LOCUS       NZ_BMRD01000010        10807 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence10, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000010
VERSION     NZ_BMRD01000010.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 283096)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 117784
            Orig. end                         :: 128591
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10807
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10807
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10807
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5807](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5807
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(<519..602)
                     /locus_tag="IEZ14_RS42880"
                     /pseudo=""
     CDS             complement(<519..602)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF026214.5"
                     /locus_tag="IEZ14_RS42880"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MALTQPQLLAVLTGKDAQDAAMEGDTSA"
     gene            complement(<617..1180)
                     /locus_tag="IEZ14_RS23645"
                     /old_locus_tag="GCM10010177_47740"
                     /pseudo=""
     CDS             complement(<617..1180)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017555972.1"
                     /locus_tag="IEZ14_RS23645"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_47740"
                     /product="MBL fold metallo-hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTDLPFSDRSDFDNADRGHIASRTPGIVTNAQGQTVWDGDVFSFL
                     DGECPQSVHPSLWRQSQLCAKQGLYEVAAGIYQVRGLDLSNMTLVEGDKGVIVIDPLIS
                     NETAAAALALYREHRGDRPVTGLLYTHSHIDHFGGAGGVLPPGNPEGAPILAPAGFTEN
                     AVAENVYAGTAMARRGVYHTGATLP"
     gene            complement(1301..2659)
                     /locus_tag="IEZ14_RS23650"
                     /old_locus_tag="GCM10010177_47750"
     CDS             complement(1301..2659)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891158.1"
                     /locus_tag="IEZ14_RS23650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_47750"
                     /product="MFS transporter"
                     /protein_id="WP_179838801.1"
                     /transl_table=11
                     /translation="MIVLCLVQFMLVLDDTVVNVALPSIRDDLGFSASGLPWVVNAYFL
                     AFGGLLLLCGRMADLLGRRRVFLMGVALFGVASLACGLAQEPWQLVIGRFVQGTGSAMA
                     GPAAMSMITLLYPRTEERTRALGIWGGIAALGGTSGLVISGALTDLVTWRWIFLINLPV
                     VAVALALLPGLVPESRAPGRRGLDVPGAVLVTGAAVSLVYGLLRAGETGWSDPIAIGAV
                     ALSAALTVAFLVTESRTAAPLVPKSFLASRTRAVANGATLLFSMAMYAMSFLLMIQVQT
                     ALGYSPLLAGIAYLPYGGGILAGMWSSSRISLRIGTRWALLLAFLVNIAGLLLLSGVAA
                     GDSYAAHVLPGMLILSVGNGLSLPVMAVAAVDGTTEEDAGLGSALFTSVQQIGGAVGVA
