LOCUS       NZ_BMRD01000003        23195 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence03, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000003
VERSION     NZ_BMRD01000003.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 632679)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 51448
            Orig. end                         :: 74643
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23195
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23195
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23195
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13195](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13195
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(83..1990)
                     /locus_tag="IEZ14_RS08120"
                     /old_locus_tag="GCM10010177_16470"
     CDS             complement(83..1990)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS08120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_16470"
                     /product="hypothetical protein"
                     /protein_id="WP_179837960.1"
                     /transl_table=11
                     /translation="MKSRKKGAEMVRARGGWWAAAALVTVLLLATLLGGGRVGLAVAAT
                     DGSAWLWSRTAGEVDRVNPDSGRVEQRREVRDARGHRVQVTQNDKFLLIHDLDTGRVSS
                     LDLNGLGFSGRLDIGTRGDPHLAMGSDGAALVERTSGAVRALDPATLRPVGPVLQLPGP
                     LVGGEFDDAGQLWVAVPRQGTVIAVKVTAQGPTVVRTAEAAPPDHDLTMTVLDEGALVV
                     DRGGRELVVAAGGETRRVTAPVSLAGAMVPARTHGALAAVTVPGAGSVVTLGDVRKGGP
                     VRSFPLTDPVQEPAVPFAGKVYLPVRETGQVRVFEPAGRQTGMLTMPAGRGDMELQVRE
                     GNLFVNAPGSTDALVVGGDGVARKVGKYPGGPGRGGERPDKPGGGASSPPPVPAPPGDP
                     VFPYPLDPRPSPKTPETPPSSRPGTPPPAGRTEAPRPPATPGSRTPSPRLPSRTPTTAP
                     TTKSPTRTTSPTSRPTTPRPTTPRPTTPRPSTPRPTTPRPTTPRPTTPKPTTPKPTPTK
                     PKPTQTSNPYTPAQVCNATAGGNYKVQRSSSFTGGRIYQLYSATTKKNCAVTMKTADIG
                     KGTNVWVRLQSQTGGKVASDNGTFKYYAGPVFVQAPGDCVRYSGGASGASASAGWANCG
                     "
     CDS             complement(2051..2200)
                     /gene="allorf_053499_053648"
                     /locus_tag="allorf_053499_053648"
                     /protein_id="allorf_053499_053648"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVARSPGLRTVICSVVPRCPVRRHRRRRRDPAVRRPVRQASLTWE
                     EDLP"
     CDS_motif       complement(2159..2200)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVARSPGLRTVICS"
                     /locus_tag="allorf_053499_053648_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(2051..2158)
                     /prepeptide="core"
                     /locus_tag="allorf_053499_053648_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.10"
                     /molecular_weight="4280.9"
                     /monoisotopic_mass="4278.4"
                     /core_sequence="VVPRCPVRRHRRRRRDPAVRRPVRQASLTWEEDLP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVARSPGLRTVICS"
                     /leader_location="[2158:2200](-)"
                     /alternative_weights="4298.9"
     gene            2332..2760
                     /locus_tag="IEZ14_RS08125"
     CDS             2332..2760
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015928.5"
                     /locus_tag="IEZ14_RS08125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase inhibitor family I36 protein"
                     /protein_id="WP_179837961.1"
                     /transl_table=11
                     /translation="MPSIRTTPAVLVLAAGTALVQAPSIASASTPSAPNTASPAALRSW
                     ADCPQGRMCIWRLPNAHGSRGSYAKVARDLSELGGGLNDHALSFWNRTGKTWCMYSDAR
                     FKGEGRKYPREPLAGAKGNTGQFGYKVSSLRPAFLGRC"
     gene            complement(2786..4231)
                     /locus_tag="IEZ14_RS08130"
                     /old_locus_tag="GCM10010177_16500"
     CDS             complement(2786..4231)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889919.1"
                     /locus_tag="IEZ14_RS08130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16500"
                     /product="MFS transporter"
                     /protein_id="WP_179837962.1"
                     /transl_table=11
                     /translation="MRLSQPSGRWAIAATALGAGLVLLETTVLNVALPAIARDLGTGMA
                     GMQWTVNAFALALAGLVLFGGALGDRYGRRRAYLAGLGLFALASLLGGLAPAIGWLIAA
                     RALQGVGGALLVPGSLALVQAAFHRDDRARAVGAWSGMSGMAGAAGPLLGGAVVDAAGW
                     RWVFWINVPVAVAVAAAVSRHVPETRDEGAVRGRLDVAGAALAAIGLAGVTYGLTDTSG
                     GGLLPEAAAVLGVLAMIAFVLVERRAEAPMLPPALLSHRRFGAANAASFCIYGAVAGMF
                     FLVPIQLQITSGYSPLAAGLALLPITVVVLVLSPHAGTLVTRFGPRAPLTVGAVVCTAA
                     ALLAVRIGPDASYLPDVLPAVVAAGLGISAITTPVSIAVLSAVPDSRAGIASAVNNAVA
                     RAAGLLVIAALPLLANLPEDATHSPRALGHGFTVGMVACAGLFLLGAAASWYGIGRPDA
                     PARSARHRHCALTTPMVEPPSNC"
     gene            4450..5373
                     /locus_tag="IEZ14_RS08135"
                     /old_locus_tag="GCM10010177_16510"
     CDS             4450..5373
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.5"
                     /locus_tag="IEZ14_RS08135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16510"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_179837963.1"
                     /transl_table=11
                     /translation="MTDLRQIEVFLALAEELHFGHTADRLHLTQPQVSRAVAALESHLG
                     GRLFERTSRQVRLTPLGRRFRHEAEPAYRLLTEALQNARARARDTAQPLRIGFFLSVGG
                     EPLSRLVRAHEARHPGIQISLTNVPYVDPYEPLRRDEVDVLISYLIVDPVEEPDLTTGP
                     AIHHTARVLVVAAGDPLAGRPSLSIEDLAGRRTVARPPRLPRALFDHFVPPATPLGEPI
                     HRTYDLGEGDAYGAAVAAVARGHIVHLSADIFTPLLAHRHDLDLIAIRDLPDIPIGLIW
                     VTARQNAAISALADTAASLSTATPRD"
     gene            complement(5465..6415)
                     /locus_tag="IEZ14_RS08140"
                     /old_locus_tag="GCM10010177_16520"
     CDS             complement(5465..6415)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013224.5"
                     /locus_tag="IEZ14_RS08140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16520"
                     /product="AsnC family transcriptional regulator"
                     /protein_id="WP_179837964.1"
                     /transl_table=11
                     /translation="MDSATLGQLDLQLLHALHLDGRAPFSRIAEVLGVSDRTAARRFAR
                     LRATGTARVTAVVDGRGAGHAEWLVRLRVPPPDAAGLARELARRSDTAWVTVLSSGTEI
                     AFIVRAPAGRAAPLAGLARHPRILGVEAYRLLRHLMEHRWLGRTSALTGEQVCALRPPP
                     GGAATPIALNDLDRRLLPVLAADGRAAYPRLAGHVGWSESAVRRRLEELRRSGTLRFDV
                     EVDPVLLGFPAQCLIWLTVTPSRLADTARALAADPEAAFVGAVTGPHNLLAIAVCRDED
                     ALYTYLSDRIGSLDGVERVETAPITSYVKRVAPPI"
     gene            6501..7376
                     /locus_tag="IEZ14_RS08145"
                     /old_locus_tag="GCM10010177_16530"
