LOCUS       NZ_BMMP01000015         8902 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces daqingensis strain CGMCC 4.7178 sequence15, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMP01000015
VERSION     NZ_BMMP01000015.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces daqingensis
  ORGANISM  Streptomyces daqingensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 192813)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 66X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645895.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:14:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,667
            CDSs (total)                      :: 5,602
            Genes (coding)                    :: 5,509
            CDSs (with protein)               :: 5,509
            Genes (RNA)                       :: 65
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 93
            CDSs (without protein)            :: 93
            Pseudo Genes (ambiguous residues) :: 0 of 93
            Pseudo Genes (frameshifted)       :: 35 of 93
            Pseudo Genes (incomplete)         :: 69 of 93
            Pseudo Genes (internal stop)      :: 2 of 93
            Pseudo Genes (multiple problems)  :: 13 of 93
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:17:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 8902
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMP01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..8902
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..8902
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..8902
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2560:3902](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2561..3902
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    59..72
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.22"
                     /tool="antismash"
     misc_feature    complement(59..73)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.83"
                     /tool="antismash"
     gene            complement(75..743)
                     /locus_tag="IEY56_RS21310"
                     /old_locus_tag="GCM10012287_43460"
     CDS             complement(75..743)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088894.1"
                     /locus_tag="IEY56_RS21310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_43460"
                     /product="ABC transporter"
                     /protein_id="WP_189038887.1"
                     /transl_table=11
                     /translation="MSALLGYHTALLMRSQRWLPPMLLYAAVMGIGVQWGQPVLDGLGY
                     AAAGLLPVTAWVVRICLNIEPLAARQCTAAAAGPARVHLAGILAALLLTCVLGAVGAVY
                     VVAVSDPRSSAGHVAVPLLPAVQAGLLAAFTCAFFGAAIGALCNRPLLSNSGVATPASL
                     LAVLLVLVVGGSPANAAVAGLVSASHEGAVTLPWLPAVASLAVAALATWLACSQAGRRG
                     "
     gene            complement(740..1585)
                     /locus_tag="IEY56_RS21315"
                     /old_locus_tag="GCM10012287_43470"
     CDS             complement(740..1585)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657149.1"