                     ALAVMGYSGGLTAGAVCVALGAVLIVVLLPSRTSGPQQPAGHGAGGRSTPVGS"
     gene            2727..3461
                     /locus_tag="IEZ14_RS23655"
                     /old_locus_tag="GCM10010177_47760"
     CDS             2727..3461
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891159.1"
                     /locus_tag="IEZ14_RS23655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_47760"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_179835583.1"
                     /transl_table=11
                     /translation="MEDMAAIIVGHFPLASGEWIPPHSHTHHQLAWTRRGVLSVGVDEV
                     YWVLPPTRALWLPAGVTHTTGATREAVLCSLYLAPERCPVNWVEPTAVGVDGLLAELIG
                     YLARTDLTDDARSRAEALVPDLLRPLPTRPIDVPQPTDERVRAVAAALLADPADPRGLE
                     AHARAAGVSRRTLTRLFVHDTGMSFDQWRTQARLRAALPLLAEGQPVSRVAHSVGYATA
                     SAFLAAFRRTVGTTPRRYLHSR"
     gene            3931..5004
                     /locus_tag="IEZ14_RS23660"
                     /old_locus_tag="GCM10010177_47770"
     CDS             3931..5004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017540968.1"
                     /locus_tag="IEZ14_RS23660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_47770"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_179835582.1"
                     /transl_table=11
                     /translation="MPQPGEPQDVLAPPAVAAIFLVVTVRPGGEDAVRGLLPDIAGLTR
                     AVGFRSPEGGLSCVTGIGAELWDRLYGPPRPAGLHPFRVLGGAVHTAVSTPGDLLFHLR
                     ARRMDLCFELAGQLMNRLARYVDVADEVHGFRYFDERDLMGFVDGTESPKGRDGVVAVR
                     IGDEDPAFAGGSYVVVQKYVHDLQEWDALPVEAQELAMGRTKLNDIELPDEMKPSNSHV
                     VLNTITDADGNQRQIVRDNMPFGTVGAREFGTYFIGYTASVEVIERMLENMFIGDPPGN
                     HDRILDFSTPVTGGLFFVPTADFLDDPSPQLAAAAAASADKPGPDAQAAEEPAARAPTS
                     PDDGSLGIGSLKGHGTS"
     gene            5001..5807
                     /locus_tag="IEZ14_RS23665"
                     /old_locus_tag="GCM10010177_47780"
     CDS             5001..5807
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083253.1"
                     /locus_tag="IEZ14_RS23665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_47780"
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_179835581.1"
                     /sec_met_domain="Linocin_M18 (E-value: 9.5e-91, bitscore:
                     297.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLHRELAPVSDAAWAGIEDEVRRTFTRHVAGRRVVDLVGPAGT
                     ELNAVGTGHVRPFDAATEGVLLHRRETQPIIEVRVPFTVTRQAVDDVERGALDSDWGPA
                     KDAAKRAAFAEDHAVFHGSDPASITGIVPGSSNATLPLPPDVRQYPGAVAKALTALRLA
                     GVNGPYSLLLSADAYTAVTETTDHGYPIHHHLARLLRDGEIIWAPALDGALLLSTRGGD
                     YELHLGQDLSIGYLSHTADRVDLYLQESLTFLSITAESSVPLSAGG"
     gene            6065..6652
