LOCUS       NZ_BMQY01000001        25185 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Couchioplanes caeruleus subsp. azureus strain JCM 3246 sequence01,
            whole genome shotgun sequence.
ACCESSION   NZ_BMQY01000001
VERSION     NZ_BMQY01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Couchioplanes caeruleus subsp. azureus
  ORGANISM  Couchioplanes caeruleus subsp. azureus
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Couchioplanes.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1591226)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 64X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014648355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:32:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,801
            CDSs (total)                      :: 6,731
            Genes (coding)                    :: 6,630
            CDSs (with protein)               :: 6,630
            Genes (RNA)                       :: 70
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 101
            CDSs (without protein)            :: 101
            Pseudo Genes (ambiguous residues) :: 0 of 101
            Pseudo Genes (frameshifted)       :: 20 of 101
            Pseudo Genes (incomplete)         :: 93 of 101
            Pseudo Genes (internal stop)      :: 0 of 101
            Pseudo Genes (multiple problems)  :: 12 of 101
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:23:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 939911
            Orig. end                         :: 965096
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMQY01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25185
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25185
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25185
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15185](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15185)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            211..882
                     /locus_tag="IEY99_RS04405"
                     /old_locus_tag="GCM10010166_08880"
     CDS             211..882
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013936.5"
                     /locus_tag="IEY99_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08880"
                     /product="hemerythrin domain-containing protein"
                     /protein_id="WP_189199477.1"
                     /transl_table=11
                     /translation="MAVTQRGERPDTNEMVIVHQVYRREFRLLPALVRGVADGDRARAR
                     EVAEHCRFLTRALHHHHSDEDALLWPWLVAAAEVSTAVTERMQSQHERAAALLTEVDQL
                     TPCWAADADAVLREELAQTLTALHTVLVEHLDDEEANLLPLVAEYITVAQWRELSRRGR
                     RSMPMRQGLVFLGMMLQDATAAERSGILAQMPAPVRFIFSRIGMPAYRRYVTRIHPPTG
                     Q"
     gene            963..1241
                     /locus_tag="IEY99_RS04410"
                     /old_locus_tag="GCM10010166_08890"
     CDS             963..1241
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY99_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010166_08890"
                     /product="hypothetical protein"
                     /protein_id="WP_189199479.1"
                     /transl_table=11
                     /translation="MESDGAVLSHGYDRFGCALHTTRDRDAEVIRTALREVHPRDFHAD
                     RHPPGFVVEDLDSDGGLTAPLRVRYCGYEPSAHRIVRYAQTLTPSVT"
     misc_feature    1062..1064
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1361..1774)
                     /locus_tag="IEY99_RS04415"
                     /old_locus_tag="GCM10010166_08900"
     CDS             complement(1361..1774)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="IEY99_RS04415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08900"
                     /product="response regulator"
                     /protein_id="WP_189199481.1"
                     /transl_table=11
                     /translation="MATILVVEDTDDVRMALHRLFSRAGFTVMEAEDGRAALERAHRQP
                     PDVILTDLNMPHLDGLQLCQAIREDEGLSDIPVAILTGGVQPGDPRFAHSHVCGVWLKP
                     FNNAELVAAVQRLVQGGRHRHFDDPSSCPYRAA"
     gene            complement(1963..3618)
                     /locus_tag="IEY99_RS04420"
                     /old_locus_tag="GCM10010166_08910"
     CDS             complement(1963..3618)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024583.5"
                     /locus_tag="IEY99_RS04420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08910"
                     /product="ATP-binding protein"
                     /protein_id="WP_189199484.1"
                     /transl_table=11
                     /translation="MDLPDVAPVICDHRVLHEPEAVLAAALEAYVAIDAADRVVGWNTA
                     AEALFGYPHAEACGRDVAELIIPERYRQQHRAGLARVTAGGPGRVLGQRLQLAAIHRDG
                     HEFPIELTLTATDTPTGPVFHAFAHDITAAVRAGRFAAVEGAVSHGLAEASSSRAAATR
                     VVEALGVKMGWPVAELWLADPDRQLLCCAARHTEPGRRLGGFAMKELDYGIGLPGRVYA
                     ERQPRWIPDLATDATSVRSRAAAAIGLHVAVGVPIMAGGLTLGALCVYGDRVEDPEDTL
                     TGLLSGLAAHVGQYLERRRAEELAIELARTKDEFLALVTHELRNPLAVITSTAEMVNEE
                     AGTLAQDELRRYLDTISRNAQRLTVMAEDLLDLARLESGHLAIDTTATDLTDIIDASVE
                     GLAELSADKQLTVTVNTPARLPLHADPHRLRQVADNLLSNAIKYTPTGGTITITAHTHT
                     HNEPAGDTTTGGGEWIIWSFTDTGIGIPAIDRPRLFRRFYRASTALDRRIPGTGLGLVI
                     ARTILERHGGTITLADRPGPGTTFTIELPTKPPQ"
     gene            3854..4453
                     /locus_tag="IEY99_RS04425"
                     /old_locus_tag="GCM10010166_08920"
     CDS             3854..4453
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008598614.1"
                     /locus_tag="IEY99_RS04425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08920"
                     /product="recombinase family protein"
                     /protein_id="WP_189199486.1"
                     /transl_table=11
                     /translation="MTAVLIGYARCSTDKQDLEANRQILLDLGVPADQIYLDRAYSGTT
                     RARPGLDQALAAVRAGDTLVVPKLDRLARSVPDARQIGDSLAERRIRLQLGTMIYDPGD
                     PMGKMFFNILATFAEFEVDLLRMRTREGMAIAKAKGKLKGRAPKLSKTRQAHLIKLHAA
                     GEHSIAELAELFEVSRPTVYRVLERASITTATAGAA"
     gene            4516..5322
                     /locus_tag="IEY99_RS04430"
                     /old_locus_tag="GCM10010166_08930"
     CDS             4516..5322
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013736.5"
                     /locus_tag="IEY99_RS04430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08930"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_189199488.1"
                     /transl_table=11
                     /translation="MSITADRTALTDPARLAAVRRYEILDAPTDGQFDTIAAAAAAVCG
                     TPIATVSIVDADRVWFAATKGLDGVAQVGTEPGLCASAFCTEGPYVVNDAVTDPRTLDH
                     PLVRGELGLRFYAAAPIVTADGHHLGTVTAIDAMPRELTETQTTVLGHLADQVAQHLEL
                     RLATIKAVRAERQLRDEAEQRAAAAAELAAQMRAAAAVQATTPHPEHCQLGGTVGCTAP
                     AEIKIADSWGDSAWGCTTHVEEAILNVRSVFIASEELGGLAAYLNR"
     gene            complement(<5441..>5563)
                     /locus_tag="IEY99_RS04435"
                     /pseudo=""
     CDS             complement(<5441..5563)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011600011.1"
                     /locus_tag="IEY99_RS04435"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPGIGVRTAARILLEAGDGTAFKTPAHLAAGTSVSGSSDLG"
