LOCUS       NZ_BMMN01000019        21113 bp    DNA     linear   CON 22-DEC-2024
DEFINITION  Microbispora bryophytorum strain CGMCC 4.7138 sequence19, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMN01000019
VERSION     NZ_BMMN01000019.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Microbispora bryophytorum
  ORGANISM  Microbispora bryophytorum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 113231)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 202X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645855.1-RS_2024_12_22
            Annotation Date                   :: 12/22/2024 07:39:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,203
            CDSs (total)                      :: 7,136
            Genes (coding)                    :: 7,048
            CDSs (with protein)               :: 7,048
            Genes (RNA)                       :: 67
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1, 2 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 88
            CDSs (without protein)            :: 88
            Pseudo Genes (ambiguous residues) :: 0 of 88
            Pseudo Genes (frameshifted)       :: 16 of 88
            Pseudo Genes (incomplete)         :: 78 of 88
            Pseudo Genes (internal stop)      :: 7 of 88
            Pseudo Genes (multiple problems)  :: 11 of 88
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:18:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 72679
            Orig. end                         :: 93792
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMN01000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21113
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21113
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21113
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11113](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11113
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            40..1443
                     /locus_tag="IEY80_RS32770"
                     /old_locus_tag="GCM10011574_66360"
     CDS             40..1443
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541720.1"
                     /locus_tag="IEY80_RS32770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66360"
                     /product="aldehyde dehydrogenase (NADP(+))"
                     /protein_id="WP_229689952.1"
                     /sec_met_domain="Aldedh (E-value: 1.5e-45, bitscore: 148.2,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDAVRTAVERAAAAGEAWRATPPAERATVLEGVSDALLKHAEEL
                     WPAAAEETRLPEARLRGEIARTAAQFRLFAGVLRDGGWVEAVIDHPDPGATPPCPDLRR
                     MNHPLGVVAVFAASNFPFAFSVAGGDTVSALAAGCPVVVKAHEGHPRTSDLTASVVRQA
                     LPDPDLLGLVHGFETGAPLVQHPLVTAVGFTGSLGGGTAIQKLIDERPDPIPFYGELGS
                     VNPVVVLPSADPAEVASGFAASLTLGVGQFCTNPGLVFVPAEGGFEQAVAEAVAATSGG
                     PMLTAKIREGYLRASGRLAGRLTVLASGGAVDGIIPQVFAADLEAFAEGLPELGEECFG
                     PSAIVVRYRDPADLPAVLRRLPGSLTATVHAAGPEEARDLVPVLNRLAGRLIWNGWPTG
                     VAVSWAMHHGGPWPASTAPAHTSVGAASIGRWTTPVAYQDWPADLLPPELRDDNPLGVP
                     QRVDGRLRA"
     gene            1576..2004
                     /locus_tag="IEY80_RS32775"
                     /old_locus_tag="GCM10011574_66370"
     CDS             1576..2004
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019013.5"
                     /locus_tag="IEY80_RS32775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66370"
                     /product="ester cyclase"
                     /protein_id="WP_167748459.1"
                     /sec_met_domain="PF07366 (E-value: 5.5e-20, bitscore: 64.2,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEVVDRYVSAFNAHDLGAIMDCYCSKPVTVGPGGPVEGRSEIAS
                     YYTRTWQAFPDMHFTVLRKVVDGAATAVTAVATGRHTGPFALTTGDVLQSTGRYISVRC
                     CWFFALQEGVIVNQQIFYDQLELYLQLGLPLSRLGPPD"
     gene            complement(2054..3340)
                     /locus_tag="IEY80_RS32780"
                     /old_locus_tag="GCM10011574_66380"
     CDS             complement(2054..3340)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131342.1"
                     /locus_tag="IEY80_RS32780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66380"
                     /product="polysaccharide lyase family 1 protein"
                     /protein_id="WP_142575275.1"
                     /transl_table=11
                     /translation="MPGRSLLLSAALAITAAAPVLTAAPAAAGKPADLGRQTLPAGDGW
                     ASAGAGTTGGAAAPAPNVHVVTDRAGLAAALASPGPRIIYVKGVVDVDRTCGDFATGGY
                     TLAGYLAAYDPAVWGRDTEPSGPVEDARAASAAAQTKYIKLKVPSDTTIVGLPGATIRH
                     INLHVDKADNVIIRNIRFEDTADCFPQWDPTDGADGNWNSLYDNISVTGSTHVWIDHNT
                     FTDGDNPDANQPVYFGRPYQVHDGQADITSASDYVTVSWNSFSDHDKTMLIGSTNNPAT
                     DRGKLSVTVHHNEFSGNLQRLPRVRFGKVHVYNNYYQVPDAEPFEYALGVGVESQIYAE
                     NNYFRLSRSVDPGDVLYDWGGTTLTAKGNLLRVGGKERPIDLIAAYNANHDPDLGTDAG
                     WTPALHTGIDPAETVRREVSRHAGAGEIH"
     gene            complement(3398..4315)
                     /locus_tag="IEY80_RS32785"
                     /old_locus_tag="GCM10011574_66390"
     CDS             complement(3398..4315)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017601404.1"
                     /locus_tag="IEY80_RS32785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66390"
                     /product="5-dehydro-4-deoxyglucarate dehydratase"
                     /protein_id="WP_142575274.1"
                     /transl_table=11
                     /translation="MTFDGLLFFPVTPCDEEERLDLEVFRRHVRQGVEAGCGAVFACCG
                     TGEFPSLSLRDYTACVAAAVEEAAGRVPVVAGTGYGTAMALEFAKAAQDGGASALLALP
                     PYLVQAGQDGLRRHYEAIADGTRLPVILYQRDNAVFEPETVAALAEHPGVIGLKDGHGD
                     LGLMRRIMEAAPPGMLYFNGLPTAELSQRGYRDLGVVRYSSAVFCFLPGLALACYRALR
                     DGRDDVANRLIEGFYRPLVDLRGQGPGYAVSLIKAGVRLRGLDVGPVRRPLSDPSPEHL
                     GRLAALIDRGLALLEELERSPDPA"
     misc_feature    4505..4520