                     /locus_tag="IEZ14_RS23670"
                     /old_locus_tag="GCM10010177_47800"
     CDS             6065..6652
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018745.5"
                     /locus_tag="IEZ14_RS23670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_47800"
                     /product="DUF1345 domain-containing protein"
                     /protein_id="WP_218935216.1"
                     /transl_table=11
                     /translation="MTAGILVCVLVGVLASVPLGVLSGIAVAIAVFVTTGVALLWPMTA
                     EDTRRNARREDFQPLMAESLIVTVAVASLAGVAVLLAIGSSATRNGAAAIGLFGVFMSW
                     AMLHQLYAIRYAHLYYGEPSGGIDFNSDEQPAYRDFLYFSYNLGMTYQVSDTDVSSTVI
                     RSVVLRHTLLSYVFGTVILAATVNLVMGMISS"
     gene            complement(6701..8128)
                     /locus_tag="IEZ14_RS23675"
                     /old_locus_tag="GCM10010177_47810"
     CDS             complement(6701..8128)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015043.5"
                     /locus_tag="IEZ14_RS23675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_47810"
                     /product="carotenoid oxygenase family protein"
                     /protein_id="WP_179835579.1"
                     /transl_table=11
                     /translation="MVAHSTEFDPTRVAHLNGTFAPVSEEVDEAELQVEGELPADLDGV
                     YLRNGPNPRFTPIGSYLFPIDGDGMVHGVWMSQGKARYRNRFVRTPALRAEEAAGRALW
                     GGIESMIIPGAEEVGPALAQTFKELPDINIVRHGGRLLALAESDCPYRMSPELETLGRE
                     TFGDGLPAGITAHPKVDPRTGQMAVFCYALEEPFLTWSLLGADGSLDRGPTAVEGPEEP
                     VMIHDMALTGRYLVLVLAPAFLDLAAALQGGSFLDWRPERGTRIALIPRDGGPVRWARD
                     TAFWVWHTVNAYDTPDGQVVLDYVQWPGPGLGPRPAAPGGAPHGLARAVLDPDAGSIRR
                     RLLDDVRVEFPRVDDRVLAGPHHRIATAAGSGRTPDLLPGEYDALRWYEVSSDDVVAET
                     WNAGALSVGEPVFAPVPGTTDAGDGYWLTFATDRTDLTSWLLVLPGQNPADGPVARVRI
                     PVRVPLGLHGAWLPTQN"
     misc_feature    complement(8345..8360)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     misc_feature    complement(8354..8369)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.32"
                     /tool="antismash"
     misc_feature    complement(8361..8372)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.47"
                     /tool="antismash"
     gene            8467..9606
                     /locus_tag="IEZ14_RS23680"
                     /old_locus_tag="GCM10010177_47820"
     CDS             8467..9606
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013088.5"
                     /locus_tag="IEZ14_RS23680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_47820"
                     /product="EamA family transporter"
                     /protein_id="WP_179835578.1"
                     /transl_table=11
                     /translation="MRVGGDGALRGVAVGLLGLLFCVAGDAFSALGAEDQFPFAPGALG
