LOCUS       NZ_BMMP01000004        10213 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces daqingensis strain CGMCC 4.7178 sequence04, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMP01000004
VERSION     NZ_BMMP01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces daqingensis
  ORGANISM  Streptomyces daqingensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 358039)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 66X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645895.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:14:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,667
            CDSs (total)                      :: 5,602
            Genes (coding)                    :: 5,509
            CDSs (with protein)               :: 5,509
            Genes (RNA)                       :: 65
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 93
            CDSs (without protein)            :: 93
            Pseudo Genes (ambiguous residues) :: 0 of 93
            Pseudo Genes (frameshifted)       :: 35 of 93
            Pseudo Genes (incomplete)         :: 69 of 93
            Pseudo Genes (internal stop)      :: 2 of 93
            Pseudo Genes (multiple problems)  :: 13 of 93
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:17:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 32200
            Orig. end                         :: 42413
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMP01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10213
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10213
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10213
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5213](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5213
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    422..436
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            730..1149
                     /locus_tag="IEY56_RS07265"
                     /old_locus_tag="GCM10012287_14860"
     CDS             730..1149
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077214.1"
                     /locus_tag="IEY56_RS07265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_14860"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_189036286.1"
                     /transl_table=11
                     /translation="MTTARDVMSPGAEYVKTDQTAADAARIMTRTGLGALPICGKDDKL
                     KGVVTDRDIVVKVLGQGRDPGAFPAGDLNQREAVTIGADDTTDEVLATMSRHKVRRLPV
                     IDGNRLVGMVAVADVARTLPNATTGELVEALSADY"
     gene            1306..1539
                     /locus_tag="IEY56_RS07270"
                     /old_locus_tag="GCM10012287_14870"
     CDS             1306..1539
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718952.1"
                     /locus_tag="IEY56_RS07270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_14870"
                     /product="hypothetical protein"
                     /protein_id="WP_189036287.1"
                     /transl_table=11
                     /translation="MAVCEVCGNDYAETFEVRAAGAVHVFDSIECAAQKMAPICENCGC
