LOCUS       NZ_BMMM01000040         7365 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces albiflavescens strain CGMCC 4.7111 sequence40, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMM01000040
VERSION     NZ_BMMM01000040.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces albiflavescens
  ORGANISM  Streptomyces albiflavescens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 7365)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 100X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645835.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:24:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,828
            CDSs (total)                      :: 9,745
            Genes (coding)                    :: 9,386
            CDSs (with protein)               :: 9,386
            Genes (RNA)                       :: 83
            rRNAs                             :: 1, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 102 of 359
            Pseudo Genes (incomplete)         :: 321 of 359
            Pseudo Genes (internal stop)      :: 17 of 359
            Pseudo Genes (multiple problems)  :: 80 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:54:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 7365
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMM01000040.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..7365
                     /culture_collection="CGMCC:4.7111"
                     /db_xref="taxon:1623582"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces albiflavescens"
                     /strain="CGMCC 4.7111"
                     /submitter_seqid="sequence40"
                     /type_material="type strain of Streptomyces albiflavescens"
     region          1..7365
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..7365
                     /SMILES="NC(CC1=CNc2c1cccc2)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..7365
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<561:5888](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <562..5888
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            39..>497
                     /locus_tag="IEY95_RS48325"
     CDS             39..>497
                     /NRPS_PKS="Domain: AMP-binding (10-152). E-value: 5.5e-42.
                     Score: 135.7. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48325_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="IEY95_RS48325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_268240564.1"
                     /sec_met_domain="AMP-binding (E-value: 8.5e-46, bitscore:
                     143.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAEEGPGCFAGLREVLTGGDVVPARSVARVREACPGVVVRHLYG
                     PTETTLCATWHVLAPGDAAASVLPIGRPLSHRRIFVLDAFLQPVPPGTVGELYVSGAGL
                     AAGYWDRPALTAERFVACPFAAGERMYRTGDLVRWTDDGELLFVGRADA"
     aSDomain        69..494
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48325_AMP-binding.1"
                     /evalue="5.50E-42"
                     /label="IEY95_RS48325_AMP-binding.1"
                     /locus_tag="IEY95_RS48325"
                     /protein_end="152"
                     /protein_start="10"
                     /score="135.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AGLREVLTGGDVVPARSVARVREACPGVVVRHLYGPTETTLCATW
                     HVLAPGDAAASVLPIGRPLSHRRIFVLDAFLQPVPPGTVGELYVSGAGLAAGYWDRPAL
                     TAERFVACPFAAGERMYRTGDLVRWTDDGELLFVGRAD"
     CDS_motif       168..194
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48325_0001"
                     /evalue="1.80E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="IEY95_RS48325"
                     /protein_end="52"
                     /protein_start="43"
                     /score="10.8"
                     /tool="antismash"
                     /translation="YGPTETTLC"
     CDS_motif       306..395
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48325_0002"
                     /evalue="7.90E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="IEY95_RS48325"
                     /protein_end="119"
                     /protein_start="89"
                     /score="56.5"
                     /tool="antismash"
                     /translation="PPGTVGELYVSGAGLAAGYWDRPALTAERF"
     assembly_gap    498..559
                     /estimated_length=62
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <560..5888
                     /locus_tag="IEY95_RS48335"
     CDS             <562..5888
                     /NRPS_PKS="Domain: PCP (57-124). E-value: 1.3e-23. Score:
                     75.0. Matches aSDomain: nrpspksdomains_IEY95_RS48335_PCP.1"
                     /NRPS_PKS="Domain: Cglyc (158-454). E-value: 1.5e-136.
                     Score: 446.4. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48335_Cglyc.1"
                     /NRPS_PKS="Domain: AMP-binding (633-1036). E-value:
                     7.3e-104. Score: 339.5. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48335_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1143-1209). E-value: 1.4e-21.
                     Score: 68.5. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48335_PCP.2"
                     /NRPS_PKS="Domain: Epimerization (1223-1588). E-value:
                     3.6e-110. Score: 360.8. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48335_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1601-1761). E-value: 9.5e-40.