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            4588..5445
                     /locus_tag="IEY80_RS32790"
                     /old_locus_tag="GCM10011574_66400"
     CDS             4588..5445
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131343.1"
                     /locus_tag="IEY80_RS32790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66400"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_142575340.1"
                     /transl_table=11
                     /translation="MRRRAVPYLLISPTVALIAVFLVYPIASVAYYSLQHRNLTRPWAD
                     GFAGLGNFRQMLFEDEVFWHSLGFTAKWVVAEIGLQLILGLALALIVNESFIGRGLARS
                     LVFSPWAVSGVLTTGIWILLYTPSTGVLRFLGQPEAAVLGNPDTVFPAVVVTELWRGVP
                     FFAILLLAGLQGIPGELYEAAAVDGAGRIRRFLHVTLPHLRDAIVLATLLRGVWEFNNV
                     DLLFTLTGGGPAQVTTTLPLYVAQRAVDSKDFGYGSALTMAGFVILLFCSLLYLRLSRF
                     GEER"
     gene            5465..6343
                     /locus_tag="IEY80_RS32795"
                     /old_locus_tag="GCM10011574_66410"
     CDS             5465..6343
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131344.1"
                     /locus_tag="IEY80_RS32795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66410"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_142575273.1"
                     /transl_table=11
                     /translation="MSADVMIRPGTRAVPAGTRRRRRRDPGRVLRLYVPLGMYLVFTLV
                     PFYWMLVFALRPAGSTDPVPWPITFEHFETVWNDIGYAVFFKNSVIVGVWSLLVTTVIA
                     VMGGYALSRYRFRGRGLFMVVLLCTQFIPGAMMLIPLFSIFKSLGLINSLASLIVADTV
                     FNLPLSIILMSGFVSAVPFTVEEAAMVDGCSRLRGFLAIVLPQLRPGLIAVGSFAFIHT
                     WNNFLFALMFVSKQDSFTIPVGLSYTIGEYSADFGALAAGGVVAALPVVCVFAVVQRYL
                     VHGISAGAVKG"
     gene            6392..7681
                     /locus_tag="IEY80_RS32800"
                     /old_locus_tag="GCM10011574_66420"
     CDS             6392..7681
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888232.1"
                     /locus_tag="IEY80_RS32800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66420"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_142575272.1"
                     /transl_table=11
                     /translation="MKMKVAWAALAVLAVTATGCGSDSGSGEGSGKTTITFWDNNGGAR
                     TPIYQELIKRFEAANPSIHVEYVGIPIASVQQKYDTAIAGGDTPDVGGVTTSYLANLTG
                     QQALEPADEWLTTSAVNGKLAAPMLDSVRKTVPDGKLYLVPGTSNMDVVWYLKDKLQQA
                     PGTWDEFFADADKLTKKPDAYGYTIRGGAGSIFQILAEMYSYSGVSEFFDASGKSTVND
                     PKNVEFLTKMAGLYKKDTPEADVTNDFPKMVAAFGTGKIAMMHHNLGSYNDHVKAHGKD
                     KIGAFALPTGPGGRRTVVANPVDGFAVFKGSEHKDAAWKFVEFLVSHEGNSYWNQQTGQ
                     IPANTEAQGDSWLQGLEHLKTAVDTLNDPNTQVVSPPYYLPQFSSITKADTEPLFQKVL
                     LGQMQPQEFLDTLAQKLTDAQAEWKKATGG"
     gene            7773..8936
                     /locus_tag="IEY80_RS32805"
                     /old_locus_tag="GCM10011574_66430"
     CDS             7773..8936
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268: mandelate racemase/muconate lactonizing enzyme"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131346.1"
                     /locus_tag="IEY80_RS32805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66430"
                     /product="enolase C-terminal domain-like protein"
                     /protein_id="WP_142575271.1"
                     /transl_table=11
                     /translation="MAVVERVIVTVFTTVTRSVVDGHGHRHPGPPREVREALLTVTDSD
                     GATGHCLAAPDTVRETVITGHIGPALIGQDSLDRERLWHRVARRQRGAQGNLSDRALSA
                     ADQALWDLAGRRLGLPVWKLLGGARSEVPAYASTMCGDDIPGGLATPEDYAAFAKELVS
                     RGYRGIKLHTWMPPMPYGVDRDIEACAAVREAVGPDVALMLDSNHWYSRSEALTLGRAL
                     DELNFAWYEEPMEEASVQSYRWLADQLRTPILGPETSWGKHMARAEWVAAGACDILRVG
                     VVGSGGIIPAVKAVHLAESFGMDCEIHGNGSGALAVIGATLCGQWYERGLLHPHSDYDT
                     PAPHLRSIVDPLAGGKVRMPDTPGLGDDLDTDYIASRTVASWGTGSQ"
     gene            8971..9744
                     /locus_tag="IEY80_RS32810"
                     /old_locus_tag="GCM10011574_66440"
     CDS             8971..9744
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131347.1"
                     /locus_tag="IEY80_RS32810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66440"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_142575270.1"
                     /transl_table=11
                     /translation="MAEPVPHVKSALRTVELLDFFAQYPGLHSLTDLQGKLGYPKSSLH
                     ALLRTLVDLGWIETDVTGTLYRIGMRALLVGATYIDGDPVVQLAHDALDWLAEVTGETV
                     HLARLDHFDIVYLATRASRHYLRPFSRVGRRLPASTTSLGKAILASRDEGEVRAMLPAE
                     LPSLTAHTIVDAEELLVDLHRVRKQGYAVDREENTEGLRCFGVALHISDPPRDAISCSV
                     PIPRLTPEREKEIASCLLEARERIERSAMRQRRAY"
     misc_feature    complement(9943..9957)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.02"
                     /tool="antismash"
     aSDomain        10001..10279
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IEY80_RS32815_Pantocin_Microcin_RRE.1
                     "
                     /evalue="1.80E-16"
                     /identifier="RREFam017.1"
                     /label="IEY80_RS32815"
                     /locus_tag="IEY80_RS32815"
                     /protein_end="93"
                     /protein_start="0"
                     /score="51.1"
                     /tool="antismash"
                     /translation="MRLPRVKAEHRPYRLGHDRIRIGGSIYGIAGEISDPNGHAWAALS
                     AMDGTRTPSDVADHLCVLFPGLRRAHATGVVDLLLRSGYFEDAAAPPP"
     gene            10001..11113
                     /locus_tag="IEY80_RS32815"
                     /old_locus_tag="GCM10011574_66450"
     CDS             10001..11113
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013094.5"
                     /locus_tag="IEY80_RS32815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66450"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_142575269.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 6.6e-16,
