LOCUS       NZ_BMMN01000006        24990 bp    DNA     linear   CON 22-DEC-2024
DEFINITION  Microbispora bryophytorum strain CGMCC 4.7138 sequence06, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMN01000006
VERSION     NZ_BMMN01000006.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Microbispora bryophytorum
  ORGANISM  Microbispora bryophytorum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 455402)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 202X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645855.1-RS_2024_12_22
            Annotation Date                   :: 12/22/2024 07:39:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,203
            CDSs (total)                      :: 7,136
            Genes (coding)                    :: 7,048
            CDSs (with protein)               :: 7,048
            Genes (RNA)                       :: 67
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1, 2 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 88
            CDSs (without protein)            :: 88
            Pseudo Genes (ambiguous residues) :: 0 of 88
            Pseudo Genes (frameshifted)       :: 16 of 88
            Pseudo Genes (incomplete)         :: 78 of 88
            Pseudo Genes (internal stop)      :: 7 of 88
            Pseudo Genes (multiple problems)  :: 11 of 88
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:18:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 286281
            Orig. end                         :: 311271
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMN01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24990
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24990
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24990
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14990](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14990
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            605..1318
                     /locus_tag="IEY80_RS19095"
                     /old_locus_tag="GCM10011574_38640"
     CDS             605..1318
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543831.1"
                     /locus_tag="IEY80_RS19095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38640"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_229689727.1"
                     /transl_table=11
                     /translation="MYAASGVLAVCTERGTSIVPANRVAWTPAGFTHYHRAHGDTDMRI
                     VFLPPSLARLVPEHPVVFLASNLAREVLLALTGPRNYDDALVYSRSARLRLLRVLVDEL
                     REAHEQPLHLPEPRDDRLRAVARLLYENPADNASLAELGKTIGASTRTLSRLFRDELGM
                     TFYEWRTQLRVHHALVLLADGHDTTRTAYACGWANPSSFITAFTDIIGTTPGRYRTGRE
                     TTIPARLKSMIRDVE"
     misc_feature    1466..1482
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.06"
                     /tool="antismash"
     misc_feature    1482..1496
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(1484..1495)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.57"
                     /tool="antismash"
     gene            1522..1950
                     /locus_tag="IEY80_RS19100"
                     /old_locus_tag="GCM10011574_38650"
     CDS             1522..1950
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012762.5"
                     /locus_tag="IEY80_RS19100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38650"
                     /product="cellulose binding domain-containing protein"
                     /protein_id="WP_142572262.1"
                     /transl_table=11
                     /translation="MRFLRASLGIGIAAILLAASFTGPAQAAPVDVPAGYDCAVTYASV
                     GWTTGFTTRLTITNTGTLVFGPWILQFVFPGGQTLMQGWNATFSETPPSVQAANPIWQP
                     SIDPGTSFWIGFNANGADEHPTGFTLNGVPCAVTYGPY"
     gene            complement(2122..3249)
                     /locus_tag="IEY80_RS19105"
                     /old_locus_tag="GCM10011574_38660"
     CDS             complement(2122..3249)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542106.1"
                     /locus_tag="IEY80_RS19105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38660"
                     /product="thiolase C-terminal domain-containing protein"
                     /protein_id="WP_142572261.1"
                     /transl_table=11
                     /translation="MNIVIAGAAETDELGKLPHMSTAQLHLQAARNALADAGMTKDDID
                     GVATVGVPGPIQIAHALGIAPAWLDGTGVGGSSFLFHVRHAAAAIRAGLCTTVLITHGE
                     SGRSRVGAPRPALGPDSLIGQFEMPYGVLGPPTMFTLTALRYMKETGLTHEQLAEVAVA
                     QRRWAHRNPRAMFQDLITVEDVLASRMVAYPFHLLECCLVTDGGGALIVTTEERARRSP
                     VHLLGSGESAESPIISQMEDFTTSAAFRRSGEAAFAEAGISHDDVDHLMIYDAFAHVPI
                     YGLEDLGFVKRGEAGPFIAEGHTSPGGRLPLNTNGGGLSYTHTGMYGMFAIQESVRQLR
                     GEAAAQVPGVEVGVVLGNGGMFASAATLVLSNRRP"
     gene            complement(3246..3689)
                     /locus_tag="IEY80_RS19110"
                     /old_locus_tag="GCM10011574_38670"
     CDS             complement(3246..3689)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542105.1"
                     /locus_tag="IEY80_RS19110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38670"
                     /product="Zn-ribbon domain-containing OB-fold protein"
                     /protein_id="WP_142572260.1"
                     /transl_table=11
                     /translation="MTASHKPVPKPTPETQPFWDGTAEGRLRIQRCDACSRHFFYPRPA
                     CPHCGSDDVTWVTAGGRATLYSYVISHRPAPGFEQDGPYAIAVVELEEGVRMMTNIVGV
                     EITPENLPLDMELRVVFEQRGDVHVPLFTPASAVDDAPTGAAA"
     gene            complement(3766..4278)
                     /locus_tag="IEY80_RS19115"
                     /old_locus_tag="GCM10011574_38680"
     CDS             complement(3766..4278)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025050.5"
                     /locus_tag="IEY80_RS19115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38680"
                     /product="VOC family protein"
                     /protein_id="WP_142572259.1"
                     /transl_table=11
                     /translation="MDIAEELAGLDAAFDHTAVAAPRIRDLLPLYRGLLGGAYLGGGDN
                     VVNGYRTLQLRYANGSKIELMEPLAGSSFFDSFFDLTRGRGGVHHLNFHVTDIEAAVDA
                     LRGRGYRLFGLNLAEPRWREVFLHPKEAHGVLVQLAQPGPRATEPVPSLDDLLAGRGRR
                     GNGVPSP"
     misc_feature    complement(4385..4399)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.22"
                     /tool="antismash"
     gene            4455..5777
                     /locus_tag="IEY80_RS19120"
                     /old_locus_tag="GCM10011574_38690"
     CDS             4455..5777
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="IEY80_RS19120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38690"
                     /product="MFS transporter"
                     /protein_id="WP_142572258.1"
                     /transl_table=11
                     /translation="MGLSYVRELDEYPTGARRMKILTMAVLAVLIGSYEAQIAPVVPLL
                     LKDLDMSLATYGAVSGAAAVAGALASALGGRLTDRIGRVRLLVPLMLLTAVCCFGMTLV
                     HSPRDLLIARIALAFVDGVAMASTAPLVRDFSPRLGRAQAFGFWTWGPVGANFLAAAVA
                     GWTLPIFDDSWRSQFVIMGCFSLVISIVIAFNIADLSPELRAQIQHTERKAADVVDLTR
                     PARVSSLFVRPNIWAHVVGISLWLVLYITLTLFGQTMLVGALGITTAEASTIMACFWSL
                     NLITLIVAGRVSDRTQLRKPITLVGTVAAVVVTAYLAYILGGEGVSSGMLMIVGALLGG
                     SLGVAYAPWMANYSEDAEDVDPRLQGTAWGLFGFLTKAIAVVGLLVIPHVVEATSWQTW
                     LVVSLVCLALFAPAVFLFHGPWRREHAVTAEDQEARVAVAE"
     gene            complement(5794..6429)
                     /locus_tag="IEY80_RS19125"
                     /old_locus_tag="GCM10011574_38700"
     CDS             complement(5794..6429)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037625.5"
                     /locus_tag="IEY80_RS19125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38700"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_142572257.1"
                     /transl_table=11
                     /translation="MSAGGLRELKKNRTRQLIADTANALFRARGFDEVTVDEIAAAAQV
                     SKKTVFNHFPTKEDLVFYRAEDREAMSLAAVTDRPAGFSILDSFRALCLAQTRFIPGMR
