LOCUS       NZ_BMRD01000001        21020 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Actinomadura citrea strain JCM 3295 sequence01, whole genome shotgun
            sequence.
ACCESSION   NZ_BMRD01000001
VERSION     NZ_BMRD01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Actinomadura citrea
  ORGANISM  Actinomadura citrea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 994668)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: BGI assembly pipeline
            Genome Coverage                   :: 127X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648455.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,339
            CDSs (total)                      :: 8,265
            Genes (coding)                    :: 8,175
            CDSs (with protein)               :: 8,175
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 12 of 90
            Pseudo Genes (incomplete)         :: 83 of 90
            Pseudo Genes (internal stop)      :: 3 of 90
            Pseudo Genes (multiple problems)  :: 8 of 90
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:33:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 547091
            Orig. end                         :: 568111
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMRD01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21020
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21020
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21020
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11020](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11020)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(425..1276)
                     /gene="panB"
                     /locus_tag="IEZ14_RS02615"
                     /old_locus_tag="GCM10010177_05290"
     CDS             complement(425..1276)
                     /EC_number="2.1.2.11"
                     /GO_function="GO:0003864 - 3-methyl-2-oxobutanoate
                     hydroxymethyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0015940 - pantothenate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="panB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654918.1"
                     /locus_tag="IEZ14_RS02615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05290"
                     /product="3-methyl-2-oxobutanoate hydroxymethyltransferase"
                     /protein_id="WP_179833686.1"
                     /transl_table=11
                     /translation="MSSSVAPPAQPTALYGGTSGRRVTVRDIAAAKQRHEKWPMLTAYD
                     ALTARIFDEAGIPVLLVGDSAAMVVYGYDSTIPVTVDDLIPLTAAVVRGSKRAMVVADL
                     PFGSYQTGVTEALTAATRFLKETGAHAIKLEGGRRIIPQAEAMVAAGIPVMGHLGLTPQ
                     SVNVFGGYRVQGRGQDGDELMADAKALEAAGAFSVVLECVPEDLAARVTASLSIPTIGI
                     GGGNQTDAQVLVWQDMAGLTPHTAKFVKKFADMNTLLGEAARAYADEVVGGVYPAPEHT
                     YH"
     gene            1429..2991
                     /locus_tag="IEZ14_RS02620"
                     /old_locus_tag="GCM10010177_05300"
     CDS             1429..2991
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889307.1"
                     /locus_tag="IEZ14_RS02620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05300"
                     /product="MFS transporter"
                     /protein_id="WP_179833687.1"
                     /transl_table=11
                     /translation="MDPQTIQRRRWYILGVLTMSLLVVVLDNTILNVALKTIADPDKGL
                     GATQSQLEWAINSYTLVFAGLLFTFGVIGDRIGRKRVLVGGMAVFAVASLVSAYAQSPE
                     QLIYARALMGLGGAAVMPQTLSIITNVFEPHERARAIGIWAGAVGLGVAIGPLTGGLLL
                     AHFWWGSVFLINVPVIAVGVTLMAFLVPESRNPAPGRLDPVGVVLSVIGLVVLSYGIIQ
                     GGERGDWLELSVLGPILAGAAVLALFVWHEARTVSPAFDVRLFKDARMSAAVASIALCF
                     FAATGVFFFANFYMQSVRGLTPLQSGAMVLPFAVAQLAFAPRSAAMVRRFGAKAVCTIG
                     LLLVSVALASYQFVGVHTSLWILGAIFFVQGAGMANVMPPATESVMSALPREKAGAGSA
                     INNTARQVSVAMGVAVLGSVVASVYRGDLRDELAALPAGARQAAAESIEGAHAVAAQMG
                     PAGQGLVGPADAAFVHAMHAASVAAAVISFLGALVVLKWMPGRVAAPPAQAPAERRPEK
                     APV"
     misc_feature    1466..1486
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.33"
                     /tool="antismash"
     gene            3021..3650
                     /locus_tag="IEZ14_RS02625"
                     /old_locus_tag="GCM10010177_05310"
     CDS             3021..3650
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889308.1"
                     /locus_tag="IEZ14_RS02625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05310"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_179833688.1"
                     /transl_table=11
                     /translation="MTETERRQAGRPRSERAGKAIVEATLDLLAEESGVAGVSIEAVAA
                     RAGVGKTTIYRRWPSKEALIVHALGAVKEPLPEPSGASAREDLTVIARRLAGDRHRRYS
                     RCFWNVVGGAEKHPELYARYRQEVIEPRRDVIRRVIRRGVDSGELRPDLDVEVAMSLLL
                     GSLTAKRPQETFPEGYAEAVVDTLLRGIESDRETRPEADIGRFSAR"
     gene            3749..5869
                     /locus_tag="IEZ14_RS02630"
                     /old_locus_tag="GCM10010177_05320"
     CDS             3749..5869
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630926.1"
                     /locus_tag="IEZ14_RS02630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05320"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_179833689.1"
                     /transl_table=11
                     /translation="MAPRGDAPATDSASRTLVLGIDGARHIVQCGPNAKAVLGRAPEEL
                     IGRPATDLVGDEAKAELETLLEANGGGQERNGVMGVLRGDGGAPADALLTVQPMLGGST
                     GAAPAALLFIRVELPPSERYQDPALMRRALMDDPLTRFGATLDLDQSARGLVDVVVPHF
                     CNVASVLVLESLVAADEVHAESGSAVLRRIAVTSDDGNPAWTSTFPVGEVLVFPEGTPY
                     RQVMETARPVHLPHIAVDAASEIGRLWRRGPAGELLSNVSMVLLPMIARDTLLGFIACT
                     RIPGFRKFDAYDVEIGMEFAARAAIVIDNARRYSRERATALALQRSLLPMRLSAPSSVE
                     VRHRYLPGSKLVEVGGDWYESIALPGARVALIVGDVAGHGVRAAVTMGRLRTALHTLAN
