LOCUS       NZ_BMMN01000001        25126 bp    DNA     linear   CON 22-DEC-2024
DEFINITION  Microbispora bryophytorum strain CGMCC 4.7138 sequence01, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMN01000001
VERSION     NZ_BMMN01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Microbispora bryophytorum
  ORGANISM  Microbispora bryophytorum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1141878)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 202X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645855.1-RS_2024_12_22
            Annotation Date                   :: 12/22/2024 07:39:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,203
            CDSs (total)                      :: 7,136
            Genes (coding)                    :: 7,048
            CDSs (with protein)               :: 7,048
            Genes (RNA)                       :: 67
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1, 2 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 88
            CDSs (without protein)            :: 88
            Pseudo Genes (ambiguous residues) :: 0 of 88
            Pseudo Genes (frameshifted)       :: 16 of 88
            Pseudo Genes (incomplete)         :: 78 of 88
            Pseudo Genes (internal stop)      :: 7 of 88
            Pseudo Genes (multiple problems)  :: 11 of 88
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:18:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 421647
            Orig. end                         :: 446773
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMN01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25126
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25126
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25126
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15126](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15126
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    10..25
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.02"
                     /tool="antismash"
     gene            complement(1256..1978)
                     /locus_tag="IEY80_RS02120"
                     /old_locus_tag="GCM10011574_04310"
     CDS             complement(1256..1978)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04310"
                     /product="hypothetical protein"
                     /protein_id="WP_142567698.1"
                     /transl_table=11
                     /translation="MLTVMCSGGHAAGTTTSALALFLEWPRPALLAEADPGGGTILSGY
                     LAGTPRDRGLAEWGVKIRRGVAAAEALWDQLYAIQDGRLILPGLSEPKQATALQPLWPE
                     IAGCLAALDEDVVVDLGQVGRPDTPNDLLVRADRVFVVTRPTLVHLHATTSAIRDVQEL
                     RGHLPDAELIVVGDGQYQLKEIAKTLGATVAAWLPADKWSAPALAHGVGRIRPMSPLVR
                     SARAFAAALVEQSEQVMA"
     gene            complement(1972..2568)
                     /locus_tag="IEY80_RS02125"
                     /old_locus_tag="GCM10011574_04320"
     CDS             complement(1972..2568)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020250.5"
                     /locus_tag="IEY80_RS02125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_04320"
                     /product="SAF domain-containing protein"
                     /protein_id="WP_167748079.1"
                     /transl_table=11
                     /translation="MAVVGVLAVVLSAVTVLQVYQLAAHRTQVLVMARDVPIGQVIEAQ
                     DLSSLGVGVVPGMQWIRTRDRDGVIGKRATADLKAGTLLAPSQLGTALTPDDGQQIVPI
                     ALKATQLPARGLKPGDRVVAAAVPEEGRQGVEYRALVDKVGQPDADGTVVVDFLVPATT
                     GTALARLAAEGKVAMVLASRAAQTRTPTCQPGAPC"
     gene            complement(2647..3504)
                     /locus_tag="IEY80_RS02130"
                     /old_locus_tag="GCM10011574_04330"
     CDS             complement(2647..3504)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04330"
                     /product="hypothetical protein"
                     /protein_id="WP_142567700.1"
                     /transl_table=11
                     /translation="MLSRSLIAGVLPAVSMLTPSPPLDNNGVQTSPLGYVLTADKDPHS
                     GQQVTSASAAHRGSGVTCSYTPWHADGMKNGGLEWVDPASSPGGVPKGKGAYYLIECSD
                     GFRDVRWVPDRAPGAPRVTPAQLARKAWAMIPVREPKVLTAPPRGSTGLVGLDEWVYLA
                     KGEWSPKRKRVETAGVWAEATARPQKMTVDPGDGGKPVTCQGPGTPYNPELPASRQKPT
                     CAVRYLQPSLRQGQGNAYRVTVTVTWSGTWTGSGGTGGTLPPITRSTSFPLRVAEAQAL
                     ITKD"
     gene            complement(3486..4055)
                     /locus_tag="IEY80_RS02135"
                     /old_locus_tag="GCM10011574_04340"
     CDS             complement(3486..4055)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04340"
                     /product="hypothetical protein"
                     /protein_id="WP_142567701.1"
                     /transl_table=11
                     /translation="MALVVVTVCRYSKRLALVVLALSASACAADEGAVPQPSPTVSTTV
                     SPQPGATPTGKAEEAVLAAYKGIYSAGRRAEHTPDGQRKPMIAPFATEPLLSRMLRGIV
                     ALRAGGRFTWGTPVFHPFDIKIEGQKATLHDCQDNRNSGQMDEKTSKRVLHGSENTHLV
                     ATLLLVEGAWKVSTLEHVREACSVGA"
     misc_feature    complement(4281..4296)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.19"
                     /tool="antismash"
     misc_feature    4482..4498
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.15"
                     /tool="antismash"
     gene            4503..5894
                     /locus_tag="IEY80_RS02140"
                     /old_locus_tag="GCM10011574_04350"
     CDS             4503..5894
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04350"
                     /product="hypothetical protein"
                     /protein_id="WP_142567702.1"
                     /transl_table=11
                     /translation="MERQPNTRLADVIDQAGVSHLGLASRIGQVAKEWRVPVRPSHTQI
                     ARWVEGQKPRGVTAALIAEALSRKLGRRVTLADIGLEGSTTSPEIGLNFSDVPADLVDT
                     LAQLVTADAQRREFLRSAVNVGALTQAAFGWLLSTSAQPPSGSAGHRVGMSDVEAIRST
                     TTMFADLDNRFGGAHARSAALQYLLDQIVPLLNGTYTTAVGRSLFSAVAEFCLSVAWMA
                     YDSGWHGLARRYFLQALSLAHHADDRMLGASILSAMSHQATYLGEYREALHLARAAQHD
                     VKGRAPALLRAQFAAMEARAAANLPDGAGECLTALDTAARAFNEHKPGEEPEWIAYFDE
                     SELADEFAHCFRDLGDARESYRHATHCLSVSEASPAAGGYARSRIFSRIVLATSLVDQG
                     DVEQACHIAVRVLPRIQETASVRCTAYLRDLHNRMSAHTDHPAVIEFTEQARPVLRGRR
                     LRAAQ"
     gene            complement(5888..6772)
                     /locus_tag="IEY80_RS02145"
                     /old_locus_tag="GCM10011574_04360"
     CDS             complement(5888..6772)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017583293.1"
                     /locus_tag="IEY80_RS02145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_04360"
                     /product="phosphotransferase family protein"
                     /protein_id="WP_142567703.1"