     CDS             6501..7376
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024859.5"
                     /locus_tag="IEZ14_RS08145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16530"
                     /product="VOC family protein"
                     /protein_id="WP_179837965.1"
                     /transl_table=11
                     /translation="MTHDIHGLHHTGIVVRDLGLLERTYISLGFTLSPRSRHLLNERPG
                     KPPVPGCTANRCALFGGAYIELLGIVDESAPDPWHTKAMVDQYEGFRLLNFDTDDAEAA
                     DRRLTGAGLRTSGVLDLERDVDTEEGTRTMRARAVHLDPRSTPEGYVGIAQHLTREYVH
                     QPRYLRHPNGARALEAVLIVVDDAGLDAVVSRYAAILQTSPVRRGHLTVVELAEGRLEL
                     VRASDAERALPGEPVPAASYPAAMTIAVDDLAAARTLVENGGTATRTVGGGFFVSARDA
                     GGAGLTFTAR"
     misc_feature    6516..6531
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.49"
                     /tool="antismash"
     gene            7373..8740
                     /locus_tag="IEZ14_RS08150"
                     /old_locus_tag="GCM10010177_16540"
     CDS             7373..8740
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012363.5"
                     /locus_tag="IEZ14_RS08150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16540"
                     /product="carboxylesterase/lipase family protein"
                     /protein_id="WP_179837966.1"
                     /transl_table=11
                     /translation="MIVEMAAGRVRGVSEGPLTAFRGIPYARADRFAAPGPVRPWPGVR
                     NASAPGPAAPQPASRLERVMGGFQAAQSEEKCLTLNVWAPPGDGHPVLVFLHGGGFTSG
                     SGGLDWYGGGELAAQGDLVVVTLNYRLGVLGFLRLPGLSEGNLGLLDQLAALRWVRDNV
                     AAFGGDPGKVTVAGQSAGAQSILALLSGGRAHGLFGRAILQSTPAGMLPDSPDEAERTG
                     ALLLDELGVEPGQAARLVDLPVSGLLAAHGAVARRTAAPLSAVPPFQLVADGDLVAADP
                     VAEVGRRAAGGVQLMMGTTRDEAAAFYALDDQVAALGPDELARIAAHWFGDPGRAAPEG
                     RTAARIAIDLATDQMFREPTLRLAESLTGNGAAPWLYRFDWHPPHSPYGACHCIDLPFV
                     LGTPGAWRDAPMLDGAPPAGLVREVRRHWTGFVRQGDPGWAAGTTHHFTDEPAGRT"
     CDS             complement(8806..8868)
                     /gene="allorf_060254_060316"
                     /locus_tag="allorf_060254_060316"
                     /protein_id="allorf_060254_060316"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGATVSAADTPWAAACRDRP"
     CDS_motif       complement(8845..8868)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGATVSAA"
                     /locus_tag="allorf_060254_060316_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8806..8844)
                     /prepeptide="core"
                     /locus_tag="allorf_060254_060316_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="1340.5"
                     /monoisotopic_mass="1339.6"
                     /core_sequence="DTPWAAACRDRP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGATVSAA"
                     /leader_location="[8844:8868](-)"
     misc_feature    9126..9139
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: strong, score: 23.28"
                     /tool="antismash"
     misc_feature    complement(9127..9140)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.37"
                     /tool="antismash"
     gene            9239..9610
                     /locus_tag="IEZ14_RS08155"
                     /old_locus_tag="GCM10010177_16550"
     CDS             9239..9610
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039929.4"
                     /locus_tag="IEZ14_RS08155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16550"
                     /product="DurN family substrate-assisted peptide maturase"
                     /protein_id="WP_179837967.1"
                     /transl_table=11
                     /translation="MRSGPKPPSDLTKHKGIETVRQIQFLMVLCSVLPPDGKAREMLRL
                     ALDVSNEEFPDGVEPIHDLHPQATKTWLEFFWTRVGISPEERELIDWQNDKPSMDIAVE
                     ELQEAERRLGIRLAPRTVE"
     gene            9635..9874
                     /locus_tag="IEZ14_RS08160"
                     /old_locus_tag="GCM10010177_16560"
     CDS             9635..9874
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_089310450.1"
                     /locus_tag="IEZ14_RS08160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16560"
                     /product="cinnamycin family lantibiotic"
                     /protein_id="WP_089310450.1"
                     /transl_table=11
                     /translation="MSPSTILRHAAADADVRTELLAGAGRFGVPAAAVPAAVAQPDTAS
                     LGYWTEGVAAVDAYACASTCSSGPFTFACDGSTK"
     CDS_motif       9635..9706
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSPSTILRHAAADADVRTELLAGA"
                     /locus_tag="IEZ14_RS08160_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9707..9874
                     /prepeptide="core"
                     /locus_tag="IEZ14_RS08160_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="5192.7"
                     /monoisotopic_mass="5189.5"
                     /core_sequence="GRFGVPAAAVPAAVAQPDTASLGYWTEGVAAVDAYACASTCSS
                     GPFTFACDGSTK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSPSTILRHAAADADVRTELLAGA"
                     /leader_location="[9634:9706](+)"
                     /alternative_weights="5210.7"
                     /alternative_weights="5228.7"
                     /alternative_weights="5246.7"
                     /alternative_weights="5264.8"
                     /alternative_weights="5282.8"
                     /alternative_weights="5300.8"
                     /alternative_weights="5318.8"
     gene            10001..13195
                     /locus_tag="IEZ14_RS08165"
                     /old_locus_tag="GCM10010177_16570"
     CDS             10001..13195
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="IEZ14_RS08165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16570"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_179837968.1"
                     /sec_met_domain="DUF4135 (E-value: 9.6e-70, bitscore:
                     230.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.8e-58, bitscore:
                     192.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPTFPVDLAARAANLSERIQIVSALGPPSGAEPLEAFDAWRIDR
                     LAAKLAAKFGAETSPRSERHTEESLRETLRAYRAHELGLTDPEGRLGRMLADLHRGWLP
                     VYRETLDGFDPGDEAFAAADWRSDEVYHGRLATACEPFLVELGRRLTSAIDGGGPAVRV
                     DSRLVADFQAYLLDRFELALAWAVETDAKVHCRLHGIDPASATHDDYLAYLDKTFADTD
                     AYHRFYLEFPLLGRWLAQTTGQLAEHGAQMVGRLRDDAAELSESFFGRPVAAVRTARLG
                     RSDHHAGGRSVAIVEVELADGAQESVVYKPRGLEGEAGFQGLLARLRADGVLDYAERAV
                     LRRDGYGFEALIPPGRNRVATREEAERVYAELGGYLAIFYVLGGGDLHFENVLIADGHA
                     FICDCETVLGALPKGWPRPSGTLMDSVFRTGLIEWPRSGAAPEGEMRISGYTGGGGYEM
                     PMPVPQVDRLQSFASSVSYREGVRVDPGAANRIFVGEELTHAEEFVDAIGTGFDRVYEW
