LOCUS       NZ_BMRD01000012        21194 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence12, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000012
VERSION     NZ_BMRD01000012.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 274361)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 117847
            Orig. end                         :: 139041
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21194
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21194
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21194
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11194](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11194
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(1031..1633)
                     /locus_tag="IEZ14_RS26290"
                     /old_locus_tag="GCM10010177_53040"
     CDS             complement(1031..1633)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009691 - cytokinin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lysine_decarbox"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851541.1"
                     /locus_tag="IEZ14_RS26290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53040"
                     /product="TIGR00730 family Rossman fold protein"
                     /protein_id="WP_229810425.1"
                     /sec_met_domain="Lysine_decarbox (E-value: 2.3e-36,
                     bitscore: 118.9, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSRKPLAVCVFCSSSGKIDRRYVDLAAEAGAELARRGHSLVSGG
                     AQVSCMGAVARAARDGGARTVGVIPEGLVSVEISDEDNDELIVTADMRARKGEMDRLSD
                     AFLVLPGGIGTLEELFEVWTARVLAMHDKPVVILDPTGVYEPLRELMKGLTEQGFARPK
                     IWDAVGWTSTVPEAFDLLERTQPRIEFSPEDYAEAEL"
     gene            complement(1679..3337)
                     /locus_tag="IEZ14_RS26295"
                     /old_locus_tag="GCM10010177_53050"
     CDS             complement(1679..3337)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631923.1"
                     /locus_tag="IEZ14_RS26295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53050"
                     /product="ABC transporter permease"
                     /protein_id="WP_229810426.1"
                     /transl_table=11
                     /translation="MSTAIHEARSAAPSRATPLRSLTGTGGLIRLILRRDRFLLPSWVI
                     VLALIPINFVAATDSLYPTAAERLAYGRTTGTNPTFLALYGPLYDTSLGAIIAQRSGFI
                     PVVIALISVLTVVRHTRTEEEAGRRELLGATVTGRGAGLAAALVVTMAADLVLAVLLTA
                     GMTAQGLPFAGSLAFGLQLAAAGCVFAAVAGITAQLSEGAGAARGTAIAALGAAFVVRM
                     AADVGGAGNELSWLGWLSPLGWENRLRAYGGERWWTLALVAVLTAALVAAAGLLSARRD
                     VGAGVLPPKLGPADAPRMLSGSLGLGWRLQSRALYGWLAGFAALGVVYGAVAGGVGDMV
                     KDNPDLEKIFTRLGGQGGITDAYFASIMSMLGLIAAAYTVSATLRLRTEETGQRAEPLL
                     ATPVGRLRWASGHLAFALLGPVAGLGVAGLAAGLAHGLDTGDPGREVPRVLGAALAQLP
                     AVWLVGAIALALFGLAPRLTGGAWAAVGVFAVVTLFGAGLDLNQWALDVSPFTHVPKLP
                     GHDFTATPLLWLLAIAAVLSALGMLGFRRRDLSTA"
     gene            complement(3334..4245)
                     /locus_tag="IEZ14_RS26300"
                     /old_locus_tag="GCM10010177_53060"
     CDS             complement(3334..4245)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631924.1"
                     /locus_tag="IEZ14_RS26300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53060"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_179832956.1"
                     /transl_table=11
                     /translation="MTPNTPPIALSGLVKNFGRTRALDGLDLTVQPGEVHGFLGPNGAG
                     KSTAIRVLLGLLRADGGTARLLGGDPWRDATELHRRLAYVPGDVTLWPNLSGGEVIDLL
                     GRMRGGVNARRKAELLDRFELDPRKKGRAYSKGNRQKVGLIAALASDAELLLLDEPTSG
                     LDPLMEEVFQECVREERRDGRTVLLSSHILSEVEALCDRVTIIRKGVAVESGTLDELRH
                     LTRTSIDAELASAPDGLPLPGAHDVRIDGNKIRFEVDTPELDAALRQLTEVGVRSLSSR
                     PPTLEELFLRHYKDELASEAAR"
     gene            complement(4242..4910)
                     /locus_tag="IEZ14_RS26305"
                     /old_locus_tag="GCM10010177_53070"
     CDS             complement(4242..4910)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653916.1"
                     /locus_tag="IEZ14_RS26305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53070"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_179832955.1"
                     /transl_table=11
                     /translation="MATQERAEDLTGRARIRDAALLEFAEHGVKGATIRGIAKAAGVSP
                     ALVQHHYGTKEALRAACDEHVIEVIRETKQEALRGRMASPNFLAIAMRTALPIQRYLAR
                     ALTDGSAAAAVLFDEAVAFSEEMLERGAPGMSRPHTEDPHGYATVMTGMSFGLIVLHEH
                     MSRALGADVLMGDGYPRMALAMLDVLDDRLLTPELVAQTRAALKTLPAPGGRPPDEEDR
                     "
     misc_feature    4918..4936
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.16"
                     /tool="antismash"
     misc_feature    complement(4919..4937)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.86"
                     /tool="antismash"
     misc_feature    4940..4955
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.05"
                     /tool="antismash"
     misc_feature    4945..4963
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.27"
                     /tool="antismash"
     misc_feature    complement(4949..4967)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    4953..4971
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.01"
                     /tool="antismash"
     misc_feature    complement(4954..4972)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.55"
                     /tool="antismash"
     gene            complement(5038..6120)
                     /locus_tag="IEZ14_RS26310"
                     /old_locus_tag="GCM10010177_53080"
     CDS             complement(5038..6120)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888203.1"
                     /locus_tag="IEZ14_RS26310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53080"
                     /product="S1C family serine protease"
                     /protein_id="WP_229810427.1"
                     /transl_table=11
                     /translation="MDRSARAKACAAALAGAMVLAGCSGKSENAGNAGNAGPASVQTSP
                     PVSGAGSDLQQQYVKVVDAVLPSVVKIQTDQGEGSGVVFDAQGDIVTNAHVVAGAKKIQ
