaggg cccatctgga gaacggcggc gccgtgccgc tgaaggtcca
    10621 gcacgccctg gaggtcgcgg gggcgtcggc gcgccgggcc ggtgcggtcc gtcccgtgcc
    10681 cctgcctgca ccgacacgcc ccatccgcga gctctccgtg gcgaacggac cgggacggtt
    10741 cgcgaccgtc ggcgcctcca ccgccgccac cgccgcgtgg ctcggcggcc ccgacatcga
    10801 caggggcggc gaccaggcgg cgcggcgcta cctggaggcg gccgtcgagc agcacggcgg
    10861 tccggttccc gtcgccgtcc cggtgaccaa cttcgagcgc gggtgggtgc tgggctggct
    10921 ggcccgcgcc gggctcgcgc cggcggtccc gccggagctg atcgcccaga tgcgggcgtc
    10981 gctcggtgag aacggcgcgc cgggcgggac cggcctgccc ccggacgccg acaccagttc
    11041 cggcgtgctg tacgcgttgt cgcttctcgg caaaccccac ccgcccgacc tgctctggaa
    11101 gtacgaaacg accacgcatt tctgtagctg gcctggtgag aacggccggt ccgtcacgac
    11161 caacgcgcac gtccttgagg cgttcggcca ttacctggag tgcggcggcg cgggaccggc
    11221 cggccgttac gcggcgagcg cgcgaaaagc ggcgtcctgg ctcatcggcg agcagttgga
    11281 cgacggccgc tgggaggacc ggtggcatgc gtcgccgctc tacgcgaccg cttgtgcagc
    11341 cctggccctg aacgagttcg ggggtccgga atcggcgggc gccgtgaatc ggtccgtcga
    11401 gtgggtgctg cgggagcagc gttcggacgg ctcctgggga cgctggtgcg ggaccgccga
    11461 ggaaacggcc tacgccgtcc acatcctgac cctggcccgc ccgtccggcg atgccgcacc
    11521 tgactcggcg gcgcggaagg cagtggagcg ggcggtccgg cggggcgacg cccacctcag
    11581 agcggccctg cggagcacgc ccggcgccct gaccggcggt ccgggggacg ttgactccgg
    11641 caagccgcct ctctggcacg ataaagacct atatcgccca acgacgatcg tgtgggcggc
    11701 ggtcctgggc gcccttcatc tggcacggcg tgacacgagt gtttcagcgc ggtgaatttc
    11761 accaccctgt cagagtgtga cctgcttgta cgcctgagcc ggaaaccatt caccttgagt
    11821 gggtttggtg gcgttggtaa ggttcatcgg tgcgttgccg atcacacggc atagcgctac
    11881 ccgcactcac cgccaccagt gtctcgcagc cgggccccaa gacctcgcat tgcaggcacc
    11941 ttgacaattg ttggggcgat cataatgcgt ttccgcaact cacggctgcg gaccaagatt
    12001 gcggccctgc tggtctcgtt gacagcgctg tgggccttcg ccgcctgggt gacgttgcgc
    12061 gaaggcgtga acctgctctt cgtgagcacc ctggacagcg tcgtggcccc gagcgacccg
    12121 ctgctcgtcg aactgcagca agagcgccgc ctcaccgtga ccatgctcgc gtccggccaa
    12181 cggcggcccg acgtcctcgc cgcccagcgc gcccgcaccg acaaggagcg ggccatcgtc
    12241 gtcgagaagg ccggcagcgg ctcggtccgc cgcgccgccg acgacgagat ggaccagcgg
    12301 ctcgacgcga tggtccggct gctcggccgg ctcgacggcg accgccgttc gatcgacgcg
    12361 ggcgccttcg accgccggca catcatcgac gtctactccg acaccatcga gtcgatcttc
    12421 cacatgtacg acgggacgac gacgctcgac gacaggggct tcacctccga cctgcgcgcg
    12481 gagatcgccg tcaaccggtc ctgggagctg ctgtcccagg aggacgcgct cgtcgccggc
    12541 gtcctggcgt ccggccggat caccccggtc gaccagatgg acatcgccaa ggccgtcggc
    12601 gcccggcgcc tcaactacga gcgcgccctg gtcgacctgg agggcgcgga ccggcaggcc
