LOCUS       NZ_BMQY01000002        21784 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Couchioplanes caeruleus subsp. azureus strain JCM 3246 sequence02,
            whole genome shotgun sequence.
ACCESSION   NZ_BMQY01000002
VERSION     NZ_BMQY01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Couchioplanes caeruleus subsp. azureus
  ORGANISM  Couchioplanes caeruleus subsp. azureus
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Couchioplanes.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 909631)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 64X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:32:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,801
            CDSs (total)                      :: 6,731
            Genes (coding)                    :: 6,630
            CDSs (with protein)               :: 6,630
            Genes (RNA)                       :: 70
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 101
            CDSs (without protein)            :: 101
            Pseudo Genes (ambiguous residues) :: 0 of 101
            Pseudo Genes (frameshifted)       :: 20 of 101
            Pseudo Genes (incomplete)         :: 93 of 101
            Pseudo Genes (internal stop)      :: 0 of 101
            Pseudo Genes (multiple problems)  :: 12 of 101
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:23:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 807054
            Orig. end                         :: 828838
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMQY01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21784
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="5"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21784
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21784
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11784]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11784
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(62..277)
                     /locus_tag="IEY99_RS10780"
                     /old_locus_tag="GCM10010166_21550"
     CDS             complement(62..277)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY99_RS10780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010166_21550"
                     /product="hypothetical protein"
                     /protein_id="WP_189201892.1"
                     /transl_table=11
                     /translation="MTLFDFEGDDVEVEPRPPLCRYLAAQGTAFATLVAFLVILVLAVA
                     ALVGACVSDVPGLAWLAALVTRPFVA"
     misc_feature    248..262
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            482..853
                     /locus_tag="IEY99_RS10785"
                     /old_locus_tag="GCM10010166_21560"
     CDS             482..853
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014444332.1"
                     /locus_tag="IEY99_RS10785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21560"
                     /product="YciI family protein"
                     /protein_id="WP_189201894.1"
                     /transl_table=11
                     /translation="MRYALLMHYQEMSEGELSEELLREGQAAFDAYGRALQQAGVLISA
                     DVLQPSAATTTVTRRDGVTQVQDGPFAETKENLAGVFLLDVPDLDAAIGWAEKCPGAQW
                     GTIEVRPTATALVEGGWTR"
     gene            925..2193
                     /locus_tag="IEY99_RS10790"
                     /old_locus_tag="GCM10010166_21570"
     CDS             925..2193
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014444333.1"
                     /locus_tag="IEY99_RS10790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21570"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_229798452.1"
                     /transl_table=11
                     /translation="MAGLAARDSYGRLLALLSASTSDLASAEDALADAFERALRTWPDH
                     GVPGNPDAWLLAVARNRLRDRWKSAESRRTLPLDIEQHAPVHLDDLTIDAIPDRRLELM
                     LVCAHPAIERAVHTPLMLNTVLGFTADQIGRAFSVPTSTMATRLVRAKRRIKAAGIPFR
                     LPDRGELPARMAAVLEAVYGAYVIDWATTGPQERRLPGEALHLAEVLSTLVPDDPEVHG
                     LAALVQLSAARARARIDREGRFVPLADQDPSRWDHRLITRAHEHLRTAHARGQLGRFQL
                     EAAIQAVHCARRQTGTTDWPTLLTLHRLLHTVAPSLGSGVAFAAVTAEVDGPAAGLAML
                     DALLDDAGAHARRFQPARAARAHLLDRLGRSEEAVTAYDSAIDLTHDTAERQYLQHRRD
                     DAGRRVGQRGSAAPRSGPDSGVV"
     gene            2231..2635
                     /locus_tag="IEY99_RS10795"
                     /old_locus_tag="GCM10010166_21580"
     CDS             2231..2635
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018833615.1"
                     /locus_tag="IEY99_RS10795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21580"
                     /product="hypothetical protein"
                     /protein_id="WP_189201898.1"
                     /transl_table=11
                     /translation="MVMTSVTEVEHAIRSGWSPETCDPVDLADWSPANPARGQCGVTAL
                     LLHELLGGRLLLATVLHADGTRQGVHYWNRLGRIELDLTREQFTAGEVVQAPAVVDPPS
                     GPPVRLRAQYLLLHRRVHDALSLTPASPPQ"
     gene            complement(2802..3932)
                     /locus_tag="IEY99_RS10800"
                     /old_locus_tag="GCM10010166_21590"
     CDS             complement(2802..3932)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476429.1"
                     /locus_tag="IEY99_RS10800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21590"
                     /product="MFS transporter"
                     /protein_id="WP_229798454.1"
                     /transl_table=11
                     /translation="MTISLLSGFGGSAMSLVTGVWILDLTGSPGRAGLAGLCVYAPTLA
                     GPWLGAITDRIPRRPLLVATNLVLAAALLSLFAVHSAQQAWLIYLVSFTYGISYVVLDA
                     GESALLPAALAPQHLGTVNGWRSAAREGMKLLSPLAGAGLYAWQGGSAVAALSALMPMI
                     VALLYPLLGLTGSATPAAVERGFRAGLAVLRARPVLRVTVPLAGVSIALSGFSTAPGYA
                     VVTEDMHLPSTFLGLLMSAQGAGSIVAGLTAGRVVSRHGAIAAGAAGTALFAAGLLARC
                     LPWWPAIVAGAVVAGAGLPWTLVAAVTAVQTHTPAHLLGRVSATANTAMFGPIALANPL
                     GSAAVHLGGRPSLIAAAVACLAAAAVATRLRPGTSG"
     misc_feature    3972..3992
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.73"
                     /tool="antismash"
     gene            complement(4037..4516)
                     /locus_tag="IEY99_RS10805"
                     /old_locus_tag="GCM10010166_21600"
     CDS             complement(4037..4516)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018732839.1"
                     /locus_tag="IEY99_RS10805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21600"
                     /product="hypothetical protein"
                     /protein_id="WP_189201901.1"
                     /transl_table=11
                     /translation="MSVLEQLAEIGPARARLEERELELIDRARQAGATWTEVAAALGLG
                     SRQAAEQRRQRLVAAARSRLHHRDLRYAHSIVVLREAVCDLHRAIAADRRWAGRFVRAA
                     LVRDTVAAAVDAPAGGLYALAEQAARDLAAAGAKALPGHVRLAFRKVRQALSTKH"
     gene            complement(4540..5325)
                     /locus_tag="IEY99_RS10810"
                     /old_locus_tag="GCM10010166_21610"
     CDS             complement(4540..5325)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (24-190). E-value: 1.7e-14.
