LOCUS       NZ_BMMP01000010        10405 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces daqingensis strain CGMCC 4.7178 sequence10, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMP01000010
VERSION     NZ_BMMP01000010.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces daqingensis
  ORGANISM  Streptomyces daqingensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 280247)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 66X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645895.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:14:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,667
            CDSs (total)                      :: 5,602
            Genes (coding)                    :: 5,509
            CDSs (with protein)               :: 5,509
            Genes (RNA)                       :: 65
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 93
            CDSs (without protein)            :: 93
            Pseudo Genes (ambiguous residues) :: 0 of 93
            Pseudo Genes (frameshifted)       :: 35 of 93
            Pseudo Genes (incomplete)         :: 69 of 93
            Pseudo Genes (internal stop)      :: 2 of 93
            Pseudo Genes (multiple problems)  :: 13 of 93
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:17:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 208211
            Orig. end                         :: 218616
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMP01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10405
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="2"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10405
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10405
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5405](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5405)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(315..1085)
                     /locus_tag="IEY56_RS16715"
                     /old_locus_tag="GCM10012287_34090"
     CDS             complement(315..1085)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381154.1"
                     /locus_tag="IEY56_RS16715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_34090"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_189037986.1"
                     /transl_table=11
                     /translation="MSAGETGASQVKSAVRTVELLEFFAGRPGMHSLASVQEAVGYPKS
                     SLYMLLRTLVDLGWVETDSTGTRYGIGVRALLVGTSYIDGDEAVAAARPTLDRLSEDTT
                     ETIHLARLDGTNVVYLATRQSQHYLRPFTRVGRRLPAHSTSLGKALLATYDDEQVREML
                     PEKLPALTEHTVTDREALIRQLALVREQGYAVDREENTLGLRCFGVAIPYRTPARDAVS
                     CSVPVARLTPAHEQMIRDALFDARDRLTMATRRL"
     gene            1221..2738
                     /locus_tag="IEY56_RS16720"
                     /old_locus_tag="GCM10012287_34100"
     CDS             1221..2738
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009187946.1"
                     /locus_tag="IEY56_RS16720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_34100"
                     /product="aldehyde dehydrogenase (NADP(+))"