     misc_feature    5576..5589
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.66"
                     /tool="antismash"
     gene            complement(5932..7902)
                     /locus_tag="IEY99_RS04440"
                     /old_locus_tag="GCM10010166_08940"
     CDS             complement(5932..7902)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037016.5"
                     /locus_tag="IEY99_RS04440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08940"
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_189199490.1"
                     /transl_table=11
                     /translation="MFARRRVLGAGTALALVAVPLALTSQGAQAAPGASHTYTLNADFD
                     EGVANNVVHSTPDQLQLDDTVTAFPFIWVALSARGTIAKIDTVTGAVKGEYATTSDGDN
                     LHNPSRTSVANDGSVWAGNRNQSSVIHVGLVETGQCEDRNGNGTIETSTGYGNVLAWPG
                     GSNGNSSAASAALDECIRHYVDTQGSDARHLSVDAAGDVWVGSTSRAFQKVDGVDGTIV
                     AGSARTMPCGGYGGLIDGNGVLWSAVGASTLLRWDPNAVDSATNPRCLNVPAYGLAFDS
                     QNNVWASTLNSSQLVYKVSPDGATVQSFSMHHPNAQGLAVDGNDHVWISSSLIGGANRI
                     AHLKNDGSFVGEVTGAGDGSTGVSVDAAGKIWTANINSSDATRIDPNAGDLGTDGVTRI
                     GAFDLTVALPGAGPYNYSDMTGSALTGKPKSGTWSVVYDSGIPGAQWGTVDWTADTPSD
                     SKLTFTVASSSDGVTFGPTQSTTDGADLSVADGRYLRITATFTRATTEPAQSPILYDVT
                     VATADLNDAPVCTGATPSDAVLWPPNHKMVPITIKGLTDPDGDTLTTKITGIRQDEVVN
                     GPGDGATAPDGAGVGTDTAKVRAERAGTPKAPGDGRVYHVSFSVADGQGGTCTGTVKVS
                     VPHDQRGAAAVDGGPLYDSTV"
     misc_feature    8071..8082
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.92"
                     /tool="antismash"
     misc_feature    complement(8369..8387)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 25.71"
                     /tool="antismash"
     gene            complement(8853..10004)
                     /locus_tag="IEY99_RS04445"
                     /old_locus_tag="GCM10010166_08950"
     CDS             complement(8853..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019031080.1"
                     /locus_tag="IEY99_RS04445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08950"
                     /product="hypothetical protein"
                     /protein_id="WP_189199492.1"
                     /transl_table=11
                     /translation="MNDAIQAATRRFPLLGRPRPACPALPQRIQEVTDAVTAAEQKGEQ
                     GFADAAHALNKAALIASDCGLPYLAEQLCWQHIHVYRHLGRPLTIVEARYLLEPVLNLA
                     RLHIRADQGNAAIQLLEAMYDAVTRRQNLTVGDYLLPTAELTGDPLERRQLREWVWLQL
                     IGEGVRALALAGRWTAAAEHARAHKGIGIHLMEGRQAAIIAAILNDDLPQARNLLGESA
                     LTQPWELEVLSCFNLMCARPGVLSSERQLDVALAGYRARGPVSGYASYRARLGLTLVTL
                     AYPTRPDTAAILLREVAEETIAAADGYAARDLLSFRGPVDGITPAQRTRLTNINAESRL
                     GLRTLPDLALQQLTSSTLAAETALRTALVTCRNAVTGPSAGHH"
     misc_feature    complement(9741..9743)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..10933)
                     /locus_tag="IEY99_RS04450"
                     /old_locus_tag="GCM10010166_08960"
     CDS             complement(10001..10933)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289219.1"
                     /locus_tag="IEY99_RS04450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08960"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_189199494.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.3e-32, bitscore:
                     107.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTDHLTRTADELADHVEALLGGAAADDSLEVADAVETYRNAGRA
                     ALQKGQERATFQAHVRPLDWVKVEPAFATLVMPHLDRLEGYGWWFLRKHPDWRLRVRTR
                     HHDAVRGLLDRLVREGVIAGWQQSIYEPETGAFGGHYSINIVHDLFCADSRGVLDYVRQ
                     DTPAMGRRELSLLLVRALQQHAGLDPFEAGDVFDRVTRMRPPIDDVDRVGALATRMQQI
                     LSMPVREDNPLFAADGPLSYAAPWLAAHIDAGRRLRRGAVDGLLERGLRAILAQVVIFH
                     WNRLGLSATAQSVLAHAAKSALLPGESVR"
     gene            complement(10915..12075)
                     /locus_tag="IEY99_RS04455"
                     /old_locus_tag="GCM10010166_08970"
     CDS             complement(10915..12075)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788560.1"
                     /locus_tag="IEY99_RS04455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08970"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_189199496.1"
                     /sec_met_domain="LANC_like (E-value: 9.7e-38, bitscore:
                     126.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTASPAVVTSDEVDAQSLSSGAVGAALLAVEQALDGSGDWATVRQ
                     LIKAATAGPVDAAPHVGLYYGAPAIAFTLHATTADGHDRYLGARTALDQHLRRLIRDRL
                     RTANERLDSGQPATFAEYDLFYGLTGLATLLVRLAPGSDELGDLLHYVVRLTQPRREDD
                     LVVPGWWVDHDPDPLLPTPGGHANAGMAHGAAGLLALLAHAHLNGHQVTGQADAISRLC
                     AWFDEWQQDTAHGPWWPQWVTRECLCIGRPIQHGPGKPSWCYGAAGVARAQQLAALATA
                     DHTRRAAAEQALAACLLSPQLDRLSDAGLCHGVAGLYQTAYRAAADATTLAIAQELPAV
                     AERLTATASRDADGGFLTGRTGVALTLHTIRSGQPHTRWDACLLII"
     misc_feature    complement(10927..10929)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12072..15185)
                     /locus_tag="IEY99_RS04460"
                     /old_locus_tag="GCM10010166_08980"
     CDS             complement(12072..15185)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289221.1"
                     /locus_tag="IEY99_RS04460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_08980"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_189199498.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.8e-189,
                     bitscore: 625.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.9e-14,
                     bitscore: 49.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLNLRQYQPTGPILLRASTHPGDIAQDSDATGSSERSLAWLIEQ
                     WSRPELREAVTMASPTFAERVGQLVHAGDAASPNAVRRAVLALASYLARWQGRATPFAL
                     FAGINIATVGAATGRVGDQHTAVVRADADWLTRVVDRLERLHDLRRVLTVVADGAAIVR
                     DGRLVIAARPQAGERQPGPLREASTRFTHAVERALAHAARPVHFRELTVQLGTELSHAA
                     PHRIESLLHGLIDGGFLITNLRPPMTAEDGLAYVVDVLHAAGGPGLPEVAVVLGQLDGI
                     QARMLRHNAARTVREQAAIRAEAVEAMTALSPGSEYPLVVDLRLDAELSVPAGVVNEAA
                     QAAGVLLRLTTQPFGSAAWLDYHTRFRDRYGPGALVPVKELVADSGLGYPRGFLGAPRA
                     RPAWRVLTERDAYLLALIQQATLDGAQEITLTDADIDAMTIGDSSAAVPPARIELSLTV
                     NAPSVEALNKGTFALCITGAPRSYTSMAGRFAYLLDPTARGELARSYTDAANENTLTAH
                     LSFPPRRVHNQNVTRVGRLTTSVISLGEHPDGDDIGVDDLAVTADPDQLHLVQRSTGRR
                     VLAYMPHALDITVQTPPLARFIAEVGHARSAVFGPFDLGAAARTLPYTPRIRYQRTILA
                     AARWTLSATDLAPPPPTTGAQAHGPLTVGPSERWEKALYEWRERWRVPARVIACHGELR
                     LPLDLDRALDRALLHHRLTRAERLEIREDAPADAHRWVSHAAELLIPMTLKAPAPRPLP
                     VMDSPGQTLRPGASSLVRAHLIGNPARFDELLTKHLPALADSLIDGGLLRWWIRRHRDM
                     IRLDADQYLSIELRLREPAAFGPVAARLAAFADTLHQSGLPAEVLLAAHHAHPARYGLG
                     PAMEAAEQVFAADTTAAISQLRMSEQAGIPSHVLAAVSMVRLAAGFAPDPASGYMALLT
                     CLKGHTEPADRTLTELARTLADPTAGHQHLRDLPGGDVVTVAWHRRQDALQTYHARLRE
                     QRDPAVVLRTLLHEHHVRAVGVDPEFERKTNHLARAVAMRCLAPVSTR"
     misc_feature    complement(13065..13067)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(14448..14729)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IEY99_RS04460_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.60E-16"
