GCF_014645895.1 - 22 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_BMMP01000001.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RRE-containing,azole-containing-RiPP	252,344	287,364
Region 1.2	butyrolactone	425,981	436,964
Region 1.3	NRP-metallophore,NRPS,T1PKS	500,551	591,356	Medium	microtermolide A	NRPS:Type I+PKS

NZ_BMMP01000002.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	butyrolactone	21,390	32,259	Low	griseoviridin/fijimycin A	NRPS:Type I+PKS:Trans-AT type I
Region 2.2	terpene	215,763	242,386	Medium	hopene	terpene

NZ_BMMP01000003.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	NI-siderophore	1	17,778	High	legonoxamine A/desferrioxamine B/legonoxamine B	other:other
Region 3.2	terpene	182,561	206,032	Medium	isorenieratene	terpene
Region 3.3	NRPS-like,NRPS	210,441	260,976	Low	SW-163C/UK-63598/SW-163E/SW-163F/SW-163G	NRPS:Type I

NZ_BMMP01000004.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	RiPP-like	32,201	42,413
Region 4.2	terpene	56,642	77,829

NZ_BMMP01000005.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	lanthipeptide-class-ii	155,261	183,330	High	birimositide	ribosomal:RiPP:Lanthipeptide

NZ_BMMP01000006.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	linaridin	304,663	325,100	Low	BD-12	NRPS:Type I

NZ_BMMP01000007.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	other	207,764	249,278

NZ_BMMP01000010.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	PKS-like,t3nrps-iterative,T1PKS,butyrolactone	22,536	84,906	Medium	4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	PKS
Region 10.2	ectoine	208,212	218,616	High	ectoine	other:ectoine

NZ_BMMP01000012.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	NRPS,NRPS-like	18,565	84,394

NZ_BMMP01000014.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	T1PKS,NRPS-like,NRPS,RiPP-like	1	64,589
Region 14.2	terpene-precursor	74,062	95,216	Low	carotenoid	terpene

NZ_BMMP01000015.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	RiPP-like	1	8,902
Region 15.2	T1PKS,hglE-KS,NRPS	48,725	134,433

NZ_BMMP01000020.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 20.1	linaridin	1,522	22,226	Low	TVA-YJ-2	ribosomal:RiPP

NZ_BMMP01000021.1 (Streptomyces daqingensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	NI-siderophore	5,560	38,583

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RRE-containing,azole-containing-RiPP	252,344	287,364
Region 1.2	butyrolactone	425,981	436,964
Region 1.3	NRP-metallophore,NRPS,T1PKS	500,551	591,356	Medium	microtermolide A	NRPS:Type I+PKS
Region 2.1	butyrolactone	21,390	32,259	Low	griseoviridin/fijimycin A	NRPS:Type I+PKS:Trans-AT type I
Region 2.2	terpene	215,763	242,386	Medium	hopene	terpene
Region 3.1	NI-siderophore	1	17,778	High	legonoxamine A/desferrioxamine B/legonoxamine B	other:other
Region 3.2	terpene	182,561	206,032	Medium	isorenieratene	terpene
Region 3.3	NRPS-like,NRPS	210,441	260,976	Low	SW-163C/UK-63598/SW-163E/SW-163F/SW-163G	NRPS:Type I
Region 4.1	RiPP-like	32,201	42,413
Region 4.2	terpene	56,642	77,829
Region 5.1	lanthipeptide-class-ii	155,261	183,330	High	birimositide	ribosomal:RiPP:Lanthipeptide
Region 6.1	linaridin	304,663	325,100	Low	BD-12	NRPS:Type I
Region 7.1	other	207,764	249,278
Region 10.1	PKS-like,t3nrps-iterative,T1PKS,butyrolactone	22,536	84,906	Medium	4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	PKS
Region 10.2	ectoine	208,212	218,616	High	ectoine	other:ectoine
Region 12.1	NRPS,NRPS-like	18,565	84,394
Region 14.1	T1PKS,NRPS-like,NRPS,RiPP-like	1	64,589
Region 14.2	terpene-precursor	74,062	95,216	Low	carotenoid	terpene
Region 15.1	RiPP-like	1	8,902
Region 15.2	T1PKS,hglE-KS,NRPS	48,725	134,433
Region 20.1	linaridin	1,522	22,226	Low	TVA-YJ-2	ribosomal:RiPP
Region 21.1	NI-siderophore	5,560	38,583

No secondary metabolite regions were found in these records:: NZ_BMMP01000008.1 (Streptomyces daqingensis); NZ_BMMP01000009.1 (Streptomyces daqingensis); NZ_BMMP01000011.1 (Streptomyces daqingensis); NZ_BMMP01000013.1 (Streptomyces daqingensis); NZ_BMMP01000016.1 (Streptomyces daqingensis); NZ_BMMP01000017.1 (Streptomyces daqingensis); NZ_BMMP01000018.1 (Streptomyces daqingensis); NZ_BMMP01000019.1 (Streptomyces daqingensis); NZ_BMMP01000022.1 (Streptomyces daqingensis); NZ_BMMP01000023.1 (Streptomyces daqingensis); NZ_BMMP01000024.1 (Streptomyces daqingensis); NZ_BMMP01000025.1 (Streptomyces daqingensis); NZ_BMMP01000026.1 (Streptomyces daqingensis); NZ_BMMP01000027.1 (Streptomyces daqingensis); NZ_BMMP01000028.1 (Streptomyces daqingensis); NZ_BMMP01000029.1 (Streptomyces daqingensis); NZ_BMMP01000030.1 (Streptomyces daqingensis); NZ_BMMP01000031.1 (Streptomyces daqingensis); NZ_BMMP01000032.1 (Streptomyces daqingensis); NZ_BMMP01000033.1 (Streptomyces daqingensis); NZ_BMMP01000034.1 (Streptomyces daqingensis); NZ_BMMP01000035.1 (Streptomyces daqingensis); NZ_BMMP01000036.1 (Streptomyces daqingensis); NZ_BMMP01000037.1 (Streptomyces daqingensis); NZ_BMMP01000038.1 (Streptomyces daqingensis); NZ_BMMP01000039.1 (Streptomyces daqingensis); NZ_BMMP01000040.1 (Streptomyces daqingensis)

Compact view

NZ_BMMP01000001.1 - Region 1 - RRE-containing,azole-containing-RiPP

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Location: 252,344 - 287,364 nt. (total: 35,021 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

IEY56_RS01245: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Lyases: dehydratase

IEY56_RS01210: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001146.5	0.42	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000603.5	0.35	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001145.5	0.34	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000607.5	0.32	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001640.3	0.31	ribosomal	kocurin	Kocuria rosea
BGC0000606.5	0.31	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0000605.5	0.31	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0001860.4	0.29	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.5	0.28	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0000566.5	0.28	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001146.5	0.53	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000603.5	0.49	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001145.5	0.49	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001472.5	0.48	ribosomal	berninamycin A	Streptomyces bernensis
BGC0001640.3	0.47	ribosomal	kocurin	Kocuria rosea
BGC0000607.5	0.47	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001860.4	0.47	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.5	0.47	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0001174.4	0.47	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000606.5	0.47	ribosomal	lactazole	Streptomyces lactacystinaeus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.71 out of 20.47

Confidence: medium

Additional weak hits (5):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.61 out of 26.33

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.25 out of 20.97

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.34 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.67 out of 26.06

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.93 out of 26.85

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Thiopeptide_F_RRE; Location: 10 - 90; Score: 60.1; RRE type: Heterocycloanthracin_C_RRE; Location: 10 - 94; Score: 38.7
: RRE type: Thiopeptide_F_RRE; Location: 10 - 90; Score: 60.1; RRE type: Heterocycloanthracin_C_RRE; Location: 10 - 94; Score: 38.7

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

Core peptide predictions

No core peptides found.

NZ_BMMP01000001.1 - Region 2 - butyrolactone

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Location: 425,981 - 436,964 nt. (total: 10,984 nt) Show pHMM detection rules used

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: dehydratase

IEY56_RS01920: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.77	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.76	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.38	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001458.4	0.30	other (aminocoumarin)	salinipostin G, Salinipostin G, Salinipostin A, Salinipostin B, Salinipostin C, Salinipostin D, Salinipostin E, Salinipostin F, Salinipostin H, Salinipostin I, Salinipostin J, Salinipostin K	Salinispora tropica CNB-440
BGC0000914.5	0.28	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0001083.5	0.28	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0000038.5	0.25	PKS	coelimycin P1	Streptomyces coelicolor A3(2)
BGC0001771.4	0.25	NRPS	scleric acid	Streptomyces sclerotialus
BGC0000112.5	0.25	PKS	neocarzinostatin	Streptomyces carzinostaticus subsp. neocarzinostaticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.77	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.76	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.38	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001458.4	0.30	other (aminocoumarin)	salinipostin G, Salinipostin G, Salinipostin A, Salinipostin B, Salinipostin C, Salinipostin D, Salinipostin E, Salinipostin F, Salinipostin H, Salinipostin I, Salinipostin J, Salinipostin K	Salinispora tropica CNB-440
BGC0000914.5	0.28	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0001083.5	0.28	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0000038.5	0.25	PKS	coelimycin P1	Streptomyces coelicolor A3(2)
BGC0001771.4	0.25	NRPS	scleric acid	Streptomyces sclerotialus
BGC0000112.5	0.25	PKS	neocarzinostatin	Streptomyces carzinostaticus subsp. neocarzinostaticus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (6):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.62 out of 39.62

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.42 out of 27.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.09 out of 26.06

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.42 out of 18.57

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.76 out of 20.01

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.10 out of 29.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_BMMP01000001.1 - Region 3 - NRP-metallophore,NRPS,T1PKS

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Location: 500,551 - 591,356 nt. (total: 90,806 nt) Show pHMM detection rules used

Region on contig edge.