                     /protein_id="WP_189038071.1"
                     /sec_met_domain="Aldedh (E-value: 5.6e-46, bitscore: 150.9,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWSVDPRTGQQREQVGTEATAVDVDAAVRAAHGALEPLADRAVRA
                     ALLRAAADQLGAASEEIIATADAETALGRPRLPGELARTQAQLRSFADEIEDGTYLGIT
                     VNHADPDSTPPCPDLRRYRIPLGVVAVYAASNFPLAFSVPGGDTASALAAGCPVVVKAH
                     PDHPATSELTAAALRRAAAEVGLPEDVLTVVHGFEAGVELIKHPLVAAAGFTGSVRGGR
                     ALFDAAAARPAPIPFHGELGSLNPVVVTAAAAAERAEEIGAGLAGSMTMGTGQFCTKPG
                     FVLAPEGEDGDKLLSALREKVAEAAQGPLLDSRMRESFLEGISARTELEGVEAPVLAGA
                     GDDGHTVGAGVLTVPAGKVGQPQYELLLEECFGPVTVVARYRDDDEVSAVLSRLPGNLT
                     ATVQLSGGEAAGDGGRGARLLAALTPLAGRVLVNGWPTGVAVAPAQHHGGPYPATTSTS
                     TSVGATAIERWLRPVAYQDAPDALLPAELRESNPLGLPRRVDGRWER"
     gene            complement(2888..3733)
                     /locus_tag="IEY56_RS16725"
                     /old_locus_tag="GCM10012287_34110"
     CDS             complement(2888..3733)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090397.1"
                     /locus_tag="IEY56_RS16725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_34110"
                     /product="DUF1989 domain-containing protein"
                     /protein_id="WP_189037987.1"
                     /transl_table=11
                     /translation="MAGTAAAYRASEGGPLDVDRAFYGRAASALDGRELVERFTVPIRS
                     GRAWEVPAGHVCRLVTVDGPQVGDLNVWNSHDPRERLWASRTRQLQRAHVSTYDRLWST
                     LPFLRPLLTITSDTLAGYGRDAEGGRVHDLLGTRCDPYVNRMLTGEDFDFHCHSNLVRA
                     VLPYGLTEFDVHDVLNVFQCTGLNDDDQYFMKDCPARPGDHLEFFAELDLLCALSTCPG
                     GDLSVPMWGPGSDVDPVEFCHPIGVEVYRLDPELLKGWTPPERAAYRNVHGMSRPEWRP
                     "
     gene            complement(4008..4907)
                     /gene="thpD"
                     /locus_tag="IEY56_RS16730"
                     /old_locus_tag="GCM10012287_34120"
     CDS             complement(4008..4907)
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358305.1"
                     /locus_tag="IEY56_RS16730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_34120"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_189037988.1"
                     /sec_met_domain="PhyH (E-value: 2.9e-39, bitscore: 129.5,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPERTADLYPTRGTTEVATPRMDPVVWSEPGAPGPIEAAVLA
                     DYERDGFLSVDQLITPDEVDMYRQELNRLTTDADVRADERSIIEPKTDEIRTVFEVHKI
                     SELFADLVKDPRVVGRARQILGSDVYVHQSRINVKPGFGATGFYWHSDFETWHAEDGIP
                     NMRTVSVSIALTRNYDTNGGLMIMPGSHNTFLGCAGETPKDNYKKSLQMQNAGTPSDES
                     LTKFADAHGIKLFTGEPGSAVWFDCNCMHGSGDNITPYPRSNVFIVFNSVENEAVEPFA
                     APVRRPDFIGAREFTPVR"
     gene            complement(5001..5405)
                     /locus_tag="IEY56_RS16735"
                     /old_locus_tag="GCM10012287_34130"
     CDS             complement(5001..5405)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907220.1"