                     /locus_tag="IEY56_RS21315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_43470"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_189038888.1"
                     /transl_table=11
                     /translation="MRLDGVGRRYGLRGDWVLREVDLSLPERSLVRFEGGNGSGKSTLL
                     RMLAGVETPTEGQITGRPSCGYVPERFPATMPLTTRGYLTHLGRVHGLSRTVAVRRAGE
                     WLERFGAAGHSDTPLSELSKGTSQKVAVTQALMARPGLLVLDEAWTGLDHDARTVLDHA
                     VAERVAEGATVVFVDHDPGRLAGASDAAYRVEGGRLRPVAEKDGPRRRGGAAGGGKRVR
                     VVAEGPPGQPPPALPASVIAEQLPGGTIVLTAPVAYSDVLLGSLLEQNWYIRSVREESA
                     "
     gene            1644..2375
                     /locus_tag="IEY56_RS21320"
                     /old_locus_tag="GCM10012287_43480"
     CDS             1644..2375
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993753.1"
                     /locus_tag="IEY56_RS21320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_43480"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_229712087.1"
                     /transl_table=11
                     /translation="MIDAQDAQKAEDYALPLVVRLERDAPPALTDALETAARAVLALLA
                     DERSTPGRDFAEPGAVEGEPGTAGEWAEAVRRWEQRDIRKVVRRARGAEWRRAEALPGL
                     TVTGGTASVRVFPPVPVDGWPKDLSRLQVSGTVLEDAQPPARPAAGTAVLWMPPGLEMS
                     AGKAMAQAAHGAQLAWWRLESEGRAAWSAAGFALAVRRAADTAEWESLVRSGLPVVQDA
                     GHTEIAPGTCTVVADHPALDR"
     misc_feature    2457..2474
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     gene            2561..3902
                     /locus_tag="IEY56_RS21325"
                     /old_locus_tag="GCM10012287_43490"
                     /pseudo=""
     CDS             2561..3902
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481895.1"
                     /locus_tag="IEY56_RS21325"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_43490"
                     /product="DUF692 family multinuclear iron-containing
                     protein"
                     /pseudo=""
                     /sec_met_domain="DUF692 (E-value: 2.3e-94, bitscore: 308.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGATDIRATGTRAADTRVRLGTGIGWRPEIADGIEAQPGIDWVEV
                     VAENVCPDHLPEPLLRLSERGTKIVPHGVSLGLGGADRPDPAKLAALAERAEALQAPLV
                     TEHIAFVRAGGGTTGRPRMEAGHLLPVPRTRDALDVLCENVAAAQEALPVPLAVENIAA
                     LVNWPGEEMSEGRFLAELVERTGVQLLIDVANLHTNHVNRGEDPAVALGELPLDALAYV
                     HVAGGFERDGVWHDSHGHPVPQPVLDVLAQLCARTAPPGVLLERDENFPPVAELAAELD
                     GIRAVLAGGGAEAEARHG"
     misc_feature    4066..4081
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            4167..5801
                     /locus_tag="IEY56_RS21330"
                     /old_locus_tag="GCM10012287_43510"
     CDS             4167..5801
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (117-281). E-value:
                     3.7e-16. Score: 51.4. Matches aSDomain:
                     nrpspksdomains_IEY56_RS21330_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824197.1"
                     /locus_tag="IEY56_RS21330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_43510"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_189038890.1"
                     /sec_met_domain="PF00561 (E-value: 1.4e-21, bitscore: 70.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSVALHGALGALVLTAASVVPSGSAPVAAPFPLRDARSTAGTTS
                     ATGTASAAGTASAASAAAAAGIDWTDCPAAEQLPAPVECGKVTVPVDYARPGGEKIRLT
                     VSRRRATGPARQGALLYNPGGPGGNGMSFPMYASAFGDRVWRKLNKAYDFVGYAPRGVG
                     RSAPLTCGESARGRSAARPARSPRDPSAAYKRAMRRKAAAYAAACAARAGDRLDHFTTP
                     DNARDLEVLRAALGSGKLNFVGTSYGSYLGAVYATLFPGRVRRLVLDSVVDPRPGRVWY
                     RSDLEQNIAFERRWLDWKRWVARHHSVYRLGRTPRAVQRQFDKVRATLDAGRVGGSAGR
                     GVGSRQLLADYVRVGYDAGTWPRHAAALSAFRRGDPRPLVAEAAPDRHGAAARANSDAV
                     YNAVKCSDAPWPRDFARWDRDGTAVARRAPFQTWENAWTNLPCAYWHGERSRPVDVGAR
                     PGDLPPVLLLAATRDPATPYEGAVRTWLRLPGSSLVTERGAGTHGVAGGNTCVDRRLTA
                     YLLHGRTPGRAAECAARPAPRPLPDGS"
     aSDomain        4518..5009
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY56_RS21330_Abhydrolase_1.1"
                     /evalue="3.70E-16"
                     /label="IEY56_RS21330_Abhydrolase_1.1"
                     /locus_tag="IEY56_RS21330"
                     /protein_end="281"
                     /protein_start="117"
                     /score="51.4"
                     /tool="antismash"
                     /translation="ALLYNPGGPGGNGMSFPMYASAFGDRVWRKLNKAYDFVGYAPRGV
                     GRSAPLTCGESARGRSAARPARSPRDPSAAYKRAMRRKAAAYAAACAARAGDRLDHFTT
                     PDNARDLEVLRAALGSGKLNFVGTSYGSYLGAVYATLFPGRVRRLVLDSVVDPRPGRVW
                     Y"
     gene            complement(5824..6540)
                     /gene="hemQ"
                     /locus_tag="IEY56_RS21335"
                     /old_locus_tag="GCM10012287_43520"
     CDS             complement(5824..6540)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358855.1"
                     /locus_tag="IEY56_RS21335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_43520"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_189038891.1"
                     /transl_table=11
                     /translation="MTAAPDKAPNAGKKAKDLNEVIRYTLWSVFRLRDVLPEDRTGYAD
                     EVEELFGQLAAKDVTVRGTYDVSGLRADADVMIWWHAESSDALQEAYNRFRRTRLGRAL
                     EPVWSNMALHRPAEFNKSHVPAFVAGEEPRAYVSVYPFVRSYEWYLLPDEDRRRMLADH
                     GKMARGFPDVRANTVPSFSLGDYEWILAFEADELHRIVDLMRHLRGSEARMHVREEVPF
                     YTGRRKPVAELVAGLV"
     gene            complement(6546..7994)
                     /gene="hemG"
                     /locus_tag="IEY56_RS21340"
                     /old_locus_tag="GCM10012287_43530"
     CDS             complement(6546..7994)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358854.1"
                     /locus_tag="IEY56_RS21340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_43530"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_189038892.1"