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

IEY56_RS02265: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IEY56_RS02335: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IEY56_RS02340: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

IEY56_RS02365: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: PPTase aminotransferase

IEY56_RS02230: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

IEY56_RS02240: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: esterase hydrolase

IEY56_RS02220: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

IEY56_RS02250: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

IEY56_RS02300: thioesterase

smcogs: SMCOG1004: thioesterase

IEY56_RS02325: thioesterase

smcogs: SMCOG1004: thioesterase

Isomerases: isomerase

IEY56_RS02310: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

IEY56_RS02245: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS02270: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS02275: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IEY56_RS02320: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

IEY56_RS02345: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

IEY56_RS02350: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS02355: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

IEY56_RS02360: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

IEY56_RS02375: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	1.58	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001164.3	1.54	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001132.4	1.53	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	1.53	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001160.5	1.51	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001825.4	1.50	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	1.50	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	1.49	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	1.46	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	1.42	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001164.3	0.74	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.73	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.73	NRPS	AM-toxin	Alternaria alternata
BGC0001050.5	0.73	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	0.72	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.29 out of 23.79

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (21):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.82 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.20 out of 27.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.96 out of 28.14

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.54 out of 20.97

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.00 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.03 out of 32.74

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.73 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.55 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.95 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.09 out of 30.25

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.65 out of 20.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.18 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.98 out of 33.14

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.23 out of 32.93

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.42 out of 29.65

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.05 out of 26.06

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.40 out of 35.63

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 500550 - 591356:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala - D-Val) + (NH2 - Me-redmal) + (mal) + (Ser) + (ccmal) + (Me-Cys) + (Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IEY56_RS02245: NH2

CAL_domain (162..481): NH2

minowa: NH2

Prediction, score:

NH2: 70.4
fatty_acid: 41.6
Acetyl-CoA: 25.6
shikimic_acid: 0.0
AHBA: 0.0

IEY56_RS02270: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (32..430): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: QMTLFPLACPGGSLQVGGAQQVYGMAEGLLNFTR
Nearest Stachelhaus code(s):: Sal ALPSQGVLNK (91% 8Å match); diOH-Bz PLPSQGVVNK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

IEY56_RS02275: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (566..960): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDVSFDLSVWDGNSLLSGDVGLGGATEAAIWSNC
Nearest Stachelhaus code(s):: Cys DLWNLSLIWK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

IEY56_RS02280: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (548..942): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDIAFDLSVYDGNSLLSGDVSLGGATEAAIWSIH
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

IEY56_RS02345: mal

PKS_AT (547..834): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 170.6
inactive: 88.7
Methoxymalonyl-CoA: 72.3
Methylmalonyl-CoA: 65.9
Propionyl-CoA: 56.6
Ethylmalonyl-CoA: 40.7
CHC-CoA: 33.7
Benzoyl-CoA: 32.9
Isobutyryl-CoA: 29.8
Acetyl-CoA: 26.0
2-Methylbutyryl-CoA: 26.0
fatty_acid: 17.1
trans-1,2-CPDA: 12.9
3-Methylbutyryl-CoA: 0.0

IEY56_RS02350: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (494..891): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFICSGEHNLYGPTEAAIDVTA
Nearest Stachelhaus code(s):: Ser DVWHISLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

IEY56_RS02355: mal

PKS_AT (563..859): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 150.7
inactive: 108.2
Methoxymalonyl-CoA: 81.0
Methylmalonyl-CoA: 69.5
Propionyl-CoA: 42.8
Ethylmalonyl-CoA: 37.2
CHC-CoA: 30.1
2-Methylbutyryl-CoA: 26.7
trans-1,2-CPDA: 23.2
Isobutyryl-CoA: 16.8
Benzoyl-CoA: 16.7
fatty_acid: 15.3
Acetyl-CoA: 13.3
3-Methylbutyryl-CoA: 4.4

IEY56_RS02360: NH2 - mmal

CAL_domain (42..487): NH2

minowa: NH2

Prediction, score:

NH2: 145.1
Acetyl-CoA: 66.0
fatty_acid: 22.4
AHBA: 10.7
shikimic_acid: 0.0

PKS_AT (1239..1541): mmal

ATSignature: Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 70.8%; Propionyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 108.2
Methoxymalonyl-CoA: 100.6
Malonyl-CoA: 92.9
Isobutyryl-CoA: 67.3
Ethylmalonyl-CoA: 65.8
Propionyl-CoA: 60.5
3-Methylbutyryl-CoA: 49.7
Benzoyl-CoA: 43.7
CHC-CoA: 41.6
2-Methylbutyryl-CoA: 41.4
trans-1,2-CPDA: 40.0
inactive: 38.0
Acetyl-CoA: 26.6
fatty_acid: 20.6

IEY56_RS02375: Ala - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (500..892): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LAMTFDIATLELQALICGEWNMYGPSEATIYALG
Nearest Stachelhaus code(s):: Ala DILQLCMIYK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1559..1961): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDHAFDASTYEVFFMAGGETNGYGPTETTTFAVL
Nearest Stachelhaus code(s):: Val DAYFLGGTFK (97% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
IolR	Regulator of the inositol catabolism

NZ_BMMP01000002.1 - Region 1 - butyrolactone

Download region GenBank file

Download region SVG

Location: 21,390 - 32,259 nt. (total: 10,870 nt) Show pHMM detection rules used

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.78	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.70	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.63	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.43	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000885.3	0.33	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000914.5	0.32	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000889.5	0.31	other (other)	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001083.5	0.31	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0000662.5	0.30	terpene	grixazone A	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001513.3	0.30	PKS	anthrabenzoxocinone	Actinobacteria bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.78	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.70	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.63	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.43	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000885.3	0.33	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000914.5	0.32	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000889.5	0.31	other (other)	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001083.5	0.31	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0000662.5	0.30	terpene	grixazone A	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001513.3	0.30	PKS	anthrabenzoxocinone	Actinobacteria bacterium

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.50 out of 20.47

Confidence: medium

Additional weak hits (4):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.25 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.89 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.88 out of 21.84

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.40 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMMP01000002.1 - Region 2 - terpene

Download region GenBank file

Download region SVG

Location: 215,763 - 242,386 nt. (total: 26,624 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IEY56_RS03440: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

Transferases: aminotransferase transferase

IEY56_RS03370: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

IEY56_RS03445: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Ligases: synthetase

IEY56_RS03390: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Translocases: transport

IEY56_RS03415: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.65	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000664.5	0.50	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000859.3	0.48	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000855.3	0.47	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.47	other (other)	ectoine	Methylophaga thalassica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.65	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000664.5	0.50	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000859.3	0.48	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000855.3	0.47	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.47	other (other)	ectoine	Methylophaga thalassica

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

IEY56_RS03385: T2TS

Domain 1 (49 - 684): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

IEY56_RS03390: PT_FPPS_like

Domain 1 (80 - 374): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

IEY56_RS03400: PT_phytoene_like

Domain 1 (9 - 304): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

IEY56_RS03405: PT_phytoene_like

Domain 1 (8 - 283): Prenyltransferase; Phytoene synthase like

Subtype: Hydroxysqualene synthase

Reactions:: PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52

Confidence: medium

Additional weak hits (1):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.71 out of 27.55

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_BMMP01000003.1 - Region 1 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 1 - 17,778 nt. (total: 17,778 nt) Show pHMM detection rules used

Region on contig edge.

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

IEY56_RS05015: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Lyases: decarboxylase

IEY56_RS05020: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001478.5	0.84	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.80	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000941.3	0.79	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.5	0.72	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.71	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.61	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002073.3	0.60	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002690.2	0.58	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001478.5	0.84	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.80	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000941.3	0.79	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.5	0.72	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.71	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.61	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002073.3	0.60	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002690.2	0.58	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.62 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.73 out of 36.53

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (4):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.77 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.58 out of 26.06

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.45 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.14 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
DmdR1	Iron(II)-dependent repressor

NZ_BMMP01000003.1 - Region 2 - terpene

Download region GenBank file

Download region SVG

Location: 182,561 - 206,032 nt. (total: 23,472 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IEY56_RS05920: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.57	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.56	terpene	isorenieratene	Streptomyces argillaceus
BGC0001227.3	0.55	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.55	terpene	carotenoid	Streptomyces avermitilis
BGC0000646.5	0.55	terpene	β-carotein	uncultured bacterium
BGC0000656.5	0.54	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000649.3	0.51	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000650.3	0.48	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000648.3	0.47	terpene	carotenoid	Myxococcus xanthus
BGC0000831.3	0.46	other (other)	violacein	Duganella sp. B2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.57	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.56	terpene	isorenieratene	Streptomyces argillaceus
BGC0001227.3	0.55	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.55	terpene	carotenoid	Streptomyces avermitilis
BGC0000646.5	0.55	terpene	β-carotein	uncultured bacterium
BGC0000656.5	0.54	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000649.3	0.51	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000650.3	0.48	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000648.3	0.47	terpene	carotenoid	Myxococcus xanthus
BGC0000831.3	0.46	other (other)	violacein	Duganella sp. B2