                     /locus_tag="IEY56_RS16735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_34130"
                     /product="ectoine synthase"
                     /protein_id="WP_045864309.1"
                     /sec_met_domain="ectoine_synt (E-value: 6.9e-55, bitscore:
                     178.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSIKDIEGTDRHIKSASGTWESKRIVLAKERVGFSLHETTLY
                     AGTETSMWYANHIEAVLCVEGEAELTNDETGEKHLITPGTMYLLDGHEKHTMRPKTDFR
                     CICVFNPPVTGREDHDENGVYPLLTEPAED"
     gene            complement(5482..6750)
                     /gene="ectB"
                     /locus_tag="IEY56_RS16740"
                     /old_locus_tag="GCM10012287_34140"
     CDS             complement(5482..6750)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (29-365). E-value: 2.2e-75.
                     Score: 245.7. Matches aSDomain:
                     nrpspksdomains_IEY56_RS16740_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="IEY56_RS16740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_34140"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_189037989.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.5e-78, bitscore:
                     258.1, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7.2e-06, bitscore:
                     19.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRSWPTIFDRAQGSHMYDEDGHTY
                     LDFFAGAGTLNYGHNNPVLKRALIDYIERDGVVHGLDMSTTAKRAFLETFHEKILKPRD
                     MNHKVMFPGPTGTNAVEAALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDDYLGGTTEDFVWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARA
                     EWLRDLADLCERHDMLLIVDDIQMGCGRTGAFFSFEEAGIKPDIITLSKSIGGYGLPLA
                     LTLFKPELDIWEPGEHNGTFRGNNPAFVTATAAVETYWTDSQMEKQTLSRGEQVETVLR
                     AISEEHTEDVADYRGRGLVWGLEFHDKDRAGAVAKRCFDLGLLVETSGPQSEVVKLLPS
                     LTITPEELDEGLRVLARAVRETA"
     aSDomain        complement(5656..6663)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY56_RS16740_Aminotran_3.1"
                     /evalue="2.20E-75"
                     /label="IEY56_RS16740_Aminotran_3.1"
                     /locus_tag="IEY56_RS16740"
                     /protein_end="365"
                     /protein_start="29"
                     /score="245.7"
                     /tool="antismash"
                     /translation="DRAQGSHMYDEDGHTYLDFFAGAGTLNYGHNNPVLKRALIDYIER
                     DGVVHGLDMSTTAKRAFLETFHEKILKPRDMNHKVMFPGPTGTNAVEAALKLARKVKGR
                     ESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDDYLGGTTEDFVWFERL
                     LEDQGSGLNKPAAVIVETVQGEGGINVARAEWLRDLADLCERHDMLLIVDDIQMGCGRT
                     GAFFSFEEAGIKPDIITLSKSIGGYGLPLALTLFKPELDIWEPGEHNGTFRGNNPAFVT
                     ATAAVETYWTDSQMEKQTLSRGEQVETVLRAISEEHTEDVADYRGRGLVWGLEFH"
     gene            complement(6881..7408)
                     /gene="ectA"
                     /locus_tag="IEY56_RS16745"
                     /old_locus_tag="GCM10012287_34150"
     CDS             complement(6881..7408)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536877.1"