                     /sec_met_domain="DAO (E-value: 6.3e-09, bitscore: 29.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHVIVIGGGVSGLAAAHRLLAGGASVTLLEASPRLGGKLLTGEVA
                     GTAVDLGAESMLARRPEAVRLAREAGLGDALQPPAVAGAAVWSRGEMCAMPKGHVMGVP
                     GEPEALSGLLSEAGRARVAEDARLPATEVGEDVAIGEYVAARVGREVVDRLVEPLLGGV
                     YAGDAYRISMRAAVPQLYEAARGEPSLLAAVRGLLRAQAETQRQAQPRTQGSAGAPAGS
                     PVFMGLEGGVGRLPGAVARACRDAGAEIRTGVAVRTVRGPRTGTRSGREVVTEAGEVFA
                     ADAVVLAVPAPRAAAILADEVPAAAAELDAVEYASMALVTMAFRRPDIGAPPQGSGFLV
                     PPVDGRTIKASTFSSNKWGWVAASSPGLFVLRTSVGRYGEERVLEQDDADLVELSLRDL
                     REATGLSAAPVDSVVTRWDGGLPQYPVGHTERVERVRRAVGEAGGLAVCGAVYEGVGIP
                     ACVGSGVRAAEQTLARAVPEDERE"
     misc_feature    8462..8477
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.5"
                     /tool="antismash"
ORIGIN
        1 tgcgccgacg atcgacaacg cagtgaggac gcgtgccgga caccgccaac caggcgggat
       61 ttgtcagaca gaacctaacc ccggcgtccc gcctgcgagc aggccagcca cgtcgccagc
      121 gccgccacgg ccagggacgc cacggccggc agccagggca gggtcaccgc gccctcgtgc
      181 gaggcggaca cgaggccggc gaccgcagcg ttcgccgggg agcctcccac gacgaggacg
      241 agcagcaccg ccagcaggct cgccggagtc gcgacccccg agttgctcag cagcgggcgg
      301 ttgcacagcg cgccgatggc cgcgccgaag aacgcgcacg tgaacgcggc cagcagcccg
      361 gcctgcaccg cgggcagcag cggcaccgcc acgtgcccgg ccgaactcct cgggtcgctg
      421 acggccacga cgtagacggc gcccaccgcg ccgaggacgc acgtcagaag cagcgcggcg
      481 aggatgccgg ccagatgcac ccgcgcgggt cccgcggcgg cggcggtgca ctgccgtgcg
      541 gccaggggct cgatgttcag gcagatgcgg acgacccagg ccgtcacggg cagcagcccg
      601 gccgccgcgt acccgagtcc gtccagcacg ggctgccccc actgcacccc gatccccatg
      661 acggcggcgt agagcagcat gggcgggagc cagcgctggg agcgcatcag cagcgccgtg
      721 tggtagccga gcagggcact catgcggatt cctcgcgtac ggaccggatg taccagttct
      781 gctcgagcag gctcccgagc agcacgtcgg agtaggcgac cggagcggtc aggacgatcg
      841 tgccgcccgg cagctgctcc gcgatcaccg aggcgggcag cgccggcggc ggctgcccgg
      901 gcggcccttc ggcgacgacg cgcacgcgct tccccccgcc cgccgcccca ccgcggcggc
      961 gcggtccgtc cttctcggcg acgggccgca accgcccccc ttcgaccctg tacgccgcgt
     1021 cggacgcacc ggcgaggcgc ccggggtcgt ggtcgacgaa gacgactgtc gccccctcgg
     1081 ccacccgctc ggcgacggcg tggtccagca ctgtgcgggc gtcgtggtcg agcccggtcc
     1141 acgcctcgtc cagcacgagc aggccggggc gcgccatcag cgcctgcgtg acggcgacct
     1201 tctggctcgt ccccttggac agttccgaca gcggggtgtc cgagtggccc gcggccccga
     1261 accgctccag ccactcgccg gcccggcgga cggcgacggt cctgctcagg ccgtgcacgc
     1321 ggcccaggtg ggtcaggtag ccgcgcgtcg tgagcggcat ggtggcgggg aagcgttccg
     1381 gtacgtagcc gcaggatggc cgccccgtga tctgcccttc cgtgggggtc tcgacaccgg
     1441 cgagcatccg cagcagcgtc gacttgccgc tgccgttgcc cccttcgaag cgcaccaggc
     1501 tgcgttcggg cagggagagg tccacttcgc gcagcaccca gtctccgcgc aagccgtacc
     1561 ggcggccgac cccgtccagc ctcatgagag ttggtccgat ctcatgtctg ccgacgttag
     1621 cccgtgctgg cagacttcgg tgggtgatcg acgcacagga cgcacagaag gcagaggact