                     RDLVHPRSFFDLVSGNPSLERKMHEVNERIIRVLADALAAEAGAEPGDPLPRIVASTLV
                     GAQRALYRRLRQRVREGGSDEEIGRAHRADVERVFGLLGNGLGGYPPV"
     gene            6504..7490
                     /locus_tag="IEY80_RS19130"
                     /old_locus_tag="GCM10011574_38710"
     CDS             6504..7490
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852755.1"
                     /locus_tag="IEY80_RS19130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38710"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_142572256.1"
                     /transl_table=11
                     /translation="MTHPAVHTTGLAKHYGDVEAVRGIDLTVRKGEIFGFLGPNGAGKS
                     TTISMLCTLTTPTSGEARVAGHDVVRERDSVRRSIGLVFQDPTLDGYLTAERNLRFHAE
                     LYGVPRADVGPRLRGVLEMVGLWDRRDARVATFSGGMRRRLEIARGLLHSPRVLFLDEP
                     TVGLDPQTRSSIWSYIRELKDAEDITVFLTTHYMDEAEHCDRIAIMDGGQIIALDTPAA
                     LKAGVGKDRVQIETDDGAAAVAALDDRFGIQAVASGGVVVFHVDEGERFVPELFSRSGL
                     PIRSVSVARPSLDDVFMSYTGRSIRDAESTGGARGPAALAAARGGRR"
     gene            7487..8341
                     /locus_tag="IEY80_RS19135"
                     /old_locus_tag="GCM10011574_38720"
     CDS             7487..8341
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132401.1"
                     /locus_tag="IEY80_RS19135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38720"
                     /product="ABC transporter permease"
                     /protein_id="WP_142572255.1"
                     /transl_table=11
                     /translation="MTLPITAVRVPGRSATSELRAVKVVWQREIIRFFNGPLRILTSLV
                     QPFLFLFVLGTGLSQLTSGGTGGLGLRTFLYPGILAMAVLFTAMSSAASIVWDREFGFL
                     REMLVAPVSRGSIVLGKCLGGATVASFQGLVVICIAGPVGVPYAPGLMLGVFGIQVLLA
                     FTITAFGVAMSVRVKQMQSFMALNQLLIMPLYFMSGAMFPASNLPAWLTALNRIDPLSY
                     AVDPIRRLVFAHLNLTPAVRARLAPGLTWGGWHVPILVEVAVLAVLGLALLATAIAQFG
                     RAD"
     gene            8677..9888
                     /locus_tag="IEY80_RS19140"
                     /old_locus_tag="GCM10011574_38730"
     CDS             8677..9888
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) Chlor_Efflux_Pump"
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891893.1"
                     /locus_tag="IEY80_RS19140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38730"
                     /product="Cmx/CmrA family chloramphenicol efflux MFS
                     transporter"
                     /protein_id="WP_142572254.1"
                     /transl_table=11
                     /translation="MPLPLYSLALAVFAMGTSEFMLAGLLPDIASDLGVTVGTAGTLTS
                     AFAIGMIVGAPLMAGLARDRSPRSGLLGFVLVFVAAHVAGAAASGFPVLFAARIVAALA
                     NAGFLAVAVSTAAALVPENRKGRAVAVLLSGTTVATVAGVPGGAVLGTLLGWRVTFWAV
                     AVLCVPAAVGILRGIPARSAQAGEADGRVLRSELAQLGNRRLILVMLLGALVNAATFAS
                     FTFLAPIVTGTAGLDPLWIPVVLVLFGVGSFVGVAIAGRLSDRHPGLVLAIGGPLLLIG
                     WPALAVTAGEPVVLLILVFVQGALSFALGSTLITRVLYEAAGAPTMAGSYATAALNVGA
                     AAGPLLAAATLGTAALGKGAADLGPLWVSALLVAIALLIGLPSGVVRRHGPRERGAEQR
                     TEPN"
     gene            10001..11113
                     /locus_tag="IEY80_RS19145"
                     /old_locus_tag="GCM10011574_38740"
     CDS             10001..11113
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.5"
                     /locus_tag="IEY80_RS19145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38740"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_142572253.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.5e-50, bitscore:
                     165.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADTVDTSIKGTTGIGDDGGIAAVTSAVRGRVDELLAGFLDARR
                     PPVGDPDVAEGYRLLREFVVEGGKRIRPLLCYWGWRGAGGEEPHEERAVITGAALELYH
                     AGLLIHDDVMDGSELRRGRPTIHRGLAGAPRWTGAETFGQSAAILLGVLAQAWADELLA
                     DAVAADSRGRAARELFNRMRTEVVTGQYLDILAHARADADVERALTVIRYKTARYTVER
                     PLQIGAALAGAPPALLDAYSRFGLPLGEAFQLRDDVLGVFGDPAVTGKPVLDDLREGKR
                     TVLMAYAFARARGPERDRLRTWHGAPDLDERRAAELRQIIVDTGALGEVEGLIALRAVQ
                     ALDALRDCAIAPEAARALAVLTERLTRRVR"
     gene            11416..12789
                     /locus_tag="IEY80_RS19150"
                     /old_locus_tag="GCM10011574_38750"
     CDS             11416..12789
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658245.1"
                     /locus_tag="IEY80_RS19150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38750"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_142572326.1"
                     /transl_table=11
                     /translation="MPTDNRLSLSTRAARNLATTTKTPPQMQEITSRHLLRVLPWVEAV
                     GGAYRVNRRLTYQMADGRLTFVSTGADVRVISAELCELPALRGFADADVLAALADLFTQ
                     REYEAGQVIERAGTPMDEVLLLAHGKVDRLGEGEYGNETRLGVLADGEYVGEHMLVNAD
                     ARWEWTVKAVTACTVLALGREEFERLLTLSDGLREHVQAYREDPDRPVNRFGEAEIALA
                     AGHVGEATLPGTFVDYELGPREYELSVAQTILRVHSRVADLYNEPMNQTEQQLRLTIEA
                     LRERQEHELVNNRDFGLLHNADLKQRLHTRSGPPTPDDLDELLATVWKNPNVMFAHPKA
                     IAAFARQCNARGIYPQTVEFNGQKAPAWRGVPMLPCNKIPVNDKGISSIMVMRLGEKDQ
                     GVVGLRRTGLVDEYEPGLSVRFMSIDEKAILSYLVTTYYSAAVLVPDALGILESVEVL"
     gene            12789..14990
                     /locus_tag="IEY80_RS19155"
                     /old_locus_tag="GCM10011574_38760"
     CDS             12789..14990
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017574408.1"
                     /locus_tag="IEY80_RS19155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38760"
                     /product="terpene synthase family protein"
                     /protein_id="WP_208762284.1"
                     /sec_met_domain="T1TS (E-value: 9.2e-81, bitscore: 267.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSYRLPDFYLPYPPRLNPHVETARAHTRGWAADMGMLDDPDIWT
                     EESLDAMDYGLMCAYTHPDCSATELDLVTDWYVWVFYFDDHFLETFKRSRDLDGAQDYL
                     DRLDAFMADDPPEPTNPVERGLADLWPRTVPAMSQAWRRRFVRVTRDLLQESMWELFHI
                     EREAVSNPIEYIEERRKVGGAPWSAALVEHAAGAELPARLADSRPIRVLTESFADAVHL
                     RNDLFSYEREVLREGELSNCVLVSERFFGCDTERAVEITNDLLTSRLHQFEHTALTELP
                     ALFADEGVLPPEQALVLSYVKGLQDWQAGGHAWHTASSRYTKTAGQAGFFGMNVARAHL
                     TGAGGLRNHTHRPFAEAAVRLPQPYMPFEVRDNPHLDAARAADVEWCAEIGFFDGVPGI
                     PATAVWNEPQLVGFDLALCASGINPDATADELILATNWLAWGTYGDDYYPRVYGVARDL
                     IGAKLGNRRLKEFMPLDLVPRLTPMTGLERGLADLWPRTAGPLPEGSRRAFRVAVEEMI
                     DSWVWELANQAQHRVPDPVDYIEMRRRTFGSQMTMSLARLAPGRVIPDEIHRTREFLGM
                     TDAAQDYACLLNDLFSYQKETQFEGELHNAVVVLGTFLDCAPGEAVTVVDALMTSRMRQ
                     FEHITTVDLPALLDRIEVGEAVRESVGGYVADLRNWMAAILRWHQRSRRYCEEELRRGP
                     AARWSQGPTGLGTATARFLPLAPPASPASLAHALPVGAP"
     gene            14987..16318
                     /locus_tag="IEY80_RS19160"
                     /old_locus_tag="GCM10011574_38770"
     CDS             14987..16318
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658244.1"
                     /locus_tag="IEY80_RS19160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38770"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_142572251.1"
                     /transl_table=11
                     /translation="MTESRLTLSTAAARNLATTTKTPPQMREITPRHLLRVLPWTEVQG
                     GVYRVNRRLTCTVGDGRVSFVSTGARVRVIPAELCELPSLHDYGDLDTLRALADRFVQH
                     DLSSGEPVPPGQVVLVAHGKVARVGAGAYGGEALLQVLADGDHLGDLTGPGAPPAKAVT
                     SCIVLVLDRSVLDNLTALAGGLREHLGRPAEARPVNRFGEAEIALAAGHVGEATLPGTF
                     VDYELGPREYELSVAQTILRVHSRVADLYNEPMNQTEQQLRLTIEALRERQEHELVNNR
                     DFGLLHNADLKQRLHTRSGPPTPDDLDELLARRRSSHYFLAHPRAIAAFGRQCTRRRVY
                     PDVTEVNGATVMAWRGVPILPCDKIPISEGGLSSILVMRTGADKQGVVGLRRTGLPDEY
                     EPGLSVRFMSVDEKAILSYLVTTYYSAAVLVPDALGILESVEVN"
     gene            complement(16376..17140)
                     /locus_tag="IEY80_RS19165"
                     /old_locus_tag="GCM10011574_38780"
     CDS             complement(16376..17140)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (12-168). E-value: 1.9e-09.