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

IEY56_RS05905: Lycopene_cycl

Domain 1 (21 - 408): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

IEY56_RS05915: PT_phytoene_like

Domain 1 (16 - 311): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 21.07 out of 23.43

Confidence: medium

Additional weak hits (14):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.53 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.89 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.89 out of 27.78

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.43 out of 32.93

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 18.77 out of 33.73

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.18 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.63 out of 21.55

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.47 out of 23.43

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.14 out of 27.78

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.04 out of 27.04

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.40 out of 27.55

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
CRP	Cyclic AMP receptor protein

NZ_BMMP01000003.1 - Region 3 - NRPS,NRPS-like

Download region GenBank file

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Location: 210,441 - 260,976 nt. (total: 50,536 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

IEY56_RS06010: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

IEY56_RS06035: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IEY56_RS06055: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

IEY56_RS06175: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

IEY56_RS06180: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: aminotransferase halogenase

IEY56_RS06060: aminotransferase

smcogs: SMCOG1019: aminotransferase

IEY56_RS06065: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
MITE: MITE0000030Halogenation (identity: 61.50%)
smcogs: SMCOG1119: halogenase

Hydrolases: deacetylase esterase hydrolase

IEY56_RS06050: thioesterase

smcogs: SMCOG1004: thioesterase

IEY56_RS06115: thioesterase

smcogs: SMCOG1004: thioesterase

IEY56_RS06135: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

IEY56_RS06145: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Ligases: ligase

IEY56_RS06045: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS06085: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS06090: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IEY56_RS06095: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.83	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000412.5	0.77	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.66	NRPS	peramine	Epichloe festucae
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000412.5	0.71	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.66	NRPS	peramine	Epichloe festucae
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.88 out of 23.79

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 26.66 out of 30.12

Confidence: medium

Additional weak hits (16):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.99 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.58 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.15 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.34 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.48 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.21 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.04 out of 31.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.38 out of 36.54

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.46 out of 20.97

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.44 out of 36.54

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.07 out of 20.97

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.56 out of 35.63

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.71 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.86 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.47 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 210440 - 260976:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp) + (Cys) + (Cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 210440 - 252210:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp) + (Cys) + (Cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 212325 - 260976:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp) + (Cys) + (Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IEY56_RS06045: X

AMP-binding (32..433): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NACNAALGCPGGTLQVGSSMNVYGIGEGLITHTR
Nearest Stachelhaus code(s):: Hqa ALPTQGWLTK (76% 8Å match); COOH-Qui ALPTQGWLTK (74% 8Å match)
Stachelhaus code match:: 80% (moderate)

IEY56_RS06085: Trp

Search NORINE for peptide: strict or relaxed

AMP-binding (7..400): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTQAFDAWFWDLVLTSTGDFNAYGPTEVTVGASI
Nearest Stachelhaus code(s):: Trp DAWVMTGVGK (85% 8Å match); Kyn DAWTTTGVGK (71% 8Å match)
Stachelhaus code match:: 80% (moderate)

IEY56_RS06090: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (577..975): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDISFDLSVWDGNTLLSGDVALGGATEAAIWSNA
Nearest Stachelhaus code(s):: Cys DLWNLSLIWK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

IEY56_RS06095: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (546..940): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDIAFDLSVYDGNSLLSGDVSLGGATEAAIWSIH
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
OsdR	Development and stress management regulator

NZ_BMMP01000004.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 32,201 - 42,413 nt. (total: 10,213 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli
BGC0000554.4	0.45	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002698.2	0.45	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000589.5	0.41	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli
BGC0000554.4	0.45	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002698.2	0.45	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000589.5	0.41	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.86 out of 23.79

Confidence: medium

Additional weak hits (4):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.18 out of 27.78

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.66 out of 20.97

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.22 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_BMMP01000004.1 - Region 2 - terpene

Download region GenBank file

Download region SVG

Location: 56,642 - 77,829 nt. (total: 21,188 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

IEY56_RS07430: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IEY56_RS07435: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: methyltransferase

IEY56_RS07390: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: cyclase

IEY56_RS07395: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000657.5	0.73	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000659.3	0.63	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000658.3	0.61	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0001910.4	0.51	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001310.5	0.50	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001911.3	0.48	terpene	raimonol	Streptomyces anulatus
BGC0000844.5	0.45	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0001197.5	0.43	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002103.2	0.41	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000657.5	0.73	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000659.3	0.63	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000658.3	0.61	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0001910.4	0.51	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001310.5	0.50	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001911.3	0.48	terpene	raimonol	Streptomyces anulatus
BGC0000844.5	0.45	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0001197.5	0.43	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002103.2	0.41	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
monoterpene		2-methylisoborneol	C11	C1-C6	OH
monoterpene		2-methylenebornane	C11	C1-C6	none

Genes with terpene domains:

IEY56_RS07395: T1TS

Domain 1 (44 - 391): Type 1 terpene synthase

Subtype: 2-Methylisoborneol synthase type

Reactions:: 2-MeGPP → 2-methylisoborneol; 2-MeGPP → 2-methylenebornane

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.52 out of 29.72

Confidence: medium

Additional weak hits (1):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.15 out of 30.25

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
2-MeGPP	2-methylgeranyl diphosphate

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMMP01000005.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

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Location: 155,261 - 183,330 nt. (total: 28,070 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

IEY56_RS09440: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Lyases: cyclase

IEY56_RS09420: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

IEY56_RS09430: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.81	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.76	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5	0.59	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.58	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001311.5	0.53	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000516.4	0.52	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002663.2	0.52	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000909.3	0.51	other (other)	melanin	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.81	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.76	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5	0.59	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.58	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001311.5	0.53	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000516.4	0.52	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002663.2	0.52	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000909.3	0.51	other (other)	melanin	Streptomyces avermitilis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for IEY56_RS09420

IEY56_RS28370

Leader:

MYKGDVSLVEEIAEQDFDGVAYGA

Core:

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDVLGNDhbGGWCysDhbLDhbVECysQPNCysN

antiSMASH-DB 4.0 matches for IEY56_RS28370

100.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

93.3%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide

Lanthipeptides: HCC61_RS30395_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD L NTGGWCTLTVECQPNCN

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

90.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN+GGWCTLT ECQPNCN

1

CTTNTFSLSDALGNSGGWCTLTKECQPNCN

30

with 105 more sequence matches

Only the first 10 are displayed here.

90.0%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN GGWCTLT ECQPNCN

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNCN

30

90.0%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS05175_lanthipeptide

Lanthipeptides: K378_RS05175_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD L N GGWCTLTVECQPNCN

1

CTTNTFSLSDALTNQGGWCTLTVECQPNCN

30

86.7%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

C+TNTFSLSD LGN GGWCTLT ECQPNCN

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

86.7%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN GGWCTLT ECQ NCN

1

CTTNTFSLSDALGNHGGWCTLTKECQANCN

30

86.7%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD +GN GGWCTLT ECQPNCN

1

CTTNTFSLSDAVGNHGGWCTLTKECQPNCN

30

86.7%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN GGWCTLT ECQPNC+

1

CTTNTFSLSDALGNHGGWCTLTKECQPNCS

30

86.7%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN GGWCTLT ECQPNC+

1

CTTNTFSLSDSLGNHGGWCTLTKECQPNCS

30

86.7%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTF+LS+VLGN GGWCTLTVECQPNC

1

CTTNTFTLSNVLGNQGGWCTLTVECQPNCK

30

80.0%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTF+LSD LGN GGWCTLT ECQ +CN

1

CTTNTFTLSDYLGNKGGWCTLTKECQRSCN

30

76.7%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTF+LS+ LGN GGWCTLT ECQ +CN

1

CTTNTFTLSNYLGNNGGWCTLTKECQRSCN

30

MIBiG 4.0 matches for IEY56_RS28370

86.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLS+ LGN GGWCTLT ECQPNCN

1

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

30

50.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDVLGNTGGWCTLTVECQPNCN

30

+++S LGN G +CTLTVEC P+CN

4

YNISCRLGNKGAYCTLTVECMPSCN

28

25.6%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTVECQPNCN

30

CTL+ ECQPNCN

28

CTLSKECQPNCN

39

IEY56_RS09415

Leader:

MSEDILGG

Core:

YDEAELVELSDADAYGGTAWVCATVTLATAAICPTTKCTSQC

Core with dehydrations:

YDEAELVELDhaDADAYGGDhbAWVCysADhbVDhbLADhbAAICysPDhbDhbKCysDhbDhaQCys

antiSMASH-DB 4.0 matches for IEY56_RS09415

100.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATVTLATAAICPTTKCTSQC

42

YDEAELVELSDADAYGGTAWVCATVTLATAAICPTTKCTSQC

1

YDEAELVELSDADAYGGTAWVCATVTLATAAICPTTKCTSQC

42

88.4%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide

Lanthipeptides: K378_RS30040_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDEAELVELSDAD YGGT W ATVTLATAAICPTTKCTSQC

1

YDEAELVELSDADTYGGTGPWCIATVTLATAAICPTTKCTSQC

43

86.0%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide

Lanthipeptides: HCC61_RS01465_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDE ELVELSDAD YGGT W ATVTLATAAICPTTKCTSQC

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

with 104 more sequence matches

Only the first 10 are displayed here.