                     /locus_tag="IEY56_RS16745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_34150"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_229711948.1"
                     /transl_table=11
                     /translation="MPEGLTLDAPRPEDGAALWRITRDSRTLDLNSSYSYLLWCRDFAG
                     TSVVARGTDGEPVGFITGYVRPRQPRTLLVWQVAVDEAARGRGLAAAMLDGLAARVARE
                     AGIDGIETTVTPDNTPSNRLFTSFAARHGAPVEKEVLFDAGDFPESGHEPEVLYRIGPV
                     ASLSGLGPLTPR"
     misc_feature    7406..7420
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.16"
                     /tool="antismash"
     misc_feature    complement(7460..7476)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    complement(7616..7631)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    7662..7680
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.79"
                     /tool="antismash"
     gene            7896..8987
                     /locus_tag="IEY56_RS16750"
                     /old_locus_tag="GCM10012287_34160"
     CDS             7896..8987
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141820.1"
                     /locus_tag="IEY56_RS16750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_34160"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_189037991.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.6e-16, bitscore:
                     54.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDGGILHIKGRVLAGPEDVRDELWVVDGHITYERPPGTVPDAGV
                     IEGWVLPGLVDAHCHVGLGSDGPVDESATEKQAVTEREAGALLLRDAGSPSDTRWVDDR
                     ADLPRIIRAGRHIARTKRYIRNFAHEIEPGDLAAYTRREARRGDGWVKLVGDWIDREEG
                     DLAPCWPRWAVEEAIAAAHEEGARVTAHCFAESSLRDLVEAGIDCVEHATGLTEETVPL
                     FAERGVAIVPTLVNTATFPQLAAGGEKYPRWAAHMRRLHERRYETVRAAYEAGIPVFTG
                     TDAGGSLPHGLVSAEVGELVKAGIPAADALSAAVWGARRWLGRPGLEEGAPADLVVYAE
                     DPRADVGVLGSPRRVVLRGEVVH"
     misc_feature    7911..7924
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.27"
                     /tool="antismash"
     misc_feature    complement(9834..9848)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.89"
                     /tool="antismash"
ORIGIN
        1 ggacgacgac gcaggagtcc agcagcacgc ccagcgcgtt cgccgcggcg agcagcccgc
       61 cgccttcgcg cagcgggctc ccctccggga tcccgatgtg gctgccggac acccaggcgg
      121 tcttgagcgc gagatagggc aggcacgcgg cccatgcggc caggcacaga acggtgcgcg
      181 cgcttcgcgg agtcggggtc ttcatgcggt ccaccctcgc ggcgcgcggg ggtgggggcg
      241 tcctgcctga cggcgaaccg cctccgccgc gcggcggaga ccctctcgtc ccggctgcgg
      301 agccgggagg cgcgtcagag gcgcctggtg gccatcgtca gccggtcccg cgcgtcgaac
      361 agtgcgtccc tgatcatctg ctcgtgcgcg ggcgtcagcc gcgcgacggg gaccgagcag
      421 ctgacggcgt cccgcgcggg cgtccggtag gggatggcga cgccgaagca gcgcagcccc
      481 agcgtgttct cctctcggtc gacggcgtag ccctgctcgc gcaccagcgc tagctgccgg
      541 atcagcgcct cgcggtcggt gacggtgtgc tccgtgaggg ccggcagctt ctccggcagc
      601 atctcgcgga cctgctcgtc gtcgtacgtg gccagcagcg ccttgccgag cgacgtggag