                     FRRRPDEAIACVRELFSGSGVRFVNWSTQVYSQLLAAALHPRCLLEPLEADLLIETVRT
                     FPRKWDQDAALPGWEVASMWRRDVPLFSVEAGGTALVHDHVSRVGADLETSPLDHAASR
                     IRGLSARNRAQQRQYIAAGLSGGDVTSADFAETCVERAAALGEQLCAMLRAPDAPAPWT
                     SFVIAPDGRNEVDIEGDLYNGSGGIALFLAYLDALDPRPEFRAAARRALDHAVATWERQ
                     RIGAFTGLGGMVYVLTHLYRLWGERALLDRALELGDELAGRIDGDRHLDVFHGAAGLIP
                     VMIGLAGVADGRGLEQAHHCAAHLLCRAEAEGDALSWPGSDLGASGANLTGLSHGAGGV
                     GWALITLGRLTDRAEYVSAGRRAFAYEALHFDQSAQDWYDLREFPGGMLWEGRHYANAW
                     CNGAAGIGLSRIQSWAALGKDDDSVLTEARSALTATMRNFPRLMNDSLCHGRSGNAELF
                     LRFALLADEPAFRLEANVQVQAQWRNLEDAPPASATGFFPGLMLGMSGFGMHFLRLAHP
                     ERVPSALLLDPPPASI"
     misc_feature    complement(10047..10061)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            13211..14119
                     /locus_tag="IEZ14_RS08170"
                     /old_locus_tag="GCM10010177_16580"
     CDS             13211..14119
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03798"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631330.1"
                     /locus_tag="IEZ14_RS08170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16580"
                     /product="Nif11-like leader peptide family natural product
                     precursor"
                     /protein_id="WP_179837969.1"
                     /sec_met_domain="TIGR03798 (E-value: 2.3e-09, bitscore:
                     32.6, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVESCAAFLRYALRDTGIRQQMKAMTAVAEMIRLGRAHGYLFDA
                     RDLAAASSSPDFSEAAPRAASEKAASGPQAPAPATAEPTAFYHYEYDMADLPGFDAVLE
                     QLPALKIKPSTVDLAEFDAEFRADDLRSTSLAPNGAEYHRWRAAPATRRRRDFHLVNLD
                     SHTDHADYEAYYAAKIRLVDALEKVFGGEVRLSGNLWYPPSSYRLWHTNEDQPGWRMYL
                     IDFDEGFPDAEHTSFFRYQHPETDELVTLRERPKLARFFKVEQDPDRLFWHCIVNPTPR
                     HRWSFGCHVPDTWLGAIAGRS"
     gene            14116..15963
                     /locus_tag="IEZ14_RS42660"
                     /old_locus_tag="GCM10010177_16590"
     CDS             14116..15963
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.5"
                     /locus_tag="IEZ14_RS42660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16590"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_308427175.1"
                     /transl_table=11
                     /translation="MTARPATAAPAGPGAVAPAGATPAIRAVGLRKRYPGVEAVAGLDL
                     TIPPGESFGFLGPNGAGKTTTIAMLCTLAVPTSGRIEIAGHDTRTDSAAARRRIGLIFQ
                     ESTLDVQLTAAENLRFHADLYNVPSGQVEARVEETLALVGLTGCRDRVVHTFSGGMRRR
                     LEIARALLHRPQILFLDEPTIGLDPNARAQVWRHLRHVCETESVTLFLTTHHLEEAEQC
                     DRIAIIDAGRIVAQGSPAELKSVLGADRVELRTGDDATAAQLIAERLGLEVTRDRHGLR
                     FQVPEGARVLPRLLTELDVPVYEARVTPPSLDDVFLHHTGHRIRDEAPPEPSACPMRVP
                     SASEPGKGGLRAELRAMGMVWRREMLHFRRDRVGAAISLVQPLIFLFILGIGLSNLMPG
                     PNGDAYQLFLFSGALVTAAQGPALATGTSIMWDRQGGFLREMLAGPVSRASLLIGKCLG
                     GTTVATCQAAILLATAAPVGVPLDGVLIALLLGELVLVSLAMTVLSVLLSTILRRPQTF
                     GTVLTVIMAPMVFLSGAFFPLSAMPVWMKALALANPLTYAVDVMRRTITAYLPDAPHHL
                     FQPLALGSWHPPLLLECALMAALTTAALSYAAHRFTRLP"
     gene            complement(16002..16289)
                     /locus_tag="IEZ14_RS08185"
                     /old_locus_tag="GCM10010177_16600"
     CDS             complement(16002..16289)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017571773.1"
                     /locus_tag="IEZ14_RS08185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16600"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_229810083.1"
                     /transl_table=11
                     /translation="MGRAAEMLGVTPAFLRSLDTSRLIVPQRSSGGHRRYSRYQLRLAQ
                     RARDLVDQGTALEAACRIIILEDQLAEAQRINARLRQDRSEGGTSRPPGQ"
     misc_feature    16287..16304
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    complement(16315..16330)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.38"
                     /tool="antismash"
     CDS             16415..16531
                     /gene="allorf_067863_067979"
                     /locus_tag="allorf_067863_067979"
                     /protein_id="allorf_067863_067979"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLSQNLPYCRGIGRRRRQGAPAPYCGAGAQRYNTTYRL"
     CDS_motif       16415..16474
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLSQNLPYCRGIGRRRRQGA"
                     /locus_tag="allorf_067863_067979_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       16475..16531
                     /prepeptide="core"
                     /locus_tag="allorf_067863_067979_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.20"
                     /molecular_weight="1966.2"
                     /monoisotopic_mass="1965.0"
                     /core_sequence="PAPYCGAGAQRYNTTYRL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLSQNLPYCRGIGRRRRQGA"
                     /leader_location="[16414:16474](+)"
                     /alternative_weights="1984.2"
     misc_feature    complement(16421..16430)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.21"
                     /tool="antismash"
     gene            complement(17112..17399)
                     /locus_tag="IEZ14_RS08190"
                     /old_locus_tag="GCM10010177_16610"
     CDS             complement(17112..17399)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS08190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_16610"
                     /product="hypothetical protein"
                     /protein_id="WP_179837970.1"
                     /transl_table=11
                     /translation="MSEVWISAAEGDDLIRADAIVILRMDRTGRLTVQLRDEAKVSVTL
                     LEGTPGGTRPPADFHRQLIRLVAELADSSGTQLVRARHENGAWRWTSESL"
     CDS             complement(17614..17844)
                     /gene="allorf_069062_069292"
                     /locus_tag="allorf_069062_069292"
                     /protein_id="allorf_069062_069292"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MHLGLRSGVCVWPGPLKDPWTPHRGPGGRQGRRRERASAFERDGG
                     AASCAPACLASGRPIIGNQGDAGLAARIENP"
     CDS_motif       complement(17701..17844)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MHLGLRSGVCVWPGPLKDPWTPHRGPGGRQGRRRERASAFERDGGAAS"
                     /locus_tag="allorf_069062_069292_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17614..17700)
                     /prepeptide="core"
                     /locus_tag="allorf_069062_069292_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.10"
                     /molecular_weight="2718.1"
                     /monoisotopic_mass="2716.4"
                     /core_sequence="CAPACLASGRPIIGNQGDAGLAARIENP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MHLGLRSGVCVWPGPLKDPWTPHRGPGGRQGRRRERASAFE