                     RILGHGLQAEGRYYCCASCARMQGRMELADSV"
     gene            complement(1603..2916)
                     /locus_tag="IEY56_RS07275"
                     /old_locus_tag="GCM10012287_14880"
     CDS             complement(1603..2916)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="IEY56_RS07275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_14880"
                     /product="MFS transporter"
                     /protein_id="WP_189036288.1"
                     /transl_table=11
                     /translation="MPQKTTSPYDPGVRRAVVEAPGAPVTKGWTARYALASTGMWLAFL
                     TPAQVQIARQAEVFSPDGKEALLGLATGVGAAVTAVAVPAFGAVSDRTRSRFGRRRPWV
                     ALGSLLAAVGILLLATATGAVAMVFGWAVAQLGLSAVQAGLVAAIPDRVPKPQLGTVAG
                     WAGMTQMLGALLGTVLVNQLVTGLVAGYAACAVVAVVSVVPFLAGHREQDTRGAEPGPV
                     SPATSAPPAGGPVSGPRKSGRPLLSRLASVPRDLLWTWVSRFLVVLAFALITQYLLYYL
                     TDALRVDEPQEAVLTVTAATVLCAMAAALIAGRWSDRTGRRRVFVAAGGAAMGLGALGL
                     ALLPSWPVTVGAAVAVGTGFGTFLAVDLAVIASVLPSAADTGRDLGIFAIATATPQVLA
                     PVLAVPVLAVAGYGGLYVLTAVVSVAGGAAVLLVRSVR"
     misc_feature    complement(2958..2972)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.18"
                     /tool="antismash"
     gene            complement(3341..3817)
                     /locus_tag="IEY56_RS07280"
                     /old_locus_tag="GCM10012287_14890"
     CDS             complement(3341..3817)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010057007.1"
                     /locus_tag="IEY56_RS07280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_14890"
                     /product="phospholipase"
                     /protein_id="WP_189036289.1"
                     /transl_table=11
                     /translation="MRRRLTSGLVVSSAALLAVMGSATTAVADPADKPQVLSSWTQTSA
                     SSQNAFLAARSNQGNWAAYNFDWSTDVCSSSPDNPFGFPFENGCIRHDFGYRNYKAQGT
                     FEANKARVDSAFYEDLKRVCNGYSGATKASCDALAWTYYQAVKVLGFEKASPVG"
     gene            5001..5213
                     /locus_tag="IEY56_RS07285"
                     /old_locus_tag="GCM10012287_14900"
     CDS             5001..5213
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="IEY56_RS07285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_14900"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_189036290.1"
                     /sec_met_domain="strepbact (E-value: 1.4e-25, bitscore:
                     84.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTPQVETREISDNDLDNVSGGVLGAVVGTAVSTADSVAPVSET
                     VATVNGTVSGAVGIDTSQVTGLAGL"
     misc_feature    complement(5488..5508)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.22"
                     /tool="antismash"
     gene            5572..6378
                     /locus_tag="IEY56_RS07290"
                     /old_locus_tag="GCM10012287_14910"
     CDS             5572..6378
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="IEY56_RS07290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_14910"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_189036291.1"