                     Score: 29.6. Matches aSDomain:
                     nrpspksdomains_IEY80_RS19165_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017627041.1"
                     /locus_tag="IEY80_RS19165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38780"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_223854085.1"
                     /sec_met_domain="adh_short (E-value: 5.9e-33, bitscore:
                     109.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.4e-36, bitscore:
                     121.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGQPTGRFAGRIVVVTGAGSGIGRATALAFAQAGAQVLGVGRRA
                     QALEETARQHPRIAALAADVRVAGSPETIVRTAVDRWGRLDVLVNNAGATTVMPLAETT
                     AARVTDLFDLNVTAPSLLARAALPHLRETGGSIVNVSSTFGHRPLPGAAHYAASKAAIE
                     QLTRSWAVELAGDGIRVNALAPGPTESEALTAAGLPEAVVEQTKQDEARRIPLGRRGEP
                     REVAEWILHLADPAATWLTGQVLTLDGGLELT"
     aSDomain        complement(16637..17104)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY80_RS19165_PKS_KR.1"
                     /evalue="1.90E-09"
                     /label="IEY80_RS19165_PKS_KR.1"
                     /locus_tag="IEY80_RS19165"
                     /protein_end="168"
                     /protein_start="12"
                     /score="29.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="IVVVTGAGSGIGRATALAFAQAGAQVLGVGRRAQALEETARQHPR
                     IAALAADVRVAGSPETIVRTAVDRWGRLDVLVNNAGATTVMPLAETTAARVTDLFDLNV
                     TAPSLLARAALPHLRETGGSIVNVSSTFGHRPLPGAAHYAASKAAIEQLTRS"
     CDS_motif       complement(17030..17098)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY80_RS19165_0001"
                     /evalue="8.40E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IEY80_RS19165"
                     /protein_end="37"
                     /protein_start="14"
                     /score="12.0"
                     /tool="antismash"
                     /translation="VVTGAGSGIGRATALAFAQAGAQ"
     misc_feature    17125..17140
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    17168..17188
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            17195..17539
                     /locus_tag="IEY80_RS19170"
                     /old_locus_tag="GCM10011574_38790"
     CDS             17195..17539
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017597672.1"
                     /locus_tag="IEY80_RS19170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38790"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_142572249.1"
                     /transl_table=11
                     /translation="MKRAHHPQLDEISLTAVMAALSDPIRVGLVRLLADGREHGWGELR
                     APVAKSTLSHHLKVLRDAGITRTRQEGTRCFVVLRRDDLETRFPGLLAPVLAAAECDGV
                     GRQVGLAASA"
     gene            17624..18421
                     /locus_tag="IEY80_RS19175"
                     /old_locus_tag="GCM10011574_38800"
     CDS             17624..18421
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013757.5"
                     /locus_tag="IEY80_RS19175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38800"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_142572248.1"
                     /transl_table=11
                     /translation="MRLFVPLDRARRAEAASALGSLERGMEILLCLAAGMRPMNLTQVH
                     RSTGFSKTTTHRLLGSLQRRGLVTRTGGDYTVGGRLADLVPPRGWAVQGRRLPGSRRVV
                     LPHLLQLYEATRQTVNLAVRDEFEVAYVERLYGHNRVTSPSDGVDRAPLHCTATGKVLL
                     AYDAGLRAAFLAAPALRRMTGRTVTRPAALERELAAIRGEGVGYARQEFAEGVCCAAAP
                     VFGPDGGVCMAVAVAAPVGAAALPRMGAAVRRTAHQITGALLM"
     gene            18548..19105
                     /locus_tag="IEY80_RS19180"
                     /old_locus_tag="GCM10011574_38810"
     CDS             18548..19105
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS19180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_38810"
                     /product="hypothetical protein"
                     /protein_id="WP_142572247.1"
                     /transl_table=11
                     /translation="MRRGQYASRLIGWVGLVALPVIVLLAACGTPEPQMRPRPVATDGS
                     ASPGGLVSTGDPVSTAVPASPSPGPSAVSAADHPEACRNAACEVAVRPGDRLRLDRKTG
                     LDAITIVSLDQGELRLRFKAGAGAFRVEGMNTGVSQSCVNGRCRTEGGLTLAPGRPGRI
                     GDIRLRLASVAPGYAVLVLSPA"
     gene            19334..20188
                     /locus_tag="IEY80_RS19185"
                     /old_locus_tag="GCM10011574_38820"
     CDS             19334..20188
                     /EC_number="2.8.2.-"
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050656 - 3'-phosphoadenosine
                     5'-phosphosulfate binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_3: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895577.1"
                     /locus_tag="IEY80_RS19185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38820"
                     /product="sulfotransferase"
                     /protein_id="WP_142572246.1"
                     /transl_table=11
                     /translation="MAWKSRVNAAVEGMTGYVITRARPRAVPAAEPRDEPRPPADPAAD
                     RLLRAPVFVLSPVRSGSTLLRVLLNSHSRIHAPHELHVRRIAVTLTTDPVRQAMEAAGH
                     RTSDIEHILWDRLLHRELVRSGKEVIVDKTPSNVFACRRITTCWPDARFVFLLRHPASI
                     ARSWHEADPRARPMDEAVRHTLQYMRHLEDARRRHDGIDVRYERLVDDTEGELRRLCAW
                     LGVEYEPGMVRYGDKDHGDFVKGIGDWRDKIRSGRVQPGRPLPAPEEVPGALREIAAAW
                     GYL"
     gene            complement(20196..20393)
                     /locus_tag="IEY80_RS19190"
                     /old_locus_tag="GCM10011574_38830"
     CDS             complement(20196..20393)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS19190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_38830"
                     /product="hypothetical protein"
                     /protein_id="WP_142572245.1"
                     /transl_table=11
                     /translation="MDEPQPVTLPNGRNLKCDTCENELFEPRRWKLQTTGMTFMNLDWA
                     NRDATCFVCSSCRRIHWFHW"
     misc_feature    complement(20345..20359)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.48"
                     /tool="antismash"
     gene            20498..21130
                     /locus_tag="IEY80_RS19195"
                     /old_locus_tag="GCM10011574_38840"
     CDS             20498..21130
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547810.1"
                     /locus_tag="IEY80_RS19195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38840"
                     /product="LysE family translocator"
                     /protein_id="WP_142572244.1"
                     /transl_table=11
                     /translation="MDVYGALASFAAIVALLTLTPGLDTALILRTSLLAGRRSAWAVVL
                     GIQGGTLSWGMLTAAGLSALLTASQVAYEVLRWAGVAYLIWMGARMLWHSRTSQGDDAA
                     PPGPPEAGWGRAFRRGLLTNLLNPKVGAFYVAVLPQFMPRGVPHAVMGVLLAGVHVCEA
                     LVWSAVLIGFTGMVRGWLRRPPVGRALDRLTGLVVIGFGLRLAIQQS"
     gene            complement(21090..22502)
                     /locus_tag="IEY80_RS19200"
                     /old_locus_tag="GCM10011574_38850"
