LOCUS       NZ_BMRD01000020        21541 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence20, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000020
VERSION     NZ_BMRD01000020.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 181258)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 159717
            Orig. end                         :: 181258
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21541
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="2"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..21541
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21541
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20000:>21541](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..>21541
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            complement(1282..2865)
                     /locus_tag="IEZ14_RS34200"
                     /old_locus_tag="GCM10010177_69070"
     CDS             complement(1282..2865)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0051082 - unfolded protein binding
                     [Evidence IEA]"
                     /GO_function="GO:0140662 - ATP-dependent protein folding
                     chaperone [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657911.1"
                     /locus_tag="IEZ14_RS34200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69070"
                     /product="Hsp70 family protein"
                     /protein_id="WP_179836027.1"
                     /transl_table=11
                     /translation="MAVYGIDLGTTYSCIASIDDVGRPAVQRNLEGTDTTPSVVFFESG
                     ENVVVGQTAKDTAVLEPDKVVSLIKRDMGRDVTRPVHGIDFTPEEVSAFILLKLATDAR
                     TTTGEEARDVVITVPAYFGVAERDATRKAGRIAGLNVIDIVSEPIAAAITYGVLNPESD
                     RTILVYDLGGGTFDTTVIALREGHIEVVCTDGDHELGGADWDARLVEHLAERFRAEHPG
                     AGDPLDDRQTEQQLRRDAEDAKKALTTRTSHTVRVMHGGRVASVEVTREKLEELTKDLL
                     DRTVEITGRTLATAAEKGVEDYDDLVLVGGSTKMPVVAARLQTELGLAPRLQDPDLAVA
                     KGAALYAFEETYRRLVREGAAERAEEMANRAGLSAEQQRQIAGRQIRTVASHAFGIVVV
                     DRDTGAESVAHLVHANDELPAAKTEDFFTVYDDQASADIRVMEQAGVVESADLIDNTEI
                     ATGEIRVPPGKKAGWPIGVTFALDSSGLLNVTAMEKETGERLELKVDVGGMSEEEVERS
                     RKALSRVQVS"
     gene            complement(2871..3524)
                     /gene="grpE"
                     /locus_tag="IEZ14_RS34205"
                     /old_locus_tag="GCM10010177_69080"
     CDS             complement(2871..3524)
                     /GO_function="GO:0000774 - adenyl-nucleotide exchange
                     factor activity [Evidence IEA]"
                     /GO_function="GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_function="GO:0051087 - protein-folding chaperone
                     binding [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /gene="grpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634290.1"
                     /locus_tag="IEZ14_RS34205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69080"
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="WP_229810600.1"
                     /transl_table=11
                     /translation="MSRDGEPPVSEASGAGPEPGRAGNAGNAGAGDAGAVLHAEVRDAL
                     AGLTARLDRERERAEHREAVIDRLHEENQRLRRGELQAMLEPVRAALYRLHDQARRESD
                     RLRAPDLTEAPDPRRTAVLLAAVADDVADALARLGVERFTVEPGAPYDASRHRPVAVTP
                     VDDPVADGTVTTVQSDGFEQSGKVLRKAAVSVGRLAEPAPAGEAAHNGQTTNSG"
     misc_feature    complement(3521..3534)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.91"
                     /tool="antismash"
     misc_feature    complement(3601..3617)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.17"
                     /tool="antismash"
     gene            3720..4361
                     /locus_tag="IEZ14_RS34210"
                     /old_locus_tag="GCM10010177_69100"
     CDS             3720..4361
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132133.1"
                     /locus_tag="IEZ14_RS34210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69100"
                     /product="ACT domain-containing protein"
                     /protein_id="WP_179838870.1"
                     /transl_table=11
                     /translation="MLLRIRVRLPDRPGSLGQVARTLGAAGADVVQMAVLERDNGRAMD
                     DFTVAWPAGADSERLAGGLGTVPGVEVVGIWPTAEPQGAFPDAAVIGQVAAVPERGLEI
                     LADAVPAILSADWAGLAELKGEDEAVLVHASAGGEPGAVLPELRPLRPRAFTAQDGTRF
                     AVCPLAAGGVALVVARTGAPPFHRTEVFRLEQLAGAANAVLHRVRGAAPL"
     gene            complement(4387..5304)
                     /locus_tag="IEZ14_RS34215"
                     /old_locus_tag="GCM10010177_69110"
     CDS             complement(4387..5304)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657908.1"
                     /locus_tag="IEZ14_RS34215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69110"
                     /product="carbohydrate kinase family protein"
                     /protein_id="WP_179836026.1"
                     /transl_table=11
                     /translation="MTVVTLGAHILDVLARPVEGIPDGQDTVVVEQIRVTAAGAAAGTA
                     VALARLGNEVVSVGAIGDDDLGDLLVTIMTREGVDVRGLVRRSADQTSASILPIRPDGG
                     RPSFHVPGANLTLTADAVGPGLLAAASAVHLGGPDVTFGLNDPAFFAVLAAAREAGTVV
                     TMDLLSNMPDLLDGAAAFLPHVDHFLPNGEQAALMTGEDDPEKAAAALLARGPGTVVVT
                     LGGDGSLVATAEGAHRLPALPVEVVDTTGCGDAYCAGFITGLTHGKDVLEAARWGTAAA
                     ATVAQGLGSDAGLTDLDAVLALLD"
     misc_feature    complement(5360..5378)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.17"
                     /tool="antismash"
     gene            5376..6020
                     /locus_tag="IEZ14_RS34220"
                     /old_locus_tag="GCM10010177_69120"
     CDS             5376..6020
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894109.1"
                     /locus_tag="IEZ14_RS34220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69120"
                     /product="class II aldolase/adducin family protein"
                     /protein_id="WP_179836025.1"
                     /transl_table=11
                     /translation="MLLRDERDALCGIGRRLAGTGLVTGASGNISVRSGDLVAVTPGGM
                     MLDRMEPADCPVVNIAGHWVDGDKAPSSETPMHLALYETTPAAAIVHTHSTYGAVVATT
                     MSELPPIHYNTLLLGGVVKVAEYATYGTPELAENVRAAMAGGKRAALMANHGGVTIGRD
                     LEEAYENARLLEWLCGVYVRARTIGEPRVLTEEELAKVVERGLAPPDFPRV"
     misc_feature    6022..6035
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.82"
                     /tool="antismash"
     gene            6056..6859
                     /locus_tag="IEZ14_RS34225"
                     /old_locus_tag="GCM10010177_69130"
     CDS             6056..6859
                     /EC_number="4.2.1.17"
                     /NRPS_PKS="Domain: ECH (11-227). E-value: 1.9e-46. Score:
                     150.3. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS34225_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF004519.0"
                     /locus_tag="IEZ14_RS34225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69130"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_179836024.1"
                     /transl_table=11