                     /transl_table=11
                     /translation="MQFRQKAFSKLQSPEELDLPVRFARPQGWLVLLVTVLVMAGAGYW
                     AVTGKVSGKLHAPGILTHPQGSYVLQSPVSGQVTQVLAEEGTMLRAGAPVLKVRTERGY
                     RAVRTVAAGKMTTLTAKIGTVVTTGKDVATVERIESTDEPLVAMVYVPGHNGASVRVNS
                     QVDLTVQSAPTEKYGVLRGRVKAVGRAPQTRQQLTGFLGNAQLAEEFSKEGQPVAVMVQ
                     LERASGTESGYRWSSDEGPPYALDSMTMADAAVHQPAQRPVDWLLP"
     misc_feature    complement(5586..5597)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.66"
                     /tool="antismash"
     gene            6558..8675
                     /locus_tag="IEY56_RS07295"
                     /old_locus_tag="GCM10012287_14920"
     CDS             6558..8675
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944281.1"
                     /locus_tag="IEY56_RS07295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10012287_14920"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_229711719.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.6e-37, bitscore:
                     120.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAVECGAAALSMVLGHYGRHVPLEELRIACGVSRDGSRASNLLK
                     AARSYGLQAKGMQMEPAALAAVAAPAVLFWEFNHYVVYDGMGRRFGRRGVFINDPDKGR
                     RFVPLEEFDTSFTGVVLTFEPGDDFHPGGRRPGFLSAMPARLRGTTGTMLAALLASLLL
                     VAVGAAVPALSRTYIDMFLIGNETSLLSVLFASMGAMVLLTAVLTGLQQANLLRGRIIS
                     STLSSARFFRHLLRLPVTFFAQRSPADLVQRLQSNDTVAETLARDLAAAGVDAVVVVLY
                     AVLLWTYDPQLTLIGVLIALLNLVAMRVVIRLRATGTQKLRADTARLTNTSYTGLQLIE
                     TMKATGGENGYFRRWAGQHATTLEEQQKLGVPSAALAVVAPTLATLNSAMILLIGGMRA
                     VEGHISIGLLVAFQALVTRFTAPITRLNGVAGRIQDFAADVARLKDVENFPVDSLYSRR
                     APAASTRRLKGHVSLENITFGYSPLDKPLLTEFSLSVGPGRQVALVGGSGSGKSTVSRL
                     ISGLYSPWEGVIRIDGQRLEDIPRSSLAASVSFVDQDVFLFEGTVRDNVALWDPSIPDE
                     AVTAALQDAAVYEDFARRPGGIRCRVEQDGRNLSGGQRQRLEIARALVRRPSILVLDEV
                     TSALDARTEQVIIDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGTVVERGRHEELVAA
                     GGQYAELVKEH"
     misc_feature    complement(9617..9631)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.86"
                     /tool="antismash"
ORIGIN
        1 cggcgtcgtg acgtacggcg agggcttcac cgtgcagccc ttcaccaaca tgatgacgac
       61 gatcgacctc accggcgagc agctgatcac tgctctccag cagcaggtca gcggggacaa
      121 cgaggcggag cccaagatcc tccagccgtc cgagggcttc acctacaccc tcgacatgac
      181 gaagtccggc aaggaccgca tcgtcacgga ctcggtgaag ctggacggca aggccatcga
      241 ggcgggcgag acgtaccacg tcgcgatgaa cgagttcctc gcgggcggcg gcgacggctt
      301 cccggtcttc aaggaggcca aggacaagct cgtcggcgcc tccgacctgg aggcgctgga
      361 gggctacttc gcggagcact cctcggagtc cggcccgctg gccccgccga aggcggaccg
      421 catcaagatc gtcgagtgac gatcggcccc tgaccggagg ggcgcgagcg cgtccctccg
      481 gcccggccgc gtatgacggt gccctgctcc gtggaagacc acggaacagg gcaccgtcgc