                     AVFGGLFLAGYAVVKIGLSVRSRGGSAAEEIQRVRASAGSVRWPIGCLAVSGVFYLPLL
                     VGATQRIGSFATVIAIAFCGPLGVAVWGTLRKARYVAVLWPVLAGVGLWVMSLQEESRI
                     DWLGYAFAAVAAVCFAVNVSAVEKLEDRGAETIGLALAGLLTIPGAACWLVVGGLDWFQ
                     PRVLMLAMLTGLCTACVAPVLEARSIGYLGKEKFGVLSSGEPIMSLPIGLLLLGETPGW
                     FVATGVLIIVVAIVANTTDLDEPLLRWLGRRDLGRLRGSRRLAKAAVPADGAARTADSQ
                     SLEVAAALWPLAQGGNTKAAALLTGVLTPVAERAGLTKR"
ORIGIN
        1 atcgccgggg cggccggcgg agtggtctcc accgcgcatg acgtcagcgc cttccaacgg
       61 gccttcgccc agggcaaact gctgccgccc gaactccagc gagtcctgac cgaccgactg
      121 cccggtggcc cgcagcccct gggcaagagc cgcagctcat gcggcgacga tctctacatc
      181 atgggcggga ccgcccccgg cttcctcgcc atgaccttct actcagaaga cggccgccgc
      241 cagctctcga tgtcggccac cctgagcggc aaggacaccg ccggggcggg ccaagccatg
      301 ggcaaggcca tggagaccat cttctgccca tcctcgtagc gccggctccg ggaccctccg
      361 ccccgtgcca gaggctgaag gtgagggcat ccggttccga gggatgccct catcggtcgt
      421 ctggcacagg aacgcgcgga cggtgccacc ctgctgtcag gggtgacgat ggggaaggcg
      481 gggtccgggt tgtccaggac tcccatcagg cggtccagtg ccgacgtgtc gccctccata
      541 gcggcgtcct gggcgtcctt gccggtgagt acggcgagca gttgcggctg ggtgagggcc
      601 acggtcaggc gtttttggga agggtggcgc cggtgtggta aaccccgcgc cgtgccatcg
      661 cggttccggc gtagacgttc tcggcgacgg cgttctcggt gaacccggcc ggcgccagga
      721 tcggtgcgcc ctcggggttg ccgggcggca gaacgccccc ggctccgccg aagtggtcga
      781 tgtgggagtg ggtgtagagc aggccggtga cggggcggtc gccgcggtgc tcgcggtaca
      841 gggcgagcgc ggcggcggcc gtctcgttcg atatcagcgg gtcgatcacg atcacgccct
      901 tgtcgccctc gaccagagtc atgttcgaca ggtcgagccc gcggacctgg tagatgcccg
      961 cggccacctc gtacaagccc tgcttggcgc acagctgcga ctgccgccac agcgacgggt
     1021 gcaccgactg agggcattcg ccgtccagga aggagaagac gtcgccgtcc cagacggtct
     1081 gcccctgggc gttcgtgacg atcccggggg tgcgggaggc gatgtggccg cggtcggcgt
     1141 tgtcgaagtc gctccggtcg ctgaagggca gatcggtcat gtccgggcga ttgccgcatc
     1201 caaggcagga gagagaaagc ggactctggt caaatcctcg ccctggcccg gcgttgtctc
     1261 cgccgttgtc gcgacgtcat cgttcagccc gcctcaccac ctacgaaccc acaggtgtgc
     1321 tccggccgcc ggctccatgc ccggcgggct gctgggggcc gctggtacgc gacggcagta
     1381 gcacgacgat gagcacagct ccgagcgcca cgcacaccgc gcccgccgtg aggccgcccg
     1441 agtagcccat gacggccagc gcggccaccc cgacggcgcc gccgatctgc tggacggagg
     1501 tgaacagggc cgagccgaga cctgcgtcct cttcggtggt gccgtcgacc gcggctacgg
     1561 ccatgacggg caggctcagc ccgttgccca cgctcagtat gagcatgccg ggcaggacgt
     1621 gggcggcgta ggagtcgccc gccgccacgc cggacagcag cagcaggccg gcgatgttga
     1681 ccaggaacgc cagcaggagc gcccagcgcg tcccgatcct gagcgagatg cgggaggacg
     1741 accacatgcc cgccaggatg ccgccgccat agggcaggta ggcgatgccg gccaggagcg
     1801 ggctgtaccc cagagcggtc tgcacctgga tcatcaacag gaaggacatc gcgtacatcg