                     /translation="MPFVLVDRPRPNVALITLNRPERMNAMAFDVMVPFREALEEVSRD
                     NGTRVVVITGAGRGFCSGADLENPGNIPGIDGLTLPTIALRSMELLDDVVRAMRRVHQP
                     VIAAVNGPAIGGGLCLSLAADIRLGAETALFRAAGINNGLTASELGLSYLLPRAIGASR
                     AFELMLSGRDVEAAEAERIGLLSRVVPGDKLLDACYELAERIAGFSRPGTELTKRMLWS
                     SLDAASLDAHMGQEGLAQLYVRLTTHNFEEAIRARREHRPPDFQD"
     aSDomain        6089..6736
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS34225_ECH.1"
                     /evalue="1.90E-46"
                     /label="IEZ14_RS34225_ECH.1"
                     /locus_tag="IEZ14_RS34225"
                     /protein_end="227"
                     /protein_start="11"
                     /score="150.3"
                     /tool="antismash"
                     /translation="NVALITLNRPERMNAMAFDVMVPFREALEEVSRDNGTRVVVITGA
                     GRGFCSGADLENPGNIPGIDGLTLPTIALRSMELLDDVVRAMRRVHQPVIAAVNGPAIG
                     GGLCLSLAADIRLGAETALFRAAGINNGLTASELGLSYLLPRAIGASRAFELMLSGRDV
                     EAAEAERIGLLSRVVPGDKLLDACYELAERIAGFSRPGTELTKRMLWSSLDAA"
     gene            complement(6816..7889)
                     /locus_tag="IEZ14_RS41975"
                     /old_locus_tag="GCM10010177_69140"
     CDS             complement(6816..7889)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS41975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_69140"
                     /product="hypothetical protein"
                     /protein_id="WP_218935271.1"
                     /transl_table=11
                     /translation="MESVGRLWPRWAGYAAGAWTLGAVGVVLYWAGGGDAGSPLAGARA
                     AAWVIAACLGVGGIMAVSSVRGVGRQMPRWWPLTGLWTACALAGAGTFGFVMNALQLVF
                     DGTVDDWPRFGVEALCAVGAALLAGTALAYQRGTAGTCARCGRAHAEAGTVKAPAPVSP
                     APRAVRWAAYGGALGFAPYVAMKTTWAFGGSFAGIEGEQVVAEFERNGASGLVLTLERY
                     GLDFTTLSALAGVFLLMGLTHTWGQVFPRWAPPLAGRRVPRWLPLTPAWLGALTLGPYG
                     VVGSVAYLLPPVLGLGGLPHDGLISGWPGWTVAACGIGAFAAYGVALGAAAWSYQRRTR
                     PVCVSPGSPAAGAPSAP"
     gene            7983..8402
                     /locus_tag="IEZ14_RS34235"
                     /old_locus_tag="GCM10010177_69150"
     CDS             7983..8402
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634293.1"
                     /locus_tag="IEZ14_RS34235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69150"
                     /product="TIGR03668 family PPOX class F420-dependent
                     oxidoreductase"
                     /protein_id="WP_179836023.1"
                     /transl_table=11
                     /translation="MPKLAPDEARRLLTTVPVARLATVGEDARPHLVPVTFAVHRGAVY
                     TAVDHKPKSSRDLRRLANIRANPRVALLADHYEDDWDRLWWVRVDGHATVVDDPARMAD
                     PVRLLADRYPQYREHPPEGPVIAMTIEAWTGWSAS"
     gene            complement(8399..9196)
                     /locus_tag="IEZ14_RS34240"
                     /old_locus_tag="GCM10010177_69160"
     CDS             complement(8399..9196)
                     /NRPS_PKS="Domain: Abhydrolase_1 (22-175). E-value:
                     3.2e-20. Score: 64.7. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS34240_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="IEZ14_RS34240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69160"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_179836022.1"
                     /sec_met_domain="PF00561 (E-value: 2.9e-16, bitscore: 53.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.1e-20, bitscore:
                     66.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSETRFLDLPGGRLAYDDSGDGPLIVCLPSMLDLRSQYRFLRPLL
                     LDAGYRVVTVDQRGMGETSARWPEYGSTPLAHDLLALLKHLDAGPALVYGCSNGAAAAV
                     WVAAEAPELVKGLVLAAPFVRDGEAGFAQKLTVALMRVPGLALPLYLSYYPKWEPKPPA
                     DFAEHKAKLKANFKEPGRDKVIAEYLSMSHAESEARLDRVQAPTLVIMGTGDIDWPDPA
                     AEAAWVGQRLDGQVVLLDGAGHHPHVEFPEKVAEAVTTFQRSL"
     aSDomain        complement(8672..9130)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS34240_Abhydrolase_1.1"
                     /evalue="3.20E-20"
                     /label="IEZ14_RS34240_Abhydrolase_1.1"
                     /locus_tag="IEZ14_RS34240"
                     /protein_end="175"
                     /protein_start="22"
                     /score="64.7"
                     /tool="antismash"
                     /translation="PLIVCLPSMLDLRSQYRFLRPLLLDAGYRVVTVDQRGMGETSARW
                     PEYGSTPLAHDLLALLKHLDAGPALVYGCSNGAAAAVWVAAEAPELVKGLVLAAPFVRD
                     GEAGFAQKLTVALMRVPGLALPLYLSYYPKWEPKPPADFAEHKAKLKAN"
     gene            complement(9283..10281)
                     /locus_tag="IEZ14_RS34245"
                     /old_locus_tag="GCM10010177_69170"
     CDS             complement(9283..10281)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852234.1"
                     /locus_tag="IEZ14_RS34245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69170"
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_229810601.1"
                     /transl_table=11
                     /translation="MRRASGAMFGLAYGDALGAPTEFLTMEQIHRRFGEHGPTQLDGDP
                     ALVTDDTQMAIAVGLGLLDALANPPFTPDLITPMWRRRFVDWLNSPDNDRAPGNTCLRA
                     CRNLAAGESWVEATVAGSKGCGANMRVAPVGLAPGLSDETRAGASQLQAALTHGHPTGL
                     AASELTAFAVRWLADGMAPSDLPAALRARCRDQRAVYHERWLGTLWQQPGMDTPETFIA
                     RGWDECLAVLDRLDEAVERGDRTSDPCAATGAGWVAEEALATGLLCFLLFPEEPVGAIR
                     RGAASSGDSDSIACLAGAFAGAHLGMDAWPGEWSARIEYAADLARLGGAWD"
     gene            complement(10297..11103)
                     /locus_tag="IEZ14_RS34250"
                     /old_locus_tag="GCM10010177_69180"
     CDS             complement(10297..11103)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544104.1"
                     /locus_tag="IEZ14_RS34250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69180"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_229810602.1"
                     /transl_table=11
                     /translation="MDWSRYWRSPDRPLEAMHAHFERHAYHRHSHETYSFGVTEDGFQA
                     FRCRGGAHTSAAGMVIAFNPDDPHDGHAADELGFTYRIVHIGAGLISDVLADIAARPVG
                     LPLFDSPVVPDPALAGALRGLHAALLGGAPALRRDELLTAAVGTLVDRAATRRLRATPA
                     GGFVERARRRLEESYTDDIGADALAEAAGCSRFALYRGFRREYGMAPSDYQRQLRLRAA
                     RRLLACGDAIGDVAARTGFADQSHLTRWFVRCYGVTPGGYRDACTG"
     gene            11167..11577
                     /locus_tag="IEZ14_RS34255"
                     /old_locus_tag="GCM10010177_69190"
     CDS             11167..11577
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544101.1"
                     /locus_tag="IEZ14_RS34255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69190"
                     /product="DUF2000 domain-containing protein"
                     /protein_id="WP_179836021.1"
                     /transl_table=11
                     /translation="MRFDTKIGIVVRDDLAAWQRLNVTAFLAGAVAGGVPGILGEPYED
                     ASGNTYLAMFRQPVLVYEAGTEAISTAHARALAREMDTAVYIEDMFKTGHDEANRATVR
                     AVAAEEMPLVGFAVHGPKNGVDKVLKGLRLHP"
     gene            complement(11552..12649)