                     /identifier="RREFam001.1"
                     /label="IEY99_RS04460"
                     /locus_tag="IEY99_RS04460"
                     /protein_end="246"
                     /protein_start="152"
                     /score="49.6"
                     /tool="antismash"
                     /translation="TVVADGAAIVRDGRLVIAARPQAGERQPGPLREASTRFTHAVERA
                     LAHAARPVHFRELTVQLGTELSHAAPHRIESLLHGLIDGGFLITNLRPP"
     misc_feature    complement(14637..14639)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(14730..14732)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15266..15457)
                     /locus_tag="IEY99_RS04465"
     CDS             complement(15266..15457)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289222.1"
                     /locus_tag="IEY99_RS04465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_189199500.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2e-16, bitscore:
                     56.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPQSAVLDGPADTVVTDDDDFELDMRVIESSTPLVIMMCSTSDG
                     CGSTCSTSACSTSSYDPA"
     CDS_motif       complement(15377..15457)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAPQSAVLDGPADTVVTDDDDFELDMR"
                     /locus_tag="IEY99_RS04465_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15266..15376)
                     /prepeptide="core"
                     /locus_tag="IEY99_RS04465_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-11.50"
                     /molecular_weight="3309.7"
                     /monoisotopic_mass="3307.5"
                     /core_sequence="VIESSTPLVIMMCSTSDGCGSTCSTSACSTSSYDPA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAPQSAVLDGPADTVVTDDDDFELDMR"
                     /leader_location="[15376:15457](-)"
                     /alternative_weights="3327.7"
                     /alternative_weights="3345.7"
                     /alternative_weights="3363.7"
                     /alternative_weights="3381.7"
                     /alternative_weights="3399.8"
                     /alternative_weights="3417.8"
                     /alternative_weights="3435.8"
                     /alternative_weights="3453.8"
                     /alternative_weights="3471.8"
                     /alternative_weights="3489.9"
                     /alternative_weights="3507.9"
     gene            complement(15525..17147)
                     /gene="fxlM"
                     /locus_tag="IEY99_RS04470"
                     /old_locus_tag="GCM10010166_09000"
     CDS             complement(15525..17147)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="IEY99_RS04470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09000"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_229798107.1"
                     /sec_met_domain="PCMT (E-value: 6.7e-36, bitscore: 120.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQISTVERPTQILSEPGISADPSLSAVMAQATAVAAAHTNEDGFC
                     GECLAAWGRLALHPCLSARWADALLARCSPEPLSTLQGSPTRRPAAIALMNSQNVVQDV
                     SVTKGIPVTEPATESHDDDHRTHTAASPRESLRTDPAGELRSALVERLRADGKITSAAV
                     EAAVRAVARERFLPADTPLEVAYGVDNSVVTKRDAHGVALSSVSAAYIQARMLEQAELQ
                     PGMSVLEVGSGGLNAAMIAEIVGPEGHVLSVDIDSEVTDRAARLLDEAGYGKRVRVIAA
                     DAAEGLPGEGPFDAIIVTVGAWDIAPAWLEQLKDGGVLVLPLIMNGVTRTIGFRFDGEA
                     LASTSTEVAGFVPMQGIGQHPERVFLLPDANGKQVKLRFDSGAPQDMSALDSVLATDRV
                     QVWSGVTIPHGVSFADLHLWFAWYLPGFCLLAVDEGTELAAEYGKWFPFGVVRGSAFAY
                     LAVRPALDGGGVEFGASAYGRDGELAAMAMVEQIKAWDRDGRHRDPSFTYWPSGTEKSL
                     RSADVAVMDKTHGVLTISWPARG"
     gene            complement(17181..17420)
                     /locus_tag="IEY99_RS04475"
                     /old_locus_tag="GCM10010166_09010"
     CDS             complement(17181..17420)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018221847.1"
                     /locus_tag="IEY99_RS04475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09010"
                     /product="hypothetical protein"
                     /protein_id="WP_189199502.1"
                     /transl_table=11
                     /translation="MPGDQQGPRRLRAGDMVHVSRAASVQFAIGFNFRVIRVDDKPTYE
                     GWCWLDGYQMDGDGMAIERRKIFVQVAGLRPARQ"
     gene            18064..19467
                     /locus_tag="IEY99_RS04480"
                     /old_locus_tag="GCM10010166_09020"
     CDS             18064..19467
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018807637.1"
                     /locus_tag="IEY99_RS04480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09020"
                     /product="hypothetical protein"
                     /protein_id="WP_189199504.1"
                     /transl_table=11
                     /translation="MTTLLKALLRERHWQKYVTFCKEWDRVATQLDPDLVGAYPSRSQL
                     ARWLAGDLKGLPHPDACRILEGLFPGLAAPQLFASGSTTTVLSLSGQPSILVTPPTSAP
                     APGRSDVPSEEVLAKKAHSTVDGTLGEEIAMAAEESARFVRRARGAVNQDVLDQLDDDV
                     QQMARDYLARPPYMMFRPLARLRTEVFELLEERQRPTVLPGLYRVAGQLCALLAHACAD
                     LGQAYAADTHTRTAWLCADLAENNPLRAYVRWVQSNVAYWNGDYRRAAEHAHSGQRYAT
                     MGTSLLRLASQEARAHAAAADHKAADAALGTAQAARAHLGPGDDEPGGVFRFAPGKAAY
                     YASEVRLALGGKENYRQAATDAQQALELFAAQPESDHCPEFFAAAQLDLVAAHLAQDDL
                     NGAEEHLLPVFALPTESRTLPVVKRVATTDHALASQRFANAALAVELRERIHLFCAYTA
                     TRELPALPH"
     misc_feature    18775..18777
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19492..19989
                     /locus_tag="IEY99_RS04485"
                     /old_locus_tag="GCM10010166_09030"
     CDS             19492..19989
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lysine_decarbox"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF037785.5"
                     /locus_tag="IEY99_RS04485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09030"
                     /product="LOG family protein"
                     /protein_id="WP_189199506.1"
                     /sec_met_domain="Lysine_decarbox (E-value: 1.1e-08,
                     bitscore: 31.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALQVAVCGPRYCTDEDAKRARRVGELLAEQGAVIVCGGGVGVMA
                     AVAEGARTKGGLVIGIRPNGSKEGASPDLSATIVTNMGEARNAIIVWSADAVISIGGSW
                     GTLSEVALAMRRGDVPVVALGGWRVVQADGETVPGIRYVDTPADAVAAAISAAQEAPKT
                     TA"
     gene            complement(20020..20682)
                     /locus_tag="IEY99_RS04490"
                     /old_locus_tag="GCM10010166_09040"
     CDS             complement(20020..20682)
                     /EC_number="3.4.23.43"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019033974.1"
                     /locus_tag="IEY99_RS04490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09040"
                     /product="prepilin peptidase"
                     /protein_id="WP_189199508.1"
                     /transl_table=11
                     /translation="MNALAASGIAVAGALAGVPIAAIAYSAPERGSVRVPERWWRGAPA
                     RPTTVAVVSALTGAAAGLVAVCLPLSLTLPAFWTFAVLGVGLAITDLRRHRLPYALTGT
                     LAAACTICFTLPVVMGGSSVPVLRALTAGSVTVVALLILALSLPGQLGLGDVALAGVVA
                     LSLGWLSWQAAAAGVLGAFLIQPAVVLVSKLRGAGRVTPMGPAFLVAWLGSVVAHGM"