     1861 ccatcgagaa caggagggtc gcgccgttgg cgaccgcccg cgtccgcgag gccaggaacg
     1921 acttgggcac cagcggtgcc gccgtccgcg actcggtcac caggaacgcc accgtcaagg
     1981 cggcggacag cgcgacggcg ccgatggcga tcggatcgct ccagccggtc tccccggccc
     2041 gcagcagccc gtacaccagc gacactgcgg caccggtgac caggaccgcg ccgggaacgt
     2101 cgaggccgcg ccggccgggg gcgcgggact cggggacgag gccggggagc agcgccaggg
     2161 ccacggcgac gacgggcagg ttgatcagga agatccagcg ccaggtcacc aggtcggtca
     2221 gggccccgga gatcaccagg cccgaggtcc cgcccagggc cgcgatgcca ccccagatgc
     2281 ccagtgctct ggtccgctcc tccgtcctcg gatacagcaa cgtgatcatc gacatcgccg
     2341 ccgggccggc catcgcggaa cccgtgccct gcacgaaccg cccgatcacg agctgccatg
     2401 gctcctgcgc gaggccgcag gccaggctgg ccaccccgaa cagtgccacg cccatgagga
     2461 agacgcggcg gcggcccagc agatccgcca tccggccgca caacagcagc agcccgccga
     2521 aggccaggaa gtaggcgttg acgacccagg gcaacccgga cgcgctgaaa cccaggtcat
     2581 cgcggatgct gggcagggcc acgttcacga cggtgtcgtc gagcacgagc atgaactgga
     2641 cgaggcacag cacgatcatc ggcactcgat gacgctacga tccgccgcat ttggccacaa
     2701 tccgcgatga ggccagactg tgtcgcatgg aggacatggc cgcgatcatc gtcggccact
     2761 tcccgctggc ctcgggggag tggatacccc cgcacagcca cacccaccac cagctcgcct
     2821 ggacccggcg gggcgtcctg agcgtcggcg tggacgaggt gtactgggtc ctgccgccca
     2881 cccgggcgct gtggctgcct gcgggcgtca cccacacgac cggcgcgacc cgcgaagcgg
     2941 tgctgtgcag cctgtacctg gctccggagc gctgcccggt gaattgggtc gagcccacgg
     3001 cggtcggcgt cgacggcctg ctggccgagc tgatcgggta cctggcccgt accgacctca
     3061 ccgacgacgc gcggtcgcgc gccgaggcgc tggtgcccga cctgctgcgc ccgctgccca
     3121 cccggcccat cgacgtgccg caacccaccg acgagcgcgt ccgggcggtg gcggccgccc
     3181 tgctggcgga cccggcggac ccgcgcggcc tggaggcaca cgcccgcgcg gcgggcgtga
     3241 gccggcggac gttgacgcgg ctgttcgtgc acgacacggg catgagcttc gaccagtggc
     3301 gcacgcaggc acggctgcgc gccgccctgc cgctgctggc cgaggggcaa ccggtatcgc
     3361 gggtggcgca cagcgtgggg tacgccacgg cgagtgcgtt cctggcggcc ttccgccgca
     3421 cggtcggcac cacgccccgg cgctacctgc acagtcgttg actttgatct cctccacgct
     3481 gactggtacg cccctgacaa cgccttcacc caaccgacgc tgaggtccgc cggctaccgc
     3541 cagaacccgc cgccgcgcgt gcagagccgg ggacaactgt cggatctacg cgccaggcgc
     3601 agccgaccga ggctaggaag tcatgggcag gaagcgggtg tgcgcaggac gctgccagca
     3661 ccatgcactc gcgcgacggc acatcccggg ggccccgcgt ggggcgggtc gcgggacctg
     3721 ctgccagccc gtccgtcatg gtttcgcggt cccggcgcgg gggatgatcg gcgcagagca
     3781 gtggtgtgcc tgaccctgga ggacggcagc cctgacctga ggccgatgat ggcgtgcgcg
     3841 ccgcgaccgg cgactgcgca gccgtccctc ccgcggccga ccacgcctgg ccggcaaggc
     3901 caggcgtgcg cgtgacggcg aggaggggta atgccgcagc caggggaacc gcaggacgtg
     3961 ctggcgccgc ctgcggtggc ggcgatcttc ctggtggtga cagtacggcc gggcggcgag
     4021 gacgcggtgc gcggtctgct tcccgacatt gcagggctga cgcgcgctgt ggggttccga