                     RDGGAAS"
                     /leader_location="[17700:17844](-)"
     gene            17839..18210
                     /locus_tag="IEZ14_RS08195"
                     /old_locus_tag="GCM10010177_16620"
     CDS             17839..18210
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.5"
                     /locus_tag="IEZ14_RS08195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16620"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_179837971.1"
                     /transl_table=11
                     /translation="MHTAGTASPEAGLRREALTEHTVITITGDLDIASAPSLRGPLETA
                     LRDAGPLVVIDLSEVTFCDAAGLALLTGARRVAEPEGVTLVLAAPRPHMVRLLRVSGLA
                     RVFAVRPTVDAAHIRSAAA"
     gene            18255..18848
                     /locus_tag="IEZ14_RS08200"
                     /old_locus_tag="GCM10010177_16630"
     CDS             18255..18848
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024883.5"
                     /locus_tag="IEZ14_RS08200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16630"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_179837972.1"
                     /transl_table=11
                     /translation="MTGDPGSIGWGAAGAAPSDADRRRLAATFELMSAVVLEGTDVPGM
                     LALVAAHARELAHVPLAFVALPGEDGNTLRVEVADGPGGDRIRGLTVRRGRSMLGRAFT
                     SRRAVSARIAADQTLTGLPAGPILILPLETGEATRGVLAVLGRVGAEPFGPATARQMLL
                     FSDMAARLIEVAGARHPGASPGVAESTLRPQSSG"
     gene            complement(18975..19202)
                     /locus_tag="IEZ14_RS08205"
                     /old_locus_tag="GCM10010177_16640"
     CDS             complement(18975..19202)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629771.1"
                     /locus_tag="IEZ14_RS08205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16640"
                     /product="hypothetical protein"
                     /protein_id="WP_179837973.1"
                     /transl_table=11
                     /translation="MKPTGPARRRHLPTSPFKPPPAAPPAKEFTLDDQVTHDKYGLGRV
                     LEVEPGNAVLVDFGTRKVKILSPFTKLFRL"
     misc_feature    complement(19373..19386)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    19383..19397
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.19"
                     /tool="antismash"
     gene            19469..19672
                     /locus_tag="IEZ14_RS08210"
                     /old_locus_tag="GCM10010177_16650"
     CDS             19469..19672
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119326.1"
                     /locus_tag="IEZ14_RS08210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16650"
                     /product="cold-shock protein"
                     /protein_id="WP_179837974.1"
                     /transl_table=11
                     /translation="MATGTVKWFNAEKGFGFIEQDGGGADVFAHYSNIAAQGFRELQEG
                     QKVTFDITQGQKGLQAENIVPA"
     gene            19892..21316
                     /locus_tag="IEZ14_RS08215"
                     /old_locus_tag="GCM10010177_16660"
     CDS             19892..21316
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634785.1"
                     /locus_tag="IEZ14_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_16660"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_179837975.1"
                     /transl_table=11
                     /translation="MPRAPRSSGRGSRPRPARRPADGRRPDAKATPPAAVQATPAAPAV
                     ASFAELPLPAPLLDTLGRQGVTAPFPIQAAALPNALAGRDVLGRGRTGSGKTLTFGLAL
                     LARTAGHRAQPRRPLALVLVPTRELAQQVTGALEPYADAVDLRMTTVVGGLPIARQANA
                     LARGVDVLIATPGRLADLIERGDCRLGDVRITVLDEADQMTDLGFLPQVTRLLEQTPPD
                     GQRMLFSATLDGGVDRLVRRFLSDPVTHSVDPPAGAVTAMEHHLLHVTDTDKHETTVHI
                     AARESRVIMFVGKKHAADRLVRKLTARGISAAAMHGGKTQSQRNRALDGFHRKDVTVLV
                     ATNVAARGIHIDELDLVVNVDPPADHKDYLHRGGRTARAGNAGTVVTLVLPEQRREMDD
                     MMAKAGITPRSARVRPGDADLARITGARPPARAAAAPNTAPARKPRPAASGSQRGNSHA
                     AAPSRRPRRRASSLNS"
     gene            complement(21351..22349)
                     /locus_tag="IEZ14_RS08220"
                     /old_locus_tag="GCM10010177_16670"
     CDS             complement(21351..22349)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEZ14_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010177_16670"
                     /product="hypothetical protein"
                     /protein_id="WP_179837976.1"
                     /transl_table=11
                     /translation="MVSDDDAIDYADVARELASMLHGYPNGDPYELLGWIAAEVRSGPG
                     TRAGRAMTAALWASRWYVKWQVTDPALVDDLIEAAGRAGTVLEAAGCTAPGEHEHPQVD
                     DDPEAMGDVVARIGDPEKWFATDPDRDPDDEDVEAYACPGFLAELAAEAEEALRDARAE
                     RFEARDTAHLDEHFLTGEGRTDLDAVMTDIELQKYSSIDPTAESAALWAARRLLGDARP
                     GERVSLALAVSYLAQRCAGGAAAPGVVALYREGLQTFDLSALDRPCPHPEAHPRIKLRD
                     LPRLARAMAPDSAPVDDREGCPRRIAAHVREIIDYTGGYLGVEDAPAEVSA"
     misc_feature    22790..22806
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
ORIGIN
        1 gctcgaaggc ggcggcggcc agcagcgcct cctcgtcagg cagcgcggac gtcgcggtcg
       61 tggtgctcac tcattaccct tcttagccgc agttggccca gccggccgag gcgctggcgc
      121 cggacgcgcc gcccgagtac cggacgcagt cgcccggcgc ctggacgaag accggtccgg
      181 cgtagtactt gaacgtgccg ttgtcggagg cgaccttgcc gcccgtctgg ctctggaggc
      241 ggacccagac gttggtgccc ttgccgatgt ccgcggtctt catcgtgacc gcgcagttct
      301 tcttggtggt ggcgctgtag agctggtaga tccgcccgcc cgtgaacgac gacgaccgct
      361 ggaccttgta gttgccgccc gcggtcgcgt tgcagacctg cgccggtgtg tacgggttgc
      421 tggtctgagt gggcttcggc ttggtcgggg tgggcttggg cgtggtcggc ttcggcgtgg
      481 tcggcctggg cgtggtcggc ctgggcgtcg tcggcctagg cgtggagggc ctgggcgtcg
      541 tcggcctggg cgtggtcggc ctgggcgtcg tcggccggct cgtgggcgac gtggtcctgg
      601 tgggcgactt cgtcgtgggg gccgtcgtgg gcgtccgtga gggcagccga ggcgacgggg
      661 tgcgcgagcc gggcgtcgcc ggaggccgag gcgcttccgt acggccggcc ggagggggcg
      721 ttccgggtct gctggacggt ggcgtctcgg gggtcttggg agagggcctc gggtcgagcg
      781 ggtacgggaa gaccggatcg ccgggcggtg ccggtaccgg aggcgggctg ctcgccccgc
      841 cgcccggctt gtccgggcgc tctccgcccc gccccggccc gcccgggtac ttgccgacct
      901 tgcgggccac tccgtcaccg ccgacgacca gggcgtccgt gctgcccggc gcgttgacga
      961 acaggttgcc ctcgcggacc tggagctcca tgtctccgcg ccccgccggc atggtcagca
     1021 tgccggtctg ccgccccgcc ggctcgaaga cccggacctg cccggtctcc cgcacgggca
     1081 ggtacacctt gccggcgaac ggcacggcgg gctcctggac gggatcggtc agggggaacg
     1141 accggaccgg gccgcccttg cgcacgtcgc ccagcgtgac caccgagccc gcgccgggga
     1201 ccgtgaccgc ggccagcgcg ccgtgggtgc gcgccggcac catcgcgccg gcgagcgaca
     1261 ccggggccgt gacccggcgg gtctccccgc ccgccgcgac caccagctcg cgcccgccgc
     1321 ggtcgaccac gagcgcgccc tcgtccagca cggtcatcgt cagatcgtgg tcgggcgggg