     misc_feature    complement(20191..20193)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20686..21000)
                     /locus_tag="IEY99_RS04495"
                     /old_locus_tag="GCM10010166_09050"
     CDS             complement(20686..21000)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018817817.1"
                     /locus_tag="IEY99_RS04495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09050"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_189200626.1"
                     /transl_table=11
                     /translation="MHSSTNITRRKLNLAILTALRDGPLRYSRLHHAVSQTSLEVVHAR
                     TLTRTLTHLQEEGLVEHHQEADTADYRLTIAGTELVDLLAELERWTREHRTDDRDEDDR
                     "
     gene            <20984..21460
                     /locus_tag="IEY99_RS04500"
                     /old_locus_tag="GCM10010166_09060"
                     /pseudo=""
     CDS             <20984..21460
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018733376.1"
                     /locus_tag="IEY99_RS04500"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09060"
                     /product="site-specific DNA-methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LVEECIALMAGIRNGLLVPRASFFQIKNVGDAIAAGDPQWLTQHE
                     DVIILRLGQPQDSADTEPVGVNAHTDHWLDAFTPARVDRRAHPAHPGHANPGRSAPDTR
                     PYPGRDTERTADPCPPYPHPIAGAVRPDTTTHRRHTDPDGPCPPTGTPDTAGSR"
     misc_feature    21050..21063
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.28"
                     /tool="antismash"
     gene            21457..21666
                     /locus_tag="IEY99_RS04505"
                     /old_locus_tag="GCM10010166_09070"
     CDS             21457..21666
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018799437.1"
                     /locus_tag="IEY99_RS04505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09070"
                     /product="AlpA family transcriptional regulator"
                     /protein_id="WP_189199510.1"
                     /transl_table=11
                     /translation="MSASTVAEWRPDPLLTVDDVAAWLGKPKNTLYAWHSRGKGPRAIR
                     VGNTLRYRRSEVDRWLDSHTDPER"
     gene            21670..22851
                     /locus_tag="IEY99_RS04510"
                     /old_locus_tag="GCM10010166_09080"
     CDS             21670..22851
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018793227.1"
                     /locus_tag="IEY99_RS04510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09080"
                     /product="site-specific integrase"
                     /protein_id="WP_189199512.1"
                     /transl_table=11
                     /translation="MARPPLPVGTWGKIRTEQLGPNRHCARARFRDYDGTTRDVEAIGT
                     TGPAAIRALQVKLRDRVAPNDDEITRETHISTLADLWLDDIIAAGEVTPQTISRYEISV
                     RVSIVPALGKLRIREAGAGRLDKFLREVAKDRPAAARGAKVALRQMFALAVRRGALTTN
                     PVRETGRLRNPRRKVVVALDHEQLNGVRSAIREWQKPTPGKSGPRPTGDLADIVDLMLA
                     TGARIGEILALRWEDLDLADERPTLTICGTIVYVKGKGFYRQEWTKTDAGFRSTVLPRF
                     AVGMLMARKLTANANPNDAIFASRRGTWLSPQNFRRQWRRVRAETGLEWVTPHTFRKTV
                     ATLIDKEADTDSAAAQLGHGSKEVTKKHYIVKPALAPDNSAILEQLGDRRATG"
     misc_feature    22228..22230
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(23138..23620)
                     /locus_tag="IEY99_RS04515"
                     /old_locus_tag="GCM10010166_09090"
     CDS             complement(23138..23620)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015621138.1"
                     /locus_tag="IEY99_RS04515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09090"
                     /product="ATP-binding protein"
                     /protein_id="WP_189199514.1"
                     /transl_table=11
                     /translation="MLNLAPTLPPADAEVLHVWVLDERSQLPTLKASLLDVVIQQRPLA
                     QYAIGTVDKMMLVATELAANAITYGLPPTVVRLFADGPSLIVDIADHDTQIPPEFADAQ
                     PPGAGGLGLRLALKFALAVGWYATDTTKHIWAEFLNDDTEATSRATAAGSKPTTAA"
     misc_feature    complement(23435..23437)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            24147..24413
                     /locus_tag="IEY99_RS04520"
                     /old_locus_tag="GCM10010166_09100"
     CDS             24147..24413
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.5"
                     /locus_tag="IEY99_RS04520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010166_09100"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_189199516.1"
                     /transl_table=11
                     /translation="MIGDLEACVVASFRDQMAALLTAPVRVVDLDLAGVGFCDAAGARE
                     LLALRDRAAQQQITVVLVAAHRAVRLVLHLFGERAWDPEPHER"
     misc_feature    24700..24710
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    24760..24780
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.6"
                     /tool="antismash"
ORIGIN
        1 gctcaccgca tcgaggagtc aaccgcttga tctcaagccc cactccacgg gtgcacaccg
       61 gcagtatgcg agccagtgac ctgtcgtggt cggcgcggct ctactgccgg cttgccggtc
      121 cgcctcaatg actcatgccg ccgtggcgga ggcccgacgg gccgtccggg tgggaggctg
      181 tccgccggac caagaccgca ggtgaggaga gtggctgtga cgcagcgcgg cgaacgtccg
      241 gacaccaatg agatggtgat cgtgcatcag gtgtaccggc gcgagtttcg cctgctgccc
      301 gccctggtcc gcggcgtggc ggacggcgac cgcgcccgcg cccgtgaggt ggccgagcac
      361 tgccgtttcc tgaccagggc gctgcatcat caccacagcg acgaggacgc gctgctctgg
      421 ccctggctcg tcgccgctgc cgaggtcagc actgcggtga ccgagcgcat gcagagtcag
      481 catgagcggg ccgccgccct actgaccgag gtcgaccagt tgacaccgtg ctgggcggcc
      541 gacgccgacg cggtcctccg ggaggagctt gcgcagacgc tcaccgcatt gcacaccgtg
      601 ctcgtcgagc acctggacga cgaggaggcg aacctgctgc ccttggttgc cgagtacatc
      661 accgtggcgc agtggcggga gttgagccgc cggggtcgac gcagcatgcc gatgcgtcag
      721 ggcctcgtct tcctcggaat gatgctgcag gacgccaccg ccgccgagcg gtccggcatc
      781 ctggcccaga tgccggcacc cgtacggttc atcttttcgc gaatcgggat gccggcctac
      841 cggcgctacg tcacccggat ccacccgccc accggccagt gagccgcttc gctaccacac
      901 accctgtagc tgcccgctac cagagtgagg attatggagg catcgacggg acactagggg
      961 ctatggagag cgatggtgcc gtcctctcgc acggctacga ccgcttcggt tgtgcactgc
     1021 acacgacccg agaccgtgac gccgaagtca tccggaccgc gttacgcgag gtccacccgc
     1081 gcgacttcca cgccgaccgc catcccccgg gcttcgtcgt tgaggacctc gactcagacg
     1141 gcggcctcac cgcgccgttg cgggtgcgct actgcggcta cgaaccgtcc gcccaccgga
     1201 tcgtccgcta cgcgcagacc ttgacaccgt cggtcacctg acccgaagac gtgtcggcag
     1261 tcgcaaccac tacacatcca ccccgccggc cggttccgcc gtcgcgccga ggccgaccgg
     1321 tgccctgacc accgagtgac ccgccctcag cgggcgtccc tcacgcggcg cgatatgggc
     1381 aggacgaagg atcgtcgaag tggcggtggc ggccgccctg taccaggcgc tgcactgcag
     1441 cgacgagttc ggcattgttg aacggtttga gccacacacc acagacgtgg ctgtgcgcga
     1501 agcgcggatc tccgggttga acccctcctg taaggatcgc cacggggatg tcgctcaacc
     1561 cttcgtcttc gcgaatggcc tgacacagtt ggaggccgtc gagatgcggc atgttcagat
     1621 cggtcaggat gacatcgggt ggttgccggt gagcccgttc cagggcggcg cgtccgtctt
     1681 ccgcctccat caccgtgaat ccagcccggc tgaagagacg gtgcagagcc atgcggacat
     1741 cgtctgtgtc ctcgacgacg agaatggtgg ccatcagcag atcctttctc gggcgtttgc
     1801 cgctcgcgcg gccccacggt ggcggagtgc ttctgatcaa gttcattgtt ccgctgatgc
     1861 cgcgctcaga ccggtagacg gcatagatgg gaccgagcga atccacgcaa ggacctaagt