                     /sec_met_domain="APH (E-value: 2.7e-18, bitscore: 62.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVALLFADIAVKAAREAARRAGFGDQEPEVVRIGDRAVLRLADGH
                     IIARVARSIDRLDSSRREVEVARWLTAEGLTVTRPLEGEQPYIAAGTVVSLWHAVEGDW
                     TVPADLAAVLRRLHALRPPPNLALPELEPLERMDERIESAPTLTAADRLTLRTLTRTLR
                     EDLADVTYVLPRAVIHGDANIGNVLKTSSGEVVLFDLEGLCWGPPEWDLAITAVYRDLG
                     WHTDAEYERFCEVYGFDVTRLPRYQLLRAVRELRMTCWLAQKAGDGEEIATEVRRRIAD
                     LKEPDRPRRWHPY"
     misc_feature    complement(6422..6424)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    7077..7090
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.22"
                     /tool="antismash"
     gene            7549..7872
                     /locus_tag="IEY80_RS02150"
                     /old_locus_tag="GCM10011574_04390"
     CDS             7549..7872
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04390"
                     /product="hypothetical protein"
                     /protein_id="WP_167748080.1"
                     /transl_table=11
                     /translation="MAYLTASRPPGREESAARQVDTHLAATHNIRGGQIHTYRGVALLR
                     LGDLSVWFRAGKISWSTGELGADGKPQTTAFLLHETAQAAVKIAQRYRELRGHVGLHAV
                     RIG"
     gene            7869..8204
                     /locus_tag="IEY80_RS02155"
                     /old_locus_tag="GCM10011574_04400"
     CDS             7869..8204
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04400"
                     /product="hypothetical protein"
                     /protein_id="WP_142567705.1"
                     /transl_table=11
                     /translation="MNVSLLWLVLCLKGIWPPRAGATTTLRFRRVGADSQPQEYRLSVA
                     DTGTRERWTQGDDVLHDGAALMDDLPMQWCDMRVQELIDTGWEFAGVNVDIASISSRAP
                     TSGIATP"
     misc_feature    8214..8233
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.01"
                     /tool="antismash"
     gene            8475..9683
                     /gene="fxlM"
                     /locus_tag="IEY80_RS02160"
                     /old_locus_tag="GCM10011574_04410"
     CDS             8475..9683
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="IEY80_RS02160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_04410"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_142567706.1"
                     /sec_met_domain="PCMT (E-value: 4.4e-46, bitscore: 153.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPHMDAADIPASLRAAMVRELREMDAVTSESVAAALATVPRHL
                     FALGEPLEAAYAANSALVIKRDASGLALSSLSAAHIQAVMLQQAEIEPGMRVLEIGSGG
                     YNAALIQELVGAEGKVVSIDIDPDIVERARACLKTAGYGRVEVVLADAENGVPEQAPYD
                     RIIVTAGAWDIPPAWVDQLSKVGRIVVPLRVRGRTRTIAFDRSDDVLVSRSYCLSAFVP
                     MQGSGSFSEHIVQLAEGVVLQVDEEPQRFDVEALRQALDSPRLERWSGAAFDLPDELEL
                     FLLTNAPQVAMLHASEELVAQGRFAPSATRGVPALISGGSFAYRTKRPNQETGGFESGV
                     FAHGPEAEAVAAKYLELLRRWASDYRRRGAARIQYIPKAARTSLPSRGLISKRHGDVVV
                     SWP"
     gene            9743..9919
                     /locus_tag="IEY80_RS02165"
                     /old_locus_tag="GCM10011574_04420"
     CDS             9743..9919
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="IEY80_RS02165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_04420"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_142567707.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.4e-19, bitscore:
                     64.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIQIENAPATQAGEEDFGEWDLDVSIVESGPAADKLIRMTDDGC
                     GTTCQSACSTTCP"
     CDS_motif       9743..9847
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSIQIENAPATQAGEEDFGEWDLDVSIVESGPAAD"
                     /locus_tag="IEY80_RS02165_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9848..9919
                     /prepeptide="core"
                     /locus_tag="IEY80_RS02165_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-4.70"
                     /molecular_weight="2266.6"
                     /monoisotopic_mass="2265.0"
                     /core_sequence="KLIRMTDDGCGTTCQSACSTTCP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSIQIENAPATQAGEEDFGEWDLDVSIVESGPAAD"
                     /leader_location="[9742:9847](+)"
                     /alternative_weights="2284.6"
                     /alternative_weights="2302.6"
                     /alternative_weights="2320.6"
     gene            10001..13048
                     /locus_tag="IEY80_RS02170"
                     /old_locus_tag="GCM10011574_04430"
     CDS             10001..13048
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="IEY80_RS02170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_04430"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_142567708.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.2e-195,
                     bitscore: 647.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.2e-21,
                     bitscore: 70.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.7e-31, bitscore:
                     105.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYEYLDAVVARAAVWPAHRTPGSWPDMNGKAAGPESWRQWLRETM
                     RMPGFLAALEQASPVLTHRVTEICEGRDVSEPAMRRAVLSVMRYLLRASGRATPFGLFA
                     GIAPARIAALPMAHVGGAHRAVTRVDATWLAGVVERLEAEPALRPHVKVMANNLVSERD
                     GQLVLEHRPAEATRDQPTHVSVRATAPIRTAMSLSRSPIRLGELAEKLVADFPGVPATV
                     VDRLLADLVAQRLLVTNLRPPMTAADPLGHLLSELEEMAAGELAEVAETVGRLRQLAPE
                     LAQHDDAPTSAIARSHRSRLAADMAAVSSVTGSALGVDLRMDLDLAVPQSMAAEAAKAA
                     GVLVRLARRPDLGPGWVAWHGRFLERYGPRALVPVLDAVDPDIGLGYPAGYLGAPSPPS
                     AALSGRDVKLLTLAQKAALCGQHEILLDESTVADLEVAGSEGPIQPTTELTVRVHTPSV
                     RSLSEGEFTLAIIGVSRTAGTTTGRFLHLFDDEERARMCALYTELPTAVRGALRAQISS
                     PALHIETENVARAPRVATHLLPLGEYHDDREGLIALEDLALTADIHRLYLVSRCQRRPV
                     EPFVLNAVEPVKRTHPLVRFLTEVTNALSVPCVSFDWGAATGLPFLPALRYGRTVLSPA
                     RWLLTAADLREGRDWETALKVWRSEVGLPQRVYLGDGDQRLSLDLSEPAHRSLLRAQLE
                     RTGTAVLRASPHPDAAGWIGSHVHEIVVPLVSVRKPARTPEWLGRAEVVTRDHGHLPGY
                     EGRLYLKLYGHPDRQARILIHHLPRLLEELGDQAQWWFLRYQDPEKHLRLRLTVPADSF
                     ALVGDWTRTLRRAGLIARVQWDTDFPETARFGGQAALAAAETYFAADSAAALAQLSASA
                     ERGDPDVRALTAASMFDIVTAMIGDTAESLRWLIEHAAAEPSAPPRALYDQALALANPQ
                     DHRGLAAQPGGVQVVSCWSRRRQALAAYRCALEETGTSPTAVLLPELLHLHHVRMAGTS
                     LQDERVCLHLARAAALSWTARARRRS"
     misc_feature    10340..10342
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10457..10729
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IEY80_RS02170_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.80E-22"
                     /identifier="RREFam001.1"
                     /label="IEY80_RS02170"
                     /locus_tag="IEY80_RS02170"