                     VTSSGGGSPLNASMVGAFTADDLAVIKVGGGSLKPASWGESSKAQVGQIVLAMGNPLGL
                     AGSVTNGIVSALHRTVSTKGEGDFQGSTIADAIQTSADINPGNSGGALVTLDGQVIGIP
                     TAAASDPQIGAAAPGIGFATPSDTVKRIVPQLIESGKVSNSGRAALGVAVRTIVDPQTG
                     RRSAVAVVEVQKGGGAAKAGIQKGDLILSVNGTATPDQTVLTTVLTDLRPGETVKVEIQ
                     KPDGSKKQVQVTLGELPGGG"
     gene            6300..6725
                     /locus_tag="IEZ14_RS26315"
                     /old_locus_tag="GCM10010177_53090"
     CDS             6300..6725
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017597290.1"
                     /locus_tag="IEZ14_RS26315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53090"
                     /product="archease"
                     /protein_id="WP_179832953.1"
                     /transl_table=11
                     /translation="MSRASGHRDVPHAADLRIEAWAPTRERCVAEAVAGLVESFADVSG
                     VRPSGDILRVDVPPGPDADLLVAVLDEVVYRLDADGALVLDAEITGAPDGGLTVRLATG
                     DAAEAVGTGAVPKAVSLHELRFGRDARGWSCAVTIDV"
     gene            complement(6766..8184)
                     /locus_tag="IEZ14_RS26320"
                     /old_locus_tag="GCM10010177_53100"
     CDS             complement(6766..8184)
                     /EC_number="6.5.1.8"
                     /GO_function="GO:0008452 - RNA ligase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131092.1"
                     /locus_tag="IEZ14_RS26320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53100"
                     /product="RtcB family protein"
                     /protein_id="WP_276530295.1"
                     /transl_table=11
                     /translation="MHADLVEDGPYRFRIEPTGAMRVPGVLFASRELLAPAENAIEQVA
                     HVAALPGVVEASYAMPDVHLGYGFPIGGVAATDPREGGVVSPGGVGFDISCGVRLLAAD
                     TDASGLAPALRDLMDGLDPVIPRGMGKGAVWHLPGRRDLTGILTGGARYAVEQGHGNER
                     DLRRCEDAGAVADADPGQVSERAVERGARQVGSLGSGNHFLEVQRVAEVYDADAAGAFG
                     LRPGQVCVMIHCGSRGLGHQICTDHVRAMEAAMPRHGIEVPDRQLACAPVDSAEGRAYL
                     GAMAAAANYGRANRQLLTEAARRVFRRVAGARLDLVYDVSHNLAKLEEHVVDGEPRRLC
                     VHRKGATRALPPGHPDLPPDLREAGQPVLIPGTMGTSSYVLTGVPGAPAFSSTCHGAGR
                     VQSRHQAARGVGGRQLRAALEEQGIAVRPSSWRGLAEEAPDAYKDVSAVVEAAEGAGLC
                     RKVARLVPLGVVKG"
     gene            8288..8941
                     /locus_tag="IEZ14_RS26325"
                     /old_locus_tag="GCM10010177_53110"
     CDS             8288..8941
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF046230.1"
                     /locus_tag="IEZ14_RS26325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53110"
                     /product="hypothetical protein"
                     /protein_id="WP_179832951.1"
                     /transl_table=11
                     /translation="MLAEPAPSLSDLALGLVVVVLALRLGRAPAPHRHWRTAFWWVGIA
                     ALAGSVHHGLITYSERWSGPSWAVISGMVVVAVSYLLAATVAEVLGPHHGRTFWLLRSI
                     GIVAYAVLAVTGHAGVGALLACESLTMVCILALWGWAAWHRHPMAGPVIVALVASAAAA
                     ATKAIDPSVTRRVALDPTSVYHLAQIVGMVLLYLAVTKPRRPDRPDREPRALLR"
     gene            9114..9950
                     /locus_tag="IEZ14_RS26330"
                     /old_locus_tag="GCM10010177_53120"
     CDS             9114..9950
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570447.1"
                     /locus_tag="IEZ14_RS26330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53120"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_179832950.1"
                     /transl_table=11
                     /translation="MTAIASVYQHDVATYWNTERNPVNLRLGDVSGIYHHHYGIGEVDW
                     SVLETPEDAREEAIITELHRLENAQARFLLEHLGDVRPDHRLMDAGSGRGGSSIMANAA
                     FGCRVDGVSISQAQVDFANGQAAQRGVSDKVRFHFKNMLDTGFEAGAFQAIWNNESTMY
                     TVLDDLFAAHSRLLARGGRYVTITGCYNDVYGLPSRAVSTINAHYVCDIHPRSAYFRAM
                     AANRLVPVTVVDLTADTIPYWELREKSSVATGIESAFLEAYRDGSFQYLLIAADRI"
     gene            10001..11194
                     /locus_tag="IEZ14_RS26335"
                     /old_locus_tag="GCM10010177_53130"
     CDS             10001..11194
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041167.1"
                     /locus_tag="IEZ14_RS26335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53130"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_218935003.1"
                     /sec_met_domain="T1TS (E-value: 1.1e-55, bitscore: 183.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METTHHGCSGRRAPYGSSAEPRPERPSGVGTEAVSLPSLIAAARP
                     SREPSYGDLLAGRHPRPVGGGGPGYVERAWGDGSHSPLYCPLPERADDALAAEVDARLA
                     SWARDRGFDDHELDALGKAAFGRLVTLAHPDTDDPDALLVAAQMNAGWWAADDYYADDT
                     ALGALPAMLPQRLTLVMSAMDPVPPAGEFTPPLSEALQGDVVLRMLGSAVDHLKRHASP
                     VQVQRICYSTFAMFVSWTAYAAWREKGEHPPAWEYLAARQHDSFYTSMTLIDVLGGYEV
                     PAQLYYDPRVRRAAFRAGTASVIVNDLHSVAKDAADENPVCNLVLLIAADEGCSVEEAT
                     ETAVRLHNDLVRDFEAGHRELAGVPSPELQRFLRGLRAWMGGGFEWHATNPRYREGA"
     gene            complement(11277..11522)
                     /locus_tag="IEZ14_RS26340"
                     /old_locus_tag="GCM10010177_53140"
     CDS             complement(11277..11522)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="IEZ14_RS26340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53140"
                     /product="cytochrome P450"
                     /protein_id="WP_179832949.1"
                     /sec_met_domain="p450 (E-value: 2.2e-07, bitscore: 23.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFAEPDRFDLGRDTTAKISFGSGRHYCIGAHLARLEARVALEELA
                     ARTGGYDIDEAGARRVNSPYARGFAELPTTITRGAG"
     gene            11536..11745
                     /locus_tag="IEZ14_RS26345"
                     /old_locus_tag="GCM10010177_53150"
     CDS             11536..11745
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013989.5"
                     /locus_tag="IEZ14_RS26345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53150"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_229810428.1"
                     /transl_table=11
                     /translation="MAAQALLRAGELDELELHVVPVLLGQGRRLFDHLPPDHHELRLIR
                     QLATPETGDPAQAVLHLRYRVLRP"
     gene            11841..12188