76.7%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide

Lanthipeptides: OGH68_RS19755_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDEAEL+ELS+AD YGGTA W ATVTL +AA+CPTTKCTS C

1

YDEAELIELSEADTYGGTAAWCIATVTLVSAAMCPTTKCTSAC

43

72.1%

NZ_GG657757.1and 1 other:

NZ_GG657757.1 Lanthipeptides: SSQG_RS41860_lanthipeptide

Lanthipeptides: SSQG_RS41860_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDEAEL+ELS+AD +GGT W ATVTL TA +CPTTKCTS+C

1

YDEAELIELSEADNHGGTGPWCIATVTLVTATVCPTTKCTSKC

43

69.8%

NZ_KL997439.1and 1 other:

NZ_KL997439.1 Lanthipeptides: IQ62_RS33140_lanthipeptide

Lanthipeptides: IQ62_RS33140_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDEAEL+ELS+AD +GGT W ATVTL +A CPTTKCTS C

1

YDEAELIELSEADTHGGTGPWCIATVTLVSAVACPTTKCTSSC

43

65.2%

NZ_AKXV01000031.1and 1 other:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATV----TLATAAICPTTKCTSQC

42

YDE ELVE+ +AD YGGT W CA V TL +A+ CPTTKCTSQC

1

YDEFELVEMGEADVYGGTTWSCAIVTAVATLVSASACPTTKCTSQC

46

65.1%

NZ_BNBV01000031.1and 3 others:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22990_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide

Lanthipeptides: IE286_RS22990_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATVTL-ATAAICPTTKCTSQC

42

YDEAEL+ELS+AD GGT V VT+ A+AA CPTTKCT+ C

1

YDEAELIELSEADVTGGTTPVSIAVTVAASAAFCPTTKCTNDC

43

62.8%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35805_lanthipeptide

Lanthipeptides: TNCT1_RS35805_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATVTL-ATAAICPTTKCTSQC

42

YDEAEL+ELS+AD GGT V VT+ A+ A CPT KCTS C

1

YDEAELIELSEADVTGGTTPVSIAVTVAASVAFCPTIKCTSAC

43

58.1%

NZ_CP016795.1and 7 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS37680_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptide

Lanthipeptides: BC342_RS37680_lanthipeptide

1

YDEAELVELSDADAYGG-TAWVCATVTLATAAICPTTKCTSQC

42

YDEAEL+ELS+AD GG T A A+ A CPTTKCT +C

1

YDEAELIELSEADVTGGTTPVSVAVSVAASVAFCPTTKCTKEC

43

54.5%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15870_lanthipeptide

Lanthipeptides: IE314_RS15870_lanthipeptide

1

YDEAELVELSDADAYGGT-AWVCATVTLATA-AICPTTKCTSQC

42

YDE EL+EL + A+GGT + VC ++A + A CPTTKCTS+C

1

YDELELIELGEDVAHGGTTSPVCIATSVAVSTAFCPTTKCTSKC

44

54.3%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33595_lanthipeptide

Lanthipeptides: LHJ74_RS33595_lanthipeptide

1

YDEAELVELSDADAYGGT------AWVCATVTLATAAICPTTKCTSQC

42

YDEAEL+EL+D++A+GGT +W C +T AT +ICPT+ C+S+C

1

YDEAELIELADSEAFGGTSPATTSSWTC--ITAATISICPTSACSSKC

46

48.1%

NC_016582.1and 1 other:

NC_016582.1 Lanthipeptides: SBI_RS34370_lanthipeptide

Lanthipeptides: SBI_RS34370_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATVTLA------------TAAICPTTKCTSQC

42

+DEAELVELS+AD +GGT + L +AA CPTTKCTS+C

1

WDEAELVELSEADVHGGTDPAVTGLILGIVAIQAGVAVGVSAAFCPTTKCTSRC

54

MIBiG 4.0 matches for IEY56_RS09415

26.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

29

TAAICPTTKCTSQC

42

+AA CPTTKCTS+C

24

SAAFCPTTKCTSRC

37

21.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

32

ICPTTKCTSQC

42

CPTTKCTS+C

16

FCPTTKCTSKC

26

allorf_157684_157821

Leader:

MPRRTPGPQPMHCFRPLIQPSERPPCSRSAAPGG

Core:

PELAPTACYFR

Core with dehydrations:

PELAPDhbACysYFR

antiSMASH-DB 4.0 matches for allorf_157684_157821

100.0%

NZ_BMMP01000005.1:

Lanthipeptides: allorf_157684_157821_lanthipeptide

1

PELAPTACYFR

11

PELAPTACYFR

1

PELAPTACYFR

11

15.6%

NZ_CP031447.1:

Lanthipeptides: allorf_0154490_0154699_lanthipeptide

1

PELAPTACYFR

11

PE PTA Y R

16

PEFHPTAVYVR

26

allorf_157781_157972

Leader:

MGPNSRRPPATSGNSSSVRTWWARGRVGWRASTGRRAPCVHIHGQSFGG

Core:

KSTARNLAGNRRCP

Core with dehydrations:

KDhaDhbARNLAGNRRCysP

antiSMASH-DB 4.0 matches for allorf_157781_157972

100.0%

NZ_BMMP01000005.1:

Lanthipeptides: allorf_157781_157972_lanthipeptide

1

KSTARNLAGNRRCP

14

KSTARNLAGNRRCP

1

KSTARNLAGNRRCP

14

33.3%

NZ_JAASAG010000001.1:

Lanthipeptides: allorf_346027_346167_lanthipeptide

1

KSTARNLAGNRRCP

14

K +ARNLA RCP

14

KLSARNLAVQVRCP

27

12.0%

NZ_KQ061217.1:

Lanthipeptides: allorf_2978446_2978673_lanthipeptide

6

NLAGNRRC

13

N+AG RRC

6

NMAGVRRC

13

with 1 more sequence matches

8.8%

NZ_LMHM01000013.1:

Lanthipeptides: allorf_284297_284530_lanthipeptide

6

NLAGNRRCP

14

NLA R CP

5

NLAAGRECP

13

allorf_157906_158085

Leader:

MQLTIVTVVWGMWSTCEVPGG

Core:

NAQKATLLCGRVTGESGYGHRRFPARFLAVDFPPKLWP

Core with dehydrations:

NAQKADhbLLCysGRVDhbGEDhaGYGHRRFPARFLAVDFPPKLWP

antiSMASH-DB 4.0 matches for allorf_157906_158085

100.0%

NZ_BMMP01000005.1:

Lanthipeptides: allorf_157906_158085_lanthipeptide

1

NAQKATLLCGRVTGESGYGHRRFPARFLAVDFPPKLWP

38

NAQKATLLCGRVTGESGYGHRRFPARFLAVDFPPKLWP

1

NAQKATLLCGRVTGESGYGHRRFPARFLAVDFPPKLWP

38

21.1%

NZ_CAJHJS010000009.1:

Lanthipeptides: allorf_72396_72584_lanthipeptide

26

RFLAVDFPPKLWP

38

R LA +FPPK+ P

4

RALAFNFPPKMCP

16

21.1%

NZ_CP041611.1:

Lanthipeptides: allorf_00810550_00810651_lanthipeptide

17

GYGHRRFPARFLA

29

G HRR P R LA

5

GCRHRRPPVRLLA

17

with 2 more sequence matches

18.4%

NZ_JALBFU010000003.1:

Lanthipeptides: allorf_296607_296801_lanthipeptide

17

GYGHRRFPARFLAVDFPP

34

G RR P R + ++ PP

4

GTCRRRNPERAMGIESPP

21

12.9%

NZ_AP014940.1:

Lanthipeptides: allorf_3261946_3262173_lanthipeptide

16

SGYGHRRFPARF

27

SGYG RRF F

4

SGYGMRRFEVVF

15

allorf_160076_160192

Leader:

MTRGAAEPFS

Core:

VGERARHREHLGPLRSDEEAERTGCRVG

Core with dehydrations:

VGERARHREHLGPLRDhaDEEAERDhbGCysRVG

antiSMASH-DB 4.0 matches for allorf_160076_160192

100.0%

NZ_BMMP01000005.1:

Lanthipeptides: allorf_160076_160192_lanthipeptide

1

VGERARHREHLGPLRSDEEAERTGCRVG

28

VGERARHREHLGPLRSDEEAERTGCRVG

1

VGERARHREHLGPLRSDEEAERTGCRVG

28

29.0%

NZ_AP014940.1and 1 other:

NZ_FNOG01000007.1 Lanthipeptides: allorf_237381_237575_lanthipeptide

Lanthipeptides: allorf_5510480_5510674_lanthipeptide

4

RARHREHLGPLRSDEEAER

22

R RHR L P RS + R

6

RPRHRARLAPGRSQVNSIR

24

17.9%

NZ_CP115450.1:

Lanthipeptides: allorf_7171268_7171477_lanthipeptide

16

SDEEAERTGCRV

27

SD E +R+GCR+

17

SDRETDRSGCRL

28

allorf_162219_162356

Leader:

MKAAERISESAA

Core:

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHDWS

Core with dehydrations:

CysWRRDhbDhaDhaHGLHVRGDhbDDhaQDVPILDhbVPGDMHDWDha

antiSMASH-DB 4.0 matches for allorf_162219_162356

100.0%

NZ_BMMP01000005.1and 1 other:

NZ_BMMP01000005.1 Lanthipeptides: allorf_162219_162356_lanthipeptide

Lanthipeptides: allorf_162219_162356_lanthipeptide

1

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHDWS

33

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHDWS

1

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHDWS

33

78.8%

NZ_FMHJ01000003.1and 1 other:

NZ_FMHJ01000003.1 Lanthipeptides: allorf_511535_511666_lanthipeptide

Lanthipeptides: allorf_511535_511666_lanthipeptide

1

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHD

31

CWRRTSSHGLHVRGT S+DVPILT+PGD++D

1

CWRRTSSHGLHVRGTVSRDVPILTIPGDLYD

31

18.2%

NZ_CP022203.1:

Lanthipeptides: allorf_3832712_3832861_lanthipeptide

20

VPILTVPGDMHD

31

VP++ VPG + D

8

VPVVVVPGCLSD

19

with 1 more sequence matches

16.1%

NZ_CP016076.1:

Lanthipeptides: allorf_2109745_2109951_lanthipeptide

3

RRTSSHGLHVRGTDSQDVPILTVPG

27

RR H RG DS++V + G

30

RRLDGHPSGTRGADSRNVATRSQEG

54

allorf_174812_174928

Leader:

MRACLRVTVARSRIGGPVAGA

Core:

VCFTSATPCGGSVKRSR

Core with dehydrations:

VCysFDhbDhaADhbPCysGGDhaVKRDhaR

antiSMASH-DB 4.0 matches for allorf_174812_174928

100.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: allorf_174812_174928_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: allorf_498973_499089_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: allorf_498973_499089_lanthipeptide

Lanthipeptides: allorf_174812_174928_lanthipeptide

1

VCFTSATPCGGSVKRSR

17

VCFTSATPCGGSVKRSR

1

VCFTSATPCGGSVKRSR

17

Lanthipeptide(s) for IEY56_RS09430

IEY56_RS28370

Leader:

MYKGDVSLVEEIAEQDFDGVAYGA

Core:

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDVLGNDhbGGWCysDhbLDhbVECysQPNCysN

antiSMASH-DB 4.0 matches for IEY56_RS28370

100.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

93.3%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide

Lanthipeptides: HCC61_RS30395_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD L NTGGWCTLTVECQPNCN

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

90.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN+GGWCTLT ECQPNCN

1

CTTNTFSLSDALGNSGGWCTLTKECQPNCN

30

with 105 more sequence matches

Only the first 10 are displayed here.

90.0%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN GGWCTLT ECQPNCN

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNCN

30

90.0%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS05175_lanthipeptide

Lanthipeptides: K378_RS05175_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD L N GGWCTLTVECQPNCN

1

CTTNTFSLSDALTNQGGWCTLTVECQPNCN

30

86.7%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

C+TNTFSLSD LGN GGWCTLT ECQPNCN

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

86.7%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN GGWCTLT ECQ NCN

1

CTTNTFSLSDALGNHGGWCTLTKECQANCN

30

86.7%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD +GN GGWCTLT ECQPNCN

1

CTTNTFSLSDAVGNHGGWCTLTKECQPNCN

30

86.7%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN GGWCTLT ECQPNC+

1

CTTNTFSLSDALGNHGGWCTLTKECQPNCS

30

86.7%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLSD LGN GGWCTLT ECQPNC+

1

CTTNTFSLSDSLGNHGGWCTLTKECQPNCS

30

86.7%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTF+LS+VLGN GGWCTLTVECQPNC

1

CTTNTFTLSNVLGNQGGWCTLTVECQPNCK

30

80.0%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTF+LSD LGN GGWCTLT ECQ +CN

1

CTTNTFTLSDYLGNKGGWCTLTKECQRSCN

30

76.7%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTF+LS+ LGN GGWCTLT ECQ +CN

1

CTTNTFTLSNYLGNNGGWCTLTKECQRSCN

30

MIBiG 4.0 matches for IEY56_RS28370

86.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

CTTNTFSLS+ LGN GGWCTLT ECQPNCN

1

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

30

50.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDVLGNTGGWCTLTVECQPNCN

30

+++S LGN G +CTLTVEC P+CN

4

YNISCRLGNKGAYCTLTVECMPSCN

28

25.6%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTVECQPNCN

30

CTL+ ECQPNCN

28

CTLSKECQPNCN

39

IEY56_RS09415

Leader:

MSEDILGG

Core:

YDEAELVELSDADAYGGTAWVCATVTLATAAICPTTKCTSQC

Core with dehydrations:

YDEAELVELDhaDADAYGGDhbAWVCysADhbVDhbLADhbAAICysPDhbDhbKCysDhbDhaQCys

antiSMASH-DB 4.0 matches for IEY56_RS09415

100.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATVTLATAAICPTTKCTSQC

42

YDEAELVELSDADAYGGTAWVCATVTLATAAICPTTKCTSQC

1

YDEAELVELSDADAYGGTAWVCATVTLATAAICPTTKCTSQC

42

88.4%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide

Lanthipeptides: K378_RS30040_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDEAELVELSDAD YGGT W ATVTLATAAICPTTKCTSQC

1

YDEAELVELSDADTYGGTGPWCIATVTLATAAICPTTKCTSQC

43

86.0%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide

Lanthipeptides: HCC61_RS01465_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDE ELVELSDAD YGGT W ATVTLATAAICPTTKCTSQC

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

with 104 more sequence matches

Only the first 10 are displayed here.

76.7%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide

Lanthipeptides: OGH68_RS19755_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDEAEL+ELS+AD YGGTA W ATVTL +AA+CPTTKCTS C

1

YDEAELIELSEADTYGGTAAWCIATVTLVSAAMCPTTKCTSAC

43

72.1%

NZ_GG657757.1and 1 other:

NZ_GG657757.1 Lanthipeptides: SSQG_RS41860_lanthipeptide

Lanthipeptides: SSQG_RS41860_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDEAEL+ELS+AD +GGT W ATVTL TA +CPTTKCTS+C

1

YDEAELIELSEADNHGGTGPWCIATVTLVTATVCPTTKCTSKC

43

69.8%

NZ_KL997439.1and 1 other:

NZ_KL997439.1 Lanthipeptides: IQ62_RS33140_lanthipeptide

Lanthipeptides: IQ62_RS33140_lanthipeptide

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

YDEAEL+ELS+AD +GGT W ATVTL +A CPTTKCTS C

1

YDEAELIELSEADTHGGTGPWCIATVTLVSAVACPTTKCTSSC

43

65.2%

NZ_AKXV01000031.1and 1 other:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATV----TLATAAICPTTKCTSQC

42

YDE ELVE+ +AD YGGT W CA V TL +A+ CPTTKCTSQC

1

YDEFELVEMGEADVYGGTTWSCAIVTAVATLVSASACPTTKCTSQC

46

65.1%

NZ_BNBV01000031.1and 3 others:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22990_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide

Lanthipeptides: IE286_RS22990_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATVTL-ATAAICPTTKCTSQC

42

YDEAEL+ELS+AD GGT V VT+ A+AA CPTTKCT+ C

1

YDEAELIELSEADVTGGTTPVSIAVTVAASAAFCPTTKCTNDC

43

62.8%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35805_lanthipeptide

Lanthipeptides: TNCT1_RS35805_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATVTL-ATAAICPTTKCTSQC

42

YDEAEL+ELS+AD GGT V VT+ A+ A CPT KCTS C

1

YDEAELIELSEADVTGGTTPVSIAVTVAASVAFCPTIKCTSAC

43

58.1%

NZ_CP016795.1and 7 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS37680_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptide

Lanthipeptides: BC342_RS37680_lanthipeptide

1

YDEAELVELSDADAYGG-TAWVCATVTLATAAICPTTKCTSQC

42

YDEAEL+ELS+AD GG T A A+ A CPTTKCT +C

1

YDEAELIELSEADVTGGTTPVSVAVSVAASVAFCPTTKCTKEC

43

54.5%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15870_lanthipeptide

Lanthipeptides: IE314_RS15870_lanthipeptide

1

YDEAELVELSDADAYGGT-AWVCATVTLATA-AICPTTKCTSQC

42

YDE EL+EL + A+GGT + VC ++A + A CPTTKCTS+C

1

YDELELIELGEDVAHGGTTSPVCIATSVAVSTAFCPTTKCTSKC

44

54.3%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33595_lanthipeptide

Lanthipeptides: LHJ74_RS33595_lanthipeptide

1

YDEAELVELSDADAYGGT------AWVCATVTLATAAICPTTKCTSQC

42

YDEAEL+EL+D++A+GGT +W C +T AT +ICPT+ C+S+C

1

YDEAELIELADSEAFGGTSPATTSSWTC--ITAATISICPTSACSSKC

46

48.1%

NC_016582.1and 1 other:

NC_016582.1 Lanthipeptides: SBI_RS34370_lanthipeptide

Lanthipeptides: SBI_RS34370_lanthipeptide

1

YDEAELVELSDADAYGGTAWVCATVTLA------------TAAICPTTKCTSQC

42

+DEAELVELS+AD +GGT + L +AA CPTTKCTS+C

1

WDEAELVELSEADVHGGTDPAVTGLILGIVAIQAGVAVGVSAAFCPTTKCTSRC

54

MIBiG 4.0 matches for IEY56_RS09415

26.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

29

TAAICPTTKCTSQC

42

+AA CPTTKCTS+C

24

SAAFCPTTKCTSRC

37

21.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

32

ICPTTKCTSQC

42

CPTTKCTS+C

16

FCPTTKCTSKC

26

allorf_162219_162356

Leader:

MKAAERISESAA

Core:

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHDWS

Core with dehydrations:

CysWRRDhbDhaDhaHGLHVRGDhbDDhaQDVPILDhbVPGDMHDWDha

antiSMASH-DB 4.0 matches for allorf_162219_162356

100.0%

NZ_BMMP01000005.1and 1 other:

NZ_BMMP01000005.1 Lanthipeptides: allorf_162219_162356_lanthipeptide

Lanthipeptides: allorf_162219_162356_lanthipeptide

1

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHDWS

33

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHDWS

1

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHDWS

33

78.8%

NZ_FMHJ01000003.1and 1 other:

NZ_FMHJ01000003.1 Lanthipeptides: allorf_511535_511666_lanthipeptide

Lanthipeptides: allorf_511535_511666_lanthipeptide

1

CWRRTSSHGLHVRGTDSQDVPILTVPGDMHD

31

CWRRTSSHGLHVRGT S+DVPILT+PGD++D

1

CWRRTSSHGLHVRGTVSRDVPILTIPGDLYD

31

18.2%

NZ_CP022203.1:

Lanthipeptides: allorf_3832712_3832861_lanthipeptide

20

VPILTVPGDMHD

31

VP++ VPG + D

8

VPVVVVPGCLSD

19

with 1 more sequence matches

16.1%

NZ_CP016076.1:

Lanthipeptides: allorf_2109745_2109951_lanthipeptide

3

RRTSSHGLHVRGTDSQDVPILTVPG

27

RR H RG DS++V + G

30

RRLDGHPSGTRGADSRNVATRSQEG

54

allorf_174812_174928

Leader:

MRACLRVTVARSRIGGPVAGA

Core:

VCFTSATPCGGSVKRSR

Core with dehydrations:

VCysFDhbDhaADhbPCysGGDhaVKRDhaR

antiSMASH-DB 4.0 matches for allorf_174812_174928

100.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: allorf_174812_174928_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: allorf_498973_499089_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: allorf_498973_499089_lanthipeptide

Lanthipeptides: allorf_174812_174928_lanthipeptide

1

VCFTSATPCGGSVKRSR

17

VCFTSATPCGGSVKRSR

1

VCFTSATPCGGSVKRSR

17

allorf_179897_180031

Leader:

MDQNACSTRSRGSGSRPLLTILRMADGG

Core:

SVLCGETRPSRPPVTE

Core with dehydrations:

DhaVLCysGEDhbRPDhaRPPVDhbE

antiSMASH-DB 4.0 matches for allorf_179897_180031

100.0%

NZ_BMMP01000005.1:

Lanthipeptides: allorf_179897_180031_lanthipeptide

1

SVLCGETRPSRPPVTE

16

SVLCGETRPSRPPVTE

1

SVLCGETRPSRPPVTE

16

35.3%

NZ_RBWU01000007.1:

Lanthipeptides: BZB76_RS30440_lanthipeptide

1

SVLCGETRPSR

11

SVLCG + S+

3

SVLCGHSSNSQ

13

26.1%

NZ_SLWR01000002.1:

Lanthipeptides: EV646_RS08070_lanthipeptide

4

CGETRPSRPPV

14

CG RPS V

9

CGSQRPSNLSV

19

with 2 more sequence matches

25.0%

NZ_JACJIA010000018.1:

Lanthipeptides: HNR61_RS42145_lanthipeptide

4

CGETRPSRPPV

14

CG T+PS V

10

CGSTKPSNLSV

20

11.1%

NZ_CP097290.1:

Lanthipeptides: allorf_018559_018753_lanthipeptide

6

ETRPSRPPVT

15

ETRP+ PP

22

ETRPAEPPAA

31

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

Additional weak hits (7):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.07 out of 26.85

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.01 out of 20.97

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.93 out of 27.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.12 out of 29.38

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.21 out of 24.78

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.44 out of 24.78

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.10 out of 30.11

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

IEY56_RS28370 - Class II

Cleavage pHMM score: -3.70

RODEO score: 0

Monoisotopic mass: 3033.4 Da

Molecular weight: 3035.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3053.4 Da N = 1; 3071.4 Da N = 2; 3089.4 Da N = 3; 3107.4 Da N = 4

IEY56_RS09415 - Class II

Cleavage pHMM score: -2.10

RODEO score: 0

Monoisotopic mass: 4178.9 Da

Molecular weight: 4181.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4199.6 Da N = 1; 4217.7 Da N = 2; 4235.7 Da N = 3; 4253.7 Da N = 4; 4271.7 Da N = 5

allorf_157684_157821 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1248.6 Da

Molecular weight: 1249.4 Da

Number of bridges: 1

allorf_157781_157972 - Class II

Cleavage pHMM score: -2.90

RODEO score: 0

Monoisotopic mass: 1506.8 Da

Molecular weight: 1507.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1525.7 Da N = 1

allorf_157906_158085 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 4201.2 Da

Molecular weight: 4203.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4221.8 Da N = 1; 4239.9 Da N = 2

allorf_160076_160192 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 3135.6 Da

Molecular weight: 3137.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3155.4 Da N = 1

allorf_162219_162356 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 3618.8 Da

Molecular weight: 3621.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3639.0 Da N = 1; 3657.0 Da N = 2; 3675.0 Da N = 3; 3693.0 Da N = 4; 3711.1 Da N = 5; 3729.1 Da N = 6

allorf_174812_174928 - Class II

Cleavage pHMM score: -3.40

RODEO score: 0

Monoisotopic mass: 1664.9 Da

Molecular weight: 1665.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1683.9 Da N = 1; 1702.0 Da N = 2; 1720.0 Da N = 3

IEY56_RS28370 - Class II

Cleavage pHMM score: -3.70

RODEO score: 0

Monoisotopic mass: 3033.4 Da

Molecular weight: 3035.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3053.4 Da N = 1; 3071.4 Da N = 2; 3089.4 Da N = 3; 3107.4 Da N = 4

IEY56_RS09415 - Class II

Cleavage pHMM score: -2.10

RODEO score: 0

Monoisotopic mass: 4178.9 Da

Molecular weight: 4181.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4199.6 Da N = 1; 4217.7 Da N = 2; 4235.7 Da N = 3; 4253.7 Da N = 4; 4271.7 Da N = 5

allorf_162219_162356 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 3618.8 Da

Molecular weight: 3621.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3639.0 Da N = 1; 3657.0 Da N = 2; 3675.0 Da N = 3; 3693.0 Da N = 4; 3711.1 Da N = 5; 3729.1 Da N = 6

allorf_174812_174928 - Class II

Cleavage pHMM score: -3.40

RODEO score: 0

Monoisotopic mass: 1664.9 Da

Molecular weight: 1665.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1683.9 Da N = 1; 1702.0 Da N = 2; 1720.0 Da N = 3

allorf_179897_180031 - Class II

Cleavage pHMM score: -4.90

RODEO score: 0

Monoisotopic mass: 1654.9 Da

Molecular weight: 1655.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1673.9 Da N = 1; 1691.9 Da N = 2; 1709.9 Da N = 3

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein

NZ_BMMP01000006.1 - Region 1 - linaridin

Download region GenBank file

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Location: 304,663 - 325,100 nt. (total: 20,438 nt) Show pHMM detection rules used

linaridin: (cypemycin or cypI)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Isomerases: racemase

IEY56_RS11540: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Translocases: transporter

IEY56_RS11535: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

IEY56_RS11550: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001735.5	0.39	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001379.5	0.34	NRPS	BD-12	Streptomyces luteocolor
BGC0002669.2	0.33	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0000197.5	0.30	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0002346.3	0.30	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0002448.2	0.30	NRPS	Q6402A	Streptomyces violaceusniger
BGC0000221.5	0.29	PKS	erdacin	uncultured soil bacterium V167
BGC0002652.2	0.29	other (other), saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7
BGC0001203.4	0.29	NRPS, PKS	Clarexpoxcin A, Clarexpoxcin B, Clarexpoxcin C, Clarexpoxcin D, Clarexpoxcin E	uncultured bacterium AR_456
BGC0000248.5	0.28	PKS	α naphtocyclinoic acid, fogacin	Streptomyces arenae DSM 40737

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001735.5	0.39	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001379.5	0.34	NRPS	BD-12	Streptomyces luteocolor
BGC0002669.2	0.33	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0000197.5	0.30	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0002346.3	0.30	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0002448.2	0.30	NRPS	Q6402A	Streptomyces violaceusniger
BGC0000221.5	0.29	PKS	erdacin	uncultured soil bacterium V167
BGC0002652.2	0.29	other (other), saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7
BGC0001203.4	0.29	NRPS, PKS	Clarexpoxcin A, Clarexpoxcin B, Clarexpoxcin C, Clarexpoxcin D, Clarexpoxcin E	uncultured bacterium AR_456
BGC0000248.5	0.28	PKS	α naphtocyclinoic acid, fogacin	Streptomyces arenae DSM 40737

