LOCUS       NZ_BMRD01000013        30421 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence13, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000013
VERSION     NZ_BMRD01000013.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 240782)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 175667
            Orig. end                         :: 206088
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..30421
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="2"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..30421
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..30421
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:20421]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..20421
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            496..1779
                     /locus_tag="IEZ14_RS27815"
                     /old_locus_tag="GCM10010177_56090"
     CDS             496..1779
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013098.5"
                     /locus_tag="IEZ14_RS27815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56090"
                     /product="VOC family protein"
                     /protein_id="WP_179834076.1"
                     /transl_table=11
                     /translation="MTDPLEALRTPVVPVDPDPAFAARLRERLRRALLQPTGETMTTTT
                     VRETQAEVRSLTPYLCVDDGRRALRWYAEAFGAELRGEPMVMEDGRVGHAELVIGDSVL
                     MLADEWPESGLLGPKARGGPSQSLYLNVPDVDIVFSHAVEMGAVAHRPVADYPYGRNGV
                     VMDPFGHRWVIAGPPLPARPRLRHGDVGYASVWVPDVDRAAAFYGSVLGWHTVPGGAEA
                     GRRVEGLPEQHIGLFGGQEHRTVYLAFAVEDVHGTVRQIRDAGGDAQEPTDEPFGVSAM
                     CTDDQGLRFSVYQPAEAVSPVEGRLAEAAGLTAHHGEISYLTIGVPDIARARSFYGEVL
                     HWEFTPGHTPGGWSVRLGGTEVRPMTGMYGGADHPVVVPMYTVDDIEPAVARVREAGGT
                     ATDPARQPYGVTSECTDDQGSRFYLGQH"
     misc_feature    1989..2009
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.69"
                     /tool="antismash"
     misc_feature    2652..2669
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.12"
                     /tool="antismash"
     gene            2687..3592
                     /locus_tag="IEZ14_RS27820"
                     /old_locus_tag="GCM10010177_56110"
     CDS             2687..3592
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892607.1"
                     /locus_tag="IEZ14_RS27820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56110"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_179834075.1"
                     /transl_table=11
                     /translation="MRVGVLLNERGGVEALGKLADDVRRAVDDGFSSAWMSQIFGLDAL
                     TALAVAGSGVSGIELGTAVVPTYPRHPAVLAQQARTTALALRGRFTLGVGLSHQIVIEE
                     MYGYDFGRPLRHMNEYLSVLAPLLEGENASFTGETLRGNVGLSVPNEGRVPLLLAALGP
                     KMLKLAAERADGTVLWMTGPGTVREHIVPTITAAAEAAGRDAPRVVCVLPVCVTGDVER
                     AREQAGETFEVYGVLPSYRAMMDREGVAGPKDLAVVGDEDAVAAKLEELSEAGVTDFVA
                     AEYMPGDRRTREFLKTVTAK"
     gene            complement(3579..3956)
                     /locus_tag="IEZ14_RS27825"
                     /old_locus_tag="GCM10010177_56120"
     CDS             complement(3579..3956)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892725.1"
                     /locus_tag="IEZ14_RS27825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56120"
                     /product="VOC family protein"
                     /protein_id="WP_179834074.1"
                     /transl_table=11
                     /translation="MTITLNHAIVTAADNDEAARFFAAVMGLEYTGPHPHARHFVPIRV
                     NEGLTLDFMTVAYPQGHHLAFDVDAVTFDTVVDRLDAREIPYGDGPAHADNGRVDENHP
                     LGGRGLYFSDASGNLYEVISP"
     gene            complement(3953..4573)
                     /locus_tag="IEZ14_RS27830"
                     /old_locus_tag="GCM10010177_56130"
     CDS             complement(3953..4573)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545241.1"
                     /locus_tag="IEZ14_RS27830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56130"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_229810462.1"
                     /transl_table=11
                     /translation="MEEKVRRRAPGMSPEQRREMIIRTALPLVAEHGMAVTTAQIARAA
                     GIGEATIFRVFADKDELLDACVAEALRTDLVLAEIGAIPLDQPLPARLAEAAAAIDAYL
                     ARMGLVIGALHATGRRERRVPGSGEPGPDRAAAMTRTCEALAELFEPERDRLRLPVEQI
                     ASLFLGFVFSRARPAAAPDAQPLSVEEYLDVFLHGALKEGNTA"
     misc_feature    complement(4724..4737)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     gene            4850..5770
                     /locus_tag="IEZ14_RS27835"
                     /old_locus_tag="GCM10010177_56140"
     CDS             4850..5770
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634226.1"
                     /locus_tag="IEZ14_RS27835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56140"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_229810463.1"
                     /transl_table=11
                     /translation="MRPVRTLGAAMAIGIVTFAATACGGDDGKTGGTPDGNTITVQAAN
                     GAVAVPAKPKRIVSLSPTHTETLFAIGAGPQVVAVDDYSNHPAGAPRTKLSGFKPNAEA
                     IIAYKPDLVVLSDDLDGIVKSLEKVKVPVLLEPAATNLDEAYDEIGDLGQATGHQAEAK
                     KVTDGMRADIQKTVAASSKAKGLTYYHELDNQLHSVTSKTFAGQVYALFGLQNIADKAD
                     KASGGYPQLSREYLLKQDPDLIFLADTKCCGQNAAALTKRPGWSDLDAVGHGGVVELDD
                     DIASRWGPRLTEFVKAIGDAVQKVQ"
     gene            6024..7043
                     /locus_tag="IEZ14_RS27840"
                     /old_locus_tag="GCM10010177_56150"
     CDS             6024..7043
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657839.1"
                     /locus_tag="IEZ14_RS27840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56150"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_179838586.1"
                     /transl_table=11
                     /translation="MRPLPLAVAVGLLLATLLAGVLVGSAGLPVGGVLKALADRIPFVH
                     ADSGFGVIDENVLFQLRVPRALMAALVGGMLAVAGAGYQGVFRNPLADPYLLGAAAGAG
                     VGATLVIALVPGDPGYTVPLAAFVGAIGGVALAYVLGSVATGRGNGTATLVLAGVAVSS
                     FLAAVQTLIQQMKSEELQRIYSWILGGVGSADWHQLALVFPYALVSTVVLLAHGRLLDV
                     LSVGDEEAASLGLSAARVRLTVLVAASLATASAVAVSGLIAFVGIVVPHVVRRLAGGSY
                     RIVLPLSLLGGAAFLEVADLVARTVIRPGEVPLGVVTAFVGGPFFVAVLRASRRQVET"
     gene            7040..7810
                     /locus_tag="IEZ14_RS27845"
                     /old_locus_tag="GCM10010177_56160"
     CDS             7040..7810
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634228.1"
                     /locus_tag="IEZ14_RS27845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56160"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_179834073.1"
                     /transl_table=11
                     /translation="MTVSVRGLDVALGGRRVLKGVSLEVPAGSWTAVIGPNGAGKSTLL
                     RAVLGLVPSHGEISLAGADLQSLKPRQRARLVAYAPQSPSLPVGMTVYDYTLLGRSPYI
                     PHLGRESARDRAITGEVLDRLGLTPFASRPLDHLSGGERQRVVLARALAQQTSVLLLDE
                     PTTALDIGHQQQVMELIDRLRLSDGLTVVTTIHDLTLAGQYADGLVLISGGRVAASGPP
                     GLVLTRDAVEEHFDARVSVTPGPGGRPILSLERP"
     gene            7807..8493
                     /locus_tag="IEZ14_RS27850"
                     /old_locus_tag="GCM10010177_56170"
     CDS             7807..8493
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634229.1"
                     /locus_tag="IEZ14_RS27850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56170"
                     /product="adenosylcobinamide amidohydrolase"
                     /protein_id="WP_229810464.1"
                     /transl_table=11
                     /translation="MNLETVWRVEDGRRLASTVWRAGRGHRMISSAMLGGGIGPARWVL
                     NAQVPGAYARTDPVAHLAELAAAGGLEGPGVGMLTAASVARTVRRDGEGVRVSATVGLR
                     VPTWAASPAGAPDPELAPLDGDATPAWKPGTINIVVAVPVQLSDAALVNAVVTATEAKT
                     QALLEAGFPCTGTASDAICVAAAAGGTPEVFAGPRSTWGARIARTVHAAVRAGALDYAS
                     RLEARG"
     gene            complement(8602..9924)
                     /locus_tag="IEZ14_RS27855"
                     /old_locus_tag="GCM10010177_56180"
     CDS             complement(8602..9924)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853001.1"
                     /locus_tag="IEZ14_RS27855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56180"
                     /product="chromosome segregation ATPase"
                     /protein_id="WP_179834072.1"
                     /transl_table=11
                     /translation="MEDQKVAPFDNVAPTPAAPTQTDLPVITDPAAYAEGDDPARPRGS
                     SGALPDVPPGGAGEPPAPEDDRAGIARLGDPVAVWPCAGCGRPVPQPVRGARTVRYCQD
                     GDGTCERAARESRERGLEAPGLTGQVAWTWEMVDRLEGLADRLAGSLISELSVAGVERR
                     IAEARAEAAGLVAIAQRERDASQRQAEVAWRETATARARAEAAEQEAASARAEAERLAA
                     ERDAARRERQEAEDDADGAGAARIAAERDRDRMASREGELLASLESARAELVTLHGRLS
                     EADTLVEGQRVEAAAATRAAEDLRSAVRDAEAKRGQAVADRDQIQARASELERHNWQLA
                     RAVEELRATVRALTAERDAARAEAERARRRVDALTALSEGRADPGPAGPRPAVDREPPT
                     GLHSLPPMNGSLLDGGDPLATDPLRRNGHGGHNGHRLPHAG"
     gene            complement(10001..11548)
                     /locus_tag="IEZ14_RS27860"
                     /old_locus_tag="GCM10010177_56190"
     CDS             complement(10001..11548)
                     /NRPS_PKS="Domain: AMP-binding (9-412). E-value: 1.3e-85.