                     bitscore: 51.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 1.4e-44, bitscore: 145.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLPRVKAEHRPYRLGHDRIRIGGSIYGIAGEISDPNGHAWAALS
                     AMDGTRTPSDVADHLCVLFPGLRRAHATGVVDLLLRSGYFEDAAAPPPSDLSAAERERY
                     SRNLAFFRWVDLVPRAHGWEAQVALKRARVLVLGLGGTGSHAAWALAAAGVGTIHCVDR
                     DVVELSNLTRQALFTEADLGKPKADVVVDRLGRVNSSVHVTGETRAVESVADLSALLTG
                     FDALALCADEPRGRDGIRIWANRACLTAGVPWAVGGYRGPLVSVGVFTADGPCYECLTA
                     TIEATTTPGVHVDLGGPGVLAPSAGISGHLTAQAVISMLAGIPATLRSHVTGINLVAPE
                     QHVYMLHGASPECAGCATRQRGNRDGGIDA"
     misc_feature    10043..10045
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11336..11345
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.08"
                     /tool="antismash"
     gene            11365..11976
                     /locus_tag="IEY80_RS32820"
                     /old_locus_tag="GCM10011574_66460"
     CDS             11365..11976
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF045158.2"
                     /locus_tag="IEY80_RS32820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66460"
                     /product="DUF6879 family protein"
                     /protein_id="WP_142575268.1"
                     /transl_table=11
                     /translation="MKIPRLEAVPGTMLPMEEYAADFLEIFHDVDGVIWKLERAQSFDE
                     GTDPSWNAMREGDWRRSLELLDEARAAIAADLPAKGELRRVRVVETPLTAYLQWELHLL
                     ALRMRLGERGRVLDAREVAAIEMDGPLPELVVFPGRRMYHVQYEQGGACRGARRIDDDE
                     AVRTWGSIVSSLYDRGEDLLAYVDKRVMPLAPPRIGVSAR"
     gene            11973..13199
                     /locus_tag="IEY80_RS32825"
                     /old_locus_tag="GCM10011574_66470"
     CDS             11973..13199
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS32825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_66470"
                     /product="hypothetical protein"
                     /protein_id="WP_142575267.1"
                     /transl_table=11
                     /translation="MTRVRLRPLGFREDGDGWVVGRVETGVCIAVPHAGKRAIELLDSG
                     RTIPETREELRTELRAELDVSAFVDDLAAVGMVESIGDRVFADTGTPAPSLPRITGRMV
                     RWTLSPVLHAALGLLVFSGFVAAVLRPEVVPRWRSLLWSDHGTLIVLSEVALVAVLVSL
                     HELAHLLTARAAGVPGRIRVDTRLQFLAAQTDVSGIWLAERRIRLTVYLAGIAVDASVL
                     AGCLLGTALFGGNVLLSVIALTEMTGLALQFFVFMRTDLYFLVQDLAGCRNLYADATAF
                     VLHLLRRVARASTSDPLAGLERRQRRFVRLYSALLVAGTGLCLGVFLLISVPFTVALLA
                     RSIDGLSRHDDMLGVVDALVTLGVVAGYQGVWARAWLRRHGPRVRRLVARLTRPARSAG
                     LRGVCPPRD"
     gene            complement(13307..13807)
                     /locus_tag="IEY80_RS32830"
                     /old_locus_tag="GCM10011574_66480"
     CDS             complement(13307..13807)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012417.5"
                     /locus_tag="IEY80_RS32830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66480"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_142575266.1"
                     /transl_table=11
                     /translation="MTDGLLLPPGGGDTIQAMTLKVGAEQTAGWSVFEAVVAPGFDVGA
                     HLHHEAEEMFYVIDGELDLLAFHPAAAAGSDWRSWRSDSGAEVLRGGPGSFMHVPAGCP
                     HAFFNPGPEPARMLFVVTPAGHETYLRELTRMLAAGPPDQAEITALRARHDIQQLTPLT
                     NRA"
     gene            complement(13819..14694)
                     /locus_tag="IEY80_RS32835"
                     /old_locus_tag="GCM10011574_66490"
     CDS             complement(13819..14694)
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017604182.1"
                     /locus_tag="IEY80_RS32835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66490"
                     /product="NmrA/HSCARG family protein"
                     /protein_id="WP_142575265.1"
                     /transl_table=11
                     /translation="MSDPVLVVGATGQQGGATARRLLARGRSVRALVRDPGGSAARALE
                     ESGAELAVGDLDDEGSLRRAMGGVDGVFLALTMMQGPKITVEGAAAEERRGLTVARLAA
                     EIGTGHLVYSSVPGTDHPSGIPHIESKARIEREIHALGLPATILRPVSFMENFTTYNRP
                     VLEDGTLVVRLPAQPGTPMQLIGVEDIGVFAALAFERPGRFLGRTVDLGGDELTPPEIA
                     ATFGRVCGLPARFERTPIEQVRAFDEWVARMFEFFEEQPPAQVDLRALRPEHPGLMTLE
                     TWLRATGWKA"
     gene            14727..15749
                     /locus_tag="IEY80_RS32840"
                     /old_locus_tag="GCM10011574_66500"
     CDS             14727..15749
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037627.5"
                     /locus_tag="IEY80_RS32840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66500"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_142575264.1"
                     /transl_table=11
                     /translation="MDHGRHDNETASGGPGTRAASNAPGRRARASGRRAELGAFLRARR
                     ARLHPADVGLPEGDPALRRTPGLRREEIAELSGVGVTWYTYLEQGRDISASAQVIDALA
                     RALLLDPDEHRHLRDLAGLAPPDTPETPSGEAERPRDRLRRLVDAAAPNAASVYDARFD
                     YLAWNTPYTLLRHDPLTLPPGRRNLLWMMFTDAGNRARMVRWEPAARALISQFRAAMGH
                     RQGDPAFTALVAELSEASPEFREWWADYPVRRFRPATVAIDHPEIGRLDLEMFQLRPAE
                     HPDLLLVLQVPADEDGRRRVTALLDGRSAPDGDPGGAPDGSASQGGLPARRPGNRSHPG
                     "
     gene            15760..18297
                     /locus_tag="IEY80_RS32845"
                     /old_locus_tag="GCM10011574_66510"
     CDS             15760..18297
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015616 - DNA translocase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018655124.1"
                     /locus_tag="IEY80_RS32845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66510"
                     /product="DNA translocase FtsK"
                     /protein_id="WP_142575263.1"
                     /transl_table=11
                     /translation="MATRTSGQGSGKRPASRSGSRTASAKRSPAGSRGRAAPRPAPKRP
                     VATGQDPISWFFLVIGKLVIGMWMLVANGVGMAARALGQGARDLDPAHRRDGQGLSVLA
                     GAIVLAALTWRETKTGFAEFVDAVVRGTVGSLAWAVPVLLALLAWRLLRHPDQNAETGR