                     Score: 46.0. Matches aSDomain:
                     nrpspksdomains_IEY99_RS10810_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014691230.1"
                     /locus_tag="IEY99_RS10810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21610"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_189201903.1"
                     /sec_met_domain="adh_short (E-value: 6.4e-31, bitscore:
                     103.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSNVLTEEHRSDQAAGPEPVAGKTVLVTGGSTGIGRATAILLAS
                     AGAQVVIVGRHQRELDDAVHDIERAGGQVVALQADLTESADIQRIFAEIDSRLDGLDVV
                     VTNAALGAGSIVDGTYDEWSYVVRTNFLGYLAVCHEAIARMRTCGRGHIVCLGSMSADV
                     REEGSSVYVATKAGIQGFAEALRKEVNPLGIKVSLIEPGAVGSDMQADEFSPEQQREQI
                     EQLKMLRAEDIAACVLYVLTQPRRCDVVDVKIRPHRQEI"
     aSDomain        complement(4756..5253)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY99_RS10810_PKS_KR.1"
                     /evalue="1.70E-14"
                     /label="IEY99_RS10810_PKS_KR.1"
                     /locus_tag="IEY99_RS10810"
                     /protein_end="190"
                     /protein_start="24"
                     /score="46.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLVTGGSTGIGRATAILLASAGAQVVIVGRHQRELDDAVHDIER
                     AGGQVVALQADLTESADIQRIFAEIDSRLDGLDVVVTNAALGAGSIVDGTYDEWSYVVR
                     TNFLGYLAVCHEAIARMRTCGRGHIVCLGSMSADVREEGSSVYVATKAGIQGFAEALRK
                     EVN"
     CDS_motif       complement(5161..5253)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY99_RS10810_0001"
                     /evalue="2.80E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="IEY99_RS10810"
                     /protein_end="55"
                     /protein_start="24"
                     /score="20.0"
                     /tool="antismash"
                     /translation="TVLVTGGSTGIGRATAILLASAGAQVVIVGR"
     gene            complement(5322..7592)
                     /locus_tag="IEY99_RS10815"
                     /old_locus_tag="GCM10010166_21620"
     CDS             complement(5322..7592)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY99_RS10815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010166_21620"
                     /product="hypothetical protein"
                     /protein_id="WP_189201904.1"
                     /transl_table=11
                     /translation="MASSTPSPAITRDSPRWYEEYHAEAVSPWVFPPPGEDSVREPLWT
                     TSSHGVEFSAVPGGDAVWIVARFPSGAGTALRVAYCPRGRLAVVEARRTPSGVRLRIDA
                     ALGAFRTDVDLAGDDHPLLHVTTTLRPSVPTTVPYWPRDLVVLGEGSAGRVYARQEGLR
                     TGCVHFSITRPDTGTVFYFQNLTALNDYAQQTGTSLADVVGGTWPELGLALPASAGGAL
                     RPGHDTVISDAYLAFSPLVPEDDVAMAEQFLTATAEIVVALPRRSPAYVHWPDLAERSL
                     RDLSESPLCSMELRGNRFLNAYVGDAETPPESMVQLAVLLPLLEYAEWRREDIPLAGDL
                     LAGLGRFFDAEAGVMGRWLMSEKDRLDASEPHKKPGTMDSWYLYHSLLNLARLARRGDE
                     PARTLFLDSLDRAVEIAHRFAYRWPVLFNLHTLDVEVALSGDGESGESDVAALYAHVML
                     EAFELTGDRRYVTEAAAAADMLEGLGMSMFYQANVTLFGAAALLRLAQITGEDRFRRLT
                     HVAMASAVNNAWLWECDYGHARHYPTFFALFPLRGAPYIAILEAIESFSAAQHYLRLYA
                     GDMPKWMTVLLPEFCRGLLTRAGSYYPPNLPEAVVSDRPRVGAIDPQLWVPLEDLHDGW
                     EQAGQVGQEVYGAGAAFALVPRQYHRIVHAGLLVFTDYPVADFAHTGEREARLRVIGDP
                     RFPCRLRLIPAGPAPLPEVTVSVAGSPGTLPGTVTPEGHLDFELRGDQTAVIHWRPNEG
                     QHT"
     gene            complement(7711..8154)
                     /locus_tag="IEY99_RS10820"
                     /old_locus_tag="GCM10010166_21630"
     CDS             complement(7711..8154)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015620024.1"
                     /locus_tag="IEY99_RS10820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21630"
                     /product="HNH endonuclease"
                     /protein_id="WP_189201906.1"
                     /transl_table=11
                     /translation="MSVVLVLNADYGPLHRVSVRHAIRMLFREVAVVQEARPDERIGVF
                     PIPTVVRLVSYVVTRWRHSRGPSWSRGGVLSRDGRRCGYCGAAASTIDHVLPRSRGGGN
                     TWENTVAACGRCNQRKGDRTPAEARMPLRRAPRAPGWAELAAH"
     gene            complement(8369..9019)
                     /locus_tag="IEY99_RS10825"
                     /old_locus_tag="GCM10010166_21640"
     CDS             complement(8369..9019)
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015620025.1"
                     /locus_tag="IEY99_RS10825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21640"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_189201908.1"
                     /transl_table=11
                     /translation="MTWEQYAAAWSALHGGFDPRTATPVVRGWIRLAYRGGGLLASLGV
                     GPAAVTLAGLLLCAGVPFVPPLAGALLVLLAGIADALDGAVAVVAGRATRLGFVYDSVA
                     DRLGELAWLAAFWVAGAPGWLVVTGLALSWLHEYVRARAAAGGMQGVGVVTVGERPSRV
                     SVAAAGLAVAGVAGLVQPGWDRPGATLAVTVWSVLSVIGFGQLLAAVRRALID"
     gene            complement(9022..9948)
                     /gene="metF"
                     /locus_tag="IEY99_RS10830"
                     /old_locus_tag="GCM10010166_21650"
     CDS             complement(9022..9948)
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020512172.1"
                     /locus_tag="IEY99_RS10830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21650"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_189201910.1"
                     /transl_table=11
                     /translation="MSLGLPSRLPASPAIGELIRRPTPTFSFEFMPPKTPEGEQLLWRT
                     IRELEPLRPDFVSITYGAGGSTRDTTVDVTERVASETTLLAMAHLTAVGHSVAELRHVI
                     GRLAGAGIRNVLAVRGDPPGDPTGEWVRHPEGVLYAEDLVRLLREAGDFSVGVAAFPYK
                     HPRSPDIESDTRNFIRKCRAGADFAITQMFFEADEYLRLRDRVAAAGCDTPIVPGVMPV
                     LRMATIARAAQLSGAPFPPALLKRFERIADDEAGVRRLGIDLCSEMCRRLLDEGVPGIH
                     FITMNRSPATREVWQHLTGAAAAPAAA"
     gene            10001..11083
                     /locus_tag="IEY99_RS10835"
                     /old_locus_tag="GCM10010166_21660"
     CDS             10001..11083
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020215763.1"
                     /locus_tag="IEY99_RS10835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21660"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_189201912.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.8e-48, bitscore:
                     159.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPAPTSPLDRAGLRPRVDKALAAFLAAQRTRLLSIDPALTDVA
                     DALEAFVLRGGKRLRPAFAYWGYRGAGGPDGDEVVAAVSALELVQASALIHDDLMDRSD
                     TRRGEPSVHRRFAARHAAAGWHGAADAFGENAAVLLGDLALVWSDELLHTSGVAGADLA
                     RARPAFDEMRTEVTVGQYLDVLTSVTGDTSLARAGKVARYKSAKYTVERPLLLGAALAG