     CDS             complement(21090..22502)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_LCL (12-287). E-value:
                     1.3e-27. Score: 88.6. Matches aSDomain:
                     nrpspksdomains_IEY80_RS19200_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IEY80_RS19200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_38850"
                     /product="condensation domain-containing protein"
                     /protein_id="WP_142572243.1"
                     /sec_met_domain="Condensation (E-value: 2.2e-21, bitscore:
                     70.8, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTVAFSGTREGQAPLTWGQRLMWRAVHLMGDSQTFLSCPWVLPV
                     YGRRDLGSVLDALRVLLERHESLRTTFALTPEGPVQRVGRGGELTVELVDAGQDRALRV
                     AERLAGELGRTPFAHDRDLPLRCAVVVKNGRPMALAIAFSHLAVDFQALNTLSEEWKVL
                     LRGEGLPPAEWQPMDQAAAEREEPYPARSAKSVRYWHSVLAEGPLDVFDHPPREADDPR
                     FIEVGMESVALAIAAQRLAERWTMSTTSVLLAACATVLTVVSGRPRAVMQLVHSNRRDA
                     RVRAMVATVEQDGLFVLDLPATDFAAVCRAAQRGALRAYRNAHYDPFEMQAMREEIGRR
                     RGREPDLDAFFNDRRTVGTWPGLPPVGPDEDVARLTENTTTYVTNAWPGVRFKAFFTVV
                     SAPDTGKLSLIVDTAYLPPGTAEAMLRGVENLLVRALTEEVPIAAVPEVCGIGPYDERL
                     RTAGSPGADRSR"
     aSDomain        complement(21642..22466)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY80_RS19200_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.30E-27"
                     /label="IEY80_RS19200_Condensation_LCL.1"
                     /locus_tag="IEY80_RS19200"
                     /protein_end="287"
                     /protein_start="12"
                     /score="88.6"
                     /specificity="C activity: active"
                     /specificity="Active site motif: SHLAVDF"
                     /tool="antismash"
                     /translation="QAPLTWGQRLMWRAVHLMGDSQTFLSCPWVLPVYGRRDLGSVLDA
                     LRVLLERHESLRTTFALTPEGPVQRVGRGGELTVELVDAGQDRALRVAERLAGELGRTP
                     FAHDRDLPLRCAVVVKNGRPMALAIAFSHLAVDFQALNTLSEEWKVLLRGEGLPPAEWQ
                     PMDQAAAEREEPYPARSAKSVRYWHSVLAEGPLDVFDHPPREADDPRFIEVGMESVALA
                     IAAQRLAERWTMSTTSVLLAACATVLTVVSGRPRAVMQLVHSNRRDARVRAMV"
     CDS_motif       complement(22284..22337)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY80_RS19200_0001"
                     /evalue="1.20E-06"
                     /label="C2_LCL_024-062"
                     /locus_tag="IEY80_RS19200"
                     /protein_end="73"
                     /protein_start="55"
                     /score="21.0"
                     /tool="antismash"
                     /translation="DALRVLLERHESLRTTFA"
     misc_feature    22556..22571
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     misc_feature    23017..23030
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     gene            23020..23904
                     /locus_tag="IEY80_RS19205"
                     /old_locus_tag="GCM10011574_38870"
     CDS             23020..23904
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS19205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_38870"
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="WP_142572242.1"
                     /transl_table=11
                     /translation="MTRHGFTLTAQGPFDFGATLRFVEDWPATSGLPSDGHALRFAYCA
                     ESDWLPLGVTVTAAPDGVAVATTRAAGPPIRGEVARILSLDVDGSGFAAAGEADPVLGD
                     LQRKSPGLRPLGFWSPWEAACWAVIVQRSSMLIAARLKQRIAERYGAKVVVDGATYTAF
                     PPPMTLLQAGGLGLPAQKEEWLRGLARAALDGVLTSEHLRALDPQEALAELRALPGVGP
                     FSAGLILIRGAGAPDAFPGDEPRLFAILREAYGLPEDAPPAAYRKAAEAWRPYRSWASF
                     LFRASGYGVLERS"
     misc_feature    24661..24673
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     misc_feature    24670..24685
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.75"
                     /tool="antismash"
     misc_feature    complement(24739..24754)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.52"
                     /tool="antismash"
ORIGIN
        1 ctccgtcgcg cggcacgtag gcgtcgagat gcaccagtcg tgagacccgg ccgccggcgc
       61 gatcggcggc ggcggcgatc accatccccc cgtagctgtg gccgacgagc gtcgcgctcg
      121 tgatgcgggc gcggtcgagg agccgcacca cgtcgccggc gtgcgtgtcg aggttggcgg
      181 tcgcgaccgt cgcgttgtcg tcgtccggcc gcagaccggt cagggtcagg gcgtgcaccg
      241 catgaccggc gcgctccagc agcgggacca ccgcctcgaa cgaccaggcg ccgtgccagc
      301 cgccgggcac gagaacgaac gtcgccatac gtttctcctt ctctctcacg tcgcggcgtc
      361 gaggtgcgcc gcgacgccgt gtggtccggc cgggcgcttc gcgcgaccgg gaaccactcc
      421 gcatggagga agtgtcatga gatcaagccg tggcgggcca ccgataggat gccaaatgat
      481 gcctgttcgc cgccaacctc gcctgacggc cggtgtgacg tcgcatatct ggccgtccgg
      541 cgggcgccac ctgtggccgt ccggtgagac aagtgcagtg cagtcgcacg cacggggaca
      601 tctggtgtac gcggccagcg gcgtcctggc agtctgcacc gagcgcggca cgtcgatcgt
      661 tcccgccaac cgggtcgcct ggaccccggc cgggttcacg cactaccacc gcgcccacgg
      721 cgacaccgac atgcggatcg tctttctccc gccgtccctc gcccggctcg tacccgagca
      781 tcccgtcgtg ttcctggcct ccaacctcgc ccgcgaggtc ctgctcgccc tgaccggccc
      841 ccgcaactac gacgacgcgc tcgtctacag ccgctccgcg cgccttcgtc tccttcgcgt
      901 cctcgtcgac gagctacgcg aggcacacga acagccactg cacctgccgg agccacggga
      961 cgaccggctg cgggccgtcg cccggttgct gtacgagaat ccggcggaca acgcctcgct
     1021 ggccgagctc gggaagacga tcggagccag cacccgcacg ctcagccgat tgttccgcga
     1081 cgaactcggc atgaccttct acgagtggcg cacccagcta cgcgtccacc acgcgctcgt
     1141 gctcctcgcc gacggccacg acaccacccg gaccgcctac gcctgtggat gggccaaccc
     1201 gagcagcttc atcacggcgt tcaccgacat catcggaacg accccgggcc gctaccgcac
     1261 cggtcgcgag accaccattc cagcgcgcct gaaaagcatg attcgcgacg tcgagtaggg
     1321 gcgttcccgc cggcctccgt cacgtgaccg ccatgtggcc ggcggtgaaa ctcccagctc
     1381 ggctcgccga agcggcgaac gtacgcgcga cagggccggg aagccgcgag atatgcccgg
     1441 ggaattgttt gacagcgcat ttcgagtgga tcacgatcac atcgaaatcg gtttcacgga
     1501 acggcgccct gagggggatc gatgcgtttt ctgcgggctt cgttggggat cggcattgcc
     1561 gcgattctcc tggccgcgtc gttcacgggg cccgcccagg cggcgcccgt ggacgtgcca
     1621 gccggttacg actgcgcggt gacctatgcc agcgtggggt ggaccaccgg gttcacgacc
     1681 aggttgacga tcaccaacac cgggaccctg gtgttcggcc cctggatcct gcagttcgtc
     1741 ttccccggag ggcagacgct catgcaaggg tggaacgcga ccttctccga aaccccgccc
     1801 agcgtccagg ccgccaatcc gatctggcag ccgagcatcg atcccggcac gagtttctgg
     1861 atcggcttca acgccaacgg ggccgacgaa caccccaccg gtttcacgct caacggcgtc
     1921 ccctgcgcgg tgacctacgg gccttactga tcgcagcgcg gtccgatgcc tgcggcggac
     1981 ggccggtctc cttcacggag ccggtgcgac gctgtgccgg tgtggacgag gggagacctt
     2041 cccgccgccg ccgtcgccgc cgccgtcgac cctccggcgg ccggccggag ggtgcgaggg
     2101 ccagagggcg gccggggcgg gtcaggggcg gcggttggac aggacgagcg tggcggcgga
     2161 ggcgaacatg ccgccgttgc cgaggaccac gccgacctcg acgccgggca cctgggcggc
     2221 cgcctcgccg cgcaactgcc gtacggactc ctggatggcg aacatcccgt acatgccggt
     2281 gtgggtgtag gagaggccgc cgccgttggt gttgagcggc agccggccgc cgggggaggt
     2341 gtggccctcg gcgatgaacg gcccggcctc gccgcgcttg acgaagccga ggtcctccag