                     LELPPADALHVMHELMIELGEQEPHFATCVYAVYDATTGTIEIASAGHLPPLLASPTGD
                     NEYLEVPPAPPLGVSGGSAIESREFPVEDGSLFVIYTDGLVENRGRDIDDGLARLQKIF
                     GRDSVDRSMEDLAKTTLAGVYADQHRDDIAVLIARLRRLPPDRYSSWTLPADPAAVRRA
                     RGLVSTRLAEWDLEDLDYTTELLASELITNALRYAHGPIELRLLLERTLVLEVLDRSAA
                     LPRLRRAEDDDENGRGLLVVSQLAHRWGSRRTAAGKVVWCEQIVPGVDPDASEQVPAWP
                     EEAWPGELHHRE"
     gene            complement(5898..7688)
                     /locus_tag="IEZ14_RS02635"
                     /old_locus_tag="GCM10010177_05330"
     CDS             complement(5898..7688)
                     /EC_number="6.3.5.1"
                     /GO_function="GO:0003952 - NAD+ synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131505.1"
                     /locus_tag="IEZ14_RS02635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05330"
                     /product="NAD+ synthase"
                     /protein_id="WP_179833690.1"
                     /transl_table=11
                     /translation="MAQLRLALAQVNSTVGDLDGNADQILTWTRRAAEAGAHLVAFPEM
                     MLTGYPVEDLALRASFVEASRDALQHLARRLADEGLGDLPVVTGYLDRPPAGGARPGRP
                     GGLPLNAAAWLHRGEVLVRSAKHHLPNYGVFDEYRIFARGDRLPVVRLHGVDVATAICE
                     DLWQDGGPVSVTSASGAGLLLVINASPYERDKDDARLDLCAGRAREAGCALAYVNMVGG
                     QDELVFDGDSVIVGPDGSPLSRAPQFVEHLLVTDLDLPAAGPAAEAGPVRVDAQDGTTI
                     TIDRHVLSADPLPAYPAEPRTVARPLEDLAEVYAALVLGTRDYVRKNGFRSVVLGLSGG
                     IDSALVATIASDAIGPEHVHAVLLPSRYSSEGSVVDAEELVKRQGVHSRIVPIAGMVEA
                     FEEQLDLHGLAAENLQARIRANVWMALSNEDGHLVLTGGNKSELATGYSTLYGDSAGGF
                     GPIKDVFKLTVWDLARWRNAQAGKDSPLLHPFAHEPIPEAIIVKEPSAELRPDQRDRDT
                     LPDYAVLDPILTDYVERDMGRDALVKAGHDPALVERAIRLVDIAEYKRRQYPPGPKITP
                     KNFGRDRRLPITNRWREKLS"
     misc_feature    7715..7735
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.8"
                     /tool="antismash"
     gene            complement(7721..8980)
                     /locus_tag="IEZ14_RS02640"
                     /old_locus_tag="GCM10010177_05340"
     CDS             complement(7721..8980)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654915.1"
                     /locus_tag="IEZ14_RS02640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05340"
                     /product="MFS transporter"
                     /protein_id="WP_308427157.1"
                     /transl_table=11
                     /translation="MSTLEKTPVGPAPGRFAAFLGPRVGGFPRPFWVLWAGTLLNRLGT
                     MVEPFLGLYLTTMRGLSLTQAGVTMAVLGAGSLAGQLAGGMLADRIGRRATLTLATVGT
                     GAAMLALGYAQGLAAILAAALVLGLLLDMYRPAAQAMVADIISPADRPRAFGLLFWAIN
                     LGWAVAMVLGGTLAQQGFLWLFWIDALTCAAFGLLVWRAIPETRTRDARAERTGGFGRV
                     LRDRVMVGYVLVTLLYTFVLMQGMTTMPLAMKEDGLGPRSYGLAIAANGVLIIIVQPLV
                     NAWLARRDHSLVLAAGFALVGVGYGLTSLASSVPAYTATILVWTLGEIIAASVLQAVVA
                     DLAPAGLRGRYGGLYGMAWSGGFLLAPLGGTQLLGAGGAPALWLTCAALALAAAAAQLA
                     LAPAIRRRRAAVLGVHFSSK"
     misc_feature    9018..9038
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.62"
                     /tool="antismash"
     misc_feature    complement(9019..9039)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.43"
                     /tool="antismash"
     gene            9036..10061
                     /locus_tag="IEZ14_RS02645"
                     /old_locus_tag="GCM10010177_05350"
     CDS             9036..10061
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630923.1"
                     /locus_tag="IEZ14_RS02645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05350"
                     /product="DUF5937 family protein"
                     /protein_id="WP_179833691.1"
                     /transl_table=11
                     /translation="MIEFVLAPDDVARVRFAFSPLWEMVRSLRVLADPSGHALHLPWVR
                     TVRPRLRGLGFEPLLDVVLPAGYIPDFLTPPPRTPLPDLGAELATVRATPPEVVAAELS
                     WTAPGARPRSARRALAADPEGTLERLADLLERYWEVAVEPFWPRIRDLLEGEVLRRSGA
                     LAAEGAEGVFGDLHEAVSWRAGTLSVDRHWDFRGELAGRGILLVPSAYVWPNVSVMVPP
                     YQPMLSYPPRGVATLWETGPPDEPRAGALAALMGRRRAELLTALSTPASTTDLARRAGV
                     TAGAVSQHLGVLRACGLVTGHRMGRRVLYVRTPAGDALAGAQRSDASASRRDGPGEAPG
                     P"
     gene            complement(10001..11020)
                     /locus_tag="IEZ14_RS02650"
                     /old_locus_tag="GCM10010177_05360"
     CDS             complement(10001..11020)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654913.1"
                     /locus_tag="IEZ14_RS02650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05360"
                     /product="terpene synthase family protein"
                     /protein_id="WP_179833692.1"
                     /sec_met_domain="T1TS (E-value: 2.1e-50, bitscore: 168.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDISLLLSMTDRVTALATPSAMHPESWQLCAQVEAWARGRGLVLG
                     DPDTSPLGRARCERLAARVLPSADLAAVDLFARWLTWTLALDDTLDHPPLADSGSAVHA
                     LYDDLLRAMRRGHARPGARPLEAALVELWQATSKDMSRDWRRRFMLHLEAHRDGCAEEA
                     VNRRISHVPTEQEYPALRRRACGPFLFDLVEAVLGVELPARLLRTPRWKTLADGIADVV
                     AWANDLASHDLEAARGDVHDLPAVLARAHGLDEARAAHRVADRIADRLEEAWAAARRLP
                     EMLDRLDLTVAQRAAAAQVVKVLLDTPRAHMDWLAESGRYGPGASPGPSRLDALASLR"
     misc_feature    11082..11093
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.12"
                     /tool="antismash"
     gene            11193..12017
                     /locus_tag="IEZ14_RS02655"
                     /old_locus_tag="GCM10010177_05370"
     CDS             11193..12017
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889662.1"
                     /locus_tag="IEZ14_RS02655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05370"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_179833693.1"