      541 gtgtgcggga cggtgcggct cccgtcgcgc ggggggtcag gggccgtgcg cggggtcagg
      601 ggccgtgcgc ggggtggtca ggtttgaacg cgaccgccgc gtgctacccg gctccgggcc
      661 gttcgcgctc ctccacggag cgggagcgga cacagcaatg ccgcgaacgt atgccgtcag
      721 gagcgatcca tgactaccgc acgcgatgtg atgagccccg gcgccgagta tgtgaagacg
      781 gatcagaccg ccgccgacgc cgcccgaata atgacgagga ccggcctggg cgccctgccg
      841 atctgcggca aggacgacaa gctcaagggc gtggtcacgg accgggacat cgtcgtgaag
      901 gtgctcggcc agggccgcga ccccggcgcc ttccccgccg gcgacctcaa ccagcgggag
      961 gccgtcacga tcggcgccga cgacaccacc gacgaggttc tcgccaccat gagccgccac
     1021 aaggtgcgcc gtctgcccgt gatcgacggg aaccggctcg tcggcatggt ggccgtcgcg
     1081 gacgtggccc gcacgctgcc gaacgccacc accggcgaac tcgtcgaggc gctgtcggcg
     1141 gactactgac ggcgcggccc cgggcggcgt cccgcccccg gggccgtcag gtgcggtcca
     1201 ccggcagcac ccccaccggc gcaccgcgag agcgccctga agaagagtca gtccgttcca
     1261 cgtcaccacg tcacttcctt tccttcacac caccgaggag ccgagatggc cgtatgtgaa
     1321 gtctgcggaa acgactacgc cgagacgttc gaagtgcgcg cggccggcgc cgtgcacgtc
     1381 ttcgacagca tcgaatgcgc cgcgcagaag atggcgccca tctgcgagaa ctgcgggtgc
     1441 cgcatcctgg ggcacggact gcaggccgag gggcgctact actgctgcgc cagctgtgcc
     1501 cgcatgcagg gccggatgga gctggccgac agcgtctgag gacctcgtgg gccgccgcga
     1561 acgtgcggcg gcccacggag gtctctcccc ggtatgccgg ctctaccgga cggagcgcac
     1621 cagcagcacg gccgcgcctc ccgcgacgct gacgacggcc gtcagcacgt acaggccgcc
     1681 gtagccggcg acggcgagca cgggcaccgc caggacgggc gccaggacct gcggcgtcgc
     1741 cgtggcgatg gcgaagatgc ccaggtcgcg gcccgtgtcg gccgccgagg gcagcacgga
     1801 cgcgatgacg gccaggtcga cggcgaggaa cgtgccgaag cccgtgccta cggcgaccgc
     1861 cgcaccgacg gtgacgggcc agctcggcag cagcgccagc ccgagggcgc ccaggcccat
     1921 cgcggcgccg cccgcggcga cgaacacgcg cctgcggccg gtcctgtcgg accagcggcc
     1981 cgcgatcagc gccgccgcca tggcgcacag caccgtcgcg gcggtgaccg tgagtaccgc
     2041 ctcctggggc tcgtcgaccc gcaacgcgtc cgtcaggtag tacaggaggt actgcgtgat
     2101 cagcgcgaag gccaggacga cgaggaacct gctcacccac gtccacagca ggtcgcgcgg
     2161 cacggaggcc agccgggaga gcagcggccg tccggacttc cgcggcccgc tcaccggacc
     2221 gccggcgggc ggggcggacg tggcggggct gaccggaccg ggctccgctc cgcgggtgtc
     2281 ctgctcgcgg tgcccggcga ggaacggcac gacggagacg acggcgacca cggcgcaggc
     2341 cgcgtacccg gcgacgaggc cggtgacgag ctggttgacg agcaccgtcc ccagcagggc
     2401 ccccagcatc tgcgtcatcc cggcccatcc cgcgaccgtg cccagctgcg gcttcggcac
     2461 ccggtccgga atggcggcga ccagccccgc ctgcacggcg gacagcccga gttgggccac
     2521 cgcccatccg aagaccatcg ccaccgcccc ggtcgcggtg gccagcagca ggatccccac
     2581 cgccgccagc aggctcccca gcgccaccca cggcctgcgg cgcccgaaac gggagcgggt
     2641 cctgtcgctg acggctccga acgcggggac cgccaccgcc gtgaccgccg cacccactcc
     2701 ggtggccagc cccagcaggg cctccttgcc gtcaggcgag aacacctcgg cctgacgggc
     2761 gatctgcacc tgcgccggag tgaggaaggc gagccacatg ccggtgctgg cgagcgcgta
     2821 gcgcgcggtc cagcccttgg tgaccggtgc gccgggcgcc tcgacgacgg ctcgccggac
     2881 acctgggtcg tacgggctcg tcgtcttctg gggcatgtcg ctctccgcgg tgcacgtccg
     2941 gcagggcaag ggctaggggc tgtctgacaa atggcgccgt tcgcccggag ggcggggctc