     1381 cggcctcggc cgtacggacg acggtggggc cctgggcggt gaccttcacg gcgatgacgg
     1441 tgccctgccg gggcacggcc acccagagct ggccggcgtc gtcgaactcg ccgccgacca
     1501 gcggtccggg cagttgcagg accgggccca cggggcgcag cgtggccgga tccagcgcgc
     1561 gcaccgcgcc ggacgtgcgc tcgaccagcg cggccccgtc ggagcccatc gccaggtgcg
     1621 gatcacctcg ggtgccgatg tccagccgtc ccgagaagcc caggccgttc aggtctagcg
     1681 acgacacgcg accggtgtcc aggtcgtgga tgagcaggaa cttgtcgttc tgggtgacct
     1741 gcacccggtg gccgcgggcg tccctcacct cgcggcgctg ctccacccgt ccgctgtcgg
     1801 ggttgacccg gtccacctcg cccgccgtcc ggctccacag ccaggcgctg ccgtcggtgg
     1861 ccgcgacggc gagaccgacc cgccccccgc cgagcagcgt ggccagcagc aagacggtga
     1921 ccagcgcggc cgcggcccac cagccgcctc gcgcgcgaac catctcggcg cccttcttcc
     1981 gcgacttcac ggccgctcct tcatcccatg gcctcgcggt gcgggctcgc cccgctcatg
     2041 tcgacggcca tcagggcagg tcttcttccc aggtcaacga tgcttgtcga accggccggc
     2101 ggacggccgg gtctcgacgg cgtcggcgat gccgccgaac agggcaccgc ggcaccacgc
     2161 tacagatcac cgtccggagt ccgggcgatc ttgcaaccac cggaccccgt cgcgcggagg
     2221 aggcggacgc gttcagcggc tggaagcccc agcgcgggcg gggttacact gcgaaccgac
     2281 tacggaaagt aatcaactcg atacgaagag agcatgggag gcagatcgca gatgccgtcg
     2341 atccgaacga ccccggccgt cctggtcctg gccgccggga ccgcgctcgt ccaggccccg
     2401 tccatcgcct cggcgagcac gcccagcgcc ccgaacaccg cgtcgccggc ggcccttcgc
     2461 tcctgggccg actgccccca gggccggatg tgcatctggc gcctccccaa cgcccacggc
     2521 tcgcggggct cctatgccaa ggtcgcgcgc gacctcagtg agctcggcgg cggcctcaac
     2581 gaccacgccc tgtccttctg gaaccgcacc ggcaagacct ggtgcatgta ctccgacgcc
     2641 cgtttcaagg gcgaaggccg caagtacccc cgcgaaccgc tggcgggcgc caagggcaac
     2701 accggccagt tcggctacaa ggtcagctcg ctccggcccg ccttcctcgg ccgctgctga
     2761 caggcgctgc tcgtcccgcc cagagctagc agttagaggg cggttccacc atcggtgtgg
     2821 tgagagcgca gtgccgatgg cgggccgacc gggcgggcgc gtcggggcgg ccgatcccgt
     2881 accaggacgc ggcggcgccg aggaggaaga gcccggcgca cgcgaccatg cccacggtga
     2941 acccgtggcc gagggcccgc ggactgtggg tggcgtcctc gggcaggttc gccagcagcg
     3001 gcagcgcggc gatgaccagg aggcccgcgg cgcgggcgac cgcgttgttg accgcgctgg
     3061 cgatgccggc gcggctgtcg gggacggcgg acagcaccgc gatgctgacg ggagtggtga
     3121 tcgccgagat gcccaggccg gcggcgacga cggccggcag gacgtcgggc aggtaggagg
     3181 cgtccgggcc gatgcgcacc gccagcaacg ccgctgccgt gcagacgacc gcgccgacgg
     3241 tgagcggcgc ccgcgggccg aaacgggtga cgagggtgcc cgcgtggggt gacagcacga
     3301 gcacgacgac ggtgatcggc agcaacgcca gcccggcggc gagcggggag tagccgctgg
     3361 tgatctgcag ttggatcggc acgaggaaga acatcccggc caccgcgccg tagatgcaga
     3421 acgaagccgc gttcgccgcg ccgaaccgcc ggtgcgacaa cagggccggc ggcagcatcg
     3481 gcgcctcggc gcgccgctcg accagcacga aagcgatcat tgcgagaacg ccgagcacgg
     3541 cggcggcctc gggaaggagc ccgccgcccg aggtgtcggt gaggccgtag gtgacgccgg
     3601 cgaggccgat cgccgccagc gcggcaccgg ccacgtccag acggccgcgc accgccccct
     3661 cgtctcgcgt ctcgggtacg tggcggctca cggccgccgc caccgcgacg gcgaccggga
     3721 cgttgatcca gaacacccac cgccagcccg ccgcatcgac cacggcgccg ccgagcagcg
     3781 gcccggccgc cccggccatc ccgctcatgc ccgaccacgc gccgaccgcc cgcgcccggt
     3841 catcgcggtg gaaggccgcc tggacgagtg ccagcgaccc gggaacgagc agcgcaccgc
     3901 cgacgccctg cagcgcccgc gcggcgatca gccagccgat ggccggggcc agcccgccca
     3961 gcagcgaggc gagcgcgaac agaccgaggc cggccaggta ggcccgccgc cgcccgtagc
     4021 ggtccccgag cgcgccgccg aagaggacca gaccggccaa cgccagcgcg aacgcgttca
     4081 ccgtccactg catgccggcc atgccggtgc ccaggtcgcg cgcgatcgcg ggcagcgcga
     4141 cattgagcac cgtcgtctcc agcagcacca gccccgcccc gagcgcggtc gccgcgatcg
     4201 cccaccggcc ggaaggctgc gacagccgca actcaccccc gatatcgatc gttctcccac
     4261 ccgtcatatc cgatgtgccg gtggccgtca tccggatccc ttcgggccgc gccggccatc
     4321 gactcgtccg cgccggcatg gggtttccac gagcgtgatc gatggcgggt tcgaccatca
     4381 acaccgatat atgcaacgat cgatgtcgtc accgcatgga tcgtggccga ctctgcccgg
     4441 aggcatcgat tgacggacct gcggcagata gaagtgttct tggcgctggc cgaggagctg
     4501 catttcggcc ataccgccga ccggctccat ctcacccagc cgcaggtgag ccgggccgtc
     4561 gccgccctgg aaagccatct gggcggccga ttgttcgaac gcaccagccg ccaggtccgc
     4621 ctcacgcctt tgggccgccg atttcgccat gaggccgagc ccgcttaccg tcttctgacg
     4681 gaggccctgc agaatgctcg cgcccgagcc cgtgacacgg cgcagccgct ccgcattggt
     4741 ttctttctct ccgttggcgg ggagccgctc agccgcctgg tccgcgcgca tgaggcccgc
     4801 caccccggaa tccagatatc cctgacgaac gtcccgtacg tcgatcccta cgaaccgctc
     4861 cgccgcgacg aggtcgacgt cctgatctcc tatctcatcg tcgaccccgt cgaagaaccc
     4921 gacctgacca cgggcccggc gatccatcac accgcccggg tcctggtcgt cgcggccggc
     4981 gacccactgg cgggcaggcc gtcgctgtcg atcgaagacc tcgcgggccg caggaccgtg
     5041 gcacgaccgc cccggctccc ccgcgctctc ttcgaccact tcgtgccgcc cgcgaccccc
     5101 ttgggcgaac cgatccaccg cacctacgac ctcggtgaag gcgacgccta cggcgcggcg
     5161 gtggccgcgg tcgcgcgcgg ccacatcgtc cacctgagcg ccgacatctt cacccccctc
     5221 ctggcccacc gccacgacct cgacctcatc gccatccgcg atctgcccga tatcccgatc
     5281 ggcctcatct gggtcaccgc ccgccagaac gccgccatca gcgccctcgc cgacaccgcc
     5341 gcgagcctct ccacggccac tccgcgcgac tgatccggaa gggccgcgcg gggacgcgcg
     5401 ccgtgacgac acatcagggg ttttcgagtc ccggggcgcc cgggttcccc cggcgcaggg
     5461 ggcctcagat gggcggggcg acgcgtttga cgtaagaggt gatcggagcg gtttccacgc
     5521 gttcgacgcc gtccagagat ccgatccggt cactgaggta ggtgtacagg gcgtcctcgt
     5581 cccggcagac ggcgatggcc aggagattgt gcggaccggt gaccgcgccg acgaaggccg
     5641 cctcagggtc ggcggccagc gctcgggcgg tgtcggcgag ccgggacgga gtgacggtca
     5701 gccagatcag gcactgggcc gggaaaccca gcagcacggg gtcgacctcg acatcgaagc
     5761 ggagcgtgcc ggagcggcgc agttcctcca gccgccggcg gaccgccgac tccgaccagc
     5821 cgacgtggcc ggccagtctc ggataggcgg cgcggccgtc ggcggccagg acggggagca
     5881 gccggcggtc gagatcgttc agggcgatcg gggtggcggc gccgccgggc ggcggacgga
     5941 gcgcgcagac ctgctcgccg gtgagcgccg acgtccggcc gagccagcgg tgctccatca
     6001 ggtggcgcag cagccggtac gcctccacgc cgaggatgcg cgggtggcgg gccagccccg
     6061 ccagcggggc tgcgcgtccg gcgggagcac ggacgatgaa ggcgatctcg gttccgctcg
     6121 acagcacggt cacccaggcg gtgtcggagc gccgcgccag ttcccgggcc aggccggcgg
     6181 cgtcgggggg cggcacgcgg agccggacga gccactcggc gtggccggcg ccgcggccgt
     6241 cgacgacggc cgtcacccgg gccgtgccgg tggcgcgcag ccgtgcgaaa cggcgggcgg
     6301 ccgtgcggtc ggagacgccg aggacctcgg cgatccggct gaacggggcg cgcccgtcga
     6361 gatggagcgc atgcagcaac tgcaggtcga gctgcccgag cgtggccgaa tccaccagaa
     6421 gatcgtacgt cggtgtcgga tcacggcgtt cggggtgctc tccggtgacg tggcccggac
     6481 gggtgccgca gcatcggcgc atgacccacg acatccatgg tctccaccac accggcatcg
     6541 tcgtccgcga tctcggcttg ctggagcgca cctacatctc gctcggcttc accctgagcc
     6601 cccgctcccg gcacctgctg aacgagcgcc ccgggaagcc accggttccc ggctgcaccg
     6661 ccaaccggtg cgccctcttc ggcggggcct acatcgaact gctgggcatc gtggacgaat
     6721 ccgcgcccga cccctggcat accaaggcga tggtcgacca gtacgagggg ttccggctgc
     6781 tcaacttcga caccgacgac gcggaggcgg cggaccggcg gctgaccggc gccgggctgc