                     /transl_table=11
                     /translation="MSRRTTLRAFGAGLAALALTASACGGDKGATVQGVKLIEKGALTS
                     CTHLPYPPFQSEDKKSGKVVGFDVELIDLVAKRLGVTQKIVDTPFETMKTGSALNAGKC
                     DIQMGGMTIKPDRVKFMDVSTPYFDATQSLMAKKGSGITTLDDVKAKKLKLGSQASTTG
                     EDFVKGKGFDPRSFDNSNAELDGLRTGQVDVIVQDDPVVKGWLKDPANAGFEIAANLNT
                     GEQYGFWMRKGHNPELVKMTDQVIAQAKSDGSYKRIYEKWIGPMPPSAGGGS"
     gene            11975..12844
                     /locus_tag="IEZ14_RS02660"
                     /old_locus_tag="GCM10010177_05380"
     CDS             11975..12844
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630920.1"
                     /locus_tag="IEZ14_RS02660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05380"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_179833694.1"
                     /transl_table=11
                     /translation="MDRSNAAQRRRRLVTAEPAGVAAPGGLTRRRRRQLSLGGQYGIFA
                     VVVVLVLGLADWGTLRLNFANWDVAKSLFPDIITVGLRNTAVYTAVGFGIGLGGGLVVA
                     LMRLSSVPPYRWFATGYIEIFRGLPLLLIFIFVGVGVPLAFPGTNIPGGAAGQAGLALG
                     LAATAYMAETIRAGIEAVPKGQLEAARSLGMSHTRAMRSIVIPQAFRIIIPPLTNELVL
                     LCKDSSLVLFLGITLEQRELTKFGRDLAGEQGNTTPIIVAGICYLLITIPLSLLARRLE
                     ARQRRGRR"
     gene            12841..13680
                     /locus_tag="IEZ14_RS02665"
                     /old_locus_tag="GCM10010177_05390"
     CDS             12841..13680
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017585597.1"
                     /locus_tag="IEZ14_RS02665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05390"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_179833695.1"
                     /transl_table=11
                     /translation="MTSLVKDTGDPAAGPAAIEISGLYKSFGANEVLRGIDFHVGAGEV
                     VCVIGPSGSGKSTLLRCVNLLEEPSAGTVRVAGADVTGPEVDIDAVRRRIGMVFQAFNL
                     FPHLTALGNVMIAQRKVLKRGRAEAERIARENLERVGLADKVDAYPAQLSGGQQQRVAI
                     ARALAMGPEVMLFDEPTSALDPELVGDVLGVMRGLAEAGMTMLVVTHEMSFAREVADRV
                     VFMDGGVVVEEGPPAQVIGEPAHERTRTFLSRVLDPAAARIEDGPRSDMFRSPAPDA"
     gene            13806..15167
                     /locus_tag="IEZ14_RS02670"
                     /old_locus_tag="GCM10010177_05400"
     CDS             13806..15167
                     /EC_number="6.3.1.-"
                     /GO_function="GO:0004356 - glutamine synthetase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013151975.1"
                     /locus_tag="IEZ14_RS02670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05400"
                     /product="glutamine synthetase family protein"
                     /protein_id="WP_179833696.1"
                     /transl_table=11
                     /translation="MDRQQEFVLRTLEERDIRFIRLWFTDVLGFLKSVAVAPAELEGAF
                     GEGIGFDGSAIEGFARVYEADMIAKPDPSTFQVLPWRSESPGVGRMFCDILMPDGTPSF
                     ADPRYVLKRSLARAADLGFTFYTHPEIEFFLLNDKPEDGREPEPADAGGYFDHTPHSAA
                     HDFRRNAITMLEAMGISVEYSHHEGAPGQQEIDLRYADALTTADNIMTFRLVMKEVALE
                     QGVHASFMPKPYTEHPGSGMHTHMSLFEGDRNAFYEPGAEFKLSKAGRAFIAGLLRHSA
                     EITAVCNQWVNSYKRLWGNVGSAAGLGGEAPSYICWGHNNRSALVRVPMYKPHKGHSTR
                     IEFRSLDTAANPYLAFAAILGAGLKGIEEGYELPPGAEDDVWALTVAERRALGIEPLPQ
                     NLDEAIRAMERSELMADVLGEHVFDFFLRNKRQEWEDYRRQVTEFERKRLLAVL"
     gene            15196..18234
                     /locus_tag="IEZ14_RS02675"
                     /old_locus_tag="GCM10010177_05410"
     CDS             15196..18234
                     /EC_number="2.7.7.42"
                     /EC_number="2.7.7.89"
                     /GO_function="GO:0008882 - [glutamate-ammonia-ligase]
                     adenylyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853431.1"
                     /locus_tag="IEZ14_RS02675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05410"
                     /product="bifunctional [glutamine synthetase]
                     adenylyltransferase/[glutamine
                     synthetase]-adenylyl-L-tyrosine phosphorylase"
                     /protein_id="WP_179833697.1"
                     /transl_table=11
                     /translation="MTESWTSDRRPSLAGRLARLGFTHAARAERLLAEAERDGAGPGDG
                     LLDALGGTADPDLALDGLLRLLPAAGGGLRAALAAEPGTRERLTAVLGVSAALGDHLAR
                     HPDHWRVLRDGVAGPLGSPRADLLSAVGADPAAPEPVARGEDALVALRVAYRRRLLALA
                     GRDLIGAADVAEVAAELADLAAAALEAGLAIARAEVPGHEACRLAVIGMGKCGGRELNY
                     VSDVDVIFVAEAREGRDEDAALRTATRLASAMMRACSATTEEGALWEVDAALRPEGRSG
                     PLVRTLASHRAYYERWAKTWEFQALLKARPVAGDADLGARYLETITPIVWKAAEGESFV
                     EDVQDMRRRVEADLNQRTADSERQLKLGPGGLRDVEFAVQLLQLVHGRADETLRSPTTL
                     DALADLSRGGYVARDDAAALASAYRFLRRVEHLVQLHRLRRTHLVPDDEAGLRRLGRAL
                     GLRTDPVGEFTALWRRHAREVRRIHEKLFYRPLLRAVARLPGEEARLTPEAARVRLEAL
                     GYADPAGALRHIEALTAGVSRRAAIQRTLLPVMLGWFADAPDPDAGLLGFRQVSDALGT
                     TPWYLRLLRDEVTVAERMAWVLGSSRYATDLLLRAPEAVALLGSDTGLAPRPYEALRAE
                     ALAAVRRHKEGTGGKPGEEGRAGARPAEEAAGVVRALRRRELFRVAVADLLGLVDVREV
                     GEALTGISTVTVEAALQLAVNKIEMESRGPLPTRMAVVAMGRFGGHELGYGSDADVMFV
                     HDPLPGADEGAAGRAAYAVAEELRRLLALPAPDPPLVIDPNLRPEGRQGPLVRTIASYA
                     AYYARWSEPWEAQALLRADPMIGDPGLCERFRALIDPVRWPEDGIDEDAVRQIRRLKAR
                     MESERLPRGVERRLHTKLGPGGLADVEWVAQLLQLRYAHEVPALRTTRTLDALDAAVEA
                     RLLDAEDAETLAEAWCMATRVRGSLMLVRGRASDLLPTDHHRERSSVARVLGYPGTGDL
                     LEDYRRHARRARLVVDRVFYGAE"
     gene            complement(18219..19079)
                     /locus_tag="IEZ14_RS02680"
                     /old_locus_tag="GCM10010177_05420"
     CDS             complement(18219..19079)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630915.1"