     3001 gcgtcgtctg gtgcgtgcgg atgcaaggcg gaggtccgtc ctcgtagtgg gctactcggt
     3061 cggtccgaca acgcagcaga cgtgcgtgcc aggcggcgcg agccaggcgc catttgtcag
     3121 acaggccctg gggcggggac agcgtgctgc cccgcccttg cgcgctgctt gcgcggcggt
     3181 cctccgtgct ccggccgccg ggcgaggaca cgctcatgcg ggggccggtc gtgcgaaggt
     3241 gcgggcgcac gacagcgcgg ggcgcccgtc gagggcgccc cgcgctgtca tgcacgcgct
     3301 gcgggcgtgg tcgtacccgg ggaacgggtc cggcgtggga tcagccgacc gggctggcct
     3361 tctcgaagcc cagcaccttc actgcctggt agtaggtcca cgcgagtgcg tcgcaggagg
     3421 ccttcgtggc gccgctgtag ccgttgcaga cgcgcttgag gtcctcgtag aaggcgctgt
     3481 cgacgcgggc cttgttggcc tcgaaggtgc cctgcgcctt gtagttgcgg tagccgaagt
     3541 cgtgccggat gcagccgttc tcgaagggga agccgaacgg gttgtccggt gacgaggagc
     3601 agacgtccgt cgaccagtcg aagttgtagg cggcccagtt cccctggttc gaccgggcgg
     3661 cgaggaatgc gttctggctc gaggcgctgg tctgcgtcca gctggagagg acctgaggct
     3721 tgtccgcggg gtcggcgacg gcggtcgtcg cggagcccat gacggcgagc agcgccgcgg
     3781 atgaaacgac cagacccgaa gtgagtcttc gacgcatttc atacctccgt gggggacgcc
     3841 ggtccggcgg tcggaccggg caatgcatga gcatgacaga acaatcgctt tccaagtagg
     3901 cgcgtgcgcc gacgatttcg agccgaaacc cgaccgcacc gggggctgcg cggccccggc
     3961 cgaccccgat acggcccgag gccccgggaa cggatcccgg ggcctcggtt gccaacgtgg
     4021 gggaagaagc ccacgaccag cctggcactc caataacgaa acggatgacg catcgtcacg
     4081 gtttctcgat atccgcgacg tttgaccgaa aagcagacaa cccgcgcatc tctcctcctt
     4141 caccccggga acgagcaggg cgcactccgg cgcgcacgag cacacacccc ccggcgcaca
     4201 cccaggacct ccgcgcgtcc caccggcccg ccccgtcgcc tcacacaccg cccgacgggc
     4261 cgtcacccct gctccccgct ccgcgagttc ggcccgtccg actcccaccc gccggccgga
     4321 cccggagcga gcacaccctc ccgctccgcg agttgacgta tcgcgggcgc cgtgtaaagc
     4381 ggcgtgcgaa tgcgcgcgcg aattcatccg cctcgtctca ccatttgaac aagccatttc
     4441 gcccttagcg gcccttaggc gtccttatgg aaacgcggac tccggtacgg actcccccgg
     4501 tcacctcctg tcaccgcgac cgaactgccg tctgcacgcg gcgaatcagc aggtcggagc
     4561 gtggtgacgg cgggaagtgc cgtacagcgg agccgatttc agcgaacctg cacaactggt
     4621 ccgtacggga ggcacatgac cccgcgagcc cgtccgtgta cacccggaac ccggccgact
     4681 tggtgcggga atgtccaatt ggcagcgcac gtaaggactt ccgcctccgg cacgcgagga
     4741 gcggcaagtg aagagttcgc cacgaattcg tggacggtac tgcacttgga agaaacaacg
     4801 tgcccggatc tgcgccgaac cggcgcacga acgagtggcc cggcagcgct ggcgcgtgct
     4861 ttgatcggcc cagacgcgga agttgaacga atggttcccg ttgtcgggca tcagacgacc
     4921 gctcgtacgg ccggacggct ttccccgagc cggccgatgc tattgagaga acatccagag
     4981 caagcgaagg gaagctcctc atggacttca cgccccaggt tgagacccgc gagatttccg
     5041 acaacgacct ggacaacgtt tccggtggcg ttctcggcgc ggtcgtcggc accgccgtca
     5101 gcaccgccga ctccgtcgcc ccggtttcgg agaccgtcgc caccgtcaac ggcaccgtct
     5161 ccggcgccgt cggcatcgac acctcccagg tcacgggtct cgccggcctc tgaggcgaac
     5221 cctgccaccg agcgccggag caggccgtgc tgatcggcgc ggaaccctgc gcacccggcg
     5281 aatcggaatc ccagtggggt gaccgtgagc cccggaacca ttccgttccg gggctcacgg
     5341 atgcgtcccg gaccggccgc gccccggcaa taccccgcgt attgccgcgc cttcggcagt
