LOCUS       NZ_BMMN01000004         6949 bp    DNA     linear   CON 22-DEC-2024
DEFINITION  Microbispora bryophytorum strain CGMCC 4.7138 sequence04, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMN01000004
VERSION     NZ_BMMN01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Microbispora bryophytorum
  ORGANISM  Microbispora bryophytorum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 609914)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 202X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645855.1-RS_2024_12_22
            Annotation Date                   :: 12/22/2024 07:39:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,203
            CDSs (total)                      :: 7,136
            Genes (coding)                    :: 7,048
            CDSs (with protein)               :: 7,048
            Genes (RNA)                       :: 67
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1, 2 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 88
            CDSs (without protein)            :: 88
            Pseudo Genes (ambiguous residues) :: 0 of 88
            Pseudo Genes (frameshifted)       :: 16 of 88
            Pseudo Genes (incomplete)         :: 78 of 88
            Pseudo Genes (internal stop)      :: 7 of 88
            Pseudo Genes (multiple problems)  :: 11 of 88
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:18:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 6949
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMN01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..6949
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     gene            <1..617
                     /locus_tag="IEY80_RS12800"
     cand_cluster    1..6949
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..6949
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1679:1949](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1680..1949
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     CDS             <5..617
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=3
                     /inference="COORDINATES: protein motif:HMM:NF025030.5"
                     /locus_tag="IEY80_RS12800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_189104934.1"
                     /transl_table=11
                     /translation="DVRRAALEVLGTGPLDPEVRALALERAAGDDNAVVRRVALEVLGT
                     GPLDPEVRALALERAVGDDDEDVRRAALEVLGTGPLDPEVRALALERAAGDDNAVVRRA
                     ALEVLGTGPLDPEVRALALERAATDQDESVRMQAAITILSFEVDSPALDALEARGGVDR
                     DWMMAMRAHAMSLSPEFVPDSLPDLGLESWWLRGGLTRREK"
     gene            complement(894..1082)
                     /locus_tag="IEY80_RS12805"
     CDS             complement(894..1082)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS12805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_142568187.1"
                     /transl_table=11
                     /translation="MRALAWTCDCRAVVYELLQAGGQAFIRKTTQAEPIPEVEETHRWP
                     IEEARRVWHALLLGEMR"
     gene            complement(1207..1548)
                     /locus_tag="IEY80_RS12810"
                     /old_locus_tag="GCM10011574_25970"
     CDS             complement(1207..1548)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS12810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_25970"
                     /product="hypothetical protein"
                     /protein_id="WP_142568188.1"