                     /locus_tag="IEZ14_RS02680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05420"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_229809892.1"
                     /transl_table=11
                     /translation="MAQSAPPAARRSEAGATGMRRRVITAPPVWRELLLVVLFYSGYTL
                     TRIVLVQDGTGPAFAHADEILRAERFLGLDVELHLNQTLLTVPWLARTANVFYATMHFI
                     VTLATVVWLYRYRPQHYRWLRTSIMIATGVALIGFWLYPLAPPRFLHSEGFVDPVTALH
                     SLGLYASDASGSLTNQYAAMPSMHAGWSLWCGLVLVRLASQRWAKLLGVLYPATTVIVI
                     LSTANHYVLDAVAGMAVIGGALWASWILYTRCPAPLLIARARVMHRFHQRTGRRTGGSG
                     AHSAP"
     misc_feature    19236..19253
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            19319..20899
                     /locus_tag="IEZ14_RS02685"
                     /old_locus_tag="GCM10010177_05440"
     CDS             19319..20899
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (137-498). E-value: 9e-19.
                     Score: 60.0. Matches aSDomain:
                     nrpspksdomains_IEZ14_RS02685_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540185.1"
                     /locus_tag="IEZ14_RS02685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010177_05440"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_179833698.1"
                     /sec_met_domain="PF00561 (E-value: 1.7e-29, bitscore: 99.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARYRGISGAVPAGAATLAALTLVSLSGGTGHARTSPRAATGTAP
                     AATDTSPVAAPRLSWGRCTGLPAPPPGSKPPRGLRCAALPVPLDHARPSGEKIELALIK
                     VPATDPRRRIGSLVFNFGGPGGEGVDTLAQAAGQYAGLRARYDLIGLDPRGVGRSSPVA
                     CVDDRRMDAIAAMDDSPDTAAEEQAYTAGRADYVRQCEARSGRLLPHVGTADAARDLDT
                     VRAAVGDERLHYFGISYGTWLGASYAHQFPARVGRAVLDGAVDTRLGRVDLALQQAAAF
                     QRALGGFGAACARLGKKGCPLGTDGPSVVASIGRFLAGLDQSPLRTSSGRRLTQSLGTA
                     GVAAALYSRDAWPYLAQGLVDAVKRRDGSLLLMLADVQNGRRQDGTYSNLSAANTAITC
                     ADGADRPGATDVRRLLPRFREASPIFGTSLAWGLLQCTGWPVRGDAAAREVSAPSAAPI
                     LVVGNTGDPATPYAWASALTDALGGRATLLTLKGEGHGSYDTGDPCVREAVHAYLLRGT
                     VPARGATCG"
     misc_feature    19379..19381
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        19730..20812
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEZ14_RS02685_Abhydrolase_1.1"
                     /evalue="9.00E-19"
                     /label="IEZ14_RS02685_Abhydrolase_1.1"
                     /locus_tag="IEZ14_RS02685"
                     /protein_end="498"
                     /protein_start="137"
                     /score="60.0"
                     /tool="antismash"
                     /translation="QYAGLRARYDLIGLDPRGVGRSSPVACVDDRRMDAIAAMDDSPDT
                     AAEEQAYTAGRADYVRQCEARSGRLLPHVGTADAARDLDTVRAAVGDERLHYFGISYGT
                     WLGASYAHQFPARVGRAVLDGAVDTRLGRVDLALQQAAAFQRALGGFGAACARLGKKGC
                     PLGTDGPSVVASIGRFLAGLDQSPLRTSSGRRLTQSLGTAGVAAALYSRDAWPYLAQGL
                     VDAVKRRDGSLLLMLADVQNGRRQDGTYSNLSAANTAITCADGADRPGATDVRRLLPRF
                     REASPIFGTSLAWGLLQCTGWPVRGDAAAREVSAPSAAPILVVGNTGDPATPYAWASAL
                     TDALGGRATLLTLKGEGHGSY"
ORIGIN
        1 cgtactgcct cggcctgctg cagaacgtgt ccgccgagga ccaggccgac ctgcgcacgg
       61 ccgtggacgc gctcgccggc agcgagatga ccgacggcca gatggccctc aacctggggc
      121 tgctgctgat gaacgtcgcc ggccccgacg tgctgcgctc cgccgtggac acgctccgcg
      181 acgagatcac ggcggacggc gcggccctgc gccgcctccc ggggccgcgt gacggccagg
      241 accacgagaa cggccggccc ggtggcggga cacggcccga acgggtccgc tccgaccccg
      301 accagtagcg agggtcgccc agccttcccg gccgcgtgac acggccggag accacacacg
      361 gccgcgccgg gggcggcgcg gccgtgcggg ggtgggcctg gttcggcgct gaggcccgtg
      421 cccgctagtg gtaggtgtgc tccggggccg ggtagacgcc gccgacgacc tcgtcggcgt
      481 aggcgcgggc cgcctcgccg agcagggtgt tcatgtcggc gaacttcttg acgaacttcg
      541 cggtgtgcgg ggtgagcccg gccatgtcct gccagacgag gacctgcgcg tcggtctggt
      601 tgccgccgcc gatgccgatc gtcgggatgg acagggacgc cgtgacgcgg gcggcgaggt
      661 cctcgggcac gcattcgagg acgacggaga acgcgcccgc cgcctccagg gccttggcgt
      721 cggccatcag ctcgtcgccg tcctggccgc ggccctgcac ccggtagccg ccgaagacgt
      781 tcaccgactg cggggtgagg ccgaggtggc ccatcaccgg gatgccggcc gcgaccatcg
      841 cctcggcctg cgggatgatc cggcggccgc cctccagctt gatcgcgtgg gcgccggtct
      901 ccttgaggaa ccgggtggcg gccgtcagcg cctcggtgac gccggtctgg taggagccga
      961 acggcaggtc ggcgacgacc atggcgcgct tggagccgcg gacgacggcc gcggtgagcg
     1021 ggatcaggtc gtccacggtg acgggaatgg tcgagtcgta gccgtagacc accatcgcgg
     1081 cggagtcgcc gacgagcagc acggggatgc cggcctcgtc gaagatccgc gcggtgagcg
     1141 cgtcgtaggc cgtgagcatc ggccacttct cgtgccgctg tttcgccgcg gcgatgtcgc
     1201 gtacggtcac cctgcgcccg ctcgtaccgc cgtagagtgc ggtcggctgt gccgggggtg
     1261 cgacagaaga agacatgcag aacctccgct ggtcttgagg cgccactgtg gcgtacccag
     1321 acgaaaccga tggtgccacc tggccaacga ttcggatacc cctccccatt ccagaatttc
     1381 tccgccgggc cgggaacaga ttccgaaacg ataccgttgc gtatcgacat ggacccccag
     1441 acgatccagc gccgccggtg gtacatcctc ggcgtcctga ccatgagcct gctggtggtg
     1501 gtgctcgaca acaccatcct caacgtcgcg ctcaagacca tcgccgaccc ggacaagggc
     1561 ctcggcgcca cccagagcca gctcgaatgg gcgatcaact cctacacgct ggtcttcgcg
     1621 ggcctgctgt tcaccttcgg ggtgatcggc gaccggatcg gccgcaagcg cgtgctcgtc
     1681 ggcggcatgg cggtgttcgc cgtcgcctcg ctggtgtcgg cgtacgcgca gtcgcccgag
     1741 cagctcatct acgcccgcgc cctgatgggc ctcggcggcg ccgcggtcat gccgcagacg
     1801 ctgtcgatca tcaccaacgt cttcgaaccg cacgagcgcg cccgcgccat cggcatctgg
     1861 gccggcgcgg tcggcctcgg cgtcgccatc ggcccgctca ccggcggcct gctgctcgcc
     1921 cacttctggt ggggctcggt cttcctcatc aacgtgccgg tcatcgcggt cggcgtcacg
     1981 ctgatggcct tcctcgtccc cgagtcgcgc aaccccgccc ccggccggct cgacccggtc
     2041 ggcgtggtgc tgtcggtcat cgggctggtc gtcctgtcgt acgggatcat ccagggcggc
     2101 gagaggggtg actggctgga gctctccgtg ctcggcccga tcctcgccgg cgccgccgtc
     2161 ctcgccctgt tcgtgtggca cgaggcccgc accgtctcac cggcgttcga cgtcaggctg