    12661 tggaacgagc tgaacgccaa caagcggctc accaccgtca gcgccctgga ggacgtgctc
    12721 ctccagcgga cgaagacgca cggcccccgc atgagcgccg agcagtggcg cggcgcgacc
    12781 gatcccgcgc tcgcccagat gcgcaagacc atccaggacg ccggagaccg gctggtggag
    12841 cgcgccactc ccatcgccac ctgggtcatc atccggctgc tgctcgccgg tggactcggc
    12901 ctcctcgcgg tcatcgcgtc catcgtcgtg tcgatcacca cggcgcgcgc cctcgtccgg
    12961 cagctggagc ggctgcgcgg cgccgcgtgg gagctcgccg agcagcggct gcccggcgtc
    13021 gtggagcggc tcgggcacgg cgagaaggtg gacgtcgagg tcgaggcgcc gccgctgcgg
    13081 ttcggcaacg acgagatcgg tcaggtgggc cgcgcgttca acgccgtcca ggagaccgcg
    13141 atccgcaccg ccgtcgagca ggcggaactg cgccgcggca tccgggacgt cctgctgagc
    13201 ctggcccgcc gcacccagac gctggtgcac cggcagctca ccatgctgga cacgatggag
    13261 cgccgccgcg acatcgagac caaggagctg gaggagctgt tccggctcga ccacctcgcg
    13321 acccgcatgc ggcgcaacgc cgagaacctc atcgtgctct ccggcgccct cccggcccga
    13381 ggctggcgca actccgtccc gatggtggac gtcgtacgcg ccgccgtcgg cgaggtcgag
    13441 gactacaccc gcgtcaccgt cctgccgttc ggcccggtcg agctggccgg acgctcggtc
    13501 ggtgacgtca cccacctgct ggccgagctg atcgagaacg ccgtgtcgtt ctccccgccc
    13561 gacaccatcg tgcaggtcgg cgggcacctg gtcgccagcg gcttcgccat cgacatcgag
    13621 gaccgcgggc tcggcatgac cgacgagaag ctcgccgaga tcaacgggcg gatcgccgac
    13681 ccgcccgact tcaacctgca gagctcggtc cagctcggcc tgttcgtggt cagcaagctc
    13741 gccgagcgct acaacctgca ggtctcgctg aagcggtccg cctacggcgg cacgaccgcg
    13801 gtcgtcgtga tccccaggga gctgatcgtc gagcagggcc cggcgcaggt cccggccggc
    13861 accaccacca cgaacggcct ggaggtccgg cgcccggccg ccgtcggcgc cgcgtccggc
    13921 gccgcgatcc gctccgcctc ccccacggtg acgctccccc cggcgggcac cggaccgcag
    13981 cccgtcggcc ccgccctcgt ggcggtcccc ccgccggccg cggagccgct gcccgtccgg
    14041 cccgccggcg gcaccgcccc cgaaacagag cccgaggccg ccacgcccgc ggggcacggc
    14101 gaccccgcgg acggcgcacg tcccgacccc atcgagccgg aggacctgcc acccgtgccc
    14161 gacatctcca ccacaccgtc cggtctcccc gtccgagtgc cgcaggcgaa cctggccgaa
    14221 cccctgcgca ccgatgagcc cgtcgccgcc gacgagcagg acgagcagga ggacccgggc
    14281 cgctcccccg aggagatcca gcggatcatg ggttcctacc agcgcggcac ccagcggggc
    14341 cgcgtcgacg cggcggaggc cctcggcacc aacgcagcgg aaggcgaggc agagcagtga
    14401 cgcagaagac cggttcctcc tccgatctgg gctggctgct ggacgacctg gtccaccggc
    14461 tgccgcacgc ccgcagcgcg gtcgtgctct cggcggacgg cctgctcatg gcgtcctccg
    14521 agggcatgac gcaggacgac ggcgagcacc tcgccgccgt cgccgccggc atccagagcc
    14581 tcgccaaggg cgccgggacc cgcttcggcg gcgggcccgt ccgccagacg atcgtcgaga
    14641 tggcctcggc gttcctgctg gtcacggtcg ccggcaaggg cgcctgcctt gccgtcctgg