                     /transl_table=11
                     /translation="MRQITNGNRTANQQAGILAALGDLLRSRGVRTRLISHITLRMTGF
                     PVQEKAGSELDVYGFGGQVATVTIDQENKPRRFLIKLPKSGTVVPLPSVDQPQSAIRWI
                     VGWANGGAR"
     gene            1680..1949
                     /locus_tag="IEY80_RS12815"
     CDS             1680..1949
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012610.5"
                     /locus_tag="IEY80_RS12815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_076437814.1"
                     /sec_met_domain="TIGR03651 (E-value: 6.3e-05, bitscore:
                     18.4, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEFRPDQLKWEAVLEEIRRRIRTGEYQVGHPIPGEPRMAEEFGI
                     AKGTARRVINELLKAGDVYTVLGKGTFVADPETGGPPRRDTEDE"
     gene            complement(2148..3545)
                     /locus_tag="IEY80_RS12820"
                     /old_locus_tag="GCM10011574_25990"
     CDS             complement(2148..3545)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547010.1"
                     /locus_tag="IEY80_RS12820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_25990"
                     /product="replication initiator"
                     /protein_id="WP_189104935.1"
                     /transl_table=11
                     /translation="MSELPPLSPDVLAAAQRAAMPDFARWQEMVRATGGCAQPIRLQGR
                     RITFDAGLEVLDVYWTADEPTGYLLTACGNRRASRCPACSEVYRDDTYHLILSGLRGGK
                     GVPEDVSAHPRVFATFTAPSFGAVHARRMKGDKVLPCRPRRDNPVCEHGRPEGCGVRHG
                     DDDPRVGQPICGDCYDYRGAVLWNAHAGELWRRFTQALPATFARHLGLSRAALRRRLRL
                     SYAKVAEYQARGLVHFHAVIRLDGPDGPSDRPPYWATVPVLQEAIRETAAAVSVPVPDG
                     DPSFVGRWGTQLDVDPIYVATSLEGIADQRVAAYIAKYATKGAESAGTVDRPIREVSDV
                     VRLDVTEHARRMIYTCFALGNDPAYRLIPLRQWAHMLGYRGHFSTKSRHYSTTLGALRQ
                     VRADHQAERARERRGLPDPAERKTVAVGQWRYAGSGYRNGEYLWAELIRQRIATARRIA
                     RERGESA"
     gene            complement(3542..3697)
                     /locus_tag="IEY80_RS12825"
                     /old_locus_tag="GCM10011574_26000"
     CDS             complement(3542..3697)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS12825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_26000"
                     /product="hypothetical protein"
                     /protein_id="WP_161628146.1"
                     /transl_table=11
                     /translation="MAALAEEWCKRQLERSPRWGVNKWRRLAAIHGAEYVGDAHDTASD
                     SGRDAA"
     misc_feature    complement(4325..4334)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.99"
                     /tool="antismash"
     gene            4519..5739
                     /gene="hemW"
                     /locus_tag="IEY80_RS12830"
                     /old_locus_tag="GCM10011574_26020"
     CDS             4519..5739
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051989 - coproporphyrinogen dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemW"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889011.1"
                     /locus_tag="IEY80_RS12830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_26020"
                     /product="radical SAM family heme chaperone HemW"
                     /protein_id="WP_142568189.1"
                     /sec_met_domain="PF04055 (E-value: 1.3e-23, bitscore: 79.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSVLPDGDPVPPSGELPSEALDGLGSRPFGFYVHVPFCATRCGY