     1921 gccatggccg ccacagcagg ccatggcatt cggcggttgg ctctactgcg ggggcttggt
     1981 gggcagctcg atggtgaagg tggtgcccgg tcccggacga tcggccaggg tgatggtgcc
     2041 gccgtggcgt tcgaggatgg tgcgggcgat gaccaggccg agcccggtgc cggggatgcg
     2101 gcggtcgagc gcggtggagg cgcggtagaa gcggcggaac agtctggggc ggtcgatggc
     2161 cgggatgccg atgccggtgt cggtgaacga ccagatgatc cactcgccgc cgcctgtggt
     2221 ggtgtcgccg gccggttcgt tgtgggtgtg ggtgtgggcg gtgatggtga tggtgccgcc
     2281 tgtcggggtg tacttgatcg cgttggacag caggttgtcc gcgacctgtc gcagccggtg
     2341 agggtcggcg tgcagcggca accgcgcggg ggtgttcacg gtgacggtga gctgcttgtc
     2401 ggcagatagt tcggcgaggc cctcgaccga ggcgtcaatg atgtcggtga ggtcagtagc
     2461 ggtggtgtcg atggcgagat gcccggattc gaggcgggcg aggtcgagga ggtcttcggc
     2521 catcacggtg agccgttgcg cattgcggct gatggtgtcc aggtagcggc gcagctcgtc
     2581 ctgggcgagg gtaccggctt cctcgttgac catttccgcg gtgctggtga tcaccgcgag
     2641 gggattgcgc agctcgtggg tgaccagggc caggaactcg tccttggtgc gagctagctc
     2701 gatggcgagt tcctcggcgc ggcggcgttc caggtactgc ccgacgtggg cggcgagacc
     2761 ggacagcaag ccggtcagtg tgtcctcggg gtcttcgact ctatcgccgt agacgcacag
     2821 ggctcccagc gtgagcccac cggccatgat cggcactccg accgcgacgt gcagaccgat
     2881 cgccgcggcg gcgcggctgc gcaccgatgt cgcgtcggtg gctaggtccg ggatccaccg
     2941 cggctggcgt tcggcataga cgcggccggg cagcccgatg ccgtagtcca gctccttcat
     3001 ggcgaagcca cccaggcggc ggccgggctc ggtgtgccgg gcggcgcagc acagcagttg
     3061 ccggtcgggg tcggccagcc acagttcggc caccggccag cccatcttca cgccgagcgc
     3121 ctccaccacc cgggtggcgg cggcgcggct ggagctagct tcggccagcc cgtgcgagac
     3181 ggcgccctcc acggcggcga accggcctgc gcgcaccgcc gcggtgatgt catgggcgaa
     3241 ggcgtgaaac accggcccgg tcggggtgtc ggtggcggtc agagtcaact cgatcgggaa
     3301 ctcgtggccg tcacggtgga tcgccgccag ttgcagccgc tgtccgagta cccggccggg
     3361 gccgccggcg gtcacccgtg ccaggccggc gcggtgctgc tgccggtacc gttccgggat
     3421 gatcagctcg gcgacgtccc ggccgcacgc ctcggcgtgg gggtagccga acagggcctc
     3481 ggcggccgtg ttccagccga ccacccggtc ggcggcgtcg atggcgacgt atgcctccaa
     3541 cgccgcagcg agtacggcct cgggttcgtg cagcacacga tggtcacaga tgaccggtgc
     3601 cacgtcgggc aggtccatgg cactcccccc accgctgtgc tcaccgtcgg actgtgcggg
     3661 cgccggtcgg ggggaataag gaggaggcgc tgcaggggca gcgtaccgcc gccgtccgtt
     3721 gaaggaaccc ccaatggaca cccttcccct gctccccgcg ccacggtgac cagcgacgcg
     3781 acctgtctca catagggtgt ccggtgatct gtccggtgag cgggggctat ccgttaccga
     3841 taggctcacc ggcatgaccg ccgtgctgat cggctacgcc cgctgttcca ccgacaaaca
     3901 ggacctggaa gccaaccggc agatcctgct cgacctcggc gtgcccgctg atcagatcta
     3961 cctcgaccgg gcgtactccg gcaccacccg cgcccggccc ggcctcgacc aggccctggc
     4021 cgccgtccgc gccggcgaca ccctcgtggt gccgaaactc gaccggctcg cccgttccgt
     4081 cccggacgcc cggcagatcg gcgactccct cgccgagcgc cgcatccggc tgcagctcgg
     4141 caccatgatc tacgacccgg gcgacccgat gggcaagatg ttcttcaaca tcctggccac
     4201 cttcgccgag ttcgaggtcg acctgctgcg catgcgcacc cgcgaaggca tggccatcgc
     4261 caaggcgaag ggcaaactca agggccgggc cccgaaactg tcgaagaccc ggcaggcgca
     4321 cctgatcaaa ctgcacgccg ccggcgaaca cagcatcgcc gaactggcgg aactgttcga
     4381 ggtgtcgcgc ccgacggtgt accgagtcct cgaacgcgcc agcatcacga cagccacagc
     4441 gggtgcggca tgaccgccgc aaccgcgtac tccaccccgg cctgaacacc ccccatcaga
     4501 agcgagcacc acaccatgtc gatcaccgct gacaggaccg ccctcaccga ccccgcccgg
     4561 ctcgctgcgg tacgccgtta cgagatcctc gacgccccca ccgacggcca attcgacacc
     4621 atcgcggcgg ccgccgcagc ggtatgcggc accccgatcg ccacggtcag catcgtcgac
     4681 gccgaccggg tctggttcgc cgcgaccaag ggactggacg gcgtcgcgca ggtcggcacc
     4741 gaaccgggac tgtgcgcgtc ggcgttctgc accgagggcc cgtacgtggt caacgacgcg
     4801 gtcacggatc cgcgcaccct cgaccatccg ttggtacgtg gcgagctggg gctgcggttc
     4861 tacgccgccg ccccgatcgt caccgccgac gggcaccacc tcggcaccgt caccgcgatc
     4921 gacgccatgc cccgggaatt gaccgagacg cagacgaccg tgctcggcca tctcgccgac
     4981 caggtcgcgc agcacctgga gctgcgcctg gccaccatca aggcggtacg cgccgaacgt
     5041 cagctgcgcg acgaggccga gcaacgcgcc gccgccgccg ccgaactcgc cgcccagatg
     5101 cgcgccgcgg ctgcggtgca ggccaccacg ccgcaccctg agcactgcca gctcggcggc
     5161 accgtcggct gcaccgcacc agccgagatc aagatcgccg actcgtgggg cgactcggcc
     5221 tggggctgca ccacccacgt cgaagaggcc attcttaatg tccgttcggt gttcatcgcc
     5281 agcgaagaac tcggcggcct ggccgcctac ctcaaccgct gaccgtcacc gcgaaccaac
     5341 ctccccggcc ccgtgcggca ccggcagccg gtgaccgccc gccacgcgcg cacccgccgc
     5401 taccagcctc gtggagcact ggctgcttgg gcaatctcta accaagatca ctactaccgc
     5461 taaccgatgt accggcggcc aggtgtgcgg gggttttgaa ggcggtgccg tcgccggcct
     5521 cgagcaggat gcgggctgcg gtcctgaccc cgatgccggg cacgaggtca ggacccggac
     5581 aagagttcta ttacggaata atcagattca ggaagtacag cagttgcttc tgatgcacgc
     5641 ctccatggaa ccgcccggcg gttgccgaag gggcgcaagc aggcgatacg cacgtcgcga
     5701 cggccagcca gcagggacac ggcgggtcgt ggtgatctca gcctgctgat cagcgtcgac
     5761 tcgtgcagga ggggcggtac accggccgtt cgagcgaggc gagcgggtcc gcctctcctg
     5821 acatccgaga cgccgcggca gatcgtggtg cgacccggtg tccatttgcg ggaaatcagc
     5881 cgggccggac agcttgacgg ctgtccggcc cggttgatcg gcggttgctg ctcagacggt
     5941 ggagtcgtac agcggtccgc cgtcgaccgc cgcggcgccg cgctggtcgt gcgggacgct
     6001 gactttcacc gtgccggtgc aggtgccacc ctggccgtct gccaccgaga agctcacgtg
     6061 gtagacccgg ccgtcgccgg gagctttcgg ggtcccggcc cgttcggcac gcaccttggc
     6121 ggtgtcggtg ccgacgcccg cgccgtccgg ggccgtggcg ccgtcgccag ggccgttgac
     6181 gacctcgtcc tgacggatgc cggtgatctt ggtggtgagg gtgtcgccgt cggggtcggt
     6241 caggcccttg atggtgatcg gcaccatctt gtggttcggc ggccacagca ccgcgtcgct
     6301 gggcgtggcg ccggtgcaga ccggggcgtc gttgaggtcc gcggtggcga ccgtcacgtc
     6361 gtacaggatc gggctctgag ccggttcggt ggtggcccgg gtgaaggtgg cggtgatccg
     6421 caggtaccga ccgtcggcca cgctgaggtc cgcgccgtcg gtcgtgctct gcgtcggccc
     6481 gaaggtcacg ccgtcggagc tgctggcaac cgtgaaggtg agcttgctgt cgctcggggt
     6541 gtccgccgtc cagtcgacgg tgccccactg cgcgcccggg atgccgctgt cgtagaccac
     6601 cgaccaggtg ccggacttcg gcttgccggt gagcgcgctg ccggtcatgt cgctgtagtt
     6661 gtacggtccg gcgcccggca gggcgaccgt caggtcgaac gcgccgatgc gcgtcacgcc
     6721 gtcggtaccg agatctccag cgttcgggtc gatccgggtg gcgtcgctgg agttgatgtt
     6781 ggcggtccag atcttgcccg ccgcgtcgac cgacaccccg gtgctgccgt cgccggcgcc
     6841 ggtgacctcg ccgacgaagg agccgtcgtt cttcaggtgg gcgatgcggt tcgcgccgcc
     6901 gatcaggctg gagctgatcc agacgtggtc gttgccgtcg acggccaggc cctgggcgtt
     6961 cgggtggtgc atggagaacg actggaccgt ggcaccgtcc ggcgacacct tgtagaccag
     7021 ctgcgacgag ttgagcgtgg aggcccagac gttgttctgg ctgtcgaagg cgagaccgta
     7081 cgcgggcacg ttgaggcagc gcgggttcgt ggcggaatcc acggcgttcg ggtcccagcg
     7141 cagcagcgtg gaggcgccca cggcggacca gaggacgccg ttgccgtcga tgaggccgcc
     7201 gtagccgccg cacggcatcg tcctcgccga cccagccacg atggtgccgt ccacgccgtc
     7261 gaccttctgg aaggccctcg aggtggagcc cacccagacg tcgccggccg cgtcgacgct
     7321 caggtgccgg gcgtcggagc cctgcgtgtc cacgtagtgc cggatgcact cgtccagggc
     7381 ggcgctcgcc gcggacgagt tgccgttgct gccacccggc caggccagca cgttgccgta
     7441 acccgtcgag gtctcgatgg tgccgttgcc gttgcggtcc tcgcactggc cggtctcgac
     7501 cagtccgacg tggatgaccg agctctggtt gcggttgccc gcccagacgc tgccgtcgtt
     7561 ggccaccgag gtgcgcgacg ggttgtgcag gttgtcgccg tccgacgtgg tggcgtactc
     7621 gcccttgacc gcaccggtca cggtgtcgat cttcgcgatg gtgccgcggg ccgacaacgc
     7681 cacccagatg aacgggaagg ccgtcacggt gtcgtcgagc tggagctgat ccggcgtgct