     2221 ttcaaggacg cgcgcatgtc ggccgccgtc gcgtccatcg cgctgtgctt cttcgccgcc
     2281 accggcgtgt tcttcttcgc caacttctac atgcagtcgg tgcgcggtct gacgccgctg
     2341 cagtccggcg ccatggtgct cccgttcgcg gtcgcgcagc tcgccttcgc cccgcgcagc
     2401 gccgccatgg tgcgccgctt cggcgccaag gcggtctgca cgatcgggct gctgctggtc
     2461 agcgtcgcgc tggcgagcta ccagttcgtc ggcgtccaca cctccctgtg gatcctcggc
     2521 gcgatcttct tcgtgcaggg cgccgggatg gccaacgtga tgccgcccgc gaccgagtcg
     2581 gtcatgtcgg cgctgccccg cgagaaggcc ggcgccggat cggccatcaa caacaccgcc
     2641 cgccaggtct cggtcgcgat gggcgtggcc gtgctcggct cggtcgtcgc ctcggtctac
     2701 cgcggagacc tgcgcgacga gctcgccgcg ctgcccgccg gcgcgcggca ggccgccgcc
     2761 gagtcgatcg agggcgcgca cgccgtcgcc gcccagatgg gccccgccgg gcagggcctc
     2821 gtcggccccg ccgacgccgc cttcgtgcac gccatgcacg ccgcgtccgt cgccgcggcc
     2881 gtgatctcct tcctcggcgc cctggtcgtc ctgaagtgga tgccgggacg cgtcgcggcg
     2941 ccgcccgcgc aggcgcccgc cgagcggcgg ccggagaagg cccccgtgtg acggggccgg
     3001 tgtggcaggg tgaggggatc atgaccgaga ccgagcggcg gcaggcgggg cggcctcgca
     3061 gcgagcgcgc cggcaaggcc atcgtcgagg ccaccctgga cctgctggcc gaggagtcgg
     3121 gggtggcggg cgtctccatc gaggcggtcg ccgcccgcgc cggcgtcggc aagacgacga
     3181 tctaccggcg ctggcccagc aaggaggcgc tgatcgtgca cgcgctcggc gccgtgaagg
     3241 agccgctgcc cgagccgtcc ggcgcgtccg cccgcgagga cctcaccgtg atcgcgcggc
     3301 ggctcgcggg cgaccggcac cgccggtact cgcggtgctt ctggaacgtc gtcggcggcg
     3361 cggagaagca ccccgagctg tacgcccgct accggcagga ggtcatcgag ccgcggcgcg
     3421 acgtcatccg cagggtgatc cggcgcgggg tcgactccgg ggagctgcgc cccgatctcg
     3481 acgtggaggt cgcgatgtcg ctgctgctcg gctcgctgac cgccaaacgg ccgcaggaga
     3541 cgttccccga ggggtacgcc gaggcggtcg tcgacaccct cctcaggggc atcgagagcg
     3601 accgggagac ccgtccagag gcggacatcg ggcggttttc ggcgcggtaa gcgcgatctt
     3661 ctccccctac cgcggagtca tgccccatac tgtcgctggg tagtgctgag acgaccggct
     3721 gtctggagcg cgtcaggtga gatccgtcat ggcgccgcga ggcgatgcgc cagccaccga
     3781 ttcggcgtcc cggacccttg tcctgggcat cgacggtgct cggcacatcg tgcagtgcgg
     3841 ccccaacgcc aaggccgtcc tcggccgtgc ccccgaggag ctgatcggcc gccccgccac
     3901 cgacctggtc ggcgacgagg cgaaggccga gctggagacg ctcctggagg ccaacggcgg
     3961 cgggcaggag cgcaacggcg tgatgggcgt gctgcgcggc gacggcggcg cccccgccga
     4021 cgccctcctc accgtgcagc cgatgctcgg cggcagcacg ggcgcggcgc ccgccgcgct
     4081 gctgttcatc cgggtggagc tgccgccgag cgagcgctac caggacccgg ccctcatgcg
     4141 gcgcgccctg atggacgacc cgctcacccg gttcggcgcg acgctcgacc tcgaccagtc
     4201 cgcccgcggc ctcgtcgacg tcgtcgtccc gcacttctgc aacgtcgcgt cggtgctggt
     4261 gctggagagc ctggtcgccg ccgacgaggt gcacgccgag tccggctcgg cggtgctgcg
     4321 ccgcatcgcg gtcacctccg acgacggcaa cccggcctgg acgtccacgt tccccgtcgg
     4381 cgaggtgctc gtcttcccgg agggcacccc gtaccggcag gtgatggaga ccgcccggcc
     4441 cgtccacctg ccgcacatcg cggtggacgc cgcgagcgag atcggccggc tctggcggcg
     4501 cggcccggcg ggcgagctgc tgtccaacgt gtcgatggtg ctgctgccga tgatcgcccg
     4561 cgacacgctg ctcggcttca tcgcctgcac ccgcatcccc ggtttccgca agttcgacgc
     4621 ctacgacgtc gagatcggca tggagttcgc cgcccgcgcc gccatcgtca tcgacaacgc
     4681 ccggcgctac agccgcgagc gggccaccgc gctcgctctg cagcgcagcc tgctgccgat
     4741 gcggctgtcc gcgccctcct cggtcgaggt ccggcaccgc tacctgccgg gcagcaagct
     4801 cgtcgaggtc ggcggcgact ggtacgagtc gatcgcgctg cccggcgccc gcgtcgccct
     4861 gatcgtcggg gacgtcgccg ggcacggcgt ccgcgccgcc gtcaccatgg ggcggctgcg
     4921 caccgccctg cacacgctcg cgaacctgga gctgccgccc gccgacgcgc tgcacgtcat
     4981 gcacgagctg atgatcgagc tgggcgagca ggagccgcac ttcgccacct gcgtctacgc
     5041 ggtgtacgac gcgaccaccg gcaccatcga gatcgcctcc gccgggcacc tgccgcccct
     5101 gctggcgagc ccgaccggcg acaacgagta cctggaggtc ccgcccgccc cgccgctcgg
     5161 cgtctcgggc ggctcggcca tcgagagccg cgagttcccc gtcgaggacg gcagcctctt
     5221 cgtcatctac accgacggcc tggtcgagaa ccggggccgc gacatcgacg acggcctcgc
     5281 ccgcctccag aagatcttcg ggcgcgactc ggtcgaccgt tccatggagg acctcgccaa
     5341 gaccaccctc gcgggcgtct acgccgacca gcaccgcgac gacattgccg tcctgatcgc
     5401 ccggctgcgc cgcctccccc cggaccgcta ctcctcctgg acgctgcccg ccgacccggc
     5461 cgccgtccgc cgcgcccgcg gcctcgtcag cacccgcctg gcggaatggg acctggagga
     5521 cctcgactac accaccgaac tgctggcgtc cgagctcatc accaacgcgc tccgctacgc
     5581 gcacggcccc atcgagctgc gcctcctgct ggagcgcacc ctcgtcctgg aggtcctgga
     5641 ccgctccgcc gcactgccgc gcctgcgccg cgccgaggac gacgacgaga acggccgcgg
     5701 cctcctggtc gtcagccagc tcgcccaccg ctggggcagc cgccgcaccg cagcgggcaa
     5761 ggtggtctgg tgcgagcaga tcgtccccgg cgtcgacccc gacgcctcgg aacaggtccc
     5821 cgcctggccc gaagaggcct ggcccggcga actccaccac cgcgagtaga gctgcccacc
     5881 cagggccgcc ccctgggcta actcagcttt tcccgccagc ggttggtgat ggggagtcgg
     5941 cggtcgcggc cgaagttctt gggcgtgatc ttggggccgg gcgggtactg gcggcgcttg
     6001 tactcggcga tgtcgacgag gcggatggcg cgttcgacca gggccgggtc gtggccggcc
     6061 ttgacgaggg cgtcgcggcc catgtcgcgc tcgacgtagt cggtcaggat cgggtccagg
     6121 acggcgtagt cggggagggt gtcgcggtcg cgctggtcgg ggcgcagctc ggcggacggc
     6181 tccttgacga tgatggcctc ggggatgggc tcgtgcgcga aggggtgcag gagcggtgag
     6241 tccttgcccg cctgcgcgtt gcgccagcgg gcgaggtccc agacggtgag cttgaagacg
     6301 tccttgatgg ggccgaagcc gcccgcggag tctccgtaga gggtggagta gccggtcgcc
     6361 agctcgctct tgttaccgcc ggtgaggacg aggtggccgt cctcgttgga cagggccatc
     6421 cacacgttgg cccggatgcg ggcctggagg ttctcggcgg cgaggccgtg caggtcgagc
     6481 tgctcctcga acgcctcgac catgccggcg atggggacga tgcgcgaatg gacgccctgc
     6541 cgcttgacga gctcctcggc gtccacgacg gagccctccg aggagtagcg gctcggcagc
     6601 aggacggcgt gcacgtgctc cgggccgatg gcgtcggagg cgatggtggc gacgagcgcc
     6661 gagtcgatgc cgccggacag gccgagcacg acggagcgga agccgttctt gcggacgtag
     6721 tcgcgggtgc cgaggacgag cgccgcgtac acctcggcga ggtcctccag ggggcgcgcg
     6781 accgtccgcg gctccgcggg gtaggcgggc agcgggtcgg ccgacaggac gtgccggtcg
     6841 atggtgatcg tggtgccgtc ctgggcgtcg acgcggacgg ggcccgcctc ggcggccggg