                     /locus_tag="IEZ14_RS34260"
                     /old_locus_tag="GCM10010177_69200"
     CDS             complement(11552..12649)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852235.1"
                     /locus_tag="IEZ14_RS34260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69200"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_179836020.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.9e-16, bitscore:
                     54.1, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.6e-31, bitscore:
                     102.8, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLVVTEEQRELRDALRRFFADRSPGAEVRRLMETAEGYDPKVWR
                     QMAEQLGLQGLAIAEDHGGAGFGVRELAVVFEEMGRAVVCAPFLATITAAAALEAGEGG
                     HDLLPGLADGSVIATLAVAEDDGSWDPGSVRAAFEGGVLRGTKNFVLDGHVADLVLVAA
                     QGEDGVGVYAVEDAAGLVRQALPTLDQTRRLARIELDGVPARRVGGPEALARALDVAAV
                     ALAAEQLGGAQRTLDMTVEYAKVRHQFGRPIGSFQAVKHRCADMFVLVESARSAVLNAA
                     AAADESPDELPAAAALAQAYCSESFFHTAGEAIQLHGGIGFTWEHDAHLYFKRAQSSRE
                     LFGSPDRHRERLAALAGLTGAAATP"
     misc_feature    complement(12634..12648)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.52"
                     /tool="antismash"
     gene            complement(12741..12983)
                     /locus_tag="IEZ14_RS34265"
                     /old_locus_tag="GCM10010177_69210"
     CDS             complement(12741..12983)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657903.1"
                     /locus_tag="IEZ14_RS34265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69210"
                     /product="hypothetical protein"
                     /protein_id="WP_179836019.1"
                     /transl_table=11
                     /translation="MDERDVPRGDVQELSDFELVVYETVAEIDKERGAADFETIGALVD
                     APEEDLWAALGHLVSINHLHSTSKGYVLGPHDWAP"
     gene            13176..13982
                     /locus_tag="IEZ14_RS34270"
                     /old_locus_tag="GCM10010177_69220"
     CDS             13176..13982
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017606605.1"
                     /locus_tag="IEZ14_RS34270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69220"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_179836018.1"
                     /transl_table=11
                     /translation="MPDVPQGRPAEADLQTDRPHSARVYDYIIGGKDNYAADRETAATV
                     LANWPGLRTSMIANRACMQRMGRHLAELGVRQFIDVGTGIPSSPNLHEVVQEVAPDARI
                     VYVDNDPIVLAHARALLTSTPEGRTAYIEADMRSPETLHNDPALRDVLDLSRPVALTVI
                     AMLQFVEDAAGLVEALVAPLAPGSCLAVTIPTGDLAPESRRLADDYTSSGIPMYLRDHA
                     EVERLFAGLELLDPGVVPMPRWRPAPGAPVLPDTATNMYAAVGRKP"
     gene            complement(14074..14712)
                     /locus_tag="IEZ14_RS34275"
                     /old_locus_tag="GCM10010177_69230"
     CDS             complement(14074..14712)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF025605.5"
                     /locus_tag="IEZ14_RS34275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69230"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_179836017.1"
                     /transl_table=11
                     /translation="MSAAGASPTRGRQRRGEELRRHILLVAKDVFLETGYERASMDTVA
                     TRAGTSKRSLYAHFESKDKLFLAVMDWVRELYLGRLKTPDAYAEDPAEAVTLFCGRFLQ
                     LMAWEPQVRTCRLCIAEAERLPGSSSAYFDAIFASTQERLTGYLAEHHVLDAAALAEDL
                     LARTVLPRLFRTLLNVEGPSRDEPGEEALPAAVDLPAIRRLVSAALQGG"
     misc_feature    14783..14798
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            14784..15689
                     /locus_tag="IEZ14_RS34280"
                     /old_locus_tag="GCM10010177_69240"
     CDS             14784..15689
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076649.1"
                     /locus_tag="IEZ14_RS34280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69240"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_179836016.1"
                     /transl_table=11
                     /translation="MIVITAPTGNIGHQVVDHVLAAGEPVRVIARDPARLPADVRERVE
                     VVQGSHGDARVVAQAFDGADAVFWLLPSDPRAADVDESFVGFTRPAAEAMRGLGVERVV
                     DVSALGRGTPQAGRAGHVTASLAMDDLIAGTGVAFRALTAAGFMDNVLRQLRTIKEQGL
                     FFDVIPPDRELRVVATRDIAAVAARLLLDTTWTGQEEIPLLGPENLSYNDIAAVISDVL
                     GTSVQYEQIPAQALTERLTARGMSGAMVQSMLDMLAAKESGLDDAIVRTPRHVIDTPTT
                     FRQWCEEVLKPAVHATGRQP"
     gene            complement(15680..16705)
                     /gene="sbnB"
                     /locus_tag="IEZ14_RS34285"
                     /old_locus_tag="GCM10010177_69250"
     CDS             complement(15680..16705)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019290 - siderophore biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sbnB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657902.1"
                     /locus_tag="IEZ14_RS34285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69250"
                     /product="2,3-diaminopropionate biosynthesis protein SbnB"
                     /protein_id="WP_179836015.1"
                     /transl_table=11
                     /translation="MTQAPTFAVVSGAQVHEAVAGREAEVTRMVEAAYRLHGEGLTVNP
                     DSYFLRFPDRPSDRIIALPASVKGGVGVHGIKWISSFPGNVASGVPRASAVLILNDAET
                     GYPFACLESSIISAARTAASAALAAAALADRRGGRPRRIGFVGVGLIARYIHTYLAGNG
                     FTFDELGVHDLSREHAEGFQGYLERTEKGAITIHDSAESLIRSSDLVVFATVAGEPHVT
                     DPGWFAHNPLVLHVSLRDLSPEIILSSYNVVDDVEHCLKANTSPHLAEQRVGHRDFVAG
                     TLYDVLSGTTAPPADKPVVFSPFGLGVLDLAVAKYVYDRVASSGALNTVPGFFHEMKRY
                     G"
     gene            complement(16734..17699)
                     /gene="sbnA"
                     /locus_tag="IEZ14_RS34290"
                     /old_locus_tag="GCM10010177_69260"
     CDS             complement(16734..17699)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="sbnA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634299.1"
                     /locus_tag="IEZ14_RS34290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69260"
                     /product="2,3-diaminopropionate biosynthesis protein SbnA"
                     /protein_id="WP_179836014.1"
                     /sec_met_domain="PALP (E-value: 1.7e-49, bitscore: 162.0,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIITSPQEFNVDDLYVDLRHVIERPLYLKCEGFNFAGSVKLKAA
                     AAMVEAAERDGALTPDSIIVESSSGNLGIALSLIAASRGLRFVCVTDPRCNPASMRVMR
                     ALGAEVRVVSDRDANGGYLGGRIDYVRNLCASGGGYVWLNQYANRNNWLAHYRGTAPAI
                     DREFPDLEVLFVGAGTTGTLMGCARYFREHRRPVTIVAVDAVGSVTFGGLPERRMVPGL
                     GTSSKPALVDESFIDDVVHVPETDTIRTVHALASRGFLFGGSTGTVVSGASRWLEAKYP
                     GEDPVAVAIAPDLGERYLDSLYEENWLREHFGDPAAILGD"
     misc_feature    complement(17889..17905)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.79"
                     /tool="antismash"
     misc_feature    17889..17905
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.62"
                     /tool="antismash"
     gene            17936..19540
                     /locus_tag="IEZ14_RS34295"