     7741 gtggacgacg ttgttggcaa cgccttcgtc gaagtccgca ttcagggtat aagtgtggga
     7801 cgctcccggc gccgcctgcg cgccttggga ggtgagcgcc aacggaacgg caacgagggc
     7861 caatgccgtt ccggcgccga gaactcgcct tcttgcgaac acttcagtgt cctttccgga
     7921 gcagactccg aacgatgaca ggggaatacg ggcgcccgca aagggctgca cgatcgagcg
     7981 gacggcgaaa acgcctccac acggtgatca tcgttcggcc gacattcgga tgtccacctt
     8041 cgacacggct cggacgatcg tccgaacagg gaaaacgttg aactgatccg cccgtatcgg
     8101 tttggcggtt aactccatcg ggtgccgtcg tgcacacgcc aatgagaggc cggttagtga
     8161 gtttgggcgt tagtcatcgc gcgatagcgt ggggatccgt ggggtatgag ggtgggcggc
     8221 tccgggctgc gtcgggcgtg gcgaacgcaa tgctttcccg agtgacctca gcgatgagca
     8281 gtgtgcagtg gtcggcccgt tccgcagctg acgccgttac ggagctgatg gacattcgcg
     8341 ccggcgcctt cacccctgga gtcttaactg aggcgagcct cagcggacct gacctcagca
     8401 gagccacgct ccgcagagct ggccggccgc gtgccactcg ctcgcaactg actctgctcg
     8461 gcagattgct tctcgcggcc gccgctgacc ccaccagctc ccggccgccc tcgacaatcc
     8521 gccatcgatt ctccaggagg tcgcgcggag gtgggtgctg tcgaccaaga tcacttgagc
     8581 ctcgccatcc ggtccggccg ggccggtgcc gtgaaccaca gcgcctccga gcgcccgcgg
     8641 gtgtgcaggc cgtgtccctg ctggccgcag gacccatcgc agctcagccg cccgacgact
     8701 tcccacttgt gctttgctaa cgcttcgttc agccataccg gttggtcgaa cccctggccc
     8761 cactccctag aacgcagtac gaatggcgtc ctggccggag aagggacacg ccctcgactg
     8821 cgaccgtgct ctgacggatt aggcggtaag tatcagtggt gcccagcgct gggcccggtg
     8881 acggcattgc ggcaggtaac aagggcagtg cgcagtgccg tctcggccgc gagggtggag
     8941 gacgtcagtt gctgtagggc taggtcagga agggtgcgga ggccgagcct ggactccgcg
     9001 ttgatgttgg taaggcgagt gcgctgggcg ggagtgatgc cgtccacggg tccccggaag
     9061 ctaagcaggt cgcgcgcggc gtatccgtcg gcggcggcaa ttgtctcctc agcgacctcg
     9121 cggagcagga tggcggccgt gtccgggcga gtggggtagg cgagcgtgac gagagtgagc
     9181 ccgagtcgcg ctcgatagga ggcgtagccg gagactggcc ctcgggcgcg gtagccggct
     9241 agggctacgt cgagctgccg ctcgctgctc agtacaccgg gccgagcgca catcaggttg
     9301 aagcagctga ggacctccaa ttcccagggc tgggtaaggg cgctttcgcc gagcaggttc
     9361 cgggcctgtg ggaggtcgtc gttcaagatg gccgcgatga tggctgcttg gcggccttcc
     9421 atgaggtgta tgccgatgcc cttgtgggcg cgggcgtgct cggcggcagc agtccagcgg
     9481 cccgccagcg cgagcgcccg caccccttcg ccgatgagtt gcagccacac ccattcgcgt
     9541 agctggcgcc gttccagtgg atccccggtg agttcggcgg tcgggaggag atagtcgccg
     9601 acggtgaggt tctggcgtcg ggtgaccgcg tcgtacatcg cctccagcag ttggatggcg
     9661 gcgttgccct ggtcggcgcg gatgtgcaga cgggcgaggt tgaggaccgg ttcgagcagg
     9721 tagcgcgcct ccacgatggt taacgggcgg ccgaggtgcc ggtagacgtg gatgtgctgc
     9781 cagcagagtt gctcggctag gtacggaagg ccgcagtcgc tggcgatcag cgccgccttg
     9841 ttgagggcgt gggcggcgtc agcgaatccc tgctcaccct tctgctcggc ggcagtgacg
     9901 gcgtcggtaa cttcctggat tcgttgcggc aaggcggggc aggccgggcg ggggcggccg
     9961 agcaggggga atcgccgggt ggcggcctgg atggcgtcgt tcatcggacc gactccccag
    10021 gcaggagggc tgacttggcg gcgtgcgcga gaacactctg ggcggtggcg gacagcccga
    10081 gccggttcca gtggaagatc acgacttgag cgaggatcgc ccgtagccct cgctcgagga
    10141 gaccgtcgac cgcgcctcgg cgcagtcgcc gtccggcgtc gatgtgggcg gccagccagg
    10201 gggcggcgta agacagcggt ccgtcggcgg cgaagagcgg gttgtcctct cggaccggca
    10261 tggagaggat ctgctgcatg cgggtcgcca gggcgcctac tcggtcgacg tcatcgatgg
    10321 gaggtcgcat gcgggtgaca cggtcgaaga catcgcctgc ctcaaacggg tcaaggccgg
    10381 cgtgttgttg caacgcccgg acgagcagca gagacagttc tcggcgtccc atggctggcg
    10441 tgtcctgccg gacatagtcg agcacacctc ggctgtccgc gcagaatagg tcgtgcacga
    10501 tgttgatcga gtagtgaccg ccgaacgccc cggtctcggg ttcgtagatg ctctgttgcc
    10561 agcctgcaat gacgccttct ctgacgaggc ggtcaagcag tcctctaact gcgtcgtggt
    10621 gacgggtgcg cactcggagg cgccagtcgg ggtgtttgcg caggaaccac cagccgtatc
    10681 cttcgagccg gtcgaggtgc ggcatgacca gcgtggcgaa ggccggttcg accttgaccc
    10741 agtccagcgg ccggacgtga gcttggaagg tggctcgctc ctggcctttc tgcagggcgg
    10801 cgcgcccggc gttgcggtag gtctccacgg cgtctgccac ttcgagactg tcgtcagccg
    10861 cggcgccacc gaggagagct tcgacatggt ccgcgagctc gtcagcggta cgtgtcagat
    10921 gatcagtaag catgcgtccc acctggtgtg cggttggccg gatcggatcg tgtgcagagt
    10981 cagagcaacg ccggtgcggc cggtcaggaa cccgccgtcg gcatcgcggc ttgctgtggc
    11041 cgtgagccgt tcggcgacgg caggaagctc ctgtgcaatg gcgagggttg tggcgtcggc
    11101 ggcggcccgg taggcggttt ggtaaaggcc ggcgactccg tggcagaggc ccgcatcgct
    11161 cagccggtcg agctgtggac tgaggagaca ggcggcgagt gcctgctcgg cggcggctcg
    11221 gcgcgtgtgg tcggcggtgg cgagggcggc gagttgctgg gcgcgggcga cgcctgccgc
    11281 gccgtagcac catgagggct tgccagggcc atgctggatc gggcggccga tacacaggca
    11341 ctcccgggta acccattgcg gccaccaggg accatgcgcc gtgtcctgct gccattcgtc
    11401 gaaccaggca cacagccgcg agatggcatc ggcctgaccg gtgacctgat gcccgttcag
    11461 atgcgcgtgg gccagcaggg cgaggagccc ggcggcaccg tgggccatgc ctgcgttggc
    11521 gtgcccgcca ggggtaggta gcaacgggtc agggtcgtgg tccacccacc agccgggcac
    11581 cacaaggtcg tcctcccgac gtggctgcgt caggcggacg acgtagtgca gcaggtcgcc
    11641 gagttcgtcg ctgccgggcg cgaggcgcac caggagggta gcgagtccgg tgaggccgta
    11701 gaacaggtcg tactcggcaa acgttgctgg ctggccgctg tcgagtctct cgttggcggt
    11761 tctcaggcgg tcccggatga gccgtcgtag gtgctggtcg agggcggtcc gggcgccgag
    11821 gtagcggtcg tggccgtcgg cggtggtggc gtgcagcgtg aaggcgatag cgggcgcacc
    11881 gtagtacaga ccgacgtggg gggcggcgtc gaccggcccg gcagtggcgg ccttgatgag
    11941 ctgccgcacg gtggcccagt cgccgctgcc atcgagtgcc tgctccaccg ccaacagagc
    12001 agcaccgacg gcgccggagg acagcgattg tgcatcgact tcatctgatg tgacgacggc
    12061 gggagaggcg gtcatcgggt gctcaccggg gcgaggcagc gcatggcgac ggcgcgggcg
    12121 aggtgattgg tcttgcgctc gaactcggga tctacgccga cggcgcggac gtgatgctca
    12181 tgcagcagcg tccgaaggac cactgccgga tcgcgttgct ccctgagccg ggcgtggtag
    12241 gtctgcagcg cgtcctgtct gcggtgccag gcgaccgtga ccacgtcgcc gccgggtagg
    12301 tcccgaaggt gctggtggcc ggcggtcggg tccgcgaggg ttcgagccag ctcggtgagt
    12361 gtgcgatcgg cgggctcagt atggccctta aggcaggtca gcagcgccat gtacccggat
    12421 gcggggtcgg gggcgaaccc ggccgccagc cggaccatcg agacggcggc cagcacgtga
    12481 ctcgggattc ctgcctgctc gctcatgcgg agctggctga tcgcggcggt ggtgtcagcg
    12541 gcgaacacct gctcagccgc ctccatcgca gggccgaggc cgtagcgggc cgggtgcgca
    12601 tggtgcgcgg cgaggaggac ttcggcgggc aagccggact ggtgcagggt gtccgcgaag
    12661 gccgccagcc gggccgcgac cgggccgaac gccgcaggct cccgcaggcg cagctcgatg
    12721 gaaaggtact ggtcggcgtc aaggcggatc atgtcgcggt gccggcgaat ccaccagcgc
    12781 agcagacctc catcgatgag gctgtcggcg agggcgggaa ggtgcttggt cagaagctca
    12841 tcgaagcggg cgggattgcc gatgaggtgc gctcgtacga gcgaggacgc gccggggcgc
    12901 agggtctgcc ctggtgagtc catgacagga agcgggcgcg gtgccggtgc cttcaaggtc
    12961 atggggatga gcagctcggc tgcgtggctg acccagcggt gggcgtctgc aggggcgtct
    13021 tcccggattt cgaggcgttc ggcgcgcgtc agtcggtggt gcagtaaggc ccggtctagc
    13081 gctcggtcga ggtcgagtgg caggcgcagt tcgccgtggc aggcgatcac ccgggcggga
    13141 acgcgccagc gttcccgcca ctcatacagt gccttctccc accgctcaga tggcccgacg
    13201 gtcagcgggc cgtgcgcttg cgcaccggtc gtcgggggcg gtggggcgag gtcggtggcg
    13261 gacagggtcc agcgggcggc ggcgaggatg gtgcgctggt atcggatgcg aggggtatag
    13321 ggcagggttc gggcggcggc gcccaggtcg aagggtccga agaccgcgct gcgcgcgtgg
    13381 cccacctcgg cgatgaatcg ggccagcggc ggggtctgga cggtgatgtc cagggcgtgc
    13441 ggcatgtacg cgaggacgcg tcggccagtg gatcgctgca cgaggtgaag ctgatccggg
    13501 tcagccgtga cggcgaggtc atccacgccg atgtcgtcgc cgtcggggtg ctcgcccagc