     5401 cgctgtcaat tcttctgtca gccactgccg cgagtggtat cacctctctc tccactcgtc
     5461 tcaccggcgc ccgtccggcc gccctgtcat tcgtcccggc gtcgatatgg agacgccacc
     5521 gaaggaagcg tcgtgcccga aagcaacgaa cgcagttgag ggaatagccc cgtgcagttc
     5581 cggcagaagg cgttttccaa gctgcagtcc cccgaggaac tcgacctgcc cgtgcgcttc
     5641 gcgcggccgc aggggtggct cgtgctgctc gtgaccgtgc tcgtcatggc cggagcgggt
     5701 tactgggccg tcacgggcaa ggtgtccggc aagctgcacg cgcccggcat cctcacccac
     5761 ccacagggca gttacgtcct ccagagcccg gtctccggcc aggtcacgca ggtcctcgcc
     5821 gaggagggca cgatgctgcg cgccggcgct cccgtgctga aggtccgtac ggagcgcggc
     5881 taccgcgccg tgcgcaccgt cgcggccggg aagatgacga cgctgacggc gaagatcggc
     5941 accgtcgtca ccaccggcaa ggacgtcgcc actgtcgagc ggatcgagtc caccgacgag
     6001 cccctcgtgg cgatggtcta cgtccccggg cacaacggcg cgagcgtacg cgtcaattcg
     6061 caggtcgacc tgaccgtgca gtccgcgccc accgagaagt acggcgtgct gcgcggcagg
     6121 gtgaaggccg tcggcagggc cccgcagaca cggcagcagc tgaccgggtt cctcgggaac
     6181 gcgcagctcg ccgaggagtt ctcgaaggag ggtcagccgg tggcggtgat ggtgcagctg
     6241 gagcgcgcga gcggcaccga gtcgggttac aggtggtcct ccgacgaggg cccgccctac
     6301 gcgctggact ccatgaccat ggccgacgcc gccgtgcacc agccggccca gcgtcccgtc
     6361 gactggctcc tcccgtgagc gccccggaga agaccgcgga ggacgggcag cccgggctcc
     6421 cgccgccggg ccgcggcaag caccgccccg aaggaaaggg cggcggcagg caccgtacgg
     6481 gcaaaggtgc gcccgcgggc cccgcacccg tcccgaaacc cgagttcaag gccatccgca
     6541 gccccaccgt gctgcagatg gaggcggtgg agtgcggcgc cgcggcgctg tcgatggtgc
     6601 tcgggcacta cggacgccac gtgcccctgg aggagctgcg catcgcctgc ggcgtctccc
     6661 gcgacggttc acgggccagc aacctgctga aggcggcccg cagttacgga ctgcaggcca
     6721 agggcatgca gatggagccc gccgcgctcg ctgcggtcgc ggcacccgcg gtgctcttct
     6781 gggagttcaa ccactacgtc gtctacgacg gcatgggacg gcgcttcggc cggcgaggcg
     6841 tgttcatcaa cgaccccgac aaggggcgcc ggttcgtgcc gctggaggag ttcgacacca
     6901 gcttcacggg cgtcgtgctg accttcgaac cgggtgacga cttccacccc ggcggcaggc
     6961 ggccgggctt cctgagcgcc atgccggccc ggttgcgcgg cacgactggc acgatgctgg
     7021 ccgcgctgct cgcgtcgctg ctgctcgtcg ccgtgggcgc ggcggtgccc gcgctgagcc
     7081 gcacgtacat cgacatgttc ctgatcggga acgagacgtc gctgctgagc gtgctgttcg
     7141 cctcgatggg cgccatggtg ctgctgacgg cggtactgac gggcctgcag caggcgaacc
     7201 tgctgcgcgg ccgcatcatc tcctccacgc tcagcagcgc ccgcttcttc cgtcacctgc
     7261 tgagactccc ggtcacgttc ttcgcccagc gcagccccgc ggacctcgtg cagcggctgc
     7321 agtccaacga caccgtcgcg gagaccttgg cgcgggacct ggccgccgcg ggcgtggacg
     7381 ccgtcgtcgt ggtgctctac gcggtgctgc tgtggacgta cgacccgcaa ctgaccctga
     7441 tcggcgtgct catcgccctg ctgaacctcg tcgcgatgcg cgtggtgata cgcctgcggg
     7501 ccaccggcac gcagaagctg cgggccgaca ccgcccgcct gaccaacacc tcctacaccg
     7561 gcctccagct gatcgagacc atgaaggcca cgggcggtga gaacggctac ttccgccgct
     7621 gggccgggca gcacgccact acgctggagg agcagcagaa gctgggcgtg ccgagcgcgg
     7681 ccctcgccgt cgtcgctccc acgctggcca cgctgaacag cgcgatgatc ctgctgatcg
     7741 gcggtatgcg ggcggtcgag ggccacatct cgatcgggct gctcgtggcg ttccaggcgc