                     CDFNTYTAAELGPGAAQRDYAATAVEEIRLARRVLGDAAPPVETVFFGGGTPTLLPAAD
                     LVRILDAIGEEFGLRPDAEVTTEANPESVDPTYLKELRAGGFTRMSFGMQSAGEHVLAV
                     LDRRHTPGRPAEAVREAHAAGFEHVNLDLIYGTPGESDDDWRASLEAALAAGPDHVSAY
                     SLIVEDGTRLAARIRRGELPMTDDDVAADRYLIAEEMLTAAGLNWYEISNWAAGDEARC
                     RHNLLYWTGGDWWGAGPGAHSHVGGTRWWNVKHPVAYAARLAAGASPAHAREVLRAEDR
                     AVERVMLELRLVSGLPLADIAPEARTACARALADGLFEVEAFKAGRAVLTLRGRLLADA
                     VVRDLTP"
     gene            complement(5903..6706)
                     /locus_tag="IEY80_RS12835"
                     /old_locus_tag="GCM10011574_26030"
     CDS             complement(5903..6706)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131404.1"
                     /locus_tag="IEY80_RS12835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_26030"
                     /product="DUF3097 domain-containing protein"
                     /protein_id="WP_142568190.1"
                     /transl_table=11
                     /translation="MYGRDVLSGDWRRPRRGQIPEIAAEPDLVVEDAEGRFCGAVVACD
                     KEAVTLEDRFGRRRVFPLTPAGFLLDGKPVTLVRPQAGPKGPLRSASGSIAVEGLRAQV
                     ARESRIYVEGVHDASLVEKIWGHDLRVEGVVVEYLEGVDDLPAIVEEFGPEPGRRLGVL
                     VDHLVPGSKESRIAARVSGDDVLVVGHPFVDIWQAVKPRALGIAAWPDVPRGVPWKEGV
                     IDALGWRMDPQETWRHILGRVTTYADLEPELLGRVEQLIDFVTAP"
ORIGIN
        1 aggatgtgcg tcgggcggcg ctggaggtgc tggggacggg gccgctggat ccggaggttc
       61 gggcgctggc attggagcgg gccgctggcg acgataacgc tgttgttagg cgggtggcgc
      121 tggaggtgct ggggacgggg ccgctggatc cggaggttcg ggcgctggcg ttggagcggg
      181 cggtcggcga cgacgatgag gatgtgcgtc gggcggcgct ggaggtgctg gggacggggc
      241 cgctggatcc ggaggttcgg gcgctggcgt tggagcgggc cgctggcgac gataacgctg
      301 tcgttaggcg ggcggcgctg gaggtgctgg ggacggggcc gctggatccg gaggttcggg
      361 cgctggcgct ggagcgtgcc gcaaccgatc aggatgaaag cgtgagaatg caagcagcca
      421 taacgatctt gagttttgag gtcgatagcc ctgcattgga tgcgctagaa gcccgaggag
      481 gagttgaccg ggactggatg atggcgatgc gcgcacatgc aatgtctctc tctccggaat
      541 ttgttcccga tagcctcccg gacctaggtt tggagtcatg gtggttgaga ggtgggctaa
      601 ctcgtcgaga gaaataaccg ctagcgcgag gccggtcaat tcattaagca gaaggatcaa
      661 ccgcccccgc tgctcgattg ttcgtggccc ttggtcggtg tcaacgccgt ctgtgcgggt
      721 tgggtgtggg gctgcggtgt acgtcgttgg tggacggaca cgcgaagacg gcattgacac
      781 ctcggtcggg ccactgatgt cggcagctat cgggggcggg gagaagtggc gcggatcgta
      841 gacagaagtg cggccccgcc cgagtgggcg ggaccgcgtg agtgctgggt cgtctatcgc
      901 atctcgccga gcagcagggc atgccacacc ctgcgggcct cctcgatggg ccaacggtgt
      961 gtttcctcga cctctggtat cggttcggcc tgggtggtct tgcggatgaa cgcctgcccg
     1021 ccggcctgga gcagttcgta gacgacggcc cggcagtcgc aggtccaggc gagcgctcgc
     1081 acgcgcccga ccccctcgaa cggcttatgc cagacgagtt ctacctgatc tcttcggcgc
     1141 atctcccagt gcggactcag gcattcgtcc gggtctacga cgatggcccg catcgcaccc
     1201 gccgcctcac cgtgccccgc cgttggccca gccgacgatc caccggatgg cggactgcgg
     1261 ttggtcgacc gagggcaacg gaaccacggt cccggacttc ggcagcttga tcagaaagcg
     1321 gcgcggcttg ttctcctgat cgatggtgac cgtcgcgacc tgtccaccga agccgtagac
     1381 gtccagctca gagcccgcct tctcctgcac cgggaacccg gtcatccgca gggtgatgtg
     1441 gctgatgagc cgtgtacgga cgcctcggga gcggaggagg tcgccgaggg cggccaggat
     1501 gcccgcctgt tggttggcgg ttcggttgcc gttggtgatc tggcgcatgg ttctcccatc