     2401 cccgtagatg ggcacgtgcg cgaaggcgtc gtagatcatg agatggtcca cgtcgtcgtg
     2461 ggagatgccc gcctcggcga aggcggcctc gccggagcgg cggaaggcgg cggaggtggt
     2521 gaagtcctcc atctgggaga tgatcggcga ctcggcggac tcgccggagc cgagcagatg
     2581 gaccggcgac ctgcgggcgc gctcttcggt cgtcacgatc agcgccccgc cgccgtcggt
     2641 gacgaggcag cactccagca ggtggaaggg gtaggcgacc atccgggagg cgagcacgtc
     2701 ctcgacggtg atcaggtcct ggaacatggc ccgggggttg cggtgcgccc accggcgctg
     2761 cgcgaccgcg acctccgcga gctgctcgtg cgtgagcccg gtctccttca tgtagcgcag
     2821 cgccgtcagc gtgaacatgg tgggcgggcc gagcacgccg tacggcatct cgaactggcc
     2881 gatcagcgag tcggggccga gggcgggccg gggcgcgccg acccgcgacc gcccggactc
     2941 gccgtgcgtg atgagcacgg tcgtgcacag cccggcccgg atggccgcgg cggcgtgccg
     3001 tacgtggaag aggaaggacg agccgcccac ccccgtgccg tcgagccagg ccggagcgat
     3061 cccgagcgcg tgggcgatct ggatcgggcc gggcacgccg acggtggcga ccccgtcgat
     3121 gtcgtccttg gtcattccgg cgtcggcgag agcgttgcgc gcggcctgga ggtggagctg
     3181 cgcggtggac atgtggggca gcttgccgag ctcgtcggtc tcggccgcgc ccgcgatgac
     3241 gatgttcacg cggcggctcc ggtgggggcg tcgtcgacgg cggaagcggg ggtgaagagg
     3301 gggacgtgca cgtcgccgcg ctgttcgaac accacgcgca gctccatgtc gaggggcagg
     3361 ttctccggcg tgatctcgac gccgacgatg ttcgtcatca tccgcacgcc ctcctccagc
     3421 tccacgaccg cgatcgcgta cggcccgtcc tgctcgaagc cgggagccgg gcgatggctg
     3481 atcacatacg agtagagggt ggccctgccg ccggccgtca cccatgtgac gtcgtcggag
     3541 ccgcagtgcg ggcaggcggg ccgtggatag aagaagtgcc gcgagcaggc gtcgcagcgc
     3601 tggatccgca gccgcccctc cgccgtgccg tcccagaacg gctgggtctc cggcgtcggc
     3661 ttcgggacgg gtttgtgcga tgcggtcatc gttctcctcg gaggcggagg aagtcttaga
     3721 gtcggattct agaactccgg tctagagttg gcgagggtct tgtcgtcagg ggctcgggac
     3781 gccgttgccg cgccggccgc gaccggccag caggtcgtcg agggacggca ccggctcggt
     3841 ggcgcgcggc cccggctggg cgagctggac cagaacgccg tgcgcctcct tcgggtggag
     3901 gaagacctcg cgccagcggg gttcggcgag gttgaggccg aacagccggt agccgcgccc
     3961 gcgcagcgca tccacggccg cctcgatgtc ggtgacgtgg aagttgaggt ggtggacccc
     4021 gcctctgccg cgggtgaggt cgaagaagct gtcgaagaac gaggatccgg ccagcggctc
     4081 catcagctcg atcttgctgc cgttggcgta cctgagctgg agcgtccggt agccgttcac
     4141 cacgttgtcg cccccgccga ggtaggcgcc tcccagcagg cctcgataga gcggcagcag
     4201 gtccctgatg cgcggcgcgg cgacggcggt gtggtcgaag gccgcgtcca gtccggccag
     4261 ttcctcggcg atgtccaccc gtcctccttc gatcgaaatc ctagaatctc attctagtca
     4321 gtcgatcccc aggaaacacg tgctcacaac ccttgactcc agccgtgagg aggcggagca
     4381 ttcgtggaaa tgaattctag agcttgcttc tagaactcat ctcagggacg ggggctgacg
     4441 agaaaggcgt gtcaatgggc ctgtcctacg tacgcgagct cgacgagtac ccaacgggtg
     4501 cccgccgcat gaagatcctc acgatggccg tgctggccgt cctcatcggt tcctacgagg
     4561 cgcagatcgc ccccgtggtc ccgctgctcc tcaaggacct cgacatgtcc ctcgcgacgt
     4621 acggcgcggt gtccggggcg gcggcggtcg cgggggcgct cgcgtcggcg ctcggcggca
     4681 ggctaaccga tcggatcggc agggtgcgcc tgctggtccc gctgatgctg ctgaccgccg
     4741 tgtgctgctt cggcatgacg ctcgtgcaca gtccacggga cctgctgatc gccaggatcg
     4801 cgctggcctt cgtcgacggg gtggcgatgg cgagcacggc gccgctggtc cgcgacttct
     4861 caccgcgcct cggccgggct caggcgttcg gcttctggac ctggggcccg gtgggagcca
     4921 acttcctcgc cgccgccgtc gcgggctgga cgttgccgat cttcgacgac tcctggcggt
     4981 cgcagttcgt catcatgggc tgcttctcgc tggtcatctc gatcgtcatc gccttcaaca
     5041 tcgccgacct gtcgcccgag ctgcgcgcgc agatccagca caccgagcgc aaggccgccg
     5101 acgtcgtcga cctgaccagg ccggccaggg tctcctcgct gttcgtacgg cccaacatct
     5161 gggcccacgt ggtcggcatc tcgctgtggc tggtgctcta catcacgctc acgctcttcg
     5221 ggcagaccat gctggtcggc gccctgggca tcacgaccgc agaggcgtcc acgatcatgg
     5281 cgtgcttctg gagcctcaac ctgatcacgc tgatcgtcgc cggccgcgtc tccgaccgca
     5341 cccagctgcg caagccgatc acgctcgtcg gcaccgtcgc ggccgtggtg gtcaccgcct
     5401 acctggcgta catcctcggc ggcgaaggcg tctccagcgg catgctcatg atcgtcggcg
     5461 cgctgctcgg cggctcgctc ggcgtggcgt acgccccctg gatggccaac tactccgagg
     5521 acgccgagga cgtcgacccc cggctgcagg gcacggcatg gggcctgttc ggcttcctca
     5581 ccaaggcgat cgccgtggtc ggcctgctgg tcatcccgca cgtggtcgag gccacgagct
     5641 ggcagacctg gctggtggtc tccctggtgt gcctggcgct gttcgccccc gccgtcttcc
     5701 tgttccacgg cccctggcgg cgcgagcacg ctgtgaccgc cgaggaccag gaggccaggg
     5761 tcgcggtggc cgaatgaggc ctgcccggac gaatcagacc ggcgggtagc cgccgaggcc
     5821 gttgccgagc aggccgaaga cccgttcgac gtccgcgcgg tgggcgcgcc cgatctcctc
     5881 gtcggacccg ccctcccgca cccgctgccg cagccgccgg tagagcgccc gctgcgcgcc
     5941 gaccagcgtc gaggcgacga tgcggggcag cgggtcgccg ggctccgcgc ccgcctcggc
     6001 cgccagcgcg tcggcgagca cccggatgat ccgctcgttg acctcgtgca tcttccgctc
     6061 aagtgacggg ttgccgctca cgaggtcgaa gaagctgcgc ggatggacga ggtcgcgccg
     6121 catgcccggg atgaacctgg tctgcgccag gcacagcgcg cggaaggagt cgaggatgga
     6181 gaacccggcc gggcggtcgg tgaccgccgc cagcgacatg gcctcccggt cctcggcccg
     6241 gtagaagacc aggtcctcct tggtcgggaa gtggttgaac accgtcttct tcgacacctg
     6301 cgcggccgcc gcgatctcgt ccacggtgac ctcgtcgaac ccccgggccc ggaagagcgc
     6361 gttcgcggtg tcggcgatga gctgccgggt ccggttcttc ttcagctccc gcagcccgcc
     6421 cgcactcatg ggcacagcgt atcggcctcc gttggttaca cctggtgtac tgttgcacca
     6481 agtgtaacaa atggggaggc aggatgacgc atccggcggt gcacaccacc ggcctggcca
     6541 agcactacgg cgacgtcgag gccgtgcgcg gcatcgacct gaccgtgcgc aaaggggaga
     6601 tcttcggctt cctcggcccg aacggggccg ggaagtccac gacgatcagc atgctctgca
     6661 cgctgaccac gcccacgtcc ggcgaggcgc gggtggccgg acacgacgtg gtgcgcgaac
     6721 gcgacagcgt gcggcgctcg atcgggctgg tgttccagga cccgacgctg gacggctatc
     6781 tgacggccga gcgcaacctg cgtttccacg ccgagctgta cggcgtgccc cgcgcggacg
     6841 tcggtccacg gctgcgcgga gtgctggaga tggtggggct gtgggacagg cgcgacgcca
     6901 gggtcgcgac gttctcgggc ggcatgagac gaagactgga gatcgcccgc ggcctgctgc
     6961 actcgccgcg ggtgctgttc ctcgacgagc ccacggtggg cctggacccg cagaccagga
     7021 gctccatctg gtcctacatc cgggagctca aggacgccga ggacatcacg gtcttcctga
     7081 ccacccacta catggacgag gccgagcact gcgaccgcat cgccatcatg gacggcggcc
     7141 agatcatcgc gctcgacacc cccgcggcgc tgaaggccgg tgtcggtaag gaccgcgtcc
     7201 agattgagac cgatgacggc gcggcggccg tcgccgccct ggacgatcgg ttcggcatcc
     7261 aggccgtcgc gtccgggggc gtggtcgtct tccacgtgga cgagggggag cggttcgtcc
     7321 cggagctgtt ctcgcggtcg gggctgccga tccggtccgt cagcgtggcc aggcccagcc
     7381 tcgacgacgt gttcatgtcc tacaccggcc ggtcgatccg cgacgcggag tcgaccggcg
     7441 gcgcacgcgg cccggccgcg ctcgccgcgg cgcgaggagg ccggcgatga cgttgcccat
     7501 cacggcggtc cgggtgcccg ggcgcagcgc gacgagcgag ctgcgtgccg tcaaggtggt
     7561 ctggcagcgc gagatcatcc ggttcttcaa cggcccgctg cgcatcctca cctctctcgt
     7621 gcagccgttc ctgttcctgt tcgtcctcgg caccggcctg tcccagctca cctcgggcgg
     7681 caccggcggg ctcggcctgc ggaccttcct ctacccgggc atcctcgcca tggccgtcct
     7741 gttcaccgcg atgtcctcgg ccgcctcgat cgtctgggac cgggagttcg gcttcctgcg
     7801 cgagatgctg gtcgcgccgg tgtcccgagg gtccatcgtc ctcggcaaat gcctgggcgg
     7861 ggccaccgtc gcgtccttcc agggcctcgt ggtcatctgc atcgccggtc ccgtgggcgt
     7921 gccgtacgcg ccgggcctga tgctcggcgt gttcggcatc caggtgctgc tggccttcac
     7981 catcacggcc ttcggagtcg cgatgtccgt gcgggtcaag cagatgcagt cgttcatggc