                     Score: 127.9. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48335_TIGR01720.1"
                     /NRPS_PKS="Domain: NRPS-COM_Cterm (1745-1764). E-value:
                     3.7e-07. Score: 21.9. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48335_NRPS-COM_Cterm.1"
                     /codon_start=2
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845108.1"
                     /locus_tag="IEY95_RS48335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_229703879.1"
                     /sec_met_domain="Condensation (E-value: 6.1e-67, bitscore:
                     213.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-112, bitscore:
                     364.0, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 8.1e-15, bitscore:
                     43.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="SSVRAYLAESLPDYMVPAAVLTLDELPLTRNGKVDRAALPAPDFA
                     DKVTGRAPRTDAEAALCELFAEVLGMERVGADDSFFELGGDSIMSMQVASRARGAGLFF
                     TAEDVFRQRTPTRLAAVAGHGEEAGPAGDRRAGSLLADLGEEDAEHLRDQVPNMVDVWP
                     LSPLQEGLLFHATFDERGPDVYASQRMLALDGPLDVDRLRASWQALLARHPVLRGSFHQ
                     RASGETVQVIASYVEPRWREADLTGLASDAVPGELARLADAERMERFDLGDAPLLRLLL
                     IRLGADRSRQVVTVHHALVDGWSTDVVFAELSEVYAAGGQASALAPVTSYTEYLAWLSR
                     QDKDAAREAWRAELDGVAEPTLVAPEGVGTQAVPEPVSFELSGELTGAVADLARSQGVT
                     VNTVVQGAWALVLARLVGRTDVVFGATVASRPAELPGVESAVGLFLNTLPVRVSLAAEQ
                     PVAGMLADLRDRQVALMARQHLGLREIHQLVGAGAEFDTLVVYENLPRTPAVREGVDPR
                     RTGSAGSLSVRTVGDPQDRGHYPMALIVMPDERLRGHLVCRPDVVDRALGESVVVSLTR
                     VLEQMAADPSAPVGRLDVLGAAERAHVAAQSVTTAREHARRVRAGEPTRSPALAPELFA
                     RQAAATPTAVALVDGARTLTYGELVAESAGLARRLVRAGVAPETRVAVVADRSAELVMA
                     LLAVSTAGGVYVPVDPGLPEARMRLVLGDVAPPVLVCTRAARDAVPPDFNGRLVVVDDP
                     AAAEVEATRAEGPVTDHEHTRPLTADHAAYVIYTSGSTGTPKGAVVPHGSLRNLVADRV
                     ERYRIGADSAVLQLVPPSFDVSMADIWPVLCAGGRLVLGPPTKHHASGEDLVRLMRAER
                     VTHVAMTPTVLAQLPPEELPLLRVLIVGGEPLPDDLRGQWTAGREVYSEYGVTEATVAS
                     TVSRPLGHPLGAPGTPPIGRPITGTEAYVLDAFLHPVPPGVVGELYLSGAGLARGYLSR
                     PGLTAQRFVACPFAAGQRMYRTGDLARRTDDGELRYAGRADAQVKVRGFRVEPGEIEAA
                     LAAHPEVGRAVVVLRQDRQGERRLVGYVVPRGSGGVDPELVRAYAAKELPGHMVPAAVV
                     ALDALPATHNGKVDVTALPAPDFAELSSGRAPQGAAEEILCAMFAEVLGLEHVGADANF
                     FALGGDSITSMQLVSRARRAGAFFGAQDVFEHRSPAALARVVRLGDRTPYGADGGADEG
                     EVVWTPVMRALGERAAMGPGFTQWVVIGTPPSLDADTLTAGLRALLDAHAMLRARTEAD
                     GPEPRLVVGRPGSVDAADLITRIDATGESAQDLEELADRAAREAVLRLEPRSGVMLQAA
                     WVDAGAGRVGRLALVVHHLAVDGVSWRILVPDLRAACEAVAAGRQPRLDPVGTSFRRWS
                     RLLAQEAAARHRVAELDAWTRVLDTREPPLGARELDPERDVAAAERHRSWVVPPQQTAT
                     LTARTPALFHCGVHEVLLATLAGAVVHGRSGVDAGGVEGRRPGVGDAVVDGRSGTADLG
                     VRQRSVSEGMAIHGRPVPDGAGTRQRTVSDGTILLDVEGHGRKPVGDADLLRTVGWFTS
                     VHPIRLDLAAIDVTRALEGGPAAGTLLKAVKEQARAVPGDGLGYGLLRHLNPETGPALA
                     ALPGPQIGFNYLGRFPAGSREGALAPWQMAGQDAIGGSADPAMPTLHALEASAAVRDTL
                     DGPELTITLTWHPAVLDDAAADRLGRLWLDLLAGLAAHTTHPAAGGHTPSDFPLIELAQ
                     DEVEQFEAIAAELEGGRTW"
     aSDomain        735..935
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48335_PCP.1"
                     /evalue="1.30E-23"
                     /label="IEY95_RS48335_PCP.1"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="124"
                     /protein_start="57"
                     /score="75.0"
                     /tool="antismash"
                     /translation="EAALCELFAEVLGMERVGADDSFFELGGDSIMSMQVASRARGAGL
                     FFTAEDVFRQRTPTRLAAVAGH"
     CDS_motif       738..773
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0001"
                     /evalue="2.40E+00"
                     /label="Cy4"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="70"
                     /protein_start="58"
                     /score="1.6"