                     /old_locus_tag="GCM10010177_69270"
     CDS             17936..19540
                     /NRPS_PKS="Domain: AMP-binding (58-501). E-value: 2.7e-85.
                     Score: 278.4. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS34295_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657900.1"
                     /locus_tag="IEZ14_RS34295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_69270"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_179836013.1"
                     /sec_met_domain="AMP-binding (E-value: 7.3e-90, bitscore:
                     294.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSARGPAVDRLLPLAGLPALDVPAAQAERARELAARLGMLRERDV
                     DLAGPVIARVERIAAERDRPAVADEHRTLSYAELAAEARRLAALLEDEGVRPGTVVGVG
                     GGRCAGVIAAFLAIELVGALYVPADETWPAARVRDVLGQAGASVLITVDAQDRGAAGER
                     GGRSSRDDAREVAPALLEGAAEAGCRVVGAARADGLAPWAGEPRLSALDQPRYVLFTSG
                     STGRPKGAVVEHQGMLNHLWAKIIDLELTGDDVVAFTAPLGFDISIWQMLCPLLLGGRV
                     DVIGDEVGHDPVAFARAVDGQGITVVELVPTMVRHLLDDLAPGASPARDGGPRPLAGLR
                     WMIATGEELPAELSRRWLETMPHARLLNAYGPTECSDDVTHHTVTAGDLDLLRLPIGTP
                     VVNARLYVLRSEADGATAEGTWSACDVGETGELFVGGVVVGRGYLGDDERTREAFYRDP
                     FGASPTGRLYRTGDAVRLLPPGAGGEDRPTLQYLGRVDRQVKIAGVRMELGEIEAVLQR
                     HPAVRAAAVVVHEYPGR"
     aSDomain        18110..19438
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS34295_AMP-binding.1"
                     /evalue="2.70E-85"
                     /label="IEZ14_RS34295_AMP-binding.1"
                     /locus_tag="IEZ14_RS34295"
                     /protein_end="501"
                     /protein_start="58"
                     /score="278.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AAERDRPAVADEHRTLSYAELAAEARRLAALLEDEGVRPGTVVGV
                     GGGRCAGVIAAFLAIELVGALYVPADETWPAARVRDVLGQAGASVLITVDAQDRGAAGE
                     RGGRSSRDDAREVAPALLEGAAEAGCRVVGAARADGLAPWAGEPRLSALDQPRYVLFTS
                     GSTGRPKGAVVEHQGMLNHLWAKIIDLELTGDDVVAFTAPLGFDISIWQMLCPLLLGGR
                     VDVIGDEVGHDPVAFARAVDGQGITVVELVPTMVRHLLDDLAPGASPARDGGPRPLAGL
                     RWMIATGEELPAELSRRWLETMPHARLLNAYGPTECSDDVTHHTVTAGDLDLLRLPIGT
                     PVVNARLYVLRSEADGATAEGTWSACDVGETGELFVGGVVVGRGYLGDDERTREAFYRD
                     PFGASPTGRLYRTGDAVRLLPPGAGGEDRPTLQYLGRVDRQVKI"
     CDS_motif       18581..18637
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS34295_0001"
                     /evalue="1.50E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="IEZ14_RS34295"
                     /protein_end="234"
                     /protein_start="215"
                     /score="29.8"
                     /tool="antismash"
                     /translation="YVLFTSGSTGRPKGAVVEH"
     CDS_motif       19211..19297
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS34295_0002"
                     /evalue="1.70E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="IEZ14_RS34295"
                     /protein_end="454"
                     /protein_start="425"
                     /score="36.4"
                     /tool="antismash"
                     /translation="VGETGELFVGGVVVGRGYLGDDERTREAF"
     CDS_motif       19406..19471
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS34295_0003"
                     /evalue="5.40E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="IEZ14_RS34295"
                     /protein_end="512"
                     /protein_start="490"
                     /score="31.4"
                     /tool="antismash"
                     /translation="YLGRVDRQVKIAGVRMELGEIE"
     misc_feature    complement(19553..19566)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.78"
                     /tool="antismash"
     misc_feature    19640..19655
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.55"
                     /tool="antismash"
     misc_feature    19708..19725
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.08"
                     /tool="antismash"
     misc_feature    19710..19725
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.83"
                     /tool="antismash"
     gene            20001..>21541
                     /locus_tag="IEZ14_RS34300"
     CDS             20001..>21541
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_Starter (4-298). E-value:
                     5.2e-90. Score: 293.7. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS34300_Condensation_Starter.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IEZ14_RS34300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_189269964.1"
                     /sec_met_domain="Condensation (E-value: 2.6e-37, bitscore:
                     121.7, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.2e-09, bitscore:
                     28.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTEYVPLSAAQQSVWYAQQLAPRTPIHIAQYIEIEGAVDHELFD
                     RVARIAAHEALAMNARLAERDGLAHQVLDPDATATIPLVDLSGEPDPDAAARAWMRQAM
                     AEPLPLDAERLYSTALLRLAPGLHRWFIRAHHVIQDAYSGSIISRRAAEIYTALANGGE
                     YVSAEAGDYRRVLAEEEAYRASEKFERDRAYWTERFADRPVAVSLSEEMAEPTADYLSL
                     ISVVPPDRTAELAVGARRLRTATQGLAIAATAAYVARMTGTEDVVLGLAVTGRTTQIAL
                     DTPAMLATILPLRVHVRPDMTVDELVRAATRASARALRHQHYRREDLLRDLKLLGERRR
                     LHGPVINIMAFDYRLDFAGLPARMHAITTGPIDDLSINIYDNFDGAGMRVDFEAHPDLY
                     TEGQVATHLDRYIRFLGALADVDPATPLREVELLDDAERSRVLEEWNDTAAPVEPAVVP
                     ELFEAQAARTPDAPAVTRGGTTLTYRELDERANRLARHLIARGVGAEDFVALALPR"
     aSDomain        20013..20894
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS34300_Condensation_Start
                     er.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="5.20E-90"
                     /label="IEZ14_RS34300_Condensation_Starter.1"
                     /locus_tag="IEZ14_RS34300"
                     /protein_end="298"
                     /protein_start="4"
                     /score="293.7"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHVIQDA"
                     /tool="antismash"
                     /translation="YVPLSAAQQSVWYAQQLAPRTPIHIAQYIEIEGAVDHELFDRVAR
                     IAAHEALAMNARLAERDGLAHQVLDPDATATIPLVDLSGEPDPDAAARAWMRQAMAEPL
                     PLDAERLYSTALLRLAPGLHRWFIRAHHVIQDAYSGSIISRRAAEIYTALANGGEYVSA
                     EAGDYRRVLAEEEAYRASEKFERDRAYWTERFADRPVAVSLSEEMAEPTADYLSLISVV
                     PPDRTAELAVGARRLRTATQGLAIAATAAYVARMTGTEDVVLGLAVTGRTTQIALDTPA
                     MLATILPLRVHVR"
     CDS_motif       20019..20057
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS34300_0001"
                     /evalue="5.80E-04"
                     /label="C1_starter_004-017"
                     /locus_tag="IEZ14_RS34300"
                     /protein_end="19"
                     /protein_start="6"
                     /score="12.5"
                     /tool="antismash"
                     /translation="PLSAAQQSVWYAQ"
     CDS_motif       20076..20186
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS34300_0002"
                     /evalue="5.80E-09"
                     /label="C2_starter_024-063"
                     /locus_tag="IEZ14_RS34300"