                     MGIGWTALLAGILGIVHVAHGTPYPSGGPNDGMDNVSAAGGMIGFIVSAPPSSILPAFI
                     TIPLLVMLSGFGLLVITATPVHRVPERLAEIQHMLFHRPEETGEPRKTPAPARRRTRKQ
                     QGGRRDAEGGDGVKPYDTPVLSDKEHSPEIVPGLMDDAAESAEPTEPEIPKPVPQPPLP
                     TPAPRKVEQLVLSSQEGPYTLPDLTTLRPGSAPKQETKANRTVVNALTSVLEQFAIDAQ
                     VVGFTRGPTVTRYEIELGPAVKVEKVTALTKNIAYAVKSADVRILSPIPGKSAIGVEIP
                     NVDKDLVSLGDVLRSRVAQADHHPMIVGLGKDVEGRTIVANLAKMPHILIAGATGAGKS
                     TCINGLISSILLRATPDEVRMVLVDPKRVELTSYEGIPHLITPIITNPKKAAEALEWVV
                     GEMDRRYDDLAASGFRHVDDFNKAVRAGKLVPPPGSERVYQPYPYLLVIVDELADLMMV
                     APRDVEDSIVRITQLARAAGIHLVIATQRPSVDVVTGLIKANVPSRLAFATSSLADSRV
                     ILDQPGAEKLVGQGDALFLPMGASKPMRLQNAFVSEKEIADIVAHCKAQMQAEYREDVA
                     APAAAKREVDEEIGDDLDLLIQATELIVSTQFGSTSMLQRKLRVGFAKAGRLMDLLESR
                     NVVGPSEGSKAREVLAKPDDLPGLLAEMRGETG"
     gene            18516..19229
                     /locus_tag="IEY80_RS32850"
                     /old_locus_tag="GCM10011574_66520"
     CDS             18516..19229
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024855.5"
                     /locus_tag="IEY80_RS32850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66520"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_167748458.1"
                     /transl_table=11
                     /translation="MAEARERAGLTVRQLSERTRVRETVIERFERDDFSVGDFYARGHI
                     RTIASDLGLDPDEILRQYEQENADIASPVKASAVFRGDVGERARRVPNWTMAVAVALAI
                     VAVVVIARMLGGSGGKTGPTAAQLPVTAPHARHDKGHEKKTVEEALAPGVVVVKVTARK
                     QSYLSVKDAKGKEIFQGTLPEGKTTTYSAKDRMKVTIGDAGAVRLEVNGRDLGTPGKDG
                     QMIRRTFDAGGPSPR"
     gene            19260..20672
                     /gene="rimO"
                     /locus_tag="IEY80_RS32855"
                     /old_locus_tag="GCM10011574_66530"
     CDS             19260..20672
                     /EC_number="2.8.4.4"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008172 - S-methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016782 - transferase activity,
                     transferring sulphur-containing groups [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0018339 -
                     peptidyl-L-beta-methylthioaspartic acid biosynthetic
                     process from peptidyl-aspartic acid [Evidence IEA]"
                     /codon_start=1
                     /gene="rimO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888901.1"
                     /locus_tag="IEY80_RS32855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_66530"
                     /product="30S ribosomal protein S12 methylthiotransferase
                     RimO"
                     /protein_id="WP_142575261.1"
                     /sec_met_domain="PF04055 (E-value: 2e-23, bitscore: 76.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSRRTVSLITLGCARNEVDSEELAARLEAAGWHTDDDDPDVVVV
                     NTCGFIDSAKKDSIDTLLAAADSGAKVVAAGCMAERYGAQLAGALPEATVISFDDYAAI
                     GERLDDVLAGRPLVPHSPRDRRTLLPITPVERAAARAHIPGHAQEDPLPEGVAPASGPR
                     TLRKRLGSGPVASMKLASGCDRRCTFCAIPAFRGSYVSRRPEDLLAEAAWLAGQGVREL
                     VLVSENSTSYGKDLGDLRALEKLLPPLAATEGIERVRVSYLQPAELRPGLLDVIASTEG
                     VVPYFDLSFQHASGTVLRRMRRFGDPKRFLDLLAQIRDRAPEAGVRSNFIVGFPGETQE
                     EFDELVGFLEEARLDVIGVFGYSDEEGTDAYGFEGKLGQDVIDERVATLTELAEELTAQ
                     RAEERIGTELEVLIEEDLGDGGYEGRAAHQGPEVDGAVTVQGIGLVPGQIVQAVAVDSE
                     GVDLIARIKAGT"
ORIGIN
        1 tcgagaatct tacggtgagg ggatgaggtg accgaccagg tgaacgatgc cgtccggacg
       61 gcggtcgagc gggccgccgc ggcgggcgag gcgtggcggg cgacgccccc ggccgagcgc
      121 gccaccgtgc tcgaaggcgt ttccgacgcc ctgctcaagc acgccgagga gctgtggccg
      181 gccgcggcgg aggagacccg gctgcccgag gcgcggctgc gcggcgagat cgcccgtacg
      241 gccgcgcagt tccggctgtt cgccggcgtc ctgcgggacg gaggctgggt cgaggcggtg
      301 atcgatcacc ccgaccccgg cgccactccg ccgtgtcccg acctgcgccg gatgaaccac
      361 ccgctcggtg tcgtggccgt cttcgcggcc agcaacttcc ccttcgcgtt ctcggtggcg
      421 ggcggcgaca cggtgtcggc gctcgcggcc ggctgcccgg tcgtggtcaa ggcccacgag
      481 gggcaccccc gcacctccga cctgaccgcc tccgtcgtac ggcaggcact gcccgacccc
      541 gacctgctcg ggctcgtgca cgggttcgag accggggccc cgctggtgca gcacccgctc
      601 gtcacggcgg tcggcttcac cggctcgctc gggggcggga cggccatcca gaagctgatc
      661 gacgagcggc ccgaccccat cccgttctac ggcgagctgg gcagcgtcaa tccggtcgtc
      721 gtgctgccct cggccgaccc cgccgaggtg gcctccggct tcgcggcctc gctgacgctg
      781 ggcgtggggc agttctgcac caaccccggc ctggtgttcg tcccggcgga gggagggttc
      841 gagcaggccg tcgccgaggc ggtcgccgcc acctccggcg ggcccatgct gaccgccaag
      901 atccgcgagg gctacctgcg ggcgtccggc cggctggccg ggcggctcac cgtgctggcg
      961 agcgggggcg cggtggacgg catcatcccg caggtcttcg ccgccgacct ggaagcgttc
     1021 gcggaggggc tgcccgagct gggggaggag tgcttcggcc cgtcggcgat cgtcgtccgc
     1081 taccgcgacc ccgccgacct gcccgccgtg ctgcgccggc tgcccggatc gctgaccgcg
     1141 accgtccacg cggccggccc ggaggaggcc cgcgacctcg tgccggtgct caaccggctg
     1201 gccgggcggc tcatctggaa cggctggccc accggtgtcg ccgtcagctg ggcgatgcac
     1261 cacggcggcc cctggcccgc ctccacggcc ccggcgcaca cctccgtcgg cgcggcctcg
     1321 atcgggcgct ggacgacccc cgtggcgtac caggactggc cggcggacct gctgccgccg
     1381 gagctgcgcg acgacaaccc cctcggcgtg ccgcaacgtg tggacggccg cctgcgcgcc
     1441 tgaggccgcc cccgcgtatc cgcgtcgctc tcccctcggg gggagcggcg cctccatgct
     1501 cggacccgga tgaagagggc gaaagccgcg tctcgatagc ctggacttct ggcggcggga
     1561 atcgggggtc tcgcggtgga cgaggtggtg gaccgatatg tcagcgcgtt caacgcccac
     1621 gatctgggcg cgatcatgga ctgctactgc tccaagcccg tcacggtggg gccgggcggc
     1681 ccggtggagg gacgctcgga gatagcgtcc tattacaccc ggacctggca ggcgttcccg
     1741 gacatgcact tcacggtgct gcggaaggtc gtggacggcg cggccacggc ggtcaccgcg
     1801 gtggcgaccg gcaggcacac cgggccgttc gcgctcacca cgggtgacgt gctccagagc
     1861 accgggcggt acatcagcgt gcggtgctgc tggttcttcg ccctgcagga gggcgtgatc