                     Score: 279.4. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS27860_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546836.1"
                     /locus_tag="IEZ14_RS27860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56190"
                     /product="AMP-binding protein"
                     /protein_id="WP_179834071.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-92, bitscore:
                     303.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVEGVGFYEIARNDPDRPAVLAPGVPISYGELLAEVNRLSNALA
                     GMGLRPGDTLATVLGNRPEFLTVLLAAVQSGLYLVPVSRHLTAPEIGYILGDSGAKAVI
                     TESALAEAVSGAADEAGVPAEGRVSVDAGDGYGSMAALCATGSAEPPARRRMGSVMLYT
                     SGTTGRPKGVRRPLLDIAPEVLMDIMRRTLGRHLGLEPGDEVHLAVGPLYHSAPCVHAM
                     MALNLGHAVVVAPRFHPEHTLELVQRHGVTNTFMVPTMFHRMLALPDGVRARYDLSTLR
                     QVYHSAAPVPVETKQRMMEWWGPVLYEYYGSTESGPVVVATPHEWLARPGTVGRAVDGV
                     RIRILDPEGAELPPGETGLIYATGQPGFEYHGDPAKTAAAMRDDYYTPGDLGHLDEDGW
                     LYMSDRRTDLIISGGVNVYPAEIESVLLQHPAVADVAVIGVPDDDWGQRVVALVEPAED
                     AEPGEGLAAELLAHCAPRLAKLKHPRRLEFRESLPRTPSGKLSRRRVREAYLGQRAD"
     aSDomain        complement(10313..11521)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS27860_AMP-binding.1"
                     /evalue="1.30E-85"
                     /label="IEZ14_RS27860_AMP-binding.1"
                     /locus_tag="IEZ14_RS27860"
                     /protein_end="412"
                     /protein_start="9"
                     /score="279.4"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="EIARNDPDRPAVLAPGVPISYGELLAEVNRLSNALAGMGLRPGDT
                     LATVLGNRPEFLTVLLAAVQSGLYLVPVSRHLTAPEIGYILGDSGAKAVITESALAEAV
                     SGAADEAGVPAEGRVSVDAGDGYGSMAALCATGSAEPPARRRMGSVMLYTSGTTGRPKG
                     VRRPLLDIAPEVLMDIMRRTLGRHLGLEPGDEVHLAVGPLYHSAPCVHAMMALNLGHAV
                     VVAPRFHPEHTLELVQRHGVTNTFMVPTMFHRMLALPDGVRARYDLSTLRQVYHSAAPV
                     PVETKQRMMEWWGPVLYEYYGSTESGPVVVATPHEWLARPGTVGRAVDGVRIRILDPEG
                     AELPPGETGLIYATGQPGFEYHGDPAKTAAAMRDDYYTPGDLGHLDEDGWLYMSDRRTD
                     LIIS"
     CDS_motif       complement(11030..11071)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEZ14_RS27860_0001"
                     /evalue="4.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="IEZ14_RS27860"
                     /protein_end="173"
                     /protein_start="159"
                     /score="19.4"
                     /tool="antismash"
                     /translation="MLYTSGTTGRPKGV"
     gene            11770..13869
                     /locus_tag="IEZ14_RS27865"
                     /old_locus_tag="GCM10010177_56200"
     CDS             11770..13869
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS27865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_56200"
                     /product="vWA domain-containing protein"
                     /protein_id="WP_179834070.1"
                     /transl_table=11
                     /translation="MSESGNGNSDAPLDRLVRAAVPGLIVGVVSGLIANQVLKLVDAVG
                     WLQTVLPLTVLALVIVAVSVALFRSERAGAALKRLSRTLPWNAEAVAWACAGAAVMAAV
                     LLAWTGVASLAEHARPCGQPLELRVVTTPETLTSLRDAAKGFEEDSEERGCREYSVTVA
                     PEPEFVQLSEAFGRLWRRSEPPGGEAAPAPQDERLYGPQPDVWIPSSTAEFDYVEKSPD
                     QVRRAQGAGAPSPGPPAKADPVFTTRGSLGSSPMVLALFGGDHAQVEDTAIKPPQQRTT
                     DLLRRFARAGVELREIARPVPETSAAALAVTPVLYGALPGKDQQDEEFAEPTDLVAPDA
                     VTLLCKARQGAHPPDRVAFAVPEQVVSDYDAGRLKKQCGAADAPGAGGEWTLYPYYAED
                     LPSLDHPFIQVTWRGQDTRERDAAVTAFRRWLTRHPLTRQGLRDDKGAMPSAHEGDSAR
                     HDLTALWTLLGPNIIPNRMEPNPLRPAAGDRSGKYVAESLQRVAAARPPASVSLMLDVS
                     GSMGRPARGRDTRLSRSVSFLQSLVAQLQSRDSAGLRVASKKKPPDSPYTLENVRLAGT
                     GPVQKNRITSHLQAVATAGGDVALADMIGKADVDPGSNLVVVTDGQSPGTNGPGSSPGE
                     AAAKFRDRHRDVRVTVVLTGPSGCGASPVKEIVDAFGPSGGKGCVSLTGAPEPQQAAQL
                     LSDLR"
     gene            13880..15250
                     /locus_tag="IEZ14_RS27870"
                     /old_locus_tag="GCM10010177_56210"
     CDS             13880..15250
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024808.5"
                     /locus_tag="IEZ14_RS27870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56210"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_179834069.1"
                     /transl_table=11
                     /translation="MTRRRRWSLPHGRTAWLSAVGGAAATLVCAQALAFWPGSSYEALP
                     SHCDRSELVVAGGTDVSLNSQRRQLIQKWNTGGNPHATLVEIAESTDSQHSQIKAMQES
                     RGCGYDVLIMDNTWTAEFAAGGYLRPLDDIGNRSDFFPAALETGKWHGKQYAVPFNVDV
                     GLLYRRDGAQAPRDWPHLLGSGVAMQLDDYEGLTVNALEAVWNDGGGELLTGERRPDEK
                     TLRTRVFPALKRMAARASDPEPGTRTGGPLTASRSYDEQKSMEAFMAGAPLMRNWPYAF
                     STLATEPGMRDGTRLRYAVAALPGHTVLGGQNLAVSKYSPHPDTALRLVEYLSGTESQK
                     LLFSCGGFAPGRYSALGLRPGRHAAADVQVRSCSAFTQERLDPGDVELDQAQLTELGTA
                     VVNALDRARPRPATPHYSTFTGTFRGCVQKLFDRTGTDAETFARAVGRSLDGRTASC"
     gene            complement(15261..15854)
                     /locus_tag="IEZ14_RS27875"
                     /old_locus_tag="GCM10010177_56220"
     CDS             complement(15261..15854)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634232.1"
                     /locus_tag="IEZ14_RS27875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56220"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_179834068.1"
                     /transl_table=11
                     /translation="MTSHPAEAPPGPPNPRRAEILGAAAELFARRGYHGASIGDLGRAV
                     GLTGPALYRHFSGKEAVLAEMLLDISERLLAEGLRRAADPDPGRALDALLSWHIAFALD
                     NPALITVQERELDNVPEPQRHRIRRLQRAYVEEWVAVLRRLSPRPPDERTRAAVHACFG
                     LLNSTPRSAVQGLDRAAMAGLLHGMARAALEGVR"
     misc_feature    15868..15883
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.97"
                     /tool="antismash"
     misc_feature    15894..15908
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            15933..17546
                     /locus_tag="IEZ14_RS27880"
                     /old_locus_tag="GCM10010177_56230"
     CDS             15933..17546
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132398.1"
                     /locus_tag="IEZ14_RS27880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56230"
                     /product="carboxyl transferase domain-containing protein"
                     /protein_id="WP_179834067.1"
                     /transl_table=11
                     /translation="MSGPEIGSRADVAGEAFKASAAHNEALVAELRDRVDRAGRGGPER
                     ARERHVARGKLLPRDRVDTLLDPGSPFLELSPLAANGMYGDEAPGAGIITGVGRVSGRE
                     CVVVANDATVKGGTYYPVTVKKHLRAQEVALHNRLPCLYLVDSGGAFLPRQDEVFPDRE
                     HFGRIFYNQATMSGRGIPQIAAVLGSCTAGGAYVPAMSDEAVIVRGQGTIFLGGPPLVK
                     AATGEVVTAEELGGGELHARTSGVTDHLAEDDAHALRIVRDIVATLGPREPRPWEVAPP
                     EEPAADPSELYGIVPPDSRTPYDVREVIARIVDGSRFQEFKKEYGATLVTGFARVHGHP
                     VGIVANNGILFGESAQKGAHFIELCDRRSVPLVFLQNITGFMVGREYEAGGIAKHGAKM
                     VTAVACARVPKFTVVIGGSFGAGNYAMCGRAYSPRFLWMWPNARISVMGGEQAASVLAT
                     VRRDQMEARGEEWPAEEEEGFKAPIREQYEAQGNPYYSTARLWDDGVIDPLDTRRVLGL
                     GLSVAANAPLEPVGYGVFRM"
     gene            17555..19492
                     /locus_tag="IEZ14_RS27885"
                     /old_locus_tag="GCM10010177_56240"
     CDS             17555..19492
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634234.1"
                     /locus_tag="IEZ14_RS27885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56240"
                     /product="biotin carboxylase N-terminal domain-containing
                     protein"
                     /protein_id="WP_179834066.1"
                     /sec_met_domain="ATP-grasp (E-value: 3.4e-09, bitscore:
                     30.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 6.5e-08,
                     bitscore: 26.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDSVLVANRGEIAVRVFRTLRRLGIRSVAVHTGADALARHVREA