     4081 tcgcccgaag gcggcctgag ttgcgtgacc gggatcggtg cggagttgtg ggaccggctg
     4141 tacgggccac cgcgcccggc cggcctgcat ccgttccggg tactcggcgg cgccgtccat
     4201 acggcggtgt ccaccccggg cgacctgctg ttccacctgc gggcgcgccg tatggacctg
     4261 tgctttgaac tggcgggcca gttgatgaac cgactcgccc ggtacgtcga cgtcgccgac
     4321 gaggtgcacg gtttccgcta cttcgacgaa cgcgacctga tggggttcgt cgacggcacc
     4381 gagagcccga aggggcgcga cggggtggtg gccgtgcgca tcggcgacga agatcccgcg
     4441 ttcgccggcg gcagctacgt ggtcgtccag aagtacgtcc acgacctcca ggagtgggac
     4501 gccctgccgg tcgaggcgca ggaactggcg atgggccgca cgaagctgaa cgacatcgaa
     4561 ctgcccgacg agatgaagcc gtcgaactcc cacgtggtcc tgaacacgat caccgatgcc
     4621 gacgggaacc agcggcagat cgtgcgggac aacatgccgt tcggcacggt cggcgcccga
     4681 gagttcggga cctatttcat cggctacacc gccagcgtcg aggtgatcga gcggatgctg
     4741 gagaacatgt tcatcggtga cccgccggga aaccacgacc gcattctgga cttctcgact
     4801 ccggtcaccg gtggcctgtt cttcgtgccc accgcggact tcctcgacga cccctcaccg
     4861 cagctggccg cggcggccgc cgcctcggcg gacaaacccg gacccgatgc gcaggctgca
     4921 gaggaaccag cagcgagggc gccgacttcg cccgatgacg gctcactcgg catcggcagc
     4981 ctgaaaggac acggcacctc atgaacaacc tgcaccgcga acttgctccg gtgtcggacg
     5041 ccgcctgggc cggcatcgag gacgaagtac gccgcacctt cacccgtcac gtcgccggac
     5101 gccgcgtggt ggacctggtc ggccccgccg gaaccgagtt gaacgcggtg gggaccgggc
     5161 acgtccgccc cttcgacgcg gcgaccgaag gggtgctgct ccaccggcgc gagacccagc
     5221 ccatcatcga ggtgcgtgtc cccttcaccg tcacccgcca ggccgtggac gatgtcgaac
     5281 gcggtgcgct cgactcggac tgggggcctg ccaaggacgc ggcgaagcgg gccgcgttcg
     5341 ccgaagacca cgcggtcttc cacggctccg acccggcctc gatcaccggc atcgtccccg
     5401 gcagctccaa cgccaccctg ccgctgcccc ccgacgtccg gcagtacccc ggcgccgtcg
     5461 ccaaggcgct gaccgcgctc cggctcgccg gtgtcaacgg gccctacagc ctgctgctgt
     5521 ccgccgacgc ctacaccgcg gtcaccgaga ccaccgacca cggctatccg atccaccatc
     5581 acctcgcgcg gctgctgcgc gacggtgaga tcatctgggc gccggcgctc gacggggccc
     5641 tgctgctgtc cacccgtggc ggcgactacg agcttcacct cggccaggac ctgtcgatcg
     5701 ggtacctgtc ccacaccgcc gaccgcgtcg atctctacct ccaggagtcg ctgaccttcc
     5761 tgtccatcac cgccgaatcc agtgtcccgc tgagcgccgg cggctagcgg ggcatgaccg
     5821 tctcgcaaga atcggatggg gagggccacg ccgttttcgt gggagcggtc tacgtgaacc
     5881 gatggtgggt cgcccgcgcc gacggcgcac ctgcgacccg ccacggcggg ctgatcccgg
     5941 agttcctcag tgaggaggga acaccgatgc gcgacgcagc ggtgaccttg gcgcgcgtgc
     6001 gagaggcgca gtggcggtga tgcacggtat tccttcgtcg ccgcgtgctc ggcggacagc
     6061 gtcggtgacc gccgggatcc tggtgtgcgt gctggtcggc gtgctggcga gcgtgccgct
     6121 gggagtgctc tcggggatcg ccgtcgcgat cgcggtgttc gtcacgacag gtgtggcgct
     6181 gctgtggccg atgaccgccg aggacacacg gcgcaacgcg cgccgggagg acttccagcc
     6241 gctcatggcc gagtcgctca tcgtgacggt cgcggtcgcc agcctggccg gggtcgcggt