     6841 gcacctccgg cgtcctggac ctggaacgcg acgtcgacac cgaggagggg acccgcacca
     6901 tgcgcgcccg cgccgtgcac ctcgacccgc gttcgacgcc cgagggctac gtcggaatcg
     6961 cccagcacct cacccgcgag tacgtgcacc agccgcgcta cctgcgccac cccaacggcg
     7021 cgcgggctct ggaggcggta ctgatcgtgg tcgacgacgc cggtctcgac gcggtcgtgt
     7081 cccggtacgc cgccatcctg cagacctcgc ccgtgcgacg ggggcatctc acggtggtgg
     7141 agctggcgga gggccgcctc gaactcgtcc gcgcctcgga cgcggaacgg gcactgcccg
     7201 gagagcccgt cccggccgcg tcctatccgg ccgccatgac catcgcggtc gacgacctcg
     7261 ccgccgcgcg cacgctcgtc gagaacggcg ggaccgccac ccgaacggtc ggcggcgggt
     7321 tcttcgtctc cgcccgggac gccggcggcg cgggcttgac cttcaccgcc cgatgatcgt
     7381 cgaaatggcc gcgggccggg tgcgcggcgt ctccgagggg ccgctcaccg cgttccgcgg
     7441 cattccctac gcccgtgccg accgcttcgc cgcacccggg ccggtgcggc cctggcccgg
     7501 ggtgcggaac gcctccgcac cgggtccggc cgccccgcaa cccgcgtccc gcctcgaacg
     7561 cgtgatgggc ggcttccagg ccgcccagtc ggaggagaag tgcctgacac tgaacgtgtg
     7621 ggcgcctccc ggcgatggcc atccggtgct cgtcttcctg cacggcggcg gcttcaccag
     7681 cggctcgggc gggctggact ggtacggcgg gggggaactg gccgctcagg gagacctggt
     7741 ggtcgtgacc ctcaactacc gcttgggcgt gctcggcttc ctgcgcctcc ccgggctgag
     7801 cgaggggaac ctgggactgc tcgaccagct cgccgcgctc cgctgggtac gcgacaacgt
     7861 cgccgccttc ggcggtgatc caggcaaggt gacggtggcc ggccagtcgg cgggcgccca
     7921 gtcgatcctg gcgctgctgt ccggtggtcg tgcccacggg ctgttcgggc gcgcgatcct
     7981 gcagagcacg cccgcgggca tgctccccga ttcgccggac gaggccgaac ggaccggtgc
     8041 cctcctgctg gacgaactcg gcgtcgaacc cggacaggcc gcacggctcg tggacctccc
     8101 cgtctccggc ctgctggccg cccacggcgc cgtggcccgc cgcaccgccg caccgctcag
     8161 tgccgtgccg ccgttccagc tcgtcgccga cggcgacctg gtggcggccg acccggtggc
     8221 agaggtcggc cggcgcgccg cgggcggcgt ccagctgatg atgggcacca cgcgcgatga
     8281 ggcggcggcg ttctacgccc tcgacgacca ggtggcggcg ctcggtcccg acgaactcgc
     8341 gcgcatcgcc gcccactggt tcggcgaccc cggccgcgcg gcgccggaag gccggacggc
     8401 cgcccggatc gccatcgacc tcgccaccga ccagatgttc cgtgaaccca cgctccgcct
     8461 ggcggagtca ctcaccggca acggcgccgc gccctggctc taccgcttcg actggcaccc
     8521 accgcacagc ccctacggcg cgtgccactg catcgacctg cctttcgtcc tcggcacccc
     8581 gggtgcctgg cgtgacgcgc ccatgctcga cggcgccccg ccggccggcc tcgtccgcga
     8641 ggtacgccgc cactggaccg gcttcgtccg ccaaggcgac cccggctggg ccgcgggcac
     8701 cactcaccac ttcacggacg agcccgccgg ccgcacgtaa gagcagaccg tcgtccccgt
     8761 tctcttcgac ggtcatcgcc gactgccccg accgcgtccg ccagatcatg gccgatcgcg
     8821 gcatgcggct gcccagggcg tatcagccgc gctgacggtc gcccccatcg ctccggaggc
     8881 ggcggacttt cctccattcc gccgatcggg tgtgcgcgcc gccggtggac ctccccgatg
     8941 gacgaggcac cgggatgcgg aagggtgccc ggggggaact gaaagctggc cgtggcggtc
     9001 aggtggggta ctcgcatagc gggcgagaag gtttcaatcg gtcgtcgaat tgcttcgttc
     9061 tcccgatatc gacgggtcgg tgcgccggct ttcttccatt gaccggcccg gcaccccttg
     9121 ttatggtcac tctgcgtgaa agattgcgta cacagagttt cctgacgtcc gtcccgcggg
     9181 ccgccgaatc gcgacgaaga atggcgcgcc ggcggccggg agcgcaagga ggtgagccgt
     9241 gaggtctggc ccgaagccac ccagcgacct gacgaagcac aagggcatcg agaccgtccg
     9301 ccagatccag ttcctgatgg tcctgtgctc ggtgctgccg ccggacggaa aggcgcgcga
     9361 gatgctcagg ctcgcgctcg acgtcagcaa cgaggagttc ccggacggtg tcgagccgat
     9421 tcacgatctc cacccgcagg ccaccaagac ctggctcgag ttcttctgga ctcgggtcgg
     9481 catttccccc gaggaaaggg agttgatcga ctggcagaac gacaagccga gcatggacat
     9541 cgccgtcgaa gagctccagg aggccgagcg cagactcggc atcaggctgg cgcctcgaac
     9601 ggtcgagtga acagcaacga accaggagga agaaatgtca cccagcacga ttctgcggca
     9661 cgccgccgcc gacgccgacg tccgcacgga actgctcgcc ggagcgggac ggttcggtgt
     9721 gcccgccgcc gccgtccccg ccgccgtcgc gcagcccgac accgcctcgc tgggctactg
     9781 gaccgagggc gtcgccgccg tcgacgccta cgcctgcgcg tccacgtgca gctcggggcc
     9841 gttcaccttc gcgtgcgacg gcagcaccaa gtagcgcctc cgcgttagcg cccggcctcg
     9901 cgccgggcgc gcggaacacc gatgggccga agccatcggc ccatcacctc cgaccttccc
     9961 ccacaggcga gactgtccca caggcgagga gcccgcccgc gtgaagccga cctttcccgt
    10021 ggacctcgcg gcccgggccg cgaacctgtc cgagcggatc cagatcgtgt ccgccctcgg
    10081 cccgccgtcc ggcgcggagc cgctggaggc cttcgacgcc tggaggatcg accggctggc
    10141 cgccaagctg gccgccaagt tcggcgcgga gaccagcccc cggtcggagc ggcacacgga
    10201 agagtcgctg cgcgagaccc tgcgggccta tcgcgcgcac gagctcggcc tcaccgaccc
    10261 cgaaggccgt ctgggccgga tgctggcgga cctccaccga ggctggctgc cggtctaccg
    10321 ggagacgctg gacgggttcg accccggcga cgaggcgttc gcggcggcgg actggcgctc
    10381 ggacgaggtc taccacggcc ggctcgccac cgcctgcgag cccttcctgg tggagctcgg
    10441 ccgccggctg accagcgcga tcgacggcgg cgggcccgcg gtccgcgtcg actcccggct
    10501 ggtggccgac ttccaggcct acctgctcga ccggttcgag ctggcgctgg cctgggcggt
    10561 ggagaccgac gcgaaggtgc actgccggct gcacgggatc gacccggcga gcgcgaccca
    10621 cgacgactac ctcgcctacc tcgacaagac gttcgccgac accgacgcct atcaccgctt
    10681 ctacctggag ttccccctgc tcggccgctg gctcgcccag acgaccgggc agctcgccga
    10741 gcacggcgcc cagatggtcg gcaggctccg cgacgacgcc gccgagctgt ccgagtcgtt
    10801 cttcgggcgg cccgtcgcgg cggtgcggac cgcgcggctc ggccgttccg accaccacgc
    10861 cgggggccgc agcgtcgcga tcgtcgaggt cgagctcgcg gacggcgcgc aggagtccgt
    10921 ggtctacaag ccccgcggcc tggagggcga ggccgggttc caggggctgc tggcgcggct
    10981 gcgcgccgac ggcgtcctcg actatgccga gcgggccgtg ctccggaggg acggctacgg
    11041 cttcgaggcg ctgatcccgc cgggacgcaa ccgggtcgcc acccgggagg aggccgagcg
    11101 cgtctacgcc gaactcggcg gctacctggc gatcttctat gtgctgggcg gcggcgacct
    11161 gcacttcgag aacgtcctca tcgcggacgg ccacgccttc atctgcgact gcgagacggt
    11221 gctcggagcc ctgcccaagg ggtggccgcg cccgtcgggg acgctgatgg actcggtctt
    11281 caggaccgga ctgatcgagt ggccgaggag cggcgcggca cccgagggcg agatgcggat
    11341 cagcgggtac accggcggcg gcggttacga gatgccgatg ccggtgccgc aggtcgaccg
    11401 cctgcagtcc ttcgcgtcgt ccgtcagcta ccgcgaagga gtgcgggtcg acccgggggc
    11461 cgccaaccgg atcttcgtcg gcgaggagct gacgcacgcc gaggagttcg tcgacgccat
    11521 cgggaccggt ttcgaccggg tctacgagtg gttccggcgg cggcccgacg aggcgatcgc
    11581 ctgcgtccgc gagctgttct ccggttcggg cgtccgcttc gtcaactgga gcacccaggt
    11641 ctactcgcag ctgctcgcgg cggccctgca cccgcggtgc ctgctggagc cgctggaggc
    11701 cgacctgctg atcgagaccg tccgcacctt cccgcgcaag tgggaccagg acgcggccct
    11761 ccccggctgg gaggtcgcgt cgatgtggcg ccgggacgtt ccgctgttca gcgtcgaggc
    11821 gggcggcacc gcgctcgtcc acgaccacgt gtcccgggtc ggggcggatc tggagacgag
    11881 cccgctcgac cacgccgcgt cccggatcag gggcctgtcc gcgcggaacc gcgcgcagca
    11941 gcgccagtac atcgccgccg ggctgtccgg cggcgacgtc acgagcgccg acttcgccga
    12001 gacgtgcgtc gagcgcgcgg ccgcgctcgg ggagcagctc tgcgcgatgc tccgcgcacc
    12061 ggacgcgccc gccccctgga cgtccttcgt gatcgccccc gacgggcgga acgaggtcga
    12121 catcgagggc gacctctaca acggctcggg cggcatcgcc ctgttcctgg cctacctcga
    12181 cgccctcgac ccgcgtcccg agttccgcgc ggcggctcgg cgggcgctgg accacgccgt
    12241 cgccacctgg gaacggcagc gcatcggggc cttcacgggg ctcggcggca tggtctacgt