                     DEALLIPSYLDIEAVIAAARDAGASAVHPGYGFLAENTAFARACGEAGLVFIGPPAGAI
                     DAMGDKIRAKRTVAAAGVPVVPGRDEPGLSDAELEAAALEVGLPVLLKPSAGGGGKGMR
                     LVRDAADLPEAIASARREARGSFGDDTLLAERFVENPRHIEIQVFADAHGGAVHLGERE
                     CSLQRRHQKIVEEAPSPLLDAAARERMGAAAVAAAQAVGYVGAGTVEYIVSADRPDEFF
                     FMEMNTRLQVEHPVTELVTGLDLVELQLRVAAGEPLPFTQDGVRLDGHSIEARVYAEDP
                     ARGFLPTGGRVLALGEPEAARVDSGLDVGTEVGGSYDPMLAKVIVHGADRAEALHRLDR
                     ALASYTLLGVPTNVAFLRALLRHPSVVTGDLDTGLVERALDELVAGASVPPEVLAAAAL
                     ERMLDLESGDDPWDVPDGWRPGAHAWAPWIITPSGGDPVEVRVQGRAGSARVAVGGEPP
                     VAASLTRPFTLTYGGRTTSFAGARDGRTLWLGRDGHAWALSEHVRAEGGADAAAAGDGV
                     LRSPMPGTVLAVKAAEGDRVEAGQPLVVVEAMKMEHTVTAPLAGVVAKLPVRAGAQVAL
                     DAVLAVIEEA"
     gene            19489..20421
                     /locus_tag="IEZ14_RS27890"
                     /old_locus_tag="GCM10010177_56250"
     CDS             19489..20421
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634235.1"
                     /locus_tag="IEZ14_RS27890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56250"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_179834065.1"
                     /sec_met_domain="HMGL-like (E-value: 7.1e-50, bitscore:
                     163.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPVVPLSGLPERVTIYEVGPRDGLQNEKAIVPAEVKAEFVTRL
                     ADAGLRTIETTSFVHPKWVPQLADAEQLLDILPRSPRLRYPVLVPNERGLDRALANGVT
                     EIAIFGSATETFARRNLNRTVDESLAMFAPVVERARAEGLWVRAYVSMVCGDPWEGDVP
                     VEQVVSVASRMMDMGCSQLSLGDTIGVGTPGQVTALIEALTEAGVGTDRLAVHFHDTYG
                     QALANTLAALRAGVTVVDASAGGLGGCPYAESATGNLPTEDLVWMLNGLGVETGVDLAG
                     LVSTSRWMAGRLGRPSPSRVVQALSPESE"
     gene            20425..21573
                     /locus_tag="IEZ14_RS27895"
                     /old_locus_tag="GCM10010177_56260"
     CDS             20425..21573
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657846.1"
                     /locus_tag="IEZ14_RS27895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56260"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_179834064.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 8.1e-39, bitscore:
                     126.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6e-22, bitscore:
                     71.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.4e-49, bitscore:
                     161.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDFTLGEEQEELRRTVEQFARENVAPVIGDLYERGEFPYEIVAA
                     MGKMGLFGLPFPEEHGGMGGDYFTLCLALEELARVDSSVAITLEAGVSLGAMPIYRFGS
                     AEQKERWLPPLTSGERLAGFGLTEPGGGSDIPGGMRTTARLDGDSWVINGSKAFITNSG
                     TDITAFVTVTAFTGDGEISTILVPNGTPGFTVGRKYSKVGWAASDTRELSFDDVRVPAE
                     NLVGERGRGYAQFLRILDEGRIAIAAVSVGLAQGCVDECLRYVREREAFGKEIGRYQAI
                     QFKVADMETRAHTARLAYYAAAARMLAGEPFKKEAAIAKLVASNAAMDNARDATQVFGG
                     YGFMNEYAVGRFYRDAKILEVGEGTSEVQRMLIARALGLPPS"
     gene            21674..22426
                     /locus_tag="IEZ14_RS27900"
                     /old_locus_tag="GCM10010177_56270"
     CDS             21674..22426
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851618.1"
                     /locus_tag="IEZ14_RS27900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56270"
                     /product="FkbM family methyltransferase"
                     /protein_id="WP_179834063.1"
                     /transl_table=11
                     /translation="MLLRAYGIARSLVMYHGIPGRHRRASRLYGEFLGPDDIAFDIGAH
                     VGGRVRVWRGLGARVVAVEPQPDCLRVLRLFFGRDRGVVLVPGAAGAEPGRAHLALSTA
                     TPTVSSMSPGWIKAVTTDRGFARVRWDRSIGVDVTTLDELIAVHGVPAFCKIDVEGFEA
                     DVLAGLSRPLPALSFEYVPSAHDASLEALDLVDRLGDYVYNYSPIETMRLASPRWLDAA
                     ELRRRLERIRPRGRSGDIYARLRESGRP"
     gene            complement(22440..23465)
                     /locus_tag="IEZ14_RS27905"
                     /old_locus_tag="GCM10010177_56280"
     CDS             complement(22440..23465)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS27905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_56280"
                     /product="hypothetical protein"
                     /protein_id="WP_179834062.1"
                     /transl_table=11
                     /translation="MSQTVGIAQFVRQSSDLGECRAGTDLIGRDEVQAFLGSITDVDAA
                     MAELAASLGAGDVFRAGMMAFVCGVLVERGGSVTVPVDAVMEMTERYLGLAKEFVVQGG
                     VSAQDELFRVSPDLVRAHHTLPFVLLAAMTMLSRDEGARRRLRARPHVAPLVDELEEHY
                     ETLYYVREVLALLDGREILLLDPRGRRGFVVGLTGVQDRMYHFFALAQDALERHAGPGY
                     LGAEPTDPALVRYARNQGLTPQEHQEAQELIEHQRIGFHYPGAGGAPAMFFPGSAPFEA
                     VPVVGGLPTLFLDERSIHAQWSPTNMYPVLHEALESRVSLRELPREDVEARLAAFVTSS
                     G"
     gene            complement(23475..24449)
                     /locus_tag="IEZ14_RS27910"
                     /old_locus_tag="GCM10010177_56290"
     CDS             complement(23475..24449)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547821.1"
                     /locus_tag="IEZ14_RS27910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56290"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_179834061.1"
                     /transl_table=11
                     /translation="MSTSIAAGGEGLPLFGFGAHSGVEDVAGLLRMAQQADRDGLDHFS
                     LSDHPYLGERLDAYAAIGFVLGRTERIAGFANVTNLPTRPAPMLARTVTSLSALSGGRV
                     VLGMGAGGLWDRISDMGVPRLSPGAAVDAFEEAIVLVRKLAGGGPPVTHHGRHYRVEEI
                     EPAPVAAPPVWTGSVGPRSLAATGRVADGWIPGHAADWLSERYRTSRPVIDEAAAAVGR
                     DPREIRTIFNLPGRVTDRPLPATRDRDGRWIGGSPEQWAEELTGAVLEHGASGFTLFSP
                     SGGTQDLASVTRWGQEIAPAVREAVAKENGPSPKARRSGPVRR"
     misc_feature    24475..24488
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.54"
                     /tool="antismash"
     gene            complement(24539..25015)
                     /locus_tag="IEZ14_RS27915"
                     /old_locus_tag="GCM10010177_56300"
     CDS             complement(24539..25015)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547820.1"
                     /locus_tag="IEZ14_RS27915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56300"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_179834060.1"
                     /transl_table=11
                     /translation="MGKEDEGRIGVVAALVRGAFLVNAVYGESAREYGITSQQGQLLCV
                     LMARPLGMGELGATLGLAKSSLTGLVDRTERNGLVRREPDPRDLRAVRVALTPEGSRLV
                     EDFYAETCRRIDRLPKGLSDAERGALADLLGRVVLDNQVPVVFAEPDDGAARRR"
     gene            25176..25589
                     /locus_tag="IEZ14_RS27920"
                     /old_locus_tag="GCM10010177_56310"
     CDS             25176..25589
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025445.5"
                     /locus_tag="IEZ14_RS27920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56310"
                     /product="DUF4260 family protein"
                     /protein_id="WP_218935080.1"
                     /transl_table=11
                     /translation="MSAAATRGKVSGIRTVRRAAWSAGALFWTAFAVLEGVNHGWLAAI
                     LAVAFFIAPDLTFLAGLRDAATTERGRLSPRAVPYYNAAHRALVPFALMVVYTVTPVTW
                     APLFAGLCGWMAHISVDRAFGYGLRTKEGFQRH"
     gene            25760..27739
                     /locus_tag="IEZ14_RS27925"
                     /old_locus_tag="GCM10010177_56320"
     CDS             25760..27739
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.5"
                     /locus_tag="IEZ14_RS27925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56320"
                     /product="WD40 repeat domain-containing serine/threonine
                     protein kinase"
                     /protein_id="WP_179834059.1"
                     /sec_met_domain="Pkinase (E-value: 1.1e-42, bitscore:
                     140.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPLHPGDPRRIGPYELEARLGAGGMGQVFLGVSPGGRGVAVKVI
                     RAEHAEDERFRRRFAREVEAARRVGGFHTAQVVDADPEADPPWLVTAFVPGSTLREVVA