     8041 gctcaaccag ctgctgatca tgccgctgta cttcatgtcg ggcgcgatgt tccccgcgtc
     8101 gaacctgccc gcgtggctga ccgcgctcaa ccggatcgat ccgctctcgt acgccgtgga
     8161 tcccatcagg cggctggtct tcgcgcacct gaacctgacg cccgccgtac gggcccggct
     8221 cgcgcccggg ctgacgtggg gcgggtggca cgtgcccatc ctcgtcgagg tggccgtcct
     8281 cgcggtcctc gggctcgccc tgctggcgac cgcgatcgca caattcggca gagccgactg
     8341 atcggcacaa ttaggcagag ccgactggac agcgcggttc ggcagagccg actgatcagc
     8401 acagttcggc agagccgact gagcgtccga cggcacgggc cggggtgtgt gaagccgatg
     8461 gacgccgacg ggcgccggtt cgctatggtg tgggccatgt cgagccctga ggcatccaag
     8521 aagggggctt tcggtcacgc cgtcagcccc ctgcaccact gagttcgtga atccgtcgtc
     8581 ccgccgcgtc cgcggccgga cgaacgcgct cccgggtgct gaccgcggtg acgagacgtc
     8641 tccttctcgt gcttctcatc gcctcggagc cattcgatgc ctcttccgct gtattcgctc
     8701 gccctggcgg tcttcgccat gggcacctcg gagttcatgc tcgccggcct cctgccggac
     8761 atcgcctcag acctcggcgt gaccgtcgga acggccggca cgctcacctc ggccttcgcg
     8821 atcggaatga tcgtcggcgc cccgctcatg gccgggctcg cccgcgaccg gtctccccgg
     8881 tccggccttc tcggcttcgt cctcgtcttc gtggcggccc acgtcgcggg cgccgccgcc
     8941 tccggcttcc ccgtcctgtt cgcggcccgg atcgtcgccg cgctcgcgaa cgcggggttc
     9001 ctcgccgtgg ccgtttcgac ggccgccgct ctcgtccccg agaaccggaa ggggcgggct
     9061 gtcgccgtgc tgctgtccgg aacgacggtg gcgaccgtcg cgggggtccc gggaggggcg
     9121 gtcctcggca cgctgctcgg atggcgggtc acgttctggg ccgtcgccgt cctctgcgtg
     9181 cccgcggccg tcggcatcct gcgcgggatc ccggcgcgtt ccgcgcaggc gggcgaggcc
     9241 gacgggcggg tcctgcgatc ggaactcgca cagctcggga accggcgcct gatcctggtc
     9301 atgctgctcg gcgcactggt gaacgcggcg accttcgcga gcttcacctt cctcgccccc
     9361 atcgtgaccg gcaccgcggg gctggatccg ctgtggatcc cggtcgtcct ggtgctcttc
     9421 ggcgtgggct cgttcgtggg cgtcgccatc gcgggacggc tgtccgaccg gcaccccgga
     9481 ctggttctcg cgatcggcgg tccgctgctc ctcatcggct ggcccgcgct ggccgtcacg
     9541 gccggagagc cggtcgttct gctcatcctg gtgttcgttc agggcgcgct gtcgttcgcc
     9601 ctgggcagca ccttgatcac gcgggtgctc tacgaggcgg cgggagcgcc gaccatggcc
     9661 ggctcgtacg cgacggcggc gctcaacgtc ggcgccgccg ccgggccgct cctcgcggcg
     9721 gccaccctcg gcaccgccgc cctgggcaaa ggggccgcgg acctcggccc actgtgggtg
     9781 agcgcgcttc tcgtcgcgat cgcactgctg atcggcctcc cctccggggt tgtccggcgc
     9841 cacggccctc gtgaacgcgg cgcggagcag cggaccgaac cgaactaagc cgcgtctgtc
     9901 ggcgagaagt tccgactatc ggaacggccg gttctacttt gcgtgttcat taagtaactt
     9961 tccgcaaggg ataccggctc gccgagcgag gaggccgagc atgaccgcgg acaccgtgga
    10021 cacgtccatc aaggggacca ccggcatcgg tgacgacggc ggcatcgccg ccgtcacgag
    10081 cgccgtccgg ggacgggtcg acgagctgct ggccggcttc ctcgacgccc ggcgcccccc
    10141 ggtcggggat ccggacgtcg ccgagggcta ccggctgctg cgcgagtttg tcgtcgaggg
    10201 gggcaagcgc atccggccgc tgctgtgcta ctggggctgg cggggcgcgg gcggcgagga
    10261 gccgcacgag gagcgggccg tcatcaccgg cgcggcgctg gagctctacc acgccggtct
    10321 gctgatccac gacgacgtca tggacggcag cgagctgcgc cgcgggcgcc ccaccatcca
    10381 ccgggggctc gccggggccc cgcgctggac gggcgcggag accttcggcc agtccgccgc
    10441 catcctgctc ggagtgctcg cgcaggcgtg ggcggacgag ctgctcgcgg acgccgtcgc
    10501 cgccgactcg cgggggcggg cggcgcgcga gctgttcaac cggatgcgca cggaggtcgt
    10561 caccgggcag tatctcgaca tcctggcgca cgcccgcgcg gacgcggacg tcgaacgggc
    10621 actgacggtg atccgctaca agacggcccg atacacggtg gagcgcccgc tgcagatcgg
    10681 cgcggcgctc gccggggccc cgcccgccct gctggatgcg tactcccggt tcggcctgcc
    10741 gctcggggag gcgttccagc tgcgcgacga cgtcctcggt gtcttcggcg accccgccgt
    10801 caccggcaaa ccggtcctcg acgacctgcg tgagggaaag cggaccgtgc tcatggcgta
    10861 cgcgttcgcg cgggcgcgag gaccggaacg ggaccggctg cggacctggc acggtgcccc
    10921 cgacctggac gaacggcggg cggccgagct caggcagatc atcgtggaca ccggagccct
    10981 cggcgaggtc gagggcctca tcgccctgcg ggccgtgcag gcgctcgacg cgctgcgcga
    11041 ctgcgcgatc gccccggagg cggcgcgggc gctcgcggtg ctcacggagc ggctcacccg
    11101 ccgcgtccgg tgaggcgcgc gatcggtacg cccgcctgtc tcctcacgcc cgccaccgga
    11161 acgctccggc ggcctccgca cgcggccgtt cgggcattcg ccgtacgggc gcctggggca
    11221 tgcggcgcag cccgtgcctg tggcgcaggc agcgcgggcg atgccgccgg tgcacgcggc
    11281 gcggccctgt ccgggccggt acgactctga tctttccttc cccctccgcc gctcggcgac
    11341 gagcgtgtcc agtcaccgaa caaccggccg ccgtgccgat cacagatggg gtgatgtgcc
    11401 gtgaccgaaa acacgatgcc gaccgacaac cggttgagcc tcagcaccag ggccgcgcgc
    11461 aacctggcca cgacgaccaa gacgccgccg cagatgcagg agatcacctc ccgtcatctg
    11521 ctgcgcgtgc tgccctgggt cgaggcggtg ggcggcgcct accgggtcaa ccggcggctg
    11581 acctaccaga tggccgacgg gcggctgacg ttcgtctcga ccggggcgga cgtgcgggtc
    11641 atctccgccg agctgtgcga gctgcccgcc ctgcgcggct tcgccgacgc cgacgtgctc
    11701 gccgccctgg ccgacctgtt cacccagcgg gagtacgagg ccggccaggt catcgagcgg
    11761 gccggcaccc cgatggacga ggtcctgctc ctggcccacg gcaaggtcga caggctcggc
    11821 gagggggagt acggcaacga gacgcggctc ggggtgctgg ccgacggcga gtacgtcggc
    11881 gagcacatgc tggtgaacgc ggacgcgcgg tgggagtgga cggtcaaggc ggtgacggca
    11941 tgcacggtgc tcgcccttgg cagggaggag ttcgaacggc tgctcacgct gtcggacggc
    12001 ctgcgtgagc acgtgcaggc ctatcgggag gacccggacc ggccggtgaa ccggttcggc
    12061 gaggcggaga tcgctctggc ggcggggcat gtgggtgagg cgacgctgcc ggggacgttc
    12121 gtggactacg agctgggtcc gcgtgagtac gagctgagtg tggcgcagac gattttgcgg
    12181 gtgcactcgc gggtggcgga tctgtacaac gagccgatga accagaccga gcagcagttg
    12241 cggctgacga tcgaggcgtt gcgggagcgt caggagcacg agctggtcaa caaccgcgac
    12301 ttcggtctgc tgcacaacgc cgatctcaag cagcgcctgc acacccgttc gggcccgccc
    12361 acccccgacg acctcgacga gctgctcgcc acggtctgga agaacccgaa cgtcatgttc
    12421 gcccacccca aggcgatcgc ggccttcgcc cgccagtgca acgcccgggg catctacccc
    12481 cagaccgtgg agttcaacgg tcagaaggcc ccggcctggc gcggggtgcc gatgctgccg
    12541 tgcaacaaga tcccggtgaa cgacaagggc atcagctcga tcatggtcat gcgcctgggg
    12601 gagaaggacc agggcgtcgt cggcctgcgc cgcaccggac tggtggacga gtacgagccc
    12661 ggtctgtcgg tgcgcttcat gagcatcgac gaaaaggcga ttctctccta cctggtgacc
    12721 acctactact cggcggccgt cctggtcccc gacgccctcg gcatcctgga gagcgtcgag
    12781 gtcctgtgat gtcctcctac cggctgccgg acttctacct cccctatccg ccccggctga
    12841 acccgcacgt ggagaccgcc cgggcgcaca cgcgggggtg ggcggcggac atgggcatgc
    12901 tcgacgaccc ggacatctgg accgaggagt cgctcgacgc gatggactac ggcctgatgt
    12961 gcgcctacac ccatcccgac tgctccgcca ccgaactgga cctggtcacg gactggtacg
    13021 tgtgggtctt ctacttcgac gaccacttcc tggagacctt caaacgcagc agggacctgg
    13081 acggcgccca ggactacctg gaccggctcg acgcgttcat ggcggacgac ccgcccgagc
    13141 cgacgaaccc ggtggagcgg ggcctggccg acctgtggcc ccgcaccgtg ccggccatgt
    13201 cgcaggcgtg gcggcgccgg ttcgtccggg tcacccgcga cctccttcag gagtcgatgt
    13261 gggagctgtt ccacatcgag cgcgaggccg tctccaaccc gatcgagtac atcgaggaac
    13321 gcaggaaggt cggcggcgcc ccgtggtcgg ccgcgctggt ggagcacgcg gccggcgcgg
    13381 agctgcccgc ccgtctggcg gactcccggc cgatccgggt gctgacggag tcgttcgccg
    13441 acgccgtgca cctgcgcaac gacctgttct cctacgaacg ggaggtgctg cgggagggcg
    13501 agctgtccaa ctgtgtgctg gtcagcgagc gtttcttcgg ctgcgacacc gagcgcgccg
    13561 tggagatcac caacgacctg ctcacctccc ggctgcacca gttcgagcac accgcgctga
    13621 ccgagcttcc ggcgctgttc gccgacgaag gggtgctgcc gcccgagcag gcgctggtcc