                     /protein_end="62"
                     /protein_start="25"
                     /score="28.6"
                     /tool="antismash"
                     /translation="PIHIAQYIEIEGAVDHELFDRVARIAAHEALAMNARL"
     CDS_motif       20400..20465
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS34300_0003"
                     /evalue="1.20E-06"
                     /label="C3_starter_134-155"
                     /locus_tag="IEZ14_RS34300"
                     /protein_end="155"
                     /protein_start="133"
                     /score="21.4"
                     /tool="antismash"
                     /translation="AHHVIQDAYSGSIISRRAAEIY"
     CDS_motif       20793..20882
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS34300_0004"
                     /evalue="4.50E-10"
                     /label="C5_starter_265-294"
                     /locus_tag="IEZ14_RS34300"
                     /protein_end="294"
                     /protein_start="264"
                     /score="31.9"
                     /tool="antismash"
                     /translation="DVVLGLAVTGRTTQIALDTPAMLATILPLR"
     CDS_motif       20943..21044
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS34300_0005"
                     /evalue="1.00E-15"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="IEZ14_RS34300"
                     /protein_end="348"
                     /protein_start="314"
                     /score="50.1"
                     /tool="antismash"
                     /translation="ARALRHQHYRREDLLRDLKLLGERRRLHGPVINI"
ORIGIN
        1 tcgaggtgca ccgccggcac cgggcgcggc ggcaggcgcc gctggcgggc cgcggcgtcc
       61 gggaggtccc ggacgaggcg cagcgcgtcg gcgagcaggc ggtgggcgcg gtccgggtcg
      121 ggctcgccgg acgcggcctc gcgcaggcgc agcgcggtgc cgaggcggtg ccgggcctcg
      181 gcggcgagca cctcctcctc gggcggctcg gcgccggggg aggggtgcgg gacccgcgcg
      241 gcgtcggcca gcccggtcgc cgcgtgcacg tcgccggcgt ccagcagcgc ccggagccgt
      301 cccgcgaggc cgccgcccgg gtcggtctcg cgcacgacgg cgaacaccag gcggcgggcg
      361 tcgccctgct cgacgcccag ctcctcggcg gcgtaccgga gcagggcgcg ctcggacgcc
      421 cgctgccgca ggcgctcgcg gagccggtcg gcgatgtcga acagcagcag cccgggcagg
      481 tcggcgcccg agcgcagcgc cgccagcacg gtgtcggcgt gggtggtggt ggtgtcgcgg
      541 ctgcggcggg cccactcggc tccggcggcc gcgaccgcgt ccgcgtccgg gcgcggctcg
      601 ccgcccgcaa cggcgaagcc gtccaggacg cggatcgggc cggtgaggcg ggcgccgaac
      661 aggaagtcgg tgaggtgccg gttgccgagg atctccagcg actcgcgcac cttccggtac
      721 gcgggatagg gcgcggcgga cggcagcggg tcgggctcgc ggatctcgac gccgtcggcg
      781 gcggcgagat ccgtcagctc ggcgccccgc accccggtgg tgcgggcgat ggcctcgacc
      841 tccgcgggcg tggccatccg cagcgtcccg gccgcgtcgg cgaggcgggc gcgggcctcg
      901 ccgaggcggc gctcggcgcg ctcgcggccg ccgcgcagcc gcgcctccag cgggcgcggg
      961 tcgccgcgct cggcggcgga gaacagcggc gccagctcgc ggtgctcggc ctccagccgg
     1021 tcgatgagct tgcggtactt cagctgcccg cgcgcccgcc gccagcactg ccggacctgc
     1081 ctgacccgcg ccgcgacggc cgccccagtg agtccgtcga atggcggtgg gtgggagttg
     1141 gaggacggtg ggccctccag cgcgtaccgg acgcgcaggt cctcgggggg ccggtcgccc
     1201 gcggcccgcg cgggttccag cacctcccgc aggtagtcct cgtcgaacgc cacgggcgcc
     1261 tccaggggat ccgcggcccg ttcagctgac ctggacccgg gagagggcct tgcgggagcg
     1321 ctcgacctcc tcctccgaca tgccgccgac gtccaccttc agctccagcc gctcgccggt
     1381 ctccttctcc atggccgtga cgttcagcag gccggaggag tcgagcgcga acgtcacccc
     1441 gatcggccag cccgccttct tgcccggcgg gacgcggatc tccccggtcg cgatctcggt
     1501 gttgtcgatc aggtcggcgg actccaccac gccggcctgc tccatcaccc ggatgtcggc
     1561 cgaggcctgg tcgtcgtaga cggtgaagaa gtcctcggtc ttggcggcgg gcagctcgtc
     1621 gttggcgtgc acgaggtgcg cgacgctctc ggcgccggtg tcccggtcga cgaccacgat
     1681 cccgaacgcg tgcgaggcga ccgtcctgat ctgccgcccg gcgatctgcc gctgctgctc
     1741 ggccgacagg cccgcccggt tcgccatctc ctcggcgcgc tcggcggcgc cctcccggac
     1801 gagccgccgg taggtctcct cgaacgcgta cagggcggcg cccttggcga ccgcgaggtc
     1861 ggggtcctgg aggcgggggg cgaggccgag ctcggtctgc agccgcgccg cgacgaccgg
     1921 catcttcgtg gagccgccga cgaggacgag gtcgtcgtag tcctccacgc ccttctcggc
     1981 ggcggtcgcc agcgtccggc cggtgatctc cacggtgcgg tcgaggaggt ccttggtcag
     2041 ctcctccagc ttctcccgcg tcacctcgac cgaggcgacc cgcccgccgt gcatcacccg
     2101 gacggtgtgg gacgtgcggg tggtgagggc cttcttggcg tcctcggcgt cgcggcgcag
     2161 ctgctgctcg gtctgccggt cgtccagcgg gtcgccggcg cccgggtgct cggcgcggaa
     2221 ccgctcggcc aggtgctcca cgagccgggc gtcccagtcg gcgccgccga gctcgtggtc
     2281 gccgtcggtg cacaccacct cgatgtggcc ctcgcgcagc gcgatgaccg tggtgtcgaa
     2341 cgtcccgccg ccgaggtcgt acaccaggat cgtgcggtcg ctctcggggt tgaggacgcc
     2401 gtaggtgatc gcggcggcga tcggctcgga cacgatgtcg atgacgttca gccccgcgat
     2461 gcggcccgcc ttgcgggtcg cgtcgcgctc ggccacgccg aagtaggccg ggacggtgat
     2521 gaccacgtcg cgggcctcct cgcccgtcgt ggtgcgcgcg tcagtggcca gcttcagcag
     2581 gatgaacgcc gacacctcct cgggagtgaa gtcgatcccg tggacggggc gcgtgacgtc
     2641 ccggcccatg tcccgcttga tcaggctgac gaccttgtcg ggctccagga ccgcggtgtc
     2701 cttcgcggtc tggccgacga cgacgttctc gccgctctcg aagaacacga ccgacggggt
     2761 ggtgtcggtg ccctccaggt tccgctggac ggcgggccgg cccacatcgt cgatggaggc
     2821 aatgcaggag tacgtcgttc ccaggtcgat cccgtagacg gccatgtccc tcacccgctg
     2881 ttcgtcgtct gtccgttgtg cgccgcctcg ccggcgggcg ccggctcggc gagcctgccg
     2941 acgctgaccg ccgccttgcg cagcaccttc ccgctctgct cgaacccgtc ggactgcacg
     3001 gtcgtgacgg tgccgtccgc cacggggtcg tcgaccggcg tgaccgcgac cggacggtgc
     3061 cgggacgcgt cgtagggggc gcccggctcg acggtgaacc gctcgacgcc gagccgcgcg
     3121 agcgcgtcgg cgacgtcgtc ggccaccgcg gccagcagca ccgccgtccg ccgcgggtcg
     3181 ggcgcctcgg tgagatcggg tgcgcggagc cggtcggact cgcggcgcgc ctggtcgtgc
     3241 agccggtaaa gcgccgcgcg gacgggctcc agcatcgcct gcagctcccc gcgccgcagc
     3301 cgctggttct cctcgtgcag ccggtcgatg accgcctcgc ggtgctccgc gcgctcccgc
     3361 tcgcggtcga ggcgggcggt gagcccggcg agggcgtccc gcacctcggc gtgcagcacc
     3421 gcgccggcgt ctcccgcccc ggcgttcccg gcgttcccgg cgcgccccgg ctcgggcccg
     3481 gcaccggagg cttcgctgac tgggggttcc ccgtccctcg acacgtagag tcaccttaat
     3541 gctgggcggc aggagacgtc aggccaaccg atgacctcca ccggactcta gtttgacccg
     3601 tgcccgccgt tccagcaccg agtttgcgtg ccgcttttct tgggacgaca cgtctgggta
     3661 acacggggga aacgggtgtc gccgaagctg gggacctcgc acggagactg gaggtggcga
     3721 tgttgctgcg gataagggtg cggctgccgg accgtcccgg ttcgctggga caggtcgcgc
     3781 gcaccctggg cgcggcgggc gcggacgtcg tccagatggc ggtgctggag cgcgacaacg
     3841 gccgggcgat ggacgacttc accgtcgcgt ggcccgcggg ggccgactcc gagcggctgg
     3901 ccggggggct cggaacggtg ccgggggtgg aggtcgtcgg gatctggccg accgccgagc
     3961 cgcagggcgc cttccccgac gcggccgtga tcggccaggt cgccgccgtc ccggagcgcg
     4021 gcctggagat cctcgccgac gcggtcccgg ccatcctgag cgccgactgg gcgggcctcg
     4081 ccgagctgaa gggggaggac gaggcggtcc tggtgcacgc cagcgccggc ggcgagccgg
     4141 gcgccgtcct gccggagctg cggccgctgc ggccgcgcgc gttcacggcg caggacggca
     4201 cgcggttcgc ggtctgcccg ctcgccgcgg gcggggtcgc gctggtggtc gcccggacgg
     4261 gcgcgccgcc gttccaccgg acggaggtgt tccggctgga gcagctcgcc ggcgccgcga
     4321 acgccgtcct gcaccgtgtc cgcggcgcgg ccccgctctg agcgcccgtg ccgcttcggc
     4381 tccgggtcag tccagcaggg cgaggaccgc gtccaggtcg gtgaggccgg cgtcggagcc