                     EHGPLDPDAVRALAAGLAEGLAAIHACGLVHRDLKPGNVIMAADGPRIIDFGIALATDA
                     TVLTSHNVVVGTYAYMSPEQVLGEMPGPPGDVFSLGCVLAYAATGGGPFDATSIPAIVH
                     RVLHEEPDLPGLPGDLSNMIAACLVKDPGRRPALDALISAPQSIEAPAPAPAGPSLPDD
                     DAVGTHANATRVATRQQDAPAVAPAGPAPVRRRALLIGAGAVTAVAAAAVPAALFLTRG
                     DGRQEAAPPAPAPRPKGLVSPSGSLTAPGVKTLNEVAITADGRTVAAGGLDSTITLWDV
                     ATGRVLRTIEKTGWVSALAFSPDGRSLASSCSTPGLLLVWDAATGRLKVNVRSGEFGLN
                     SLDYSPDGRTIAGANPDARLFDAATGRGLASFDLRHSGVNAIAYSPDGGLVAVGVDGYH
                     DKPPGKTVQLLDGRTLRKRGQLVGHTSNLTGVAFSPDGKRLASSGADKTVRLWDLASRR
                     AVRVIKAGEATVKDTRFSPDGSSVLAACSDRTIRIWNAATGVLTATLVGHSQPVERIAL
                     TPDGRTVAGVGGTKADGTVTLWKV"
     gene            27743..29575
                     /locus_tag="IEZ14_RS27930"
                     /old_locus_tag="GCM10010177_56330"
     CDS             27743..29575
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019334.5"
                     /locus_tag="IEZ14_RS27930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_56330"
                     /product="WD40 repeat domain-containing serine/threonine
                     protein kinase"
                     /protein_id="WP_179834058.1"
                     /sec_met_domain="Pkinase (E-value: 1.8e-42, bitscore:
                     139.3, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 7e-07, bitscore: 23.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPLRSDDPRQVGPHRLDGRLGAGGMGEVFLGSSPSGRRVAVKVV
                     RAEYAADPGFRKRFAREIEAARKVGGFHTAQVVDADPEAVSPWMATAFVPGPSLRQVVA
                     RQGPLAPPAVRELGRGLAEGLAAIHACGLVHRDLKPGNVIMAPDGPRIIDFGIARASDA
                     TALTSTGAVVGTFSFMSPEQVRADATGPASDVFALGCVLAYAALGRGPFDAPTIPAIVH
                     KIIGSPPNVAGLTDPPLRDLIVRCLEKEPARRPSVQEILTGLPTEPSRRVPRRAFLLGG
                     AAVAATTAVAVPAVLLWPSDVPAERNVPKTPIGVPTGLVLPSSEVALFDVAFSPDGRSL
                     WGAGFSSILRWDLATAQVTSREMKDTDQTYRRPMVFSPDAGTLATGGADGAVHLWDVAS
                     GRIRKTFTGARGVQALTFGPDGRSLAVSGGNGPGHVQIWDTVTGKTVRMKADYYANALA
                     FSSDGRTLAGGRSYSGRFTLWNVSDGGGTEVSPLNATEVPCLAFSPDGEVVAASTGGYY
                     GYELRNADDGRLKTSIRDLKGEVQALAFSPDGGTLVTADKKNIRLWHVPTGRNTATLPG
                     DADEEQSVTFSPDGQSFATTSGAGTTHLWTFAPA"
ORIGIN
        1 ccgaggtcta cggctacctg ctgccccggt gcggccggcg cgccctggcc gaggacctga
       61 ccgccgagac cttcctggcc gccgtggagg cgctgcgcaa ggagcctccc ccggtgctgt
      121 cggtcgcatg gctcgtcggc gtggcgcggc acaaactggc cgaccactgg cgccgggcgg
      181 cgcgggagca acgcggtctc caggccttgg acgggggcgt cctggacgcc gcggaagacc
      241 cgtgggacga acgcctggac gccctcgtcg cccgagacgt cctcgacacg ctggcgcctc
      301 accacagggc agccctgacg ctgcgctacc tcgacgggct gcccgtcccg caggtcgccg
      361 aacatctggg ccggacgctt cacgcgaccg aggcgctgct gacacgggcg cgcaaggcct
      421 tccggcgggc ctacaccgac cactgtccac cagggagacg ggtccccggg caccccggcg
      481 gaaaggaggg ccacgatgac tgatccgctg gaggctctcc gcacgccggt cgtcccagtc
      541 gatcccgacc cggccttcgc ggcgcggctg cgtgaacgcc tgcggcgcgc gctgctgcaa
      601 cccacaggag aaaccatgac gacgaccacc gttcgtgaaa cgcaggccga ggtgcggtcg
      661 ctcaccccct acctgtgcgt cgacgacggc cggcgcgccc tgcgctggta cgcggaagcg
      721 ttcggtgccg agctccgggg cgagccgatg gtgatggaag acggacgtgt cggtcacgcc
      781 gagctcgtca tcggcgactc cgtcctgatg ctcgccgacg agtggccgga gagcggcctg
      841 ctcgggccga aggcacgcgg cggccccagc cagtcgctct acctgaacgt ccccgacgtg
      901 gacatcgtct tctcccacgc cgtcgaaatg ggggccgtcg cccatcgccc cgtggccgac
      961 tacccctacg gccgcaatgg cgttgtgatg gacccgttcg gccaccgctg ggtcatcgca
     1021 ggccccccgc tgcccgcacg tccgcggcta cggcacggcg acgtcggata cgcctcggtc
     1081 tgggtccccg acgtggaccg cgccgccgcc ttctatggct ccgtcctcgg ctggcacacg
     1141 gtccccggag gcgcggaggc cggtcgtcgc gttgaaggac tgcccgaaca gcacatcggt
     1201 ctcttcggcg ggcaggagca ccgcaccgtc tacctggcct tcgcggtcga ggacgtccac
     1261 ggaaccgtcc ggcagatccg cgatgccggt ggtgacgccc aagagccgac cgacgagcct
     1321 ttcggtgtca gcgccatgtg cacggacgac cagggcctgc gcttctcggt ctaccagccc
     1381 gcggaggcgg tcagtcccgt cgagggccgg ctcgcggaag cagcggggct caccgctcac
     1441 cacggcgaga tctcctacct caccatcggc gtccccgaca tcgcccgtgc acgctccttc
     1501 tacggcgagg tgctgcactg ggagttcacg ccgggccaca cgccgggcgg ctggagcgtc
     1561 cgcctcggcg gaacggaggt ccgccccatg acgggtatgt acggtggcgc cgaccatccc
     1621 gtggtggtcc cgatgtacac ggtcgacgac atcgagcccg ccgtcgcccg cgtccgcgag
     1681 gccggcggca ccgctaccga ccccgcccga cagccctacg gcgtcacctc cgaatgcacc
     1741 gacgatcaag ggagccgctt ttacctgggc cagcactgac gtcccgcccc gaacgcgatt
     1801 cccttccctc ctccctcact accgacgcct tacaccacct ctcgcccggg cgcgaagtcc
     1861 gagttcagcg acccatgggt gtccctaggg aaatgacggg ttaggtatgt gtccgccgga
     1921 ctgggctgaa aggacagggt gctgggtaga aatcgaatgt gtctggtggg ctggttggtc
     1981 gacgggcttt agcgtcggat tggctggtat ggacagcgaa gagcgcgcgc ttggggtgaa
     2041 ggcacgccgt acgcggcgag cctccgagcg cgcagcgaca acgcggctgc ctgaaggtcc
     2101 cgaagcccct gcgacggcct cggagtgcag gcccggggcc gaggagtacg cgcggcaggc
     2161 gatggtctca tcggcgggag cccacgaccg cgccgcgttg ctcctggagg agatggccac
     2221 cgtccacccc gaagaggccg agttgcacct ccagtcagcc gcgcgccacc gccgatgggc
     2281 agacaatgac aggagactgg cccggcaaca cgcaccaggc ggcagcgaaa tcgacgccac
     2341 ctgaccacag gcttttccgt tggcagcacg cccttacggc ggcacggcgt cgcagggggc
     2401 caaggtatct cggcgctcca ccgcaccgcc gtcccgcacg acttcacctg gtccgatcgt
     2461 ctggctcgcg ccccgtgtct cggcgatcga gtgcgcgacc tccgccgtcc tccacgccga
     2521 tccggtgatc agcgccgcga cgaccttggc gacggcgata ccgaggttgg cgacggcgat
     2581 gcctggtctt tcggcttgcc ggggtccgcc ttgtgacggt cgggggtaga gcgcttaggt
     2641 agggaggggt catgtaagga tccggttatc tctctgggag gtcctggtgc gggttggggt
     2701 tctgctcaac gagcggggcg gcgtcgaggc gctggggaag ctggcggacg atgtgcggcg
     2761 tgcggtggac gacgggttct cctcggcgtg gatgtcgcag atcttcgggt tggacgcgct
     2821 gaccgcgctg gccgtggcgg gcagcggggt gtccggcatc gagctcggga cggcggtcgt
     2881 gcccacgtat ccgcggcatc cggccgtgct ggcgcagcag gcgaggacga ccgcgctggc
     2941 gctgcggggg cggttcacgc tcggcgtcgg gctgtcccac cagatcgtca tcgaggagat
     3001 gtacggatac gacttcggca ggccgctgcg gcacatgaac gagtacctgt cggtgctggc
     3061 gccgctgctc gaaggggaga acgcctcctt cacgggcgag acgctgcggg gcaacgtcgg
     3121 gttgagcgtg ccgaacgagg ggcgggtgcc gctgctgctg gcggcgctcg gcccgaagat
     3181 gctgaagctg gcggcggagc gggcggacgg gacggtgctg tggatgaccg gtcctggcac
     3241 cgtccgcgag cacatcgtgc cgaccatcac ggcggcggcc gaggcggccg gacgggacgc
     3301 gccgcgcgtc gtgtgcgtcc tgcccgtgtg cgtcaccggt gacgtggagc gcgcgcggga
     3361 gcaggccggg gagacgttcg aggtgtacgg ggtgctgccg tcctaccggg cgatgatgga
     3421 ccgggaaggc gtggcggggc cgaaggacct tgccgtcgtc ggggacgagg acgcggtcgc
     3481 ggcgaagctg gaggagctgt ccgaggcggg cgtcaccgac ttcgtcgccg ccgagtacat
     3541 gcccggcgac cggcgcaccc gggagttcct gaagacggtc acggcgaaat gacctcgtag
     3601 aggttgccgc tggcgtcaga gaagtagagg ccgcggccgc cgagcgggtg gttctcgtcg
     3661 acacggccgt tgtcggcgtg ggcggggccg tcgccatagg ggatctcacg ggcgtcgagg
     3721 cggtccacga ccgtgtcgaa ggtgacggcg tccacgtcga aggccaggtg gtggccctgc
     3781 gggtaggcga ccgtcatgaa gtcgagggtg aggccctcat tcacccggat cgggacgaag
     3841 tggcgcgcgt gcgggtgcgg gccggtgtac tccaggccca tgacggcggc gaagaagcgg
     3901 gcggcctcgt cgttgtctgc ggccgtcacg atcgcgtggt tcagggtgat cgtcatgctg
     3961 tgtttccttc cttgagagcg ccgtgcagga agacgtccag gtactcctcg acggagaggg
     4021 gctgcgcgtc gggggcggcg gcgggccggg cgcggctgaa cacgaagccc aggaacaggc
     4081 tcgcgatctg ctcgacgggt aggcgcagcc ggtcccgttc gggttcgaac agctcggcga
     4141 gcgcttcgca ggtgcgggtc atggcggcgg cacggtcggg gccgggctcg ccggagcccg
     4201 gcacgcggcg ctcgcgccgg ccggtggcgt gcagagcgcc gatcaccagg cccatgcggg
     4261 cgaggtaggc gtcgatcgcg gcggcggcct cggcaagccg cgcgggcagc ggctggtcga
     4321 gcgggatcgc gccgatctcg gcgaggacga ggtcggtccg cagtgcctcg gcgacgcagg
     4381 cgtccagcag ttcgtccttg tcggcgaaca cgcggaagat cgtcgcctcg ccgatgcccg
     4441 cggcgcgggc gatctgggcg gtggtgacgg ccatgccgtg ctcggcgacg agcggcagcg
     4501 cggtccggat gatcatttcg cggcgctgtt ccgggctcat cccgggggcg cgccggcgga
     4561 ccttctcctc catgtccgcc accgtacgga gtgagtactc actccgtcaa gaccgaagtg