                     /tool="antismash"
                     /translation="AALCELFAEVLG"
     CDS_motif       798..827
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0002"
                     /evalue="9.30E-02"
                     /label="PCP_mE"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="88"
                     /protein_start="78"
                     /score="6.0"
                     /tool="antismash"
                     /translation="SFFELGGDSI"
     aSDomain        1038..1925
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48335_Cglyc.1"
                     /domain_subtypes="Cglyc"
                     /evalue="1.50E-136"
                     /label="IEY95_RS48335_Cglyc.1"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="454"
                     /protein_start="158"
                     /score="446.4"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHALVDG"
                     /tool="antismash"
                     /translation="VDVWPLSPLQEGLLFHATFDERGPDVYASQRMLALDGPLDVDRLR
                     ASWQALLARHPVLRGSFHQRASGETVQVIASYVEPRWREADLTGLASDAVPGELARLAD
                     AERMERFDLGDAPLLRLLLIRLGADRSRQVVTVHHALVDGWSTDVVFAELSEVYAAGGQ
                     ASALAPVTSYTEYLAWLSRQDKDAAREAWRAELDGVAEPTLVAPEGVGTQAVPEPVSFE
                     LSGELTGAVADLARSQGVTVNTVVQGAWALVLARLVGRTDVVFGATVASRPAELPGVES
                     AVGLFLNTLPVRVSL"
     aSModule        1038..5846
                     /complete
                     /domains="nrpspksdomains_IEY95_RS48335_Cglyc.1"
                     /domains="nrpspksdomains_IEY95_RS48335_AMP-binding.1"
                     /domains="nrpspksdomains_IEY95_RS48335_PCP.2"
                     /domains="nrpspksdomains_IEY95_RS48335_Epimerization.1"
                     /domains="nrpspksdomains_IEY95_RS48335_TIGR01720.1"
                     /locus_tags="IEY95_RS48335"
                     /monomer_pairings="Trp -> D-Trp"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1047..1088
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0003"
                     /evalue="1.30E-04"
                     /label="C1_DCL_004-017"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="175"
                     /protein_start="161"
                     /score="14.0"
                     /tool="antismash"
                     /translation="WPLSPLQEGLLFHA"
     CDS_motif       1110..1229
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0004"
                     /evalue="1.10E-15"
                     /label="C2_DCL_024-062"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="222"
                     /protein_start="182"
                     /score="49.9"
                     /tool="antismash"
                     /translation="DVYASQRMLALDGPLDVDRLRASWQALLARHPVLRGSFHQ"
     CDS_motif       1446..1511
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0005"
                     /evalue="5.00E-08"
                     /label="C3_DCL_135-156"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="316"
                     /protein_start="294"
                     /score="25.5"
                     /tool="antismash"
                     /translation="VHHALVDGWSTDVVFAELSEVY"
     CDS_motif       1752..1805
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0006"
                     /evalue="1.70E-01"
                     /label="Cy4"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="414"
                     /protein_start="396"
                     /score="5.2"
                     /tool="antismash"
                     /translation="GVTVNTVVQGAWALVLAR"
     CDS_motif       1821..1916
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0007"
                     /evalue="7.60E-19"
                     /label="C5_DCL_263-294"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="451"
                     /protein_start="419"
                     /score="60.1"
                     /tool="antismash"
                     /translation="DVVFGATVASRPAELPGVESAVGLFLNTLPVR"
     CDS_motif       1968..2078
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0008"