                     /protein_end="243"
                     /protein_start="152"
                     /score="70.8"
                     /tool="antismash"
                     /translation="VMANNLVSERDGQLVLEHRPAEATRDQPTHVSVRATAPIRTAMSL
                     SRSPIRLGELAEKLVADFPGVPATVVDRLLADLVAQRLLVTNLRPP"
     gene            13045..14280
                     /locus_tag="IEY80_RS02175"
                     /old_locus_tag="GCM10011574_04440"
     CDS             13045..14280
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="IEY80_RS02175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_04440"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_142567709.1"
                     /sec_met_domain="LANC_like (E-value: 9.1e-40, bitscore:
                     132.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGTHSDVMAVGEAVADALSDPGNVWTASSPIGGRAWPQSLAGGA
                     AGIALLHIERARSGLGDWSTAHAWLSVAASQELTAAANAGLFFGAPALAFVTHAAAGSS
                     GRYRRALTTLDEAVITITRTRLAAAHARTDRGDQPVMKEFDLIRGLAGLGAYHLRRHPD
                     HPITQDVLSYLVRLTEPLPSRTELPPWWTNVAPNGKPNPEYPQGHGNFGLSHGIGSVLA
                     LLSLAVLRNVPVAAMTDAIERICAWTDLWRQQDDAGPWWPGFITIDQIREQHIQPSLRP
                     RPSWCYGIAGTARAQQLAGMALGDTTRQQTAEDAMLAAMRDPAQLDLLPEIGLCHGKAG
                     LLQAAWRMAADALTPHIAAELPRLATQLAAQLSRPLSDPELLDGAAGAALALQTVGSDA
                     VASDWDAFLLLA"
     gene            14299..15126
                     /locus_tag="IEY80_RS02180"
                     /old_locus_tag="GCM10011574_04450"
     CDS             14299..15126
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="IEY80_RS02180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_04450"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_142567710.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-39, bitscore:
                     132.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLCPWRQVNVAFPDWATAEQTAVSHLGPLMTEAETEGLITAWFF
                     IRKAPCWRVRYLPGRDAAQADAHLRRRLEDLKSKRHIDDVRHLVYEPETHAFGGPEAMQ
                     VAHELFHRDSRHVLARAAHPSPALGRRETAILLSAVLMRAAGLDWYEQGDVWAKVAEHR
                     PGKASWPPERKAELSQAMHRLLTADVQAMCDAEDAPLAAYRLWVTAFEEAGQALADLAA
                     QGRLLRGLRAVLAHHVIFHANRAGLTSSDQSAIAALAIHTVFNRFSRDGDRHG"
     misc_feature    14848..14850
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15123..16277
                     /locus_tag="IEY80_RS02185"
                     /old_locus_tag="GCM10011574_04460"
     CDS             15123..16277
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04460"
                     /product="hypothetical protein"
                     /protein_id="WP_189104856.1"
                     /transl_table=11
                     /translation="MNQTETFARFPLVARPRPACAPLEARVRHLCDLARSAERSNDRST
                     ASTVFNQAALLASDLGLPELARDWCHQHADIYLRARPLDGTAARHALEPLVNLVRLRIR
                     AGEGTDAFEMLNSLYEAVTTSTDTVIDGLHVPISELTATANDHRELLQWLWTVHLADGT
                     RALTAAGRWQDALDHLRHRNGIGQRMLDGRQVAVIAHTMTGELVPATELLEATQPGEPW
                     EDAVTVCLAVLCRPQGSESEVLPTLLDRYRRLDHAAPGLVMFRTRLGLSVIDALGGVEC
                     PEGRAVADVLIRRVVASQDGYAARELLGHPGFATSLGENGAVALTRILQISGLERGQLP
                     EALMRKLVAALASSSSVIIKGLAVVRPIGDAQLSDVSSKATAYD"
     misc_feature    complement(16319..16333)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.13"
                     /tool="antismash"
     gene            16357..16707
                     /locus_tag="IEY80_RS02190"
     CDS             16357..16707
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021602.5"
                     /locus_tag="IEY80_RS02190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2335 domain-containing protein"
                     /protein_id="WP_142567711.1"
                     /transl_table=11
                     /translation="MFARYEAVLPGAAERILAMTEKVATGHIGNEPKLINAEIETAETG
                     QAIARLLTLVAMTASIVFRHRQLDRGQRLPVVPCRDAHQILPGRQGVVEGAEGHKGAKG
                     EVGVSASTSFCR"
     misc_feature    16949..16958
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            17046..18046
                     /locus_tag="IEY80_RS02195"
                     /pseudo=""
     CDS             17046..18046
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612357.1"
                     /locus_tag="IEY80_RS02195"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTRAQLTDEEWEFIKPYLPIGRFGPYPERLRQQFEGVIWRFRTGG
                     QWREMPQEFGAWPTVHNRFRQWRDAGVFDALLEGAIAEAGRRGEVDLSLVSVDSTTARA
                     HHDAAGMHLGHELFTALEKAAEEEKARQKGATRRDDRSRTP"
     gene            18107..19422
                     /locus_tag="IEY80_RS02200"
                     /old_locus_tag="GCM10011574_04500"
                     /pseudo=""
     CDS             18107..19422
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612232.1"
                     /locus_tag="IEY80_RS02200"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_04500"
                     /product="IS701 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSGGVTAGDLQEWVAGLDALFARVAGRFGRVEPRRQARAYLTGLL
                     APVERKNGWQLAEAAGDATPDRMQRLLVSARWDSLGVRADLRAYVVERLGHRDAVLIVD
                     ETGFIKKGTKSAGVQRQYSGTAGRIENCQLGVFLAYASPLGRALIDAELYLPKSWLADR
                     QRCAQAGIPEEVEFATKPMLARQMLARALDAGLPVSWATADEAYGMDYKFRSFLERRGV
                     SYVVAVPKSQIVAGATVRADTLVADAPPEAWKRRSCGDGAKGPRLYDWALATVHYETEP
                     GYQRWLLARRSLIPGAKGELEIAYYLCYGPVGTTMDDLVRVAGARWAIEECFQTAKNET
                     GLDHYQVRRFDAWHRHITLAMLAHAYLAVTAAHSPKAQAAWSASHQQKSAVSWHT"
     gene            complement(19460..20578)
                     /locus_tag="IEY80_RS02205"
                     /old_locus_tag="GCM10011574_04510"
     CDS             complement(19460..20578)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1229: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017578580.1"
                     /locus_tag="IEY80_RS02205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011574_04510"
                     /product="IS630 family transposase"
                     /protein_id="WP_142567713.1"
                     /transl_table=11
                     /translation="MAEPVRARRLTDHEGQTLQRLVRRGKHGSIRVRRALIIMASASGT
                     PVPAIAQLVAADEDTVRDVIHAFNDRGLDALDPKWAGGRPRLITSDDEAFIIATARTRP
                     EKLGRPFTHWSLRKLAGYLEGNPAHRVRIGRERLRQILHHHKISFQRTRTWKESADPDR
                     EAKLNRIEEVTTRFPTRCFAFDQFGPLSIRPCHGTGWAQRGRPDRLPATYRRTHGIRYF
                     HGCYSLGDDLLWGVTRTRKGGDHTLAALKSIRAARPDGAPIYVILDNLSANKTPAIRAW
                     AAANKVELCLTPTYASWANPIEAQFGPLRSFVMGNSNHPNHTVLARKLQAYLRWRNANA
                     RHPDVLAAQRRERARIRSEKQRRWGRPANEAA"
     gene            complement(20707..21027)
                     /locus_tag="IEY80_RS02210"
                     /old_locus_tag="GCM10011574_04520"
     CDS             complement(20707..21027)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04520"