     4621 agtactcact ccgcacaatc cgacagatca gcattcggtg gctgataccg ttgcgatgct
     4681 gcgcgccagg agcgaagtcc ggtggaaaat ccggcgctgt cccgcaactg tggtgcccct
     4741 ctcgaagtgg ccgagccagg tcgcctcctc gcgcgccgac gattgtcgac ctcgtggaag
     4801 ggcgatccgt cctgacgggc cgcggcttcc ctgcaaccag gaggctcctg tgagacccgt
     4861 acgcaccttg ggcgcggcga tggcgatcgg catcgtcacg ttcgccgcca ccgcatgcgg
     4921 cggcgacgac ggcaagaccg gcggcacgcc ggacgggaac accatcaccg ttcaggccgc
     4981 caacggagcc gtggccgtcc cggccaagcc gaagcgcatc gtctccctgt cccccacgca
     5041 caccgagacg ctcttcgcca tcggcgccgg accgcaggtg gtcgcggtgg acgactactc
     5101 caaccacccg gccggcgccc cgcggacgaa gctgtcgggc ttcaagccga acgccgaggc
     5161 gatcatcgcc tacaagccgg acctcgtcgt gctgtccgac gacctggacg gcatcgtcaa
     5221 gtcgctggag aaggtgaagg tccccgtcct gctggagccg gcggcgacga acctggacga
     5281 ggcctacgac gagatcggcg acctcgggca ggccaccggg caccaggccg aggccaagaa
     5341 ggtcaccgac ggcatgcgcg cggacatcca gaagacggtc gccgcgtcgt ccaaggccaa
     5401 gggcctcacc tactaccacg agctggacaa ccagctccac tcggtgacgt ccaagacctt
     5461 cgcgggccag gtgtacgcgc tcttcggcct gcagaacatc gcggacaagg cggacaaggc
     5521 gtccggcggc tacccgcagc tgtcccgcga gtacctgctc aagcaggacc ccgacctgat
     5581 cttcctggcc gacaccaagt gctgcgggca gaacgccgcg gccctcacca agcgccccgg
     5641 ctggtcggac ctggacgccg tcggccacgg cggcgtggtg gaactcgacg acgacatcgc
     5701 ctcccgctgg gggccgcgcc tgacggagtt cgtcaaggcg atcggcgacg cggtccagaa
     5761 ggttcagtga ccgctgccgc cgaggacgcc cgcccgtgag caggcgccga ccgcacaccg
     5821 gggacgtccc ggccgacgcc gaggacgcgg acgggacgtc cccggacgtc cgcacaggtc
     5881 ccaaggacgt ctccaggcag gggcgggcac ccgaggtctc ctgcgaccgc ggcgatgcgc
     5941 cgcccgaggc gacgacgcac cccgggggcg tcgtcccctc gggccttgac ggctcacccc
     6001 ccggccggca gggccaggcc aggctgcggc cactgccgct ggcggtggcg gtcgggctgc
     6061 tgctcgcgac gctgctggcg ggggtgctgg tggggtcggc cgggctgccc gtcggcgggg
     6121 tcctgaaggc gctggccgac aggatcccgt tcgtgcacgc cgacagcggg ttcggcgtca
     6181 tcgacgagaa cgtgctgttc cagctgcggg tgccgagggc cctgatggcg gcactggtcg
     6241 gcgggatgct cgccgtcgcg ggcgccgggt accagggagt gttccgcaac ccgctcgccg
     6301 acccgtacct gctgggcgcg gcggcggggg cgggggtcgg ggcgacgctg gtcatcgcgc
     6361 tcgtgccggg cgaccccggg tacacggtgc cgctcgcggc gttcgtcggc gcgatcggcg
     6421 gggtggcgct ggcctacgtg ctgggcagcg tcgcgacggg gcgcgggaac gggacggcga
     6481 cgctggtgct ggccggcgtc gcggtgtcgt ccttcctcgc cgcggtgcag acgctgatcc
     6541 agcagatgaa gtcggaggaa ctgcagcgga tctactcgtg gatcctcggc ggggtcggat
     6601 cggccgactg gcaccagctg gcgctcgtct tcccgtacgc gctggtctcc accgtggtgc
     6661 tcctcgccca cggccggctc ctggacgtgc tgagcgtcgg cgacgaggag gcggcctcgc
     6721 tcggcctgtc ggcggcgcgg gtccggctga cggtgctggt ggcggcgtcg ctggcgacgg
     6781 cgtcggcggt cgcggtgagc gggctgatcg ccttcgtcgg catcgtcgtc ccgcacgtgg
     6841 tgcggcggct ggcgggcggg tcgtaccgga tcgtgctgcc gctgtcgctg ctgggcggcg
     6901 cggcgttcct ggaggtggcc gacctcgtgg cgcggacggt catcaggccc ggggaggtcc
     6961 cgctgggcgt ggtgacggcg ttcgtcggcg ggccgttctt cgtcgcggtg ctgcgcgcgt
     7021 cccgccggca ggtggagacg tgaccgtctc ggtgcggggc ctggacgtcg cgctcggcgg
     7081 gcgccgggtg ctgaagggcg tgtcgctgga ggtcccggcc gggtcgtgga cggcggtcat
     7141 cgggccgaac ggcgcgggga agtcgacgct gctgcgcgcg gtcctcggcc tggtgccgtc
     7201 ccatggcgag atcagcctcg cgggcgcgga cctgcagtcg ctcaagccga ggcagcgcgc
     7261 ccggctcgtc gcctacgccc cgcagagccc gagccttcca gtgggcatga cggtgtacga
     7321 ctacaccctg ctggggcgct ccccctacat cccgcatctg ggccgggaga gcgcccgcga
     7381 ccgggccatc accggagagg tcctcgaccg gctaggcctc acccccttcg cgtcacgccc
     7441 cctggaccac ctctccggcg gtgagcggca gcgcgtggtg ctggcccgcg ccctcgcgca
     7501 gcagacctcg gtgctgctgc tggacgagcc gacgaccgcg ctcgacatcg gccaccagca
     7561 gcaggtgatg gagctgatcg accggctgcg gctgtcggac gggctgaccg tggtgaccac
     7621 gatccacgac ctgacgctcg ccgggcagta cgccgacggg ctcgtcctca tctcgggggg
     7681 acgggtggcc gcgtcgggcc cgcccggcct ggtcctcacc cgcgacgcgg tcgaggagca
     7741 cttcgacgcc cgcgtgagcg tcacccccgg gccgggcggc cggccgatcc tgtcgctgga
     7801 gcgtccgtga acctcgaaac ggtgtggcgg gtggaggacg gcaggcggct cgcctccacg
     7861 gtgtggcggg ccggccgcgg ccatcggatg atctcctcgg cgatgctggg cggcggcatc
     7921 ggcccggccc gctgggtgct gaacgcccag gtgcccggcg cctacgcgcg caccgacccg
     7981 gtcgcgcacc tcgccgaact cgcggcggcg ggcgggctgg agggccccgg cgtcgggatg
     8041 ctcacggctg cctcggtggc gcgaacggtg cggcgggacg gggagggcgt gcgcgtgtcg
     8101 gcgacggtcg ggctgcgcgt cccgacctgg gcggcctccc ccgccggggc gcccgatccc
     8161 gaactggccc cgctggacgg ggacgcgacg ccggcctgga agcccgggac gatcaacatc
     8221 gtggtcgcag tccccgtcca gctgagcgac gcggcgctgg tgaacgcggt cgtcaccgcg
     8281 accgaggcca agacgcaggc gctgctcgaa gcgggcttcc cctgcacggg cacggcgtcc
     8341 gacgcgatct gcgtcgcggc cgcggccggc ggaacgccgg aggtcttcgc cgggccccgc
     8401 tccacctggg gcgcgcggat cgcacggacc gtgcacgccg ccgtccgcgc cggggccctg
     8461 gactacgcct cccgtctgga ggcacgcggc tagccggccg ccgtaccacc ccggtgcggt
     8521 acggcggccg gtctcagggc cagtgcagtg tgggggttgg gcctcacctc ctacctgtgc
     8581 gtcgcgcctc cggcatgacg gtcagccggc gtggggaagg cgatgcccgt tgtgtccacc
     8641 gtgcccgttg cggcgcaggg ggtcggtggc gagcgggtcg ccgccgtcca gcagggaccc
     8701 gttcatcggc ggcagggagt gcaggccggt cggcggctcc cggtcgacgg cggggcgcgg
     8761 cccggccggg ccggggtccg cgcgcccctc cgacagcgcg gtgagcgcgt cgacgcggcg
     8821 gcgcgcgcgc tcggcctcgg cgcgggcggc gtcccgctcg gcggtcagcg ccctcaccgt
     8881 ggcgcgcagc tcctcgaccg cgcgggcgag ctgccagttg tgccgctcca gctcgctggc
     8941 ccgtgcctgg atctggtcgc ggtcggccac ggcctgcccc cgcttggcct cggcgtcgcg
     9001 gacggcggag cgcaggtcct cggcggcacg ggtggcggcg gcggcctcga cgcgctgccc
     9061 ctcgacgagg gtgtcggcct ccgacagccg cccgtgcagg gtgacgagtt cggcgcgggc
     9121 gctctccagg gaggcgagca gctcgccctc ccgggaggcc atgcggtcgc ggtcgcgctc
     9181 ggcggcgatg cgggcggcgc cggcgccgtc ggcgtcgtct tctgcctcct ggcgctcccg
     9241 ccgcgcggcg tcccgttcgg ccgcgagccg ttcggcctcg gcgcgggcgg acgccgcctc
     9301 ctgctcggcg gcctcggcgc gggcgcgggc ggtggccgtc tcgcgccacg ccacctcggc
     9361 ctgccgctgg gaggcgtcgc gctcccgctg ggcgatcgcg acgagcccgg cggcctcggc
     9421 gcgggcctcg gcgatccgcc gctcgacgcc cgccacgctc agctcggaga tcagcgaccc
     9481 ggcgagccgg tcggcgaggc cctccagccg gtcgaccatc tcccacgtcc aggcgacctg
     9541 gccggtgagt ccgggcgcct ccagcccgcg ctcccggctc tcgcgcgccg cccgctcgca
     9601 cgtgccgtcg ccgtcctggc agtagcggac ggtgcgggcg ccgcgcaccg gctgcggcac
     9661 gggccgtccg cagccggcgc acggccagac cgcgaccggg tcaccgaggc gtgcgatccc
     9721 ggcgcggtcg tcttcggggg ccggcggctc ccccgcgccg cccggcggga cgtccggcag
     9781 cgcacccgag gacccgcgcg gacgcgccgg gtcgtccccc tcggcgtagg cggcagggtc
     9841 ggtgatgacg ggaaggtcgg tctgcgtcgg ggcggcgggg gtcggggcga cgttgtcgaa
     9901 cggggcgacc ttctggtctt ccatgtgcgg ttgtacgcac catggcccgg aggcgttcga
     9961 cgttcccggc gacgagttga ctcccggccg tccggcaggc tcagtccgcg cgttggccca
    10021 ggtaggcctc ccgcacgcgg cggcggctga gcttgccgga cggggtgcgc ggcagcgatt
    10081 cgcggaattc caggcgccgg gggtgcttca gtttcgccag ccggggggcg cagtgcgcga
    10141 gcagttcggc ggcgagcccc tctcccggtt cggcgtcctc ggcgggctcg acgagcgcga
    10201 cgacgcgttg cccccagtcg tcgtccggga cgccgatgac ggcgacgtcg gcgaccgccg
    10261 ggtgctggag caggacggac tcgatctcgg cgggatagac gttgaccccg ccggagatga
    10321 tgaggtcggt gcggcggtcg ctcatgtaga gccagccgtc ctcgtcgagg tggccgaggt
    10381 cgccgggggt gtagtagtcg tcccgcatgg cggccgcggt cttggccggg tcgccgtggt
    10441 actcgaagcc gggctgcccc gtcgcgtaga tgaggccggt ctcccccggc ggcagctcgg
    10501 ccccctccgg atcgaggatc ctgatccgca cgccgtcgac cgcgcgcccg acggtcccgg
    10561 gacgggcgag ccactcgtgc ggggtcgcga cgacgaccgg gccgctctcg gtggagccgt
    10621 agtactcgta gaggacgggc ccccaccact ccatcatcct ctgcttcgtc tccacgggga
    10681 cgggtgcggc gctgtggtac acctggcgca gcgtcgacag gtcgtaccgg gcgcggacgc
    10741 cgtccggcag ggccagcatc cggtggaaca tcgtcggcac catgaacgtg ttggtgacgc
    10801 cgtgccgctg gaccagttcc agggtgtgct cgggatggaa ccgcggggcg acgacgacgg
    10861 cgtgtccgag gttcagcgcc atcatcgcgt ggacgcaggg cgcggagtgg tagagcggtc
    10921 caacggcgag gtgcacctcg tcgccgggct ccagcccgag gtgcctcccc agcgtccgcc
    10981 gcatgatgtc catcagcacc tcgggcgcga tgtcgagcag cggccgccgg acccccttcg