     1561 tgtctcgctg acgggttgag cgtacgccaa ccttcctagt cctacctagc ccttctccta
     1621 ggtacctcta ggtacctgtg gtaacgacat ggaacgcttt cgttcctact cttgagcccg
     1681 tgatcgagtt ccggcctgac cagctcaaat gggaagccgt cctcgaagag atacgacggc
     1741 gtatccggac gggcgaatac caggtggggc accccatccc tggtgaaccc cgcatggccg
     1801 aggagttcgg catcgccaag ggcaccgcac gccgcgtcat caacgaactg ctcaaggccg
     1861 gagacgtcta caccgtgctc ggcaagggaa ccttcgtcgc cgaccccgag accggcggcc
     1921 cgcccaggag agacaccgaa gacgagtgaa ggcccccgaa cgaatccgga ggccttctgc
     1981 cttctatcgg ttgtcagcga gacgatggaa ggcgcaccaa gcgtagagcc gatgggtcga
     2041 ggtcagtagc gttctgccgt ggcgccgccg gcccaaccgc ttcgcggccc ttcgggtgcc
     2101 tacggcattg cgccagccgc accgctttcg cccacgatct ggcaaggtca ggccgactct
     2161 ccccgttcac gggcgatccg gcgggcggtg gcgatgcgtt gccggatcag ctcggcccac
     2221 aggtattcgc cgttgcggta gccgcttccg gcgtagcgcc actggccgac tgcgaccgtc
     2281 ttccgctcgg caggatcagg taggccgcgc cgttcccgag cccgctcggc ctggtgatcg
     2341 gcccgcacct gccgcagcgc gccgagcgtg gtcgagtagt ggcggctctt ggtcgagaag
     2401 tggccccggt agccgagcat gtgcgcccac tgccgcaacg ggatcagccg gtaggccgga
     2461 tcgttcccca gggcgaagca ggtgtagatc atgcgccggg catgctcggt cacgtccagg
     2521 cgcacgacat cggacacctc tcggataggc cggtccacgg tcccggctga ctctgccccc
     2581 ttcgtcgcgt acttcgcgat gtaggccgcc acccgctgat ccgcgatgcc ctcaagcgag
     2641 gtcgcgacgt agatggggtc cacgtcgagc tgcgtgcccc accggccgac gaacgacggg
     2701 tcaccgtccg gcacgggaac cgagaccgca gccgcggttt cccgaatcgc ctcctggagc
     2761 acgggcacgg tcgcccagta cggcggacga tcggacggcc cgtccggtcc gtcgaggcgg
     2821 atcacggcgt ggaagtggac caggccccgc gcctgatact cggccacctt ggcgtaagac
     2881 agccgaagtc gccgtcgaag cgcggcccgc gagaggccga ggtgccgggc gaaggtcgcc
     2941 ggtagcgcct gggtgaagcg ccgccacagc tcaccggcat gggcgttcca caggaccgcg
     3001 ccccggtagt cgtagcagtc cccgcagatc ggttgcccga cccggggatc gtcgtctccg
     3061 tgccggaccc cgcagccttc cggcctgccg tgctcgcaca ccgggttgtc ccgccgagga
     3121 cggcacggca acaccttgtc tcccttcata cgacgcgcgt ggaccgcgcc gaacgagggg
     3181 gccgtgaacg tggcgaagac gcggggatga gcgctgacgt cctcgggtac gcccttgccg
     3241 ccgcgcaggc cggacaggat caggtggtaa gtgtcgtccc ggtagacctc cgagcaggcc
     3301 gggcaccggg acgcgcgccg gttgccgcac gcggtcagca ggtagccggt cggctcgtcg
     3361 gccgtccagt agacgtccag cacttccaac ccggcgtcga aggtgatccg gcgtccctgt
     3421 agccggatcg gctgggcaca gccgcccgtc gcgcgcacca tctcctgcca ccgggcgaag
     3481 tccggcatgg cggcgcgttg ggcggcggcc agaacatcgg gggagagggg aggaagctcg
     3541 ctcacgcggc gtccctccca ctgtcggagg cggtgtcgtg cgcgtcgccg acgtactcgg
     3601 caccgtggat ggcggcgagc cgccgccact tgttgacgcc ccaccggggc gagcgttcga
     3661 gctgccgctt gcaccactcc tcagccagcg cagccattgg acccagttcc tcgggtacca
     3721 gcggagacct cctttcctcg taggaagccc cctcgcgcga acccgggaaa gacaaagcac
     3781 cagcgcagag cagaccgaag gcaggtctgt agtgcggtgg tgctttcagc gaggcgatat
     3841 gtggagtgtt ttatgcgacg gtgaaccggt gagcacgtcc agggggccta ccgctgggcc
     3901 gggtccctcc agcggaacgg cttatctgtt ttgtcgtttg cccggtggtt cccctgtgct
     3961 cgaatctgtc gcggccggta gctcgctgtt gtgaacgtct ttccgccctg tcgcggacgg
     4021 agcccttgcc ctttcagatg taccacccgg agaacgtatt tagccaggtc agcgttccgc
     4081 gcatggccct tctcgtgact gtccaccgtt gtttgctggc gttcactggc gtccattggc
     4141 gttcgctggc gtatgtctgc agccttgagt ttccccagga aagattggca ccctcgccca
     4201 gggcgctgcg agaatcgccg gatgttcggc tcccgggcgt gcacggcgac tggtctcgat