                     /evalue="4.20E-11"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="505"
                     /protein_start="468"
                     /score="35.2"
                     /tool="antismash"
                     /translation="DRQVALMARQHLGLREIHQLVGAGAEFDTLVVYENLP"
     aSDomain        2463..3671
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48335_AMP-binding.1"
                     /evalue="7.30E-104"
                     /label="IEY95_RS48335_AMP-binding.1"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1036"
                     /protein_start="633"
                     /score="339.5"
                     /specificity="substrate consensus: Trp"
                     /tool="antismash"
                     /translation="FARQAAATPTAVALVDGARTLTYGELVAESAGLARRLVRAGVAPE
                     TRVAVVADRSAELVMALLAVSTAGGVYVPVDPGLPEARMRLVLGDVAPPVLVCTRAARD
                     AVPPDFNGRLVVVDDPAAAEVEATRAEGPVTDHEHTRPLTADHAAYVIYTSGSTGTPKG
                     AVVPHGSLRNLVADRVERYRIGADSAVLQLVPPSFDVSMADIWPVLCAGGRLVLGPPTK
                     HHASGEDLVRLMRAERVTHVAMTPTVLAQLPPEELPLLRVLIVGGEPLPDDLRGQWTAG
                     REVYSEYGVTEATVASTVSRPLGHPLGAPGTPPIGRPITGTEAYVLDAFLHPVPPGVVG
                     ELYLSGAGLARGYLSRPGLTAQRFVACPFAAGQRMYRTGDLARRTDDGELRYAGRADAQ
                     VKVR"
     CDS_motif       2907..2966
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0009"
                     /evalue="1.30E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="801"
                     /protein_start="781"
                     /score="30.0"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGTPKGAVVPH"
     CDS_motif       3465..3554
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0010"
                     /evalue="4.90E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="997"
                     /protein_start="967"
                     /score="54.0"
                     /tool="antismash"
                     /translation="PPGVVGELYLSGAGLARGYLSRPGLTAQRF"
     CDS_motif       3636..3701
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0011"
                     /evalue="2.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1046"
                     /protein_start="1024"
                     /score="35.5"
                     /tool="antismash"
                     /translation="YAGRADAQVKVRGFRVEPGEIE"
     CDS_motif       3747..3794
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0012"
                     /evalue="3.70E+00"
                     /label="C5_LCL_267-296"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1077"
                     /protein_start="1061"
                     /score="0.2"
                     /tool="antismash"
                     /translation="LRQDRQGERRLVGYVV"
     aSDomain        3993..4190
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48335_PCP.2"
                     /evalue="1.40E-21"
                     /label="IEY95_RS48335_PCP.2"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1209"
                     /protein_start="1143"
                     /score="68.5"
                     /tool="antismash"
                     /translation="EEILCAMFAEVLGLEHVGADANFFALGGDSITSMQLVSRARRAGA
                     FFGAQDVFEHRSPAALARVVR"
     CDS_motif       3999..4031
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0013"
                     /evalue="1.40E-01"
                     /label="Cy4"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1156"
                     /protein_start="1145"
                     /score="5.5"
                     /tool="antismash"
                     /translation="ILCAMFAEVLG"
     CDS_motif       4056..4085
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0014"
                     /evalue="1.70E-01"
                     /label="PCP_mE"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1174"
                     /protein_start="1164"
                     /score="5.4"
                     /tool="antismash"
                     /translation="NFFALGGDSI"
     aSDomain        4233..5327