    11041 gtcgccccgt cgtcccggag gtgtacagca tgaccgagcc catgcgccgg cgggcgggcg
    11101 gttccgcgct gcccgtcgcg cagagcgcgg ccatcgaccc gtacccgtcg ccggcgtcga
    11161 cgctcacccg tccctcggcc gggacgcccg cctcgtcggc cgcgccggac accgcctcgg
    11221 ccagcgcgct ctcggtgatg acggccttcg cgccgctgtc gcccaggatg tagccgatct
    11281 cgggcgcggt caggtggcgg ctcaccggga ccaggtacag gcccgactgg accgcggcga
    11341 gcaggacggt gaggaactcg ggccggttgc cgaggacggt cgccagagtg tcgccggggc
    11401 gcagccccat cccggccagt gcgttggaga ggcggttgac ctcggcgagc agttcgccgt
    11461 aggagatcgg tacgcccggg gccagcacgg cgggacggtc cgggtcgttg cgcgcgatct
    11521 cgtagaagcc gacaccctcg acgcccatgc gggtctcctc cgtgcgggac ctgaaaccga
    11581 atcctgttcg accatctgat ccggggggcg ccgggagagt caaggtcatc cgcggccggg
    11641 ccgcccgcgg cgggaaagat cgtccgatgc aggacaggcc ttttccatga ccttgctcgt
    11701 cccggcaatt atcattggcc gtcagatcga aggacgatac atcgtgcttt ccgcggcgac
    11761 ggagccggaa tgagtgagtc gggcaacggg aactctgacg cgccgctcga ccggctcgtg
    11821 cgcgcggcgg ttcccggcct gatcgtcggc gtggtctccg ggctgatcgc caaccaggtg
    11881 ctgaagctgg tcgacgcggt cggctggctg cagaccgtcc tgccgctgac cgtcctcgcc
    11941 ctggtgatcg tggcggtgtc ggtggcgctg ttccgctccg agcgggcggg cgccgcgctg
    12001 aagcggctct ccaggaccct gccctggaac gccgaggcgg tggcgtgggc gtgcgccggc
    12061 gcggcggtca tggcggcggt cctgctcgcg tggacgggcg tcgcctcgct ggcggagcac
    12121 gcgcggccgt gcgggcagcc tctggagctg cgggtcgtca ccacgccgga gacgctcacc
    12181 tcgctgcgcg acgccgcgaa gggcttcgag gaggacagcg aggagcgggg ctgccgggag
    12241 tacagcgtca ccgtcgcgcc ggagccggag ttcgtgcagc tctccgaggc gttcgggcgg
    12301 ttgtggcggc gcagcgagcc tcccggcggc gaggcggcgc cggcgccgca ggacgagcgg
    12361 ctgtacggcc cgcagcccga cgtctggatc ccgtcgtcga cggccgagtt cgactacgtg
    12421 gagaagagcc cggaccaggt ccgcagggcg cagggcgccg gtgccccgag cccgggcccg
    12481 ccggcaaagg ccgatccggt gttcaccacg cgcggctcgc tggggtcgtc gccgatggtg
    12541 ctggccctgt tcggcggcga ccacgcccag gtggaggaca cggccatcaa gccgccgcag
    12601 cagcgcacca ccgacctgct gcggcgcttc gccagggcgg gcgtggaact gcgcgagatc
    12661 gcccgtcccg tcccggagac gtcggccgcc gccctggcgg tgacgcccgt gctctacggc
    12721 gcccttccgg gcaaggacca gcaggacgag gagttcgccg agcccaccga cctggtggcg
    12781 ccggacgcgg tgacgctgct gtgcaaggcc cgccagggcg cccacccgcc ggaccgcgtc
    12841 gccttcgccg ttcccgagca ggtcgtcagc gactacgacg cgggacggct caagaagcag
    12901 tgcggcgccg cggacgcgcc cggcgccggg ggcgagtgga cgctgtaccc ctactacgcc
    12961 gaggacctgc cgtcgctcga ccacccgttc atccaggtga cgtggcgcgg ccaggacacg
    13021 cgggagcgcg acgcggccgt caccgcgttc cgccggtggc tgacccgcca tccgctcacc
    13081 cggcagggcc tccgggacga caagggcgcc atgccgtccg cgcatgaggg cgactccgcc
    13141 cgccacgacc tgacggcgct gtggaccctg ctcggcccca acatcatccc gaaccggatg
    13201 gagccgaatc cgctgaggcc ggcggccggc gaccgcagcg ggaagtacgt ggccgaaagc
    13261 ctccagcgcg tcgccgcggc ccgtcccccg gcctcggtct ctctcatgct ggacgtgtcg
    13321 gggtcgatgg gtcgtccggc ccggggccgc gacacccgtc tgtcgcgaag cgtctccttc
    13381 ctgcagagcc tggtggccca gctgcagagc cgcgacagcg cgggactgcg ggtggcgtcg
    13441 aagaagaagc cgcccgacag cccgtacacc ttggagaacg tgcggctcgc cgggacgggc
    13501 cccgtccaga agaaccgcat cacgagccac ctccaggcgg tcgcgaccgc cggtggcgac
    13561 gtcgcgctcg ccgacatgat cggcaaggcc gacgtggacc cggggtcgaa cctggtcgtc
    13621 gtcaccgacg ggcagtcccc cgggaccaac ggccccggtt cgtcccccgg cgaggcggcc
    13681 gcgaagttcc gtgaccggca ccgggacgtg cgggtgaccg tggtgctgac gggcccgtcg
    13741 ggctgcggcg cctcccccgt caaggagatc gtggacgcgt tcggcccctc cggcggcaag
    13801 ggctgcgtgt cgctgacggg cgcgccggaa ccgcagcagg ccgcccagct cctctccgac
    13861 ctgcgatgaa cggagggcca tgacgcgacg gcggcgatgg tccttgcccc acgggcggac
    13921 ggcctggctg agcgccgtgg gcggggccgc ggcgacgctg gtctgcgccc aggcgctggc
    13981 cttctggccg ggctcctcct acgaggccct gccgtcgcac tgcgaccgct cggagctggt
    14041 cgtcgcgggc ggcaccgacg tcagcctgaa cagccagcgc cgccagctga tccagaagtg
    14101 gaacaccggc ggcaacccgc acgccacgct cgtggagatc gcggagtcca ccgactccca
    14161 gcacagccag atcaaggcga tgcaggagtc gcgcggctgc ggctacgacg tgctgatcat
    14221 ggacaacacc tggacggcgg agttcgccgc gggcggctac ctccggccgc tcgacgacat
    14281 cggcaaccgg agcgacttct tccccgccgc actggaaacc ggaaagtggc acgggaagca
    14341 gtacgccgtc ccgttcaacg tcgacgtcgg gctcctctac cggcgtgacg gcgcgcaggc
    14401 cccgcgcgac tggccgcatc tgctcggctc cggcgtcgcg atgcagctcg acgactacga
    14461 ggggcttacg gtcaacgcgc tcgaagccgt gtggaacgac ggtggcggcg agctgctcac
    14521 cggtgagagg cgcccggatg agaagacgtt gcggacgaga gtgttcccgg cgttgaagag
    14581 aatggcggcg cgcgcctccg acccggagcc cggcacgcgt acgggcggcc cgttgacggc
    14641 gtcgcgctcc tacgacgagc agaagagcat ggaggcgttc atggccgggg cgccgctgat
    14701 gcggaactgg ccgtacgcgt tctccacgct cgcgacggaa ccggggatgc gggacgggac
    14761 gcgcctgcgg tacgcggtgg ccgccctgcc cggccacacc gtcctcggag gccagaacct
    14821 cgccgtctcc aagtactccc ctcacccgga caccgcgctc aggctggtgg agtatctgag
    14881 cgggaccgag agccagaagc tgctgttctc gtgcggcggt ttcgcgccgg gacgctacag
    14941 cgcgctcggg ctgcgccccg ggcggcacgc cgccgccgac gtgcaggtgc ggagctgctc
    15001 ggccttcact caggagcgcc tcgatcccgg cgacgtcgaa ctcgaccagg cgcagctgac
    15061 cgagctgggg acggccgtgg tgaacgccct ggacagggcg cggccccgtc ccgccacgcc
    15121 gcactacagc acgttcaccg gcacgttccg cgggtgcgtg cagaagctct tcgaccggac
    15181 ggggacggac gccgagacgt tcgccagggc cgtggggcgc tcgctcgacg ggcgcacggc
    15241 gtcctgctga ccgtgctcgg ctagcggacg ccttcgagtg ccgcgcgggc catgccgtgc
    15301 aggaggccgg ccatcgctgc gcggtcgagc ccctgcacgg cgctgcgcgg ggtggagttg
    15361 agcaggccga agcaggcatg gacggcggcg cgggtgcgct cgtccggcgg ccgggggctg
    15421 aggcggcgca ggacggcgac ccactcctcg acgtaggcgc gctggagccg gcggatgcgg
    15481 tggcgctgcg gctcggggac gttgtccagt tcccgctcct gcacggtgat cagcgcgggg
    15541 ttgtcgaggg cgaacgcgat gtgccagctc agcagcgcgt cgagggcgcg cccggggtcg
    15601 gggtcggcgg cgcggcgcag gccctcggcg agcagccgct cgctgatgtc gaggagcatc
    15661 tcggcgagca ccgcctcctt gccgctgaag tggcggtaga gggcggggcc ggtgagcccg
    15721 acggcccggc cgaggtcgcc gatggacgcc ccgtggtagc cgcggcgcgc gaacagctcg
    15781 gcggcggcgc cgaggatctc ggccctgcgc gggttgggcg ggcccggcgg cgcctcggcg
    15841 gggtgggacg tcatgcggcc cagtctagac tagagttgtt aacgaccgtt aacatcagca
    15901 ttgttaatga acgttaactg ggaagggggg tcatgagcgg acccgagatc ggctcgcgcg
    15961 ccgacgtcgc gggcgaggcg ttcaaggcga gcgccgcgca caacgaggcg ctcgtcgcgg
    16021 aactgcgcga ccgcgtcgac cgggcgggcc gcggcggacc cgagcgcgcc cgcgagcggc
    16081 acgtggcgcg cggcaagctg ctgccccgcg accgggtcga cacgctcctg gaccccggct
    16141 cgcccttcct ggaactgtcg ccgctggccg cgaacggcat gtacggggac gaggcgccgg
    16201 gcgcggggat catcaccggc gtcgggcggg tctccggccg cgaatgcgtc gtcgtcgcca
    16261 acgacgccac cgtcaagggc ggcacgtact acccggtcac ggtgaagaag cacctgagag
    16321 cgcaggaggt ggcgctgcac aaccgcctcc cctgcctcta cctggtcgac tccggcggcg
    16381 cgttcctgcc gcgccaggac gaggtgttcc ccgaccgcga gcacttcggc cgcatcttct
    16441 acaaccaggc cacgatgtcg ggccgcggca tcccgcagat cgcggcggtg ctgggctcct
    16501 gcacggcggg cggcgcctac gtcccggcga tgagcgacga ggccgtcatc gtccgcggcc
    16561 agggaacgat cttcctcggc gggccgccgc tggtgaaggc cgccaccggc gaggtcgtga
    16621 cggcggagga gctgggcggc ggcgagctgc acgcgcgcac gtccggcgtg accgaccacc
    16681 tcgccgagga cgacgcgcac gcgctgcgga tcgtccggga catcgtcgcc acgctgggtc
    16741 cgcgcgagcc gcgcccgtgg gaggtcgcgc cgcccgagga gccggccgcc gacccgtccg
    16801 agctgtacgg gatcgtcccg ccggactcgc gcacccccta cgacgtgcgc gaggtcatcg
    16861 cccggatcgt ggacggcagc cgcttccagg agttcaagaa ggagtacggc gcgacgctcg
    16921 tcaccgggtt cgcgcgcgtc cacgggcacc cggtcgggat cgtcgccaac aacggcatcc
    16981 tgttcggcga gtcggcgcag aagggcgcgc acttcatcga gctgtgcgac cggcgcagcg
    17041 tcccgctggt gttcctgcag aacatcaccg ggttcatggt cgggcgcgag tacgaggcgg
    17101 gcggcatcgc caagcacggc gcgaagatgg tgaccgccgt cgcgtgcgcc cgcgtcccga
    17161 agttcaccgt cgtgatcggc ggctcgttcg gcgccggcaa ctacgcgatg tgcggccggg
    17221 cctactcgcc gcgcttcctg tggatgtggc cgaacgcccg catctcggtc atgggcggcg
    17281 agcaggcggc gagcgtcctc gccaccgtcc gccgcgacca gatggaggcg cgcggcgagg
    17341 agtggcccgc cgaggaagag gaagggttca aggcgccgat ccgcgagcag tacgaggcgc
    17401 agggcaaccc gtactactcg acggcgcggc tgtgggacga cggggtgatc gacccgctcg
    17461 acacccggcg cgtgctcggg ctcgggctgt cggtcgcggc caacgcaccg ctggagccgg