    13561 gagatcaccg aggtagtcag tcgacccacc cgcgtgacgt tctggttgtg tacccgtcga
    13621 ggcgggaacg acaggtgtgc cgtgagcgtg ttctcgttgg cggcatcggt gtacgagcgc
    13681 gccagctcgc ctcgtgcggt cgggtcaagc aggtaggcga accgcccggc catgctggtg
    13741 tatgagcggg gcgcgccggt gatgcacagc gcaaacgtcc ccttattcag cgcctccacg
    13801 ctgggggcgt tgaccgtcag actcagctca atgcgggcag gcggcacggc ggcgctcgaa
    13861 tcgccgatcg tcatggcgtc gatgtcggcg tccgtcagcg tgatttcctg ggcaccgtca
    13921 agcgtcgcct gctggatgag ggccaggagg taggcgtcgc gctcggtcag aactcgccag
    13981 gcggggcgtg cccgcggcgc accgaggaag ccacgcgggt agcccagccc cgagtcggcc
    14041 accagctcct tgacgggcac caaggcgccg ggaccgtagc ggtcgcggaa gcgagtgtga
    14101 tagtccagcc aggccgccga cccgaagggc tgcgtggtca accgcagcag cacaccggcc
    14161 gcctgagcag cctcgttcac cacgccggcc ggcacgctga gttcagcatc gagccgaagg
    14221 tccaccacca gcgggtactc gctgccaggg gagagggcag tcatagcttc gaccgcctcc
    14281 gcccggatcg ccgcttgttc acgcaccgtc cgggcagcgt tgtggcgcag cattcgcgcc
    14341 tggatcccgt ccagttgccc caagaccaca gccacctcgg gcagacccgg cccgcccgca
    14401 gcgtgcagaa catcgactac ataggccaag ccatcttcgg cggtcatcgg tgggcgaagg
    14461 ttcgtgatca ggaagccgcc gtcgatcagg ccgtgcagca gtgactcgat ccggtgcggg
    14521 gcggcgtggg aaagctcggt gccgagctgg acggtaagtt cacggaagtg gaccggccgc
    14581 gccgcgtggg ccagtgcccg ttcgacggcg tgggtgaacc gcgtggacgc ttcccgtaat
    14641 ggcccgggtt gacgttcacc ggcttggggc cgcgccgcga tgaccagacg gccatcccgg
    14701 acgatcgccg caccgtccgc gacaacagtt aagacccgcc gcaggtcgtg caggcgttcg
    14761 aggcggtcaa cgaccctggt gagccagtcg gcgtcagcac gcacgacggc ggtgtgctgg
    14821 tcccctaccc ggccggtcgc tgcgcccacc gtggcgatgt tgatcccggc gaagagtgcg
    14881 aagggggtcg ctcgcccctg ccaccgggct aggtaggagg ccaatgcgag taccgcgcgc
    14941 cggaccgcgt tcggtgaagc ggcatcgccg gcgtggacga gttgtccgac tcgctcggcg
    15001 aacgtggggc tcgccatcgt gacggcttcg cgcagctcag gacgagacca ctgttctatg
    15061 agccaggcaa gactccgctc cgagctcccg gtcgcgtcgc tgtcctgcgc gatgtcgccg
    15121 gggtgggtgc tggcacgcag gagtatcggg ccggtcggct ggtactggcg caagttgagg
    15181 ggcatgccat agctccaggc aaaggggtgg tgtgccggaa cccaccaggc gacgggctcc
    15241 ggcgaacggg ggttgtttgt cctggtcagg ccgggtcgta ggaggacgtg ctgcacgcgc
    15301 tggtgctgca ggtgctgccg cagccgtcgc tcgtgctgca catcatgatc accagcggcg
    15361 tggacgactc gatcacgcgc atgtccagct cgaagtcgtc gtcgtccgtg acgaccgtgt
    15421 cggccgggcc atcgaggacc gcgctctgcg gagccatcga gatcactctc cttgcataaa
    15481 aaggggttgg gttcttgcca cctgaatcgc gccgactgaa gtgctcagcc gcgcgcgggc
    15541 caggagatcg tgaggacgcc gtgcgtcttg tccatgacag cgacatctgc cgaacggaga
    15601 gatttctccg tgccggacgg ccagtaggtg aagctcgggt cgcggtgccg accgtcgcgg
    15661 tcccacgcct tgatctgctc gaccatcgcc attgcggcca gctcaccgtc acggccgtac
    15721 gcgctggcac cgaactcgac gccgcccccg tccagcgccg gacgaaccgc gagatacgcg
    15781 aacgccgagc ctcgcacaac accgaacggg aaccacttgc cgtactcggc cgccagctcc
    15841 gtgccctcgt ccaccgccag caggcagaac ccgggcaggt accacgcgaa ccacagatgc
    15901 aggtcggcga acgacacccc gtgcgggatc gtcacccccg accacacctg cacgcgatcg
    15961 gtagcgagca cgctgtcgag cgcgctcatg tcctgcggcg ccccagagtc gaaccgcagc
    16021 ttcacctgct tgccgttggc gtccggtagc aagaacaccc gctccgggtg ctgcccgatc
    16081 ccctgcatgg gcacgaagcc ggccacctca gtcgaggtgc tggcgagggc ctcaccgtcg
    16141 aatcggaagc cgatcgtgcg ggtgactccg ttcatgatca gcggcaagac gagcacaccg
    16201 ccgtccttca actgctccag ccatgcgggc gcgatgtccc aggcgcccac cgtgacgatg
    16261 atcgcgtcga acgggccttc gcccggtagt ccctcagccg catcggcggc gatgacccgc
    16321 acccgcttgc cgtagccggc ctcgtccagc agccgggccg cgcggtcggt gacctccgag
    16381 tcgatgtcca cgctcagcac gtggccttcc ggaccgacga tctccgcgat catcgccgcg
    16441 ttgagacctc ccgaccccac ctccagcacc gacatgcccg gctggagttc ggcctgctcc
    16501 agcatccgag cctggatgta cgcggccgag accgacgaca gggccacgcc gtgcgcatcg
    16561 cgcttggtca ccaccgagtt gtccacgccg tacgcgacct ccagcggcgt gtcagccggg
    16621 aggaaccgtt cccgggccac ggcacggacg gccgcctcca ccgcagcgct ggtgatcttc
    16681 ccgtcggcgc gaagcctttc cacaagcgct gagcgcaact cgcccgcagg gtcagtgcgg
    16741 aggctttccc tagggctggc agccgtatgg gttcggtggt cgtcgtcgtg agactcagtg
    16801 gctggttcgg tcacagggat tcccttcgtt actgacacgt cttgcactac gttctgggag
    16861 ttcatcaagg caatcgcggc gggccggcgc gttggcgaac cttgcaatgt gctcaacggc
    16921 tccgggctgc accgcgccag gagggcgtca gcccatcgag ctgacaaaca cggatgcaac
    16981 gccagccgac cccacgcggc aaggcactcg ccgcaaaacc cgtcctcgtt cgtgtgggcc
    17041 gctgcgacgg cggtggcttg cgccatcaca gcgctcagtg acggatcagc cgagatgccc
    17101 ggctcgctga ggatttgggt gggtcgctcg accgtgctga tctgcatatc aggaccacct
    17161 ccctgtcgga ccggctgttg ctattggcgc gccgggcgaa ggccggcgac ctgcacgaag
    17221 atctttcggc gttcgatcgc cattccatct ccgtccattt ggtagccgtc cagccagcac
    17281 cagccctcgt acgtcggctt gtcgtccact cggatcactc gaaagttgaa gccgatggca
    17341 aactgaacgc tggccgctcg gctgacatgc accatgtcgc ctgcgcggag cctccgaggg
    17401 ccttgctggt cgcctggcat cccgacgcac ctcaacccac ccttgtgaac agggcgcgtg
    17461 catctactcg ccgcgctttg atcagttctg ggcggctcgc accgggcgtc cgttgaggta
    17521 gtcgatgcga gagcttgaag acgttcatgg cctgctcgta ttcatggcac ggtcccggga
    17581 gttcgcaggt cacgcacaat ccggtgccgc tggaagtcag gtgccgctgc aacgccgctt
    17641 gcgcgcagtc aatctgctcg cctcccggat acgtcgtcac atttgctccc tacccgaagg
    17701 ggaccgggcg catcgcgtaa gcatcagcga cgggggtcgc ggtgcgatgc gatgcgcccg
    17761 atccgtcacc caccgccccg gctcgctagc acagaacggc ggggagtcag cctgaatcgt
    17821 ggtgtggccg tacaaacgcg gcccggtcgg accctagggt caccagtagc cgtgtcatca
    17881 cagagtggat cgacaggtcg ccgcgtttcg acggcgcgct agtcgcggat tccgcatctt
    17941 tgtcgcgcgt atgtcgcgtt catgcgtcgc ctggcgcgtc actaatgttg atcagggctg
    18001 atgggctacg gcgccgttac cctgtggaca ccccggacgt gcgttggctg aaggacggga
    18061 actgtgacca cgctgttgaa ggcactgctg cgcgagcggc actggcagaa gtacgtaact
    18121 ttctgcaagg agtgggaccg ggtcgccacc cagctcgatc ccgacctcgt cggcgcctac
    18181 cccagccgat ctcaactcgc ccgatggctg gccggggacc ttaagggcct gcctcacccg
    18241 gacgcatgtc gcatccttga agggctcttc cctggcctcg ccgcgccaca gcttttcgcc
    18301 agcggctcta cgactacggt cctcagcctc tccgggcaac catcgatcct tgtgacgcca
    18361 ccgacttcgg cgccggcgcc cggtcgcagc gacgtaccgt cagaggaggt gctcgccaag
    18421 aaggcgcact ctactgttga cggcacccta ggcgaggaga tcgctatggc tgcggaggag
    18481 tcggcgcgtt tcgtgcgccg agcgcgtggc gctgtgaatc aggacgtact tgatcagcta
    18541 gacgacgatg tccagcagat ggcgcgtgac tacctggctc ggccgccata catgatgttc
    18601 cggcctctgg cacgactacg gacggaagtt tttgagctgc ttgaggagcg gcaacgaccg
    18661 acggtactcc cgggcctcta ccgggtcgct ggccaacttt gcgctctact ggcgcacgcg
    18721 tgcgcggatc ttggtcaggc gtatgccgcc gacacccata cccgtaccgc gtggttatgc
    18781 gcggatcttg ccgagaacaa tccgctccgc gcgtatgtcc gctgggtgca gtcaaacgtc
    18841 gcctactgga acggcgacta ccggcgcgcc gctgagcacg ctcacagcgg ccaacgctac
    18901 gccaccatgg gcaccagcct gcttcggcta gctagccaag aagcgcgagc ccacgccgcc
    18961 gcagcagatc ataaggcggc ggacgcggcg ttgggcacgg cgcaggcggc gcgagcccat
    19021 ctcggcccag gagacgatga gccgggcgga gtttttcgat tcgccccggg taaagcggcc
    19081 tactacgcaa gtgaggttcg cttggcgttg ggcggcaagg agaactaccg acaggccgcg
    19141 actgacgcac agcaagcctt ggaactcttt gccgcccaac cggagtcgga tcactgtccg
    19201 gagttcttcg ctgccgcgca actcgatctc gtagcggccc atcttgcgca agatgatctc
    19261 aacggcgcgg aggagcacct gcttcccgtc ttcgccctac ccacagagag ccgcacgctc
    19321 ccggtggtga agcgagttgc aacgacagac cacgccttgg ccagccaacg cttcgccaac