     4441 gagcccttgg gcgacggtgg ccgccgccgc ggtgccccag cgcgcggcct ccagcacgtc
     4501 cttgccgtgc gtgaggccgg tgatgaaccc cgcgcagtac gcgtcgccgc agccggtcgt
     4561 gtcgaccacc tcgacgggca gcgccggcag ccggtgcgcg ccctcggcgg tggcgacgag
     4621 gctgccgtcc ccgccgagcg tgacgacgac cgtgcccggc ccccgcgcga gcagcgcggc
     4681 ggcggccttc tccgggtcgt cctcgccggt catgagggcg gcctgctcgc cgttcggcag
     4741 gaagtggtcg acgtggggga ggaacgcggc ggcgccgtcc agcaggtcgg gcatgttgga
     4801 cagcaggtcc atcgtcacga cggtgccggc ctcgcgggcg gcggcgagca cggcgaagaa
     4861 ggccgggtcg ttgaggccga aggtgacgtc ggggccgccg aggtgcacgg cgctcgccgc
     4921 ggccagcagg cccggcccga ccgcgtccgc ggtgagggtc aggttcgcgc cggggacgtg
     4981 gaagctcggc cgcccgccgt ccggccggat cggcaggatc gacgcgctgg tctggtcggc
     5041 cgaccgccgg acgagcccgc gcacgtccac gccctcgcgc gtcatgatcg tgaccagcag
     5101 gtcgccgagg tcgtcgtcgc cgatcgcgcc gaccgagacg acctcgttgc cgaggcgggc
     5161 cagggcgacg gcggtcccgg cggcggcgcc cgccgcggtc acccggatct gctcgacgac
     5221 gacggtgtcc tggccgtccg ggatgccctc gaccgggcgg gcgagcacgt ccaggatgtg
     5281 cgcgccgaga gtgacgacgg tcatgacggg ccccttcgtg atcgccaggg ccgtagcgta
     5341 cgccgtgcag gccacaaaat gtgagaggta ttcgcatgtt gctgagggac gagcgggacg
     5401 cgttgtgcgg gatcgggcgg cggctggcgg ggaccgggct cgtgacgggc gcgtccggca
     5461 acatcagcgt ccggtcgggc gacctggtcg cggtcacgcc gggcgggatg atgctcgacc
     5521 ggatggagcc ggccgactgc ccggtcgtga acatcgcggg acactgggtc gacggggaca
     5581 aggcgccgtc gtccgagacg cccatgcacc tcgccctcta cgagacgacc ccggccgccg
     5641 ccatcgtgca cacgcactcc acctacggcg ccgtggtggc gacgaccatg tccgagctgc
     5701 cgccgatcca ctacaacacg ctgctgctcg gcggcgtggt gaaggtcgcc gagtacgcca
     5761 cctacgggac gcccgaactg gcggagaacg tccgggcggc catggcgggc ggcaagcgcg
     5821 ccgcgctgat ggccaaccac gggggcgtca cgatcggccg cgacctggag gaggcgtacg
     5881 agaacgcgcg tctgctggag tggctctgcg gcgtgtacgt ccgcgccagg acgatcgggg
     5941 agccgcgcgt cctgacggag gaggagctgg cgaaggtggt cgagcggggg ctcgcgccgc
     6001 ccgacttccc ccgcgtgtaa cctaacgctt gttaggtcac tctgggaggc ccgccttgcc
     6061 cttcgtcctg gtcgacaggc cgcgcccgaa cgtcgccctc atcaccctca accggcccga
     6121 gcgcatgaac gcgatggcgt tcgacgtgat ggtccccttc cgggaggccc tggaggaggt
     6181 cagccgcgac aacggcaccc gcgtcgtcgt catcaccggc gccgggcggg gattctgctc
     6241 cggggccgac ctggagaacc cggggaacat cccgggcatc gacgggctga cgctcccgac
     6301 gatcgcgctg cgctcgatgg agctgctgga cgacgtggtg cgggcgatgc ggcgcgtcca
     6361 ccagccggtc atcgcggcgg tcaacggccc ggcgatcggc ggcggcctgt gcctgtcgct
     6421 cgccgccgac atccggctgg gcgcggagac ggccctgttc cgcgcggccg ggatcaacaa
     6481 cgggctgacc gcgagcgagc tcggcctcag ctacctgctg ccgcgcgcga tcggcgcgtc
     6541 ccgcgcgttc gagctgatgc tgtccggacg cgacgtggag gccgccgagg ccgagcggat
     6601 cggcctgctg tcccgcgtcg tccccggcga caagctcctc gacgcctgct acgagctggc
     6661 cgagcggatc gccgggttca gccgccccgg caccgagctg acgaagcgga tgctgtggtc
     6721 gagcctggac gccgcgagcc tggacgccca catggggcag gagggcctcg cccagctgta
     6781 cgtccgcctc accacccaca acttcgaaga ggcgatcagg gcgcggaggg agcaccggcc
     6841 gccggacttc caggactgac gcacaccggc cgggtccgcc gctggtacga ccacgccgcg
     6901 gcgcccagcg ccacgccgta ggcggcgaac gcgccgatcc cgcacgccgc caccgtccag
     6961 ccgggccatc cgctgatgag cccgtcgtga gggaggccgc ccagcccgag gacgggcggt
     7021 agcaggtacg cgacggaccc gacgaccccg taggggccga gcgtcagggc gccgagccag
     7081 gccggcgtga gcggcagcca gcgcggcacc ctgcgcccgg ccagcggcgg cgcccaccgg
     7141 gggaagacct gcccccatgt gtgtgtgagc cccatcagca ggaagacgcc ggcgagcgcc
     7201 gagagggtgg tgaagtccag cccgtacctc tccagcgtga ggacgagccc ggacgcgccg
     7261 ttgcgctcga actcggcgac gacctgctcg ccctcgatcc ccgcgaagga acccccgaac
     7321 gcccacgtcg tcttcatggc gacgtagggc gcgaacccga gcgccccgcc ataggcggcc
     7381 caccgaaccg cacgcggtgc gggggacacc ggcgccgggg ccttgaccgt ccccgcctcg
     7441 gcgtgcgccc ggccgcaccg cgcgcacgtc cccgccgtgc cgcgctggta ggcaagggcc
     7501 gtccccgcga gcagggccgc gcccaccgcg cacagggcct cgacgccgaa cctcggccag
     7561 tcgtcgaccg ttccgtcgaa gacgagctgc agcgcgttca tcacgaatcc gaaggttccg
     7621 gcccccgcca gcgcgcacgc ggtccagagc ccggtgagcg gccaccaccg cggcatctgc
     7681 cgccccacgc cgcgcacact cgacaccgcc atgatcccgc cgacgccgag gcaggcggcg
     7741 atcacccacg ccgccgcccg cgctccggcc agcggtgacc cggcgtcccc gccgcccgcc
     7801 cagtagagga ccaccccgac cgcgcccaac gtccacgccc cggccgcgta tcccgcccag
     7861 cgcggccaca gcctcccgac cgattccatg ggacgagcct ctccgcgcgg cagccgccgg
     7921 gcctcccgcc gcggagcgat cgccctaccc cgcgcggggg agcggcgtgg caggctgagg
     7981 gggtgcccaa gcttgcgccg gacgaggcgc gccgcctgct gaccaccgtc ccggtcgcgc
     8041 gcctcgcgac cgtgggggag gacgcccgcc cgcatctcgt ccccgtgacg ttcgccgtcc
     8101 accggggcgc cgtctacacg gccgtcgacc acaagcccaa gagcagccgg gatctgcggc
     8161 gcctcgccaa catccgggcg aatccccgcg tcgcgctcct ggccgaccac tacgaggacg
     8221 actgggaccg gctctggtgg gtccgcgtgg acggccacgc gaccgtcgtc gacgaccccg
     8281 cacgcatggc cgaccccgtc cgcctcctgg cggaccgcta cccccagtac cgcgaacacc
     8341 cgcccgaggg cccggtcatc gccatgacga tcgaggcctg gaccggctgg tccgcgtcct
     8401 agagggagcg ctggaaggtc gtgacggcct cggcgacctt ctcggggaac tccacgtggg
     8461 ggtggtggcc ggcgccgtcc agcaggacga cctggccgtc cagcctctgg ccgacccatg
     8521 cggcctcggc ggccgggtcg ggccagtcga tgtcgcccgt gcccatgatg acgagcgtgg
     8581 gcgcctgcac ccggtcgagc cgcgcctcgg actcggcgtg ggacatgctc aggtactcgg
     8641 cgatgacctt gtcgcggccc ggctccttga agttcgcctt cagcttcgcc ttgtgctcgg
     8701 cgaagtcggc cgggggcttc ggctcccact tggggtagta ggacaggtag agcggcaggg
     8761 ccaggccggg gacccgcatg agggcgacgg tcagcttctg cgcgaacccg gcctcgccgt
     8821 cccggacgaa cggcgccgcc agcacgagtc ccttgaccag ctcgggcgcc tcggccgcga
     8881 cccacaccgc cgcggcggcg ccgttggagc acccgtagac cagcgccggc cccgcgtcca
     8941 ggtgcttgag aagggccagc aggtcgtggg ccagcggcgt gctcccgtac tcgggccacc
     9001 gcgcgctggt ctcgcccatc ccgcgctggt cgacggtcac gacgcggtac ccggcgtcca
     9061 ggagcagcgg ccggaggaac cggtactgcg accgcaggtc gagcatcgag ggcaggcaca
     9121 cgatgagcgg gccgtcgccg ctgtcgtcgt aggccagccg tccgccggga aggtcgagga
     9181 accgggtctc gctcatcgcg cgctccttaa aactctgtag ccctatagct aagaagatta
     9241 gcttttgggc ggagggaagt caagagcggt gctctcgccg ggtcagtccc aggccccgcc
     9301 gagcctcgcg aggtcggcgg cgtactcgat gcgggcggac cactcgcccg gccaggcgtc
     9361 catgccgagg tgagcgccgg cgaacgcgcc ggccaggcac gcgatcgagt cggagtcgcc
     9421 cgagctggcg gcgccgcgcc ggatcgcccc gaccggctcc tccgggaaga gcaggaagca
     9481 cagcaggccg gtggcgaggg cctcctcggc gacccagccc gcgcccgtgg ccgcgcaggg
     9541 gtcggacgtc cggtctccgc gctcgacggc ctcgtccagt cggtcgagga cggccaggca
     9601 ctcgtcccag ccccgggcga tgaacgtctc gggggtgtcc atgccgggct gctgccacag
     9661 ggtgccgagc cagcgctcgt ggtagacggc gcgctggtcg cggcagcggg cccggagcgc
     9721 ggcgggcagg tcggacgggg ccatgccgtc ggccagccac cggacggcga acgccgtcag
     9781 ctcgctcgcc gcgagcccgg tcggatgccc gtgcgtgaga gcggcctgga gctgcgacgc
     9841 cccggcgcgc gtctcgtccg acaagcccgg ggccaggccg accggcgcga cgcgcatgtt
     9901 cgcgccgcag cccttggagc ccgccacggt ggcctccacc caggattccc cggcggccag
     9961 gttccggcac gcgcgcaggc aggtgttccc cggcgcgcgg tcgttgtcgg ggctgttgag
    10021 ccagtcgacg aagcgccgcc gccacatggg cgtgatcaga tcgggggtga acggaggatt
    10081 cgccagggcg tccagcagtc cgagcccgac cgcgatcgcc atctgggtgt cgtcggtgac