    17521 tcggctacgg cgtcttccgg atgtgagggt gttgatgttc gacagcgtcc tggtcgccaa
    17581 ccgcggggag atcgccgtcc gcgtgttccg cacgctgcgg cggctcggca tccggtccgt
    17641 ggccgtgcac accggggccg acgccctggc gcgccacgtc cgggaggcgg acgaggccct
    17701 gctgatcccg tcgtacctgg acatcgaggc ggtcatcgcg gccgcccgcg acgccggcgc
    17761 gtcggccgtg caccccggat acgggttcct cgccgagaac acggcgttcg cgcgggcgtg
    17821 cggcgaggcg gggctggtgt tcatcggacc gccggccggg gcgatcgacg ccatgggcga
    17881 caagatccgc gcgaagcgga ccgtcgcggc ggccggcgtc cccgtggtcc ccgggcggga
    17941 cgagcccggc ctgtccgacg ccgaactgga ggcggcggcc ctggaggtcg ggctgccggt
    18001 gctgctcaag ccgtccgcgg gcggcggcgg gaagggcatg cggctcgtcc gggacgccgc
    18061 ggacctgccg gaggcgatcg cctccgcccg gcgggaggcg cgcggctcgt tcggcgacga
    18121 cacgctgctc gccgagcggt tcgtcgagaa cccgcggcac atcgagatcc aggtcttcgc
    18181 ggacgcgcac ggcggcgccg tccacctcgg cgagcgcgag tgcagcctcc agcgccggca
    18241 ccagaagatc gtcgaggagg cgccgtcccc gctgctggac gccgccgcgc gcgagcggat
    18301 gggcgccgcc gccgtggccg ccgcgcaggc cgtcgggtac gtgggggccg ggacggtcga
    18361 gtacatcgtc tcggccgacc gccccgacga gttcttcttc atggagatga acacccggct
    18421 ccaggtcgag caccccgtca ccgagctcgt cacggggctc gacctggtcg agctccagct
    18481 ccgggtggcc gcgggagagc cgctgccgtt cacgcaggac ggggtgcgcc tcgacgggca
    18541 ctccatcgag gcccgcgtct acgccgagga cccggcgcgc ggcttcctgc ccacgggcgg
    18601 acgggtgctc gccctcggcg agcccgaggc cgcgcgggtc gactccgggc tggacgtcgg
    18661 aacggaggtc ggcggctcct acgaccccat gctcgccaag gtcatcgtcc acggcgccga
    18721 ccgcgccgag gcgctgcaca ggctcgaccg cgcgctcgcg tcctacacgc tgctcggcgt
    18781 cccgacgaac gtcgcgttcc tgcgcgccct gctgcggcac ccctcggtcg tgacgggcga
    18841 cctggacacc ggcctggtcg agcgcgccct ggacgagctg gtcgcgggcg cgtccgttcc
    18901 gcccgaggtg ctcgccgccg ccgcgctgga gcggatgctc gacctggagt ccggcgacga
    18961 cccgtgggac gtcccggacg gctggcggcc cggcgcccac gcctgggcgc cgtggatcat
    19021 caccccgtcc ggcggcgacc cggtcgaggt ccgcgtccag ggcagggcgg ggtccgcgcg
    19081 cgtcgccgtc ggcggtgagc cgccggtcgc cgcctcgctc accaggccgt tcacgctgac
    19141 ctacggtgga aggacgacct cgttcgccgg cgcccgggac gggcgcaccc tgtggctcgg
    19201 gcgcgacggg cacgcgtggg cgctgagcga gcacgtccgc gccgagggcg gggccgacgc
    19261 cgccgccgcg ggcgacggcg tgctgcgcag cccgatgccg ggcacggtcc tggcggtcaa
    19321 ggcggccgag ggcgaccgcg tcgaggccgg gcagccgctc gtggtcgtcg aggcgatgaa
    19381 gatggagcac acggtcacgg cgccgctcgc cggcgtcgtg gcgaagctgc cggtccgcgc
    19441 gggcgcgcag gtcgccctgg acgcggtgct ggccgtgatc gaggaggcat gacggtgccg
    19501 gtggttcccc tctccggcct tcccgagcgg gtcacgatct acgaggtcgg gccgcgggac
    19561 gggctgcaga acgagaaggc gatcgtcccc gccgaggtca aggcggagtt cgtgacccgg
    19621 ctggcggacg cggggctgcg cacgatcgag acgaccagct tcgtccaccc caagtgggtg
    19681 ccgcaactgg cggacgccga gcagttgctc gacatcctgc cgcgctcccc caggctgcgg
    19741 taccccgtcc tcgtgccgaa cgagcggggc ctggaccggg cgctcgccaa cggcgtcacc
    19801 gagatcgcga tcttcggcag tgccaccgag accttcgccc gccgcaacct gaaccgcacc
    19861 gtggacgagt ccctcgcgat gttcgccccg gtcgtggaac gggcgcgcgc cgagggcctc
    19921 tgggtgcgcg cctacgtgtc gatggtgtgc ggcgacccgt gggagggcga cgtccccgtg
    19981 gagcaggtcg tgtccgtcgc gtcccgcatg atggacatgg gctgctccca gctcagcctc
    20041 ggcgacacca tcggcgtcgg cacgcccggc caggtcaccg cgctcatcga ggcgctgacc
    20101 gaggcgggcg tcggcaccga ccggctcgcc gtccacttcc acgacaccta cgggcaggcg
    20161 ctggccaaca ccctcgccgc gctccgcgcg ggcgtcaccg tcgtggacgc ctcggcgggc
    20221 ggcctcggcg gctgcccgta cgccgagagc gccaccggca acctgcccac cgaggacctc
    20281 gtctggatgc tgaacggcct cggcgtcgag acgggcgtcg acctcgccgg gctcgtgtcc
    20341 acgagccgct ggatggcggg ccgcctgggc cgtcccagcc cgtcccgcgt agtgcaagcc
    20401 ctgtcacctg aatcggagta accaatgatc gacttcacgc tcggcgagga gcaggaggaa
    20461 ctacggcgca cggtcgagca gttcgcccgc gagaacgtcg ccccggtgat cggggacctg
    20521 tacgagcgcg gcgagttccc ctacgagatc gtcgccgcga tggggaagat ggggctgttc
    20581 gggctcccct tcccggagga gcacggcggc atgggcggcg actacttcac gctctgcctc
    20641 gccctggagg agctggcgcg cgtcgactcg tccgtcgcga tcaccctgga ggccggggtg
    20701 tcgctgggcg cgatgccgat ctaccggttc gggtccgcgg agcagaagga gcggtggctg
    20761 ccgccgctca cctccggcga gcggctggcc ggcttcgggc tgaccgagcc gggcggcggg
    20821 tcggacatcc ccggcggcat gcgcaccacc gcccggctgg acggcgactc ctgggtgatc
    20881 aacgggtcca aggcgttcat caccaactcc ggcaccgaca tcaccgcgtt cgtgaccgtg
    20941 accgcgttca ccggcgacgg cgagatctcc acgatcctcg tcccgaacgg gaccccgggc
    21001 ttcacggtcg ggcgcaagta ctccaaggtc ggctgggcgg cgtccgacac gcgggagctg
    21061 tcgttcgacg acgtccgcgt cccggccgag aacctcgtcg gcgagcgggg ccgggggtac
    21121 gcccagttcc tgcggatcct ggacgagggg cgcatcgcga tcgccgcggt gtcggtcggc
    21181 ctcgcccagg gctgcgtgga cgagtgcctg cgctacgtcc gcgagcggga ggcgttcggc
    21241 aaggagatcg gccgctacca ggcgatccag ttcaaggtcg ccgacatgga gacccgggcg
    21301 cacaccgccc ggctcgccta ctacgcggcg gccgcgagga tgctggcggg cgagccgttc
    21361 aagaaggagg ccgccatcgc caagctggtg gcctccaacg ccgccatgga caacgcccgc
    21421 gacgccacgc aggtcttcgg cggttacggc ttcatgaacg agtacgccgt cggccgattc
    21481 taccgcgacg cgaagatcct ggaagtgggc gagggcacct cggaggtgca gcgcatgctg
    21541 atcgcccgcg ccctcggcct cccgccgtcc tgacgcgcac cgcgcccggc ggcccccgat
    21601 gccgccgggc gcgcctctcc gcgcaacgcc gggttcccgc cggtggcgga gcccggcgcg
    21661 gtaaggtcgg cggatgctgc tgcgcgccta cgggatcgct cgctcactgg tcatgtacca
    21721 cggaattccg ggcaggcacc ggcgcgcgtc gcgcctctac ggagagttcc tcgggcccga
    21781 cgacatcgcg ttcgacatcg gcgcgcacgt gggcggccgg gtgcgggtgt ggcgggggct
    21841 cggagcgcgc gtcgtcgcgg tggagccgca gcccgactgc ctgcgcgtcc tgcgcctgtt
    21901 cttcggccgc gaccgcggcg tcgtcctcgt gccgggcgcc gccggcgccg agcccggacg
    21961 ggcgcacctg gccctgtcca ccgcgacgcc gacggtgtcc tcgatgtcgc ccggctggat
    22021 caaggcggtg acgacggacc gcggcttcgc ccgcgtccgc tgggaccgct cgatcggcgt
    22081 cgacgtgacc acgctggacg agctcatcgc cgtccacggc gtgccggcct tctgcaagat
    22141 cgacgtcgag ggcttcgagg cggacgtgct ggcggggctg tcccggccgc tgcccgccct
    22201 gtcgttcgag tacgtgccgt ccgcgcacga cgcctccctg gaggcgttgg acctcgtgga
    22261 ccggctgggc gactacgtct acaactactc ccccatcgag acgatgcggc tggccagccc
    22321 ccgctggctc gatgcggccg agctgcggcg gcggctggag aggatccgcc cgcgcgggcg
    22381 gtcgggtgac atctacgcgc gtctccgcga atccggcagg ccctgagccg cggtccggct
    22441 cagccggagg acgtcacgaa ggcggcgagc cgggcttcca catcctcacg aggcagctcg
    22501 cgaaggctga cccttgattc cagcgcctcg tgcaggaccg ggtacatgtt cgtcggggac
    22561 cactgggcgt ggatcgatct ctcgtccagg aacagggtgg gaaggccccc gaccacgggg
    22621 accgcttcga agggtgcgga accggggaag aacatcgccg gcgccccgcc ggcgcccggg
    22681 tagtggaacc cgatccgctg gtgctcgatc agctcttgcg cctcctggtg ttcctgcggg
    22741 gtcaggccct ggttccgcgc gtaccgcacg agcgcggggt cggtcggctc ggctccgagg
    22801 tagccggggc ccgcatggcg ttcgagagcg tcctgggcga gcgcgaagaa gtggtacatc
    22861 cggtcctgga cgccggtcag gccgacgacg aagccgcgcc ggccgcgcgg gtcgagcagc
    22921 aggatctccc ggccgtccag aagggcgagc acctcgcgga cgtagtagag ggtctcgtag
    22981 tgctcttcca gttcgtccac cagcggcgct acgtggggcc gggcgcgcag acgccgccgc
    23041 gcgccctcgt cgcggctgag catcgtcatg gccgcaagga ggacgaaggg cagggtgtgg
    23101 tgggcgcgga cgaggtcggg agacacccgg aacagctcgt cctgcgcgct caccccgccc
    23161 tgcaccacga actccttcgc caggcccagg tagcgctcgg tcatctccat gaccgcgtcg
    23221 accgggaccg tcaccgagcc gccccgctcg acgagcaccc cgcacacgaa ggccatcatc
    23281 cccgcgcgga agacgtcgcc ggccccgagc gaggcggcca gttccgccat ggcggcgtcg
    23341 acgtcggtga tggacccgag gaacgcctgc acctcgtccc ggccgatcag gtcggttccg
    23401 gcccggcatt cgcccaggtc actcgactgc cggacgaact gcgcgatccc caccgtctgc
    23461 gacattcgat catgctagcg gcggacgggc cccgagcgcc gcgccttcgg cgaggggccg
    23521 ttctccttcg cgaccgcttc gcggacggcg ggggcgatct cctgccccca gcgggtgacg
    23581 gaggcgaggt cctgcgtccc gccgctgggc gagaagaggg tgaacccgga cgcgccgtgc
    23641 tccaggaccg ctccggtcag ctcctcggcc cactgctcgg gggagcctcc gatccagcgt
    23701 ccgtcgcggt cgcgcgtggc gggcagcggc cggtcggtca cgcgtccggg cagattgaag
    23761 atcgtgcgta tctcgcgcgg gtcgcggccc acagccgcgg cggcctcgtc gatcaccggc
    23821 cgcgacgtcc ggtagcgctc gctgagccag tccgcggcgt ggccggggat ccagccgtcg
    23881 gccacccggc cggtcgcggc gagggacctc gggccgaccg acccggtcca tacgggcggc
    23941 gcggccacgg gagccggctc gatctcctcc acccggtagt ggcggccatg gtgggtgacg