                     APAALSAAYSAFGLPLGEAFQLRDDVLGVFGDPELTGKPAGDDLRESKRTYLIAAACEA
                     VPEAGRAEIERGLGDPALDEADVTRLREIITSSGALRRTEARIAALTEEALAALAAADL
                     DPEARSVLLELADAATRRAV"
     gene            complement(11087..11455)
                     /locus_tag="IEY99_RS10840"
                     /old_locus_tag="GCM10010166_21670"
     CDS             complement(11087..11455)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015620028.1"
                     /locus_tag="IEY99_RS10840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21670"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_189201914.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 1.2e-16,
                     bitscore: 56.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYTVAAVLGVAAAVLTDLFVLRTRLVRRLVFWATYPIIIAFQLL
                     SNGILTGRRIVVYDPAAIVGWRIAYAPVEDLLFGFAMVLLTLSVWVWLGRRGVQREPRA
                     GEGSALLRWLRERPGRRP"
     gene            complement(11452..11784)
                     /locus_tag="IEY99_RS10845"
                     /old_locus_tag="GCM10010166_21680"
     CDS             complement(11452..11784)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015620029.1"
                     /locus_tag="IEY99_RS10845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21680"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_189201916.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 3.9e-21,
                     bitscore: 70.9, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHLSYLAVLAGCLACALWLEPVLKVNVLRRGRRLLLTLLPVAVV
                     FVLWDLAAIAAGHWTFDPEQTTGIVLPGGLPLDEVLFFLVVPVCAVLGFEAVRAVLRRP
                     AGDGDG"
     gene            complement(11793..12152)
                     /locus_tag="IEY99_RS10850"
                     /old_locus_tag="GCM10010166_21690"
     CDS             complement(11793..12152)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020521279.1"
                     /locus_tag="IEY99_RS10850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21690"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_189201918.1"
                     /transl_table=11
                     /translation="MTDATVDPAAGPTEWINLPDVADRLGVSISKVHQMIRDGALLAVK
                     RDGVRVVPAELVANAIVLKHLPGILTLLRDAGYNDEEALRWLYEPDETLGGSGAVALGG
                     DRAREVKRRAQALGF"
     gene            12249..13049
                     /locus_tag="IEY99_RS10855"
                     /old_locus_tag="GCM10010166_21700"
     CDS             12249..13049
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY99_RS10855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010166_21700"
                     /product="hypothetical protein"
                     /protein_id="WP_189201920.1"
                     /transl_table=11
                     /translation="MTLWRRTRAEVAGAWRSLRYDLGRRDPEPAAAQPGQALAGHGARR
                     AAYQDVTATGFSTFGGAGVTGGLHTSYGVEHARGPRRLVAVTAFGVLAVAGATGSYVAV
                     VNGLGSLLGEAGTEPYPLAAAAPGERGGESNQGLGRGSGEGPATAPEGTGGTIRVLPNP
                     AAATPAPGAPAAAGGATAPRPRRTSVAGTAPADRPEPCDCLTPPVPTPTAAPSSHDPAP
                     APSPSATTEDPVTPAPSDSPSSTASAGAGDDDGRTERAGRTRDR"
     misc_feature    13054..13067
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.36"
                     /tool="antismash"
     misc_feature    13056..13069
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.66"
                     /tool="antismash"
     misc_feature    complement(13056..13069)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.92"
                     /tool="antismash"
     misc_feature    13056..13072
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            13203..15155
                     /gene="pknB"
                     /locus_tag="IEY99_RS10860"
                     /old_locus_tag="GCM10010166_21710"
     CDS             13203..15155
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018821219.1"
                     /locus_tag="IEY99_RS10860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21710"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_189201922.1"
                     /sec_met_domain="Pkinase (E-value: 1.9e-50, bitscore:
                     167.2, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 3.1e-08, bitscore: 29.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTTVADTLIGTTIDGRYRITGRVARGGMATVYTAVDDRLERTVA
                     LKIIHPSQATNVHFVDRFTDEAKTIARLTHPNVVAVYDQGRHQGLPYLVMEYVQGRTLR
                     DLLNQRRRLNPVEALAILEQMLAAIAAAHRAGLVHRDVKPENVLVAEAPSGGIANLVDS
                     VVKVADFGLARAVEASTTDDTGQLMATVAYVAPELVTDGHADARTDVYSAGIVLFEMLT
                     GRVPYDGDVPVEVAWQHVDNDVPAPSSLVKGLPNVLDDLVARATRRDPGARPTDAGALL
                     AEVQVVRDDLGAANVETALLRQVPARAPLADPTALVPAVTSVFPAATDRPTWARLPEQN
                     KGGRGQRRSAPLAEAPAGRFDDRRRIFIVAAVALMVLTILGSTWYVTLGRYTEAPQFVN
                     MTRTQVEQEARAKGFALVFGDGRYDENVPKDVVLAQDPPAAERIVNGGQITLTLSLGPE
                     RHPVPDVVGLEVAAARGEIENIKLSFQEGTGEYSDTVPQGVVISTNPKAGQTLKPGETV
                     TVVVSKGKAPITVPPVVGRTIDEARNVLQGLGLTVVEQYKDSTQPANTVIAQSPGPGAG
                     AERDDEIKLEVSKGPPLVKVPDLTNQPCAQAAQTLTNLGLTPKVGIIQTGSVRAQLPPA
                     NTEVAPKSEVVLSCL"
     misc_feature    complement(13204..13218)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.83"
                     /tool="antismash"
     gene            15152..16024
                     /locus_tag="IEY99_RS10865"
                     /old_locus_tag="GCM10010166_21720"
     CDS             15152..16024
                     /EC_number="3.1.21.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0008833 - deoxyribonuclease IV
                     (phage-T4-induced) activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015620033.1"
                     /locus_tag="IEY99_RS10865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21720"
                     /product="deoxyribonuclease IV"
                     /protein_id="WP_373293319.1"
                     /transl_table=11
                     /translation="MSSPIGSHTKTSGGLAKAALPYADAAGSEAVQVYVSNSRGWALPP
                     GDPKQDTLFRDGCGERGLSAYIHASLLVNLGSPTELTVSRSVETLEHALRRGAAIGATA
                     VVYHAGSSVDPAHDDKALHQLKEALLPLLDAAAAQGLPRLLVEPSAGGGRSLASKMADL
                     GPYLAAVEHHPWLGVCFDTCHAWAAGHDLATPGGMTRTLDELVATVGPERLMLIHANDS
                     KDDCGSTRDRHETIGAGRIGAAAFGELFAHPATAGVPVIVETPTREHEGHAADIALLKE
                     LRAQCGASS"
     gene            complement(16003..16392)
                     /locus_tag="IEY99_RS10870"
                     /old_locus_tag="GCM10010166_21730"
     CDS             complement(16003..16392)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018792584.1"
                     /locus_tag="IEY99_RS10870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21730"