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48335_Epimerization.1"
                     /evalue="3.60E-110"
                     /label="IEY95_RS48335_Epimerization.1"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1588"
                     /protein_start="1223"
                     /score="360.8"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLAVDG"
                     /tool="antismash"
                     /translation="EGEVVWTPVMRALGERAAMGPGFTQWVVIGTPPSLDADTLTAGLR
                     ALLDAHAMLRARTEADGPEPRLVVGRPGSVDAADLITRIDATGESAQDLEELADRAARE
                     AVLRLEPRSGVMLQAAWVDAGAGRVGRLALVVHHLAVDGVSWRILVPDLRAACEAVAAG
                     RQPRLDPVGTSFRRWSRLLAQEAAARHRVAELDAWTRVLDTREPPLGARELDPERDVAA
                     AERHRSWVVPPQQTATLTARTPALFHCGVHEVLLATLAGAVVHGRSGVDAGGVEGRRPG
                     VGDAVVDGRSGTADLGVRQRSVSEGMAIHGRPVPDGAGTRQRTVSDGTILLDVEGHGRK
                     PVGDADLLRTVGWFTSVHPIRLDLA"
     CDS_motif       4332..4403
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0015"
                     /evalue="7.00E-05"
                     /label="C2_DCL_024-062"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1280"
                     /protein_start="1256"
                     /score="15.1"
                     /tool="antismash"
                     /translation="SLDADTLTAGLRALLDAHAMLRAR"
     CDS_motif       4626..4691
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0016"
                     /evalue="4.10E-11"
                     /label="NRPS-E2"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1376"
                     /protein_start="1354"
                     /score="35.0"
                     /tool="antismash"
                     /translation="LALVVHHLAVDGVSWRILVPDL"
     CDS_motif       5268..5318
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0017"
                     /evalue="3.80E-07"
                     /label="NRPS-E5"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1585"
                     /protein_start="1568"
                     /score="22.3"
                     /tool="antismash"
                     /translation="DLLRTVGWFTSVHPIRL"
     aSDomain        5367..5846
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48335_TIGR01720.1"
                     /evalue="9.50E-40"
                     /label="IEY95_RS48335_TIGR01720.1"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1761"
                     /protein_start="1601"
                     /score="127.9"
                     /tool="antismash"
                     /translation="AGTLLKAVKEQARAVPGDGLGYGLLRHLNPETGPALAALPGPQIG
                     FNYLGRFPAGSREGALAPWQMAGQDAIGGSADPAMPTLHALEASAAVRDTLDGPELTIT
                     LTWHPAVLDDAAADRLGRLWLDLLAGLAAHTTHPAAGGHTPSDFPLIELAQDEVEQ"
     CDS_motif       5388..5450
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48335_0018"
                     /evalue="9.90E-10"
                     /label="NRPS-E6"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1629"
                     /protein_start="1608"
                     /score="30.6"
                     /tool="antismash"
                     /translation="VKEQARAVPGDGLGYGLLRHL"
     aSDomain        5799..5855
                     /aSDomain="NRPS-COM_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48335_NRPS-COM_Cterm.1"
                     /evalue="3.70E-07"
                     /label="IEY95_RS48335_NRPS-COM_Cterm.1"
                     /locus_tag="IEY95_RS48335"
                     /protein_end="1764"
                     /protein_start="1745"
                     /score="21.9"
                     /tool="antismash"
                     /translation="PSDFPLIELAQDEVEQFEA"
     gene            5882..>7365
                     /locus_tag="IEY95_RS48345"
     CDS             5882..>7365
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (23-43). E-value:
                     7.4e-09. Score: 26.7. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48345_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Cglyc (25-324). E-value: 4.5e-142.