    14701 ccagcgagga ggtcgacgtc ggcctcaccg cctacgagat ggcgatgctc gtcacggcca
    14761 tgggccacca cctcacctcg ccgtcgcgtt cggagtccgc gcaggagggg cgcccggcat
    14821 gatgcccccc gaggatccag cccaggagcc ctgggcggac gaggccgtga cgcgcccgcc
    14881 cctcagcgac cggttcctgg acgagcacgc gggcccgatg gtgcggccgt acgtgatgac
    14941 cagcggccgc atcgagccga cccgcggcaa gttcgacctc atcaccctgg tggtggcggt
    15001 cggagcggag ccggagggcg cgatcgccct cggacccgag cacctgtcca tcatccggct
    15061 ctgccagtcg gtgatgtcgg tggccgagat caccggccat ctcgacctcc ccgtggcgac
    15121 cgtgcgggtg atgctcggcg acctgctcga caagggcttc gtctccctgc aggaacccga
    15181 accggaggcg gacatgcacg acatcaggct ctacaaggcg gtgatcgatg gtctccgggc
    15241 cctctaggcg cgacgtccgc gcccgccggc tccccaccgc ggtcaagatc gtgatcgcgg
    15301 gcggattcgg ggtcggcaag accacgatgg tgggcacggt ctcggagacc cgccccctgc
    15361 gcaccgagga gttgctgacc gacgagagcg tcggcatcga cgacatctcc ggggtggaac
    15421 gcaagcagac caccacggtc gcgatggact tcggccgcat cacgatgcgc aacgagtacg
    15481 tcctctacct gttcggtacc cccggccagg agcgcttctg gttcatgtgg gacgaggtct
    15541 cgctcggcgc gctcggcgcc gtcgtcctcg ccgacacccg ccgcctgtcg gactgcttcc
    15601 cgtccgtcga ctacttcgag cgccgcggca ccccgttcat cgtcgccgtg aactgcttcg
    15661 agggcgccca gcgctacgac ctgacggaga tccagatggc cctgaacctg ggccccaagg
    15721 tccccgtcat gctctgcgac gcccgcagcc tgggctcctg caaagaggtc ctcatcgacc
    15781 tcgtcctcca cgccatgaaa acccgcggcc tcacagaaga accagaaccc caaaaagcct
    15841 gagacaccga agcggggccg tgtgccgccg gcgctgagcc ggcggcacac ggccccgctt
    15901 cgatttccgc gcccccacgc agtgacggga gccgcgcgac ttcgcacccg ccgcacccac
    15961 gggcgcaccg acccaagcga ccgccgcaac cacgcaacaa ccacaatggc cgcgatcgcg
    16021 tccgaaggca gattcgagcg aagcaagaat ctgatcgcgc agcgagccgc aaggcgagcc
    16081 ggagcgatgc cagcgatcgc cgcagtgccc gacgatggag ggccctccgg gcccgaagga
    16141 ggagggcact gcagtaaaca cagctagccg gtacggctca ctacatagtc gcagaggttg
    16201 gtgaaggcgt cgcgggcggg gatctcgggg agggtgagga gttcggtgcg ggcgtcctcg
    16261 gcccagcggc ggaggtcggc gcgggcgcgg tccatggcgg ggtgggcgcg caggagggtg
    16321 agggcctcgg cgtggagggc gtcgtcggtg aggtcctggg tgaggagctc gcggaggcgg
    16381 gcgtcgtcgg ggccggagcc gatgccggcg aggacgtggt gcatggggag ggtgcggatg
    16441 ccctcgcgca ggtcggtgcc gggggtcttg ccggactcct cggtctcgga gtcgatgtcg
    16501 aggatgtcgt cggacagctg gaaggcgatg ccgatcttct cgcaggcgga ggtgaccgtg
    16561 tcgacgacgt gggcgggggc gcccgagagc agggcgccga actggccgga gacggcgatc
    16621 agggacgcgg tcttgtcggc gacgacctgg aggtagtgct tgaggtggtc ggcgtcctcg
    16681 ccggggccga cggtctcctg gatctggccg cggaccaggc gggcgaacgc gcgggcctgg
    16741 atgcggacgg cctcggggcc gaggtcggcg agcaggtcgg acgcgcgggc gaacaggtag