      661 tgcgccggca gccgccgccc gacgcgggtg aagggccgca ggtagtgctg cgactggcgc
      721 gtggcgaggt agacgacgtt cgtgccgtcg agcctggcga ggtggatggt ctcggtggtg
      781 tcctcggaga gccggtccag cgtcgggcgg gcggcggcca cggcctcgtc gccgtcgatg
      841 taggaggttc cgaccagcag cgcccgcacg ccgatgccgt agcgtgtgcc cgtggagtcc
      901 gtctccaccc agcccagatc gacgagcgtg cgaagaagca tgtacagact ggacttgggg
      961 tacccgacgg cttcctgcac gctggcgagg gagtgcatgc cgggccgtcc ggcgaagaac
     1021 tccagcagct ccaccgtgcg gacagcggac ttgacctgcg acgcacccgt ctcaccggct
     1081 gacatcgacc ttgaccccct cgtcgcggca ctcttagggt ccccggcagt ggttcactga
     1141 cagagacggt gttcagcata tcgaacaacc tctctgcgga gacaagcacg cggcaggagg
     1201 aaatcacggt ggcagcacca gtgtggagcg tcgaccccag gaccggacag cagcgcgagc
     1261 aggtcggcac ggaggccaca gccgtcgacg tcgacgcggc ggtacgcgcc gcgcacggcg
     1321 ccctcgagcc gctcgccgac cgcgcggtgc gcgccgcgct gctccgcgcc gcggcagatc
     1381 aactgggcgc ggcgagcgag gagatcatcg cgacggcgga cgccgagacc gccctcgggc
     1441 ggccgcggct ccccggcgag ctggcccgca cccaggccca gctgcgctcc ttcgccgacg
     1501 agatcgagga cggcacctac ctcggcatca ccgtcaacca cgccgacccc gactcgaccc
     1561 cgccctgccc cgacctgcgc cgctaccgga tcccgctcgg cgtcgtggcg gtctacgccg
     1621 cctccaactt cccgctggcc ttctccgtgc ccggcggcga caccgccagc gcgctcgccg
     1681 cgggctgccc cgtcgtcgtc aaggcccacc cggaccaccc ggcgacgtcc gagctgacgg
     1741 cggcggcgct gcgccgcgcg gcggccgagg tggggctgcc cgaggacgta ctcaccgtgg
     1801 tgcacgggtt cgaggcgggc gtggagctca tcaagcaccc cctcgtcgcg gcggcggggt
     1861 tcaccgggtc cgtccgcggc ggccgcgccc tcttcgacgc cgctgcggcc aggccggcgc
     1921 ccatcccctt ccacggcgaa ctcggctccc tcaaccccgt ggtggtcacg gccgccgcgg
     1981 ctgccgagcg ggcggaggag atcggtgcgg ggctcgccgg ttccatgacg atgggcaccg
     2041 gccagttctg cacgaagccc ggattcgtcc tcgcacctga gggtgaggac ggcgacaaac
     2101 tgctctccgc cctgcgggag aaggtcgccg aggcggccca agggcccttg ctggacagcc
     2161 ggatgcgcga gtccttcctg gaaggcatca gcgcccgcac ggagttggag ggcgtcgagg
     2221 ctcccgtgct cgcgggcgcg ggcgacgacg ggcacaccgt cggtgccggc gtcctcaccg
     2281 ttcccgccgg gaaggtcggg cagccgcagt acgagttgct gctggaggag tgcttcggcc
     2341 cggtcaccgt cgtcgcgcgc taccgggacg acgacgaggt ctccgcggtg ctctcgcggc
     2401 tccccggcaa cctgaccgcc accgtccagc tcagcggagg cgaagccgcc ggtgacggcg
     2461 gccgcggtgc gcgcctgctg gcggcgctga ccccgctggc gggccgcgtc ctcgtcaacg
     2521 gctggcccac gggcgtcgcc gtggcgcccg cacagcacca cggcggcccc tacccggcca
     2581 ccacctccac ctcgacctcc gtgggcgcca ccgcgatcga gcgctggctc cgtcccgtcg
     2641 cctaccagga cgcgccggac gcgctgctgc cggccgagct gcgggagtcc aacccgctgg
     2701 ggctgccgcg gcgcgtcgac gggcgctggg agcgctgaga ggcgcggtca gcgcgcccct
     2761 agcgcggccg gaaccggaag ggcccgaggc ccaggacagg cggcatcccg cggcgtcccg
     2821 cgggatgccg ccgcgcgttg cgtaacggga ccgtgctcgg cgcgtccggc ggccggagag
     2881 gggcggttca gggccgccac tcgggacggc tcatgccgtg cacgttgcgg taggcggccc
     2941 gttccggggg cgtccagccc ttcagcagct ccggatcgag gcggtagacc tcgacgccga
     3001 tcggatggca gaactcgacg gggtcgacgt cggagcccgg cccccacatg ggaaccgaca
     3061 gatcgccgcc cgggcacgtc gagagcgcgc acagcaggtc gagttcggcg aagaactcca