                     /product="hypothetical protein"
                     /protein_id="WP_142567714.1"
                     /transl_table=11
                     /translation="MDAEQIRDRAEAALTKAGFFVRENDEGIPRDTPFPGGVCLFVQQD
                     QARVYLYPFGFSLEKKSEAAKLAAEALTGEGLQVRALAGESPENELTAADRLLGGTCAL
                     EG"
     misc_feature    21363..21378
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.86"
                     /tool="antismash"
     gene            21425..22027
                     /locus_tag="IEY80_RS02215"
                     /old_locus_tag="GCM10011574_04530"
     CDS             21425..22027
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04530"
                     /product="hypothetical protein"
                     /protein_id="WP_142567715.1"
                     /transl_table=11
                     /translation="MPKDPHKRLLLGAATVSAALLALAAVVADALDSWIPLGVAGALIG
                     LIWLVGVMMLGTDTIVDSEELREVRVLAERLPTDVDLPSGDVFLRIAARHPMDLAIVRV
                     SREGLLDAHLDLQGNSVSTLSYDRFSIGGDNLIARHHAVQKVRRGDSGLLETLPEPDPT
                     FRDLFRYFRFVRSTRALQVTETEIVELRDQLRRALGS"
     misc_feature    21893..21895
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            22453..23655
                     /locus_tag="IEY80_RS02220"
                     /old_locus_tag="GCM10011574_04540"
     CDS             22453..23655
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY80_RS02220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011574_04540"
                     /product="hypothetical protein"
                     /protein_id="WP_142567716.1"
                     /transl_table=11
                     /translation="MLSGRSKFANELATLDPRLRSALGVFDGAILVVDLCIAIARLLID
                     DTDERPWPDRLSDLEDLIEAWQPQLVDALEGMEQLVRDPDAVLRRVKSPGFRDFAHRLL
                     GEATFHRLSSAIKTDGAVLAVGARRGIRKLMPLALALDNCMTFVTAEQFSQIKGFTQFN
                     ESLLRMVLLLDQAMDKVFDLDLPVESVTERIEELEPLVEDTAADITRVADQLHGVITGQ
                     SNEVLLDLSGRLSRKVRGARDALDHSADGVSQAANSLVEFIDRLLREAYDDRTVINWVN
                     STHPEEGDLLYADKDSGRVRPTKRAQTLCFVYGGRAPGDDLFVFNEMAAAGLVATRGRL
                     QKLKHSDDGSQKETQDVRRGIAAVEGFIVYAVRVGWMAMPDEELTAMRVRLGNIRSQSE
                     R"
     misc_feature    22627..22629
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(24073..24087)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 20.98"
                     /tool="antismash"
     misc_feature    complement(24257..24270)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.28"
                     /tool="antismash"
     misc_feature    24520..24533
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.8"
                     /tool="antismash"
     misc_feature    complement(24799..24812)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
ORIGIN
        1 aagcccgcct tgaccagctt gtccatgcac tggggagtga cgttcggtac ggcccgcccg
       61 tccggccctg gtacgaagac ccggttgacg gccgggacga ccgagtcagt cggcggcaga
      121 acctcgaaga tctccgagat gtaccggacg tttatcgggg cgtcggggtc gtggctcacc
      181 tcgtgccgga ggtagacgat gaaatcgacg gccttgccga ccagacggaa cagcgcgtca
      241 gcgggcatgg tcccggcgag gatctccatc cgagggaaga tctcctccgc cgagtcggcg
      301 tgcatggtgc agatcgaccc gcgaccgccg gagttcatcg cgaccagcat cgggaccaac
      361 tcgtcgctgc ggacctcgcc gacgaggatg cggcggccgt tgaagcggaa cgcgtcgtcg
      421 atcagctggc gcatggtgac cgcgccctcg ccctcggagt tggcggcgcg cgcctcgaag
      481 ctgagcacgt cgtggtgccg ctcaggcatc aggtgcagga acagctcgcg ctcgttctcg
      541 acggtgatga gccgctcgaa cgggtcgata tcgccagcaa gagcgcggac cagggtggac
      601 ttgcccgagt tcatcgcgcc cgcgacgatc acgttcatcg ggacgttcat caccgcgtgc
      661 aggaaatgcc ggacgggcca ggacatggtt ccccgggcag ccaggtccga catcgtggcg
      721 tcgagcatgc cgtgcttgcg gatggagaac gccgtgtgcg gggtgatacc ggtcgccgcg
      781 gccagccgta cggtgttgga cagcgccttg tgcaggatcg gcctggcggt ggagaagtcc
      841 ctggcgttct gcccttggta gatgccccag cggcggacgt tctcgatcag ctcgtcctcg
      901 ctgtcggcgg ccggtgggcc agccaccttg cgtccgtcgg tgtaggtcac ccagacctgg
      961 tcgtaccggt tgacgtcgat gttctcgacc gcgggatcgt ccacgagcgg ctgcaaatca
     1021 cccaggtaga agatccggtt ctcgacggcc ttcttgagct gctcctcctc gtccagagtc
     1081 ggagcgggcc ggccgagcag ggcgaggttg tcggcgtagg tgcggacgac gttcgtgatg
     1141 acggccttgc cgtactgcag ggtcgcctcc gcccccgtga cgcccgactc atccagcgcc
     1201 ttgttgacct gctgctgcag ttcgcgtacg gcacggcgga agtcctggtc gtccatcacg
     1261 ccatcacctg ctcactctgc tcgacgagag cggcggcgaa cgcccgtgcg ctacgcacca
     1321 ggggcgacat cggtcggatg cgaccgacgc cgtgcgcgag cgccggcgcg gaccacttgt
     1381 cggccggcaa ccatgccgcg accgtggcac cgagcgtctt ggcgatttcc ttgagctggt
     1441 actggccgtc ccccaccacg atgagctcgg catccggcag atgcccgcgc agttcctgca
     1501 catcgcggat ggcggaggtt gtggcgtgca ggtggaccag cgtgggccgg gtgacgacga
     1561 acacgcggtc ggcccggacc agcaggtcat tcggcgtgtc cggccggccc acctggccca
     1621 ggtcgacgac cacatcctca tccagggcgg ccaggcaacc cgcgatctcc ggccagagtg
     1681 gttggagggc cgtagcctgc ttgggctccg aaaggccggg gagaatcagc ctgccatcct
     1741 gaatggcgta gagctggtcc cacagcgcct cggctgcggc gactcccctg cgaatcttca
     1801 caccccactc ggccaggccg cgatcgcgcg gcgtgcctgc caggtagccg gacaggatcg
     1861 tgccgcctcc gggatccgcc tcggccagca gcgcagggcg cggccactca aggaagagcg
     1921 cgagcgcgct ggtggtcgta ccggcggcat gcccgcccga gcacatcacg gtcagcacgg
     1981 cgcccccggc tgacaggtgg gggtacgagt ttgagcggct ctcgacgcga gcaccatcgc
     2041 gaccttcccc tccgccgcca ggcgggccag agccgtaccg gtcgtggccg gcaccaggaa
     2101 gtccacgacc acggtcccat cggcgtcggg ttgcccgacc ttgtcgacca gcgcgcggta
     2161 ctcaacgcct tgccgccctt cctccggaac ggctgccgcg acgacccggt cgccgggctt
     2221 gagcccgcgt gcggggagct gagtcgcctt gagcgcgatc ggcacgatct gctggccgtc
     2281 atcgggggtg agggccgtgc ccaactggga gggtgcgagg agcgtcccag ccttgaggtc
     2341 ggctgtggct cgcttgccga tcacgccgtc tcggtccctt gtgcggatcc actgcatccc
     2401 cggcaccacg cccaccccga ggctcgacag gtcctgagcc tcgatgacct ggccgatcgg
     2461 cacgtcacgg gccatgacca agacctgcgt gcgatgcgcg gccagttgat acacctgcag
     2521 caccgtgacc gcgctcaaca cgaccgccag aacgccgacg acggccatcg cggggcggcg
     2581 cttacctggc acgggccgtg cggtgggtgg gctgttcgtg gccgctaaag atcgctggag
     2641 catgcatcag tccttggtga tgagtgcctg ggcttccgcg acgcggaggg ggaacgaggt
     2701 cgatcgcgtg atcggcggca acgtgccacc ggtcccgccc gagccggtcc acgtgccgct
     2761 ccacgtgacc gttaccgtga cccgataggc gttcccctgc ccctgacgga gcgacggctg
     2821 gaggtacctc accgcgcagg tcggcttctg gcggctcgcg gggagctccg ggttgtacgg
     2881 cgtgccgggc ccctggcagg taacgggttt gccaccgtca cccgggtcaa cggtcatctt
     2941 ctgagggcgc gctgtcgcct ctgcccagac gccggccgtc tccacccgct tacgcttcgg
     3001 gctccactct cccttggcca ggtagaccca ctcgtccagg ccaacgaggc cggtggagcc
     3061 gcgcggcgga gcggtgagga ccttcggctc gcgcaccggg atcatcgccc acgccttccg
     3121 agccagttga gcgggcgtca cgcgaggagc gccgggcgcg cgatcgggaa cccagcggac
     3181 gtcgcggaag ccgtcggaac actcgatcag gtagtaggcg cccttgccct tcggtacgcc