                     /product="DUF3224 domain-containing protein"
                     /protein_id="WP_189201924.1"
                     /transl_table=11
                     /translation="MTRRATGTFSTVFEPLPIDDDALSRMRVTKTIEGDLTGTASAEML
                     SVGTPIDGSAGYVAIDRVTGTLHGRSGSFVLQHYGLMNRGAGTLVVEVVPDSGTDELTG
                     LSGTFRIDNDSEHHRYVFDYELAPH"
     gene            complement(16442..17467)
                     /locus_tag="IEY99_RS10875"
                     /old_locus_tag="GCM10010166_21740"
     CDS             complement(16442..17467)
                     /NRPS_PKS="Domain: Beta_elim_lyase (2-281). E-value:
                     2.7e-83. Score: 271.5. Matches aSDomain:
                     nrpspksdomains_IEY99_RS10875_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018730697.1"
                     /locus_tag="IEY99_RS10875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21740"
                     /product="low specificity L-threonine aldolase"
                     /protein_id="WP_189202220.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.7e-08, bitscore:
                     28.9, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.4e-05,
                     bitscore: 20.1, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADLRSDTVTRPTAAMRAAMATAEVGDDVFGDDPSVNALEAHVAA
                     LFGHEAALFTPSGTMANQLALQLLVPRGEELLAGADAHVVTYELGGAAALGGISTRTWP
                     SVGAALDVEEIAAMIRPAGYPSVPTRAVAVEQTHNLGGGGVTDLGTLQELRKATAAAGV
                     ALHCDGARIWHAHVADGVPLAAYGELFDTLAVCLSKGLGAPVGSLVVGSAELIARARPL
                     RKRMGGGMRQVGILAAAGRHALDHHVDRLADDHARARRLAQALEPLGVVDPAAVRTNLV
                     PLDLSRSPLDAPSLAAAAAERGVLIAAMLPRTARLVTHLDLDDDAVDRAIEVLTALLRG
                     H"
     aSDomain        complement(16625..17461)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY99_RS10875_Beta_elim_lyase.1"
                     /evalue="2.70E-83"
                     /label="IEY99_RS10875_Beta_elim_lyase.1"
                     /locus_tag="IEY99_RS10875"
                     /protein_end="281"
                     /protein_start="2"
                     /score="271.5"
                     /tool="antismash"
                     /translation="DLRSDTVTRPTAAMRAAMATAEVGDDVFGDDPSVNALEAHVAALF
                     GHEAALFTPSGTMANQLALQLLVPRGEELLAGADAHVVTYELGGAAALGGISTRTWPSV
                     GAALDVEEIAAMIRPAGYPSVPTRAVAVEQTHNLGGGGVTDLGTLQELRKATAAAGVAL
                     HCDGARIWHAHVADGVPLAAYGELFDTLAVCLSKGLGAPVGSLVVGSAELIARARPLRK
                     RMGGGMRQVGILAAAGRHALDHHVDRLADDHARARRLAQALEPLGVVDPAAVRTNLV"
     gene            complement(17499..18905)
                     /locus_tag="IEY99_RS10880"
                     /old_locus_tag="GCM10010166_21750"
     CDS             complement(17499..18905)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475760.1"
                     /locus_tag="IEY99_RS10880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21750"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_189201926.1"
                     /transl_table=11
                     /translation="MRREWHQLSHPGVGATALQTSRPSTDSAEDSALGLDRWRELPRVQ
                     MPPWPDLDEVAEVCKVLDNVPSIVAPYEVDQLRHKLAEVCEGRAFLLQGGDCAETFADN
                     TESHLLANARTLLQMAVVLTYGASMPVVKVARVAGQYTKPRSSPTDSLGLPAYRGDMIN
                     SLEADEDARVADPQRMIRAYANSAAAMNMLRAYLAGGLADLAGLHDWNKDFVRASPAGE
                     RYEAIAREIDRALDFIRACGMTEDEALRTVSLYCSHEALALEYDRALTRVSQGRAYGLS
                     GHFLWIGERTRQLDHAHIDFVSRLANPIGVKLGPGTSPETAIELCEKLNPENVPGRLTL
                     ISRMGNGKVRDALPPIVEKVTAAGAKVVWQCDPMHGNTHESSNGYKTRHFDRIVDEVLG
                     YFEVHRGLGTHPGGIHVELTGEDVTECLGGAQGIEDLDLPGRYETACDPRLNTQQSLEL
                     AFLVAEMLRG"
     gene            complement(18981..20474)
                     /locus_tag="IEY99_RS10885"
                     /old_locus_tag="GCM10010166_21760"
     CDS             complement(18981..20474)
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015620006.1"
                     /locus_tag="IEY99_RS10885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21760"
                     /product="glycosyl hydrolase family 18 protein"
                     /protein_id="WP_189201927.1"
                     /transl_table=11
                     /translation="MKKTLRRALWAGVVVAVASATMPAVQASAAAACAPAWSSSAVYTK
                     DMTASQSGHNYTAKWWTQNESPATHSGQWDVWTDNGACGGTPPTTPPTTPPTTPPTTPP
                     TTPPTTPPTTPPTTPPTQGPGAGKYLVGYFAQWGVYGRNYHVKNIVTSGSAAKLTHILY
                     AFGNTTGGQCTIGDSYADYDRAYTAAESVDGVADTWDTGALRGSFNQLRKLKKQYPHIK
                     VIWSFGGWTWSGGFTQAAANPAGFANSCYNLVKDSRWADVFDGIDIDWEYPNACGLSCD
                     ASGADAYDRVISALRTRFGNSFLITSAISADGSAGGKLDVADYASGIAKLNLVFPMTYD
                     YFGAFNPQGPTAPHSPLTSYPGIPQQGFWSDAAIQKLKSKGVPANKMLLGIGFYGRGWT
                     GVTQSGPGGTATGAAPGTYEAGIEDYKVLKNTCPATGTVGGTAYAKCGSNWWGYDTPAT
                     IGGKMTYAKNQGLGGAFFWEFSGDTGNGELITAIRNGLG"
     misc_feature    20487..20501
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.05"
                     /tool="antismash"
     misc_feature    20488..20502
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.37"
                     /tool="antismash"
     misc_feature    complement(20490..20506)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.51"
                     /tool="antismash"
     gene            20644..21114
                     /locus_tag="IEY99_RS10890"
                     /old_locus_tag="GCM10010166_21770"
     CDS             20644..21114
                     /EC_number="1.11.1.-"
                     /GO_function="GO:0004602 - glutathione peroxidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0043295 - glutathione binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015621358.1"
                     /locus_tag="IEY99_RS10890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_21770"
                     /product="glutathione peroxidase"
                     /protein_id="WP_189201929.1"
                     /transl_table=11
                     /translation="MTIFDVDIDALTGGSADLRQYRGNVVLVVNVASRCGYTPQYAGLE
                     KLWQTYRDRGLVILGVPSNQFAGQEPGTAEDIQQFCSVNYGVTFPLTRKVDVNGPDRHP
                     LYGELIGEGAAVQWNFEKFVVGPDGTLAARFDPATEPDDERLVATIEKLLPR"
     misc_feature    complement(21134..21147)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    complement(21575..21590)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.39"
                     /tool="antismash"
ORIGIN
        1 gcgtggccat ggtggtcacc agcccggctg cgaccggacc ggtggccggt gagctcgacc
       61 gtcacgcgac gaacgggcgc gtgacgagcg ccgcgagcca tgccagtccc ggcacgtccg
      121 acacgcaggc accgacgagc gccgccaccg ccaggaccag gatcacgagg aaggcgacca
      181 gcgtcgcgaa ggccgtcccc tgggcggcca gatagcggca gagcggcggc cggggctcga