     1921 gtcaaccagc agatcttcta cgaccaactg gagctgtatc tccagctcgg gcttccgctg
     1981 tcccgcctcg gtccgccgga ctgagggtgc gcgcggcccc cgcgcacgca caggggccgc
     2041 gcgccgccgg ccgtcagtgg atctcgccgg ctcccgcgtg ccgggagacc tctctgcgta
     2101 cggtctcggc ggggtcgatc cccgtgtgca gggccggcgt ccagcccgcg tccgtgccga
     2161 ggtcgggatc gtggttcgcg ttgtaggcgg cgatcaggtc gatgggccgc tccttgccgc
     2221 cgacccgcag caggttgccc ttggccgtca gcgtcgtgcc gccccagtcg tagagcacgt
     2281 cgcccgggtc cacgctccgg ctcagccgga agtagttgtt ctcggcgtag atctgggact
     2341 ccacgcccac gcccagcgcg tactcgaagg gctcggcgtc gggcacctgg tagtagttgt
     2401 tgtagacgtg caccttgccg aaccgcacgc ggggcagccg ctgaaggttg ccggagaact
     2461 cgttgtggtg cacggtgacg ctgagcttgc cccggtcggt ggcggggttg ttggtcgagc
     2521 cgatcagcat cgtcttgtcg tggtcggaga acgagttcca cgacacggtc acgtagtcgg
     2581 acgcgctggt gatgtccgcc tgcccgtcgt gcacctggta gggccggccg aagtagaccg
     2641 gctggttcgc gtcggggttg tccccgtcgg tgaacgtgtt gtggtcgatc cagacgtggg
     2701 tcgagccggt gaccgagatg ttgtcgtaga gggagttcca gttgccgtcg gcgccgtcgg
     2761 tggggtccca ctgggggaag cagtcggcgg tgtcctcgaa tcggatgttg cggatgatga
     2821 cgttgtccgc cttgtccacg tgcaggttga tgtgccggat ggtcgctccc ggcaggccaa
     2881 cgatcgtggt gtcggacggc accttgagct tgatgtattt cgtctgcgcc gcggcggagg
     2941 ccgcccgcgc gtcctccacc ggcccggacg gctctgtgtc gcggccccac accgccgggt
     3001 cgtacgccgc gaggtagccg gccagggtgt agccgccggt ggcgaagtcc ccgcaggtcc
     3061 tgtcgacgtc gacgacgccc ttgacgtaga tgatgcgggg gccgggggag gcgagggccg
     3121 cggccaggcc cgcgcggtcg gtgaccacgt ggacgttcgg cgcgggggcc gccgcgccgc
     3181 cggtggtgcc ggcgccggcc gaggcccagc cgtcgcccgc gggcagcgtc tgccgcccga
     3241 gatcggccgg cttcccggcc gccgcggggg ccgccgtcag cacgggggcg gcggccgtga
     3301 tcgcgagggc ggccgacagg agtagggatc ttccgggcat gactgtctcc gttccgcggt
     3361 cgctcccccg ggacgagtcc gtacgtgtca ccggcgctca ggccggatcg ggcgaccgct
     3421 ccagttcttc gagaagggcg agaccgcggt cgatcagcgc ggcgagcctg ccgaggtgct
     3481 cggggctggg atcggacaac ggccggcgga cgggtcccac gtccagacca cgcaggcgca
     3541 cacccgcctt gatgagcgag acggcatacc ccgggccctg gccgcggagg tcgaccaggg
     3601 gacggtagaa gccttcgatc agacggttcg cgacgtcgtc gcggccgtcc cgcagcgccc
     3661 ggtagcaggc gagcgcgagg ccggggagga aacagaagac ggcggaggag tagcggacca
     3721 ccccgaggtc tcggtaaccg cgctgggaca gctccgccgt cggcaggccg ttgaagtaga
     3781 gcattccggg cggggcggcc tccatgatcc ggcgcatgag gccgaggtcg ccgtggccgt
     3841 ccttgagccc gatgacgccc gggtgctccg cgagcgccgc gaccgtctcc ggctcgaaga
     3901 cggcgttgtc ccgctggtag aggatgaccg gcagccgggt gccgtccgcg atcgcctcgt
     3961 agtggcggcg caggccgtcc tgcccggcct gcacgaggta cggcggcagc gcgagcaggg
     4021 ccgaggcccc gccgtcctgc gccgctttgg cgaactccag ggccatcgcg gtgccgtagc
     4081 cggtcccggc gaccaccggg acgcgcccgg ccgcctcctc gaccgccgcg gccacgcagg
     4141 cggtgtagtc gcgcaggctg agcgagggga actcgccggt gccgcagcag gcgaacaccg
     4201 cgccgcaccc cgcctcgacg ccctgccgca cgtgccggcg gaacacctcg aggtcgagcc
     4261 gctcctcctc gtcgcacggg gtgaccggga agaacagcag gccgtcgaat gtcaccggct
     4321 tcctccgtca ttctcctgaa ctatcagtca ttcgacatcc atctgaacct gattcatatg
     4381 catgaacacc gggaccgtac ggcgcgcacc ggcgcgcggt caagacgcgg gcccccaaag
     4441 ggtgaatatc tcgaatagga cacgagttct tgacaggacc aaggcgcgac atcaccgttg
     4501 atccgtccac gtttgtgaac tacgttcagg aatatgtctt gagcctggtt cgggaaaagc
     4561 cgcagaggag atgcgccggt gacgacgatg cgccgcaggg ccgtgccgta cctgctgatc
     4621 tcaccgacgg tcgcgctcat cgccgtgttt ctcgtctacc cgatcgccag cgtcgcgtac
     4681 tacagcctgc agcaccgcaa cctcacccgg ccgtgggcgg acggcttcgc cggtctcggc
     4741 aacttccggc agatgctgtt cgaggacgag gtcttctggc acagcctggg cttcaccgcg
     4801 aaatgggtgg tcgccgagat cggcctccag ctgatcctcg ggctggccct ggccctgatc
     4861 gtcaatgaaa gcttcatcgg cagggggctc gcccgctcgc tcgtcttctc accctgggcc
     4921 gtctccgggg tgctgacgac gggcatctgg atcctgctct acacgccgag taccggggtg
     4981 ctgcgcttcc tcgggcagcc cgaggcggcg gtcctcggca accccgacac ggtcttcccg
     5041 gccgtggtgg tgaccgagct gtggcgcggc gtgccgttct tcgcgatcct cctgctcgcc
     5101 ggcctgcagg gcatcccggg cgagctctac gaggcggcgg cggtggacgg cgccgggcgg
     5161 atcaggcgct tcctccacgt cacgctgccg cacctgcggg acgcgatcgt gctggccacg
     5221 ctgctgcgcg gagtctggga gttcaacaac gtcgacctgc tcttcacgct caccggcggc
     5281 ggcccggcgc aggtcacgac cacgctgccg ctgtacgtcg cgcagcgggc ggtcgactcc
     5341 aaggacttcg ggtacggctc ggcgctcacg atggcgggct tcgtgatcct gctgttctgc
     5401 tccctcctct acctccggct cagccggttc ggcgaggaac gatgaagagg cgaggggttt
     5461 cacgatgagc gccgacgtca tgatccgccc gggcacgcga gcggtgcccg cggggacccg
     5521 ccgacggagg agacgcgatc ccggccgcgt gctgcggctc tacgtccccc tcgggatgta
     5581 tctggtcttc accctcgtgc cgttctactg gatgctcgtg ttcgccctgc ggccggccgg
     5641 atcgaccgac ccggtgccct ggccgatcac gttcgagcac ttcgagaccg tctggaacga
     5701 catcggctac gcggtgttct tcaagaacag cgtgatcgtc ggggtctggt cgctgctggt
     5761 caccacggtc atcgcggtca tgggcgggta cgcgctgtcg cgctaccggt tccgcggccg
     5821 gggcctgttc atggtcgtgc tgctgtgcac ccagttcatt cccggcgcga tgatgctgat
     5881 cccgctgttc tccatcttca agtcactcgg cctgatcaac agcctggcca gcctcatcgt
     5941 cgccgacacc gtcttcaacc tgcccctgtc gatcatcctg atgagcgggt tcgtctcggc
     6001 cgtgccgttc acggtcgagg aggccgcgat ggtcgacggc tgcagccggt tgcgcggctt
     6061 cctcgcgatc gtgctgccgc agctgcgacc cggcctgatc gccgtggggt cgttcgcctt
     6121 catccacacg tggaacaact tcctgttcgc gctgatgttc gtcagcaagc aggacagctt
     6181 cacgatcccc gtcgggctca gctacacgat cggggagtac agcgccgact tcggggccct
     6241 ggcggcagga ggcgtcgtcg ccgccctgcc ggtggtctgc gtgttcgcag tggtccagcg
     6301 ctatctcgtg cacggcatca gcgccggcgc ggtcaaggga tagcaccccc agagaactgt
     6361 cgagagcagc ctgtcgtacg caggaggaac catgaagatg aaagtggcct gggcggcgct
     6421 cgccgtcctc gccgtcaccg ccaccgggtg cgggtcggac tcgggttccg gcgagggctc
     6481 cggcaagacg accatcacgt tctgggacaa caacgggggc gctcgcaccc cgatctacca
     6541 ggagctgatc aagcggttcg aggcggccaa cccctcgatc cacgtcgagt acgtcggcat
     6601 ccccatcgcc tccgtccagc agaagtacga caccgccatc gcgggcgggg acacccccga
     6661 cgtcggcggc gtcaccacgt cgtacctggc caacctgacc ggccagcagg cgctggagcc