    10141 gagcgcaggg tcgccgtcga gctgcgtggg gccgtgctca ccgaaccgcc ggtggatctg
    10201 ctccatggtg aggaactcgg tgggcgcgcc cagcgcgtcc ccgtacgcca gcccgaacat
    10261 cgccccgctc gcccgtctca tgggcggcat tcttccctaa cccgtgcaag cgtcgcggta
    10321 accaccaggg gtcacgccgt agcagcgcac gaaccagcgc gtcagatggc tctggtcggc
    10381 gaaaccggtg cgggccgcca cgtccccgat cgcgtcgcca caggcgagca ggcggcgcgc
    10441 cgcgcggagg cggagctggc gctggtagtc gctcggcgcc atcccgtact cccgccggaa
    10501 cccccggtac agcgcgaacc ggctgcaccc cgccgcctcc gccagcgcgt cggcgccgat
    10561 gtcgtcggtg taggactcct caaggcgccg ccgggcccgc tcgacgaagc cgccggcggg
    10621 cgtcgcgcgc agccgccgcg tggcggcccg gtcgaccagc gtcccgacgg ccgcggtcag
    10681 cagctcgtcg cggcgcaggg ccggggcgcc gccgagcagc gccgcgtgca gcccgcgcag
    10741 ggccccggcc agggcggggt ccggcacgac gggcgagtcg aacagcggca gcccgaccgg
    10801 gcgcgccgcg atgtcggcga gcacgtccga gatcagcccg gcgccgatgt ggacgatgcg
    10861 gtaggtgaag ccgagctcgt cggcggcgtg gccgtcgtgc gggtcgtcgg ggttgaacgc
    10921 gatgaccatc ccggccgcgc tcgtgtgggc cccgccccgg caccggaacg cctggaagcc
    10981 gtcctcggtg acgccgaacg agtacgtctc gtggctgtgc cggtggtagg cgtgccgctc
    11041 gaagtgggcg tgcatcgcct ccaggggacg gtcgggcgac cgccagtacc tgctccagtc
    11101 cacgcctccc agtctggcgc acgagcgttc aagacgtcgg ggccgggccg gggcaggctg
    11161 gaccgcatgc gtttcgacac caagatcggg atcgtggtcc gcgacgacct ggccgcctgg
    11221 cagcgcctca acgtcaccgc gttcctcgcc ggcgccgtcg cgggcggcgt tcccggcatc
    11281 ctcggcgagc cctacgagga cgcgtccggc aacacctacc tggcgatgtt ccggcagccc
    11341 gtcctggtct acgaggcggg gaccgaggcg atctcaacgg cccacgcgcg cgccctcgcc
    11401 cgggagatgg acaccgccgt ctacatcgag gacatgttca agacgggcca cgacgaggcg
    11461 aaccgcgcga ccgtccgggc cgtcgccgcc gaggagatgc ccctggtcgg gttcgccgtc
    11521 cacggcccga agaacggcgt ggacaaggtc ctcaaggggt tgcggctgca cccgtgagcc
    11581 cggcgagggc ggccaggcgc tcgcggtgcc ggtccggcga accgaacagc tcccgggacg
    11641 actgcgcccg cttgaagtac aggtgcgcgt cgtgctccca ggtgaacccg atgccgccgt
    11701 gcagctggat cgcctcgccc gccgtgtgga agaaggactc cgagcagtac gcctgggcca
    11761 acgcggcggc ggcgggcagc tcgtccgggc tctcgtccgc ggcggccgcc gcgttcagca
    11821 cggccgaccg cgccgactcc accagcacga acatgtcggc gcaccggtgc ttgaccgcct
    11881 ggaacgaccc gatcggccgc ccgaactggt gccgcacctt cgcgtactcg accgtcatgt
    11941 ccagggtccg ctgcgccccg ccgagctgct cggccgccag cgccacggcc gcgacgtcca
    12001 gggcccgcgc cagcgcctcc gggccgccga ccctgcgcgc cggaaccccg tccagctcga
    12061 tccgcgccag cctccgcgtc tggtcgagcg tcgggagggc ctgccggacg aggcccgccg
    12121 cgtcctcgac ggcgtagacc ccgaccccgt cctcgccttg ggcggccacg aggaccaggt
    12181 cggcgacgtg cccgtccagg acgaagttct tcgtcccccg cagcacgccg ccctcgaacg
    12241 ctgcccgcac cgaaccgggg tcccaggacc cgtcgtcctc ggccaccgcg agcgtcgcga
    12301 tcactgaccc gtccgcgagg ccgggcagca ggtcgtgccc gccctccccg gcctccagcg
    12361 ccgccgcggc cgtgatcgtc gcgaggaagg gggcgcacac gacggcccgc cccatctcct
    12421 cgaacaccac ggccagctcc cgcaccccga acccggcgcc gccgtggtcc tcggcgatcg
    12481 cgaggccctg cagcccgagc tgctcggcca tctggcgcca caccttgggg tcgtagccct
    12541 cggccgtctc catgagccgc cgcacctcag cgccggggga ccggtcggcg aagaagcgcc
    12601 gcagcgcgtc ccgcagctcc cgctgttcct cggtgacgac gagcttcatc gggcgtcctc
    12661 ccacacgtgt cccaggccta ccggatcatc gtgccgcgcg cccgccgccg cctccgggcc
    12721 tttcccatcc accgggaccg tcagggcgcc cagtcgtgcg ggccgaggac gtaccccttg
    12781 ctcgtcgagt gcagatggtt gatcgacacg aggtggccga gcgcggccca cagatcctcc
    12841 tcgggcgcgt ccacgagagc cccgatcgtc tcgaagtccg ccgcgccgcg ctccttgtcg
    12901 atctccgcca ccgtctcgta cacgaccaac tcgaagtccg acagctcctg cacgtcccca
    12961 cgcggaacat ctcgctcatc catagacaga ccgtgcccac tcacggtcgt tctcagtccc
    13021 gcacgaggcc cggcgcccta cgccggaacc ggcgagccgt ccgcaccgga ggcgatggcg
    13081 gtccggtcgg gtggggcgga aaccggggcc gttcgtgcga tccggaatta gagtgatcac
    13141 ggatctggag gcacgagcga aggcgggtac cggatatgcc ggacgttcca cagggccggc
    13201 ccgccgaagc ggacctgcag accgacaggc cgcactcggc gagggtctac gactacatca
    13261 tcggcggcaa ggacaactac gccgccgacc gggagaccgc ggccacggtg ctggcgaact
    13321 ggccggggct gcgcacctcg atgatcgcca accgggcctg catgcagcgg atgggtcgcc
    13381 acctcgccga gctgggcgtg cggcagttca tcgacgtcgg gaccggcatc ccctcctcgc
    13441 cgaacctgca cgaggtggtc caggaggtgg cgccggacgc gcggatcgtc tatgtcgaca
    13501 atgacccgat cgtcctggcc cacgcgcgtg cgctgctgac cagcacgccc gagggccgca
    13561 cggcgtacat cgaggccgac atgcggtccc ctgaaacgct ccacaacgat ccggcgctgc
    13621 gcgacgtcct cgacctctcc cggccggtcg cgctgaccgt gatcgccatg ctccagttcg
    13681 tggaggacgc cgcgggcctg gtggaggcgc tcgtcgcccc cctcgccccc ggcagctgcc
    13741 tcgccgtcac catccccacc ggcgacctcg cccccgagtc gcggcggctc gccgatgact
    13801 acaccagcag cggcatcccc atgtacctgc gggaccacgc cgaagtggag cgcctcttcg
    13861 ccgggctgga gctcctcgac ccgggcgtcg tcccgatgcc gcgctggcgc cccgcacccg
    13921 gtgccccggt cctccccgac accgccacca acatgtacgc cgccgtcggc cgcaagccct
    13981 agccgggctc gcggatcact gggcggtcca gccgccgtcg acggggacga gggcgccgac
    14041 cgcggcgctc gactccagcc gcacggccgg cgcctaacct ccctgcaggg ccgccgacac
    14101 caggcggcgg atcgcgggaa ggtccacggc tgcgggcagg gcctcctcgc cgggctcgtc
    14161 cctgctcggg ccttcgacgt tgaggagcgt gcggaacagg cgggggagca ccgtccgggc
    14221 gagcaggtcc tcggcgaggg ccgcggcgtc caggacgtgg tgctcggcca ggtagccggt
    14281 gaggcgctcc tgggtgctgg cgaagatggc gtcgaagtac gcgctcgaac tgccgggcag
    14341 gcgctcggct tcggcgatgc agagccggca ggtccgcacc tggggttccc acgccatcag
    14401 ctgcaggaag cgcccgcaga acagcgtgac cgcctcagcc gggtcttcgg cgtacgcgtc
    14461 cggggtcttc agcctgccca gatacagctc gcggacccag tccatgacgg cgaggaacag
    14521 cttgtccttg ctctcgaaat gcgcgtacag cgaccgcttg gacgtcccgg cgcgcgtggc
    14581 gacggtgtcc atcgacgccc gttcgtagcc ggtctccagg aacacgtcct tggccaccag
    14641 caggatgtgg cgccgcagct cctcaccgcg tcgctgccgg ccccgcgtgg gggatgcgcc
    14701 tgctgcactc atcggttgcg tcctcgaaaa taaacggtac ggttgagttt acttaatgcc
    14761 gtggcagccg ttggagggaa gccatgatcg tcattaccgc ccccaccggg aacatcgggc
    14821 atcaggtcgt cgaccacgtg ctcgcggccg gcgagccggt ccgcgtcatc gcgcgcgatc
    14881 cggcgaggct gcccgccgac gtgcgggaac gtgtcgaggt cgtccaaggg tcgcacggcg
    14941 acgcccgggt cgtcgcccag gccttcgacg gagccgacgc cgtgttctgg ctgctgccct
    15001 ccgatccccg cgccgccgac gtggacgagt cgttcgtggg cttcaccagg ccggcggcgg
    15061 aggcgatgcg cggcctcggg gtcgagcgcg tcgtggacgt cagtgccctc ggccgcggca
    15121 ccccccaggc gggcagggcc gggcacgtga ccgcgtcgct ggccatggac gacctgatcg
    15181 ccggcaccgg ggtcgccttt cgcgcgctga ccgcggccgg tttcatggac aacgtgctcc
    15241 ggcagctccg gacgatcaag gagcagggcc tgttcttcga cgtgatccct ccggaccgcg
    15301 agctgcgcgt cgtcgccacg cgggacatcg cggccgtcgc cgcccgcctg ctgctcgaca
    15361 ccacgtggac cggccaggaa gagatccccc tgctgggccc cgagaacctg tcctacaacg
    15421 acatcgccgc cgtcatctcc gacgttctcg ggacctcggt ccagtacgag cagatccccg
    15481 cccaggccct cacggagcgg ctcaccgccc gaggcatgtc cggcgccatg gtccagagca
    15541 tgctcgacat gctggcggcc aaggagagcg gcctggacga cgcgatcgtc cgcacacccc
    15601 ggcacgtgat cgacactccg accaccttcc ggcagtggtg cgaggaagtc ctcaagcccg
    15661 cggtgcacgc gaccgggcgt cagccgtagc gcttcatctc gtggaagaag ccggggacgg
    15721 tgttcagcgc gcccgacgac gcgacccggt cgtagacgta cttcgccacg gccaggtcca
    15781 ggacgccgag gccgaacggc gagaagacga ccggcttgtc ggcgggcggg gccgtcgtgc