     6901 ccggcggccg gcaggtcgag gtcggtgacg aggaggtgct cgacgaactg gggggcgcgg
     6961 gacaggggcg agccgtccgg gccgacgatg accgagtcgc cgtcgaagac gagctcgtcc
     7021 tggccgccga ccatgttgac gtaggcgagc gcgcagccgg cctcgcgggc gcggccggcg
     7081 cacaggtcga ggcgggcgtc gtccttgtcg cgctcgtagg gggaggcgtt gatcaccagc
     7141 agcagcccgg cgcccgaggc gctcgtgacg ctgaccgggc cgccgtcctg ccagaggtcc
     7201 tcgcagatgg cggtggcgac gtccacgccg tgcagccgga cgaccggcag ccggtcgccg
     7261 cgcgcgaaga tccggtactc gtcgaacacg ccgtagttgg gcaggtggtg cttggcggag
     7321 cggacgagca cctcaccgcg gtgcagccac gcggcggcgt tcagcggcag gccgccgggc
     7381 cggccggggc gggccccgcc ggccggcggg cggtcgaggt agccggtgac gacgggcagg
     7441 tcgccgagcc cttcgtcggc gagccggcgg gcgaggtgct ggagggcgtc gcgggacgcc
     7501 tccacgaagg acgcgcgcag cgcgaggtcc tccacggggt agccggtcag catcatctcc
     7561 gggaatgcga cgaggtgcgc gcccgcctcg gcggcgcggc gcgtccacgt cagaatctgg
     7621 tcggcgttgc cgtcgaggtc gccgacggtc gagttcacct gcgcgagcgc gagcctgagt
     7681 tgtgccacgg tccaagcgta gaacgccgga cccggtttcg tcactttgac gagaagtgga
     7741 cgccgagcac ggcggcccgc cggcgccgga tcgcgggggc gagcgcgagc tgcgccgcgg
     7801 cggcggccag ggcgagagcc gcgcaggtga gccacagtgc gggcgccccg ccggcgccga
     7861 gcagctgggt gccgccgagg ggcgccagca ggaatccgcc cgaccacgcc atcccgtaca
     7921 ggccgccgta ccggccgcgc aggccggcgg gcgcgaggtc ggcgaccacg gcctgcagga
     7981 cggacgcggc gatgatctcc ccgagcgtcc acaccaggat cgtcgcggtg taggcgggca
     8041 cggacgaggc gagcgaggtg agcccgtagc cgaccccgac cagcgcgaag cccgccgcca
     8101 gcaccaggct gtggtcgcgc cgtgccagcc acgcgttcac cagcggctgg acgatgatga
     8161 tcagcacgcc gttcgccgcg atcgccaggc cgtaggaccg cgggccgagc ccgtcctcct
     8221 tcatggcgag cggcatcgtc gtcatgccct gcatgagcac gaacgtgtag aggagggtga
     8281 ccaggacgta gccgaccatg acccggtcgc gcagcacgcg gccgaacccg cccgtccgct
     8341 cggcgcgggc gtcgcgggtc cgcgtctccg ggatcgcccg ccacacgagc aggccgaacg
     8401 ccgcgcaggt gagggcgtcg atccagaaca gccacaggaa gccctgctgc gcgagcgtcc
     8461 cgccgagcac catggcgacc gcccagccga ggttgatcgc ccagaacagc agcccgaacg
     8521 cgcgggggcg gtcggcgggg gagatgatgt cggccaccat cgcctgcgcg gcgggccggt
     8581 acatgtccag gagcaggccg agcaccagcg cggccgcgag gatcgcggcg agcccctggg
     8641 cgtagccgag cgcgagcatg gccgcgccgg tgccgacggt cgcgagcgtc agcgtcgccc
     8701 ggcggccgat gcggtcggcg agcatgccgc cagcgagctg cccggcgagc gagcccgcgc
     8761 ccagcacggc catcgtcacg cccgcctggg tcagcgacag cccgcgcatg gtcgtcaggt
     8821 agaggccgag gaacggctcg accatggttc cgaggcggtt gagcagggtc cccgcccaca
     8881 gcacccagaa gggccggggg aagccgccga ccctgggccc gaggaacgcc gcgaacctgc
     8941 cgggagcggg cccgacaggg gtcttttcca gagtgctcac tcgcacgatg gtgggggcgc
     9001 cgcgcgctcc gagacattca tttagcctgg gctaaatgat cgagttcgtg ctggcgccgg
     9061 acgacgtggc gcgggtccgg ttcgcgttct cgccgctgtg ggagatggtg cgcagcctgc
     9121 gggtgctcgc cgacccgtcc ggccacgcgc tccacctgcc gtgggtgcgc acggtccggc
     9181 cccgcctgcg cggtctcggc ttcgagccgc tgctggacgt cgtcctgccc gccgggtaca
     9241 tcccggactt cctcaccccg ccgccgcgca cgccgctgcc cgacctcggc gcggagctcg
     9301 cgaccgtccg cgccaccccg cccgaggtcg tcgccgccga gctcagctgg accgcgcccg
     9361 gagcccggcc ccgatccgcc cgccgcgccc tggccgccga ccccgaaggc accctggaaa
     9421 ggctcgccga cctgctcgaa cggtactggg aggtggccgt ggagccgttc tggccgcgca
     9481 tccgcgacct cctggagggg gaggtcctgc gccgcagcgg cgcgctcgcc gccgagggcg
     9541 ccgagggcgt gttcggcgac ctgcacgagg cggtctcctg gcgcgccggg acgctttccg
     9601 tcgaccgcca ctgggacttc cgcggcgagc tcgccgggcg cgggatcctg ctcgtcccga
     9661 gcgcgtacgt gtggccgaac gtgtcggtga tggtgccgcc ctaccagccg atgctcagct
     9721 acccgccgcg cggcgtggcg acgctctggg agaccgggcc gccggacgag ccgcgcgccg
     9781 gggccctggc cgcgctgatg ggacgccgcc gcgccgagct gctcacggcg ctctccacgc
     9841 cggcgtccac caccgacctg gccaggcggg cgggcgtgac cgcgggggcc gtcagccagc
     9901 atctgggcgt cctgcgcgcc tgcggcctcg tcaccgggca ccgcatgggc cgccgcgtgc
     9961 tgtacgtccg cacgccggcc ggggacgccc tggccggcgc tcagcgcagc gacgcgagcg
    10021 cgtccaggcg cgacggcccg ggggaggccc ccgggccgta gcggccggac tcggcgagcc
    10081 agtccatgtg cgcgcgcggc gtgtccagca ggaccttgac gacctgcgcg gcggcggcgc
    10141 gctgcgcgac cgtcaggtcc agccggtcga gcatctccgg cagccggcgc gccgccgccc
    10201 acgcctcctc cagccggtcg gcgatccggt cggcgaccct gtgggccgcc cgcgcctcgt
    10261 ccagcccgtg cgccctggcg aggacggcgg gcaggtcgtg cacgtcgccg cgcgcggcct
    10321 ccaggtcgtg cgaggcgaga tcgttcgccc aggccaccac gtcggcgatg ccgtcggcga
    10381 gggtcttcca gcgtggcgtg cgcagcagcc gcgccggcag ctcgactccg aggacggcct
    10441 cgacgaggtc gaacaggaag ggcccgcacg cgcggcggcg cagcgccggg tactcctgct
    10501 cggtcgggac gtggctgatc cgccggttga cggcctcctc ggcgcagccg tcgcggtgcg
    10561 cctccaggtg cagcatgaac cggcggcgcc agtcgcggct catgtccttg gacgtggcct
    10621 gccacagctc caccagcgcc gcctccagcg gccgggcgcc gggccgggcg tggccgcgcc
    10681 gcatcgcgcg cagcaggtcg tcgtacaggg cgtgcacggc gctgccgctg tcggcgagcg
    10741 gcgggtggtc cagcgtgtcg tccagcgcga gcgtccaggt cagccagcgg gcgaacaggt
    10801 ccacggcggc caggtcggcg gacggcagga cgcgggcggc cagccgttcg cagcgcgccc
    10861 ggccgagcgg ggaggtgtcc ggatctccga gcaccagccc gcggccgcgt gcccaggcct
    10921 ccacctgcgc gcacagctgc cacgactccg ggtgcatggc cgacggtgtg gccagcgcgg
    10981 tcacccggtc ggtcatcgag agaagaagtg agatgtccac gacgtgatcc acgctaacga
    11041 tcaccgtgcc gggcgaccat gatcgccacg tcaatttccg ggaaacggat atccggggac
    11101 ggtcatgggc gagtcagccg cccgcccctg cccacggcgg gagggacgtg cgatagtgcg
    11161 gtgatcggaa gccagcacga tcaggaggaa acgtgtcgag acggacgaca ctccgggcct
    11221 tcggcgcggg gctcgcggcc ctggcgctga cagcgtcggc gtgcggcggg gacaagggcg
    11281 cgacggtgca gggcgtgaag ctcatcgaga agggcgcgct cacctcgtgc acgcacctgc
    11341 cctacccgcc cttccagtcg gaggacaaga agtcgggcaa ggtcgtgggc ttcgacgtcg
    11401 agctcatcga cctcgtcgcc aagcggctcg gcgtcaccca gaagatcgtc gacaccccgt
    11461 tcgagacgat gaagacgggc tcggcgctga acgccggcaa gtgcgacatc cagatgggcg
    11521 gcatgacgat caagcccgac cgggtgaagt tcatggacgt ctccaccccc tacttcgacg
    11581 ccacgcagtc gctgatggcc aagaagggca gcgggatcac cacgctcgac gacgtcaagg