                     /locus_tag="IEZ14_RS26350"
                     /old_locus_tag="GCM10010177_53160"
     CDS             11841..12188
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS26350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_53160"
                     /product="hypothetical protein"
                     /protein_id="WP_179832948.1"
                     /transl_table=11
                     /translation="MTTENTVAGPRKRSGWRVAAASTLALLLPVTVLAWIAVLATPEYG
                     RCLTYGEQCDPASDVLLPIAWWCFWGSGAAGVIALLLRSPWTVTSRIRPVLVIGQVALA
                     IVTPTAVIVSG"
     misc_feature    12200..12215
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            12261..12890
                     /locus_tag="IEZ14_RS26355"
                     /old_locus_tag="GCM10010177_53170"
     CDS             12261..12890
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017595504.1"
                     /locus_tag="IEZ14_RS26355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53170"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_179832947.1"
                     /transl_table=11
                     /translation="MRARVHSGDPDAFRELFDEHVRSVYNHAFRLTGNWSTAEDVVSLT
                     FLESWRLRERVDVEVEGSLRPWLLGIATNVARNVRRAARRHDGALARLPRNDVVPDFTD
                     EVTSRIDDRERLALMRTALAALRKPEREVLALCVWSGLGYAEAAEALGVPVGTVRSRLS
                     RARKKLERLATASAGPPGERREPLPGHGQEEDDRAIAVRSAQERTR"
     gene            12887..13858
                     /locus_tag="IEZ14_RS26360"
                     /old_locus_tag="GCM10010177_53180"
     CDS             12887..13858
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038083.1"
                     /locus_tag="IEZ14_RS26360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53180"
                     /product="CU044_5270 family protein"
                     /protein_id="WP_179832946.1"
                     /transl_table=11
                     /translation="MNPTPTQPNSNEHEELARLLPAPVERDLPGDRQQRLREFVMSEID
                     QDLRPAEQASRRSARRRPVILASAGIAAATAAAAVVVGIAGTGGAEGAKESPSASATGS
                     PSGRQVLLVAATTALKAPAGSGTYWHVKTIYTDRDGGARTTMESWTRRDGRVWWKGGKT
                     QGRVVMLTRPAPFRLGGPAVTLAQLQGLPTTPGGLKAWIVAAVKKSDVTTSAGRPDAAA
                     QERLVFEGLLSLLSQLPAPPQVRAAAFRAVASYPDVEDLGPVKGGQGLSISFGGGRKAN
                     LVIDPKTSRITDTDYFVSADGAQVTAPGGAEIVAEWTSVAPG"
     gene            complement(13927..14727)
                     /locus_tag="IEZ14_RS26365"
                     /old_locus_tag="GCM10010177_53190"
     CDS             complement(13927..14727)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009691 - cytokinin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lysine_decarbox"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629765.1"
                     /locus_tag="IEZ14_RS26365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53190"
                     /product="TIGR00730 family Rossman fold protein"
                     /protein_id="WP_179832945.1"
                     /sec_met_domain="Lysine_decarbox (E-value: 1.8e-35,
                     bitscore: 116.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEVNSRSRRQGPAMLRGRAVPPTTTDQRLLDGRGPVDWVHADP
                     WRVLRIQAEFVEGFGLLAELPKAVSVFGSARTKPDSPEYELAVDIGARLHEAGYAVITG
                     GGPGIMEAANKGCDENGGLSVGLGIELPFEQKLNDHLDIGLEFRYFFVRKTMFVKYSQA
                     FVVLPGGFGTLDELFEAITLVQTKKITRFPIVLVGTRFWGGLLDWVKESMLTSGKISPQ
                     DIDLFHLTDDPEEVVKIIIEGHTRAQQEIIESRAAVEAADSAGE"
     gene            complement(14724..15800)
                     /gene="dapE"
                     /locus_tag="IEZ14_RS26370"
                     /old_locus_tag="GCM10010177_53200"
     CDS             complement(14724..15800)
                     /EC_number="3.5.1.18"
                     /GO_function="GO:0009014 - succinyl-diaminopimelate
                     desuccinylase activity [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="dapE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017627511.1"
                     /locus_tag="IEZ14_RS26370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53200"
                     /product="succinyl-diaminopimelate desuccinylase"
                     /protein_id="WP_179832944.1"
                     /transl_table=11
                     /translation="MGLDLYSDVAGLTAAVVDIESVSGGEESLAGAVEEALRTLPHLAV
                     ERVGNNVVARTDLGRAERVVLAGHLDTVPLNGNLPSRVEGDRLYGCGTTDMKSGVAVAL
                     RLAATVEAPSRDVTYVFYDCEEVEAARNGLRHLAESRPELLAGDFAVLMEPTGGLIEGG
                     CQGTMRVQITATGERAHSARAWMGSNAIHSAGAILDVLRAYEPSRPVVDGLEYHEGLNA
                     VFISGGVAGNVIPDECVVTVNYRFAPDKSLADAEAYLREIFAGFQVTVTDGAPAARPGL
                     NHPAAAAFAAMSGAEVRAKLGWTDVARFAELGVPAVNYGPGEPTLAHTRDEYVEIPLIA
                     ECEQRMRTWLEGPITVAS"
     gene            15834..16517
                     /locus_tag="IEZ14_RS26375"
                     /old_locus_tag="GCM10010177_53210"
     CDS             15834..16517
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013786.5"
                     /locus_tag="IEZ14_RS26375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53210"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_229810446.1"
                     /transl_table=11
                     /translation="MPVLECAVHWARPADDPRMRDLLDDGERDRYARFMRAEDKARFVT
                     GRFLARTVLAEATGRPPHDLHFTTGCPHCGDAHGKPRLPGSGLDFSLSHSGDRVLLVLV
                     EGAEVGADVEQESDRDVDSLSRMVLTAAEAEVLRTMADRKRGFHAYWSRKEALLKATGH
                     GLAAPMTAIHVSGPDEPPEVVAWEGEAAVSPVRLADLDAGPGYAASAAVLTDRPLRLAE
                     FPLRC"
     gene            complement(16507..17343)
                     /locus_tag="IEZ14_RS26380"
                     /old_locus_tag="GCM10010177_53220"
     CDS             complement(16507..17343)
                     /EC_number="2.3.1.117"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018655690.1"
                     /locus_tag="IEZ14_RS26380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53220"
                     /product="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
                     N-succinyltransferase"
                     /protein_id="WP_179832942.1"
                     /transl_table=11
                     /translation="MTETFTSPISGDIDELWERRAELTPDDAGARAAIVAAVDQLDSGE