     3121 ggtggtcgcc ggggcgcgcg gggcagtcct tcatgaagta ctggtcgtcg tcgttgagtc
     3181 cggtgcactg gaagacgttg aggacgtcgt gcacgtcgaa ctccgtgagc ccgtacggga
     3241 gtacggcgcg gaccaggttc gagtggcagt ggaagtcgaa gtcctcgccg gtcagcatgc
     3301 ggttgacgta cgggtcgcag cgcgtgccca gcaggtcgtg gaccctgccg ccctccgcgt
     3361 ccctcccgta cccggcgagg gtgtcggagg tgatcgtcag cagcggtcgc aggaacggca
     3421 gcgtcgacca caaccggtcg taggtgctca cgtgcgcccg ctgcagctgc ctcgtgcgcg
     3481 aggcccacag ccgctcgcgg gggtcgtgac tgttccatac gttgaggtcg ccgacctggg
     3541 ggccgtccac cgtgaccagg cggcacacgt gccccgcggg gacctcccag gccctgccgg
     3601 agcggatcgg cacggtgaag cgctccacga gctcccgtcc gtccagcgcg gaggccgcgc
     3661 gtccgtagaa cgcgcggtcg acgtcgaggg ggccgccctc ggatgcccgg tatgcggctg
     3721 cggtgcctgc catgcgtgcg tacgctccct cgctgtcgtg ccgtcgtgcc gtcgtgctgt
     3781 acgtggtgct gtggcgccgt cgtgctgtcc gagccgccgc cccggcagac ggcgacgcac
     3841 gcctctcctc cgtcggactg ggctggcggg ctggcgggcg gcggacccgg ccggtgccgg
     3901 tggtgcggct ccgccgatct caacggagag gcgcccgcgc ggaaaagggg gaggccgtca
     3961 tgcggcctcc cccttctcca gcgggatcag gtgtgacgtc gtgtgtgtca cctgacgggc
     4021 gtgaactccc gtgccccgat gaagtcggga cggcgtaccg gtgccgcgaa gggctccacc
     4081 gcctcgttct ccacgctgtt gaagacgatg aacacgttgc tccgggggta cggagtgatg
     4141 ttgtcaccgc ttccgtgcat gcagttgcag tcgaaccaga ccgccgaacc cggctcgccc
     4201 gtgaagagct tgatgccgtg tgcgtcggcg aacttggtca gggactcgtc ggagggagtc
     4261 cccgcgttct gcatctgcag tgatttcttg tagttgtcct tcggcgtctc gcccgcgcag
     4321 ccgaggaacg tgttgtgcga ccccggcatg atcatcaagc cgccgttggt gtcgtagttg
     4381 cgggtcagcg cgatcgagac cgagacggtc cgcatgttgg ggatgccgtc ttccgcgtgc
     4441 caggtctcga agtcggagtg ccagtagaag cccgtggccc cgaagcccgg cttgacgttg
     4501 atccgggact ggtggacgta gacgtccgat cccaggatct gccgtgcccg gcccactacc
     4561 cgcgggtcct tcaccaggtc ggcgaagagc tcgctgatct tgtgcacctc gaacacggtg
     4621 cggatctcgt ccgtcttggg ctcgatgatc gagcgctcgt cggcacggac atccgcatcc
     4681 gtggtgagcc ggttcagttc ctgccggtac atgtcgacct catcgggagt gatgagctgg
     4741 tcgaccgaaa ggaatccgtc ccgctcgtag tccgccagca ccgcggcctc gatgggcccc
     4801 ggggcacccg gctcggacca cacgactggg tccatgcgtg gtgtggccac ctcggtggtt
     4861 ccgcgagtcg ggtacaggtc ggcggttcgc tcgggtgcgg tggtcatggt gttgccttcc
     4921 tctcctctcg tacggccctg tattggtggg cgagcggcct gatgcggccg aaacggcctg
     4981 tggcggccgg gctttggaac tcagtcctcg gcgggttcgg tgagaagcgg gtagacgccg
     5041 ttctcgtcgt gatcctcccg gccggtgacg ggcgggttga agacacagat gcaccggaag
     5101 tcggtcttgg ggcgcatggt gtgcttctcg tgcccgtcga ggaggtacat ggtgccgggg
     5161 gtgatcaggt gcttctcacc cgtctcgtcg ttggtgagtt ccgcctcgcc ctcgacgcag
     5221 agtacggctt cgatgtgatt tgcgtaccac atcgacgtct ccgtacccgc gtagagcgtg
     5281 gtctcgtgca gggagaagcc gactcgctcc ttggccagca cgatccgctt gctctcccag
     5341 gtaccggatg cggacttgat gtgtcggtcg gtgccttcga tgtccttgat ggaacgaaca
     5401 atcacgttct gtcttgccct tctctctcat tacggggtcg gcccgccccg gacgcaaccg
     5461 gggcgggccg tgaacgggaa gttacgcggt ttcgcggact gcgcgcgcca gtacgcgcag