    13681 tgagctacgt caagggactg caggactggc aggcgggcgg acacgcctgg cacaccgcct
    13741 ccagccgcta caccaagacc gcgggacagg ccgggttctt cgggatgaac gtggcccgcg
    13801 cccacctcac gggcgcgggc ggcctgcgca accacaccca ccggcccttc gccgaggccg
    13861 cggtgcggct gccgcagccg tacatgccgt tcgaggtgcg cgacaacccg cacctggacg
    13921 cggcgcgagc ggcggacgtc gaatggtgtg ccgagatcgg cttcttcgac ggggtccccg
    13981 gcatcccggc gaccgccgtg tggaacgaac cgcaactcgt cggcttcgac ctcgccctgt
    14041 gcgcgtccgg catcaacccg gacgccacgg ccgacgaact gatcctggcc accaactggc
    14101 tggcctgggg gacgtacggc gacgactact atccccgggt ctacggggtg gcgcgcgacc
    14161 tgatcggcgc gaagctcggc aaccggcggc tcaaggagtt catgccactg gacctcgtcc
    14221 cgcgcctgac cccgatgacg gggctggagc gcgggctggc cgacctgtgg ccgcgcaccg
    14281 ccgggccgct gccggagggc tcccgccggg ctttccgcgt cgcggtcgag gaaatgatcg
    14341 acagctgggt gtgggagctg gccaaccagg cccagcaccg tgtgcccgat ccggtcgact
    14401 acatcgagat gcggcgcagg acgttcggct cgcagatgac gatgagcctg gccaggctgg
    14461 cgccgggccg ggtcatcccc gacgagatcc accggacccg cgagttcctc ggcatgaccg
    14521 acgccgcgca ggactacgcg tgcctgctga acgacctgtt ctcctaccag aaggagaccc
    14581 agttcgaggg tgagctgcac aacgccgtcg tggtgctggg caccttcctc gactgcgcgc
    14641 cgggcgaggc ggtgaccgtg gtggacgcgc tcatgaccag ccggatgagg cagttcgagc
    14701 acatcaccac cgtcgacctg cccgccctgc tcgaccgcat cgaggtgggg gaggccgtgc
    14761 gggagtcggt cgggggatac gtggccgacc tgcgcaactg gatggcggcg atcctgcgct
    14821 ggcaccagcg gtcccggcgc tactgcgagg aggagctgcg caggggtccg gcggcccggt
    14881 ggtcccaggg cccgacgggc ctcggcacgg ccaccgctcg ctttcttccc ctggctccgc
    14941 cggcttcacc ggcttccctg gctcacgcgc tgccggtggg ggcgccatga ccgagtcgcg
    15001 cctgaccctg agcacggccg ccgcgcggaa cctggcgacg accaccaaga cgccgccgca
    15061 gatgcgggag atcactcccc ggcacctgct gcgggtgctc ccgtggacgg aggtccaggg
    15121 cggcgtctac cgggtcaacc gccggctcac ctgcacggtg ggggacgggc gggtgagctt
    15181 cgtctccacc ggggcgcggg tgcgggtcat cccggccgag ctgtgcgaac tgccgtccct
    15241 gcacgactac ggcgacctgg acacgctccg ggcgctggcc gaccggttcg tccagcacga
    15301 cctgagctcg ggcgagccgg tgccacccgg acaggtggtg ctcgtcgccc acggcaaggt
    15361 cgcacgcgtc ggcgcgggcg cgtacggcgg tgaggccctg ctccaggtcc tcgccgacgg
    15421 agaccacctg ggggacctca ccggcccggg ggccccgccc gccaaggccg tcacctcctg
    15481 catcgttctc gtcctcgacc ggtcggtgct ggacaacctg accgcgctgg ccggcggcct
    15541 gcgcgagcat ctcggccgtc ccgccgaggc gcggccggtg aaccggttcg gcgaggcgga
    15601 gatcgctctg gcggcggggc atgtgggtga ggcgacgctg ccggggacgt tcgtggacta
    15661 cgagctgggt ccgcgtgagt acgagctgag tgtggcgcag acgattttgc gggtgcactc
    15721 gcgggtggcg gatctgtaca acgagccgat gaaccagacc gagcagcagt tgcggctgac
    15781 gatcgaggcg ttgcgggagc gtcaggagca cgagctggtc aacaaccgcg acttcggtct
    15841 gctgcacaac gccgatctca agcagcgcct gcacacccgt tcgggcccgc ccacccccga
    15901 cgacctcgac gagttgctcg cccgccggcg cagctcgcac tacttcctcg cccatccccg
    15961 ggccatcgcc gccttcggac ggcagtgcac gcggcgccgc gtgtatccag acgtcaccga
    16021 ggtgaacggg gcgacggtca tggcctggcg gggcgtgccg atactgccct gcgacaagat
    16081 cccgatcagc gagggagggc tcagctcgat cctggtgatg cgcaccgggg cggacaaaca
    16141 gggcgtcgtc gggctgcgcc gcacggggct gccggacgag tacgagcccg gtctgtcggt
    16201 gcgcttcatg agcgtcgacg aaaaggcgat cctctcctac ctggtgacca cctactactc
    16261 ggcggccgtc ctggtccccg acgccctcgg catcctggaa agcgtcgagg tgaactgagg
    16321 tgcgcctccg gccggggtac tcttcgagcg caccggccgg aggcggttcc tcggatcagg
    16381 tgagctcaag accgccgtcg agggtgagga cctggccggt gagccaggtc gcggcgggat
    16441 cggcgaggtg gaggatccac tcggccacct ctcggggctc gccacgtctg ccgaggggga
    16501 tgcggcgggc ctcgtcctgc ttggtctgct cgacgacggc ctcgggaaga ccggcggcgg
    16561 tgagcgcctc actctcggtc ggcccggggg ccagggcgtt gacccggatc ccgtctccgg
    16621 cgagttccac cgcccagctg cgggtgagct gctcgatcgc ggctttcgac gcggcgtagt
    16681 gcgccgcgcc gggcagcggc cggtggccga aggtgctcga tacgttgacg atcgatccgc
    16741 ccgtttcgcg caggtggggc agcgccgccc gggcgagcag gctgggcgcg gtgacgttga
    16801 ggtcgaacag gtcggtgacg cgtgccgccg tcgtctcggc cagcggcatg accgtggtcg
    16861 cgccggcgtt gttgaccagc acgtccaacc ggccccagcg gtcgacggcc gtacgcacga
    16921 tcgtctcggg cgagcccgcg acacggacgt cggcggcgag tgcggcgatg cgcgggtgct
    16981 gccgggcggt ctcctcaagg gcctgggcgc ggcggccgac cccgaggacc tgggcgccgg
    17041 cctgcgcgaa ggcgagggcg gtggcgcgcc cgatgcccga gcccgcaccg gtgacgacga
    17101 cgatccggcc ggcgaagcgg ccggttggct gtccggtcaa cgcgactccc attgttcgat
    17161 gttcgccaaa catcgaacaa gctaccatcg gtgtatgaag cgggcgcacc acccccaact
    17221 ggacgagatt tccctcaccg cggtcatggc ggcgctcagt gacccgatcc gggtgggtct
    17281 ggtccggttg ctggccgacg ggcgggagca cggatgggga gagctgcggg ccccggtcgc
    17341 caagtcgacg ctcagtcatc acctcaaggt tctgcgcgac gccgggatca cccgcacgcg
    17401 tcaggagggc acccgctgct tcgtcgtgct gcgccgcgac gacctggaga cccggttccc
    17461 cgggctgctc gctcccgtgc tggccgcggc ggagtgcgac ggggtgggcc gccaggtcgg
    17521 gctcgcggcc tcggcgtagc aaacgcgttc tcccctcatg cgcggcgcgg cgcggctaag
    17581 gtgaccgctg gccgatcaag atgtgattca cgagcgtcgc ggggtgaggt tgttcgtacc
    17641 gttggatcgc gcccgccggg cggaggcggc ctccgccctg ggcagcctgg aacgcgggat
    17701 ggaaatcctc ctgtgtctcg ccgccggcat gaggccgatg aacctgaccc aggtgcaccg
    17761 gtccaccggg ttctccaaga ccaccacgca tcgcctgctc gggagcctcc agcgacgggg
    17821 cctggtcacg cgtactggcg gcgactacac ggtcggcgga cgcctcgccg acctcgtgcc
    17881 tccgcgcggc tgggcggtcc agggccgtcg tctgccgggc tcccgcaggg tggtcctgcc
    17941 gcatctgctc cagctgtacg aggccacccg gcagacggtc aatctggccg tgcgggacga
    18001 gttcgaggtc gcgtacgtcg agcggctgta cggccacaac cgggtcacgt cgccgtcgga
    18061 cggcgtcgac cgggcgccgc tgcactgcac ggccacgggc aaggtgctgc tcgcctacga
    18121 cgcgggcctg cgcgccgcgt tcctcgccgc cccggccctg cggcggatga ccggccgtac
    18181 ggtgaccaga ccggccgcgc tggaacgcga gctcgcggcc atccgcggcg agggcgtggg
    18241 gtacgcgcgg caggagttcg ccgagggggt gtgctgcgcc gccgcgcccg tcttcggccc
    18301 ggacggcggt gtgtgcatgg ccgtcgcggt cgccgcgccg gtgggggcgg cggcgctgcc
    18361 gcgtatgggc gcggccgtgc gcaggaccgc ccaccagatc accggcgccc tcctcatgtg
    18421 atccccgttt cggggattgg ggccgccggg ttcggggaag gctcgaacgc gtcgagcggc
    18481 cgggtctggg gcgctccgcc cgccggtgtc aggaaccggc ggagccgtcg tggtctcggg
    18541 gagagtcatg cgtcgaggac agtacgcgtc ccgcttgatc ggctgggtcg gcctcgtcgc
    18601 cctaccggtg atcgtgctgc tcgcggcgtg cggaaccccg gagccgcaga tgcggccgcg
    18661 gcccgtggcc acggacggct cggcgtcccc gggcggtctg gtgtccacgg gcgatcccgt
    18721 gtccaccgcg gttcccgcct caccctcgcc cggcccgtcg gccgtctcgg ccgcggacca
    18781 tccggaggcg tgccggaacg ccgcctgcga ggtggcggtg cgcccggggg atcggttgcg
    18841 gctcgaccgg aagaccggcc tcgacgcgat cacgatcgtc tcgctcgacc agggcgagct
    18901 gcggctgcgc ttcaaggcgg gcgcgggtgc cttccgcgtc gagggcatga acaccggcgt
    18961 cagccagagc tgcgtcaacg gccgctgccg gacggagggc gggctgacgc tggccccggg
    19021 acggcccggc aggatcggcg acatccgcct gcggctggcg agcgtggcgc ccggctatgc
    19081 ggtcctggtc ctgtcgcccg cgtgagcatg acccgcgcat gacgggaccg gcccgcatga
    19141 ccggcgcatg accggaccgg cccgcatgac ccgcgtgcac gaccggcgcg tgaccggcgt
    19201 gcgtgatctg cgggcatgac gggcgtgcgt gacgggcgtg cgtgacctgc gcatccggtt
    19261 cggccgcgtc gacttcggaa atccccagcc tccgttaacc gcgaggccac cacgcctgcc
    19321 tacggtcgcg gccatggcat ggaagagcag ggtcaacgcc gccgtcgagg ggatgaccgg