                     ARVARIDPATDEVVVDERAKRAILLSFKVLGMARSQVGDFRYHDRIPLKTRLDGVRVVP
                     GAIARWGAHLAPGVVLMPSFTNIGAYVDSGTMVDTWATVGSCAQVGKNVHLSGGVGIGG
                     VLEPPNAKPVVIEDEAMIGSRSMIVEGARVGRGAVVGSGTNLSASMPVIDVETGEEISR
                     GRIPDWCVAVGGTRYKEFKGGTFGLPAVLILKRLEEGQRHDKASLNDILRDHGINT"
     gene            17388..18305
                     /locus_tag="IEZ14_RS26385"
                     /old_locus_tag="GCM10010177_53230"
     CDS             17388..18305
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851537.1"
                     /locus_tag="IEZ14_RS26385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53230"
                     /product="hypothetical protein"
                     /protein_id="WP_229810430.1"
                     /transl_table=11
                     /translation="MAVWARLKARPEEGASGGRRRRGVRWAAVLCVVVLLVGVGVYVAF
                     QRARPYLHGSGCEVRTSLGKMPLDLEQGANAATVAAVAFRKQLPERAVVIAYATAIQES
                     HIHNLPNGDRDSVGMFQQRPSQGWGTPDKLRDPVQATSKFFDALVKVKDYLDRDLHDAA
                     QKVQRSADGRAYAQHEPDGKLLATAFTGREPATARCWYPPDKKTTSRRPEALLEMRRAF
                     GSRLKVGGPGPLKAGSPSDPKSWNAVQVTNPRSGWAVASWAVTHAQAYGLTEVRYAGKH
                     WKSNAGHDGWTADEQAAQTTVIVQ"
     gene            18316..18975
                     /locus_tag="IEZ14_RS26390"
                     /old_locus_tag="GCM10010177_53240"
     CDS             18316..18975
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024354.5"
                     /locus_tag="IEZ14_RS26390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53240"
                     /product="DUF3841 domain-containing protein"
                     /protein_id="WP_179832941.1"
                     /transl_table=11
                     /translation="MPPFPVRDAEPEQAVPAGRMGYDLDAERLLLHTVQSAEAFEALLT
                     TGTLTTDPDLAEAEFTDAYDWIHRMMAARLPTSGEGALWLWARTRREHLVDSCRRSRGQ
                     VLLTCRVPRERVLLSHFDEWHLVLNRALGMPRLPGESEDDAFARWEEAQDVFDARLRAA
                     GLRDAPIRNWTPDLRNEIETSWECILDRANYGPSECWQATVHALNTNDVVEATRIT"
     misc_feature    19017..19031
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.43"
                     /tool="antismash"
     gene            19039..>19226
                     /locus_tag="IEZ14_RS41835"
     CDS             19039..>19226
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS41835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_229810431.1"
                     /transl_table=11
                     /translation="MYNFAMDAVDLQKLLDKVFKQAVVYHGFVDYMRDYEVIVRPSGDP
                     VTGVRPAHLRYLFRYCV"
     misc_feature    19084..19095
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.18"
                     /tool="antismash"
     assembly_gap    19227..19249
                     /estimated_length=23
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <19250..19568
                     /locus_tag="IEZ14_RS41840"
                     /old_locus_tag="GCM10010177_53260"
     CDS             <19252..19568
                     /codon_start=2
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS41840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_53260"
                     /product="hypothetical protein"
                     /protein_id="WP_229810432.1"
                     /transl_table=11
                     /translation="ARCQTTLSADAWTESLDDRLTDYRSGVDIYGYLWGVKWHVLYPGA
                     SVVAESKSADKWTAALGIDFHEVRIETNAHDLTLVFSDLQTSEVPAGHAPFTVGEGPAR
                     P"
     misc_feature    19661..19677
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.43"
                     /tool="antismash"
     gene            19814..20989
                     /locus_tag="IEZ14_RS26400"
                     /old_locus_tag="GCM10010177_53270"
     CDS             19814..20989
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF045194.2"
                     /locus_tag="IEZ14_RS26400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_53270"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_218935000.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2e-38, bitscore:
                     125.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIPRTLVLTGHFPPEPGGVQTFTWELVRRLPADRLVVVAPAWPG
                     AAEFDADLGFPVVRRHAYLLFRGLRRLVVRHRVEAGWITAAAPFGMYAPLVRAAGVRWL
                     VGSAHGQELGWFRAPPTRLALRTAARSFDVLTHLSATTLPELTDAVGDRTRLARLAGAV
                     DTVRFRPGLDGTAVRRRHGLGDGPVVLSVARLVRRKGHDMLIRAWADVVRRRPDARLVI
                     VGDGPMRRRLTEMADREAPGTVTVTGPVSAAELPRYYAAADVFSLPCRDDRAGLQTEGL
                     GLSVLEASAAGLPVVVGRSGGSPESLIDGRTGVLVDATGPDEIALALHRLLGSPARAAA
                     MGAAGRRWTCERWSWDAAAARLAALLKGSVLDAPPKHDTPGMEPAWDSGSS"
ORIGIN
        1 gatgatgaac tgcgacgtgc tgttcatgat cggcacgagc tttccgtacg ccgagtggct
       61 gccggacgag ggcagctgca ggggcgtgga gatcgacatc gacgggcgca tgatcggcat
      121 tcgctacccg atggacgcgc acgtcgtcgg ggacgccgcc gagacgctcc gagagctgat
      181 cccgctgctg cgccgcaagg aggaccgctc ctggcgcgag gagatcgagg agaacgtccg
      241 cacctgggac acggtcatgg agaagcgggc cggccagagc ttcgagggca agatcaaccc
      301 gcaggccgtc gcgcacgagt tgtccccgct gctgccggac gatgtgatcc tcaccgccga
      361 ctccggctcg gccaccaact ggtgggcccg gcacctcaag ctccgcgacg ggatgcgggc
      421 gtcactgtcg ggcaccctcg ccacgatggg ccccggcgtc ccgtacgcca tcgcggcccg
      481 gttcgcctac cccgaccgcc cggtgatctg cttcgtcggc gacggcgcgt tccagatgaa
      541 cggcatgaac gagatgctca ccgtgaagcg gtacgccgag cggatggccg gctcgccgct
      601 ggtcttcgcg gtgttcaaca accaggacct caaccaggtc acctgggagc agcgcgcgat
      661 gggcggcgac ccgaagtacg agggctcgca gagcatcccg gacttcccct actccgagtt
      721 cgccgaactc tgcggtctca agggcatcta ctgcgacgat cccgcgaagg tcaccgaggc
      781 ctggcgggag gccctggcga gcgaccgtcc cgtcgtgctg gagttcgtgg tcgacagcga
      841 gatcgccccg atcccgccgc acatcatgaa ggaccaggcg aggaaggccg tcaaggcggg
      901 cctcaaggac ccgcagaggc tcggtatcgc ggcccgcggc ttccgccaga agctgaccga
      961 catgtacgag aacattccgg gccgcagaca tgactgaccg gcgtccggag cggagtggtt
     1021 cgcccgtcgg tcagagttcg gcttcggcgt agtcctcggg ggagaactcg atgcggggct
     1081 gtgtccgctc caggaggtcg aacgcctcgg ggacggtgct cgtccagccg acggcgtccc
     1141 agatcttggg gcgggcgaag ccctgctcgg tgaggccctt catcagctcg cgcagcggct
     1201 cgtagacgcc ggtcgggtcg aggatgacga cgggcttgtc gtgcatggcg aggacgcggg