     1681 acgcgctacc gctggtggta cggctcgaac gagacgctcc gcccgccctg accgacgccc
     1741 tggagaccgc tgcccgcgcc gtcctcgccc tcctcgctga cgaacgcagc acccccggcc
     1801 gcgacttcgc ggagccgggc gccgtcgaag gggaacccgg taccgccggg gaatgggcgg
     1861 aggccgtgcg gcggtgggag cagcgcgaca tccgcaaggt cgtacggcgg gcacgcggag
     1921 cggagtggcg ccgcgcggag gcgctgccgg gcctcaccgt caccggcgga acggcgtccg
     1981 tccgcgtctt cccgcctgtc cccgtcgacg gatggcccaa ggacctgtca cggctgcagg
     2041 tttcgggcac cgtcctggag gacgcacagc cgcccgcgcg gcccgcggcg ggaactgcgg
     2101 tgctgtggat gcctcccggg ctggagatgt ccgcgggcaa ggcgatggcg caggccgcgc
     2161 acggagccca actggcctgg tggcggctgg agtcggaggg ccgtgcggcc tggtcggcag
     2221 ccggtttcgc cctcgccgta cgcagggcgg cggacacggc ggagtgggag agcctggtgc
     2281 gcagcggcct ccccgtcgta caggacgcgg gccacaccga gatcgccccg ggcacctgca
     2341 cggtcgtcgc cgatcacccg gcgctggacc gctgatcccg cctgcgcgag gggtgaaagc
     2401 tcaagcaggg ctctgaaaac ccggtgcccg ggattcgggc gcgcgctgcg tggcagtagc
     2461 ccgtagagcg gcacagcagg cgcgggcacc ggatcgcact ggccggtccg caggacgacc
     2521 ggagccgtcg cgctgacggc tccacggggg aggaacgcac atgggggcga cggacatcag
     2581 ggccaccggc acgcgtgccg ccgacacgcg ggtccggctc ggtacgggca tcggctggcg
     2641 gcccgagatc gcggacggca tcgaggcgca gccgggcatc gactgggtcg aggtcgtcgc
     2701 cgagaacgtc tgcccggacc atcttcccga gccgctgctg cgtctgagcg agcgcggaac
     2761 gaagatcgtc ccgcacggcg tctcactcgg cctcggagga gccgaccgcc ccgacccggc
     2821 gaagctcgcg gcgctcgccg agcgcgcgga ggcgctccag gccccgctgg tcaccgagca
     2881 catcgccttc gtacgggccg gcggcggcac cacgggccgg ccgcgcatgg aggcgggcca
     2941 tctgctgccc gtgccgcgca cccgggacgc gctggacgtg ctctgcgaga acgtcgcggc
     3001 agcgcaggag gcgctgccgg tgccgctcgc cgtggagaac atcgccgcgc tcgtcaactg
     3061 gccgggcgaa gagatgagcg agggacgctt cctcgccgaa ctagtggagc gtacgggcgt
     3121 ccagttgctc atcgacgtcg ccaacctgca caccaaccac gtcaaccgcg gcgaggaccc
     3181 ggcggtcgcg ctcggcgaac tccccctcga cgcgctggcg tacgtgcacg tcgcgggcgg
     3241 gttcgagcgg gacggcgtct ggcacgacag ccacggccac ccggtgccgc agcccgtcct
     3301 ggacgtgctc gcgcagctgt gtgcccggac cgcgccgccc ggagtgctgc tggaacgcga
     3361 cgagaacttc ccgcccgtcg ccgagctggc ggccgaactg gacggcatac gcgccgtcct
     3421 cgcgggcggc ggcgcggaag cggaggcccg gcatggctga gacccacccc ggcgacggca
     3481 cctccgctgc tcgtgagcgg ctcgcccgtg cccagaccgc gctgctggcc gcgctggtcg
     3541 cggacggacc cgtgcccgac ggcttcgacg cggaacggct ggccgtgcag cggcgggcgc
     3601 tgatcggcaa gcgggccgac gtcgtcgcga aggtcgcgcc cgaactcccg gagatcctcg
     3661 gcgagaagac cttccgcacc gagttcgccg cctacgcgcg cggccgcccg atggagggcg
     3721 gctaccggcg cgacgccctg gacttcgcac gccgtctgac ggaggagggc agggccgtcg
     3781 accgggccac ccggctgaag gtgcgccgct ggtggctcga acgctccggt gcgacgccgc
     3841 cgcccgaagg ccgggtgcgc cgcgccctgt accggctgcg cgccgcccgg caggcgggct
     3901 gacggcccac gccccgcgac gcgggcggcg ccgcacctgc tgccgccgcc cgcacctccc
     3961 ccgccgcccg cacagaagcg tgggatgtcg ctgcatcgag cgcatcacgc cgacaccgct
     4021 gcgaggtcct ttacttcgcc aactcccgca ctgagcatcc gacttgtcac tcaacgctca