    19381 gccgccctcg ctgtcgagct gcgcgaacgc atccacctat tctgcgccta cacggcaacc
    19441 cgtgagttgc ctgcactacc ccactgacac cgaccctgga ggcatggcag cgtggccctt
    19501 caagtagccg tatgcggacc ccggtactgc accgacgagg acgccaagcg tgctcgacgc
    19561 gtcggggagc tgctcgccga gcaaggcgcg gtgatcgtct gcggcggagg ggtcggtgtc
    19621 atggctgccg tggcggaggg cgcccgaacc aaaggcggcc tggtcattgg catccgaccc
    19681 aacggcagca aggagggcgc gtcgcccgac ctgtcggcga ccatcgtcac caacatgggg
    19741 gaagcgcgga acgccatcat cgtctggagc gcagatgcag tcatcagcat cggcggctcc
    19801 tggggcaccc tcagcgaggt cgccctcgct atgcggcgcg gtgatgttcc ggtggtggcg
    19861 ctcggtggct ggagagtcgt gcaagcggac ggggaaaccg tccctggcat tcgctatgta
    19921 gacacacccg cagacgctgt ggcggcagca attagcgccg cgcaagaagc accgaagacg
    19981 actgcataac cagatgccga acatcactca cgagtgcgac tacattccgt gtgcgacgac
    20041 gctaccgagc catgccacca gaaacgccgg ccccatcggc gtcactcgac ctgcgcctcg
    20101 aagcttgctc acgaggacaa cggcaggctg gataaggaag gcaccgagga caccggccgc
    20161 cgcggcctgc cagctcaacc agccgaggct taatgcgacg acgcccgcca aggccacgtc
    20221 gcctagcccg agctgtcccg gcagtgacag agccaggatc agcaacgcga cgaccgtcac
    20281 cgagccagcg gtgagcgccc gcagtactgg aaccgaactt ccgcccatga cgacgggcag
    20341 ggtaaagcag atcgtgcacg ccgccgccag cgtgccagtg agggcgtacg ggagccggtg
    20401 acgccgtagg tcggtgatcg ccaagcccac cccaagcacg gcaaaggtcc agaacgcggg
    20461 cagtgtcagc gatagcggga ggcagaccgc gaccagcccg gccgccgcac cagtcaaggc
    20521 cgagacgact gcgacagtcg tcgggcgcgc tggcgcgccg cgccaccacc gttcaggtac
    20581 ccggacgctg ccgcgttctg gtgccgagta cgcgatggcg gcgatgggga caccagcgag
    20641 cgcgccagcg acggcgatgc cgctcgcggc aagagcgttc atcggctacc ggtcgtcctc
    20701 gtcgcggtcg tcggtgcggt gttcccgggt ccaccgttcg agttcggcga gcaggtcgac
    20761 cagttctgtg ccggcgatgg tgaggcggta gtcggcggtg tccgcttcct gatggtgctc
    20821 aaccagccct tcctcctgga ggtgggtcag cgtgcgggtc agggtgcggg cgtggacgac
    20881 ctccaggctt gtctgtgaca cagcatgatg cagcctggag tatcggagcg gtccgtctcg
    20941 gagagcggtc aggatggcca ggttcagctt ccgcctggtg atgttggtcg aggagtgcat
    21001 cgctctgatg gccggcatcc gcaacggcct cctcgtaccg cgggcgtcgt tcttccagat
    21061 caagaacgtt ggagacgcca tcgccgccgg agacccgcaa tggctgaccc agcacgagga
    21121 cgtcatcatc cttcgactcg gccagccgca ggactccgca gacacagagc ccgtcggcgt
    21181 caacgcccac accgaccact ggcttgatgc cttcaccccc gcacgcgtgg atcgacgcgc
    21241 acacccggcg caccccggac atgccaaccc cggccgcagc gcccccgaca cccggcccta
    21301 cccgggtcgg gacactgaaa ggacagccga tccgtgcccg ccctatccac accccatcgc
    21361 cggggccgta cggcccgaca ccaccaccca tcggcggcat accgatcccg acgggccgtg
    21421 tccgcctacc ggtacgcccg acacggcagg ttcgcgatga gcgcctcgac cgtcgccgag
    21481 tggcggcccg accctctcct gaccgtcgat gacgtcgcgg cctggctggg caagccgaaa
    21541 aacaccctct acgcctggca cagccgaggc aagggaccgc gcgccatccg agtcggcaac
    21601 accctgcgct accggcgtag cgaggtagac cgctggctcg actcccacac cgacccggag
    21661 cgctgagcca tggcccgacc tccactaccc gtcggcactt ggggcaagat ccgcacggag
    21721 cagctcggcc ccaaccggca ctgtgcccga gctcgattcc gcgactacga cggcacaacg
    21781 cgcgacgtcg aggccatcgg caccaccggc ccggccgcca ttcgagcact acaggtcaag
    21841 ctgagggacc gtgttgcccc caacgacgac gagatcacca gagaaaccca catcagcaca
    21901 ctcgccgacc tctggctgga cgacatcatc gctgcgggag aagttacgcc acagaccatc
    21961 agccggtacg agatcagcgt ccgcgtctcg atcgtgcctg cgctcggcaa actacgcatc
    22021 cgagaggctg gcgccgggcg tctcgacaag ttcctacgag aggtcgccaa ggaccggccg
    22081 gcagcagcca gaggcgccaa ggtcgccctc cgccagatgt tcgccttggc agtacgccga
    22141 ggggcgctga cgaccaaccc tgtccgcgaa actggccgac tacgtaaccc caggcgcaag
    22201 gtcgtcgtcg cccttgacca cgagcaatta aacggcgtcc gctcggccat ccgcgagtgg
    22261 cagaagccca cccccggcaa gagcggacct cggccgaccg gcgatctggc cgacatcgtc
    22321 gatctcatgc tcgccaccgg cgcccgcatc ggcgagatcc tggccctgcg gtgggaagac
    22381 ctggacctcg ccgacgaacg ccctaccctg accatctgcg gcaccatcgt ctacgtcaaa
    22441 ggcaagggct tctacagaca ggaatggacg aagaccgacg ccggtttccg aagcaccgtc
    22501 ctgccccggt tcgcggtcgg gatgctgatg gcacgcaagc tcaccgccaa cgccaacccc
    22561 aacgatgcga tcttcgcctc tcggcgcggc acctggctat ccccccagaa cttccgccgc
    22621 cagtggcgcc gagtacgcgc cgagaccggg ctcgaatggg tcaccccaca caccttccgc
    22681 aagaccgtcg caaccctcat cgacaaggag gccgacaccg acagcgccgc cgcgcagctc
    22741 ggacacggaa gcaaagaggt cacaaagaag cactacatcg tcaagcccgc gctcgcaccg
    22801 gacaactccg cgatccttga acagctcggc gaccggcggg cgaccgggta gacgagacgc
    22861 cacgcgcgca agatcaccgg tcacagggcg ccgcacgtaa ggaatgaccc gcctctccgg
    22921 taccggccca tcaaaacaac aagcagttct gatgccccga ccacgggtcg gggcatcaga
    22981 ctgtccgggc gagcgggcgc cgcaacccgc gacctccgat gaaatctgcc tgaacctcat
    23041 ggatgtctgc ggtcacccac ttggtggagg agcccgtggg ctgaccgcag atccgacgac
    23101 aaggtaaagg ggagaactcg ccaactagtc cattggttta ggcagcggtt gtaggtttgc
    23161 ttccggctgc ggtcgcgcga gatgtcgctt cggtgtcgtc gttgaggaac tcggcccaga
    23221 tgtgtttggt ggtgtcggtg gcataccagc ccactgcgag ggcgaatttg agggcgagac
    23281 gcaggccgag gccgccggct cctgggggtt gggcgtcggc gaactcgggt gggatctggg
    23341 tgtcgtgatc agcgatgtcc acgatcaggc tgggcccgtc tgcgaacagg cgcacgacgg
    23401 tgggcggcaa tccgtatgtg atggcgttgg cggctaactc ggtggcaacc aacatcatct
    23461 tatcgacagt accgattgcg tattgcgcca acggtctctg ctggatcacg acgtccagca
    23521 gagacgcctt caacgtcggt agctgtgatc gctcgtccag cacccagaca tgcagtacct
    23581 ctgcgtccgc tggaggcagg gtcggtgcga ggttcagcat gtacacaccg tagcgagtca
    23641 gatagggcaa gaataattgc ctatccgcaa acgaatttac cgctacagcg aatgtgggtc
    23701 ggagggcgga tcaggcaggg cgcaaatact tgcctatggt ccactgttgc catatggcac
    23761 gcgtcgcctg tcactatgct ccgatagcgt gaggggcccc gagtcaatgc cgcttcgcgc
    23821 cgaccaacct gacgtcatgg acggaggttg cggacactcc acggtagaag tgcaaagcaa
    23881 cgcccatcga gcagcgcgga tcaggcagcg aacgtcgcca agatccatcg gttgccccta
    23941 cgtcaatgga tatcgatctt ggtgccggga gtgggacagt ggcaacgcag ccatgttcgg
    24001 gtgactcgcc ggatttgtcg cggggaccga cccgttaccc aagtggacgg gagcatgacg
    24061 atggctagta cggatattgg cgccaaactc catggccgct ggtggtgacc tgtgtgcgtc
    24121 gggaggaaag caggctgcga gtccgggtga tcggtgacct ggaggcgtgc gtcgtggctt
    24181 cgtttcgtga ccagatggcg gcgctgttga cagcacccgt ccgggtggtt gacttggatc
    24241 tggcaggggt ggggttctgc gacgcggcag gcgcccggga gctactggcg ttgcgcgatc
    24301 gggctgccca gcagcagatc acggttgtgc tggtggcggc tcaccgggcg gtgcgattgg
    24361 tgttgcacct gtttggcgag cgagcctggg accccgagcc acacgaacgg tagccggcat
    24421 ggcggcaccg gcgctctaca gtagtggacc aaccctgcgc ccggtgtagc aggtgagaac
    24481 cgtgtagcta ccagaggcac cctgctaggc aggatcaccg agtgcccggt aggccgatga
    24541 tgcatccaaa gtgggcgacc agagagcgtt tgcaacgatg ccggtgtggt acagagtgtc
    24601 gaatggtcat ctgtgcccga cgcagcgctg tgtagtgctt gctcacgggt cggccgtaga
    24661 aggatgcacg gatggaattt ggccggtcac cgatactgct gcaacgtcac ctcggcgatg
    24721 acgatcgtat ggtgagggtg atcgccgacg cggacacgat gatcgtcgag gtgacggtca
    24781 gcggccggtg ggaccgccgg ctgcatcagg ccaccgcccg tatcctgcgc ggctgcctcg
    24841 ccgctcatcc tgcagcgatc attatggatc tgcgcgacct tggtgactcc agcggtgcca
    24901 gtgccacgtt gtggccggga gtgcgccagt ggggccagcg ggtgcagccc tcggtgccgg
    24961 tcgtggcgtg ccttcccacc aaggcgccgt gggcccttcg ttgtcggggc gggcgtcaag
    25021 ccgtgccgac gtatgcgagc gtgcccgacg cccgcgccgc cctcatcaac ggccgcacaa
    25081 cacccggcca ggcgcagcca cggctgcgcc tggcacccga tctagcggaa gttgctcaag
    25141 cccgccgact ggtcaccgag gcttgcgcct gctggcagcc atccg
//