    16801 tcgccggtga ggatggcgac ggtgttcgtc cagcgggagt tggcggactg ctggccgcgg
    16861 cggacggtgg cctcgtccat gacgtcgtcg tggtagaggg tgccgaggtg ggtgagctcg
    16921 acgacgacgg cggccgggac gacgccgggc gccgccgggt cgccgaagtg ggaggccagc
    16981 agcaccagca tcggccggaa ccgcttgccg cccgcctcga cgaggtgctg cgaggcctcg
    17041 gtcagcagcg ggtcctcgcc ccggacgcag tcgagcagca gggactcgac ggcggcgagg
    17101 cgctccttgg cgtcggacgc gagcgcggcg tcgacgggaa gcccgaacgg gccggtctcc
    17161 tggatggccg gcccgccgga cttctcagcg aatgggttgc tcacccaaga ctccctaccg
    17221 gacgaacatg tgggtcgtgg cctgccccgc gaggtccaga acgggctgcg ggatcacgcc
    17281 gagtaccaca gtagccgtca ctccgaccgc gaccgcgacc gcggtcgccg ggccggccac
    17341 cacgaccggg ccctcggcgt ccggctcgct gaagaacatg acgacgatca cacggacgta
    17401 gaagaacgcg gcgaccgcgg aggagagcac ggcgacgatc accaggggtg tcgcaccgct
    17461 ctcgacggca gccttgaaca ccgcgaactt cccggtgaaa ccgctggtca gcggaatgcc
    17521 ggcgaagccc aggaggaaga aggcgaagac gcccgcgacc accggggacc gcttgccgag
    17581 gccggcccac cgcgacaggt ggccggcctc gccgcccgcg tcccgcacca tcgtcacgac
    17641 ggcgaacgcg ccgatcgagg tgaagccgta ggcgaccagg tagaacatcg tgctggacag
    17701 gccgtccgcc gagctggcga tcacgcccat gagcaggaag cccgcgtgcg cgatcgagga
    17761 gtaggccagc atccgcttga tgtcggtctg cgtgatcgcg atgatcgacc cggcgaccat
    17821 ggtgagaatg gccacacccc acatgagggg ccgccagtcc cacttcagcg tctcgaacgc
    17881 gacgtagtag acgcgcagga tcccgccgaa cgcggcgacg acggtgcagg acgccatcag
    17941 cgccgtgatg ggggtgggag cgccctggta gacgtccggc ttccacatgt ggaacgggac
    18001 gccgccgagc ttgaacagca gcccgaccga cagcagcgcg acgcccgcga ggagcagggt
    18061 ctcgctgccc gcgtccttgc cgatctgtac ggagatgtcc gacagccgga cggacccggc
    18121 gtacccgtac agcagcgccg ccccgtacag gaagaacgcc gaggagaacg cgccgagcag
    18181 gaagtacttg accgccgcct cctgcgagag gaggcgccgc cggcgggcca gcccgcacag
    18241 caggtacagc ggcagcgaca tgacctccag cgccacgaac atggtgagca ggtcgttggc
    18301 cgccgggaac atcaccatgc cgccgacggc gaacatcatc agcgggaaca cctcggtctg
    18361 ggtgaacccc gcctcggtgg tgcgctgctc ggcctcgctg ccgggcaggg cggacgcctg
    18421 cgcggcgaag tggccgccgg ccctgccctc cccccgctcg gcgatgagca ggaggctgac
    18481 cagggccagc accaggatgg tgccctggat gaacagcgtg gggccgtcca cgcccagagc
    18541 gccctcggcg gcgacgtggt gcgggttgtc gcgccatgcc agcgcgatcg tccagccgaa
    18601 cgcgcccgcg aggccgagga acgcgagcgg cacctgcacg tagtagcgcg cgctccggcc
    18661 gacgaacgcc tcgacgagca cgcccacgac ggcgacgccg aggaccagga gcagcggggc
    18721 gatctgcccg tactcgatgt gcggcgcggg gatgtcaccc ccctgcgcga ggaccgcgct
    18781 cacctgactg gtggtgctca tggacgggct ccgttctcgg cgacgttacc ggtgatgtcc
    18841 ggcgccgggt cgtgctcgcc gacccgggcc agcgtgtggc ccaccgacgg gttgatcacg