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.38 out of 19.26

Confidence: medium

Additional weak hits (4):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.67 out of 18.57

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.48 out of 27.55

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.13 out of 30.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.04 out of 21.55

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_BMMP01000007.1 - Region 1 - other

Download region GenBank file

Download region SVG

Location: 207,764 - 249,278 nt. (total: 41,515 nt) Show pHMM detection rules used

other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IEY56_RS12660: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002573.2	0.59	other (other)	phosphoramidon	Streptomyces mozunensis
BGC0000888.5	0.45	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.43	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000902.4	0.42	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.40	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0002621.2	0.39	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0002407.3	0.38	other (other), saccharide	angustmycin A, angustmycin C	Streptomyces angustmyceticus
BGC0001336.5	0.36	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000041.3	0.35	PKS	oronofacic acid	Pseudomonas syringae
BGC0002525.3	0.35	PKS	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002573.2	0.59	other (other)	phosphoramidon	Streptomyces mozunensis
BGC0000888.5	0.45	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.43	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000902.4	0.42	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.40	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0002621.2	0.39	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0002407.3	0.38	other (other), saccharide	angustmycin A, angustmycin C	Streptomyces angustmyceticus
BGC0001336.5	0.36	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000041.3	0.35	PKS	oronofacic acid	Pseudomonas syringae
BGC0002525.3	0.35	PKS	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.63 out of 27.78

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.33 out of 23.79

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 19.46 out of 20.01

Confidence: strong

Additional weak hits (12):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.18 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.74 out of 29.38

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.48 out of 27.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.53 out of 27.78

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.93 out of 39.62

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.16 out of 29.38

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.87 out of 24.78

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.74 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.38 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.88 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMMP01000010.1 - Region 1 - PKS-like,T1PKS,butyrolactone,t3nrps-iterative

Download region GenBank file

Download region SVG

Location: 22,536 - 84,906 nt. (total: 62,371 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)
t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

IEY56_RS16055: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IEY56_RS16065: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

IEY56_RS28495: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

IEY56_RS28500: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: PPTase

IEY56_RS16110: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase phosphatase

IEY56_RS16020: thioesterase

smcogs: SMCOG1004: thioesterase

IEY56_RS16070: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

Lyases: decarboxylase

IEY56_RS16040: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase synthase

IEY56_RS16030: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

IEY56_RS16035: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS16075: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS16090: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IEY56_RS16095: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Translocases: transport transporter

IEY56_RS15980: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

IEY56_RS16050: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	0.94	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.91	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.91	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.90	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001250.4	0.86	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.86	NRPS	epichloenin A	Epichloe festucae
BGC0001160.5	0.86	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.86	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000307.4	0.86	NRPS	AbT1	Aureobasidium pullulans
BGC0002154.2	0.86	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001250.4	0.62	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.24 out of 19.26

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 26.07 out of 30.12

Confidence: medium

Additional weak hits (12):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.19 out of 21.55

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.15 out of 18.57

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.88 out of 25.75

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.33 out of 30.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.48 out of 28.19

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.89 out of 30.11

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.70 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.05 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.71 out of 27.78

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.10 out of 35.63

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 24.27 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 22535 - 84906:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 23620 - 84906:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IEY56_RS16035: X

AMP-binding (27..426): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AAVVFDYGLYQLPLTNTGAAPMYGTTECKRITIL
Nearest Stachelhaus code(s):: Asp DYYPTTMRVK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

IEY56_RS16075: NH2

CAL_domain (40..483): NH2

minowa: NH2

Prediction, score:

NH2: 164.4
fatty_acid: 40.5
AHBA: 13.2
shikimic_acid: 6.7
Acetyl-CoA: -1.8

IEY56_RS16090: mal

PKS_AT (528..811): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 154.9
inactive: 88.4
Methoxymalonyl-CoA: 84.2
Methylmalonyl-CoA: 70.6
Propionyl-CoA: 59.3
Ethylmalonyl-CoA: 45.4
2-Methylbutyryl-CoA: 34.4
trans-1,2-CPDA: 25.8
fatty_acid: 24.6
Isobutyryl-CoA: 23.4
Acetyl-CoA: 19.4
Benzoyl-CoA: 17.0
CHC-CoA: 11.4
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
OsdR	Development and stress management regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMMP01000010.1 - Region 2 - ectoine

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Location: 208,212 - 218,616 nt. (total: 10,405 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IEY56_RS16720: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase

IEY56_RS16740: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.85	other (other)	ectoine	Streptomyces anulatus
BGC0000856.3	0.72	other (other)	ectoine	Methylophaga thalassica
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.62	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.85	other (other)	ectoine	Streptomyces anulatus
BGC0000856.3	0.72	other (other)	ectoine	Methylophaga thalassica
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.62	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.89 out of 23.79

Confidence: medium

Additional weak hits (5):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.16 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.64 out of 31.73

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.79 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.27 out of 26.06

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_BMMP01000012.1 - Region 1 - NRPS,NRPS-like

Download region GenBank file

Download region SVG

Location: 18,565 - 84,394 nt. (total: 65,830 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase electron transfer

IEY56_RS18375: flavodoxin

smcogs: SMCOG1134: flavodoxin

IEY56_RS18435: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

IEY56_RS18455: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: aminotransferase

IEY56_RS18350: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: phosphatase

IEY56_RS18450: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

Isomerases: mutase

IEY56_RS18500: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: ligase synthase

IEY56_RS18425: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS18430: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS18440: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IEY56_RS18445: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEY56_RS18465: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.82	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.66	NRPS	peramine	Epichloe festucae
BGC0001833.4	0.65	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000342.4	0.65	NRPS	enniatin	Fusarium equiseti
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.68	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001133.4	0.67	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.74 out of 20.47

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.33 out of 19.52

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72

Confidence: medium

Additional weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.32 out of 30.25

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.94 out of 33.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.04 out of 29.65

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.75 out of 29.65

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.95 out of 26.06

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.20 out of 30.11

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 18564 - 84394:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (mal) + (D-Ala) + (Thr - D-Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 18564 - 75591:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (mal) + (D-Ala) + (Thr - D-Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 42417 - 84394:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (mal) + (D-Ala) + (Thr - D-Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IEY56_RS18425: Thr - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (507..917): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LEAHFDFSVWEGNQVFGGEVNMYGITETTVHASR
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1640..2047): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDGSFDASTFEGWLWTGGDVNGYGPTETTTFATR
Nearest Stachelhaus code(s):: Val DAYWWGGTFK (91% 8Å match)
Stachelhaus code match:: 90% (moderate)

IEY56_RS18430: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (478..900): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: LWATFDVSVAEPCA-MAGEMNVYGPTEATVYATA
Nearest Stachelhaus code(s):: Ala DVFSVAVVYK (76% 8Å match)
Stachelhaus code match:: 70% (weak)

IEY56_RS18445: X

AMP-binding (28..440): X

nrpys: Tyr, bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SPRRFDGMLGGWIVVVAGEVNEYGPTETTISCTV
Nearest Stachelhaus code(s):: Trp DVGIVGEITK (56% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

NZ_BMMP01000014.1 - Region 1 - NRPS,NRPS-like,RiPP-like,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 64,589 nt. (total: 64,589 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

IEY56_RS20505: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IEY56_RS20520: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: aminotransferase methyltransferase

IEY56_RS20495: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

IEY56_RS20545: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: esterase

IEY56_RS20425: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: lyase

IEY56_RS20420: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

IEY56_RS20450: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

IEY56_RS20470: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

IEY56_RS20560: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Isomerases: racemase

IEY56_RS20475: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: ligase synthase

IEY56_RS20430: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IEY56_RS20500: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IEY56_RS20540: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.87	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.86	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3	0.86	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002135.2	0.85	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825.4	0.84	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000357.5	0.83	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0000307.4	0.83	NRPS	AbT1	Aureobasidium pullulans
BGC0001250.4	0.82	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.82	NRPS	epichloenin A	Epichloe festucae
BGC0001240.4	0.82	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.65	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3	0.65	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.64	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 26.50 out of 30.12

Confidence: medium

Additional weak hits (19):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.75 out of 32.74

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.02 out of 18.57

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.33 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.67 out of 30.25

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.01 out of 20.97

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.33 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.38 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.18 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.76 out of 29.38

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.70 out of 20.97

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.12 out of 27.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.96 out of 28.19

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.13 out of 24.78

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.62 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 30.98

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.97 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.11 out of 29.65

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 64589:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (His) + (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 44539:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (His) + (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 21499 - 64589:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (His) + (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IEY56_RS20430: mal

PKS_AT (557..840): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 143.8
Methoxymalonyl-CoA: 67.9
inactive: 54.8
Methylmalonyl-CoA: 50.7
Propionyl-CoA: 39.0
CHC-CoA: 29.1
fatty_acid: 26.2
2-Methylbutyryl-CoA: 25.0
trans-1,2-CPDA: 20.8
Isobutyryl-CoA: 19.0
Benzoyl-CoA: 17.4
Ethylmalonyl-CoA: 14.7
Acetyl-CoA: 13.9
3-Methylbutyryl-CoA: 0.0

IEY56_RS20435: His

Search NORINE for peptide: strict or relaxed

AMP-binding (253..647): His

nrpys: His

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AARSFDSSAAAGLCITAGEVNEYGPTETTVWASY
Nearest Stachelhaus code(s):: His DSALIAEVWK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