     3241 tccggggctc gacgccggat cgacccattc caggccgccg ttcttcatgc catcggcatg
     3301 ccagggcgtg taggaacagg tcacaccgga cccacgatga gccgcactgg cgcttgtgac
     3361 ctgctgtcct gagtgcggat ctttgtcggc cgtcaggaca tagcccaaag gcgatgtctg
     3421 aaccccgtta ttgtccagcg ggggcgaggg cgtgagcatc gacacagcgg gcagcacgcc
     3481 cgcgatcagg ctccgactga gcacgcttcc ctcacatgct caagagtcga gaccttccac
     3541 gccccctcaa ccaagagcag cgtcgcgacg agatgggtgt tctcactccc gtgaaggacc
     3601 cgcttcgagg tcttctcgtc catctgtccg ctattgcggt tgtcctggca gtcgtggagt
     3661 gtggccttct gcccctcgat cttgatgtcg aaggggtgga ataccggcgt cccccatgtg
     3721 aatcttccgc cggcccgaag ggcgacgatg ccgcggagca ttctgctcag caggggttcg
     3781 gtcgcgaacg gggcgatcat cggcttgcgc tgcccgtcag gggtatgttc ggcacgccga
     3841 cccgcggagt aaatgccctt gtaggcggca agcaccgcct cctccgcctt tccggtaggc
     3901 gtagcacccg gctgcggtga gacagtcgtc gaaaccgtgg gtgacggctg cggcactgcc
     3961 ccctcatctg ccgcacaagc cgaagccgac agcgcgagaa caaccagcgc aagccgtttc
     4021 gaatatcgac agactgtcac caccaccagc gccatttact cagagcaatc agatcattgc
     4081 ggagagctac aggctagatg gcgaatttca gcgaggccag aggagagaac taaccagtag
     4141 gacacattga ggtagccgca gcgagcgacc tctaccaggg aaaatgtcct tatcggccga
     4201 tgccgtcaac tatcgtgcat ctgcctctct gcccgagaaa caatgggttc gaggtcaccc
     4261 tcggctcggc gctcaggtcc tgtgcgctga tggcgtgggg ccctggcgtg aacggcaggg
     4321 tcggcacgcc tgccgttctt gtccagcagt gctactgccc gtgccgtcca tgacagccaa
     4381 ccgcgcggcg acgccatcgg ggagcgccca cttggtctgc atctgtgcaa agcgctgtgc
     4441 atttcgccct gctcaccgtc atggccttac tgcaaagacc tcgcccaact acgctgcgct
     4501 atatggagcg tcagcccaac acgcggctcg cggacgtcat cgaccaggcc ggtgtctctc
     4561 acctcggcct ggccagccgt atcggccagg tcgcaaagga atggcgcgtg cctgtgcggc
     4621 cttcccatac gcagatcgca cgatgggtcg aaggccagaa gccacgaggc gtcaccgctg
     4681 ctctgatcgc tgaagcgctc agccgcaagc tgggtcgccg ggtcaccctg gcggacatcg
     4741 ggctggaagg cagcaccacc tcaccggaga tcgggctcaa cttctctgac gtccccgccg
     4801 acctcgtcga cacgttggct cagttggtca ccgctgacgc acagcggcga gaattcctgc
     4861 gaagcgcggt gaatgtaggg gccctcaccc aggcggcctt cggatggcta ctgtccacct
     4921 cggcccagcc tccgagtgga tcggcgggtc acagggtggg gatgagcgac gtcgaagcga
     4981 tccgctccac cacgaccatg ttcgccgatc tggacaaccg tttcggcggc gcgcacgctc
     5041 gctcggccgc ccttcaatac ctgctcgacc agatcgtccc gctgctgaac ggcacgtaca
     5101 ccaccgccgt cggacggtcg ctgttcagcg cggtcgccga attctgcctg tccgtggcgt
     5161 ggatggccta cgacagtggc tggcacggcc tcgcccgccg ctacttcctg caggcgcttt
     5221 ctctggctca tcacgccgac gatcggatgc tcggtgccag catcctgtcc gcgatgtccc
     5281 atcaggccac ttacctgggc gaataccgag aggccctcca tcttgctcgc gctgcgcagc
     5341 acgatgtgaa aggccgcgct cccgcactgc tcagagcgca gttcgccgca atggaagccc
     5401 gcgccgccgc caatctcccc gatggagccg gggagtgcct cacggctctc gataccgccg
     5461 ccagggcgtt caacgagcac aagcccggtg aggagcctga gtggatcgcg tacttcgacg
     5521 agtccgagct ggccgacgag ttcgcgcact gcttccggga cctgggggac gccagggagt
     5581 cataccgcca tgccacccac tgcctgtccg tctccgaagc cagtccagcc gccggaggct
     5641 acgcacggag ccggatcttc tcgcggatcg tgctcgccac cagtctcgtc gatcagggtg
     5701 acgtggagca ggcatgccac atcgccgtac gagtcctgcc ccggatccaa gaaaccgcgt
     5761 cggtccgctg cactgcgtac cttcgtgacc tgcataaccg catgagtgct cacaccgatc
     5821 atccagcggt catcgaattc accgagcagg ctcggcctgt gctgcgaggt cgtcggctgc
     5881 gcgcagctca gtaagggtgc cagcgccgcg gcctgtccgg ctccttcagg tcggcgatcc
     5941 tgcggcgtac ctcggtagcg atctcttcgc cgtcgccggc cttctgcgcc aaccagcatg
     6001 tcatgcgcag ttctcggaca gcgcgcagca gctggtaccg gggcagtcgc gtcacgtcga
     6061 atccgtacac ctcgcagaac cgctcgtact cggcgtcggt gtgccacccc agatcccggt
     6121 aaacggccgt gatcgccagg tcccactcag gcggtcccca gcacagccct tccaggtcga
     6181 acagcaccac ctcgccggaa gacgtcttca gcacgttgcc gatgttggcg tcgccgtgga
     6241 tcaccgctcg cggtagcacg tacgtcacat cggcgagatc ctcgcgaagg gtacgggtca
     6301 gcgtccgcaa cgtcagacga tcggctgccg tgagagtggg cgcggactct atgcgctcat
     6361 ccattcgctc gagcggttcc aactcgggca acgcgaggtt aggcggaggc cgaagggcgt
     6421 gtaagcgtcg caacaccgcg gcgaggtcag ccgggacagt ccagtcgccc tccaccgcgt
     6481 gccacagaga caccaccgtt ccggctgcga tgtacggttg ctcaccctcc aggggccgag
     6541 tgaccgtgag cccctcagcc gtcagccacc gagcgacctc aacctcacga cgagacgaat
     6601 ccagccgatc gatgctcctg gcaacgcggg cgatgatgtg tccgtcggcc agccgcaaca
     6661 cggcgcgatc cccgatacgg acaacctctg gttcttgatc accaaacccg gcgcgccggg
     6721 cagcctcacg cgcggccttg acagcgatat cagcgaacaa cagggcgacc acccatcaga
     6781 tgctttcctt cgttccgctc accgcacgca ctgctcgcgg cgactggcca ggccgaggtg
     6841 gggacgccag ccatttcgat gacgtcggcg agcccgagtg ccggactgac gatccacagg
     6901 ccgcagcgta gttggggctc cgtccctgca gtaaggccct ggtggcgggc agctcgaatg
     6961 cacagcggtt tgcacagatg cagagtcgct gagcgctccc gggcgccgtt cccgcgcggt
     7021 tggctgtgag tcatggacaa cacgcacagc agttcgctgc tggacgagaa cggcgaggca
     7081 tcgcccttgc cgttcactcg acgggctcag ccggcccgtc gctatccgca cccctcggcc
     7141 tgatgggagc agagccagcc cccggcgtct gacacgtcca tgggagatcg tctatgtcaa
     7201 catcccaccc cgcggcggag cccttggagg cgctggctga ggagttgcga agccggaact
     7261 tctccgctcg actcgtcgcc cctctcaatc gcatcccccg gcttcaggtg ataaaccccg
     7321 cggctccggc gcttacggag caggttctcg ccaagcccga ttcagacgga gcctggcact
     7381 actggttccc gtggccggcg ctcatcgctg ctgtcgacga catcccgact gcggccgatc
     7441 gcatcgaacg cgtcctcgcc gaggtcggcc gaaacaccgg cggcgcgcct ggagccgacg
     7501 cccccgaagg cctcgcctcg tccgcccgta cctgttcagg agaactacat ggcatacctg
     7561 actgcctcga gaccaccggg gcgtgaagag tccgccgctc ggcaggtgga cacccacctc
     7621 gcggccacgc acaacatccg tggcgggcag atccacacgt accgaggggt cgcgctcctc
     7681 cgcctcggcg acctgtccgt ctggttccgt gcggggaaga tctcctggag caccggagag
     7741 ctcggtgcgg acggcaagcc ccagacgacc gccttcctcc tgcacgagac cgcacaggcg
     7801 gccgtcaaga tcgcccagcg ctaccgggaa cttcgcggac acgttggcct tcacgcggta
     7861 cggatcgggt gaacgtgtcg ctgctctggc ttgtgctgtg cctcaagggc atctggccac
     7921 ctcgggcggg tgccaccacg acgctgcggt tccgacgggt gggggccgac agccagccgc
     7981 aggagtaccg gttgagtgtc gccgataccg gcacacgcga acgctggaca cagggcgacg
     8041 acgtactgca tgacggagcc gccctcatgg acgacctccc gatgcagtgg tgtgacatgc
     8101 gcgtgcagga gctcattgac actggctggg agttcgccgg cgtgaacgtc gacatcgcgt
     8161 cgatatccag ccgagccccg acgagcggaa tcgccacccc atagccctcg gcggcgcggt
     8221 cgagtgcccc tcgcccacag gggcagcccc cgtctcccgc accgtcgagc atccggcccg
     8281 gcccagaacg tacccgcatg caacgcctgg gccgggccgt ggacgacgtg gcgtcagctc
     8341 gtaccggcgc ccccgcaaga ccggccgcct acggcctcag aagtttggcg aggaggccac
     8401 atgacctgtg ccgagggacc acgatcaccg gggcggcgag cccgtcgcct cgtcaacctc
     8461 cgaaggaagc gctgatgact acaccgcaca tggacgcggc cgatatccct gcctcgctgc
     8521 gggccgccat ggtgcgcgag ctgcgtgaga tggacgcggt cacatcggag tccgtggccg
     8581 cggccctcgc caccgtaccc aggcacctgt tcgccctggg ggagccgctg gaggcggcgt
     8641 acgccgcgaa cagtgccctg gtgatcaagc gggacgcgag tggcctcgct ctgagctctc