     4081 cgactgccca ctctccgttc ccttccgggg cgggagcccc tccgggcagc gtcagccccc
     4141 gcggacgagt aggaacgagc ctccctgtgc gctcagttgc actccacggc gcactcggcg
     4201 ccctggtgct gacggccgcc tccgtcgtac cgtccggcag cgcaccggta gccgcgccct
     4261 tccccctccg ggacgcccgg tcgaccgccg gcaccacgtc ggccaccggt accgcgtcag
     4321 ccgccggcac cgcatcggcc gcctccgccg ccgcggccgc cgggatcgac tggacggact
     4381 gtcccgccgc cgagcagctt cccgcgccgg tggagtgcgg gaaggtcacc gtccccgtcg
     4441 actacgcgcg ccccgggggc gagaagatcc ggctgaccgt cagcaggcgc agagcgacgg
     4501 gccccgcacg ccagggagcg ctgctctaca accccggcgg ccccggcggc aacggcatga
     4561 gcttcccgat gtacgcgtct gcattcggcg accgcgtatg gaggaagctc aacaaggcgt
     4621 acgacttcgt gggctacgcc ccccgcggcg tcggccggtc cgccccgctc acgtgcgggg
     4681 agagcgcccg cggccggtca gccgcccgcc ccgcccgctc cccgcgcgac ccctccgcgg
     4741 cgtacaagcg ggcgatgcgg cggaaagcgg cggcgtacgc ggcggcttgc gccgcacggg
     4801 cgggcgaccg gctcgaccac ttcaccaccc ctgacaacgc gcgcgacctc gaggtcctgc
     4861 gtgccgcgct gggcagcggc aagctcaact tcgtcggcac ctcgtacggc agttacctgg
     4921 gcgccgtcta cgcgacgctc ttccccgggc gggtgcgccg cctcgtcctg gacagcgtcg
     4981 tcgacccccg gcccggccgc gtctggtacc gctccgacct ggaacagaac atcgccttcg
     5041 aacgccgctg gctcgactgg aagcggtggg tggcccggca ccactccgtc taccggctcg
     5101 gccgcacccc gcgtgccgtg cagcgccagt tcgacaaggt gcgcgccacc ctcgacgccg
     5161 ggcgcgtggg cggatcggcg ggacgcggcg tcggctccag gcaactgctc gccgactacg
     5221 tccgcgtcgg ctacgacgcc ggaacctggc cccggcacgc ggcggccctg tcggcgttcc
     5281 gccgcggcga cccgcggccc ctggtcgcgg aggccgcccc ggaccgccac ggagcagcgg
     5341 cccgggccaa cagcgacgcc gtctacaacg cggtgaagtg ctccgacgcc ccttggccgc
     5401 gcgacttcgc tcgctgggac cgggacggta cggccgtcgc ccgcagggcg ccgttccaga
     5461 cctgggagaa cgcctggacg aacctgccct gcgcgtactg gcacggcgag cggtcacggc
     5521 ccgtggacgt gggagcccgg cccggcgacc ttccccccgt cctgctgctc gccgccaccc
     5581 gcgaccccgc cactccctac gagggcgccg tgcgcacctg gctgcggctg cccggctcgt
     5641 cgctcgtcac agagcggggc gccgggacac acggcgtcgc cggcggcaac acgtgcgtgg
     5701 accgccgtct gacggcgtat ctgctgcacg gcaggacgcc cggacgggca gccgagtgcg
     5761 cggcccgtcc ggcaccgcgg ccgctcccgg acgggagctg accggcagcg gccgcgtgag
     5821 ccgtcagacc agcccggcca cgagctccgc gaccggcttc cgccgccccg tgtagaaggg
     5881 cacctcctcg cgtacgtgca tccgcgcctc cgaaccgcgc aggtgccgca tgaggtcgac
     5941 gatgcggtgc agttcgtcgg cctcgaacgc gaggatccac tcgtagtcgc cgagtgagaa
     6001 ggacggcacg gtgttggccc gtacgtccgg gaagccgcga gccatcttgc cgtggtcggc
     6061 gagcatccgc cgccggtcct cgtcgggcag caggtaccac tcgtaggagc gcacgaacgg
     6121 gtagacgctc acgtacgccc gcggctcctc ccctgccacg aaggccggga cgtgcgactt
     6181 gttgaactcg gcgggacggt gcagcgccat gttcgaccac accggttcca gggcgcggcc
     6241 cagccgcgtg cgccggaagc ggttgtaggc ctcctgcagg gcgtcggacg actcggcgtg
     6301 ccaccagatc atgacgtccg cgtcggcccg cagcccggag acgtcgtagg tgccgcgcac
     6361 cgtgacgtcc ttcgcggcga gctggccgaa cagctcctcc acctcgtccg cgtatccggt
     6421 gcggtcctcg gggagcacgt cccgcagccg gaagaccgac cacagggtgt agcggatgac