    18901 tgcagcaccg gctgcgggaa caggcccatc gccacgatga tcgcgatgat cggcgcgagg
    18961 gcccacttct cccgggcgga caggtccttc atgccctcga ccgcgggcgt cttggggccg
    19021 cccatggtcc gctggtacat ccacaggacg tagatcgcgg cgagcacgac gccgctcacc
    19081 gcgagcgcgc ccgcccactc gtaccggctg aacgtcccga cgatgaccag gaactccgat
    19141 acgaacgtgg acaggccggg cagcgacagc gcggacaggc cggcgaccag gaacatcccc
    19201 gcgaggacgg gggcgacctt ctggaccccg ccgaagtcgg agatccgcgc cgaccgccgc
    19261 cggacgatca tgaagccgac gacgaggaac agcgcgccgg tggagaaccc gtggttcacc
    19321 atgtagagcg cggcgccgga ctggccctgc gacgtcatcg cgaagatgcc gaggacgatg
    19381 aacccgaagt gcgacaccga cgtgtaggcg atgaggcgct tcatgtcgac ctggccgatc
    19441 gcgaggaccg cgccgtagat gatgctgagc accgcgaacg ccagcacgac cggggtcgcc
    19501 cacttggccg cgccggggaa cagctccagg cagaaccgga gcatgccgta ggtgccgacc
    19561 ttgtccagga cgccgacgat cagcaccagc gcgcccgccg gggactgctg cgccgcgtcc
    19621 ggcagccagg tgtgcaccgg caccatcggc gccttgatcg cgaacgcgac gaagaagccg
    19681 aggaacagcc acttggccgt cgtcgggtcg atgttcatct tcgacagctc gtcgaacatg
    19741 aacgtgccgt gcccgaggcc gccctcgtcg accgaccggc tcgacagcgg gtacagccag
    19801 atgacggcga cgagcatcag cagcccgccg aacagcgagt acagcaggaa cttcaccgcg
    19861 gcgtaggagc gctgcgcgcc gccgtagtac ccgatgatga agtacaccgg gatgagcatc
    19921 gcctcgaaga agacgtagaa caggaacacg tccgtcgcgg cgaacacgcc gatcatggcc
    19981 gcttccatcg tcagcagcag cgcgaagtag gtcttcaccg accgctgcgt tccgcccccg
    20041 tggccacgcc ccgcctcgtc ccgggccggg gcgtccacgc cgccggaccg gtcggcctcg
    20101 ttccacgacg ccagcatgac cagcgggacg aggatcaccg acagcaggat cagcaccagc
    20161 gcgacgccgt cgacgcccac cgcccagtgg actccgaact ccttgatcca ccagtacttc
    20221 tcggtgaact ggaaccgcgc accgcccgcg tcgaagcccg ccgccatgac cccggtgagg
    20281 accgcgacga cgagggagac gccgagcgag aactgcttgg ccagcgcctc ccgctcgcgc
    20341 gggatggcgg tgagcagcac cgcgcccgcc agtggcagcg cgatgaggac gctcagccag
    20401 ggaaagtcgc tcatgacacg ttcaccacca ggagcgccgc gaccacgagg gccgcgccgc
    20461 ccagcatcga gagggcgtag gagcgggcga agccggtctg gacccgccgg agccggccgg
    20521 agctgccgcc gacaccggcg gccgtcccgt tgacggcgcc gtcgacgccg cgcccgtcga
    20581 accagaccgc gagccgggtc agccactggc cgggacgcat cagcagcgac tcgttgagcg
    20641 cgtcgccgta gaggtccttg cgggccgcga cggtgacgaa cgagcccttg ggcgcctcgc
    20701 gcggcacctt gcgggcgccg tactgcatcc aggcgatccc ggcgccgacg atcatcagga
    20761 cgaaggtggc ggcgccgggc gcggtgagcc acttgaactc gtgcgcgtgc tcgggcgccc
    20821 cgacgaccgg ttcgaggaac tcggggaagc tgccgaggat caggaacccg cccgcgaaga
    20881 cggagccgac cgcgagcagc atcagcggcc aggtcatgac ggccggcgac tcgtgcgggt