     7801 tggtgacgcg cttcaccgca cccatcacgc gcctcaacgg cgtcgcgggc cgcatccagg
     7861 acttcgccgc cgacgtggcg aggctgaagg acgtggagaa cttcccggtg gactcgctct
     7921 attcgcgccg cgccccggca gcgagcaccc gccgcctcaa gggccatgtg tcgctggaga
     7981 acatcacgtt cggctacagc cccctcgaca agccgctgct gacggagttc tcgctctccg
     8041 tcgggccggg ccgccaggtc gcgctcgtcg gcggctcggg gagcggcaag tccaccgtct
     8101 cgcggctcat ctcgggcctc tacagcccgt gggaaggcgt catacgcatc gacgggcagc
     8161 ggctggagga cataccccgc agctcgctgg ccgcctccgt ctccttcgtc gaccaggacg
     8221 tcttcctctt cgagggcacc gtccgcgaca acgtcgcgct gtgggacccg tcgatccccg
     8281 acgaggccgt caccgccgcc ctgcaggacg ccgccgtgta cgaggacttc gcccggcggc
     8341 ccggcggcat ccgctgccgc gtcgagcagg acgggcgcaa cctctccggg gggcagcgcc
     8401 agcgtctgga gatcgcgcgg gcgctggtgc gcaggcccag catcctcgtc ctcgacgagg
     8461 tgaccagcgc gctcgacgcc cggaccgagc aggtcatcat cgacaacctc cgacgccgcg
     8521 gctgcgcctg cgtcgtcatc gcgcaccggc tgagcaccgt ccgcgacagc gacgagatcg
     8581 tcgtgctcga ccacgggacg gtcgtcgaac gcggccgcca cgaggagctg gtcgcggccg
     8641 gcggccagta cgccgagctg gtcaaggagc actgaggtgg catccgcgca cggcccggga
     8701 gagcagagca ccgccggcta cggacccggt gcgtacgagg aggcgccgca cgacggcgtc
     8761 gcgacgtacg agcacgggaa cgggacgtac gagcacggga acgggacgta cgagcacggg
     8821 aacggcgccg caccctacga gcacggcgcc gggacgtacg ggaacagcac gccggagacg
     8881 gcggccggcg ccgaagtgcc gcacgcgggc ggcgaggtca cgccgtccgc cgccgcgccg
     8941 tcagcggcgt acggcaccgc cgcgtccgcc accgcggagc ccgcggccac gccgtacggc
     9001 accgccgcgt ccgatcccgt cgtcgacgcg ttcggctccc tcggcgaacc ggcggacagc
     9061 gacggccggc gcagcatgcc cctcgaaggt ccgcacgtgc tgtggctggt gacggccggg
     9121 gcgatggacc tgttcgccgt cgacgccgcc gcgcaggggc actggcactt cctcggccgg
     9181 ctggaggcgg gcaccctcct gctcggaccc gtcgagggcc cggagcacac cctcgtcggc
     9241 aggcccctgc gcgaatgcgg cctgcgccgc atcgagttgc gggagctgtt cacgcccgag
     9301 cacgacgcgt acggcgcgac gtccccgtac ggaaccccct acggcgccgc cggacacggc
     9361 gggggcgccg cgaccccgtc cgcgctcgac acggccttcg cacttggcgt cggacgcggc
     9421 ctccgcgtac tccacgaggc gcccctggac ggcgaggtga cgcctgaggc cgggcacccc
     9481 ggcatcaccg ggggcacgga cgacgacgag atccagtgga tgcgcctgga gcccgggagc
     9541 gtccagtacg gcgccttctt cagccaggag gccgcgtcgc agctcctggt cgacggccgg
     9601 gcctggcagc gcatggtgga ccagcagttc cggctgctct ccgccctgga ccgctggatc
     9661 gagcggctgg agcgcgccca cgaggaccgt acggccgccg gcatcgaggc cggcgagacg
     9721 gtacgggccc aggccgacca ggcgctgctg gcctccatcg gcaccacggg gaagggcgct
     9781 gccgaagccg cccgcgccac ggacgacgac acgctcaccg tcgcccggct cgccgccggt
     9841 gccgccggga tcaagctctc cgccccggag gagagcagct cgacgggcga ccgcaccaac
     9901 cccgtggagc gcatcgcgct cgcctcacgg gtccgtaccc gcgtcgtcaa actggacggc
     9961 cgctggtggc ggcggaacgc gggcccgctg gtggggcacc gttcgggaag cggcgctccg
    10021 gtggcgctgc tgtggcgccg cggccggtac gaggcggtgg acgcctcggg cgagcgcgtc
    10081 cggatcggcc ggtccgcggc gggccggttc gagccgcgtg ccgtgatgtt ctaccggccg
    10141 ctgcccgaag agcccctcaa cgcctggcag ttgctccgct tcacgctccg gggcacccgc
    10201 atggacgtac gga
//