     1261 ccgtccacac ctcgaacagc tcctccagcg tgccgatgcc gccgggcagg acgaggaacg
     1321 cgtcgctgag ccggtccatc tcgcccttgc gggcccgcat gtcggcggtg acgatcagct
     1381 cgtcgttgtc ctcgtcggag atctcgacgc tgaccagccc ctcggggatc acgccgaccg
     1441 tgcgggcgcc gccgtcccgc gcggcgcggg cgacggcgcc catgcacgag acctgggcgc
     1501 cgccgctgac gaggctgtgg ccgcgccggg ccagctcggc gccggcctcg gcggcgaggt
     1561 cgacgtaccg gcggtcgatc ttgccactgg acgagcagaa cacgcacacg gcgaggggtt
     1621 tccgggagtt cacccggccc aatctaacgg gtccgtccgg gtggggccgg aggagggctc
     1681 acgccgtgga gaggtcccgg cgacggaaac cgagcatgcc gagggcggac aggacggccg
     1741 cgatcgcgag cagccagagc agcggcgtgg ccgtgaagtc gtgccccggc agcttcggaa
     1801 cgtgggtgaa cggtgagacg tccagggccc actggttcag gtcgagcccg gctccgaaga
     1861 gcgtcacgac cgcgaagacg ccgaccgcgg cccaggcgcc gccggtgagc ctaggcgcga
     1921 ggccgaacag cgcgagcgcg atcgccccga ccagccacac ggcgggcagc tgcgcgagcg
     1981 cggcgccgag gacgcgcggc acctcgcggc cggggtcgcc ggtgtccagg ccgtgcgcga
     2041 gcccggcggc caggcccgcg acgccgaggc cggcgaccgg gccgagcagc gcgaaggcca
     2101 ggtggccgga cgcccaccgc agccgcccga cgggggtggc gagcagcggc tcggcgcgct
     2161 gcccggtctc ctcggtgcgc agccgcagcg tggccgagac cgtgtaggcg gcggcgatca
     2221 ggccgagcat gctcatgatc gaggcgaagt aggcgtcggt gatcccgccc tgcccgccga
     2281 gccgggtgaa gatcttctcc aggtcggggt tgtccttgac catgtcgccg acgccgcccg
     2341 ccaccgcgcc gtacacgacg ccgagcgcgg cgaacccggc gagccagccg tagagggccc
     2401 ggctctggag ccgccagccg aggccgaggg accccgagag catgcgcggg gcgtccgcgg
     2461 ggccgagctt gggcggcagc acgcccgcgc ccacgtcccg gcgcgccgac agcaggcccg
     2521 cggcggcgac cagggcggcc gtcagcacgg cgaccagcgc gagcgtccac cagcgttcgc
     2581 cgccgtaggc gcgcaggcgg ttctcccagc cgagcgggga cagccagccc agccacgaca
     2641 gctcgttgcc cgcgccgccg acgtcggcgg ccatccggac cacgaacgcg gcgccgagcg
     2701 cggcgatcgc cgtgcccctg gcggcgcccg caccctcgct gagctgggcg gtgatgcccg
     2761 cgacggcggc gaagacgcat ccggcggcgg ccagttgcag gccgaacgcc agcgagcccg
     2821 cgaacggcag gccctgcgcg gtcatgcccg cggtcagcag gacggccagg acgaggtcgg
     2881 ccgccatcgt cacgacgagc gcggcggcca ggcccgcccc gcgcccggtg acggtggcgc
     2941 cgagcagctc gcggcggccc gcctcctcct cggtccgggt gtgccggacg acggtgagca
     3001 cgctgatcag cgcgatgacc accgggatga acccggagcg ctgggcgatg atcgcgccga
     3061 ggctcgtgtc gtacagcggc ccgtacaggg cgaggaacgt cgggttggtc cccgtcgtcc
     3121 gcccgtacgc gagccgctcg gcggcggtcg ggtagaggct gtcggtggcc gccacgaagt
     3181 tgatcgggat cagcgccagc acgatcaccc aggacggcag caggaaccgg tcgcggcgca
     3241 ggatcagcct gatcagcccg ccggtcccgg tgagcgaccg cagcggcgtc gcccgggacg
     3301 gcgcggccga ccgcgcctcg tggatcgccg tgctcatcgg gccgcctccg atgcgagctc
     3361 gtccttgtag tggcgcagga acagctcctc cagcgtcggc gggcggctgc tcaggctccg
     3421 cacgccgacc tcggtgagct gccgcagcgc cgcgtccagt tcgggggtgt ccacctcgaa
     3481 gcggatcttg ttgccgtcga tgcggacgtc gtgcgcgccg ggcagcggca gcccgtccgg
     3541 cgccgacgcc agctccgcgt cgatggacgt gcgggtcagg tgccgcagct cgtccagcgt
     3601 ccccgactcc accgcgacgc ccttgcggat gatcgtcacc cggtcgcaga gcgcctcgac
     3661 ctcggacagg atgtggctgg acagcagcac ggtccggccg tcgcgccgct cctcccggac
     3721 gcactcctgg aacacctcct ccatgagggg gtccaggccg gaggtgggct cgtcgagcag
     3781 cagcagctcg gcgtcggacg ccagcgcggc gatgagcccg accttctgcc ggttgccctt
     3841 ggagtaggcg cggcccttct tgcgcgggtc gagctcgaac cggtcgagca gttcggcctt
     3901 gcggcgcgcg ttcacgccgc cgcgcatccg gccgagcagg tcgatcacct cgccgccgga
     3961 caggttcggc cacagcgtga cgtcgccggg gacgtaggcg agccggcggt gcagctcggt
     4021 cgcgtcccgc cacgggtcgc cgccgagcag ccgggcggtg cccccgtcgg cgcgcagcag
     4081 gccgagcagg acgcggatgg cggtcgactt cccggcgccg ttcgggccga ggaagccgtg
     4141 cacctcgccg ggctggacgg tcaggtccag gccgtccagc gcgcgggtcc ggccgaagtt
     4201 cttgaccagg ccggagaggg ctatgggggg cgtgttcggg gtcaccggtc ctcctcgtcg
     4261 gggggtcgcc cgccgggggc gggcagggtc ttgagggcgg cgcgcgtctg cgccaccagt
     4321 tcgggcgtca ggagccggtc gtcgaggacg tccagcatcg ccagcgccat gcgggggtag
     4381 ccgtcgccca tcaggacgtc ggcgccgagc gcgcgcgaca tgtgctcgtg caggacgatc
     4441 aggccgaagc tcatgccggt catgaccgtc gcgtagccgt gcgggtcctc ggtgtgcggc
     4501 cgggacatgc cgggcgcgcc ccgttcgagc atctcctcgc tgaacgcgac cgcctcgtcg
     4561 aagagcacgg ccgcggcggc cgacccgtcg gtcagggcgc gggccaggta gcgctggatc
     4621 ggcagggccg tccgcatggc gatcgcgagg aagttcgggc tcgccatcct gccgcgcagg
     4681 gcctcctgct tggtctcgcg gatcacctcg atcacgtgct cgtcgcaggc cgcgcgcagc
     4741 gcctccttcg tcccgtagtg gtgctggacg agggcgggcg acacgcccgc ggccttcgcg
     4801 atgccccgga tcgtggcgcc cttcaccccg tgctcggcga actccagcag ggccgcgtcc
     4861 ctgatccggg cgcgcccggt caggtcctcg gcccgctcct gcgtcgccat tcccaccccc
     4921 tgtacgaatg ttcagttgcc tgtacgcttg tacactgtac tcacgtacag gcttccgtca
     4981 accgtggggg cctgcggccc gggccgggcg gtggggccgg acggtggtcc gggcgggtca
     5041 accgcctccg ggcagctcgc cgagcgtcac ctggacctgc ttcttcgagc cgtccggctt
     5101 ctggatctcg accttcaccg tttcgccggg cctgaggtcc gtgaggacgg tcgtcagcac
     5161 cgtctggtcg ggcgtcgcgg tgccgttcac cgagaggatc aggtcgccct tctggatccc
     5221 ggccttggcg gccccgccgc ccttctgcac ctccacgacg gcgaccgccg accgccggcc
     5281 ggtctgcggg tcgacgatcg tgcgcaccgc cacgccgagc gcggcccggc cggagttcga
     5341 caccttcccc gactcgatga gctgcgggac gatccgtttg accgtgtcgc tcggcgtcgc
     5401 gaacccgatg ccgggcgccg cggcgccgat ctgcgggtcg gaggccgccg cggtggggat
     5461 gccgatcacc tgcccgtcca gcgtgaccag ggcgccgccg ctgttgcccg ggttgatgtc
     5521 cgcgctcgtc tggatggcgt cggcgatcgt cgagccctgg aagtccccct cgcccttggt
     5581 cgacaccgtg cggtgcagcg cggagacgat cccgttcgtc acgcttccgg cgaggccgag
     5641 cgggttgccc atcgccagaa cgatctgccc gacctgcgcc ttgctcgact cgccccacga
     5701 ggccggtttc agcgacccgc cgccgacctt gatgacggcc aggtcgtcgg cggtgaacgc
     5761 gccgaccatc gaggcgttca gcggggagcc gccgccggac gaggtgacct ggatcttctt
     5821 cgcccccgcg accacgtgcg cgttggtgac gatgtcgccc tgggcgtcga acacgacgcc
     5881 cgacccctcg ccctggtcgg tctggatctt caccaccgac ggcaggacgg cgtccacgac
     5941 cttcacgtac tgctgctgca ggtccgaccc ggccccggac accgggggcg acgtctgcac
     6001 cgacgccggc ccggcgttcc cggcgttccc cgcgttctcg gacttcccac tgcacccggc
     6061 gagcaccatc gcccccgcca gcgccgccgc gcatgccttc gccctcgcgc tcctgtccac
     6121 gctccacctc cagaggggac ggttcccgcc cgccgagcga cgggcgccgc gccacgcgcg
     6181 attttgcgac gtcatgccgc aggtcagagc cgcagctgat ctttggaggc gcccggtgcg