      241 cctccacatc atcaccctcg aagtcgaaca gagtcatggc gcgaacggta cggccagaaa
      301 ctcacgaccg gcggaatccc cgctccttct cctcgacacc gtcacaactt cgccacagac
      361 ccatgccgac gggcagcgca gtgggcgccg gttgctgtcc gggtgacgat ccgagtggtg
      421 ctgcatcgtc atctcggtgt aggcgtcatc gggcgtcaca ctgagacttg gaggagagac
      481 catgcgctac gcgttgctga tgcactacca ggagatgtcc gagggagaac tcagcgagga
      541 actgctccgt gaggggcagg cggccttcga cgcgtacggc cgggcgctgc agcaggccgg
      601 tgtgctgatc tcggccgacg tgctgcagcc gagcgccgcg acgacaaccg tcacccgcag
      661 ggacggtgtc acgcaggtgc aggacgggcc cttcgccgag acgaaggaga accttgccgg
      721 agtgttcctg ctggacgtgc ccgaccttga cgcggccatc ggctgggccg agaagtgtcc
      781 cggtgcccaa tggggcacga tcgaggtacg cccgaccgcg accgccttgg tcgagggcgg
      841 gtggacgcgc tgacgtccgg cgacgacgga cgggtagccg gccccgaccc gggtgggacg
      901 gggccggcgc cccaggtggc gcaggtggcg ggcttggcgg cccgggacag ctacgggcgg
      961 ctgctcgccc ttctgtctgc ctcgacgagc gatctcgcgt ccgcggagga cgcgcttgcc
     1021 gacgctttcg aacgcgcgct gcgaacctgg cccgatcacg gcgtaccggg caatcctgac
     1081 gcctggctcc tggccgtggc ccgtaaccgg ctccgcgacc gttggaagtc ggccgagtcg
     1141 cggcggaccc tcccgctcga catcgagcag cacgcaccgg ttcacctcga cgacctgacc
     1201 atcgacgcga tccctgatcg gcgcctcgag ctgatgctcg tgtgcgcgca cccggcgatc
     1261 gagcgtgcgg tccacacccc gctgatgctc aataccgtcc tcggcttcac cgccgatcag
     1321 atcggccggg ccttctccgt gccgacgtcg acgatggcca cccgcctggt ccgggccaag
     1381 cgacggatca aggcggccgg catcccgttt cgtcttcccg accgcggcga gctgcccgcg
     1441 cggatggcgg cggtgctcga ggccgtctac ggtgcctacg tcatcgactg ggcgacgacc
     1501 gggccgcagg aacgccgact gccaggagag gcactgcacc tcgccgaggt gctcagcacg
     1561 ttggtgcccg atgatcccga ggtgcacggg ctcgccgcgc tcgttcagct ctcggccgcg
     1621 cgcgcccggg cgcgaatcga ccgtgagggc cggttcgtcc cgctcgccga ccaagacccg
     1681 tcccgctggg accaccgcct gatcacccgg gcgcacgaac acctgcgcac ggcgcacgcg
     1741 cgcgggcagc tgggccgctt ccagctggag gccgcgatcc aagcagtgca ctgcgcacgg
     1801 cgacagaccg gcacgaccga ctggcccacc ctgctgaccc tgcaccgcct cctgcacacg
     1861 gtcgcgccgt cgctcggaag cggcgtcgcg ttcgccgcgg tcaccgccga ggtcgacggt
     1921 cccgccgccg ggctcgccat gctcgacgcc ctgctggacg acgcgggcgc gcacgcccga
     1981 cgcttccagc cggccagagc agcccgggca catctgctcg accggctcgg ccgcagcgaa
     2041 gaagccgtaa ccgcatacga cagcgcgatc gacctgaccc acgacaccgc cgagcggcag
     2101 tacctgcagc atcgccggga cgacgccggc cgccgggtcg ggcagcgcgg gtctgccgct
     2161 ccgagatccg gccctgactc cggcgtcgtg tgacccgagg atgtcgtacc cggcgggcag
     2221 gatggcgggc atggtgatga cgtcggtaac cgaggtggag cacgcgatcc ggtccgggtg
     2281 gtcgccggaa acctgcgatc ccgtggacct ggcggactgg tcaccggcca atcccgcccg
     2341 cggacaatgc ggggtgaccg cgctgctgct gcacgagctg ctcggtggcc ggctgctgct
     2401 ggcgaccgtg ctgcacgcgg acggcacccg ccagggcgtg cactactgga accgcctcgg
     2461 ccgcatcgag ctggatctga cgcgcgagca gttcaccgcc ggagaggtgg tgcaagctcc
     2521 cgccgtggtg gacccaccct cgggaccgcc cgtgcggctg cgggcgcaat acctgctgct
     2581 acaccgtcgg gttcacgacg ctttgagcct caccccggcg tcgccgccgc agtagccatc
     2641 gacccggcgc gcggatcgct tcgcggtgac cgcggtggcg acctcgtcgt cgcttgccac
     2701 gccgccggcc gccggcaccg atgtggacgg cgcttaggcc ggaggtgccg ggccggagcc
     2761 tggtggcgac ggcggcggcc ggcaccgatg tggacgctgc ttcagccgga ggtgccgggc
     2821 cggagcctgg tggcgacggc ggccgcggcc aggcacgcca ccgccgcggc gatcaggctc
     2881 gggcgtccgc cgaggtggac cgcggcggac ccgagcgggt tggccagcgc gatcgggccg
     2941 aacatcgcgg tgttcgcggt cgccgagacg cggccgagca ggtgggcggg ggtgtgcgtc
     3001 tgcaccgcgg tgaccgccgc gacgagcgtc cagggcaggc cggccccggc gacgacggcg
     3061 cccgccacga tcgccggcca ccacggcagg cagcgggcga gcaggcccgc cgcgaagagg
     3121 gccgtgccgg cggcgccggc cgcgatggcg ccgtgccggg agacgacccg gccggccgtc
     3181 aggcccgcga cgatcgaacc tgcgccctgc gcactcatca ggaggccgag gaaggtgctg
     3241 ggcaggtgca tgtcctcggt gacgaccgcg tagccgggcg ccgtggagaa gccggacaga
     3301 gcgatcgaga cgccggcaag cggcacggtc acccgcagca ccggccgggc gcgcagcacg
     3361 gccagtccgg ctcggaatcc ccgttcgacg gccgcagggg tggcactgcc ggtgaggccc
     3421 agcagggggt agaggagcgc gacgatcatc ggcatcagcg cgctcagcgc cgccaccgcg
     3481 gagccgccct gccaggcgta cagacccgcc ccggccagcg gggagagcag tttcatgccc
     3541 tcgcgcgcgg ccgagcgcca gccgttgacg gtgccgaggt gctgtggggc gagggccgcg
     3601 gggagcagcg ccgactcgcc cgcgtccagc accacatagc tgattccgta cgtgaacgag
     3661 acgaggtaga tcagccacgc ctgctgagcc gagtggacgg cgaagagtga gagcaacgcc
     3721 gcggcgagca cgaggttcgt cgcgaccagc agcgggcggc gcgggatccg gtcggtgatc
     3781 gcgccgagcc agggaccggc gagggtcggc gcgtagacgc agagccccgc cagtccggcg
     3841 cggccgggcg agccggtcag gtcgaggatc cagacgcccg tgaccagcga catcgcgctg
     3901 ccgccgaagc cggacagcag ggagatcgtc acgagtagca cggcgttgcg gcgcacatcc
     3961 gcctccaggg agttgagtca agaagactca tatcctcagg atccgcgtcg ggcaccggca
     4021 agaaggtgag agagcgtcaa tgcttcgttg acaacgcctg ccgtaccttg cggaacgcga
     4081 gccggacgtg cccgggcagg gccttcgcgc cggccgccgc gaggtcccgg gcggcctgct
     4141 cggcgagggc gtagaggccg ccggccggcg cgtccacggc ggcggcgacc gtgtcgcgca
     4201 ccagcgcggc gcggacgaag cgaccggccc agcgccggtc cgccgcgatg gcccggtgca
     4261 ggtcgcagac ggcctcgcgg aggacgacga tggagtgcgc gtaccgcagg tcgcggtggt
     4321 gcagccgcga ccgggcggcc gccaccaggc gctgccggcg ctgctcggcg gcctgccggc
     4381 tgcccaggcc cagcgccgcg gcgacctcgg tccaggtggc cccggcctgc cgggcccggt
     4441 cgatcagctc cagctcgcgc tcctccaggc gcgctcgtgc cggtccgatc tccgcgagct
     4501 gctccagaac agacacctgt caacgatacg ttgacgtgct cagatctcct ggcggtgcgg
     4561 gcggatcttg acgtcgacga cgtcgcagcg gcggggctgg gtgagcacgt acaggacgca
     4621 ggcggcgatg tcctccgcgc gcagcatctt cagctgctcg atctgctcgc gctgctgctc
     4681 gggggagaac tcgtcggcct gcatgtcgct gccgaccgcg cccggctcga tgaggctgac
     4741 cttgatgccg agcgggttca cctccttgcg tagcgcctcg gcgaagccct ggatgccggc
     4801 cttcgtcgcc acgtagaccg agctgccctc ctcccggacg tccgcgctca tcgagccgag
     4861 gcagacgatg tgaccgcggc cgcaggtccg catgcgcgcg atggcctcgt ggcagacggc
     4921 caggtagccc aggaagttgg tgcgcaccac gtacgaccac tcgtcgtacg tgccgtcgac
     4981 gatcgagccg gcgcccaggg ccgcgttggt gaccacgacg tcgaggccgt ccagccggct
     5041 gtcgatctcg gcgaagatcc gctggatgtc cgcggactcg gtcaggtcgg cctgcaacgc
     5101 caccacctgc ccgccggccc gctcgatgtc gtgcaccgcg tcgtccagct cccgctggtg
     5161 ccggcccacg atcaccacct gggcgcccgc cgacgcgagc aggatcgcgg tggcccggcc
     5221 gatcccggtg ctgccgccgg tgacgagcac ggtcttgccc gccaccggtt ccggcccggc
     5281 ggcctggtca ctccggtgtt cctccgtgag cacgttgctg gtcatgtgtg ctgtccctcg
     5341 ttcggtcgcc agtggatgac cgcggtctgg tcaccgcgga gctcgaaatc gagatggccc
     5401 tcgggtgtca cggtgcccgg gagcgtcccg gggctgccgg cgacgctgac ggtgacctcc
     5461 ggcagcggcg ccgggccggc cgggatcagc cgcaggcggc acgggaaccg cgggtcgccg
     5521 atgacccgca gcctggcctc ccgctccccg gtgtgcgcga agtccgcgac ggggtagtcg
     5581 gtgaacacca gcagtcccgc gtgcacgatg cggtggtact gccggggcac cagggcgaag