     6721 ggcggacgaa tggctgacca cgagtgcggt gaacggcaag ctggccgcgc cgatgctcga
     6781 ctcggtccgc aagaccgtgc ccgacggcaa gctctacctg gtgccgggca cctccaacat
     6841 ggacgtggtg tggtacctga aggacaagct ccagcaggcg ccgggcacct gggacgagtt
     6901 cttcgccgac gccgacaagc tgaccaagaa gcccgacgcg tacggctaca ccatccgcgg
     6961 cggcgccggc tcgatcttcc agatcctggc cgagatgtac tcctactcgg gcgtgagcga
     7021 gttcttcgac gcgtcgggca agagcacggt caacgacccg aagaacgtcg agttcctcac
     7081 caagatggcc gggctgtaca agaaggacac ccccgaggcc gacgtcacca acgacttccc
     7141 gaagatggtc gccgcgttcg gcaccgggaa gatcgcgatg atgcaccaca acctgggctc
     7201 ctacaacgac cacgtcaagg cgcacggcaa ggacaagatc ggcgccttcg cactgccgac
     7261 cggccccggc ggcaggcgga ccgtcgtcgc caaccccgtg gacggcttcg cggtgttcaa
     7321 gggcagcgag cacaaggacg ccgcctggaa gttcgtggag ttcctggtct cccacgaggg
     7381 caacagctac tggaaccagc agacgggcca gatcccggcc aacaccgagg cgcagggcga
     7441 ctcctggctg cagggccttg agcacctgaa gacggccgtc gacacgctga acgacccgaa
     7501 cacccaggtc gtgtcgccgc cctactacct gccgcagttc tcctccatca ccaaggccga
     7561 caccgagccc ctcttccaga aggtgctgct cggccagatg cagccccagg agttcctcga
     7621 caccctggcg cagaagctga ccgacgccca ggccgagtgg aagaaggcga ccggcggctg
     7681 acgaagccgc ccggcctgcc cccgggaccg ggccggtgcg tccctgaccc cgcaccggcc
     7741 ctcctccgga atcgtcgaga gagggaagag tcatggcggt cgtcgaacgc gtcatcgtca
     7801 cggtcttcac cacggtcacc aggtccgtgg tggacgggca cggccaccgg catcccggcc
     7861 cgccgcggga ggtgcgggag gcgctgctga ccgtcaccga cagcgacggc gcgaccggac
     7921 actgcctggc ggcgccggac accgtcaggg agacggtgat caccggccac atcgggccgg
     7981 cgctgatcgg tcaggacagc ctcgaccggg agcggctgtg gcaccgcgtc gcccgccgtc
     8041 agcggggcgc ccagggcaac ctgtccgacc gcgcgctcag cgcggccgac caggccctgt
     8101 gggatctcgc cgggcgcagg ctcggcctgc cggtctggaa actcctcggc ggcgcccgat
     8161 ccgaggtgcc cgcctacgcg agcacgatgt gcggcgacga catccccggc ggcctggcca
     8221 cccccgagga ctacgccgcc ttcgccaagg aactcgtctc ccggggctat cgcgggatca
     8281 agttgcacac ctggatgccg ccaatgccgt acggcgtgga ccgcgacatc gaggcgtgcg
     8341 ccgcggtccg ggaggcggtc ggcccggacg tcgcgctcat gctcgacagc aaccactggt
     8401 actcccgctc cgaggccctg accctcggca gggccctcga cgagctgaac ttcgcgtggt
     8461 acgaggagcc catggaggag gcctcggtgc agtcgtaccg atggctcgcc gaccagctca
     8521 ggacgccgat cctcgggccg gagacctcct ggggcaagca catggcgcgg gccgagtggg
     8581 tggccgcggg ggcctgtgac atcctcaggg tcggcgtggt cggctccggc ggcatcatcc
     8641 cggcggtcaa ggcggtccac ctggccgagt cgttcggcat ggactgcgag atccacggga
     8701 acggctccgg cgccctcgcc gtgatcggtg ccacgctgtg cgggcagtgg tacgaacggg
     8761 gcctgctgca cccgcactcg gactacgaca cgcccgcccc gcacctgcgc tcgatcgtcg
     8821 acccgctcgc cggcggaaag gtgcggatgc cggacactcc cggactaggg gatgatctgg
     8881 atacggacta catcgcctcc cggacggtcg cctcctgggg aaccggctca caataggagg
     8941 cggacaggcg ggtcagggag gttacaacac atggcggaac ccgtgccgca cgtgaagtcg
     9001 gcactccgga cggtcgagct gctcgacttc ttcgcgcagt atcccggact gcacagcctc
     9061 accgacctac agggcaagct gggctacccc aagagcagcc tgcacgctct gctgcgcacg
     9121 ctggtcgacc tcggctggat cgagaccgac gtcaccggca cgctctaccg gatcggcatg
     9181 cgggctctgc tggtcggggc gacgtacatc gacggcgacc cggtggtcca gctcgcgcac
     9241 gacgcactgg actggctggc cgaggtcacg ggcgagacgg tgcacctcgc ccgtctcgac
     9301 cacttcgaca tcgtgtacct cgccacgcgc gcctcgcggc actacctgcg gccgttctcg
     9361 cgggtgggcc ggcgactgcc cgcgagcacc acgtcgctcg gcaaggcgat cctggcgagc
     9421 agggacgagg gcgaggtgcg cgcgatgctg cccgccgagc tgccctcgct gacggcccac
     9481 acgatcgtgg acgccgagga gctgctcgtc gacctgcacc gggtgcgcaa gcagggctac
     9541 gcggtggacc gcgaggagaa caccgagggg ctgcggtgct tcggcgtcgc gctgcacatc
     9601 agcgacccac cgcgcgacgc catcagctgc tcggtgccga tcccgcgcct cacacccgag
     9661 cgggagaagg agatcgcctc ctgcctcctg gaggcgcgcg agcgcatcga acgctccgcc
     9721 atgcggcagc gccgcgccta ctgacgcgcc cgccgccctg ccgcacccgc cgcgtccaga
     9781 agaaatctag aaatcatccg ggcgcggcga ttctatgggc cgaccggctc ggcggcctgt
     9841 cccgcacatg cataacggtc ggcctctttt cggtcttcgg ctatttcctg cggtgcgaca
     9901 tcgcgcgttc ggcgcatttg tgaacagaca ttgaccgagc gcaattcgaa ttgataagtt
     9961 cccggtgtcg tgatcgtctc ctccggtcgt ggaggtcggc ttgcggttgc cgagagtgaa
    10021 ggccgagcat cggccctacc gattagggca cgacaggatt cgcatcggcg gctccatcta
    10081 cgggatcgcc ggggagatat cggacccgaa cggtcatgca tgggccgcgc tgtccgcgat
    10141 ggacggaacc cgcacgccct ctgacgtcgc cgatcacctg tgcgtattgt ttcccggcct
    10201 gcggagagcg cacgcgaccg gcgtcgtgga cctgctgctg cgatccggct acttcgagga
    10261 cgcggcggcc ccgccgccga gtgatctcag cgcggcggag agggagcgat attctcggaa
    10321 cctcgcgttc ttccgttggg tggacctcgt gccccgggca cacgggtggg aggcgcaggt
    10381 cgcgctgaag cgcgcacgcg tgctggtcct gggactcggc ggcaccggta gccacgccgc
    10441 ctgggcgctg gccgccgcgg gcgtcgggac gatccactgc gtcgaccgtg atgtggtgga
    10501 gctgtcgaac ctcacccgtc aggcgctgtt caccgaggcg gacctcggca aaccgaaggc
    10561 cgacgtggtg gtggaccgcc tcggccgggt caactcgagt gtccacgtga ccggagagac
    10621 ccgggcggtc gagagcgtgg cggatctgtc cgcactgctg accgggttcg acgcgctcgc
    10681 cctgtgcgcg gacgagcctc gcggccggga cggcatccgg atctgggcca accgggcgtg
    10741 cctgacggcc ggggtgccct gggcggtcgg ggggtatcgc ggtcctctcg tcagcgtcgg
    10801 ggtcttcacc gccgacgggc cgtgctacga gtgcctcacc gcgacgatcg aggcgacgac
    10861 cacgcccgga gtccacgtcg acctcggggg gccgggagtg ctggcaccct ccgccggtat
    10921 ttccggtcat ctcaccgcgc aggcggtcat ctcaatgctg gcgggcattc cggcgacact
    10981 gcgcagccac gttaccggaa taaatctggt cgctcccgaa cagcatgtct acatgctcca
    11041 cggagcttct ccggaatgcg ctggctgcgc cacacgacag cgcgggaacc gcgacggcgg
    11101 tattgacgcc taatatgacc cggcctaccg tgaaaagcaa ccgcgacagg aggaggtagg
    11161 aaatggagcg acaggagccg gcggtgcagg agcctgccga gatcgatgac gtggttggaa
    11221 agatatcaat ccggctgctt gacagaatcg agaccacgca aacctacagc gggaactcga
    11281 acagctgacc ggcgatggtc cggacggtcg atcttccgat cgccatccgg gccatcgatt
    11341 tgtgagaatg aatactggtg aggcatgaaa ataccccgac tggaggccgt accgggcacg
    11401 atgctgccca tggaggagta tgcggcggat ttcctggaaa tctttcacga cgtcgacggt
    11461 gtgatctgga aactggagcg cgcccagtcc ttcgacgaag ggacggatcc gagctggaac