    11641 ccaagaagct caagctcggc tcgcaggcga gcacgaccgg cgaggacttc gtcaagggca
    11701 agggcttcga cccgcgctcg ttcgacaact ccaacgccga gctggacggc ctgcgcaccg
    11761 gccaggtgga cgtgatcgtg caggacgatc cggtcgtgaa gggctggctg aaggacccgg
    11821 cgaacgccgg cttcgagatc gccgcgaacc tgaacaccgg tgagcagtac gggttctgga
    11881 tgcgcaaggg gcacaacccc gaactggtga agatgaccga ccaggtgatc gcgcaggcga
    11941 agtcggacgg ctcctacaag cggatctacg agaagtggat cggtccaatg ccgcccagcg
    12001 ccggcggcgg ctcgtgaccg cggaaccggc cggggtggcg gcgccgggcg ggctgacccg
    12061 ccggcgccgc cggcagctct ccctcggcgg ccagtacggg atcttcgccg tcgtcgtggt
    12121 gctggtgctg gggctcgccg actggggcac cctgcggctc aacttcgcca actgggacgt
    12181 cgccaagagc ctgttccccg acatcatcac ggtcgggctg cgcaacaccg ccgtctacac
    12241 cgcggtcggg ttcgggatcg gcctcggcgg cgggctggtc gtcgcgctga tgcgtttgtc
    12301 gtcggtgccc ccgtaccggt ggttcgccac cggctacatc gagatcttcc gcggcctgcc
    12361 gctcctgctg atcttcattt tcgtgggcgt cggcgtgccg ctggccttcc cgggcaccaa
    12421 catccccggc ggcgccgccg ggcaggcggg cctggccctc ggcctcgccg ccaccgccta
    12481 catggccgag acgatccggg ccgggatcga ggccgtcccg aaggggcagc tggaggcggc
    12541 gcggtcgctc ggcatgtcgc acacccgcgc gatgcgctcg atcgtcatcc cgcaggcgtt
    12601 ccggatcatc atcccgccgc tgaccaacga gctggtgctg ctctgcaagg actcctcgct
    12661 ggtgctgttc ctcggcatca cgctcgaaca gcgggagctc acgaagttcg gccgcgacct
    12721 cgcgggcgag cagggcaaca ccaccccgat catcgtggcg gggatctgct atctgctcat
    12781 cacgatcccg ctgagcctgc tggcccggcg gctggaggcg cggcagcgca gggggcggcg
    12841 atgacgagcc tcgtcaagga caccggggac ccggcggcgg gaccggcggc catcgagatc
    12901 agcggcctgt acaagtcgtt cggggcgaac gaggtgctgc gcgggatcga cttccacgtc
    12961 ggggcgggtg aggtcgtctg cgtgatcggc ccgtccgggt cgggcaagtc gacgctgctg
    13021 cgctgcgtca acctgctgga ggagccctcc gccgggacgg tccgcgtcgc cggcgcggac
    13081 gtcaccggtc ccgaggtcga catcgacgcc gtccgccgcc ggatcggcat ggtcttccag
    13141 gcgttcaacc tcttcccgca cctgaccgcg ctcggcaacg tcatgatcgc ccagcggaag
    13201 gtgctgaagc gggggagggc ggaggccgag cggatcgccc gggagaacct ggagcgggtc
    13261 gggctggccg acaaggtcga cgcctacccg gcgcagctgt cgggcggcca gcagcagcgc
    13321 gtggccatcg cccgcgcgct cgcgatgggc ccggaggtga tgctgttcga cgagccgacg
    13381 tccgcgctgg accccgagct ggtcggggac gtcctcggcg tcatgcgcgg cctcgccgag
    13441 gccgggatga cgatgctcgt cgtcacccac gagatgagct tcgcccggga ggtggccgac
    13501 cgggtggtgt tcatggacgg cggcgtggtc gtggaggagg gcccgcccgc ccaggtgatc
    13561 ggcgagcccg cgcacgagag gaccaggacc ttcctttcgc gcgtcctcga cccggcggcg
    13621 gcgcggatcg aggacggtcc gcggtcggat atgttccgat caccggcccc ggacgcgtaa
    13681 cgtcgcggta acagcgtccg ggcatactgc agatacagcc ggaccggctc cacacggccg
    13741 gcatgccgga cccgcgtcgt cgacaacgca gtctcgccga cagggcagta ccgagggaga
    13801 gggcattgga ccgtcagcag gagttcgtgc tccgcacgct ggaggagcgc gacatccgct
    13861 tcatccggct gtggttcacc gacgtgctcg ggttcctgaa gtcggtggcc gtcgcccccg
    13921 ccgaactgga gggcgccttc ggcgagggca tcggcttcga cggctcggcg atcgagggct
    13981 tcgcccgggt ctacgaggcc gacatgatcg ccaaaccgga tccgtccacc ttccaggtgc
    14041 tgccctggcg gtcggagtcc ccgggcgtcg gccgcatgtt ctgcgacatc ctcatgccgg
    14101 acgggacgcc gagcttcgcc gacccccgct acgtcctcaa acgctccctg gcgcgggccg
    14161 ccgacctcgg gttcaccttc tacacccacc ccgagatcga gttcttcctc ctcaacgaca
    14221 agccggagga cggccgcgag cccgagccgg cggacgcggg cggctacttc gaccacaccc
    14281 cgcacagcgc cgcgcacgac ttccggcgca acgccatcac gatgctggag gcgatgggga
    14341 tctcggtgga gtacagccac cacgagggcg cccccggcca gcaggagatc gacctgcggt
    14401 acgccgacgc gctcaccacc gcggacaaca tcatgacgtt ccggctggtc atgaaggagg
    14461 tcgcgctgga gcagggcgtg cacgcctcct tcatgccgaa gccgtacacc gagcacccgg
    14521 gctcgggcat gcacacgcac atgtcgctgt tcgagggcga ccgcaacgcc ttctacgagc
    14581 cgggcgcgga gttcaagctg tccaaggcgg ggcgggcgtt catcgccggg ctgctgcggc
    14641 actccgccga gatcaccgcc gtgtgcaacc agtgggtcaa ctcctacaag cggctgtggg
    14701 gcaacgtcgg ctccgcggcg ggcctggggg gagaggcccc gtcctacatc tgctgggggc
    14761 acaacaaccg gtccgcgctg gttcgcgtcc ccatgtacaa gccgcacaag ggccactcga
    14821 cccgcatcga gttccggtcg ctggacaccg ccgccaatcc ctatctggcg ttcgccgcga
    14881 tcctcggcgc cgggctcaag ggcatcgagg agggctacga gctgccgccg ggcgccgagg
    14941 acgacgtctg ggccctcacg gtggccgagc ggcgcgccct cggcatcgag ccgctgccgc
    15001 agaatctgga cgaggccatc cgcgcgatgg agcgcagcga gctgatggcc gacgtcctcg
    15061 gcgagcacgt cttcgacttc ttcctgcgca acaagcgcca ggagtgggag gactaccgcc
    15121 gccaggtgac cgaattcgaa cggaagcggc tgctggccgt cctctgatgg cccgcgccgg
    15181 attacggttg gtcctgtgac cgagtcctgg acttccgacc gccgtccctc gctcgccgga
    15241 cgcctggcgc ggctcgggtt cacccacgcg gcgcgggcgg agcggctgct cgcggaggcc
    15301 gagcgggacg gcgccggacc gggcgacggc ctgctcgacg ccctcggcgg caccgccgac
    15361 cccgacctcg ccctggacgg tctgctgcgc ctgctccccg ccgcgggcgg cgggctgcgc
    15421 gcggcgctgg ccgccgagcc ggggacgcgg gagcggctga ccgcggtcct cggggtgagc
    15481 gcggcgctcg gcgaccacct ggcgcggcac ccggaccact ggcgggtgct gcgcgacggc
    15541 gtcgcgggcc cgctcgggag tccccgcgcc gacctgctgt ccgccgtggg cgccgacccg
    15601 gcggcgccgg aaccggtggc gcgcggcgag gacgcgctcg tcgcgctccg cgtcgcctac
    15661 cgccgccgcc tcctggcgct ggcgggacgc gacctgatcg gcgcggcgga cgtcgccgag
    15721 gtcgccgccg aactggccga cctcgccgcc gccgcgctgg aggccggcct cgcgatcgcc
    15781 cgcgccgagg tccccgggca cgaggcgtgc cggctcgccg tgatcggcat gggcaagtgc
    15841 gggggccgcg agctcaacta cgtcagcgac gtcgatgtga tcttcgtggc ggaagcgcgg
    15901 gagggacggg acgaggacgc cgcgctgcgc accgcgaccc ggctggcgtc ggcgatgatg
    15961 cgggcctgct cggccacgac cgaggagggc gcgctctggg aggtggacgc ggcgctgcgc
    16021 cccgagggca ggtccgggcc gctcgtgcgg acgctcgcca gccaccgcgc ctactacgag
    16081 cggtgggcca agacgtggga gttccaggcg ctgctgaagg cccgtcccgt cgcgggcgac
    16141 gccgacctcg gcgcccgcta cctcgaaacg atcaccccga tcgtgtggaa ggcggccgag
    16201 ggggagagct ttgtcgagga cgtccaggac atgcggcgcc gcgtcgaggc ggacctgaac
    16261 cagcgcaccg ccgactccga gcggcagctc aagctcgggc cgggcgggct gcgcgacgtc