     4261 ggggaagcga tttgtcatgg cgttgcgcgg cggccgagtg ggggcgcatt agaataaccc
     4321 ggaataacaa attatgcgat attcgggcga gtgtgataaa ggtggatatg gggcccatgc
     4381 acagataggg ccggaaccct cggaagcctg ccgtgatcgt agatcgggtg atcgcgtgat
     4441 cgggttggtc cccgtggtcg ccgtcgtcgg tgatcggggc gtcgagggca gcgcgcgagt
     4501 gacggcagac tggggagcgt gccttcagtg cttcccgacg gcgaccccgt ccccccgagc
     4561 ggcgagttgc cgtccgaggc cctcgacggg ctcggctccc gtccgttcgg cttctacgtc
     4621 cacgtgccgt tctgcgcgac gcgctgcggc tactgcgact tcaacaccta caccgcggcc
     4681 gagctgggcc ctggcgccgc gcaacgcgac tacgcggcca cggcggtcga ggagatccgg
     4741 ctggccaggc gcgtgctggg agacgccgcg ccgcccgtgg agaccgtctt cttcggcggc
     4801 ggcacgccga ccctgctgcc cgccgccgac ctcgtacgga tcctcgacgc catcggcgag
     4861 gagttcggcc tgcggccgga cgccgaggtg acgaccgagg ccaaccccga gtccgtggac
     4921 ccgacctacc tgaaggagct gcgagccggc gggttcaccc gcatgagctt cggcatgcag
     4981 agcgcgggcg agcacgtcct cgccgtcctc gaccggcggc acacccccgg ccgccccgcc
     5041 gaggccgtac gggaggccca cgcggccggg ttcgagcacg tcaacctcga cctgatctac
     5101 ggcacgccgg gggagagcga cgacgactgg cgtgcctcgc tggaggccgc gctggccgcc
     5161 gggcccgacc acgtctcggc gtattccctc atcgtcgagg acggcaccag gctcgccgcc
     5221 cggatccgtc gcggcgagct gccgatgacg gacgacgacg tggcggccga ccgttacctg
     5281 atcgccgagg agatgctgac ggccgcgggc ctgaactggt acgagatctc caactgggcc
     5341 gcgggcgacg aggcccgctg ccgccacaac ctgctctact ggaccggcgg cgactggtgg
     5401 ggggccgggc cgggggcgca cagccatgtc ggcggcaccc gctggtggaa cgtcaagcac
     5461 cccgtcgcgt acgccgcccg cctggccgcc ggggcctcgc ccgcgcacgc ccgcgaggtg
     5521 ctgcgggcgg aggacagggc tgtcgaacgg gtcatgctgg agctgcgcct cgtctcgggc
     5581 ctcccgctcg cggacatcgc ccccgaggcc cgtacggcct gcgcgcgggc gctggcggac
     5641 gggctgttcg aggtggaggc gttcaaggcc ggacgggccg tgctcacgct gcgcggcagg
     5701 ctgctcgccg acgccgtcgt ccgcgatctg accccgtagg acggtcggaa gacggtcaga
     5761 aaatggtcgc agtgagggga tatcggaagc tcttcccgct ccgggcggcg accgcccacc
     5821 ggcgacggct gaccaggtag atcgccggcg tgcccgccat gcccagcggc caagtgcgcg
     5881 gtcaggacgg cgaggcggac gcttatggag ccgtgacgaa gtcgatcagt tgttccacgc
     5941 ggccgagcag ctcgggctcc aggtcggcgt aggtcgtgac ccggcccagg atgtgccgcc
     6001 acgtctcctg ggggtccatc cgccagccga gggcgtcgat cacgccctcc ttccagggca
     6061 cgccccgcgg cacgtccggc caggcggcga tgcccagcgc ccggggcttg accgcctgcc
     6121 agatgtccac gaacggatgc ccgacgacga gcacgtcgtc gccggacacc cgggcggcga
     6181 tgcggctctc cttcgagccg ggcaccaggt ggtccacgag caccccgagc cgcctgcccg
     6241 gctcggggcc gaactcctcg acgatggccg ggaggtcgtc cacgccctcc aggtattcga
     6301 cgacgacccc ctccacccgc aggtcgtggc cccagatctt ctccaccagc gaggcgtcgt
     6361 ggacgccttc gacgtagatg cggctctccc tggcgacctg cgcgcgcagg ccctcgaccg
     6421 cgatcgaccc cgaggcgctg cgcagcggcc ccttcggacc ggcctggggg cgcaccagcg
     6481 tcaccggctt gccgtcgagg aggaatcctg cgggcgtcag cgggaacacc cggcgccggc
     6541 cgaaccggtc ctccagcgtc acggcctcct tgtcgcaggc caccacggcg ccgcagaagc
     6601 ggccctcggc gtcttcgacc acgaggtcgg gctcggccgc gatctcgggg atctgccccc
     6661 gccgtggccg ccgccagtct ccggaaagca cgtcccgccc gtacatgcgg ggaacgctag
     6721 caaatcacgc cgggcggcgg cgggccgtgg agcggcgcgc gagcacgacg acggtcacga
     6781 tcagcgcggc caggaagccg acggtgggca gcgccagcag cgcgacggcg ccgcccgcca
     6841 gcaggccggc cacgccggtg agctgcttgc cgacgccgaa gcgcacctcg tcgccctcgc
     6901 aggagagctg ataggtgccc gcctcgggga caccggcctc gaacagcag
//