    19381 ttacgtcatc acacgagcca ggccacgggc cgtaccggcc gcggagccgc gagacgagcc
    19441 gcgcccgccc gccgatcccg ccgccgaccg cctgctgcgc gcgcccgttt tcgtgctctc
    19501 cccggtgagg tccggctcca cgctcctgcg tgtgctgctg aacagccaca gcaggatcca
    19561 cgcgccgcac gaactgcacg tccggcgaat cgccgtcacc ctcaccaccg atcccgtacg
    19621 gcaggccatg gaggcggccg gtcaccgcac gagcgacatc gagcacatcc tgtgggaccg
    19681 actgctgcat cgggagctgg tcaggagcgg aaaggaggtc atcgtggaca agacgcccag
    19741 caacgtcttc gcctgccgcc gcatcacgac gtgctggccg gatgcccgat tcgtcttcct
    19801 cctgcgccac cccgcgtcga tcgcccggtc gtggcacgag gccgacccgc gagcccggcc
    19861 catggacgag gccgtgcggc acacgctgca gtacatgcgc cacctggagg atgccaggcg
    19921 ccgtcacgac gggatcgacg tccgatacga gcggctcgtc gacgacacgg aaggcgagct
    19981 gcgccggctg tgcgcctggc tgggcgtgga gtacgagccc gggatggtcc ggtacggcga
    20041 caaggaccac ggcgacttcg tgaagggcat cggcgactgg cgcgacaaga tccgcagcgg
    20101 gcgggtccag ccgggccgtc cgctccccgc ccccgaggag gtgcccgggg ccctgcgaga
    20161 gatcgccgcc gcctggggct acctctgatc tccgatcacc agtggaacca gtgaatacgg
    20221 cggcaactgc tgcacacgaa gcaggtggcg tcgcggttgg cccagtcgag gttcatgaac
    20281 gtcatgcccg tggtctggag tttccaccgg cgcggctcga acagctcgtt ctcgcacgtg
    20341 tcgcatttca gattgcggcc gttggggagc gtgaccggct gcggttcgtc catgccttcg
    20401 atgctaagcc gccgatggct ttcctggcct gccgcgataa tccgcggcga tcgggtgggt
    20461 gtcggttgtg caggggtgtg ggctaccgtg accgcccgtg gacgtctatg gtgcgctcgc
    20521 ctcgttcgcc gccatcgtgg cgctgctcac gctcacgccg ggcctggaca cggcgctgat
    20581 cctgcgtacg tcgctgctcg ccggccggag atcggcctgg gccgtggtgc tcggcatcca
    20641 gggcggcacc ctgtcgtggg ggatgctcac ggccgccggt ctgtccgctc tcctcaccgc
    20701 ctcccaggtg gcgtacgagg tgttgcggtg ggcgggcgtc gcgtacctga tctggatggg
    20761 cgccagaatg ctctggcaca gccgcacgag ccagggggac gacgcggcgc cgcccggccc
    20821 gccggaggcc ggatggggac gggcgttccg gcggggcctg ctgaccaacc tgctcaatcc
    20881 gaaggtgggc gcgttctacg tcgcggtgct gccgcagttc atgccccggg gcgtgccgca
    20941 cgcggtgatg ggcgtgctgc tggcgggcgt ccacgtgtgc gaggcgctgg tctggagcgc
    21001 cgtgctcatc gggttcaccg ggatggtgcg cgggtggctg cgcaggccgc cggtcgggcg
    21061 cgccctggac cggctgaccg gcctcgtcgt catcggcttc ggtctgcgcc tggcgatcca
    21121 gcagtcctga gccgctcatc gtaggggccg atcccgcaca cctcggggac ggcggcgatc
    21181 ggcacctcct cggtgagggc gcggaccagc aggttctcga cgccgcgcag catcgcctcg
    21241 gcggtgccgg ggggcaggta ggcggtgtcc acgatgaggc tgagcttccc ggtgtcgggg
    21301 gccgagacga ccgtgaagaa cgccttgaac cggacacccg gccaggcgtt cgtgacgtac
    21361 gtcgtggtgt tttcggtgag gcgggccacg tcctcgtcgg ggccgacggg aggcaggccg
    21421 ggccaggtgc cgacggtccg cctgtcgttg aagaacgcgt cgagatccgg ttcccggccg
    21481 cggcggcggc cgatctcctc ccgcatcgcc tgcatctcga aggggtcgta gtgcgcgttg
    21541 cggtatgccc tgagcgcccc gcgttgcgcg gcccggcaga cggcggcgaa gtccgtggcg
    21601 ggcaggtcga gcacgaacag gccgtcctgc tctacggtgg cgaccatcgc gcggacgcgc
    21661 gcgtcgcggc ggttgctgtg cacgagctgc atgaccgcac gcggacggcc gctcacgacg
    21721 gtcagcaccg tggcgcaggc ggcgagcagc acgctggtcg tgctcatcgt ccagcgctcg
    21781 gccagccgtt gcgccgcgat ggcgagcgcc accgactcca tgccgacctc gatgaaccgg
    21841 gggtcgtccg cctcacgcgg cggatggtcg aacacgtcga gcggcccctc cgccagcacg
    21901 gagtgccagt atcggacgga cttggccgaa cgggcggggt acggctcctc gcgctccgcg
    21961 gccgcctggt ccatcggctg ccactcggcg ggcggcagtc cctcgccccg cagcaggacc
    22021 ttccactcct ccgacagcgt gttcagcgcc tggaagtcca ccgccaggtg ggagaaggcg
    22081 atcgccagcg ccatcgggcg gccgttcttg acgacgacgg cgcagcgcag gggcaggtcc
    22141 cggtcgtggg cgaagggcgt ccggcccagc tcgcccgcga gccgctcggc gacccgcagc
    22201 gcccggtcct gtcccgcgtc gaccagctcg acggtgagct cgccgccgcg gccgacccgc
    22261 tgcaccggcc cctccggggt gagagcgaag gtcgtacgca ggctctcgtg gcgttcgagc
    22321 agcacgcgca gcgcgtccag gacgctgccg aggtcacgcc tgccgtacac cgggagcacc
    22381 catggacagc tcaggaaggt ctggctgtcg cccatcaggt ggaccgcccg ccacatcagc
    22441 cgctgtcccc aggtcagcgg tgcctggccc tcccgcgtgc cgctgaacgc caccgtcacc
    22501 atgagcccgt catcccctgg aaggccggct cgccgccgcg gccggtctct atgctgtcac
    22561 cgaaaagttt cgacacgatg cccactccat gatcgacacg gacatgccag ttagtccggg
    22621 ttttggtcac gccggacgtc gccgtgcaac ggaagaatag gcaacaggag cggagaggcg
    22681 acagtgaaag tcgcaagtct cctgccgaaa gctttcgaag gaaggcgttt ccgaggcgcg
    22741 gggccacctc ttttccgata cgccgaacgt gatcatcctg cggacggttg ccgacatggt
    22801 acttccccgc tctcgccggg gtcctcgttc ccgaggatcc gatggggcgg attgcggggc
    22861 ggatcgcatg ggggatcgca gggcgtcttg cggggcggat ccggtacggc ggatccggta
    22921 cggcggatcc ggtacggcgg atccggtacg gcccgcgggc ggtcgtgccc acgccgcccg
    22981 gcatgatcgt ctgtcggtcg ggcctcgtac gatgcgcgca tgaccaggca cggtttcacg
    23041 ctcacggcgc agggcccgtt cgacttcggc gcgacgttgc gcttcgtcga ggactggccc
    23101 gccaccagcg ggctcccctc cgacgggcac gcgctgcgct tcgcctactg cgcggagtcc
    23161 gactggctgc cgctcggcgt gaccgtgacc gccgcgccgg acggggtcgc cgtcgccacg
    23221 acgcgggccg ccgggccacc gatccggggc gaggtggcgc gcatcctgtc cctcgacgtg
    23281 gacggctccg gcttcgccgc ggccggcgag gccgacccgg tgctcggcga cctgcagcgc
    23341 aagagccccg ggctgcgccc gctgggcttc tggagcccct gggaggcggc ctgctgggcg
    23401 gtgatcgtgc agcgttcgtc gatgctcatc gccgcccggc tcaaacagcg catcgcggag
    23461 cgatacggcg cgaaggtcgt ggtggacggg gcgacctaca ccgcctttcc tccgcccatg
    23521 acgctgttgc aggccggcgg tctcggcctg ccggcgcaga aggaggagtg gctgcgcggg
    23581 ctggcccggg cggcgctcga cggcgtgctc acctccgagc atctgcgcgc gctcgacccc
    23641 caggaggcgc tggcggagct gcgtgccctg cccggcgtgg ggccgttctc cgccggtctg
    23701 atcctgatcc gcggcgcggg cgcgccggac gcgttcccgg gagacgaacc acggctgttc
    23761 gcgatcctgc gcgaggcgta cggcctgccg gaggacgccc cgcccgccgc gtaccggaag
    23821 gcggccgagg catggcggcc ctaccgctcc tgggcctcct tcctcttccg cgcgtccggc
    23881 tacggagtct tggaaaggtc ctagtggagc attcgcccga gccggaacat cgccctggcc
    23941 agagggccgc tccccgccgt cgccgcccgc tccgacgccc ggaccgcggc gaatccgtag
    24001 ccggtcatcc gccgttcgta gtcgccgatc gcgccgtcga gtggcaggcc cgcggcgacg
    24061 gcgccggaca gcgcacggca caggacggcc gcgtcgagca acgcgcagtt ggcccccgag
    24121 ccctgggccg ggctcatcgc gtgaacggcg tcgcccagca cggtgacgtt ggaaggtctc
    24181 cagggcccga cggggacgga gctcctgatc gccacacagg ccgtctgatc cacttcggcg
    24241 gcggccacca gggacaccag gtcggggtgc caggtggaga tgcgccgctt cacgaactcg
    24301 tgcagccctc cggcggccgg cagttcggcg ccggcgcccg gcagctcgcg cgcgtccacc
    24361 gtcagcgccc acatcacgta gtcgcccggc cactgtggac gcagccccgg ccagagcctg
    24421 gcggccgcct ctgccggatc ctcgcgcagc cgcaccagac ccagcgccag gccggcccgg
    24481 cgcgcgtgca ccgacacgaa gccctcgtgc agccgaggag ggagcagggc ggccacccgc
    24541 tcgtcgagca gcgtcctgcc gtagacgcat ctggtgccca gatccttgat ccgcgcatgt
    24601 ggcaggagct gcccgcgtac gcgtgagccg acgccgtcgg cgcccaccag cacgtccccc
    24661 gtgacgctgt cgccgtcggc gaaccaggcg cgcacccgct cgccctcgtg ctcgtagtgc
    24721 gtgaactcgg tgccgtaact gaccacgtcg tccagcccgg ccaggagaac ctggcgcagc
    24781 accatccggt cgaccggagc gctgaaggtc gcggggtcgc cccctgcaga cccaccccct
    24841 gcagatccac cctccgccga cacaccccct gccgacccac cctctgccgg cacgccccca
    24901 gcggagacgc tgtcgaacgt cacggcgtgc acttcccgca ggcgttcgtc gaggacggtg
    24961 acccgcctgc tgggcagccc ggccgtggcg
//