     5521 cccctcgtcc agctcctcgg gagtgatcgt cagggacggc aggagcttga ccacctcgct
     5581 ctgcggaccc gaggtctcga cgagcagacc caggtcgaag cagcgcttgg cgacggcacc
     5641 ggcacggtcc ttgtcgtgga actccaggcc ccacacgagg ccgcggccgc ggtagtcggc
     5701 cacgtcttcg gtgtgttcct cggaaatcgc gcgcaaaacc gtctcaacct gctcaccgcg
     5761 ggagagggtc tgcttctcca tctggctgtc ggtccagtag gtctccaccg cggccgtggc
     5821 cgtcacgaag gccgggttgt tgccgcggaa ggtgccgttg tgctcgccgg gctcccagat
     5881 gtccagctcg ggcttgaaca gggtgagcgc cagcggcagt ccgtagccgc cgatggactt
     5941 cgacagggtg atgatgtccg gcttgatgcc cgcctcctcg aaggagaaga aggcgccggt
     6001 gcggccgcag cccatctgga tgtcgtcgac gatgagcagc atgtcgtgcc gctcgcacag
     6061 gtcggccagg tcgcgcagcc actcggcgcg cgcgacgttg atgccgccct cgccctggac
     6121 cgtttcgacg atcaccgcgg cgggcttgtt gaggccggaa ccctggtcct ccagcagccg
     6181 ctcgaaccag acgaagtcct cggtcgtgcc gccgaggtag tcgtcgaacg gcatgggcgt
     6241 gccgtggacg agcgggatgc ccgcgccggc gcgcttgaag gcgttgccgg tgacggcgag
     6301 cgagcccagc gacatgccgt ggaaggcgtt ggtgaaggag acgatcgact cgcggccctt
     6361 taccttgcgg gcgagcttca gcgccgcctc gacggcgttg gtgccggtcg ggccggggaa
     6421 catcaccttg tggttcatgt cgcggggctt gaggatcttc tcgtggaagg tctccaggaa
     6481 ggcccgcttg gcggtcgtgc tcatgtccaa cccgtgcacg acgccgtcac gttcgatgta
     6541 gtcgatcagc gcccgtttga gaacggggtt gttgtggccg tagttgagcg ttcccgcacc
     6601 ggcgaagaag tccaggtagg tgtggccgtc ttcgtcgtac atgtgcgagc cctgggcccg
     6661 gtcgaagatc gtgggccagc tgcggcagta gctgcggact tccgactcga cggtctcgaa
     6721 gacgctgagg tccggctggg tgatggtcac agcatgctcc tgggagtgag ttgagtgctg
     6781 agaagtgctt cttgcggatg tgccttgcga agttgcgaag ttcaggggtt gcggatctgt
     6841 tcgaagttcg ggacgcgaag cagtacgcgc gggcgggcgc tcagcgtggg gtgagcggcc
     6901 cgaggccgga cagcgacgcg accggcccga tgcggtacag cacttcgggt tcgtgaccgc
     6961 tctcggggaa gtcgcccgcg tcgaagagca cctccttctc cacgggggcg ccgtggcgcg
     7021 ccgcgaaaga ggtgaagagg cggttcgagg gcgtgttgtc cggggtgacg gtggtctcga
     7081 tcccgtcgat ccccgcttcc cgcgcgacgc gggcggcgag cccgtcgagc atcgccgccg
     7141 ccagcccgcg gcctcgtgcc gcctcgtcga cggcgacctg ccagacgagg agcgtccggg
     7201 gctgccgggg gcgcacgtag ccggtgatga agccgactgg ttcgccgtcc gtgccccgtg
     7261 ctaccacgga ggtccctgcg aagtcgcggc accacaggag atagctgtag gaggagttga
     7321 ggtcgagcgt ccgtgagtcg cgggtgatgc gccacagcgc cgccccgtcc tcaggccgcg
     7381 gagcgtcgag tgtcagcccc tccggcattt ccaggaaatt cctatgggca cgtgcatggt
     7441 ctgcttgtgc ggcggtcatg ggtattaaat ttacccagca gatgccaaaa acgcacggcg
     7501 gaccggggtt acgcaagaag gggttcctgt gttatcgcgc gcaggcgcgc aggtgagatg
     7561 aggggcgccg ttatgccccg acttaaaggg attttcccgg aggatacggg cgccctgtgg
     7621 agtctgtcac atcctcgaaa cgacctcgtg aggtgctcga attacgtcag ggtaaccata
     7681 gaaaattcga gtgtttaagc cctcggaaag cgggaacaag aatacgggcg gctacgctcg
     7741 atgaattccg ggaatgcatt ctcctccgtt gagttcaatg tcgcatctcc aagcccgcga
     7801 gcgcaatggg atcgccacgt tccgtatgcg gtcctgagca gccggaaatg ccgggcgggt
     7861 atgaacgcgg gggagcggct cgtaggctgc ggcccatgag cgacggcggg attcttcaca
     7921 tcaaggggcg cgtgctggcc gggcccgagg acgtccggga cgagctgtgg gtggtggacg