     8701 tgtcggccgc ccacatccag gcggtgatgt tgcagcaggc cgagatcgaa cccggcatgc
     8761 gggttctgga gatcggctcg ggcggttaca acgccgctct gattcaggaa ctcgtcggag
     8821 ccgagggaaa ggtcgtttcg atcgacatcg accccgacat cgtcgagcgc gcccgcgcct
     8881 gcctcaagac agccggctac ggccgtgtcg aggtggtgct ggccgacgcc gagaacggcg
     8941 tgccggagca agcgccgtac gaccggatca tcgtcaccgc gggggcctgg gacattcccc
     9001 cggcgtgggt ggaccaactc tccaaagtcg gcaggatcgt cgtcccgctg cgggtgagag
     9061 ggcggacccg caccatcgcc ttcgaccgca gcgacgacgt cctggtgagc cgcagctact
     9121 gcctgtcggc cttcgtgccg atgcaggggt ccggttcatt cagcgagcac atcgtgcagc
     9181 tcgccgaagg ggtcgtgcta caggtcgatg aagagccaca gcggttcgac gtcgaggcgc
     9241 tgcggcaggc actcgactcc cccaggctgg aacgctggtc aggggcggcc ttcgacctgc
     9301 ccgacgagct ggagctgttc ctcctcacca acgcgccgca ggtcgccatg ctgcacgcca
     9361 gcgaggaact cgtcgcacag gggcgtttcg ccccctcggc gacgagaggc gttcctgccc
     9421 tcatcagcgg cggcagcttc gcctaccgga cgaaacggcc gaaccaggag accggcggtt
     9481 tcgaaagcgg cgtcttcgct cacggccccg aagccgaggc cgtcgcggcg aagtacctgg
     9541 aactgctgcg gcgatgggca agcgactacc gccgccgcgg cgccgcgcgc atccagtaca
     9601 tcccgaaggc tgcccgtacg agcctcccct cccgagggct catcagcaag cggcacggag
     9661 acgtcgtcgt ctcctggccc tgaagcgccc ggctcccagc agggagaacc gggaatcttg
     9721 caccaccacg aaggaggttc tcatgtccat tcagatcgag aacgcaccgg ctacgcaggc
     9781 cggagaggag gacttcgggg agtgggacct ggacgtctcg atcgtcgagt ccggcccggc
     9841 cgccgacaag ctcatccgga tgaccgacga cggctgcggg acaacctgcc agtccgcctg
     9901 ctcgaccacc tgcccgtaag cgcctgacgc ctcgaccctc tgaaccccgg gcgcccggtc
     9961 gccgcgccga ccgggcgctt tccgtctccg ggagcggcac atgtacgagt atctcgacgc
    10021 tgtcgtggcg cgagccgccg tctggccggc gcaccgcacg cccggctcat ggccagacat
    10081 gaatggaaaa gcagccggac cagagtcctg gcggcagtgg ttgcgagaga ccatgcggat
    10141 gcccggcttc ctggccgcgt tggagcaggc cagccccgtt ctgacgcacc gagtgaccga
    10201 gatctgtgag gggcgggacg tctctgagcc tgccatgcgc cgggcggtgc tctcggttat
    10261 gcgctacctg cttcgtgcct caggacgtgc gacgccgttc ggcctgttcg ccggtatcgc
    10321 cccggctcgc atcgccgcct tacccatggc ccacgtcggt ggcgcccatc gcgccgtaac
    10381 cagggtcgac gccacgtggc tggcgggtgt cgtcgagcgc ctggaggccg aaccggcgct
    10441 gcgaccgcat gtgaaggtga tggccaacaa tctcgtgtcc gagcgtgacg gccagctggt
    10501 gttggagcac cgtcccgccg aggcgactcg cgaccagccg acccacgtga gcgtacgcgc
    10561 caccgcgccg atccggacgg ctatgagcct gtcccgcagc ccgatccggc tgggggagct
    10621 ggcggagaag cttgtggctg acttcccggg cgtccctgcc actgtcgtgg accgcctgct
    10681 ggcggacctg gtggcacaac gcctgctcgt caccaacttg cgccccccga tgaccgcagc
    10741 cgatcccctc ggccatctcc tgtctgaact cgaggagatg gcagccggag agctcgctga
    10801 ggtggccgag actgtcgggc gtctacgcca gctcgctccg gaattggccc agcacgacga
    10861 tgctcccacc tcagcgatag cgcgcagcca tcgctcgcgc cttgccgccg acatggccgc
    10921 cgtctcctct gtaacggggt ccgcactcgg cgtcgatctg cggatggacc tggaccttgc
    10981 ggtgccgcag tcgatggccg ccgaggcggc gaaggccgcc ggcgtgctcg tacggctcgc
    11041 ccgtcgccca gacctcggcc ccggctgggt cgcctggcat ggccgtttcc tggagcgcta
    11101 cgggccgcgg gccctggtcc ccgtcctcga cgccgtcgat ccggatatcg gactcggata
    11161 cccggccggc tacctgggcg caccgtcgcc gccttcggcc gcgctgtccg ggcgggacgt
    11221 gaagctgctg acgctggcgc agaaggccgc gctgtgcggc caacacgaga tcctgctgga
    11281 tgagtcgacg gtggcagatc tggaggtcgc aggttctgag gggcccattc agcccactac
    11341 cgaactaacc gttcgcgtcc acactccaag cgttcgctcc ctgagcgaag gcgagttcac
    11401 cctcgcgatc atcggtgtgt cgcgtacggc cggcaccacg accgggcgat tcctgcacct
    11461 gttcgacgac gaggaacgcg cgcggatgtg cgcgctctat acggagttgc ccaccgcggt
    11521 ccgcggcgcg ctcagagcgc agatctcttc tcccgctcta cacatagaga cagagaacgt
    11581 cgcccgcgcc cctcgcgtag cgacacatct gctccctctg ggcgagtacc acgacgaccg
    11641 cgaagggctc atagcgctgg aggacctcgc cctcaccgcg gacatccacc gtctctacct
    11701 tgtctctcgc tgtcagcgtc gcccggtgga acctttcgtg ctgaacgcgg tggagccggt
    11761 caagcgcact catccgctgg tccggttcct gaccgaggtc acgaacgcgc tcagtgttcc
    11821 gtgcgtctcg ttcgactggg gagccgccac cggcctgccg ttcctcccag cgctgcgcta
    11881 cggacgtacg gtcctgtccc ccgcccgctg gttgctcacc gccgccgacc tgcgcgaagg
    11941 gcgggactgg gagacggctc tgaaggtctg gcgatccgag gtcggcctgc cgcagagggt
    12001 ttacctcggc gatggcgatc aacgcctcag cctggacctg tccgaacccg cccaccggtc
    12061 actgctgcgc gcccaactgg agcgaaccgg caccgcggtg ctacgagcca gcccccaccc
    12121 ggacgcggcg ggatggatcg gcagtcatgt gcacgagatc gtcgtgccat tggtctccgt
    12181 tcggaagccc gcgaggacgc cggaatggct cggcagagca gaagtcgtca ctcgcgacca
    12241 cggccacctt cctggctacg agggacgcct ctatctcaag ctgtacggtc acccggaccg
    12301 gcaagccaga atcctcatcc accacttgcc gcgcttgctc gaagagctgg gtgaccaggc
    12361 ccaatggtgg ttcctgcgct accaggaccc ggaaaagcac ctgcgcctgc ggctgacggt
    12421 gcccgccgac agcttcgcgc ttgtaggcga ctggactcgt acgcttcgcc gcgccgggct
    12481 gatcgcgcgc gtgcagtggg acaccgactt ccccgagacg gcccgctttg gcggccaagc
    12541 ggcactggca gcggccgaga cgtacttcgc cgcggactcg gccgcggccc tcgcgcaact
    12601 gagcgccagc gccgagagag gcgaccccga cgtacgcgct ctgaccgcgg cgagcatgtt
    12661 cgacatcgtc accgcaatga tcggcgacac tgccgagtcg ctgcgctggc tgatcgaaca
    12721 cgccgcggct gagccctctg ccccgccccg cgcgctctac gaccaggccc tcgcgctggc
    12781 caacccacag gatcaccggg gcctggccgc tcagcccgga ggcgtacagg tcgtctcctg
    12841 ctggtctcgg cggcggcaag cgctggccgc ctaccggtgc gcactcgagg aaaccgggac
    12901 gagcccaacg gccgttctgc tgcccgagct tctgcatctg caccacgtcc gcatggccgg
    12961 gacctccctg caggacgagc gcgtctgcct acatctggcc cgtgccgcag ccctgagttg
    13021 gacagcccga gcaaggagac gatcatgatt ggaacccact ccgacgttat ggccgtgggc
    13081 gaggccgtag ccgacgcgct gtcggacccg gggaacgtgt ggaccgcttc ctctccgatc
    13141 ggagggcggg cgtggccgca gtcgctggcc ggtggcgcgg cgggcatcgc cctgctgcac
    13201 atcgaacgcg ctcgttccgg cctcggcgat tggagcactg cccacgcctg gctgtcggtg
    13261 gccgcctccc aagagctgac cgcggcggcc aacgcgggcc tgttcttcgg cgccccagcc
    13321 ctcgccttcg tcactcacgc agccgccggc tcgtcgggca gataccgccg ggcactgacc
    13381 accctggacg aggcggtcat caccatcacc cgtacgcgcc tggcggcggc gcacgcacgc
    13441 accgaccgag gcgaccagcc cgtgatgaag gagttcgacc tgatccgcgg actggccggt
    13501 ctgggcgcct accacctgcg acgccacccg gaccacccga tcacccagga cgtactgtcc
    13561 tacctggtgc gtctgaccga accgctgccc tcgaggactg agcttccgcc atggtggacg
    13621 aacgtcgcgc ccaacggtaa gccgaacccg gaatacccgc aagggcacgg gaacttcggc
    13681 ctgtcccacg gcatcggctc ggtcctggcc ctactgtcgc tggccgtact gcgcaacgtg
    13741 cccgtcgcgg cgatgaccga cgcgatcgag cggatctgcg cgtggacgga tctctggcga
    13801 cagcaagacg atgcgggacc gtggtggccc ggcttcatca ccatcgacca gatccgcgag
    13861 cagcacattc agccgtcgct gcgcccccgg ccctcgtggt gctacgggat cgccggtacc
    13921 gcccgcgcgc agcaactggc cggcatggcg ctcggagaca ccacgcggca gcagaccgcg
    13981 gaggacgcga tgctcgccgc catgcgtgat cctgcacaac tcgatctgct ccccgagatc
    14041 gggctctgtc acgggaaggc cgggctactt caagccgcct ggcgaatggc cgccgacgcc
    14101 ctcaccccac acatcgctgc cgaactcccc cgcctggcaa cccagctcgc cgctcagttg