    12301 cctcacgcac ctgtaccgcc tctggggtga gcgcgccctg ctcgaccgcg ccctcgaact
    12361 gggcgacgag ctggccggac gcatcgacgg cgaccgccac ctggacgtct tccacggcgc
    12421 cgccgggctc atcccggtga tgatcggcct ggccggcgtc gcggacggac gaggcctgga
    12481 gcaggcgcac cactgcgccg cgcatctgct gtgccgcgcg gaggccgagg gcgacgccct
    12541 gtcctggccc ggctccgacc tcggtgcttc cggagccaac ctgaccggcc tgtcccacgg
    12601 cgccggcggc gtcggctggg cactgatcac gctgggccgg ctcaccgacc gcgccgagta
    12661 cgtctcggcc ggacggcggg ccttcgccta cgaggccctc cacttcgacc agagcgcgca
    12721 ggactggtac gacctgcgcg agttccccgg cgggatgctc tgggagggac gccactacgc
    12781 caacgcctgg tgcaacggcg cggcgggcat cgggctgagc cgcatccaga gctgggcggc
    12841 gctcggcaag gacgacgact cggtgctgac cgaggccagg agcgcgctga cggcgacgat
    12901 gcgcaacttc ccgcgcctga tgaacgactc gctgtgccat ggccggtccg gcaacgccga
    12961 actgttcctg cggttcgcgc tgctggcgga cgagcccgcg ttccgcctgg aggccaacgt
    13021 ccaggtgcag gcgcagtggc gcaacctgga ggacgctccg cccgcgtccg ccaccgggtt
    13081 cttccccggg ctgatgctcg gcatgtccgg cttcggaatg cacttcctgc ggctggccca
    13141 tccggagcgg gtcccctcgg cgctcctcct ggaccctccg cccgcgtcga tctgaggagt
    13201 gatctccccc atgtccgtcg aatcctgcgc ggcgttcctg cggtacgccc tccgcgacac
    13261 cgggatcagg cagcagatga aggccatgac cgcggtcgcg gagatgatcc gcctcggccg
    13321 ggcgcacggc tacctgttcg acgcccggga cctcgcggct gcgtcgtcct cgccggactt
    13381 ctccgaggcc gcgcccagag cggcgtccga gaaggcggcg tccggcccgc aggcacccgc
    13441 gcccgccacg gccgaaccga ccgcgttcta ccactacgag tacgacatgg cggaccttcc
    13501 cgggttcgac gccgtcctcg aacaactgcc ggcgctgaag atcaagccgt ccacggtcga
    13561 cctcgcggag ttcgacgccg agttccgcgc ggacgacctg cgctccacgt cgctggcccc
    13621 gaacggcgcg gagtaccacc ggtggcgcgc ggcgccggcc acccggcgca ggcgcgactt
    13681 ccacctcgtc aacctggact cccacaccga ccacgcggac tacgaggcct actacgcggc
    13741 caagatccgg ctggtcgacg cgctggagaa ggtcttcggc ggcgaggtcc ggctgtccgg
    13801 caacctgtgg tacccgccgt ccagctaccg gctgtggcac accaacgagg accagccggg
    13861 ctggcgcatg tacctgatcg acttcgacga ggggttcccc gacgccgagc acacctcgtt
    13921 cttccggtac cagcacccgg agaccgacga gctggtcacc ctgcgggaac gcccgaaact
    13981 ggcgcgcttc ttcaaggtgg agcaggaccc ggaccggctg ttctggcact gcatcgtcaa
    14041 ccccaccccc cggcaccggt ggagcttcgg ctgccacgtc cccgacacct ggctcggcgc
    14101 catcgcgggc cggtcgtgac ggcgcgtccc gccaccgccg cgcccgccgg gcccggcgcg
    14161 gtcgcacccg ccggggcgac gcccgcgatc agggcggtcg ggctgcgcaa gcggtacccc
    14221 ggcgtcgagg cggtggccgg gctcgacctg acgatcccgc ccggcgagag cttcggattc
    14281 ctcgggccca acggggcggg caagaccacc acgatcgcga tgctgtgcac gctggcggtc
    14341 ccgacgtccg gccggatcga gatcgccggc cacgacacgc ggaccgattc cgccgcggca
    14401 cgccgccgca tcgggctgat cttccaggag tccaccctgg acgtccagct gaccgcggcc
    14461 gagaacctga ggttccacgc cgatttgtac aacgtcccgt ccggccaggt ggaggcgcgc
    14521 gtcgaggaga cgctcgccct ggtagggctg accggctgcc gcgaccgcgt cgtgcacacc
    14581 ttctccggcg gaatgcgccg ccgcctggag atcgcccgcg cgctgctgca ccgcccgcag
    14641 atcctcttcc tggacgagcc gacgatcggg ctcgacccga acgcccgcgc ccaggtctgg
    14701 cgccacctgc ggcacgtgtg cgagaccgag tccgtcaccc tcttcctgac cacccaccac
    14761 ctcgaagagg ccgagcagtg cgaccgcatc gcgatcatcg acgcgggccg gatcgtcgcg
    14821 cagggcagcc ccgccgagct gaagtcggtc ctcggcgccg accgggtgga gctgcgcacc
    14881 ggcgacgacg cgaccgcggc gcagctgatc gccgagcgcc tcggcctgga ggtgacccgc
    14941 gaccgccacg ggcttcgttt ccaggtcccc gagggggcac gggtgctgcc ccggctgctc
    15001 accgagctcg acgtccccgt gtacgaggcg cgggtcaccc cgcccagcct ggacgacgtc
    15061 ttcctgcacc acaccgggca ccggatccgc gacgaggccc cacccgagcc gtccgcctgc
    15121 ccgatgcggg tcccgtcggc gtccgagccg ggcaagggcg ggctccgggc cgaactgcgc
    15181 gccatgggga tggtgtggcg gcgcgagatg ctgcacttcc ggcgggaccg cgtcggagcc
    15241 gccatctccc tcgtgcagcc gctgatcttc ctgttcatcc tcggcatcgg cctgtcgaac
    15301 ctgatgcccg ggcccaacgg tgacgcctac cagctcttcc tcttctcggg cgcgctggtg
    15361 acggccgcgc agggacccgc gctcgccacc ggcacctcga tcatgtggga ccggcagggc
    15421 ggcttcctgc gcgagatgct cgcgggcccc gtcagccgcg cgtccctgct gatcggcaaa
    15481 tgcctcggcg gcaccacggt ggccacctgc caggccgcca tcctcctcgc caccgccgcc
    15541 ccggtcggcg tccccctcga cggcgtcctg atcgccctcc tgctgggcga actggtcctg
    15601 gtctcactgg ccatgaccgt cctgagcgtc ctgctgtcga ccatcctgcg ccgcccgcag
    15661 accttcggca ccgtcctgac cgtgatcatg gccccgatgg tgttcctgtc cggcgcgttc
    15721 ttcccgctga gcgcgatgcc cgtctggatg aaggccctgg cactggcgaa cccgctgacc
    15781 tacgccgtcg acgtgatgcg ccgcaccatc acggcctacc taccggacgc cccgcaccac
    15841 ctgttccaac cgctggccct gggctcctgg cacccgccgc tcctcctcga atgcgccctg
    15901 atggccgccc tgacgacagc cgccctgtcc tatgccgccc accgcttcac ccgcctcccc
    15961 tgacgccccg cacaagaacg gcgggatctc ggcgggcgcc ttcactgacc aggcggacgg
    16021 gacgtcccgc cttccgaacg gtcctgccgc agtcgggcgt tgatgcgctg ggcctcggcg
    16081 agttggtctt cgaggatgat gatgcggcag gccgcctcca gggcggtgcc ctggtcgacc
    16141 agatcgcggg cgcgctgcgc caggcgcagc tggtagcggg agtagcgccg atgcccgccg
    16201 gacgagcgct gcggaacgat cagccgggag gtgtccaggc tgcgcaggaa cgccggggtc
    16261 acgcccagca tctcggcggc gcggcccatg ctgtaggccg gatagtcctc gtcgtcgaac
    16321 ttgccttcga gcgcggcgga gtcgtcttgc gcggccgcct gcggtcgctg ctggtcgggc
    16381 tggtcgggct ggtcgccggt ctgggccatg tggggtgctt tcacaaaacc ttccgtactg
    16441 ccgtggcatc ggcaggcggc gacggcaggg ggccccggcg ccatactgcg gcgccggggc
    16501 ccagaggtac aacaccacct accggctctg atgagccggt cttccgcgta ggccgcccga
    16561 ctgcgggcgg ggacgcgggg atcgcgtatg cgtgaccgta gaccaccgtc caatccgggg
    16621 aactgcggta cccgcgcggc gtgactggag cctgctgcgg gcgatcccga tggcgccgat
    16681 ctctcctttc ctcgacatca ctacctgtac tacgtgttcc agtactgcgt acttcttgtt
    16741 ctccactact gacggtgact ttcccgccac cggtccgacc ggctgccgag gccccttgca
    16801 ctgcgctggc cccggcacgc ccggccggcg tcatccatac cctccggcag ttcgtcctct
    16861 gccgcttctc atggattcgt ctctcttcga tggaaggaac actacccggt gccgatccga
    16921 aaatctactc cgatcactac agagtttcgt agatcacagg tcttggttct cctccgtcgg
    16981 ccgagagtgc cccggccacc gcggacaggc agagggcagg ccggggccgc cggccctgag
    17041 agtccgccgc tgtggccccg caccctgcgg aaaggctccg cccctactac ccgcgcgcag
    17101 gggtgggaga cctagaggct ctcgctcgtc cagcgccacg cgccgttctc atgccgagcg
    17161 cggaccagtt gcgtaccgct ggagtccgcc agctcggcga ccagccggat caactggcgg
    17221 tggaagtcgg cgggcgggcg ggttccgccc ggcgtgccct ccaggagcgt cacgctgacc
    17281 ttcgcctcgt cccggagctg cacggtcaac cggcccgtcc tgtccatgcg gaggatcact
    17341 atcgcgtcgg cacggatcag gtcgtcaccc tcggcggcgg agatccacac ttcgctcatg
    17401 agcgtcccct gcccggatcg agggccccgt acgcccggcg tcccccttcc gtgcgctcca
    17461 cgccctcatc gaggctcgcg gacgcggccc caccggcgtc gcagctgatc agcgaggtgc
    17521 cgctcggccc cgccgccccg gtcgccgtcc ggcgagagga gcggtcgccg gactccggcg
    17581 gggtcgggcc ggagggcgta gactctgggt gagctagggg ttctcgatgc gggcggccaa
    17641 gccggcgtcc ccctggtttc cgatgatcgg tctccctgag gccagacagg ccggcgcgca
    17701 tgacgccgct ccaccgtccc tctcgaacgc ggacgcccgt tctcggcgcc ggccctgccg