     7981 ggcacatcac ctacgaacgc cccccgggca cggttcctga cgccggcgtc atcgagggct
     8041 gggtgctgcc cggcctcgtg gacgcccact gccacgtggg gctcggctcc gacggccccg
     8101 tcgacgagtc ggccacggag aagcaggcgg tcacggagcg ggaggccggc gcgctgctgc
     8161 tgcgcgacgc gggctccccc tcggacaccc gctgggtcga cgaccgcgcg gatctgccgc
     8221 ggatcatccg cgccggcagg cacatcgccc gcacgaagcg ctacatccgc aacttcgcgc
     8281 acgagatcga acccggcgac ctcgccgcct acacccggcg cgaggcccgc cgcggcgacg
     8341 gctgggtgaa gctcgtcggg gactggatcg accgcgagga gggcgacctc gccccgtgct
     8401 ggccgcgctg ggccgtggag gaggcgatcg ccgccgccca cgaggagggc gcccgcgtca
     8461 ctgcgcactg cttcgcggag agctcgctcc gcgacctggt cgaggccggg atcgactgcg
     8521 tcgaacacgc tacggggctc acggaggaga ccgtcccgct cttcgcggag cgcggcgtcg
     8581 cgatcgtccc caccctcgtg aacaccgcca cgttcccgca gctcgccgcg ggaggcgaga
     8641 agtacccccg ctgggccgcg cacatgcggc ggctccacga gcgccgctac gagacggtcc
     8701 gcgccgcgta cgaggcgggc atccccgtct tcacggggac ggacgccggc gggtcgctgc
     8761 cgcacgggct cgtctccgcg gaggtcggcg agctggtcaa ggcgggcatc cccgcggcgg
     8821 acgccctgtc ggcggccgtc tggggcgccc ggcgctggct gggccgcccc ggactggagg
     8881 agggagcccc cgccgacctc gtcgtgtacg cggaggaccc gcgggcggac gtcggggtgc
     8941 tgggctcccc gcggagggtc gtgctgcggg gagaggtggt gcactagccg tggaggacgg
     9001 cggagcgctc acggcccggg agggcggaca aggcgcgggg gaggccccgc agcggatgcc
     9061 ggaggggtcc cgccgggtgg acgcctccgg gatcgtctcg tggagcgcca tggagctctc
     9121 gcgggccgtc gcgggccgtg aagtgacgtg caccgaggtc atgcgggcgt acttggagca
     9181 catcgaacgg gtcaatccgc acgtctgcgc gatcgtcggg gcacaggcgc cggaactctc
     9241 cctggagcag gcgcgggagc gggaccggga gctggagcgc ggtgagagcc gcggctggat
     9301 gcacggcttc ccgtacgcgg tgaaggacct cgcggaggcg cgcggtctgc cgtggactga
     9361 gggttcgccc ctgcacaggg accgcgtcgc ggagcgggac gccccgttcg tgcggcgcgt
     9421 cagggacgcc ggcgcggtcg tgatcggcaa gaccaacacc cccgagttcg gcctgggttc
     9481 gcagacgtac aaccaggtgt gggggacgac gggcaacgcc tacgaccccg cgctcacggc
     9541 gggcggcagc agcgggggag cggcctgcgc cctcgccctg cggatgctgc cggtcgccga
     9601 cggcagcgac tacatgggtt ccctgcgcaa ccccgccgcg ttcaacaacg tgctgggcct
     9661 gcgcccgagt cagggacgcg tcccaggccc cgggttcacc ggccagccgg gtgtcgcggg
     9721 tccgatggcc cgcacggtga cggacctcgc gtggctgctg tcggtgatgg cgggaccgca
     9781 cgaggagtcc ccgacggcgt tcccggagag cggcgaacgc ttccgggagc ccctggaacg
     9841 cgatttccgt gggacgcgcg tggcatgggt cggcgactgg cgtgggcggc tggccaccga
     9901 gccgggagtg ctggaggtgt gccgttccgc gctgtccgtc ttcgaggcgc tcggatgcga
     9961 agtgaccgac gccgtaccgg acttcccggc cgacgagctc tggcggacgt tcctcacgtg
    10021 gcgctggtgg gcggccctgg accggtacgg cctctacgcc gatcccgccg cacgggagcg
    10081 gatgaagccc gaggcggtgt gggagacgga gcggggtctg gccctgagcg ccctcgacgt
    10141 cgcggaggcg gccgcgtcgc gggaccgttg gtacgcggcg ctggcggagt tcttccgcga
    10201 ctacgactac gtcctcgcac cagcggcaca ggtcttcccc ttcgcgaagg agacgaggtg
    10261 gcccgaggtg gtcggcggac gccgtatgga cacctaccac cgctggatgg agacggtggt
    10321 gccctggtcg ctggtcggcg tgccggtgat cgggatgccg gccgggttcg gccggcaggg
    10381 gctgccggcg ggcctgcagc tcgtc
//