    14161 agccgtccgc tgtccgaccc cgaactcctc gatggggccg cgggggccgc actcgccctg
    14221 cagaccgtcg gctccgacgc cgtcgcgtcg gactgggacg ccttcctctt gctggcctga
    14281 acacaggagc tgaccccgat ggacctctgc ccatggcgtc aggtcaacgt cgcctttcca
    14341 gactgggcca cagccgagca gaccgccgtg tcccacctcg gtcccttgat gaccgaggcg
    14401 gagaccgaag ggctaatcac cgcctggttc ttcatccgca aagcaccctg ttggcgcgtg
    14461 cgctacctac ccggccgtga cgctgctcag gccgatgccc acctgcgtcg tcgtcttgag
    14521 gacctcaaga gcaagcggca catcgacgac gtcaggcacc tcgtctacga accggaaacc
    14581 cacgccttcg gcggtccaga ggccatgcag gtcgcccacg agctgtttca tcgcgacagc
    14641 cgccacgtac tggctcgcgc cgcccacccc tcccccgcac tcggacgtcg ggagacggcg
    14701 attctgctgt ccgccgtgct gatgcgcgcc gctggcctcg actggtacga gcagggcgac
    14761 gtctgggcca aggtcgccga gcaccggccc ggcaaggcgt cctggccgcc agagcgcaag
    14821 gccgaactgt cccaggccat gcaccgctta ctgaccgcgg acgtgcaagc tatgtgtgac
    14881 gccgaggacg ctccgctggc cgcctaccgc ctgtgggtga ccgccttcga ggaagccggg
    14941 caagccctgg ccgacctcgc cgctcagggc cggctgctgc gcggcctccg cgctgtcctc
    15001 gcccaccatg tgatcttcca tgcgaaccgg gcgggactaa cgagcagcga tcaatccgct
    15061 atcgccgcgc tcgcgatcca cacggtgttc aacaggttct cccgagacgg ggataggcac
    15121 ggatgaatca gacagagacc ttcgcgcggt ttccgctcgt cgcccggccc cgcccggcct
    15181 gcgccccact cgaagcacgc gtacggcacc tgtgcgattt ggcccgctca gccgaacgca
    15241 gcaacgatcg atcgacagcc tcgaccgtct tcaaccaggc cgccctcctg gccagcgacc
    15301 tcggcctccc cgaactggcc cgggactggt gccaccagca cgccgacatc tacctgcgtg
    15361 cgcgcccact cgacggtacg gccgcccgcc acgccctcga acccctcgtc aacctcgtcc
    15421 gtctgcgcat ccgcgccggc gaaggcaccg acgcgttcga gatgctcaac agcttgtacg
    15481 aagctgtcac gacgagcacc gacaccgtca tcgatgggct gcacgtgccc atatccgagc
    15541 tcaccgccac agcgaacgat catcgggagc tcctccagtg gctgtggacc gtccatctcg
    15601 ccgacggcac tcgcgccctg acggccgcag gccgatggca ggacgccctc gatcacctgc
    15661 gccaccgcaa cggcatcggc cagcgcatgc tcgacggccg ccaggtcgcc gtcatcgcgc
    15721 acaccatgac cggcgagctc gtcccggcta cggaattgct ggaggccacc cagcccggcg
    15781 agccatggga agacgccgta accgtatgcc tggccgtgct ctgccgacct caaggttcgg
    15841 agagcgaggt cctccccacg ctgctggacc gctatcggag gctcgaccac gctgcgcccg
    15901 gcctggtcat gttccgtacc cggcttggtc tgtcagtaat cgacgccctc ggcggcgtgg
    15961 aatgtccgga gggacgcgcg gtggccgacg tactgatcag gcgggtggtg gcgtcccagg
    16021 atggctatgc cgcccgagaa ctgctcgggc accccggatt cgcgacgtcg ctgggagaga
    16081 atggcgccgt cgctctcacg cgcattctcc agataagcgg actggaacgt ggacagctgc
    16141 cggaggcact catgcgcaag ctcgtagccg cactggccag cagtagctca gtgatcatca
    16201 agggcctcgc cgtggtgaga cctataggcg acgcgcagct atccgacgtt agtagcaaag
    16261 cgaccgccta tgactaaggg cctcgaagta gaagagcccg aggccagtca gttcgtcttg
    16321 gaaagattct tccagggccc gctgccgccc ccttaggtgt tcgcccggta cgaggcggta
    16381 cttccgggag ccgccgagcg cattctcgct atgaccgaga aggtcgcgac gggtcacatc
    16441 ggcaacgagc cgaagctgat caacgcggag atcgagaccg cggagaccgg gcaggcgatt
    16501 gcccggcttc tcaccctcgt ggcgatgacc gcgtccatcg tttttcgcca tcggcaactt
    16561 gatcgcgggc agcgtcttcc tgtcgttccc tgtcgtgatg ctcatcaaat ccttcctggg
    16621 cggcagggcg tcgtcgaagg agccgaagga cacaaaggag caaaaggaga agtaggggta
    16681 tcggcctcta cgtcgttctg tcggtgacta ggtctgctgt ccggcttggg tccgctcggt
    16741 cccatcagcg ccgtctccca cacgggggat ggcgctttcg tcataccccc agtccctgcg
    16801 ccgccgctgc tcccgggtga ctcacaccag atcggcgtat aggcggtcgt cggcggtctt
    16861 cctcatgccg gccatcctga cgcctccacg cgagccccgc catccggtat gcaggatcct
    16921 cgaaaccgga aagccgcctc ccgacccgga aggcggcgtt tcgcgcgact agggcgcgta
    16981 tcgggttgtg atcaatctgt gggattcgcc tgtctgccgt ggcctgatcc ggtagatcgg
    17041 cgtgtatgac gcgtgctcaa ctgacggatg aggagtggga gttcatcaag ccttatctgc
    17101 cgatcggcag gttcggcccg taccccgagc ggctgcggca gcagtttgag ggtgtgatct
    17161 ggcggttcag gacgggcggg cagtggcggg agatgccgca ggagttcgga gcctggccga
    17221 ccgtccacaa ccgcttccgg cagtggaggg atgccggcgt cttcgacgcc ctgctggaag
    17281 gggcgatcgc ggaagccggc aggcgcggcg aggtggattt gtccctggtc agtgtggact
    17341 ccaccaccgc ccgggcgcac cacgacgctg cggggatgca cctcggccac gagcttttca
    17401 ccgcgctgga gaaggccgcc gaggaggaga aggcccggca aaagggggcg actcggaggg
    17461 acgacaggag cagaacgccg taaacgaccc cggagcagaa gaacggcgac atatccggca
    17521 tcggcgcagg ctccggttga aagccgccct gctcggacgg tccaggggcg ggcagaccag
    17581 caagattcac cttgccgccg accgcaagtg ccgcccgctg gcgttcgtct tgaccgcggg
    17641 acaggccgcc gacagcccgc agttcatccc cgtgctcaag aaagtacgcg tccgggtgcc
    17701 cgtcggccgt ccccgcaccc ggcccgacgc ggtcgccggc gacaaggcct actcctcccg
    17761 cggcaaccgc gcctacctac gcagacgtcg catcaaggtg gtcatcccgg aaaagaggga
    17821 ccaggccgcc aaccggaaga agaagggcag caagggcggc cggcccatca gccacgacgc
    17881 cgacctgtac aaagagcgca acaccgtcga gcgcctgatc aacaagctca aggcctggcg
    17941 aggcatcgct acccgctacg acaaaacccc cgcgagctac ctcgccggcc tccacctccg
    18001 cgccgcgatg atctggatca aagacctcac ccggaccacc ccctgatcac aaccaaatac
    18061 acgccctagt actacagcca ggttttgtga tctatagttc tggatcatgt cgggtggtgt
    18121 gactgcgggc gaccttcagg agtgggtggc cgggctggat gcgttgttcg cgcgggtggc
    18181 gggtcggttc gggcgggtgg agccgcggcg tcaagcgcgg gcgtatctga ccggtttgct
    18241 ggctccggtg gagcggaaga acggctggca gttggccgag gcggccgggg acgcgacacc
    18301 ggatcggatg cagcggttgc tggtcagcgc ccgctgggac tccctggggg tacgggcgga
    18361 tctgcgggcg tacgtggtgg aacgcctcgg gcaccgggat gcggtgctga tcgtggacga
    18421 gaccggcttc atcaagaagg gcacgaagtc ggccggggtg cagcgtcagt actccggcac
    18481 ggcgggccgg atcgagaact gccagctcgg tgtgttcctg gcctacgcct caccgctggg
    18541 ccgggcgttg atcgatgcgg agttgtacct gccgaagtcc tggctggccg accgccagcg
    18601 gtgtgcgcag gccggcatcc ctgaggaggt ggagttcgcc accaagccga tgctcgcccg
    18661 gcagatgctg gcccgggcct tggacgctgg cctgcccgtg tcttgggcga cggccgatga
    18721 ggcctatggc atggactaca agttccgctc tttcctggag cggcgcggtg tcagctatgt
    18781 ggtcgccgtc ccgaagagtc agatcgtcgc gggtgccacc gtacgcgccg ataccctcgt
    18841 cgcggacgcc ccgccggagg cgtggaagcg ccgctcgtgc ggcgatggcg caaaagggcc
    18901 ccggctgtat gactgggcgc tggccaccgt gcactacgag accgagcccg gctaccagcg
    18961 ctggctgcta gcccggcgct ccctgatccc cggcgccaaa ggtgaactgg agatcgccta
    19021 ctacctgtgc tacggcccgg tgggaacgac gatggacgac ctggtccgcg tggccggagc
    19081 gcgctgggcg atcgaggaat gcttccagac cgccaagaac gagaccggcc tggaccatta
    19141 ccaggtccgc cggttcgatg cctggcaccg ccacatcacc ctcgcgatgc tcgcccacgc
    19201 ctacctcgcc gtcaccgccg cacactcccc aaaagcccag gcggcctggt ccgcctcaca
    19261 ccagcagaaa tccgccgtct cctggcacac gtgatcgtcc ctgccgcacg cgctcttgag
    19321 tctgtattgg cctggtcaac ccaccgacgc gaccatcaga cccgcgcccg ccacagccac
    19381 tactggcgac gctggctcag acatcacgaa atcaggctgt agtactaggt gcggtgacca
    19441 cgaacgttcg ccgggttggt caggcggctt cgttggcggg tcgtccccag cggcgttgtt
    19501 tctcgctgcg gatgcgggcg cgttcgcgtc gctgggcggc gagcacgtcg gggtggcggg
    19561 cgttggcgtt gcgccagcgc aggtaggcct gcagcttgcg ggccagcacg gtgtggttgg
    19621 gatggttgga gttgcccatc acgaagctgc gtagcggccc gaactgcgcc tcgatggggt