     5641 gcggcgccgg ccccgtacac ctcctgcccg acctgcccgg cctgctccca gccgtcgtgc
     5701 aggtcctcga ggggaaccca cagctgggga tcgatcgccc cgacgcgcgg ccggtcgctg
     5761 acgacggctt ccggcaggtt cggcggatag tacgagccgg cccgcgtcag cagtccccgg
     5821 cagaactcgg gcagcaggac ggtcatccac ttcggcatgt cgccggcgta caaccgcagg
     5881 tagtgctggg ccgcgctgaa gctctcgatc gcctccagaa tcgcgatgta gggggctccg
     5941 cgcagcggga acagggcgaa gaacgtcggg tagtgccggg cgtggccgta gtcgcactcc
     6001 cacagccagg cgttgttgac ggcactcgcc atcgccacgt gcgtcaggcg ccggaacctg
     6061 tcctcgccgg tgatctgtgc caggcgcagc agcgcggccg cgccgaacag cgtcacgttg
     6121 gcctggtaga acatgctcat cccgaggccc tcgagcatgt cggcggcggc ggccgcctcg
     6181 gtcacgtagc ggcggtcgcc ggtgagctcg aacgcctcca gcatgacgtg cgcgtacagg
     6241 gcggcgacat cgctctcgcc ggactccccg tcgccggaca gggccacctc cacgtcgagc
     6301 gtgtgcaggt tgaacagcac cggccagcgg tacgcgaacc ggtgggcgat ctcgacggca
     6361 cggtccagcg agtccaggaa cagcgttctc gccggctcgt caccgcgccg ggccagccgc
     6421 gcgaggttca gcagcgagtg gtagaggtac caggaatcca tggttcccgg cttcttgtgc
     6481 ggctccgagg cgtccagccg gtccttctcg ctcatcagcc agcgccccat gacaccggcc
     6541 tccgcgtcga agaacctgcc gagcccggcc aggaggtcgc cggccagcgg gatgtcctcc
     6601 cggcgccact cggcgtactc cagcagcggc agcaggacgg cgagctgcac catgctctcc
     6661 ggcggtgtct ccgcgtcacc cacgtacgcg ttgaggaacc ggtttccccg cagctccatg
     6721 ctgcacaggg gtgactccga caggtcgcgc agcgaccgct cggcgaggtc gggccagtgc
     6781 acgtaggcgg ggctgcggcg cgggagcgcc accacgatct ccgccgtcgc cgtgaggaac
     6841 tgctcggcca tcgcgacgtc gtcctcgggt acgagcggcg agaaggcgag gtacgcgtcc
     6901 gagatcaccg tgtcgtggcc cggccggagc gcgccgccgg ccgaggcggg cagggccaga
     6961 cccagctcgg gccaggtccc gcccacgacg tcggccagcg aggtgccggt ctgctgggcg
     7021 tagtcgttca gcgccgtgag gttctggaag tagaacacgg tgcccgtgtc gggccgggtg
     7081 atgctgaagt gaacgcaacc cgtgcgtagc ccctcctgcc gggcgtagac ccgcccggcg
     7141 gagccctcgc ccagcacgac caggtctcgg ggccagtacg gcacggtcgt cgggaccgac
     7201 ggtctcaggg tcgtcgtgac gtgcagcagc gggtggtcgt cgccggcgag gtcgacgtcc
     7261 gtacggaagg cgccgagcgc cgcatcgatc cgcagccgca ctcccgacgg ggtccggcgg
     7321 gcctcgacga ccgcgagcct cccgcggggg cagtacgcca cccgcagcgc cgtgccggct
     7381 ccggagggga aacgggcgac gatccagacc gcgtcgccgc cgggcaccgc ggagaactcg
     7441 acaccatggg acgaggtggt ccacaacggc tcccggacgg agtcctcgcc gggtggcggg
     7501 aacacccacg gcgagacggc ctccgcgtgg tactcctcgt accagcgcgg tgagtcgcgg
     7561 gtaatcgccg ggctcggcgt ggacgacgcc atcggtgggc tcctcgggca ggtgacagcg
     7621 cggcataccc ggcgaaaacg gcaataaacg cacacaccgc tccgagggga cgcccggcgg
     7681 gcccccgtgc ggtcccgccg gccgtcgtcc tcagtgcgcg gccagttccg cccagcccgg
     7741 cgcccgcggc gcccggcgca gcggcatccg cgcctccgcc ggcgtgcggt cccccttgcg
     7801 ctggttgcag cgcccgcacg cggcgacggt gttctcccag gtgttgcccc caccgcggga
     7861 gcgcggcagg acatggtcga tcgtggaggc ggctgcgccg cagtagccgc agcgccgccc
     7921 gtcgcggctc agcacgccgc cgcgcgacca ggacgggccg cggctgtgcc gccagcgcgt
     7981 cacgacgtag ctcaccagcc ggacgacggt cgggatgggg aagacgccga tgcgctcgtc
     8041 cggccgggcc tcctgcacca ccgcgacctc gcggaacagc atgcggatgg cgtgccggac
     8101 gctgacccgg tgcaacggcc cgtagtcggc gttgagtacg aggaccacgc tcatggcggg
     8161 tcacctcccg tgtcctggca ggacatgaaa aagccgcccg gccccggaca gcacggggcg
     8221 agcggcgacg gttgtcgctc gtgcgtcaac cgcgtcggtc gtccctgctt ccgtgccggc
     8281 aggccgtcat gtcgtctcct cgctgcccgg tgtcccgggc acgtcgtcgc ctcacaaggt
     8341 agggacgccg accgcgccgg acaacggatt aatcgatcaa cgcacggcgg acggccgcca
     8401 gcagctgtcc gaaaccgatc accgagagga cactccagac ggttaccgcg agcgtcgcgc
     8461 cgggccggtc ccatcccggc tgcacgaggc ccgccacgcc ggccaccgcc agcccggcgg
     8521 ccgccaccga cacccgggaa gggcgctcgc cgacggtgac cacgcccacg ccctgcatgc
     8581 cgccggccgc ggcgcgggcc cggacgtact cgtgcagcca gctcagcgcc aggccggtca
     8641 cgacgagcca gcccggcgcg ccggccaccc agaacgccgc cagccaggcg agctccccga
     8701 ggcggtcggc caccgagtcg tagacgaagc cgagccgggt ggcccggccg gcgaccacgg
     8761 ccaccgcccc gtcgagggcg tcggcgatcc cggcgagcag caccagcagc gccccggcca
     8821 gcggcggcac gaacggcacg cccgcgcaga gcagcaggcc ggcgagggtc accgcggccg
     8881 ggccgacgcc cagcgacgcg agcaggccgc cgccgcgata cgccaggcgg atccagccgc
     8941 gcaccaccgg ggtggcggtg cgcgggtcga aaccgccgtg cagcgccgac caggcggcgg
     9001 cgtactgctc ccaggtcacc gtcaggcggc ggcgggcgcg gcggccgcgc cggtcaggtg
     9061 ttgccagacc tcgcgggtcg ccggggagcg gttcatggtg atgaagtgga tgccgggcac
     9121 gccctcgtcg agcagccggc ggcacatctc gctgcacagg tcgatgccga gccggcgcac
     9181 gccggcctcg tcgtcggcga tccgctcgaa gcgcttcagc agggccggcg ggaacggcgc
     9241 gccggagagc tgcgccgcgc gggcgatcgt cgccatccgc aggaccggca tcacacccgg
     9301 cacgatgggc gtgtcgcagc ccgcggcggc cacccggtcg cgcagccgca gatactcgtc
     9361 cgcctcgaag aacatctggg tgatcgcgaa gtcggcgccg gcccggcact tgcggatgaa
     9421 gttgcgggtg tcgctctcga tgtcgggcga acgcgggtgc ttgtagggga acgccgccac
     9481 gccgacgctg aagtcgccgg cctcgcgcag cagccgcacc aggtcctcgg cgtagagcac
     9541 gccctcgggg tggcgcaccc actctccggt cgggtcgccc ggcgggtcgc cccggaccgc
     9601 gagcacgttg cggatgcccg ccccggcgag gcgcccgatg acgtggcgca gctcggcgac
     9661 cgagtggccg accgcggtga ggtgcgccat ggccagcagg gtcgtctccg aggcgacccg
     9721 ctcggtgacg tcgacggtgg tgtcgcgggt gctgccgccg gcgccgtacg tgatcgagac
     9781 gaagtcgggg cgcagcggtt cgagctcgcg aatggtgcgc cagagcagtt gctcgccctc
     9841 gggggtcttc ggcggcatga actcgaacga gaaggtcggg gtcggacgac ggatcagctc
     9901 accgatcgcc ggagacgccg gtaggcggga aggaagtccg agagacacac cggggattct
     9961 accggtccgg cccgcgcggc cgaccggcta ggtttgcccc gtgagctccc ctgccccgac
    10021 ctctcccctc gaccgtgccg gcctgcgacc ccgggtggac aaggccctcg ccgcctttct
    10081 cgcggcgcag cgcacccggc tgctctccat cgacccggcg ctgacggacg tcgcggacgc
    10141 cctcgaggcg ttcgtgctgc ggggcggcaa gcggctgcgg cccgccttcg cgtactgggg
    10201 ctaccgcggc gccggcggcc ccgacggcga cgaggtcgtc gccgcggtgt ccgcgctcga
    10261 gctggtgcaa gcgagcgcgc tcatccacga cgacctcatg gaccgctcgg acacccggcg
    10321 cggcgagccg tcggtgcacc ggcggttcgc cgcccgccac gccgccgccg ggtggcacgg
    10381 cgcggcggac gccttcgggg agaacgccgc ggtgctgctc ggcgacctgg cgctggtgtg
    10441 gtcggacgag ctgctgcaca cctccggggt ggcgggtgcc gacctggccc gggcccggcc
    10501 ggccttcgac gagatgcgca ccgaggtcac cgtcgggcag tacctggacg tcctcacctc
    10561 ggtgaccggc gacacatccc tggcccgcgc gggcaaggtc gcccggtaca agtcggcgaa
    10621 gtacaccgtc gaacggccgc tgctgctcgg cgccgccctg gcgggcgcgc ccgcggcgct
    10681 gagcgcggcc tactccgcct tcgggctgcc gctgggcgag gccttccagc tccgcgacga
    10741 cgtcctgggc gtcttcggcg acccggagct caccggcaag cccgcgggcg acgacctgcg
    10801 cgagagcaag cggacctatc tgatagcggc ggcctgcgag gcggtgcccg aggccgggcg
    10861 ggcggagatc gagcgcggcc tgggcgaccc ggcgctggac gaggcggatg tcacccggct
    10921 gcgcgagatc atcacgagca gcggggcact gcgccggacc gaggcgcgca tcgccgcgct
    10981 caccgaggag gcgctggccg cgctggccgc cgccgacctc gacccggagg cgcggagcgt