    11521 gcgatgcgag agggagactg gcggcggtcc ctggagctgc tggacgaggc ccgtgcagcg
    11581 atcgccgcgg atcttcccgc caagggagaa ctgcggcgcg tgcgggtcgt cgagacgccc
    11641 ctcaccgcgt acctgcagtg ggaacttcac ctcctcgccc tgcgcatgcg cctgggagag
    11701 cgcggcagag tcctggacgc ccgcgaggtg gccgccatcg agatggacgg cccccttccg
    11761 gagctcgtcg tgtttcccgg caggcggatg taccacgttc agtacgagca gggcggcgcg
    11821 tgtcgcggcg cgcggaggat agacgacgac gaagccgtcc gtacgtgggg ttccatcgtg
    11881 tcctccctgt acgaccgcgg tgaagacctg ctggcgtacg tggacaagcg ggtgatgccg
    11941 ctggccccgc cccggatcgg cgtatcagcg cgatgacgcg tgtccggctg cgccccctgg
    12001 gatttcgcga ggacggggac gggtgggtcg tcgggcgggt ggagaccggc gtgtgcatcg
    12061 cggtgcccca tgccgggaag cgtgcgatcg aactgctcga cagcgggcgg acgatccccg
    12121 agacccgcga ggagctcaga accgagctga gggcggagct cgacgtgtcc gcgttcgtgg
    12181 acgacctggc ggccgtgggg atggtggagt cgatcggcga tcgagttttc gccgacaccg
    12241 gaacccctgc gccgtcgctt ccccggataa ccgggcggat ggtgcgatgg acgctgagcc
    12301 cggtgctgca cgccgcactc ggcctgctcg tgttcagcgg attcgtcgcc gcggtgctcc
    12361 ggcctgaggt cgttccccgg tggcgctcct tgctctggag cgaccacggc acactgatcg
    12421 tactgagtga agtcgccctg gtggcggtgc tggtctcact ccacgagctc gcccacctcc
    12481 tcaccgcgcg ggccgcggga gtcccgggac gcatccgggt ggacacacgg cttcagttcc
    12541 tggccgcgca gaccgatgtc tccggcatct ggctcgccga gcggcggatc cgcctgaccg
    12601 tctacctggc ggggatagcg gtggacgcga gcgtcctggc cggctgcctg ctggggacgg
    12661 cactgttcgg cggcaacgtg ctgctgtccg tcatcgctct caccgagatg acagggctgg
    12721 cgttgcagtt cttcgtcttc atgcgcaccg acctgtattt cctggtccag gatctggcgg
    12781 ggtgccgcaa cctctacgcc gacgcgaccg ccttcgtcct gcatctgctt cgccgggtcg
    12841 ctcgggcgtc cacctcggac ccgctcgccg ggctggagcg ccggcaacgc cggttcgtca
    12901 ggctctacag cgccctcctc gtcgccggaa cggggctctg cctcggcgtc tttctcctga
    12961 tctccgtccc cttcaccgtc gcgctgctcg cccggtccat cgacgggctc tcccggcacg
    13021 acgacatgct cggtgtcgtc gacgccctgg tgacgctggg agtcgtcgcc ggctaccagg
    13081 gggtgtgggc gagggcctgg ctccgcaggc acggaccacg ggtgaggcgg ctcgtcgcga
    13141 gactgacgcg cccggctcgc tccgccggct tgcggggtgt ctgcccgcct cgcgactgac
    13201 ctcggcatca cggcttggca tcattccgcg aagaaggaat ccccggcggg ttcccgagac
    13261 ggcgcggtcc agccgggtgc gccaccgccc gccgggggag tcgcggtcag gcgcggttcg
    13321 tgagcggggt cagctgctgg atgtcgtgcc gggcgcgcag cgccgtgatc tctgcctggt
    13381 ccggcggccc cgcggccagc atcctggtga gctcccgcag gtaggtctcg tgacccgccg
    13441 gggtcacgac gaacagcatc cgggccggtt ccgggccggg gttgaagaac gcgtgggggc
    13501 agccggccgg cacgtgcatg aagctcccgg gcccgccccg cagcacctcg gcgccgctgt
    13561 ccgaccgcca ggaccgccag tcggagcccg ccgcggcggc cggatggaag gcgaggaggt
    13621 cgagctcgcc gtcgatgacg tagaacatct cctccgcctc gtgatgcaga tgcgccccga
    13681 cgtcgaaacc gggggcgacc acggcctcga agaccgacca ccccgccgtc tgctccgcgc
    13741 cgaccttcag cgtcatcgcc tgaatcgtgt cgccgcctcc cggcggcagc agcagtccgt
    13801 cggtcatgtc cttgaccctc acgctttcca gccggtggcg cgcagccacg tttccaaggt
    13861 catcaggccc gggtgctcgg ggcgcagggc ccgcagatcg acctgtgcgg gcggttgctc
    13921 ctcgaagaac tcgaacatcc gggccaccca ctcgtcgaac gcgcgcacct gctcgatggg
    13981 cgtccgttcg aagcgggccg gcaggccgca cacccggccg aacgtggcgg cgatctcagg
    14041 cggggtgagc tcgtcgccgc ccaggtcgac cgtacggccg aggaagcgtc cggggcgctc
    14101 gaaggcgagg gcggcgaaca ccccgatgtc ctcgacgccg atcagctgca tcggggtgcc
    14161 gggctgcgcg gggagccgca cgaccagcgt gccgtcctcc aggaccggcc ggttgtaggt
    14221 ggtgaagttc tccatgaagg agaccgggcg caggatcgtc gccggcagcc cgagcgcgtg
    14281 gatctcgcgc tcgatccgtg ccttgctctc gatgtggggg attccggaag ggtggtccgt
    14341 gccggggacc gagctgtaca ccaggtggcc cgtgccgatc tcggccgcca gccgggccac
    14401 cgtcaggccc cgccgctcct cggcggcggc gccctcgacg gtgatcttcg ggccctgcat
    14461 catggtcagc gccaggaaga ccccgtccac gccccccatc gcgcggcgca gcgacccctc
    14521 gtcgtcgagg tcgcccacgg cgagttccgc ccccgactcc tccagggccc tcgcggcgga
    14581 accgcccggg tcgcgcacca gggcgcgtac gctccggccc cgggcgagca gtcggcgcgc
    14641 ggtcgcgccg ccctgctggc ccgttgcgcc gaccactagt acgggatcgc tcatggcgcc
    14701 tacctccgtg gcagactcgc ggtgtgatgg atcatggacg tcacgataac gagacggcgt
    14761 ccggcggtcc tggcactcgt gctgccagta acgcgcccgg ccgccgcgcc agggcgtcgg
    14821 gccgcagggc cgagctcggc gcgttcctcc gcgcccggcg ggcccgcctg catccggccg
    14881 acgtcggcct gccggaaggc gatccggccc tgcgccgcac ccccggcctg cgccgcgagg
    14941 agatcgccga gctctcgggt gtcggcgtca cctggtacac ctacctggaa cagggacggg
    15001 acatctcggc gtcggcgcag gtgatcgacg cgctggcccg tgcgctgctg ctcgatcccg
    15061 acgaacaccg ccacctgcgc gacctggccg gactggcccc accggacacg ccggagacgc
    15121 cgtccggcga ggcggagcgg ccgcgggacc ggctgcggcg cctggtggac gccgccgccc
    15181 cgaacgccgc ctccgtgtac gacgcgcgct tcgactatct ggcctggaac accccttaca
    15241 ccctgctccg ccacgatccg ctgacgctcc cgccgggcag gcggaacctg ctgtggatga
    15301 tgttcaccga cgccggcaac cgtgcccgga tggtccgttg ggaacccgcc gcccgcgccc
    15361 tgatcagcca gttccgcgcc gcgatgggac accggcaggg ggaccccgcc ttcacggcgc
    15421 tggtggcgga gctgagcgag gccagcccgg agttccggga gtggtgggcg gactacccgg
    15481 tccgccggtt caggcccgcg acggtcgcga tcgaccaccc ggagatcggg cggctggatc
    15541 tggagatgtt ccagctgcgc ccggcggagc accccgatct cctgctggtg ctgcaggtgc
    15601 cggcggacga ggacggtcgc aggcgggtga ccgcgctcct cgacgggcgg agcgccccag
    15661 acggcgatcc cggcggcgcc ccggacggca gcgcctcgca gggcggcctt ccggcgcgcc
    15721 gccccggtaa tcgctcgcat ccggggtaac ttcggcatca tggccacccg tacgtccgga
    15781 caggggtccg gcaagcgccc cgcctcgcgc tccggatccc gtacggcttc cgcgaagcga
    15841 tcccctgcgg gctcccgagg cagggcggcg ccccggcccg cgcccaagcg gccggtcgcc
    15901 accggacagg acccgatcag ctggttcttc ctcgtgatcg gcaagctcgt catcggcatg
    15961 tggatgctgg tggcgaacgg cgtgggcatg gcggcgcggg cgctcgggca gggagcccgc
    16021 gacctcgacc ccgcgcaccg ccgcgacggg caggggctgt cggtgctcgc gggcgccatc
    16081 gtgctcgccg ccctgacctg gcgggaaacc aagacgggat tcgccgagtt cgtcgacgcc
    16141 gtggtgcgcg ggacggtggg atcgctcgcc tgggcggtgc ccgtgctgct cgcgctgctc
    16201 gcctggcggc tgctgcgcca ccccgaccag aacgccgaga ccggcaggat gggcatcggc
    16261 tggaccgcgc tgctggccgg gatcctcggg atcgtgcacg tcgcccacgg cacgccgtac