    20941 ggacgtcgtc ctcccagcgc ttctcgccga agaacgtcat gaacatgacc cgcgacatgt
    21001 agtaggcggt gatcccggcg ccgatcagcg cgcaggagcc gaggatcagc ccggacgtgc
    21061 cgcccttgtc gtaggcggcc tcgatgatgc cgtccttcgt gaaccagccg gacaggccgg
    21121 ggaacccgat gatggcgagg tacccgagcc cgaacgtcac gtaggtgatc atcatgaccg
    21181 tgcgcagcgc gccgtagtgg cgcatgttca cgtcgtcctt catgccgtgc atgacggagc
    21241 cggcgccgag gaacaggccg gccttgaaga agccgtgcgc gacgaggtgc gcgatggcga
    21301 acacgtaacc cgccgggccg agcccggcgg ccagcaccat gtagccgatc tgcgacatcg
    21361 tcgacccggc gagggccttc ttgatgtcgt ccttgccgca accgatgatc gcaccggcga
    21421 gcagcgtggc cgcgccgacg atcgtcacca ccagctgcgc ggtctcggac atctcgaaga
    21481 tcggcccgga ccggacgatc aggtagacgc ccgcggtcac catcgtggcg gcgtggatca
    21541 gggccgacac cggggtcggg ccctccatcg cgtccagcag ccacgactgc agcgggagct
    21601 gcgcggactt gccgcacgcg ccgaccagga gcagcagccc gatggccgtc gcggtgccgg
    21661 tgccgagctt ggaggcgagc cccacgtgct cggcgccggt gccgaggacc gagccgaagt
    21721 cgatggtgcc gaacgaggcg aagatcagcg cgatcgcgat gatcagcccc atgtcgccga
    21781 cgcggttgac gacgaacgcc ttcttcgcgg cggtcgcggc ggtcggcttg tgctgccaga
    21841 acccgatcag caggtaggag gcgagtccga cgccctccca gccgaggaac aggatcagga
    21901 agttgcctcc cagcaccagc agcagcatcg ccgccaggaa caggttcagg taggcgaaga
    21961 accggcgccg gtcggggtcc tcggccatgt agccgatgga gtagatgtgg atgagcgagc
    22021 ccaccccggt gatcagcagg acgaaggtga tggacagcgg gtccaccagc aggtccatgc
    22081 cgaccttgaa cgtgccgacg tcgatgaagt cccacaggtg cagggtgcgg cgccgggtct
    22141 cggcgtcgta cccgatcatc tgggcgaaca tcgcggcgcc caccgcgaac gacgccaccg
    22201 acatcgcggc gccgagcagg tggccccact tgtcggttcg ccgtcccccc agcaggagga
    22261 tcgcggcgcc cgcgagcggg agcgcgacga ggagccagga cgcggcctgg atgccttccg
    22321 ctttcatccc tggcctctca gtacttcagc aggttcgcgt cgtcgaccga cgaggacctg
    22381 cgggtccgga agatggtcat gatgatcgcc agacccacca cgacctccgc cgcggccacc
    22441 accatcacga agaaggcgat gatctggccg tccaggttgc cgtgcatacg ggagaacgag
    22501 acgaacgcca ggttcgtcgc gttcagcatc agctcgacgc acatgaacac cacgatggcg
    22561 ttgcggcgca cgaggacgcc cagcgctccg atggtgaaca ggatcgccga gagcgccagg
    22621 taatgccctg ggctcattct cctgcctcgc cttcactcgc gccgccgcca gcggcgggcg
    22681 tccccgactt gaccgagcgc gcctcggcgt ccgtgtcgcg aacgtcctcg gtgaccgcct
    22741 tgaccgcggc cacgtcccgt tcgagggcct cctcctcgga gccgccgtac aggtcggcgt
    22801 gccgctccgc ggtgtcggtg cgggccgcga tgaccgggtt gaccgacagc tccgagggcg
    22861 tcccgtcggg cagcagcgcc ggcatgtcga cggcgttgtg ccgggcgtag gtgccgggac
    22921 ccggcagcgg gcccgggtgg gagccggaca ggaaccgctg ccgcgacagg tccttctgcg
    22981 tcggcttcgg ctcggtgcgc tcccggtgcg ccagcaccat cgcgcccagc gccgcggtga