     6301 gctgctggcg atcgggagtt ccgccacccg caacggcgcc gccgcgatcg gcctgttcgg
     6361 cgtcttcatg agctgggcga tgctgcacca gctgtacgcc atccgctacg cgcacctgta
     6421 ctacggcgag ccgtccgggg ggatcgactt caacagcgac gagcagcccg cctaccgtga
     6481 tttcctttat ttcagctaca acctcggaat gacctaccag gtgtcggaca ccgacgtatc
     6541 gagcacggtg atccgttcgg tggtgctgcg ccacacgctg ctgtcctacg tcttcggaac
     6601 ggtgatcctg gccgccacgg tcaacctggt catgggaatg atctcgagtt gagccgccgg
     6661 ggacgcggcg ggtcgacggt catcggctca ctcccggtcg ctagttctgt gtgggcagcc
     6721 aggcgccgtg cagccccagg ggcacgcgca cggggatgcg gacccgggcg accggcccgt
     6781 cggccgggtt ctggccgggc aggacgagga gccagctggt gaggtcggtg cggtcggtgg
     6841 cgaaggtgag ccagtagccg tcgccggcgt ccgtcgttcc ggggacgggg gcgaagacgg
     6901 gctcgccgac cgagagggcg cccgcgttcc aggtctcggc caccacgtcg tcgctgctca
     6961 cctcgtacca gcgcagcgcg tcgtactcgc cgggcagcag gtccggcgtc cgcccgcttc
     7021 cggccgcggt ggcgatccgg tggtgcgggc cggccaggac ccggtcgtcc acccggggga
     7081 attccacgcg cacgtcgtcg agcagccggc ggcggatgga gccggcgtcc gggtccagaa
     7141 cggcgcgggc gagcccgtgc ggggctccgc cgggagcggc cgggcgcgga cccagcccag
     7201 ggccgggcca ctggacgtag tccaggacga cctgtccgtc gggggtgtcg taggcgttga
     7261 cggtatgcca gacccagaac gcggtgtcgc gagcccaccg cacgggcccg ccgtcgcgcg
     7321 ggatcagcgc gatccgggtg ccgcgctcgg ggcgccagtc caggaacgaa ccaccctgca
     7381 acgccgccgc cagatccagg aaggcgggcg cgaggaccag gaccaggtag cggccggtga
     7441 gagccatgtc gtggatcatc accggctcct ccggaccctc caccgccgtg gggccccggt
     7501 cgaggctccc gtccgcaccg agcagtgacc aggtgaggaa cggttcctcc agcgcgtagc
     7561 agaagaccgc catctgcccg gtccgcgggt cgaccttggg gtgggcggtg atcccggcgg
     7621 gcaggccgtc gccgaaggtc tccctgccga gggtctccag ctccgggctc atccggtaag
     7681 ggcagtcgga ctcggcgagg gccagcagac gtccgccgtg ccgaacgatg ttgatgtccg
     7741 gcagctcctt gaacgtctgc gcgagcgcag gcccgacctc ctccgcccca gggatgatca
     7801 tcgactcgat tccgccccac aacgcacgcc ccgcggcctc ctccgcccgc agagcgggag
     7861 tgcgcacgaa acggttgcgg tagcgggcct tcccttggct catccacacg ccgtgcacca
     7921 tcccgtcgcc gtcgatggga aacaggtacg agccgatcgg cgtgaaccgc gggttggggc
     7981 cgttgcgcag gtagaccccg tccagatcgg cgggcagttc gccttcgacc tgcagttcgg
     8041 cctcgtccac ctcctcgctg acgggcgcga aggtcccgtt caggtgtgcg acgcgagtcg
     8101 gatcgaattc ggtggagtgc gcgaccatga ccaaccttcc gtccctggac ccggtggacg
     8161 cgcgccgtcg acgggccgga cgccctcacc acgggcagat gcgcagtgct cgccgcgcag
     8221 atggccgcac caacgccgcc cggcgcgggc cgctcgccgg tgctctcacc ggctcttacc
     8281 cgcccggcac gtcctcctca cgtcaagatc attcgaacgg tccgatctct cggagccgga
     8341 tgggtgtgat ggcgataaca gttgtcgttt tcgcttgtgg ggacacggtc tctcctgcgg
     8401 gcagacgctg cctgccgccg gcttgccggt gaagagacaa acgagaggtc atgggccatg
     8461 tccaatatga gggtaggtgg agacggcgcg cttcgagggg tcgccgtcgg cctcctcggg
     8521 ctgctgttct gcgttgccgg agacgccttc tccgcgctgg gtgccgaaga tcagttcccc