    16321 ccctccgggg ggcccaacga cggcatggac aacgtgtcgg cggcgggcgg catgatcggc
    16381 ttcatcgtct cggctccgcc gtcgagcatc ctgccggcgt tcatcacgat cccgctgctg
    16441 gtgatgctgt ccggcttcgg cctgctggtg atcaccgcga ctccggtcca ccgcgtcccc
    16501 gagcgcctcg ccgagatcca gcacatgctc ttccaccggc cggaggagac cggggagccc
    16561 cgcaagaccc ccgcaccggc caggaggcgc acgcgcaagc agcagggcgg caggcgcgac
    16621 gccgagggcg gcgacggcgt caagccgtac gacacgcccg tgctgtcgga caaggagcac
    16681 tcgccggaga tcgtccccgg cctcatggac gacgccgcgg agtcggccga gccgaccgag
    16741 ccggagatac ccaagccggt gcctcagcct ccgctgccga cccccgcgcc gcgcaaggtg
    16801 gagcagctcg tcctgtccag ccaggagggg ccgtacacgc tgccggacct cacgacgctg
    16861 cgcccgggca gcgcgcccaa gcaggagacc aaggccaacc ggacggtcgt gaacgcgctg
    16921 accagcgtgc tggagcagtt cgccatcgac gcgcaggtgg tcggcttcac ccggggcccg
    16981 acggtgacca ggtacgagat cgagctgggc ccggccgtca aggtggagaa ggtcaccgcg
    17041 ctcaccaaga acatcgccta cgccgtcaag tccgcggacg tccggatcct gtctcccatc
    17101 cccggcaagt cggcgatcgg cgtggagatc cccaacgtcg acaaggacct cgtgtcgctc
    17161 ggcgacgtgc tgcgctcgcg ggtggcccag gccgaccacc acccgatgat cgtcgggctc
    17221 ggcaaggacg tcgagggccg caccatcgtg gccaacctgg ccaagatgcc gcacatcctc
    17281 atcgcgggcg ccaccggcgc gggcaagtcg acctgcatca acgggctgat ctcttcgatc
    17341 cttctgcggg ccacgcccga cgaggtccgc atggtgctgg tcgaccccaa gcgggtcgag
    17401 ctcacctcgt acgagggcat cccgcacctc atcacgccca tcatcaccaa cccgaagaag
    17461 gccgccgagg ccctcgaatg ggtggtgggc gagatggacc ggcggtacga cgacctggcg
    17521 gccagcggct tccggcacgt ggacgacttc aacaaggccg tgcgcgcggg caagctggtg
    17581 ccgccgccgg gcagcgagcg cgtctaccag ccgtacccgt acctgctggt gatcgtggac
    17641 gagctggccg acctgatgat ggtcgcgccg cgtgacgtgg aggactcgat cgtccgcatc
    17701 acacagctcg cccgggccgc cggcatccac ctggtcatcg ccacccagcg gccgtccgtg
    17761 gacgtcgtca ccggtctgat caaggcgaac gtgccctcgc ggctggcgtt cgccacatcc
    17821 tcgctggccg actcgcgggt catcctcgac cagccgggag ccgagaagct cgtcgggcag
    17881 ggcgacgcgc tgttcctgcc catgggcgcg agcaagccga tgcggctgca gaacgcgttc
    17941 gtctccgaga aggagatcgc ggacatcgtc gcccactgca aggcccagat gcaggccgag
    18001 tatcgggagg acgtcgccgc gcccgccgcc gccaagcggg aggtcgacga ggagatcggc
    18061 gacgacctcg acctgctgat ccaggccacc gagctgatcg tgtcgaccca gttcggctcc
    18121 acgtccatgc tccagcgcaa gctgcgcgtg ggcttcgcca aggccggccg gctgatggac
    18181 ctgctggaga gccgcaacgt ggtcggccct agcgaggggt ccaaggcccg cgaggtgctc
    18241 gccaagcccg acgacctgcc cggcctgctc gccgagatgc gcggggagac cggctgagag
    18301 cccgtcgctc acgacgcgtg ccggtcggcg gccgcgtccc tctcgtcttg ccctgaaacc
    18361 gttgcggaag tgacaggaga gttgctccgc gtccacccct gggtaccctc cgtagtcagt
    18421 tactgattga atgtgactaa ctacgcatcg tggggcgagc tggaagacgg tgcggttgga
    18481 gacagggggg cggaacgatg agcgttggtg ctgttttggc cgaagcccgt gagcgcgccg
    18541 gactgaccgt gcgtcagctc agcgagcgca cgcgggtgcg tgagaccgtc atcgaacgct
    18601 tcgagcgcga cgacttctcg gtgggggact tctacgcgcg ggggcacatc cggaccatcg
    18661 cctccgacct cggtctggac ccggacgaga tcctgcggca gtacgagcag gagaacgccg
    18721 acatcgcgtc accggtcaag gcgtcggcgg tgttcagggg cgacgtgggg gagcgggccc
    18781 gcagggtccc caactggacg atggccgtcg cggtggccct ggccatcgtc gcggtcgtcg
    18841 tcatcgcgcg gatgctcggg ggctccggcg ggaagacggg cccgacggcc gcccagctcc
    18901 cggtgacggc gccgcacgcg cgtcacgaca agggccacga gaagaagacc gtcgaggagg
    18961 ccctcgcgcc cggcgtcgtg gtggtgaagg tcaccgcgcg caagcagtcc tacctcagcg
    19021 tcaaggacgc caagggcaag gagatctttc agggaacgct gcccgagggc aagaccacga
    19081 cctattcggc caaggaccgg atgaaggtga ccatcggcga cgcgggggcg gtgcggctgg
    19141 aggtcaacgg aagggacctc ggcacgcccg gcaaggacgg ccagatgatc cgccggacct
    19201 tcgacgcggg tggcccgagt ccccgttaat cgccgactgc cgataccgta gttcgcatca
    19261 tgtcttctcg ccgaaccgta tcgctgatca cgctgggctg cgcccgcaac gaggtcgact
    19321 ccgaggagct ggccgcgcgg ctggaggccg ccggctggca caccgatgac gacgatcccg
    19381 acgtcgtcgt cgtcaacacg tgtggcttca tcgattcggc gaagaaggac tccatcgaca
    19441 ccctgctcgc cgcggccgac tcgggcgcga aggtggtggc ggcgggctgc atggccgaac
    19501 ggtacggcgc gcagctcgcc ggcgccctgc ccgaggcgac cgtgatctcc ttcgacgact
    19561 acgccgcgat cggggagcgt ctcgacgacg tcctcgcggg caggccgctg gtcccgcact
    19621 cgccgcggga ccgccgcacg ctcctgccga tcacgccggt ggagcgcgcg gccgcccggg
    19681 cccacattcc cggtcacgcc caggaggacc cgctgccgga gggcgtcgcc cccgccagcg
    19741 gcccgcgcac gctgcgcaag cggctcggct cggggccggt ggcctcgatg aagctcgcgt
    19801 ccggctgcga ccggcgctgc acgttctgcg cgatcccggc cttccgcggc tcgtacgtct
    19861 cgcgccgccc ggaggacctg ctcgccgagg ccgcctggct ggccggacag ggcgtcaggg
    19921 agctcgtgct ggtcagcgag aactccacgt cgtacggcaa ggacctgggc gacctgcgcg
    19981 cgctggagaa gctgctgccc ccgctcgccg cgaccgaggg catcgagcgg gtgcgggtca
    20041 gctacctgca gcccgccgag ctgcggcccg ggctgctcga cgtgatcgcc tccactgagg
    20101 gggtcgtgcc ctacttcgac ctgtccttcc agcacgccag cgggaccgtg ctgcggcgga
    20161 tgcggcgctt cggcgacccc aagcggttcc tcgacctgct cgcgcagatc cgcgaccgcg
    20221 cgcccgaggc gggcgtcagg tccaacttca tcgtcggatt cccgggggag acccaggagg
    20281 agttcgacga gctggtgggc ttcctggagg aggccaggct ggacgtcatc ggcgtcttcg
    20341 gctactccga cgaggagggc accgacgcgt acggcttcga gggcaagctc ggtcaggacg
    20401 tgatcgacga gcgggtcgcg acgctgaccg agctcgccga ggagctgacc gctcagcggg
    20461 ccgaggagcg catcggcacc gagctggagg tcctgatcga ggaggacctc ggggacggcg
    20521 gatacgaggg ccgggcggcc caccagggcc ccgaggtgga cggtgcggtc acggtccagg
    20581 ggatcgggct ggttcccggc cagatcgtcc aagcggtcgc cgtcgactcc gagggggtcg
    20641 acctcatcgc ccggatcaag gcaggcacat gacggagcgc ggtgagccgc cggtggacgt
    20701 ggcgggcccg ggagaggtga caccggagcc cgcggcgccg ccggtcgccg ccgtgcccgc
    20761 cgcggacggc accggagacg gcgctatccg tcacgtcagc acctggaaca tcgcgaacgt
    20821 cctgaccatc gcccggctgg cgatcgtccc cgtcttcatc gtcttcctgt tcgtcgaggg
    20881 ggagggctgg cgcctggcgg ccctcggcgt cttcctgctc gcgtccctca ccgaccagct
    20941 cgacggctgg ctcgccagga agtacgcgct ggtcaccgac ttcggcaaga tcgccgatcc
    21001 gatcgcggac aaggcgctga tcggcgccgc gctgctcagc ctttcctacc tcggtgaggt
    21061 cccgtggtgg gtcaccgtgg tgatcatcgc ccgtgaggcg ggggtgacgc tgc
//