IEY56_RS20500: X

AMP-binding (14..404): X

nrpys: Ile, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LAGAWDAFSLEGWLMTGGEVNGYGPVESTVFATT
Nearest Stachelhaus code(s):: Ile or Val DALWMGGVFK (62% 8Å match); Val DALWMGGVFK (53% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
OsdR	Development and stress management regulator

NZ_BMMP01000014.1 - Region 2 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 74,062 - 95,216 nt. (total: 21,155 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IEY56_RS20710: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: methyltransferase

IEY56_RS20645: methyltransferase

smcogs: SMCOG1089: methyltransferase

IEY56_RS20670: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: peptidase

IEY56_RS20635: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

IEY56_RS20675: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001456.3	0.43	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.43	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.43	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000664.5	0.39	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001456.3	0.43	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.43	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.43	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000664.5	0.39	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

IEY56_RS20675: PT_FPPS_like

Domain 1 (67 - 380): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.56 out of 21.84

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.29 out of 24.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.86 out of 32.93

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_BMMP01000015.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 1 - 8,902 nt. (total: 8,902 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IEY56_RS21340: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000306.5	0.32	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0002303.3	0.31	ribosomal	pristinin A3	Streptomyces pristinaespiralis
BGC0002387.2	0.30	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0002788.2	0.29	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0001377.5	0.28	PKS	uncialamycin	Streptomyces uncialis
BGC0000874.5	0.28	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0001060.5	0.26	PKS	dynemicin A	Micromonospora chersina
BGC0000241.5	0.25	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.25	PKS	nenestatin	Micromonospora echinospora
BGC0000240.5	0.24	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000306.5	0.32	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0002303.3	0.31	ribosomal	pristinin A3	Streptomyces pristinaespiralis
BGC0002387.2	0.30	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0002788.2	0.29	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0001377.5	0.28	PKS	uncialamycin	Streptomyces uncialis
BGC0000874.5	0.28	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0001060.5	0.26	PKS	dynemicin A	Micromonospora chersina
BGC0000241.5	0.25	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.25	PKS	nenestatin	Micromonospora echinospora
BGC0000240.5	0.24	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (5):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.83 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.22 out of 26.06

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.90 out of 33.73

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.79 out of 19.52

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.50 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_BMMP01000015.1 - Region 2 - NRPS,T1PKS,hglE-KS

Download region GenBank file

Download region SVG

Location: 48,725 - 134,433 nt. (total: 85,709 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
hglE-KS: (hglE or hglD)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

IEY56_RS21510: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

IEY56_RS21540: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

IEY56_RS21670: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

IEY56_RS21755: aldehyde oxidase and xanthine dehydrogenase

smcogs: SMCOG1293: aldehyde oxidase and xanthine dehydrogenase

Transferases: aminotransferase carbamoyltransferase glycosyltransferase

IEY56_RS21525: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

IEY56_RS21575: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

IEY56_RS21695: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: dehalogenase hydrolase

IEY56_RS21580: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

IEY56_RS21735: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

IEY56_RS21740: isochorismatase

smcogs: SMCOG1027: isochorismatase

Lyases: hydratase

IEY56_RS21515: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

IEY56_RS21590: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IEY56_RS21595: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

IEY56_RS21690: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

IEY56_RS28900: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	1.17	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001160.5	1.07	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	1.07	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001254.3	1.01	PKS	ACT-Toxin II	Alternaria alternata
BGC0000041.3	0.77	PKS	oronofacic acid	Pseudomonas syringae
BGC0000869.5	0.71	other (other)	heterocyst glycolipids	Nostoc sp. 'Peltigera membranacea cyanobiont'
BGC0001161.5	0.65	PKS	1-heptadecene	Moorea bouillonii PNG
BGC0001163.3	0.65	PKS	1-heptadecene	Moorea producens 3L
BGC0001162.3	0.65	PKS	1-heptadecene	Moorea producens JHB
BGC0001841.2	0.63	NRPS, PKS	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.64	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001249.5	0.63	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.38 out of 19.26

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.52 out of 19.26

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.75 out of 23.05

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (25):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.52 out of 39.62

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.13 out of 28.14

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.19 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.87 out of 21.55

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.53 out of 32.93

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.68 out of 20.01

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.08 out of 27.78

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.52 out of 36.53

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.56 out of 32.74

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.91 out of 23.43

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.29 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.74 out of 33.14

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.42 out of 23.43

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.81 out of 24.78

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.54 out of 26.12

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.00 out of 35.63

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.14 out of 35.63

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.78 out of 29.65

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.62 out of 29.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.93 out of 29.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.90 out of 28.19

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.08 out of 23.43

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.79 out of 27.04

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 48724 - 134433:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (Val) + (mal) + (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 48724 - 93317:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: IEY56_RS21590 + IEY56_RS21585 + IEY56_RS21595

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 53322 - 100525:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: IEY56_RS21590 + IEY56_RS21585 + IEY56_RS21595

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 85041 - 134433:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IEY56_RS21590: pk

PKS_AT (626..847): pk

ATSignature: (unknown)

No matches above 50%

minowa: inactive

Prediction, score:

inactive: 14.7
3-Methylbutyryl-CoA: 11.5
Methoxymalonyl-CoA: 8.7
Malonyl-CoA: 8.6
fatty_acid: 7.8
Isobutyryl-CoA: 6.8
Methylmalonyl-CoA: 2.8
trans-1,2-CPDA: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

IEY56_RS21595: mal

PKS_AT (1236..1529): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 86.0
inactive: 41.5
Methoxymalonyl-CoA: 37.4
Methylmalonyl-CoA: 30.2
Propionyl-CoA: 20.2
CHC-CoA: 13.9
fatty_acid: 11.2
Ethylmalonyl-CoA: 6.2
2-Methylbutyryl-CoA: 6.1
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

IEY56_RS21695: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (1391..1785): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWHCFDASLLEPMLVCGGEVNIYGPSEVTVLATA
Nearest Stachelhaus code(s):: Val DALFVGIVLK (68% 8Å match)
Stachelhaus code match:: 90% (moderate)

IEY56_RS28900: mal

PKS_AT (587..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 126.4
Methylmalonyl-CoA: 71.3
Methoxymalonyl-CoA: 68.9
inactive: 61.9
CHC-CoA: 46.3
Ethylmalonyl-CoA: 41.5
Propionyl-CoA: 41.2
Isobutyryl-CoA: 36.9
trans-1,2-CPDA: 26.0
fatty_acid: 25.5
2-Methylbutyryl-CoA: 24.3
Acetyl-CoA: 16.5
3-Methylbutyryl-CoA: 12.2
Benzoyl-CoA: 7.8

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
NtrC	Nitrogen regulatory protein C

NZ_BMMP01000020.1 - Region 1 - linaridin

Download region GenBank file

Download region SVG

Location: 1,522 - 22,226 nt. (total: 20,705 nt) Show pHMM detection rules used

Region on contig edge.

linaridin: (cypemycin or cypI)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

IEY56_RS24435: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: methyltransferase

IEY56_RS24425: methyltransferase

smcogs: SMCOG1248: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001735.5	0.53	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001188.3	0.49	ribosomal	legonaridin	Streptomyces sp. CT34
BGC0001226.4	0.43	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002669.2	0.42	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0002698.2	0.42	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000501.3	0.41	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0001660.3	0.41	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001579.4	0.40	ribosomal	duramycin	Streptomyces cinnamoneus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001735.5	0.53	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001188.3	0.49	ribosomal	legonaridin	Streptomyces sp. CT34
BGC0001226.4	0.43	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002669.2	0.42	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0002698.2	0.42	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000501.3	0.41	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0001660.3	0.41	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001579.4	0.40	ribosomal	duramycin	Streptomyces cinnamoneus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.73 out of 27.04

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.23 out of 29.72

Confidence: medium

Additional weak hits (12):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.20 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.79 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.68 out of 30.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.96 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.00 out of 26.06

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.96 out of 20.97

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.63 out of 30.98

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.53 out of 27.04

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.37 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor
NtrC	Nitrogen regulatory protein C
ToxT	Regulator of MSHA biosynthesis

NZ_BMMP01000021.1 - Region 1 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 5,560 - 38,583 nt. (total: 33,024 nt) Show pHMM detection rules used

Region on contig edge.

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

IEY56_RS24865: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: methyltransferase

IEY56_RS24895: methyltransferase

smcogs: SMCOG1248: methyltransferase

Isomerases: mutase

IEY56_RS24860: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.54	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002682.2	0.50	other (other)	aerobactin	Vibrio mimicus
BGC0002305.2	0.49	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0002683.2	0.47	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001498.5	0.46	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.54	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002682.2	0.50	other (other)	aerobactin	Vibrio mimicus
BGC0002305.2	0.49	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0002683.2	0.47	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001498.5	0.46	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.98 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.14 out of 27.18

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 23.31 out of 27.18

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.93 out of 24.78

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46

Confidence: medium

Additional weak hits (12):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.26 out of 39.62

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.92 out of 27.78

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.71 out of 26.85

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.38 out of 28.19

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.32 out of 27.18

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.09 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.77 out of 25.88

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.66 out of 23.43

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.74 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.52 out of 24.78

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.29 out of 18.57

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
NrdR	Represses ribonucleotide reductase encoding genes
RpoN	Regulator of nitrogen assimilation and virulence