    15841 ccgacaggac gtcgtacagg gtcccggcga cgaagtcgcg gtggccgacc cgctgctcgg
    15901 ccaggtgcgg ggacgtgttg gccttcaggc agtgctcgac gtcgtccacg acgttgtacg
    15961 acgacaggat gatctcgggg gagaggtcgc gcagcgacac gtgcaggacg agggggttgt
    16021 gcgcgaacca gcccgggtcg gtgacgtgcg gttcgcccgc gacggtcgcg aagacgacca
    16081 ggtcggacga gcggatcagc gactcggccg agtcgtggat cgtgatcgcg cccttctcgg
    16141 tgcgctccag gtagccctgg aagccctcgg cgtgctcgcg tgacaggtcg tggacgccga
    16201 gctcgtcgaa ggtgaagccg ttgcccgcca ggtaggtgtg gatgtagcgg gcgatgaggc
    16261 cgacgcccac gaagccgatc cggcgggggc gcccgccgcg gcggtcggcg agggccgcgg
    16321 cggccagcgc ggcggacgcg gcggtgcggg cggcggagat gatggagctc tccaggcacg
    16381 cgaacgggta gcccgtctcg gcgtcgttga ggatcagcac ggccgacgcg cgcgggacgc
    16441 cgctcgccac gttgcccggg aagctggaga tccacttgat gccgtgcacg ccgacgccgc
    16501 ccttgaccga ggcgggcagg gcgatgatcc ggtcggacgg gcggtcgggg aagcgcagga
    16561 agtaggagtc ggggttgacc gtcaggccct cgccgtgcag ccggtaggcc gcctcgacca
    16621 tccgggtgac ctccgcctcg cgcccggcga ccgcctcgtg gacctgggcg ccggagacca
    16681 cggcgaacgt tggggcctgc gtcatgtgcg gaactccgta ttcctgtaga tgatcagtcg
    16741 ccgaggatag cggccgggtc gccgaagtgt tcgcgcagcc agttctcctc gtagagggaa
    16801 tcgaggtagc gttcgccgag gtcgggggcg atggcgacgg ccacggggtc ctcgccgggg
    16861 tacttggcct ccagccagcg ggaggcgccc gacaccacgg tgccggtgga gccgccgaac
    16921 aggaacccgc gcgaggccag cgcgtgcacg gtccggatcg tgtcggtctc ggggacgtgc
    16981 accacgtcgt cgatgaacga ctcgtccacc agcgccggct tgctgctggt gccgaggccc
    17041 gggaccatcc ggcgctcggg gaggccgccg aaggtcaccg agccgaccgc gtccaccgcc
    17101 acgatcgtga cgggccggcg gtgctcgcgg aagtagcggg cgcagcccat cagcgtcccc
    17161 gtcgtccccg cgccgacgaa caggacctcc aggtcgggga actcgcggtc gatcgccggg
    17221 gcggtcccgc ggtagtgcgc cagccagttg ttgcggttgg cgtactggtt cagccacacg
    17281 tacccgccgc cggacgcgca caggttccgg acgtagtcga tgcgcccgcc gaggtagccg
    17341 ccgttggcgt cccggtcgga caccacgcgc acctccgcgc cgagggcccg catgacccgc
    17401 atcgacgccg ggttgcagcg cgggtcggtg acgcacacga accgcaggcc gcggctcgcg
    17461 gcgatcaggc tgagcgcgat cccgaggttg cccgacgacg actccacgat gatcgagtca
    17521 ggggtgagcg cgccgtcccg ctcggccgcc tcgaccatcg ccgcggccgc cttcagtttc
    17581 accgaaccgg caaagttgaa gccctcgcat ttgaggtata gcgggcgttc gatgacatgc
    17641 cgaagatcga cgtaaaggtc gtcgacattg aattcctgcg gcgaggttat tatcggcacg
    17701 ctgccaccct gaaatgaaga agcaattccc tcgtcttccc ccgaagttcg ccgcgggctt
    17761 cacgccagag ccatggcgag gcatcacggt accttcgggc atcttgctgc cgcaaccccc
    17821 tgattacccg ccggtagggc agaatgcgtg gtgcttctgc cgggccggac ttaggctatg
    17881 gcggccgctt gttttgctgt tacagcggag aagttctaca acacggagag taaagatgag
    17941 tgctcgcgga cccgccgtgg accggctgct ccccctggcc gggctgcccg ccctggacgt
    18001 gcccgcggcg caggcggagc gcgcccgcga gctggccgcg cggctcggga tgctccgcga
    18061 gcgggacgtc gacctcgccg gcccggtcat cgcgcgggtg gagcggatcg ccgccgagcg
    18121 cgaccgcccc gccgtcgccg acgagcaccg gacgctctcc tacgccgaac tggccgccga
    18181 ggcgcgccgg ctcgccgcgc tgctggagga cgagggcgtc cgccccggca cggtcgtcgg
    18241 ggtgggcggc ggccggtgcg cgggcgtcat cgccgcgttc ctcgcgatcg agctggtcgg
    18301 cgccctgtac gtcccggccg acgagacctg gcccgccgcc cgcgtccgcg acgtcctcgg
    18361 ccaggcgggc gcgtccgtgc tgatcaccgt tgacgctcag gaccgcggag cggccgggga
    18421 gcgtggtggg cggtcctccc gcgacgacgc gcgggaggtc gcgccggccc tgctggaggg
    18481 ggcggcggag gcggggtgcc gcgtcgtcgg cgccgcgcgg gcggacggcc tcgccccgtg
    18541 ggcgggggag ccgcgcctga gcgcgctcga ccagccccgc tacgtgctgt tcacctcggg
    18601 gtcgacgggc cgccccaagg gcgcggtcgt cgagcaccag ggcatgctca accacctctg
    18661 ggcgaagatc atcgacctgg agctgaccgg cgacgacgtg gtcgcgttca ccgccccgct
    18721 ggggttcgac atctcgatct ggcagatgct ctgcccgctg ctgctgggcg gccgggtgga
    18781 cgtgatcggc gacgaggtgg gccacgaccc ggtcgcgttc gcccgcgcgg tggacgggca
    18841 gggcatcacg gtcgtcgagc tcgtcccgac catggtcagg cacctgctgg acgacctggc
    18901 gcccggcgcc tcaccggccc gggacggcgg gccccgcccg ctggcgggcc tgcgctggat
    18961 gatcgccacc ggcgaggagc tgccggccga gctgtcccgc cgctggctgg agacgatgcc
    19021 gcacgcccgg ctgctgaacg cctacggccc caccgagtgc tccgacgacg tcacccacca
    19081 caccgtgacg gccggtgacc tggaccttct ccgcctgccg atcgggacgc cggtcgtcaa
    19141 cgcgcgcctg tacgtgctgc ggtcggaggc ggacggcgcc acggccgagg gcacctggtc
    19201 ggcgtgcgac gtcggcgaga ccggggagct gttcgtcggc ggcgtggtgg tcggccgcgg
    19261 ctacctcggc gacgacgagc ggacccgcga ggcgttctac cgggacccct tcggcgcgtc
    19321 cccgaccggg cgcctctacc ggacgggcga cgcggtgcgg ctgctgccgc ccggcgcggg
    19381 cggcgaggac cgtcccaccc tccagtacct ggggcgcgtc gaccgccagg tcaagatcgc
    19441 cggagtgcgg atggaactgg gcgagatcga ggcggtgctg cagcgccacc cggcggtgcg
    19501 ggccgccgcg gtcgtggtgc acgagtaccc gggcaggtag cgggcccgcc gttcaccgag
    19561 cgtgaccgga ctggccggat tcggttgtca acctttgtca cccggcgagc gtccggccgg
    19621 tccggaacgg accgggcggc cgatgatttt gtcactcctg ttagcaatgg ggtggggcaa
    19681 gttctgcttt tgaggggatt gcgaggcatg tgaccggctg gttgactgtg accccgctac
    19741 tcctgagtag atcgtgggac gcgggcggaa gacgggcgag ggcggaaagc ggcggcgctc
    19801 cgtattggcc ggaacacagg gcgttgactc cgggatcgtg cgggcgatgt gcgtcccccg
    19861 gagggaactc ggggtgaaag gggacgggga aacccgatca gttctgtggt cattctcttt
    19921 gaatttctgc ccgtcggcgt ctcgccggac ccgaatccgg gcgtgaagca aaccccctgc
    19981 gaccgggaaa gcaccgcttg atgtccaccg agtacgttcc cctttcggcc gctcagcaga
    20041 gcgtctggta cgcgcagcag ctggcgccgc gaacgccgat ccacatcgcg cagtacatcg
    20101 agatcgaggg cgcggtcgac cacgagctgt tcgaccgggt ggcgcgcatc gcggcccatg
    20161 aggcgctggc gatgaacgcc cggctggccg agcgggacgg gcttgcgcac caggtgctcg
    20221 acccggacgc gaccgccacg atcccgctcg tggacctgtc cggggagccc gacccggacg
    20281 ccgccgcgcg ggcgtggatg cggcaggcga tggcggagcc gctgccgctg gacgccgagc
    20341 gcctgtactc cacggccctc ctgcggctgg cccccggcct gcaccgctgg ttcatccgcg
    20401 cgcaccacgt gatccaggac gcctacagcg gatcgatcat cagccgccgc gccgccgaga
    20461 tctacacggc gctggcgaac ggcggggagt acgtctcggc ggaggcgggc gactaccgcc
    20521 gggtcctcgc cgaggaggag gcgtaccggg cgtcggagaa gttcgagcgg gaccgcgcct
    20581 actggaccga gcggttcgcc gaccggcccg tcgcggtgtc gctgtcggag gagatggccg
    20641 agccgaccgc cgactacctg agtctcatct ccgtcgtccc gccggatcgg accgccgagc
    20701 tggcggtcgg cgcgcgccgg ctccgcaccg cgacgcaggg cctggcgatc gcggcgacgg
    20761 ccgcgtacgt ggcgcggatg acgggcaccg aggacgtcgt cctcggcctc gccgtcaccg
    20821 gccgcacgac gcagatcgcg ctggacacgc cggcgatgct ggcgacgatc ctgccgctgc
    20881 gcgtccatgt ccggccggac atgacggtgg acgagctggt ccgcgcggcg acgcgggcga
    20941 gcgcgcgggc gctgcgccac cagcactatc ggcgcgagga cctgctgcgg gacctgaaac
    21001 tgctcggcga gcgccgccgc ctccacgggc cggtcatcaa catcatggcg ttcgactacc
    21061 ggctggactt cgcgggcctg ccggcgcgga tgcacgcgat caccaccggg ccgatcgacg
    21121 acctgtcgat caacatctac gacaacttcg acggcgccgg catgcgcgtc gacttcgagg
    21181 cgcacccgga cctgtacacc gagggccagg tcgccacgca cctggaccgg tacatccggt
    21241 tcctgggcgc gctcgccgac gtcgacccgg ccacgccgct ccgcgaggtc gagctgctcg
    21301 acgacgcgga gcgttcccgc gtgctcgagg agtggaacga cacggcggcg ccggtcgagc
    21361 ccgccgtcgt ccctgagctt ttcgaggcgc aggccgcccg cacgccggac gccccggccg
    21421 tcacccgcgg cggcacgacc ctcacctacc gggaactgga cgagcgcgcg aaccgcctcg
    21481 cccgccacct gatcgcgcgg ggtgtcggcg cggaggactt cgtcgcgctg gctctgccgc
    21541 g
//