     6241 cgcccggccg cgcggggccc ggccggtttc tcatgatcgg agccgggtag ccgtccgaca
     6301 tgtcgcgcgc aagcgggcac cgggacgtcc cccacgccgc cgacctgagg atcgaggcgt
     6361 gggccccgac gcgggaacgc tgcgtcgccg aggcggtggc cgggctcgtg gagtcgttcg
     6421 ccgacgtctc cggcgtccgc ccgtccggcg acatcctccg ggtggacgtg ccgccgggcc
     6481 cggacgcgga cctgctcgtc gccgtcctgg acgaggtcgt ctaccgcctg gacgccgacg
     6541 gcgccctggt cctggacgcc gagatcacgg gggcgccgga cggcgggctc accgtccggc
     6601 tcgcgaccgg ggacgcggcg gaggcggtgg ggacgggagc cgtgcccaag gcggtgtcgc
     6661 tgcacgaact gcggttcggc cgcgacgccc gcggctggtc ctgcgcggtg acgatcgacg
     6721 tgtgaccggc ggcgcaccgg gcggaaggcg tgggcgaccg gccggtcagc ccttcacgac
     6781 gcccagcggg acgaggcggg cgaccttccg gcagagtccc gcgccctcgg cggcctcgac
     6841 cacggcggac acgtccttgt aggcgtccgg cgcctcctcg gccaggccgc gccacgacga
     6901 cggccgcacg gcgatgccct gctcctccag cgccgcccgc aactgcctgc cgccgacgcc
     6961 gcgtgcggcc tggtggcggc tctgcacccg tccggcgccg tggcacgtgg acgagaacgc
     7021 cggcgcgccc ggcacgcccg tcaggacgta ggacgaggtc cccatcgtcc cggggatcag
     7081 cacgggctgc ccggcctcgc gcaggtcggg cggcagatcg ggatggccgg gcggcagggc
     7141 gcgggtggcc cccttgcggt gcacgcacag ccgccgcggc tcgccgtcca ccacgtgctc
     7201 ttcgagcttg gccaggttgt gcgagacgtc gtagacgagg tcgagccggg cgcccgcgac
     7261 ccggcggaac acccggcgcg ccgcctcggt gagcagctgg cggttggcgc ggccgtagtt
     7321 ggccgccgcc gccatcgcgc ccaggtaggc gcggccctcg gcggagtcga ccggggcgca
     7381 ggcgagctgc cggtcgggga cctcgatgcc gtgccgcggc atcgccgcct ccatcgcccg
     7441 gacgtggtcg gtgcagatct ggtggccgag cccgcgcgac ccgcagtgga tcatgacgca
     7501 gacctggccc ggccgcagcc cgaacgcccc ggccgcgtcc gcgtcgtaga cctcggcgac
     7561 ccgctgcacc tccaggaagt ggttgcccga gccgaggctg ccgacctgcc gggcgccgcg
     7621 ctccaccgcg cgctcgctca cctggccggg gtcggcgtcg gcgaccgctc ccgcgtcctc
     7681 gcagcggcgc aggtcgcgct cgttcccgtg gccctgctcg accgcgtacc gcgctccccc
     7741 cgtgaggatg ccggtcaggt cccgccgtcc cggcagatgc cacaccgcgc ccttgcccat
     7801 gccgcgcggg atgacggggt cgaggccgtc catcaggtcc cgcagggcgg gggcgaggcc
     7861 ggaggcgtcg gtgtccgccg ccagcagccg gacgccgcac gagatgtcga atccgacgcc
     7921 gccgggcgag accacgccgc cctcgcgcgg atcggtcgcc gccacgccgc cgatcgggaa
     7981 gccgtatccc aggtggacgt cgggcatggc gtacgaggcc tccaccactc ccgggagcgc
     8041 ggcgacgtgg gcgacctgct cgatcgcgtt ctcggcgggc gccagcagct cccgcgacgc
     8101 gaacagcacg ccgggcacgc gcatggcgcc ggtcggctcg atccggaacc ggtaggggcc
     8161 gtcctcgacc aggtcggcgt gcacaaggcg ggggttaccc ccggccccgc cccccatgcg
     8221 tcctcatgcg ccccggtgcg tcgggggccg gggggttcac gggcatcatg cgggtagcgt
     8281 gcgaatcatg ctggccgaac ccgcgccctc gctgagcgac ctcgcgctcg ggctggtcgt
     8341 ggtggtgctc gcgctgcgcc tgggacgggc cccggcgccg catcggcact ggcgcacggc
     8401 cttctggtgg gtcgggatcg cggcgctcgc cggatccgtc caccacgggc tgatcacgta
     8461 ctcggagcgg tggtcggggc cgagctgggc cgtgatcagc ggcatggtcg tcgtcgcggt
     8521 gtcctacctg ctggcggcca ccgtcgccga ggtgctcggc ccgcaccacg gcaggacgtt
     8581 ctggctgctg cgctcgatcg ggatcgtcgc ctacgccgtc ctcgcggtga ccggacacgc
     8641 cggggtcggc gccctgctcg cctgcgagag cctgacgatg gtgtgcatcc tcgcgctctg
     8701 gggctgggcg gcatggcacc gccacccgat ggccggcccg gtgatcgtcg cgctggtcgc
     8761 cagcgccgcg gcggccgcga ccaaggcgat cgacccgagc gtcacccgcc gcgtcgcgct
     8821 ggacccgacc tcggtctacc acctcgccca gatcgtcggg atggtcctgc tctacctggc
     8881 ggtcaccaag ccgcgccgcc cggatcgccc ggaccgcgag ccgcgcgccc tcctccgata
     8941 gcacgggctc ggccggtcgc gcggcgccgg cggacagcag tggccgcggt ggcacattcc
     9001 cctaacggag gtgtcttcct tctgtgctga agggtggcct ttcggacacg gacggtcacc
     9061 attagctttc aagccgtgat ccgaaaccac cgtccccgtg gaggaaagcg ttcatgacgg
     9121 ccatcgccag cgtctaccag cacgacgtcg ccacctactg gaacaccgag cgcaacccgg
     9181 tcaacctgcg cctcggcgac gtttcgggga tctaccacca ccactacggc atcggcgagg
     9241 tggactggtc ggtcctggag accccggagg acgcccgcga agaggcgatc atcaccgagc
     9301 tgcaccggct ggagaacgcc caggcccggt tcctgctcga acacctcggc gacgtccggc
     9361 ccgaccaccg gctgatggac gccggctcgg gccgcggcgg ctccagcatc atggccaacg
     9421 ccgccttcgg ctgccgggtc gacggagtgt cgatctccca ggcccaggtg gacttcgcca
     9481 acgggcaggc cgcccagcgc ggcgtgtccg acaaggtccg gttccacttc aagaacatgc
     9541 tcgacacggg gttcgaagcg ggcgcgttcc aggcgatctg gaacaacgag tcgacgatgt
     9601 acaccgtcct ggacgacctg ttcgcggcgc actcccggct gctggcccgc ggcggccggt
     9661 acgtcaccat caccggctgc tacaacgacg tgtacgggct gccgtcccgg gcggtgtcga
     9721 ccatcaacgc ccactacgtg tgcgacatcc acccgcgcag cgcctacttc cgggcgatgg
     9781 cggccaaccg gctcgtgccc gtcaccgtgg tcgacctgac cgccgacacc atcccgtact
     9841 gggagctgcg cgagaagtcg tcggtcgcga cggggataga gagcgccttc ctggaggcgt
     9901 accgcgacgg cagcttccag tacctgctca tcgccgccga ccgcatctga acccgtcaac
     9961 ccggaccggt cgccttcggg cggaggcagg tgagcagacc atggaaacga cgcaccacgg
    10021 gtgcagcggc cggcgcgcgc cgtacggctc gtccgcggaa ccccggccgg agcgaccgtc
    10081 cggggtgggg accgaggcgg tgtccctgcc gtcgctgatc gccgcggcac gtcccagccg
    10141 ggagccgtcc tacggcgacc tcctggccgg gaggcatccg cggccggtcg gcggcggggg
    10201 gcccggctac gtcgagcgcg cctgggggga cgggtcgcac tccccgctct actgcccgct
    10261 ccccgagcgc gccgacgacg ccctcgccgc cgaggtcgac gcccggctgg cctcctgggc
    10321 gcgcgaccgc gggttcgacg accacgagct cgacgcgctc ggcaaggcgg ccttcggtcg
    10381 gctggtcacc ctcgcccacc ccgacaccga cgacccggac gccctgctcg tcgccgcgca
    10441 gatgaacgcc gggtggtggg cggccgacga ctactacgcc gacgacaccg ccctcggcgc
    10501 cctgcccgcg atgctgccgc agcgcctcac gctggtgatg tcggcgatgg accccgtccc
    10561 gcccgcgggc gagttcaccc cgccgctgag cgaggccctc cagggcgacg tcgtcctgcg
    10621 gatgctcggc tcggcggtcg accacctgaa gcgccacgcg tcccccgtgc aggtccagcg
    10681 gatctgctac tccaccttcg ccatgttcgt gagctggacg gcctacgcgg cctggcgcga
    10741 gaagggcgag cacccgcccg cctgggagta tctggcggcg cgccagcacg acagcttcta
    10801 cacctcgatg acgctcatcg acgtcctcgg cggctacgag gtcccggccc agctgtacta
    10861 cgacccgcgc gtccgccgcg ccgccttccg ggccgggacg gcgagcgtga tcgtcaacga
    10921 cctgcactcg gtggccaagg acgccgccga cgagaacccg gtctgcaacc tggtgctgct
    10981 gatcgccgcg gacgagggct gctcggtgga ggaggcgacc gagaccgccg tgcgcctgca
    11041 caacgacctc gtccgcgact tcgaggccgg ccaccgggag ctcgcgggcg tcccctcccc
    11101 cgagttgcag cggttcctgc gcgggctgcg ggcctggatg ggcggcggct tcgaatggca
    11161 tgccaccaac ccgcgctacc gcgagggtgc ctgagggccc gccgttcccg tggcgtccgg