    17761 cccaccaggg ccgcggtgcg gcgtccacgg gtctttgagc ggtcccggcc acacgcacac
    17821 tcctgatcgg agccccagat gcataccgca ggcaccgcct cccccgaggc cgggctgcgc
    17881 cgcgaagcgc tcacggaaca caccgtcatc accatcaccg gcgatctcga catcgcctcc
    17941 gcgccgtccc tgcgcgggcc cctggagacc gcgctgcggg acgcgggccc cctcgtggtc
    18001 atcgacctgt ccgaggtgac gttctgtgac gcggccgggc ttgctctgct caccggcgcc
    18061 cgccgcgtcg cggaaccgga gggcgtcacg ctcgtcctcg ccgctccccg cccgcacatg
    18121 gtcaggctcc tgcgggtcag cggcctggcc cgggtcttcg ccgtccgccc caccgtcgat
    18181 gccgcgcaca tccgatcggc cgcggcctga gcacgcggcc cggcccggac ggagcgggag
    18241 gacgggatga cgacatgacg ggcgacccgg gatcgatcgg gtggggcgcc gccggagccg
    18301 caccgagcga tgcggaccgt cggcgcctcg cggccacgtt cgagctgatg agcgcggtgg
    18361 tcctggaggg gaccgacgtg ccgggcatgc tggccctcgt ggcggcgcac gcccgggaac
    18421 tggcgcacgt cccgctggcg ttcgtcgccc tgcccggcga ggacggcaac acgctgcggg
    18481 tcgaggtcgc ggacggcccc ggcggcgacc ggatacgcgg gctgacggtg cggcggggcc
    18541 ggtccatgct cggccgggcg ttcacatcgc gccgggccgt gtccgcgcgg atcgccgccg
    18601 accagacgct caccggcctt ccggccggtc ccatcctgat cctgcccctg gagacggggg
    18661 aggccacccg gggagtgctc gccgtcctcg gacgggtcgg agcggagccc ttcggcccgg
    18721 cgaccgcgcg ccagatgctc ctgttctccg acatggccgc ccggctgatc gaggtggccg
    18781 gggcccgcca tccgggcgcc tcgccgggag tcgccgagtc gaccctgcga ccgcagtcgt
    18841 cgggctgacg ccgacgcggc cgcggcgcct tcgccgctag gggatcggcc tccgggggcc
    18901 tgtccgggcc cggccggcgg cgctcgcccg ccccgtggat tcgggctgtg ccgcgccggg
    18961 tccccggcgg tctttcagag cctgaaaagc ttcgtgaacg gtgagaggat ctttactttc
    19021 cgtgtcccga agtcgaccag gacggcgttg cccggctcga cctccaggac gcgcccgagc
    19081 ccgtacttgt cgtgcgtgac ctggtcgtcg agggtgaact ccttggccgg cggagcggcg
    19141 ggcgggggtt tgaaggggct ggtgggcagg tgtcgccgtc gggcggggcc ggtgggtttc
    19201 attacctcat tatgcgcgta ccgggcggtt ccctgaagcc ttctcgcgga ccggctggta
    19261 aattctcgcg acaggcgccc cccctgatcc gcccggcgaa tcctgtggta ccgtagttcc
    19321 cagttgcggt tcccatagac atgtgcgtgc gcctgttgga tctgacctca ggcgcacttt
    19381 tgttttttct ggatcttccg gatgggccat cgcggcgtct tcgtccgcac acggtgtgcg
    19441 gacggggcac accctgaagg agacgatcat ggccaccggt accgtcaagt ggttcaacgc
    19501 ggaaaagggc ttcggcttca tcgagcagga cggcggcggc gccgacgtct tcgcccacta
    19561 ctccaacatc gcggcccagg gcttccgtga gctccaggaa ggccagaagg tgacgttcga
    19621 catcacccag ggccagaagg gcctgcaggc ggagaacatc gttcccgcct gatctcggcg
    19681 taggcggtgc gcggtcccga gggccgcgca ccgcaatgct gtccgggcac ctgatccgcg
    19741 cccctcgtct ctcccggtcc acggcggaaa cccccgctgg accgctcccg gttcgttctt
    19801 gagaatcctc cacccggact cctgccgagt ccgcgttgcc gcatgacgga gcacttccct
    19861 gacacgcacc gctctcaagg aaggcttcac catgccccgc gccccccgat cgagcggccg
    19921 aggttcccgg cctcgtcccg cccgccgtcc ggcggacggg cgaaggcccg acgccaaggc
    19981 cacgcctccg gccgcggtcc aggccacgcc ggcggcgccc gccgtcgcgt cgttcgccga
    20041 actgccgttg ccggccccgc tcctggacac gctgggccgc cagggcgtga ccgcgccgtt
    20101 ccccatccag gccgccgccc tcccgaacgc cctcgcagga cgggacgtcc tcggccgggg
    20161 acgcaccggg tcgggcaaga cgctcacgtt cggcctcgcg ctcctcgccc gcaccgccgg
    20221 gcaccgcgcc cagccccgcc gtcccctcgc cctggtcctg gtccccaccc gggagctcgc
    20281 ccagcaggtc accggcgcgc tcgaaccgta cgcggacgcc gtggacctgc ggatgaccac
    20341 cgtggtcggc ggcctgccga tcgcgcgcca ggcgaacgcg ctcgcacggg gcgtcgacgt
    20401 cctcatcgcc acgcccgggc ggctcgccga cctgatcgag cgcggcgact gccggctcgg
    20461 cgacgtgcgg atcacggtgc tggacgaggc cgaccagatg accgacctcg gcttcctgcc
    20521 gcaggtcacc cggctcctgg agcagacgcc gcccgacggg cagcggatgc tgttctcggc
    20581 cacgctcgac ggcggcgtcg accggctcgt ccgccggttc ctcagcgacc cggtcaccca
    20641 ctcggtcgac ccgccggccg gcgcggtcac cgccatggag caccacctgc tgcacgtcac
    20701 cgacaccgac aagcacgaga cgaccgtgca catcgcggcc cgcgagagcc gcgtcatcat
    20761 gttcgtcggc aagaagcacg ccgcggaccg cctcgtccgc aagctgaccg cccgcgggat
    20821 cagcgccgcc gcgatgcacg gcggcaagac gcagtcgcag cgcaaccgcg cgctggacgg
    20881 cttccaccgc aaggacgtca ccgtgctggt cgccaccaac gtcgccgccc gcggcatcca
    20941 catcgacgag ctcgacctgg tcgtcaacgt cgatccgccc gccgaccaca aggactacct
    21001 ccaccgcggc ggccgcaccg cccgcgccgg gaacgccgga accgtggtca ccctcgtcct
    21061 gcccgagcag cgccgcgaga tggacgacat gatggccaag gcgggcatca ccccccgttc
    21121 cgcccgcgtg cgccccggcg atgccgacct cgcccgcatc accggcgccc gcccgccggc
    21181 ccgcgccgcc gccgccccga acaccgcccc ggcccgcaag ccgcgtcccg ccgcctccgg
    21241 ctcccagcgc gggaactccc acgccgccgc cccctcgcgc aggccgcggc ggcgagcgtc
    21301 ctccctcaac agctgacccg agccgcccga gcttcgtcgg ccgtcgccgc ctaagccgag
    21361 acctccgccg gagcgtcttc gacacccagg tacccgcccg tgtagtcgat gatctccctg
    21421 acatgcgcgg cgatgcgccg gggacatcct tcgcggtcgt ccaccggcgc ggagtccggc
    21481 gccatcgccc gagcgaggcg gggcaggtcg cggagcttga tcctgggatg cgcctccggg
    21541 tgggggcacg gccggtcgag cgccgagaga tcgaacgtct gcaggccctc gcggtagagg
    21601 gcgaccacgc cgggggcggc ggctcccccg gcgcagcgct gcgccaggta actcacggcc
    21661 agtgccagcg acacccgttc cccgggacgc gcgtcgccga gcagccgccg cgccgcccac
    21721 agcgccgccg actcggccgt gggatcgatg ctgctgtact tctgcagctc gatgtcggtc
    21781 atcaccgcgt cgaggtcggt gcggccctcc ccggtcagga agtgctcgtc caggtgcgcg
    21841 gtgtcccggg cctcgaagcg ctccgcccgc gcgtccctga gcgcctcttc ggcctcggcg
    21901 gccagctccg cgaggaagcc ggggcaggcg taggcctcga cgtcctcgtc gtccgggtcg
    21961 cggtccgggt cagtggcgaa ccacttctcc ggatccccga tgcgcgccac gacgtcgccc
    22021 atcgcctcgg ggtcgtcgtc gacctgcggg tgctcgtgct ccccgggcgc cgtgcaacct
    22081 gcggcctcca gcaccgtccc ggcacgtccg gcggcctcga tcaggtcgtc gaccagggcg
    22141 ggatcggtga cctgccactt gacgtaccag cggctcgccc agagcgcggc ggtcatcgca
    22201 cgtccggccc gggtgcccgg gccggacctc acctcggcgg cgatccagcc gagcagctcg
    22261 taggggtcgc cgttgggata gccatggagc atgctcgcga gctcgcgggc cacgtccgcg
    22321 tagtcgatcg catcgtcgtc agagaccatt gatcaagcaa accagtcccg gtcggcgcgc
    22381 gggcatcggg gcgtcaggaa tgccgccaga ccgtgccgac ctgggtaccg gcccagacgg
    22441 tggtggtgtg cgggacgcgg gtcatcgagt acgcggtcac cccgacgggc ggcgtgacac
    22501 cggtccagga cgcgccgtcg aagtgcagca ggtgcgcggg gtcgaacggg ctggacaccc
    22561 agacgccgcc ccgcccgtcg gcggcgatcg agccgaggaa gccgaccgtg gacatcgggt
    22621 gcacctcgcc ggccgaggcg gacgggctcg ggagcttgtg cacggtgaac ccggagccgt
    22681 tccagtggtg cagcgtcggc ggcgggaaca acggatgctg ttcgagggcg tagaaccaga
    22741 cgtcgtttgg ggcgacgtac tcgatctgca ggatccagtg ggcccattcc gagccccatg
    22801 gggtacgcgt ccagtccgtg ccgtcgaagt gccacaacgg cgtgggaccg gtctgcgact
    22861 cgccatatcc cccgacccag acgtccgagg cgctcccggc tgcgatggcg ttgagcccgg
    22921 agggctgcgg aagggtgagg gcgttcgtcc actgaccatg ccgccgcacc gacaccgtcg
    22981 tggcgtcccc accgatcccg gtcgcccaca gcccgccggt ccggtcgacg tcgatggcct
    23041 ggagcagttc gccggcgggg cctgccaccg tcgtccagcg gcgtccgttc cagcgcagca
    23101 ggtccgtgcg ctcctgggcg ttctggcccg cggcgagggc ccacacgtct gcggcgtgcc
    23161 aggcgcggac gtcgttgacg gcgaccagcc cctca
//