     6481 ctcgttgagg tccttggcct tcttgcccgc gttgggcgcc ttgtccggtg cagcagtcat
     6541 gcggcctatt ctcgctcgtc ctccggcacg gcccgcgcga gggtctgctc ggcggcacgc
     6601 acgccgctgc cgacgcaggc ggggatgccg acgccctcgt agacggctcc gcacaccgcc
     6661 agaccgccgg cctccccgac ggcacggcgg acgcgctcca cccgctccgt gtgcccgacg
     6721 gggtactgcg gcaggccgcc gtcccagcgg gtcaccacgc tgtcgacggg ggcggccgag
     6781 agccccgtcg cctcccgcag gtcgcgcagc gacagttcga cgaggtccgc gtcgtcctgc
     6841 tcgagcaccc gctcctcgcc gtaccggccc acggacgtcc gcagcacgaa cagtccgggg
     6901 ctgctcgcgg cgacccagcc ccacttgttg ctggagaagg tcgacgcctt gatggtgcgc
     6961 ccgtcgacgg gaggcacgag gaagccgctg ccctgcggcg gcgccccgat gtcggggcgg
     7021 cggaacgcca tcgtcacgag ggccatcgac gcgtactcga cggcgtccag ctcggcagcc
     7081 gccgcgggca cctcgtccgc gaggatcgcc gccgcccgag gggcgggcac cgcgagcacg
     7141 acggcgtcgg cggcgaacac ctcgccggcc tccgtgacga cctcccggcc ggagcgggtg
     7201 cccgtccggg gaccgcggac cgtgcgtacg gcgacaccgg tgcggatctc ggcgcccgcg
     7261 tcgcggcagg cacgggcgac ggctcccggc aggcgcccca cgccgccctc cagccccatg
     7321 aacaccggcg accccgcggg ggccccggca gaaccctgcg ttcgtggttg tgcctggcgc
     7381 tgtgtctccg cctgtgcccg cagcagtccg cgtaccgccg ccagcagcga gggctcgccc
     7441 cgcgccgcct cgtacagctg cggcaccgcc gcacgcatcg agatgcggta cgcgtctccc
     7501 gcgtacaccc cgcccagcag cggctcgacc agccggtcca cgacctcgcg tcccacacgg
     7561 gcggcgacgt actcgccgat cgcgacgtcc tcgccgacct ccgtcgccgg cagccgggcg
     7621 tcctccgcga cgcgggcgcg gccggcctcg gagagcagac cgctcagcgc ctccggttcg
     7681 cccggcacgc ccatcacgtg ccccttcggc atggcgcaca tctcgccccg cgaccagaca
     7741 gccgcgccgg cgaccgccgg cggctgcagc gcgtcgccca gtccggcctc ccgcgccagc
     7801 cgcacagcct cgggcctgcg ggcgagcatc gactccgcgc ccaggtcgac ggccgtcccg
     7861 gccacctccc cggtcaggag cttcccgccg agccgcggcg aagcctccag cagggtcacg
     7921 gacgcgccgc cggcgagcag ccggtgtgcc gcggcgagcc cggagacacc gccgccgatg
     7981 acgatcacat gcatgcggaa actgttgcac ggggtacgac ccgcaaggca gtggggaccg
     8041 gcgtaccggg gcacccgctc acaccggcac gggtcccgga cacgccctcg gcacggcgcc
     8101 cgcgcccacg agacggaggg agcacgcacc atggccgctg cacgccggat ggtcgtcgtc
     8161 ggaggtgacg cggcggggat gtcggccgcg tcccaggccc gcaggctcaa gggcccggac
     8221 gagctggaga tcatcgcgtt cgagcgcggc gacttcacct cgtactcggc gtgcggcatc
     8281 ccgtactgga tcggcgggtc ggtcgactcg cgcgacgacc tcatcgcccg tacgcccgaa
     8341 gcgcaccgcg aacgcgggat cgacctgcgc atgcgcaccg aggtcacgcg gatcgacgtg
     8401 gacggcggac gggtcctcgc ccgcggcctg tcgggggacg gcggtgagga gtggaccggc
     8461 ttcgacgaac tggtcgtcgc cacgggagcc gcccccctgc gtccaccgct ccccggcatc
     8521 gacgccccgg gcgtgcacgc cgtgcagacc ctggaggacg gcgaggccct gctcggcacc
     8581 ctgggcggcg tggagtccgg gtccggcggc gagcggcggc gggccgtcgt cgtcggcgcc
     8641 ggctacatcg gcgtggagat ggccgaggcg ctgaccctgc ggggctacga ggtcacggtc
     8701 ctcgaccagg ccgaacagcc gatgaccact ctcgacccgg acatgggcgc actggtgcgc
     8761 gacgcgatgt gcggaatggg catggaggtc gtcacgggcg ccgaggtcac cgcggtcgag
     8821 accgacggga agggacgcgc ccgcgccgtc accgccgggg agcggaccta ccccgcggac
     8881 gtggtggtgc tgggcctggg cg
//