    23041 tcagcagggc gctggtcgcc tcgaacgcga acacgtactt ggagaacagc agccgggcca
    23101 gcccgacgat gttgccctcg gagttggcct gggtcagccc ggccgagccg ccgagcgcgg
    23161 cgttgccgac cccgaccgac agcaggacga ggaagccgat cgcggcgagc accgcccaga
    23221 accgctggcc ccggatcgtc tccaccagcg agtcggtgga actgaccccg acgagcatca
    23281 gcacgaacag gaacagcatc agcaccgcgc cggtgtagac gatcacctgc acgaacgcca
    23341 ggaagggcgc gttctggatc gcgtacagcg cggccaggca gagcatcacg gtcgccagca
    23401 gcagcgccga gtgcaccgcc ttccgcatga agatcatgcc gagcgcggcg agcaccgaga
    23461 cgatcgccag cagccagaag aagaacggct cgccggactg cttgtcggcg acctcggcgg
    23521 cgagcacgtg cgcgctcgcg acggagccgg tcacttgccc tcaccgccct tgcgcgcctt
    23581 ctcgcgcctg gccttctcgc gctcggcggc ctggtcggcg ccggcgcgcc cgccgccctc
    23641 ggcggggacc ttcggagccg aaggcgttcc ggaggacggc gactgctcgc tctcctggag
    23701 gccgaggcgg tagtagtcct cctcggtgtc gccgagccgc atctcgtgcg ggggcgtctc
    23761 catgccctcg cgcagcggcg ccagcagcat ctccttggtg tagatgaggc tctcgcggct
    23821 gtcgtcggcg agctcgtact cgttggtcat cgtgagcgcc cgggtcgggc acgcctcgat
    23881 gcacagcccg cacaggatgc accgcagata gttgatctgg taggtgcggc cgtagcgctc
    23941 gccgggcgag taccgctcct ccgcggtgtt gtcggcgccc tcgacgaaga tggcgtccgc
    24001 ggggcacgcc cacgcgcaca gctcgcagcc gatgcacttc tccaggccgt ccggccaccg
    24061 gttcagctgg tgccgcccgt ggaagcgagg agccgtcggc ttcttcacct cggggtactg
    24121 gacggtctcg ctcttcatga acatctggtg gaacgagacc ccgaacccct tgaccgggtt
    24181 caggaaatca gtgagtccca ctggtgacct cctcggaggg ggtttcgatc gtgaccggcc
    24241 ggtccggctc gcgggcgcgg ccgtggtagt ggggcgcgtc catcggcggt accgggaacc
    24301 cgcccgccga cgggtcggtg cgcggccccg gcgtcgcccc cgggacgatc tccttgtcgt
    24361 cctcgcggcc gcgggccatc tcccagatca ccgtggcgac cagcacgatc gcggcgacca
    24421 cggcggcggc gatgaacagc tgccgcatct cgtagccgtc gttgcgcagg gcgcggatcg
    24481 tcgcgaccag caggatccag ccgagcgaga agggcatcag caccttccag ccgagcttca
    24541 tcagctggtc gtagcgcacg cgcggcagcg tgccgcgcag ccagatgaag aagaagatga
    24601 acaggaagat cttgatcagg aaccacagca ccggccacca gccggagttg gcgcccgccc
    24661 acaccgtgga gatcggagcg ggggcgcgcc agccgccgag gaacagggtg gtggccaggg
    24721 ccgacagcgt cgcgaggttg atgtactccg cgaggaagaa catcgcgaac ttcagcgacg
    24781 agtactcggt gtggaagccg ccgaccagct cgccctcgcc ctcggggagg tcgaacggga
    24841 tgcggttcga ctcgcccatc atcgtgatga cgtacacgac gaacgacggc gcgagcagca
    24901 ccacgaacca cttgtcgtgc tgcgccgcga cgatctccga ggtggacatc gagcccgcga
    24961 acatgaacac ggccacgaac gacaggccca tcgcgatctc gtaggagatc atctgcgcgg
    25021 acgagcgcag cccgccgagc agcgagtacg gcgacatcga ggaccagccg gccagcacga