    11221 cgccgggcag ccctacggcg ccgtcgcccg caagccctga cccggcctgc cgctcctcat
    11281 cccgccccgc gggtgatcgt tgtcggcagc tcggcgaacc cgcgcgcgta cggcgagttg
    11341 acgcgccggg ccccggcctc gtcgatgtcg tagccgccgg tgcgggccgc gagctcctcc
    11401 agcgcgaccc gggcctccag ccgggccagg tgcgcgccga tgcagtagtg ccgccccgac
    11461 ccgaaactga tcttggccgt ggtgtcgcgg cccaggtcga accggtcggg ctcggcgaac
    11521 acgcgggggt cgcggttggc cgcgcaggcg ctgctgcggg ccggggagct ggacgagctc
    11581 gaactgcacg tcgtccccgt cctgctcggt cagggccgcc gcctgttcga ccacctgccg
    11641 cccgaccacc acgaactgcg cctgatccgc cagttggcca cgccggagac cggggacccc
    11701 gcgcaggccg tcctgcacct gcgctaccgc gtcctccgtc cctgagccgg tgtcgccggg
    11761 gtcccgtctg agtaccgcag cgtacgaaca tgagtagagg cacggatcga tcaggcgacc
    11821 ggagactgtt cactgggctc gtgaccacag agaacaccgt tgcgggccct cggaagcgct
    11881 cgggctggcg agtggccgcg gcgagcacgc tcgccctgct ccttcccgtc accgtgctcg
    11941 cctggatcgc cgtgctcgcg accccggagt acggccgatg cctcacctac ggggagcagt
    12001 gcgatccggc ctccgacgtc ctcctgccca tcgcttggtg gtgcttctgg ggcagcggcg
    12061 ccgccggcgt catcgcgctg ctcctccggt ccccctggac ggtgacctcg cggatccgcc
    12121 cggtcctggt catcgggcaa gtggcgcttg cgatcgtgac cccgacggcc gtgatcgtca
    12181 gtggatgagc cggccgccat gtgaggtagc tcacgggaac ccggtcgctc cggcgaacag
    12241 tccttcctgt ggagatgagt atgcgtgccc gggttcattc cggggatccg gatgcgttca
    12301 gagaactgtt cgacgaacat gtgcgctcgg tgtacaacca cgcgttccgc ctgacgggga
    12361 actggtcgac cgcagaagac gtcgtgtcgc tgaccttcct ggagtcatgg cggctgcgcg
    12421 agagggtcga cgtcgaggtc gaggggtcgc tgcgtccatg gctgctgggc atcgcgacca
    12481 acgtcgcccg caacgtgcgc cgcgccgccc ggcgccatga cggcgccctg gcgcggcttc
    12541 cgaggaacga cgtcgtgccg gacttcaccg acgaggtcac gtcccgcatc gacgaccgcg
    12601 agcggctcgc cctgatgcgc acggccctgg cggcgctgcg caagcccgag cgcgaggtgc
    12661 tggcgctgtg cgtctggtcc gggctcggct atgccgaggc cgccgaagcg ctcggcgtgc
    12721 cggtcggcac cgtgcgctcc cggttgtcgc gcgcacgcaa gaagctggaa aggctcgcca
    12781 ccgcgagtgc ggggccgccc ggagaacgcc gggaaccgct tcccggccac ggacaggaag
    12841 aggatgaccg cgcgatcgcg gtccggtccg ctcaggagag aacccgatga accccacccc
    12901 gacccagccg aactcgaacg aacacgagga gctggcacgg ctgctgccgg ctccggtgga
    12961 gcgggacctt ccgggcgacc gtcaacaacg actccgggag ttcgtgatga gcgagatcga
    13021 ccaggacctt cgaccggccg agcaggcctc gcgccgttcc gcacgacggc ggcccgtcat
    13081 cctggcctcg gcgggaatcg ccgcggccac cgcggccgcc gcggtggtgg tcgggatcgc
    13141 cggcaccggg ggcgccgagg gggcgaagga gagtccgtcc gcgtccgcca cgggctcccc
    13201 ctccggtcgg caggtcctgc tcgtggccgc caccaccgcg ttgaaggcgc ccgcgggttc
    13261 cggtacgtac tggcacgtca agacgatcta caccgaccgc gacggcggtg cgcgcaccac
    13321 catggagagc tggacccggc gcgacggccg ggtctggtgg aagggaggga agacccaggg
    13381 cagggtggtc atgctcaccc ggcccgctcc gttccggctg ggcgggcccg ccgtgacgct
    13441 cgcgcagctg caggggctgc cgaccacacc gggcgggctg aaggcgtgga tcgtcgccgc
    13501 cgtgaagaag agcgacgtca cgaccagcgc cgggcgcccc gacgcggccg cgcaggagcg
    13561 actcgtcttc gaggggctgc tgtccctgct ctcccagctg ccggcgccgc cgcaggtccg
    13621 cgccgccgcc ttccgcgcgg tcgcctccta ccccgacgtc gaggacctcg gccccgtcaa
    13681 gggcgggcag ggcctgtcga tctccttcgg cggggggcgg aaggcgaacc tggtcatcga
    13741 cccgaagacc tcgcggatca ccgacaccga ctacttcgtg tcggccgacg gcgcacaggt
    13801 cacggctccc ggcggcgccg agatcgtggc cgagtggacg agcgtggcgc ccgggtagcc
    13861 gatccgcgca cggggatcgc ctggacctgc atgatcgggc cgatcatgca ggtccagggc
    13921 ggggggctac tccccggcgc tgtcggccgc ctcgaccgcg gcgcgggact cgatgatctc
    13981 ctgctgggcc cgggtgtggc cctcgatgat gatcttgacg acctcctccg ggtcgtcggt
    14041 gaggtggaac aggtcgatgt cctgcggcga gatcttgccg gaggtcagca tcgactcctt
    14101 gacccagtcg agcaggccgc cccagaaccg cgtgccgacc agcacgatcg ggaagcgggt
    14161 gatcttcttg gtctggacga gggtgatcgc ctcgaacagc tcgtccagcg tcccgaaccc
    14221 gcccggcagg acgacgaagg cctgcgagta cttgacgaac atcgtctttc tgacgaagaa
    14281 gtaccggaac tccaggccga tgtcgagatg gtcgttcagc ttctgctcga acggcagctc
    14341 gatgccgagg ccgaccgaca ggccgccgtt ctcgtcgcag cccttgttgg ccgcctccat
    14401 gatccccggg ccgccgccgg tgatgacggc gtagccggcc tcgtgcaggc gggcgccgat
    14461 gtcgacggcg agctcgtact ccggggagtc cggcttggtg cgggcgctgc cgaagacgct
    14521 gacggccttc ggcagctcgg cgaggaggcc gaagccctcg acgaactccg cctggatccg
    14581 cagtacccgc cacgggtcgg cgtgcaccca gtcgaccggg ccgcggccgt cgagcagccg
    14641 ctggtcggtc gtggtcgggg ggacggcccg cccccgcagc atggccggcc cctgccggcg
    14701 cgagcgggaa ttcacttccg ttgtcatgaa gccacggtaa tgggaccctc cagccacgtg
    14761 cgcatacgtt gctcgcactc ggcgatgagg gggatctcga cgtactcgtc ccgtgtgtgc
    14821 gcgagggtcg gctcgccggg gccgtagttg acggccggga caccgagttc ggcgaagcgg
    14881 gcgacgtccg tccagccgag cttggcgcgg acctcggcgc cgctcatcgc ggcgaacgcg
    14941 gcggcggccg ggtggttcag cccggggcgg gcggcgggcg cgccgtcggt gaccgtcacc
    15001 tggaagccgg cgaagatttc cctgaggtac gcctccgcgt cggcgaggga cttgtcgggc
    15061 gcgaaccgat aattcacggt gacgacgcac tcgtccggga tgacgttccc ggcgacgcca
    15121 cccgagatga acaccgcgtt caggccctcg tggtactcca gcccgtccac gaccggacgt
    15181 gacggctcgt aggcgcgcag gacgtccagg atcgccccgg cggagtggat cgcgttcgac
    15241 cccatccagg cgcgagcgct gtgcgcccgc tcccccgtcg cggtgatctg gacgcgcatc
    15301 gtgccctggc agccgccctc gatcaacccg ccggtcggct ccatcagcac ggcgaagtcg
    15361 cccgcgagca gttcgggccg ggactccgcg agatgccgca gcccgttgcg cgcggcctcg
    15421 acctcctcgc agtcgtagaa gacgtaggtg acgtcccggc tgggcgcctc gacggtcgcg
    15481 gcgagccgga gcgcgaccgc gacgccgctc ttcatgtcgg tggtgccgca gccgtagagc
    15541 cggtcgccct ccacgcggga ggggaggttg ccgttcagcg ggacggtgtc gaggtgcccc
    15601 gccagcacga cgcgttcggc ccgtccgaga tcggtgcgcg cgacgacgtt gttgccgacg
    15661 cgctccaccg ccaggtgcgg cagcgtccgc agcgcctcct cgacggctcc ggccagggat
    15721 tcctccccgc cgctcaccga ctcgatgtcg acgaccgccg ccgtcaggcc cgcgacgtcc
    15781 gagtacagat caagccccat ggccgaaggt tatctatcat cgcgttcgtg gagatgcccg
    15841 tactggagtg cgccgtccat tgggcgcgtc ccgccgacga cccccggatg cgcgacctcc
    15901 tggacgacgg ggagcgcgac cgctacgcgc ggttcatgcg cgccgaggac aaggcccggt
    15961 tcgtcaccgg gcggttcctc gcgcgcacgg tcctcgccga ggccaccggc cggcccccgc
    16021 acgacctgca cttcaccacc ggctgccccc actgcggcga cgcgcacggc aagccgcgcc
    16081 tgcccggcag cggcctggac ttctcgctct cccactcggg cgaccgcgtc ctgctcgtcc
    16141 tggtcgaggg cgccgaagtc ggggcggacg tggagcagga gagcgaccgc gacgtcgaca