    11041 gctgctggag ctggccgacg cagccacccg ccgcgcggta tagaggtcag ggccgccggc
    11101 ccgggcgctc ccgtagccac cgcagcagcg cgctgccctc ccccgcccgg ggctcgcgct
    11161 gcaccccgcg gcgtccgagc cagacccaga ccgagagggt gagcagcacc atcgcgaagc
    11221 cgaagagcag gtcctccacc ggcgcgtacg cgatccgcca cccgacgatc gccgccgggt
    11281 cgtagacgac gatgcgccgc ccggtgagga tcccgttgga gagcagctgg aaggcgatga
    11341 tgatcgggta cgtggcccag aacacgagcc gccgcaccag ccgcgtgcgc agcacgaaca
    11401 ggtcggtcag caccgccgcg gccacgccga gcacggccgc caccgtgtag ctcatccgtc
    11461 gccgtccccg gccggacggc gcagcaccgc ccggacggcc tcgaagccca gcaccgcgca
    11521 caccggcacg accaggaaga acagcacctc gtcgaggggc agcccgccgg ggaggacgat
    11581 gccggtcgtc tgctcgggat cgaacgtcca gtgcccggcg gcgatggcgg cgaggtccca
    11641 cagcacgaag acgacggcca ccggcagcag cgtcagcaac aggcgccggc cgcggcgcag
    11701 cacgttgacc ttgagcaccg gttcgagcca gagcgcgcag gccaggcagc cggcgagcac
    11761 ggccaggtac gacaggtgac gcatccgccg gctcagaagc ccagggcctg cgcgcgccgc
    11821 ttgacctcgc gggcccggtc gccgcccagc gccaccgcgc ccgagccgcc gagggtctcg
    11881 tccggctcgt acagccaccg gagcgcctct tcgtcgttgt acccagcgtc gcggagcaac
    11941 gtgaggatgc cggggaggtg cttgagcacg atggcgttcg ccaccagctc ggccggcacg
    12001 acacggacgc cgtcgcgctt gacggcgagc agggccccgt cgcggatcat ctggtgcacc
    12061 ttgctgatcg acacgccgag ccggtccgcc acgtcgggca ggttgatcca ctcggtcggc
    12121 ccggcggccg ggtccacggt tgcatcggtc accggaccag cgtgccatgc cgtccgcgca
    12181 ccgcggcacg cggaacccct gacgacgccg ggaacgtccc ggctcgagcg gatcggagag
    12241 gtgtcccgat gaccctgtgg cggagaaccc gcgccgaggt ggccggagcg tggcggtcgc
    12301 tgcgctacga cctgggccgg cgggacccgg agccggcggc cgcgcagccc gggcaggccc
    12361 tggccgggca cggcgcgcgg cgggccgcgt accaggatgt gacggccacg gggttcagca
    12421 ccttcggcgg cgccggtgtc accggcggcc tgcacacctc gtacggcgtc gagcacgccc
    12481 gcggcccgcg ccggctggtc gcggtcacgg cgttcggcgt gctggcggtc gccggtgcca
    12541 cgggcagcta cgtcgcggtg gtcaacggcc tgggttcgct gctcggcgag gccggtacgg
    12601 agccgtaccc gctggcggcc gcggctcccg gcgagcgggg cggcgagtcg aaccagggcc
    12661 tgggccgggg ttccggcgag ggcccggcga ccgcgccgga ggggaccggc gggacgatcc
    12721 gggtgctgcc gaacccggcc gcggccaccc cggcgccggg cgcgcccgcg gccgccgggg
    12781 gagccaccgc tccccgcccg cggcggacct cggtggccgg gacggctccg gcggaccggc
    12841 cggaaccgtg tgactgcctg accccgccgg tgcccacccc gacggcggcg ccgtcctcgc
    12901 acgacccggc gccggcgccg tcgcccagcg ccaccactga ggatccggtc actccggcgc
    12961 cgagcgattc gcccagttcg accgcttccg cgggcgccgg tgacgacgac ggcaggacgg
    13021 aaagggcggg ccgcactcgc gaccgctgat ccgatttgtc atgataaaac gccccgcggt
    13081 gccgggcacc gcggggcgtt ttcaggctta tgcgccggtc cgcaggtcgt gccgtacccg
    13141 ttcggtctca gctcggtcat cctggtccgc cttttcctga agggcacata cacttcacgc
    13201 cgatggacac gactgtcgcc gacacgttga tcggcacgac gattgacggg cgctaccgga
    13261 tcaccgggcg cgtcgcccgc ggtggcatgg cgaccgtcta caccgccgtg gacgaccggc
    13321 tcgagcgtac ggtcgcactg aagatcattc acccgtcgca ggccaccaac gtccacttcg
    13381 tcgaccgctt caccgacgag gccaagacga tcgcccggct cacccacccg aacgtcgtcg
    13441 cggtctacga ccagggccgc caccagggcc tgccctacct cgtgatggag tacgtgcagg
    13501 gccgcaccct gcgcgacctg ctcaaccagc ggcgccggct caaccccgtc gaggccctgg
    13561 ccatcctcga gcagatgctc gccgcgatcg ccgccgcgca ccgcgccggc ctggtgcacc
    13621 gggacgtgaa gccggagaac gtgctggtcg ccgaggcgcc cagcggcggc atcgccaacc
    13681 tcgtggacag cgtggtcaag gtggccgact tcggcctggc ccgcgcggtc gaggcgagca
    13741 ccaccgacga caccggccag ctgatggcga cggtcgccta cgtcgcgccc gagctggtca
    13801 ccgacgggca cgccgacgcc cgcaccgacg tctactcggc cggcatcgtg ctgttcgaga
    13861 tgctcaccgg ccgcgtgccg tacgacggcg acgtcccggt cgaggtcgcg tggcagcacg
    13921 tcgacaacga cgtgcccgcc ccgtccagcc tggtgaaggg cctgccgaac gtgctggacg
    13981 acctggtcgc ccgggccacc cgccgcgacc ccggcgcccg gccgaccgat gccggcgcgc
    14041 tgctggccga ggtccaggtg gtgcgcgacg acctgggcgc cgccaacgtc gagaccgcgc
    14101 tcctgcgcca ggttcccgcc cgggcgccgc tcgcggaccc caccgcgctc gtgcccgccg
    14161 tcacctccgt cttcccggcc gccacggacc gccccacctg ggcccgcctg ccggagcaga
    14221 acaagggcgg ccgcggtcag cgccgctccg cgccgctcgc cgaggccccg gcgggccgct
    14281 tcgacgaccg ccgccgcatc ttcatcgtcg ccgccgtcgc cctgatggtg ctgacgatcc
    14341 tgggcagcac gtggtacgtc actctcgggc gctacaccga ggcaccgcag ttcgtgaaca
    14401 tgacccggac gcaggtcgag caggaggccc gcgccaaggg cttcgcgctc gtcttcggcg
    14461 acggccgcta cgacgagaac gtgcccaagg acgtggtcct ggcgcaggac ccgccggccg
    14521 ccgagcggat cgtcaacggc gggcagatca ccctcacgct ctccctgggt cccgaacgtc
    14581 acccggtgcc ggacgtggtc ggcctggagg tggccgccgc ccggggcgag atcgagaaca
    14641 tcaagctgag cttccaggag ggcacgggcg agtacagcga caccgtgccg cagggcgtgg
    14701 tcatctccac caaccccaag gcgggccaga cgctcaagcc tggcgagacg gtcaccgtgg
    14761 tggtcagcaa gggcaaagcc ccgatcaccg tgccgcccgt cgtcggaagg accatcgacg
    14821 aggcccgcaa cgtgctccag ggcctcggac tgacggtggt ggagcagtac aaggacagca
    14881 cccagccggc gaacacggtc atcgcccagt cccccgggcc gggcgccggc gcggagcggg
    14941 acgacgagat caagctggag gtcagcaagg gcccgccgct ggtcaaggtc cccgacctca
    15001 ccaaccagcc gtgcgcgcag gccgcgcaga cgctgaccaa cctgggcctg acgccgaagg
    15061 tgggcatcat ccagaccggt tccgtccgcg cgcagctccc gcccgccaac acggaggtcg
    15121 cgccgaagtc ggaggtcgtc ctcagttgcc tgtgagcagt ccgatcggat cgcacaccaa
    15181 gacgtcgggc ggactggcga aggcggcgct gccgtacgcc gacgcggccg gctccgaggc
    15241 cgtccaggtc tacgtctcca actcccgcgg ctgggcgttg ccgccaggcg acccgaagca
    15301 ggacacgctg ttccgggacg gctgcggcga gcgggggctg tcggcgtaca tccacgcctc
    15361 cctgctggtg aacctgggct cccccaccga gctgacggtc tcccggtcgg tggagacgct
    15421 ggagcacgcg ctgcgccgcg gcgcggcgat cggcgccacc gcggtcgtct accacgccgg
    15481 cagctcggtc gacccggccc acgacgacaa ggcgctgcac cagctcaagg aggccctgct
    15541 gccgctgctc gacgcggcgg ccgcgcaggg gctgccgagg ctgctcgtgg agccgagcgc
    15601 gggcggcggg cgcagcctcg cgtcgaagat ggccgacctc ggcccctacc tggcggcggt
    15661 ggagcaccac ccctggctcg gcgtctgctt cgacacctgc cacgcctggg cggcgggcca
    15721 cgacctggcg acccccggcg gcatgacgcg gaccctggac gagctggtgg cgacggtcgg
    15781 gccggagcgg ctgatgctga tccacgccaa cgactcgaag gacgactgcg gctcgacccg
    15841 cgaccgccac gagacgatcg gcgccggccg catcggcgcc gccgccttcg gcgagctgtt
    15901 cgcccacccc gccacggccg gcgtcccggt gatcgtggag acgccgaccc gggagcacga
    15961 gggccacgcc gccgacatcg ccctgctcaa ggagctgcgg gctcagtgcg gggcgagctc
    16021 gtagtcgaag acgtagcggt ggtgctcgga gtcgttgtcg atccggaacg tgccgctcag
    16081 gccggtgagc tcgtcggtgc cggagtccgg caccacctcg acgacgaggg tgcccgcgcc
    16141 gcggttcatc aggccgtagt gctgcaggac gaagctgccg ctgcggccgt gcagcgtgcc
    16201 ggtgacccgg tcgatggcga cgtagccggc cgagccgtcg atcggcgtgc cgaccgagag
    16261 catctccgcg ctggcggtgc cggtcaggtc cccctcgatg gtcttggtga cccgcatccg
    16321 gctgagcgcg tcgtcgtcga tgggcagcgg ctcgaagacg gtggagaagg tgccggtggc