    25081 tgccgtagat cgccatcgag gacatcgcga ggacgagcag caccgcgacc ggaaggtcgg
    25141 tgccctgcag cgccgtctgg tgcccgaaga tcgagaccgt cggcccgaac gggatgatga
    25201 tgaaggagat gaacgcgggc accgccgcca tcaccggcgc caggacgaac acgatcttgt
    25261 cgacctggcg ggggacgatg tcctccttca gcgccagctt gacgccgtcg gcgagaccct
    25321 gcagcaggcc gaagggcccg gcgcggttgg gaccgacgcg cagctgcatc cggccgatga
    25381 cgcgccgctc gatccacatc gtcatcagca cggtgacgac gaggaacacg aagatggcga
    25441 ggaccttgcc gccgatcagc caccacgggt ccgacccgaa gtcctgcagt cgcgggtcgg
    25501 gcgccggcgc cgctgccagg gagctcattc gatgcctcca gcgttctcgg tcgcggtcgc
    25561 gggcaccgcg cccgcgatct tgacgacgcc tcccgcgacc gcgccgaggt cccggtgcag
    25621 ggcgcagccc gccgagttcg tcggcagcca caccacccgg tcgggcaggt cgggggtgat
    25681 ctccagcggg agcgtgacct cgccgcgcgg gcccgacacc gtcaccgcgc cggtggcgcc
    25741 gatctccgcg gccgtcgcgg gcgacagccg ggcggcggcg ggcttggcgg tgcccgcgag
    25801 gaacggctcg ccgtcctgga ggcggccccg gtcgaggagc agccgccagg tcgcgaggag
    25861 ggcctcgccc tgctcggggt gcggcgccag gccctgcgcg acgttcggcg cgtccgggcg
    25921 ctcgcccctg tgggcgccga ggccggccat ctcgcggcgg gcggcctccg ggcccggcag
    25981 gcccaggtgg acgtccatct cgtcggccag cgcgtccagc acccgcaggt cggacatccg
    26041 cccggcggac ttgagcacga cgtcgaacgg gcggccgcgg ccctcccagt cgacgaacgt
    26101 cccggccttc tccgccaccg ccgcgaccgg caggacgacg tcggcgcggt cggtgaccgc
    26161 gctcggccgc tgctccaggc tcaccacgaa cggggtggcc tccagcgccc gcagcatcgc
    26221 ctccgggtcg gccaggtcgt aggggtcgac accgccgacg agcagcgcgc cgcgccgccc
    26281 cgcggccgcc gccgcgatga tgccggccgt gtcctcaccg ggaccggcgg gcaggtcggc
    26341 gacgccccac gtgcgggcga cctcggcgcg cgcgtccgcg tcggtgaccg gacggccgat
    26401 cggcagcagc ccgggcagcg ccccggcctc gatcgcaccg cgctccccgg cccggcgcgg
    26461 cacccaggcc agccgggcgc cggtcgcctg cgccacccgg gtcgccgacg tcagcgcgcc
    26521 cgggctggtg gcgagccgct cgccgacgag gatgacggcg ccgggggtct ccagcagcgt
    26581 gcggatgtct gtgctggcgt catccccgat gccggcggcg tccccgatga gggagccgag
    26641 gacctcgccc tccgagccgg gaagcgtcgg cagcagcgtg ccgccgacct tcgccagccc
    26701 gcgcgtcatg aacggggccg cggcgaacac cttcaggccg ttcttgcggt gcgccttgcg
    26761 gagccgcagg aagacgatcg gcgactcctc ctcgggctcg aaccccgcga gcaggacgac
    26821 cggcgccttc tccaggtcgg cgtaggtcac ctcgatgggg tggcccgcga cggacgaggc
    26881 gaggaaccgc gactcctcct ccgacagcgg ccgggcccgg aagtcgacgt cgttggtgcc
    26941 gagcgcgatc cgggcgaact tggcgtaggc gtaggcgtcc tcaagggtga cgcggccgcc
    27001 ggtcaggacg ccggccgagc cgcgcgccgc cgccaggccg cgcgccgcga tggtgagcgc
    27061 ctcgggccag gacgccggct ccagctcgcc gtcctcgccc cgcacgagcg gctgcgcgag
    27121 gcgctcgggc tgcgtcccgt aggtgaacgc ccagcggccc ttgtc
//