    24001 ggcgggccgc cgccggccag cttcctgacc aggacgatcg cctcttcgaa ggcgtccacc
    24061 gccgcacccg gcgacagccg cggcacgccc atgtcggaga tccgatccca cagcccgccc
    24121 gcgcccatgc cgagcacgac gcggccgccg gagagcgccg acagcgacgt caccgtccgc
    24181 gcgagcatgg gagccggccg ggtcggcagg ttcgtgacgt tggcgaagcc cgcgatgcgc
    24241 tcggtgcggc cgaggacgaa accgatggcg gcgtaggcgt ccaggcgttc accgaggtag
    24301 gggtggtccg acagggagaa gtggtccagg ccgtcacggt cggcctgctg ggccatgcgc
    24361 agcaggccgg ccacgtcctc gacgccggag tgcgcgccga acccgaacag gggcaggccc
    24421 tcgccgccgg ccgcaatcga agtactcatc attccgcgct ccgcactaca gagttacagt
    24481 tcgtatcacg aaccatatta gttcgtagcg cgaactgcaa tccttccggc ggaaggcctc
    24541 agcgcctgcg ggccgcccca tcgtcgggtt cggcgaacac caccgggacc tggttgtcca
    24601 gcacgacgcg gccgagcaga tcggcgaggg cgccgcgctc ggcgtcactg agccccttcg
    24661 gcagccggtc gatccgccgg caggtctcgg cgtagaagtc ctcgacgagc cggctcccct
    24721 cgggggtcag ggcgaccctc accgcgcgca ggtcccgcgg gtcgggctcg cgccggacca
    24781 ggccgttgcg ctcggtgcgg tccaccaggc cggtgaggct cgacttggcc agccccagcg
    24841 tcgcgcccag ttctcccatc cccagcggcc gcgccatcag cacgcacagc aattgcccct
    24901 gctgcgacgt gatgccgtac tcccgcgccg actcgccata aacggcgttc acgagaaacg
    24961 cgcctcgcac cagcgccgcc acgacaccga tccggccctc gtcttctttg cccacgcgac
    25021 cagggtatcc cggcagttcg cgcgacgaac taccgcgccg ccaccccgcg cgccccgtcg
    25081 gcccccacgc gaccgtcaga cgatagcttg acagctaagg ctcttagctt taagttggct
    25141 aacgtcgtta gccaacgttc ggaagggccg tcatcgtgag cgcagccgcc acccggggca
    25201 aggtctccgg catccgcacc gtccgccgcg ccgcgtggtc cgccggcgcg ctcttctgga
    25261 cggccttcgc agtcctcgaa ggcgtcaacc acgggtggct cgcggcgatc ctggcggtcg
    25321 ccttcttcat cgcccccgac ctgaccttcc tcgccgggct gcgggacgcc gccaccaccg
    25381 agcgcggccg gctctcgccg cgcgccgtgc cgtactacaa cgccgcgcac cgggccctgg
    25441 tgccgttcgc gctgatggtg gtctacacgg tcacccctgt gacctgggct ccgctgttcg
    25501 cgggcctgtg cggctggatg gcccacatct ccgtcgaccg cgccttcggc tacggcctcc
    25561 gcaccaagga aggcttccag cgccactgac cccaggcccg ggtcgacgaa gatccggccg
    25621 gcgggttccc cctcccggga gagccggccg accggcaggg ttcatgccgt gcgtcacacc
    25681 gggttcgagg cgctgtcgaa ggaacactcg cgtctgctag aaaatcccgg acccttccag
    25741 gcccgacgac gggtggcaca tggaacccct gcatcccgga gatccccggc ggatcggacc
    25801 gtacgaactg gaggcacggc tgggcgccgg cggcatgggg caggtgttcc tcggggtctc
    25861 gcccggcggc cgcggcgtcg ccgtcaaggt catccgcgcc gagcacgccg aggacgagcg
    25921 gttccggagg cggttcgccc gcgaggtcga ggcggcccgc cgggtgggcg ggttccacac
    25981 cgcgcaggtc gtcgacgccg acccggaggc cgacccgccg tggctggtga ccgcgttcgt
    26041 ccccgggtcg accctccggg aggtggtcgc cgagcacggg ccgctcgatc cggacgcggt
    26101 ccgggcgctc gcggcggggc tggccgaggg cctggccgcg atccacgcgt gcgggctcgt
    26161 gcaccgcgac ctcaagcccg gcaacgtcat catggcggcg gacgggcccc ggatcatcga
    26221 cttcggcatc gccctcgcga ccgacgcgac cgtgctgacc tcgcacaacg tggtcgtcgg
    26281 cacctacgcc tacatgtcgc cggagcaggt gctcggcgag atgcccggcc ctcccggcga
    26341 cgtgttctca ctcggctgcg tgctcgccta cgcggcgacc ggcggcggcc ctttcgacgc
    26401 cacgtccatc ccggcgatcg tccaccgcgt cctgcacgag gagcccgacc tgccggggct
    26461 gcccggcgac ctgagcaaca tgatcgccgc gtgcctggtc aaggatcccg ggcggcggcc
    26521 cgcgctggac gcgctcatca gcgcgccgca gagcatcgaa gcccccgctc ctgcaccggc
    26581 gggcccgtcc ctcccggacg acgacgcggt cggcacgcac gcgaacgcga cgcgcgtcgc
    26641 gacccggcag caggacgccc cggccgtcgc gccggccggc ccggcgcccg tccgccggcg
    26701 ggcgctgctc atcggcgcgg gcgccgtcac ggcggtcgcc gccgcggccg tcccggccgc
    26761 gctgttcctg acgagggggg acggaaggca ggaggcggcg cccccggcgc ccgccccccg
    26821 cccgaagggc ctggtctccc ccagcgggtc gctcaccgcc cccggtgtca agaccctcaa
    26881 cgaggtcgcc atcaccgccg acggccggac cgtcgccgcc gggggcctgg actccacgat
    26941 cacgctgtgg gacgtcgcga ccggacgcgt cctccggacg atcgagaaga cgggatgggt
    27001 gagcgcgctg gcgttcagcc cggacggccg gtccttggcg agttcctgca gcacccccgg
    27061 cctcctgctc gtctgggacg cggccaccgg ccgcctcaag gtgaacgtgc ggagcggcga
    27121 gttcggcctg aactcgctgg actacagccc ggacggccgc acgatcgcgg gcgccaaccc
    27181 cgacgcccgg ctcttcgacg ccgccaccgg ccgcgggctg gcgtcgttcg acctgcgcca
    27241 cagcggcgtc aacgcgatcg cctacagccc ggacggcggg ctcgtcgcgg tcggcgtgga
    27301 cgggtaccac gacaagccgc ccggcaagac cgtccagctc ctcgacggcc ggacgcttcg
    27361 caagcgcggt cagctggtcg gccacacctc gaacctcacc ggcgtggcgt tcagccccga
    27421 cgggaagcgg ctggccagca gcggcgcgga caagaccgtc cgcctctggg acctcgcgtc
    27481 ccggcgcgcc gtgcgcgtca tcaaggcggg cgaggcgacg gtgaaggaca cgaggttctc
    27541 cccggacggc tcgtccgtcc tcgccgcctg ctcggaccgg accatccgga tctggaacgc
    27601 cgccaccggc gtgctcaccg cgacgctcgt cggccactcc cagcccgtcg agcggatcgc
    27661 cctcaccccg gacggccgga ccgtggccgg cgtgggcggc accaaggccg acggcacagt
    27721 gaccctttgg aaggtctgac ccttggatcc gctccgcagt gacgaccccc gccaggtcgg
    27781 cccccaccgg ctggacgggc ggctgggcgc cggcggcatg ggcgaggtgt tcctcggctc
    27841 ctcaccgagc gggcgcaggg tcgcggtgaa ggtcgtccgc gccgagtacg ccgccgatcc
    27901 cgggttccgc aagcggttcg cccgcgagat cgaggccgcc cgcaaggtcg gcgggttcca
    27961 caccgcgcag gtcgtcgatg ccgaccctga ggccgtgtcg ccctggatgg cgaccgcgtt
    28021 cgtgcccggc ccgtccctga ggcaggtggt ggcgcgccag gggccgctcg cgccgcccgc
    28081 ggtccgcgaa ctgggccggg ggctcgccga gggcctggcc gcgatccacg cgtgcgggct
    28141 ggtgcaccgc gacctcaagc ccggcaacgt catcatggcc ccggacggcc cccggatcat
    28201 cgatttcggc atcgcccgcg cgtccgacgc gaccgcgctg acctcgaccg gcgcggtcgt
    28261 cggcacgttc tcgttcatgt cgcccgagca ggtgcgcgcc gacgccaccg gcccggcgag
    28321 cgacgtgttc gcgctcggct gcgtgctcgc ctacgccgcg ctcggccgcg gcccgttcga
    28381 cgcgccgacc atccccgcga tcgtccacaa gatcatcggc tcgccgccga acgtcgccgg
    28441 cctcaccgac cctcccctgc gcgacctgat cgtccgatgc ctggagaagg aacccgcgcg
    28501 gcggccgtcc gtccaggaga tcctgaccgg gctccccacc gaaccgtcgc gccgggtgcc
    28561 ccgccgcgcg ttccttctcg gcggagcggc ggtggcggcg accaccgccg tcgccgtccc
    28621 ggccgtcctg ctgtggccct cggacgtgcc ggccgagcgg aacgtcccga agaccccgat
    28681 cggcgtcccc accggcctcg tcctgccgag ctcggaggtc gcgctcttcg acgtggcgtt
    28741 ctcccccgac ggcaggtccc tgtggggggc gggcttctcc tcgatcctgc gctgggacct
    28801 cgcaactgcc caggtcacca gccgtgagat gaaggacacc gaccagacct accggcggcc
    28861 catggtcttc agcccggacg ccgggaccct cgccaccggc ggcgccgacg gagccgtcca
    28921 cctctgggac gtggcgtccg ggcgcatccg caagaccttc accggagcgc ggggcgtcca
    28981 ggcgctcacg ttcggcccgg acggccggtc gctcgccgtc agcggcggaa acggccccgg
    29041 ccacgtgcag atctgggaca ccgtcaccgg gaagaccgtc cggatgaagg ccgactacta
    29101 cgccaacgcc ctcgccttct cctcggacgg caggacactc gccggcggcc ggtcctactc
    29161 cggacgcttc accctctgga acgtctcgga cggcggcggc accgaggtct ctcccctcaa
    29221 cgccaccgag gttccgtgcc tcgccttcag cccggacgga gaggtcgtcg cggcctccac
    29281 cggcggctac tacggctacg aactccgcaa cgcggacgac ggacggctca agaccagcat
    29341 cagggacctt aagggcgagg tccaggccct cgccttcagc ccggacggcg gcaccctcgt
    29401 caccgccgac aagaagaaca tccgcctgtg gcacgtcccg acgggccgca acacggcgac
    29461 gctcccgggc gacgccgacg aagagcagtc cgtgaccttc tcccccgacg gccagagctt
    29521 cgccaccacc agcggcgccg gcacgaccca cctctggacc ttcgcccccg cctgacatcc
    29581 gggagcgtgc cgtgaccgtc ctcatggctc accgacgggc gctggcaggg ggcggcgccc
    29641 ctggatggcg acccgccgca agccgatcgc ggccgcgatc ccggctaccg tcgccgcccc
    29701 tgccaggaag cgccattggt gcttcgcgcg gcgttctacc cgtgcatagg gcttggtgga
    29761 gaacgagacg agttcgtagc gggacgccca caccccgggc agggccttct gcagcgcgag
    29821 ctcggtcttc cgggtgaacg tgaacaccgg ggaggcgacc ctgtcgcgca tctcgacgaa
    29881 gttgtcaagc gccatccgcg cgatggcgtc ggcgttgtcc ttgcgctgct tctcgtaccg
    29941 cggcagggcg agttcccagg tgccggcggt ctcggtgagg cagcggtcga gttcgacgac
    30001 gtcctcgaag gcgcagttgg cgccctgccc gtagaacggg acgatcgcgt gggcggcgtc
    30061 gccgatcagc gccgtccggc cgcccggcac gtgccatgtg tcgcaccgga cggtgccgag
    30121 cctgcccacg ggattgccga gatagtcctc caccaggccg ggagagagcg gcggcaggtc
    30181 cggatagcgg gcttcgaaat gctccttcac ggcggccggg gtgtcgagcg aggcgaagcc
    30241 cgacgggccc ctgtacggcc agaacagcgt gcaggtgaac gaccggtcgg ggttggggag
    30301 ggcgatcatc atcgcgttcc cgcgcggcca gatgtgcagc gcttcggggt ccagggcgaa
    30361 cgcgccgtcc accgcggaga tggtcagttc cttgtatccg tggtcgagga actcgacgtc
    30421 c
//