     8581 ttcgcgcccg gtgcgctcgg ggccgtcttc ggcgggctgt tcctcgcggg atacgccgtc
     8641 gtcaagatcg gtctgtcggt gcggtcgcgc ggtggcagcg ccgctgaaga gatccagcgg
     8701 gtgcgagcct cggccgggtc ggttcggtgg ccgatcgggt gcctggctgt ctccggggtc
     8761 ttctatctgc cgcttctggt cggtgcgacc cagcggatcg gcagcttcgc gacagtgatc
     8821 gcgatcgcgt tctgcggccc gctgggggtg gccgtctggg gcacgctccg caaggcccgc
     8881 tacgtcgcgg tgctctggcc cgtcctggcc ggcgtggggc tgtgggtcat gtcgctgcag
     8941 gaggagtccc gcatcgactg gctcggttac gccttcgcgg ccgtggcagc ggtctgcttc
     9001 gccgtgaacg tcagtgcggt ggagaagctg gaggaccggg gagccgagac gatcgggttg
     9061 gccctggccg gcctgctcac catcccaggt gcggcctgct ggctggtcgt ggggggcctg
     9121 gactggttcc agccccgggt cctcatgctg gccatgctga ccggtctgtg cacggcgtgc
     9181 gtggctccgg tactggaggc gcgctccatc ggctacctgg gcaaggagaa gttcggcgtc
     9241 ctgtccagcg gtgagccgat catgagcctg ccgatcgggc tgctgctgct cggggagact
     9301 cccgggtggt tcgtggccac cggcgtgctg atcatcgtgg tcgccatcgt ggccaacacc
     9361 accgacctgg acgagccgct gctccggtgg ctcggccgcc gggacctcgg ccggctgagg
     9421 gggtcgcgtc gactcgccaa ggcagcggtg cccgccgacg gcgcggcccg tacggccgac
     9481 agccagtcgc tggaggtcgc cgccgccctg tggccgctgg cccaaggcgg caacaccaag
     9541 gccgccgccc tgctgaccgg cgtcctcacg ccggtcgcgg aacgggccgg gctcacgaag
     9601 cggtgatccg ccgatagatg accgccggac tccccagggg gttcggcggt gcctgccgga
     9661 cggcgtgtga accgcgccgt ccgggccaag acgcgggctc aaccggcccg caaccgcggt
     9721 ggggaggcac agcctcccca ccgttctcgt cgccctgttc gtgatgctga acgaagaccg
     9781 ccgccctcgc gacgtccgca ggtcaagagc cgaacagagt gcgctcgaca tgctgggtgt
     9841 cggtgtactc ccggacggat gtgatccggc cgtcccgcac cgtgaagacg ccgaggcagg
     9901 cgttgtcgta ggcgctgccg ttgcgggccg ttccccggga cgtccattcg gccacgacct
     9961 ggtcgccgtc ggcgaccaca ttggtgagga cgaccctggg ctcgcccccg ggccggaaga
    10021 gctttccggc gtcgccgagg aagtcgccga tgatcgcgtc ccggccccgc caggtgccgg
    10081 tcagcggcag gtcaccgggg taggtccagg tggcctcgtc ggcgaagctc gcgctgatgg
    10141 tgtccaggtc gccgttcgcg accgcctcga cgtagcgggt gaccaccgac gccgggtcgt
    10201 ggctgagccg ggcggccagc cagtcgagcg tgtcgggcag ccatgcccag cggcggttct
    10261 ccaggaggtg gccgccctcg gggatcagcg tgtactcgcc gtcggccgcg cgcgcggcca
    10321 gctcttcgcc gttggcgacg cccgggatga cgtccagtcc gccgtccagg acgcggagcg
    10381 gctgcgggac ccggggcgcg gtgacccggc cggcgaaaag gcgcgcggcg tcctccccac
    10441 ccgtgcgcag gacgaacgac tccgtcacat acggcggaag ctcgtcccag gtgatggccg
    10501 tgggcccgct gacagagacg accgcgcgga tccgcggctc cttctccgcg gcgacggacg
    10561 cgaggaaccc gcccatgctg agcccgagca ggccgatgcc ggcgggcagg ccgtccacgg
    10621 cgtccagggc ctgccgcacc acccggtggt agtccgcctc ccaggtgccg cggacggcga
    10681 gttcgccctg ccccggcccg tcgatggcga ggacgccgag accgcgcgag agcagggcct
    10741 cggcgatcgg catgaactcg accttgccgg agttcatccc cggcaccagg acgaccaggg
    10801 gggcgtc
//