    16321 gagttcgcgg tgcagctgct ccagctcgtg cacggccgcg ccgacgagac gctccgcagc
    16381 ccgaccacgc tggacgccct ggccgacctg tcccggggcg gatacgtcgc gcgcgacgac
    16441 gcggcggcgc tggcgtcggc gtaccggttc ctgcggcgcg tggagcacct cgtccagctg
    16501 caccggctgc gccgcaccca cctcgtcccg gacgacgagg ccggcctgcg ccgcctcggc
    16561 cgcgccctcg gcctgcgcac cgacccggtg ggggagttca ccgcgctgtg gcggcggcac
    16621 gcccgggagg tccgccgcat ccacgagaag ctgttctacc ggccgctgct gcgggccgtc
    16681 gcacggctgc ccggggagga ggcccggctc acccccgagg cggcccgggt ccggctggag
    16741 gcgctcgggt acgccgatcc ggcgggcgcg ctgcggcaca tcgaggcgct gaccgcgggc
    16801 gtgtcgcggc gggccgcgat ccagcggacg ctgctgccgg tcatgctcgg ctggttcgcc
    16861 gacgcgcccg accccgacgc gggcctgctc gggttccggc aggtcagcga cgccctcggc
    16921 accacgccct ggtacctgcg gctgctgcgc gacgaggtga ccgtcgccga gcggatggcc
    16981 tgggtgctcg gctccagccg ctacgccacc gacctgctgc tgcgcgcccc cgaggcggtc
    17041 gccctgctgg gcagcgacac gggcctggcg ccgcgcccgt acgaggcgct gcgcgcggag
    17101 gcgctcgccg ccgtccgccg ccacaaggag gggaccggcg ggaagcccgg ggaggagggg
    17161 cgggcgggcg cccgccccgc cgaggaggcg gccggggtgg tgcgggcgct gcggcgccgc
    17221 gagctgttcc gggtggccgt cgccgacctg ctcggcctcg tggacgtccg ggaggtgggg
    17281 gaggccctca ccggcatctc caccgtcacc gtcgaggccg cgctccagct cgccgtcaac
    17341 aagatcgaga tggagtcgcg cgggccgctg ccgacccgga tggcggtcgt cgctatgggc
    17401 cggttcggcg ggcacgagct cggctacggc agcgacgccg acgtgatgtt cgtccacgac
    17461 ccgctgcccg gcgcggacga gggcgccgcc gggcgggccg cgtacgccgt cgccgaggag
    17521 ctgcgccgcc tcctcgccct gcccgccccc gacccgccgc tggtgatcga cccgaacctg
    17581 cgcccggagg ggcggcaggg gccgctcgtg cgcacgatcg cgtcctacgc cgcctactac
    17641 gcgcgctggt cggagccctg ggaggcgcag gcgctgctgc gcgccgaccc gatgatcggc
    17701 gacccggggc tgtgcgagcg gttccgcgcg ctgatcgacc ccgtccgctg gccggaggac
    17761 ggcatcgacg aggacgccgt ccggcagatc cggcggctga aggcgcggat ggagtccgag
    17821 cggctcccgc gcggcgtcga gcggcgcctg cacaccaagc tcgggccggg cgggctcgcg
    17881 gacgtggagt gggtcgcgca gctgctccag ctgcggtacg cccacgaggt cccggcgctg
    17941 cgcaccaccc gcacgctgga cgcgctggac gccgcggtcg aggcccgcct cctggacgcc
    18001 gaggacgccg agaccctggc cgaggcgtgg tgcatggcca cccgggtccg gggctcgctc
    18061 atgctggtgc ggggccgcgc gtccgacctg ctgccgaccg accaccaccg cgagcgcagc
    18121 tccgtcgccc gcgtcctcgg ctaccccggg acgggcgacc ttctggagga ctaccgccgg
    18181 cacgcccgcc gtgcccgcct cgtcgtggac cgcgtcttct acggagccga gtgagccccg
    18241 gagccgcccg tgcgccgtcc ggtccgctgg tggaaccggt gcatgacgcg ggccctggcg
    18301 atgaggagcg gtgcggggca gcgcgtgtag aggatccacg aggcccacag cgcgccgccg
    18361 atgaccgcca tgcccgccac cgcgtccagc acgtagtggt tggcggtgga caggatcacg
    18421 atcacggtgg tcgcggggta gagcacgccg aggagcttgg cccacctctg cgacgccagc
    18481 ctgaccagca ccagcccgca ccacagcgac catccggcgt gcatggacgg catggccgcg
    18541 tactggttgg tcaggctccc ggacgcatcg ctggcgtaca ggccgagcga gtgcagcgcg
    18601 gtcaccgggt cgacgaagcc ctcgctgtgc aggaacctcg gcggcgccag cgggtacagc
    18661 cagaagccga tcagcgccac accggtggcg atcatgatgg aggtgcggag ccaccggtag
    18721 tgctgcggcc ggtagcggta cagccagacc acggtggcga gcgtcacgat gaagtgcatc
    18781 gtggcgtaga agacgttcgc ggtccgcgcc agccacggca cggtcagcag cgtctggttg
    18841 aggtgcagct cgacgtccag ccccagaaag cgctcggcgc gcaggatctc gtcggcgtgc
    18901 gcgaacgccg gcccggtgcc gtcctgaacc aggacgatcc gcgtcagcgt atagccgctg
    18961 tagaacagga cgaccagcag gagctcgcgc cagacggggg gcgcggtgat gacccggcgc
    19021 cgcattccgg tggcgccggc ctcgcttctg cgggccgctg ggggggcgga ttgagccatg
    19081 ctacctatct ttgccgccgg ggccccgaat gagatcaccg cgacgaatgg tcttcatctc
    19141 agacctgagt agtacgaccc tgacgcggta tccggacttt cgggggagga cctcagggac
    19201 gccgggggat cccggcgccg cccgcccctc ccacggagcc cgttgagccg atcaggagtc
    19261 ggcgtcgagg gccatgggta ggtcccgatc gcttcaggcg atgcgatcgg agggacgaat
    19321 ggccaggtat cgggggatat caggcgcggt gccggcgggt gccgcgaccc tggccgcctt
    19381 aacgctcgtc tccctctccg gggggacggg ccacgcgcgc acgtcgcccc gcgcggcgac
    19441 gggcaccgca cccgcggcga ccgacacctc gcccgtggcg gctccccggc tgtcgtgggg
    19501 gcgctgcacc ggcctgccgg ccccgccgcc cgggagcaaa ccgccccgcg ggctgcgctg
    19561 cgcggcgctc ccggtgccgc tcgaccacgc ccggccctcc ggcgagaaga tcgaactcgc
    19621 cctgatcaag gtgccggcga ccgacccgcg ccggcgcatc ggctcgctgg tgttcaactt
    19681 cggcggcccc ggcggagagg gcgtcgacac gctcgcgcag gccgcgggcc agtacgccgg
    19741 cctgcgcgcc cgctacgacc tgatcggcct cgacccccgc ggcgtcggcc ggagcagccc
    19801 ggtggcctgc gtggacgacc gccgcatgga cgcgatcgcc gccatggacg acagccccga
    19861 caccgccgcc gaggagcagg cgtacacggc cggccgcgcc gactacgtcc gccagtgcga
    19921 ggcccggtcg gggcggctgc tgccgcacgt cggcaccgcc gacgccgccc gcgacctcga
    19981 cacggtccgc gccgccgtcg gcgacgagcg gctgcactac ttcggcatct cctacggcac
    20041 ctggctcggc gccagctacg cgcaccagtt ccccgccagg gtggggcggg ccgtcctgga
    20101 cggggccgtc gacaccagac tcggccgcgt ggacctggcc ctccagcagg cggccgcgtt
    20161 tcagcgcgcc ctcggcggct tcggcgccgc ctgcgcgcgg ctcgggaaga agggatgccc
    20221 tctcggcacc gacggcccgt ccgtcgtggc gtccatcggg cgcttcctgg ccgggctcga
    20281 ccagagcccg ctccgcacct cgtccggtcg ccggctcacc cagagcctcg gcaccgccgg
    20341 cgtcgccgcc gcgctctact cccgggacgc ctggccgtac ctcgcgcagg gcctggtcga
    20401 cgcggtgaag cgccgcgacg ggtcgctgct gctgatgctc gccgacgtcc agaacggtcg
    20461 gcggcaggac ggcacctaca gcaatctctc tgccgccaac accgccatca cctgcgccga
    20521 cggcgccgac cgacccggcg cgaccgacgt gcggcggctg ctgccgcggt tccgcgaggc
    20581 ctcgccgatc ttcgggacgt cgctggcgtg gggcctgctg cagtgcacgg gctggccggt
    20641 acggggcgac gccgccgcgc gcgaggtgtc cgccccgtcc gccgcgccga tcctcgtcgt
    20701 cggcaacacc ggcgaccccg ccaccccgta cgcgtgggcg tccgcgctga cggacgcgct
    20761 cggcgggcgg gccaccctcc tcacgctcaa gggcgagggg cacggctcct acgacaccgg
    20821 cgacccctgc gtccgcgagg ccgtgcacgc ctacctcctg cgcggcacgg tgcccgcccg
    20881 gggggcgacc tgcggctagc gagcggtctc cggcacccgg ccgacaccgg gtgccgccgc
    20941 gcccgcgccc ccgtcacacg atctgctcga ccttcatcgg ctcccgcaga gcgctgccga
    21001 ctgtgcagta cttctcgtgg
//