    19681 tggcccagga ggcgtaggtc ggggtgaggc acaactcgac cttgttagcc gcggcccagg
    19741 cgcggatcgc gggggtcttg ttggccgaca ggttgtccag gatcacgtag atcggggcgc
    19801 cgtcggggcg ggcggcacgg atggacttca gcgcagccag agtgtggtca ccgcccttgc
    19861 gcgtgcgggt gacgccccac agcaggtcat cgcccaggct gtagcagccg tggaagtagc
    19921 ggatgccgtg cgtgcgccgg taggtagccg gcagtcgatc gggccggccc cgctgcgccc
    19981 aaccggtgcc gtggcagggc cggatcgaca acggtccgaa ctggtcgaag gcgaaacacc
    20041 gggtcgggaa gcgggtggtg acctcctcga tccggttcag cttggcttcg cggtcggggt
    20101 cggcggactc cttccacgtg cgggtccgct ggaaggagat cttgtggtgg tgcaggatct
    20161 gccgcagccg ctcccgcccg atccggacgc ggtgggcggg gttgccctcc aggtagccgg
    20221 ccagcttgcg caggctccag tgggtgaacg ggcggcccag tttctccggg cgcgtgcggg
    20281 ccgtcgcgat gatgaacgcc tcatcgtcgc tggtgatcag gcggggacgg ccacccgccc
    20341 atttagggtc cagcgcatca agcccccggt cgttgaaggc gtgaatgaca tcccgcacgg
    20401 tgtcctcatc ggcggccacc agttgggcga tggccggcac cggcgtaccg ctggccgagg
    20461 ccataatgat cagagcccgg cggacccgga tcgagccgtg cttgccccgc cggaccagac
    20521 gttgcagcgt ctgaccctcg tggtcggtca atcgccgcgc tcgtacgggc tcggccatcc
    20581 gctcctccta ccgtcggtac cgatcactgg taccgacagt ggaggcaaac ccgatcaaag
    20641 gcccggaagc ggcccggtgt gtcgccaccc ggcgaaccta agtggacatc ccactagggc
    20701 aggactctaa ccctcaaggg cgcaggtgcc cccgagcagg cggtcggccg cagtcagttc
    20761 gttctccgga gattcaccgg caagggcccg gacctgaagc ccttcgccag tcagagcctc
    20821 cgcagcgagc ttggccgcct ccgacttctt ctccagggag aacccaaacg ggtagagata
    20881 cacgcgggcc tggtcctgct gcacgaagag gcagactcct cccgggaagg gtgtgtcccg
    20941 ggggatgccc tcatcgttct cccgtacgaa gaacccggcc ttcgtgagag cggcctcagc
    21001 ccggtcccta atctgctctg cgtccacgct gacgctccca tcgctggtgt tgctgatgca
    21061 ggtgggacgt cccggggccc acggcgggtt ccccgggtcg tgtccctagg atcgccccgt
    21121 gacagcgcac cacccggggg actgatggcc ggcaacgaca cccctgacga cctgctcgcg
    21181 ctgcagcgcg cctatgaaca ggcgacggca aggtgcagga actatcgggg gggatgagca
    21241 ccgcgaggtg ctgaaggacg cgagagcaga gaggctccgc ctcgtcgagg aactccaccg
    21301 ccacccgttc tggtggacaa ccaccacgcc cctggcacgg cgctcaagcg agcctcgagg
    21361 acctgacact ttcctcaccg gcgggcgcct accggagata cggaggtgaa ggcacagtgt
    21421 ggctgtgccc aaggaccccc acaagcgcct gctcctaggc gcggccaccg ttagcgctgc
    21481 gctactcgcc ctggccgcag tcgttgcaga tgctctcgac agttggatac cactaggagt
    21541 ggctggcgcc ctgatcggcc tcatatggct agtcggcgtg atgatgctcg gcaccgacac
    21601 catcgtggac tcggaggagc ttcgtgaggt tagggtgctg gcggaaaggc tccccacgga
    21661 cgtcgacctt ccgagcggcg acgtcttcct cagaattgca gcccgccatc caatggacct
    21721 tgccatcgtc agggtgtcgc gtgagggcct tctggatgcc caccttgacc tacagggcaa
    21781 ctccgtcagc accttgtcgt acgaccggtt cagcatcggc ggcgacaacc taattgcacg
    21841 ccatcatgca gtgcagaagg taaggagagg ggactcgggt cttctggaga ccttaccgga
    21901 gccggacccc accttcaggg acttgttccg ctacttccgg ttcgtcagga gtacgcgggc
    21961 gctgcaagtg accgagacgg aaatcgtaga gttgcgggac caacttcgtc gagccttggg
    22021 gtcatgaccg ccctggcaag gtgaccactt cgaccaggtc ggcgaggtct accaactggg
    22081 ccacctctca aacgctggcg cagtacgcga tgtggtactc gatgtgccgc accctcagca
    22141 gttggcgccc gttcaggcag gacggccctc gaccgtccag ccgtgcacgc caacccaccg
    22201 catagggcca atcgtagaga ccatcaagtc gacggcagct aaaacgctga cctgcttacg
    22261 gcgaggcgat gcgcctcgat tgtggctacg ctgcactggc atgaccgttc tccgttccat
    22321 tcgcctagag gctctcctcg gcggagcgtt gatcacgacg ggggcgaatt gtcggttggt
    22381 gcgtgcacaa tgcgagacgg ggtctggagg tgcaccatcg ccgagcaagt tcgtcaaaga
    22441 tcgagtactc tcatgctgtc gggaaggtcc aagttcgcca acgagttggc gacgctcgac
    22501 ccccggctca gaagcgctct aggtgtattc gatggcgcga ttcttgtcgt ggatctttgt
    22561 atcgccatcg cccgcctgct gattgacgac acagacgaac ggccatggcc tgaccgcctc
    22621 tctgacttag aggatctgat tgaagcatgg cagccacagc tagttgacgc tctcgaaggc
    22681 atggaacagc tggtcagaga ccctgacgcc gtcctccgga gagtcaagtc ccccggattc
    22741 cgggacttcg cgcaccgact tctgggagaa gcaacatttc accgactcag cagcgcgatc
    22801 aagaccgacg gtgccgtgct cgcggttggc gcacgcaggg gcattcgaaa attgatgccc
    22861 ctcgcccttg ctctcgacaa ctgcatgacc ttcgtgaccg ccgagcagtt ctcccagatc
    22921 aagggcttca cccagttcaa tgagtcgttg cttcgcatgg tcctgctgct ggatcaggcg
    22981 atggacaagg tgttcgatct agatcttcca gtagagtccg tcactgaacg cattgaagaa
    23041 ttggagccgc tggtcgaaga cacggctgca gacatcaccc gcgtcgctga ccagcttcac
    23101 ggagtgatca caggccagtc gaacgaggtt ctcctagatc tcagtggccg actgagtcgg
    23161 aaggtccgcg gagcgcgtga cgccctcgac cactccgctg acggtgtgtc gcaggctgca
    23221 aactctctcg tcgaattcat cgatcgcctg ttgcgagaag cctacgacga taggaccgtg
    23281 atcaactggg tgaacagcac ccacccggag gagggcgact tgctgtacgc ggacaaggac
    23341 tcgggccgcg ttcgcccaac taagcgagcc cagaccctct gttttgtgta cggagggcgg
    23401 gcaccgggcg acgatctgtt cgtcttcaac gagatggcgg ctgcgggtct tgtagctacg
    23461 cgagggcggt tgcagaagct caagcactcc gatgacgggt cacagaagga gactcaggat
    23521 gtccgtcgag gcatagcggc cgtggaggga tttatcgtgt acgcggtccg cgtcgggtgg
    23581 atggctatgc ccgacgaaga acttaccgcg atgcgtgtcc ggctcgggaa catccgctct
    23641 cagagtgaaa ggtagagcct ccacagccct gctgcagcgt gggtgactcc catcgcgcca
    23701 cattccaggg agatgggcgc ctgcggcgaa gtacgcgaac ccgagtggcc aggtggaact
    23761 tgcggactac gggacggatt cgcaaatctg aaggtcgccg gctgtagccc tcggccggtt
    23821 gacggtgcag tctccccagt tcaccacaac tacccgtcac actccgaaca ggggtgatgg
    23881 cccggttagg gaacttcgac ggctgcgacg atatggggct ttccattgct tgcggagacg
    23941 acggacagcc gcccataggc gtaggcccgt aggagaatcc ggaccgcatc gtcaagccct
    24001 atgccgtcct cagcggctcg ggctcgagcg gcttcccaga ccagttccga cacctggatg
    24061 tcgcccaagc tctgaacatg actcccagcg tccgacattc acactcctcc gtactgaccg
    24121 tcgtgccgca cacggtagcc ggcgcaccgt ccccgactga tacttaagag agggccgtca
    24181 gctgatccac aagccggact cctcccgcgg gagccacacc cgtcagcatt ccctaggcct
    24241 cgctcataac acaagttgca taaatatgca agtttcgggc cgtcgagatg tcatcccgac
    24301 gtaccctgag tcgttaagtg atcaacaccg cgttaagggc gcgccatcac gctgcgacga
    24361 ggttgatacc tcgtccagtt cggcgcgtct gctggcagat tcgggtacgg aggaatattg
    24421 aagatcactc cttcgtcgcg catcttgaag atgctgggcg agatcgagtt cgatgagtgg
    24481 cagtgcatcg ccgagcttgt ggacaacgct tttgatgact tcacggagat caagaagtcc
    24541 ggggtgccat gggctggcgg cttcaaggtg agcgtgagct tgccgtcaaa tggcgcgaag
    24601 tcccacgagg cgaaggtggt aatccaggac accggtcgcg ggatgagcta tgaggaactg
    24661 gagctggccg ttcgggctgg ctggtcgaat aacgaccggt tcgacaagct gggcctgttc
    24721 gggatggggt tcaacgtcag caccgcgcgc ttgggcaggc gaaccagggt gctcacgaca
    24781 cgcgccggcg accctcactg gatcggggtc gagatcgacc ttgatcgcat caaggatgat
    24841 ttcgaggccg aagacatcgt cgagcctaag gccgacccga acgagcacgg aaccaagatt
    24901 gagatctcgc ggctccacgc cgagagggcg gactggctgc gcaggaacgc ggccaatctg
    24961 cgcaccacac tcggtcgcac gtactcctac atcctggaga acaacggcta cgagctgtgg
    25021 gtgggcggac agagggtcaa gccgcggcgg cactgccgct ggggcgacga ccgatatgtg
    25081 atcttcggga gcggggcgtc ttcggagaag atcccggcat acatcg
//