    16201 gcctctcccg gatggtcctc accgccgccg aagcggaggt actcaggacc atggccgacc
    16261 ggaaacgcgg cttccacgcc tactggagcc gcaaggaggc gctcctgaag gccaccggcc
    16321 acggcctggc cgccccgatg accgccatcc acgtctccgg ccccgacgag ccccccgagg
    16381 tcgtcgcctg ggagggcgag gcggccgtct cccccgtccg gctcgccgac ctggacgcgg
    16441 gccccggtta cgccgcctcg gccgccgtcc tcaccgaccg tcccctcagg ctcgccgagt
    16501 tcccgctcag gtgttgatgc cgtggtcgcg gaggatgtcg ttgagggacg ccttgtcgtg
    16561 gcgctgcccc tcctccagcc gcttgaggat cagcaccgcc ggaagcccga acgtgccgcc
    16621 cttgaactcc ttgtaacggg tgccgcccac cgcgacgcac cagtcgggga tgcgcccgcg
    16681 gctgatctcc tcgcccgtct cgacgtcgat gaccggcatg gacgccgaca ggttcgtccc
    16741 cgacccgacg acggcgccgc gcccgacccg cgccccctcg acgatcatgg accggctgcc
    16801 gatcatcgcc tcgtcctcga tgaccaccgg cttggcgttc ggcggctcca gcacgccgcc
    16861 gatgccgacg ccgcccgaca ggtggacgtt cttgccgacc tgcgcgcacg accccacggt
    16921 ggcccaggtg tcgaccatcg tcccggagtc gacgtaggcg ccgatgttgg tgaacgacgg
    16981 catcagcacc acgcccggcg ccagatgggc gccccaccgc gcgatggcgc cgggcacgac
    17041 gcgcacgccg tccaggcgcg tcttcaacgg gatgcggtcg tggtaccgga agtcgcccac
    17101 ctgcgatcgc gccatgccga ggaccttgaa gctcagcagg atcgcccgct tggcccgctc
    17161 gtcgacgacc acctcgtcgg tcgcggggtc gatccgggcc acgcgggcct ccccggagtc
    17221 gagctggtcg acggcggcga cgatcgccgc gcgcgccccg gcgtcgtcgg gcgtcagctc
    17281 ggcgcgccgc tcccacaact cgtcgatgtc gccggagatc gggctggtga acgtttcggt
    17341 catgcctcct gagcttactg gtggccatct cccagtactg tcttcgcgtg gctgtttggg
    17401 cgaggttgaa ggcgcgcccc gaggaggggg cgagcggcgg gcgccgccgg cgcggcgtcc
    17461 gctgggccgc ggtcctgtgc gtcgtcgtgc tgctggtggg cgtgggcgtc tacgtggcct
    17521 tccagcgagc gcgcccgtac ctgcacgggt ccggctgcga ggtgcgcacg agcctgggca
    17581 agatgccgct cgacctggag cagggcgcga acgccgccac cgtcgccgcc gtcgcgttcc
    17641 gcaagcagct ccccgaacgc gccgtggtga tcgcctacgc gaccgcgatc caggagtcgc
    17701 acatccacaa cctgccgaac ggcgaccgcg actcggtggg catgttccag cagcgcccgt
    17761 cccagggctg gggcacgccg gacaaactcc gcgaccccgt ccaggccacc agcaagttct
    17821 tcgacgccct cgtcaaggtc aaggactacc tcgaccgcga cctgcacgac gcggcgcaga
    17881 aggtccagcg cagcgccgac ggccgcgcct acgcccagca cgagcccgac ggcaagctcc
    17941 tcgcgaccgc cttcaccggc cgcgagcccg ccacggcccg ctgctggtac ccgcccgaca
    18001 agaagacgac gtcccgccgc cccgaggccc tcctggagat gcgccgcgcc ttcggcagcc
    18061 gcctcaaggt cggcggcccc ggccccctga aggcgggctc cccgtccgac ccgaaatcgt
    18121 ggaacgcggt ccaggtcacc aacccccgct cgggctgggc ggtcgcgagc tgggccgtca
    18181 cccacgccca ggcctacggc ctgaccgagg tccgctacgc gggcaagcac tggaagtcca
    18241 acgccggcca cgacggctgg accgcagacg aacaagccgc ccagaccacc gtcatcgtcc
    18301 agtagccctc cgggtgtgcc cccctttccc gttcgcgacg ccgagcccga gcaggccgtg
    18361 cccgccggtc ggatgggcta cgacctcgac gcggagcggc tgctgcttca caccgtccag
    18421 tcggccgagg cgttcgaggc cctgctcacg acgggcaccc tgacgacgga cccggacctg
    18481 gcggaggccg agttcacgga cgcctacgac tggatccacc ggatgatggc ggcccgcctg
    18541 ccgaccagcg gcgagggcgc actgtggctc tgggcacgca cccgccgcga gcatctggtc
    18601 gacagttgcc gccgctcgcg cggccaggta ctgctcacct gccgggtccc gcgcgagcgg
    18661 gtgctcctct cacacttcga cgagtggcat ctggtcctga acagggccct gggaatgccg
    18721 aggctgccgg gcgagtccga ggacgacgcc ttcgcccgct gggaggaggc acaagacgtt
    18781 ttcgacgccc gtctacgagc agcgggactg cgcgacgccc cgatccgaaa ctggaccccc
    18841 gacctgcgga acgagatcga gacctcctgg gaatgcatcc tcgaccgagc caactacggc
    18901 ccgtccgagt gctggcaggc caccgtgcac gccttgaaca ccaacgacgt ggtggaagcg
    18961 acccgaatca cctgaagcga gggcgaccgc cagggctccg gcgcgtgggc ctgacattcg
    19021 cattctgcgg aacggttggt gtacaacttc gccatggatg ccgtggacct tcagaagctg
    19081 ctcgacaagg ttttcaaaca ggcggtggtc tatcacgggt ttgtcgacta catgcgcgac
    19141 tacgaggtca tcgtccgccc gtccggagat cctgtgaccg gcgttcgtcc tgcccatctg
    19201 cggtacctgt tccggtactg cgttgannnn nnnnnnnnnn nnnnnnnnng gcccgctgcc
    19261 agacgaccct gtccgctgat gcctggacag agtcgctgga cgaccgtctc accgactacc
    19321 ggagcggcgt tgatatctac ggctatctct ggggcgtgaa atggcacgtc ctctatcctg
    19381 gggcgagcgt ggtcgctgag tcgaagtcgg ccgacaaatg gactgcggcg cttggaatcg
    19441 acttccacga ggtacgcatc gagaccaacg cacatgacct gacgctggtg ttctccgacc
    19501 tgcagacgag cgaagtgccg gccggccacg ccccattcac tgtcggcgaa ggccccgcga
    19561 ggccataaga cggctcgact ggacacgcca catcggtgtc cgatgccgaa cggggccttc
    19621 ggccggtcac acctcgtccg tccggtcgcc cttcgctcac ttgtcactcg tttaccgtgc
    19681 catgagcaac ctcttcaaga cagcaccctt ttctttgcct ttgggcggtt gtgccggtga
    19741 ccttggtaaa gggcatatcg acgagtggcc cgggggttgg ttggggggcg gctgggcggg
    19801 aaatcgtgga cgcatggaga taccacggac gttggtgctg accgggcatt ttccaccgga
    19861 gcccggcggg gtgcagacgt tcacgtggga gttggtgcgg cggcttcccg ccgaccggct
    19921 ggtcgtcgtg gcgcccgcgt ggccgggggc cgcggagttc gacgccgatc tcgggttccc
    19981 cgtcgtccgg cggcacgcgt acctgctgtt ccgggggctg cggcggctcg tcgtgcggca
    20041 tcgggtcgag gcggggtgga tcacggcggc ggcgcccttc gggatgtacg cgccgctggt
    20101 gcgggcggcc ggggtgcggt ggctggtcgg gtccgcgcac gggcaggagc tggggtggtt
    20161 ccgtgcgccg ccgacgcggc tggcgctcag gacggcggcg cggtcgttcg acgtcctcac
    20221 ccatctcagc gcgaccacgc tgccggagct gacggacgcc gtcggcgacc ggacgcggct
    20281 ggcgcggctc gccggggcgg tggacaccgt gcggttccgg ccggggctgg acgggacggc
    20341 ggtccgccgc cggcacggcc tcggcgacgg gccggtggtg ctcagcgtcg cgcggctcgt
    20401 gcggcgcaag ggccacgaca tgctgatccg cgcgtgggcg gacgtggtgc gccggcgccc
    20461 ggacgcccgg ctggtgatcg tcggggacgg tccgatgcgg cgcaggctca ccgagatggc
    20521 ggaccgggag gcgcccggga cggtcacggt gaccgggccc gtctccgcgg cggagctgcc
    20581 gcgctactac gccgccgccg acgtgttctc gctgccgtgc cgcgacgacc gggccgggct
    20641 tcagaccgag gggctcggcc tgtcggtgct ggaggcgtcc gcggcggggc ttccggtggt
    20701 ggtcggccgg tccggtggca gccccgagtc cctgatcgac ggccggacgg gggtcctggt
    20761 cgacgccacc ggaccggacg agatcgccct ggccctgcac cgcctgctcg gctcccccgc
    20821 acgcgccgcc gcgatggggg ccgcgggacg gcgatggacg tgcgaacgct ggagctggga
    20881 cgccgccgcg gcccggctcg ccgccctgct gaagggctcc gtcctcgacg cgccgcccaa
    20941 gcacgacaca ccggggatgg agcccgcatg ggactcaggg agcagctgaa caagcgcgac
    21001 ttccggcggc tcatcgtcgg ccagacggtg tcctcgttcg gcgactggat gggcacgctg
    21061 gcgctgatgt acttcgtgct ggagctcagc gactccacga cggcggtcgg cggcgtcctg
    21121 gtgctgcggc tgctcccgtc cgcgctcggc gcgccggtgg cggcgcgggt ggtgacgcgg
    21181 tggcggcggc ggag
//