    16381 gcggcgggtc atgggagctc ctcggcggtc gctgacggcg tgcgactccg atgtaaccag
    16441 atcagtggcc gcgcaggagg gcggtcagca cctcgatcgc ccggtcgacg gcgtcgtcgt
    16501 ccaggtcgag gtgggtgacc agccgggccg tgcgcggcag catcgccgcg atcagcacgc
    16561 cgcgctcggc cgccgccgcg gccagcgagg gggcgtccag cggcgagcgg ctcaggtcga
    16621 gcggcacgag gttggtgcgg acggcggccg ggtccacgac gccgagcggc tcgagggcct
    16681 gcgcgaggcg gcgggcccgg gcgtggtcgt cggcgagccg gtcgacgtgg tggtcgaggg
    16741 cgtgccgccc cgcggcggcg aggatgccca cctggcgcat gccgccgccc atccgcttgc
    16801 gcagcggccg ggcccgcgcg atgagctcgg cggagccgac gaccagcgat cccaccggcg
    16861 cacccaggcc cttcgacagg cagaccgcca gggtgtcgaa cagctcaccg tacgcggcga
    16921 ggggaacccc gtccgccacg tgcgcgtgcc agatgcgggc cccgtcgcag tgcagcgcca
    16981 ccccggccgc ggccgtcgcc ttgcgcagct cctgcagcgt gccgaggtcg gtgacgccgc
    17041 cgccgccgag gttgtgcgtc tgctcgaccg cgaccgcccg ggtcggcacc gacgggtagc
    17101 ccgccggccg gatcatggcg gcgatctcct cgacgtcgag cgccgcgccc accgacggcc
    17161 aggtgcgggt ggagatgccg cccagcgcgg cggcaccgcc cagctcgtac gtgaccacgt
    17221 gcgcgtcggc gccggccagc agctcctcgc cgcggggcac gagcagctgc agggcgagct
    17281 ggttggccat cgtgccggac ggggtgaaca gcgccgcctc gtgcccgaac agggcggcca
    17341 cgtgcgcttc cagcgcgttg acgctcgggt cgtcgccgaa gacgtcgtcg ccgacctcgg
    17401 ccgtcgccat ggccgcacgc atggccgcgg tcggccgggt gacggtgtcc gaccgcaggt
    17461 cggccacctc cggaccggtg gacgcgcccg agggcaggtc aaccacgaag catctccgcc
    17521 accaggaacg ccagttcgag gctctgctgc gtgttgaggc gcgggtcgca ggcggtctcg
    17581 tagcggcccg gcaggtcgag gtcctcgatg ccctgcgccc cgcccaggca ctcggtcacg
    17641 tcctcgccgg tcagctcgac gtggatgccg ccggggtggg tgcccaggcc gcggtgcacc
    17701 tcgaagtagc ccaggacctc gtcgacgatc cggtcgaagt ggcgggtctt gtagccgttg
    17761 gaggactcgt gggtgttgcc gtgcatcggg tcgcactgcc acacgacctt ggcgcccgcg
    17821 gcggtcacct tctccacgat cggcggcagc gcgtcgcgga ccttgccgtt gcccatccgg
    17881 ctgatcaggg tgagccggcc ggggacgttc tccgggttga gcttctcgca cagctcgatg
    17941 gcggtctcgg gggacgtgcc gggcccgagc ttgacgccga tcgggttggc gaggcggctg
    18001 acgaagtcga tgtgcgcgtg gtcgagctga cgggtgcgct cgccgatcca caggaagtgg
    18061 ccggagagcc cgtacgcccg gccctgcgag acgcgggtga gcgcgcggtc gtactccagc
    18121 gccagcgcct cgtgcgagca gtacaggctg acggtgcgca gcgcctcgtc ctcggtcatg
    18181 ccgcaggcgc ggatgaagtc gagcgcgcgg tcgatctcgc gggcgatggc ctcgtagcgc
    18241 tcgcccgcgg gcgacgcgcg gacgaagtcc ttgttccagt cgtgcaggcc ggccaggtcg
    18301 gcgaggccgc ccgccaggta cgcgcgcagc atgttcatcg ccgcggcgct gttcgcgtac
    18361 gcccggatca tgcgctgcgg gtcggccacc cgggcgtcct cgtccgcctc cagcgagttg
    18421 atcatgtcgc cgcggtacgc cggcagcccc agcgagtcgg tcggcgagga gcggggcttg
    18481 gtgtactgcc cggcgacccg ggcgaccttg accaccggca tcgaggcgcc gtacgtcagc
    18541 accaccgcca tctgcagcag cgtgcgggcg ttggcgagca gatggctctc ggtgttgtcg
    18601 gcgaaggtct cggcgcagtc gccgccctgc agcagaaacg cgcggccctc gcagacctcc
    18661 gcgagcttgt gccgcagctg gtccacctcg tacggcgcga cgatcgacgg cacgttgtcg
    18721 aggaccttgc agacctccgc cacctcgtcg aggtccggcc acggcggcat ctgcacccgc
    18781 ggcagctcgc gccaccggtc caggccgagc gccgagtcct cggcggagtc ggtggacggg
    18841 cgggaggtct gcagggccgt cgcgccgacc ccgggatgac tgagctgatg ccactctcgg
    18901 cgcataccag cagcctaacg agaggcacga gcgcggcgcc gggaggatcc ccccggcgcc
    18961 gcgccccgtg tgccggcggc tcagccgaga ccgttcctga tcgcggtgat cagctcaccg
    19021 ttgccggtgt cgccggagaa ttcccagaag aacgcgccgc cgaggccctg gttcttcgcg
    19081 tacgtcatct tgccgccgat ggtggccggg gtgtcgtagc cccaccagtt gctgccgcac
    19141 ttggcgtagg cggtgccgcc gacggtgccg gtggccgggc atgtgttctt gagcaccttg
    19201 tagtcctcga tgcccgcctc gtaggtgccc ggcgccgcgc cggtggccgt gccgcccggg
    19261 ccgctctgcg tgacgccggt ccagccgcgg ccgtagaagc cgatgccgag cagcatcttg
    19321 ttcgccggca cgcccttgct cttgagcttc tggatcgccg cgtcggacca gaatccctgc
    19381 tgcggaatgc ccgggtacga cgtcagcggc gagtgcgggg cggtggggcc ctgcgggttg
    19441 aaggcgccga agtagtcgta ggtcatcggg aagaccaggt tgagcttcgc gataccggag
    19501 gcgtagtcgg ccacgtccag cttgccgccg gcggagccgt cggccgagat ggccgaggtg
    19561 atcaggaagg agttgccgaa cctcgtccgc agcgcggaga tcacccggtc gtacgcgtcc
    19621 gcaccgctgg cgtcgcagga caggccgcag gcgttggggt actcccagtc gatgtcgatg
    19681 ccgtcgaaga cgtcggccca gcgcgagtcc ttcacgaggt tgtaacagga gttcgcgaag
    19741 ccggccgggt tcgcggcggc ctgggtgaag ccgccggacc acgtccaccc gccgaacgac
    19801 cagatcacct tgatgtgcgg gtactgcttc ttcagcttgc gcagctggtt gaacgagccg
    19861 cgcagggcgc cggtgtccca ggtgtcggcg acgccgtcga cgctctccgc cgcggtgtag
    19921 gcccggtcgt agtcggcgta cgagtcgccg atggtgcact gcccgccggt ggtgttgccg
    19981 aaggcgtaca ggatgtgggt gagcttggcc gcggagccgc tcgtcacgat gttcttcacg
    20041 tggtagttgc ggccgtagac gccccactgg gcgaagtagc cgacgaggta cttgcccgcg
    20101 cccgggccct gggtcggcgg agtcgtgggt ggcgtggtgg gcggggtcgt gggtggcgtg
    20161 gtcggcggcg tcgtgggcgg ggtcgtgggt ggcgtggtcg gcggcgtcgt gggcggggtg
    20221 ccgccgcagg cgccgttgtc ggtccagacg tcccactggc cgctgtgcgt ggccggtgac
    20281 tcgttctggg tccaccactt cgcggtgtag ttgtggccgg actgcgaagc ggtcatgtcc
    20341 ttggtgtaaa cggcggagga gctccacgcg ggagcgcagg ccgcggcggc ggacgcctgg
    20401 accgcgggca tcgtggcgga ggccaccgcc acgaccaccc cggcccacag cgcgcggcgg
    20461 agggtcttct tcactacgcc tcctcaaact tttaggaaac tttccaaatg gaagttgaag
    20521 agacggtagt cacatctatg aacatcagtc aagaaggtca cgcaggtttg acggaccgct
    20581 taacttttcg acagtgagcg ccacagcgtg cactcacaca ggcactacgc gtagtctgcc
    20641 gtcatgacca tcttcgacgt cgacatcgac gcactcaccg gcggatccgc cgatctgcgg
    20701 cagtaccgcg gcaatgtcgt cctcgtggtc aacgtcgcct cccggtgcgg ctacaccccg
    20761 cagtacgccg ggctggagaa gctgtggcag acgtaccggg accggggcct ggtgatcctg
    20821 ggcgtgccct cgaaccagtt cgccgggcag gaaccgggca cggccgagga catccagcag
    20881 ttctgctcgg tcaactacgg cgtcaccttc cccctcaccc gcaaggtcga cgtcaacggg
    20941 cccgaccggc acccgctcta cggcgagctg atcggcgagg gggcggccgt ccagtggaac
    21001 ttcgagaagt tcgtcgtcgg gcccgacggc acgctcgcgg cccgcttcga cccggccacc
    21061 gagccggacg acgagcgact cgtggccacc atcgagaagc tcttgccgcg ctgagccgcc
    21121 gatgagcctc cacgtgatcg gcgtcgacgc gtacgccctg ggctgggtcg gcgtcgagct
    21181 gcgcgacgga cacttcggcc gggcgatgct ggcgtccacc ctctacgaga tcgtcgccgg
    21241 cagctccggc gccgccgtca tcggcgtcga catcccgctc ggcatgctgc ccgaccgctg
    21301 gcgcgccgcc gacaccgtcg ccgccgacca cctgggcccc cggcgcagca gcgtcttccg
    21361 cgtcccgccg cgcgcggtct ggcaggagac cgacttcgcg gccgccaacc ggctctgccg
    21421 ggagctcacc ggcgccgggc tcagccgcca gtcctgggcg atgcggccca agctgctcga
    21481 ggcgaacgcg atctgggaac gccaccccgg cctgctcttc gaggcgcacc ccgaggtgtc
    21541 gttccgggag atggcgggcg agccgctcgc gtacgcgaag aagacctgga ccggccaggc
    21601 ccgccgccgc gacctgctcg cccggcacgg gatcgtcctg cccgaccagc tcggcccggc
    21661 cggtcaggcg cccccggacg acatcctcga cgccgccgcg gtggcctgga gcgcccaccg
    21721 gatggcgacc ggaaaggccc tgagccatcc cagcccgccc gaggaagcca acggcgcccg
    21781 catc
//