                     Score: 464.5. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48345_Cglyc.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018844992.1"
                     /locus_tag="IEY95_RS48345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_268240565.1"
                     /sec_met_domain="Condensation (E-value: 2.8e-70, bitscore:
                     224.4, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTSSTPAEAAARAEGSSTAAKGSALAEVWPLSPLQEGLLFHADF
                     DGRGPDVYTVQNVLAVDGPLVPARFRASWEALLTRHAALRASFQRRKTGEAVQMITREV
                     VLPWSEADVSDLAEEEASAQAERLAAGERAHCIDPAKPPLLRLLLIRLGERRHRLVMTS
                     HHILMDGWSAPILLKELAQVYAAGGDASGLAPVTSYREYLAWLARQDKDAARAAWQAEL
                     ADVAEPTRVGATAPSEHAEEPKRVSAHLSEATTTALTELARAQGLTVNTVVQGAWALVL
                     ARLAGRTDVVFGATVAGRPPELPGADSMIGLLINTLPVRVRLDGSQPVLEMLRELQNRQ
                     SALMAHQHIGLPELQQLVGPGAAFDTLLVYENYPLPPGQALAPDALSVTTVTSRQATHY
                     PLSLGIFPGERLRVGVTYRPDQIDAAVGETLGGLLVRVLEGVVADPSVVVGRVGLVEGA
                     ERVRVGEVRGGVPVPVSVPELIRGRVVSAPDAVAVVG"
     aSDomain        5951..6010
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48345_NRPS-COM_Nterm.1"
                     /evalue="7.40E-09"
                     /label="IEY95_RS48345_NRPS-COM_Nterm.1"
                     /locus_tag="IEY95_RS48345"
                     /protein_end="43"
                     /protein_start="23"
                     /score="26.7"
                     /tool="antismash"
                     /translation="SALAEVWPLSPLQEGLLFHA"
     aSDomain        5957..6853
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48345_Cglyc.1"
                     /domain_subtypes="Cglyc"
                     /evalue="4.50E-142"
                     /label="IEY95_RS48345_Cglyc.1"
                     /locus_tag="IEY95_RS48345"
                     /protein_end="324"
                     /protein_start="25"
                     /score="464.5"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHILMDG"
                     /tool="antismash"
                     /translation="LAEVWPLSPLQEGLLFHADFDGRGPDVYTVQNVLAVDGPLVPARF
                     RASWEALLTRHAALRASFQRRKTGEAVQMITREVVLPWSEADVSDLAEEEASAQAERLA
                     AGERAHCIDPAKPPLLRLLLIRLGERRHRLVMTSHHILMDGWSAPILLKELAQVYAAGG
                     DASGLAPVTSYREYLAWLARQDKDAARAAWQAELADVAEPTRVGATAPSEHAEEPKRVS
                     AHLSEATTTALTELARAQGLTVNTVVQGAWALVLARLAGRTDVVFGATVAGRPPELPGA
                     DSMIGLLINTLPVRVRLD"
     CDS_motif       5969..6010
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48345_0001"
                     /evalue="2.70E-05"
                     /label="C1_DCL_004-017"
                     /locus_tag="IEY95_RS48345"
                     /protein_end="43"
                     /protein_start="29"
                     /score="15.9"
                     /tool="antismash"
                     /translation="WPLSPLQEGLLFHA"
     CDS_motif       6032..6148
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48345_0002"
                     /evalue="6.10E-16"
                     /label="C2_DCL_024-062"
                     /locus_tag="IEY95_RS48345"
                     /protein_end="89"
                     /protein_start="50"
                     /score="50.7"
                     /tool="antismash"
                     /translation="DVYTVQNVLAVDGPLVPARFRASWEALLTRHAALRASFQ"
     CDS_motif       6371..6433
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48345_0003"
                     /evalue="5.20E-13"
                     /label="C3_DCL_135-156"
                     /locus_tag="IEY95_RS48345"
                     /protein_end="184"
                     /protein_start="163"
                     /score="41.3"
                     /tool="antismash"
                     /translation="HHILMDGWSAPILLKELAQVY"
     CDS_motif       6476..6511
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48345_0004"
                     /evalue="2.00E-03"
                     /label="C4_DCL_171-183"
                     /locus_tag="IEY95_RS48345"
                     /protein_end="210"
                     /protein_start="198"
                     /score="10.8"
                     /tool="antismash"
                     /translation="YREYLAWLARQD"
     CDS_motif       6746..6841
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48345_0005"
                     /evalue="2.20E-20"
                     /label="C5_DCL_263-294"
                     /locus_tag="IEY95_RS48345"
                     /protein_end="320"
                     /protein_start="288"
                     /score="65.0"
                     /tool="antismash"
                     /translation="DVVFGATVAGRPPELPGADSMIGLLINTLPVR"
     CDS_motif       6890..7003
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48345_0006"
                     /evalue="1.70E-15"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="IEY95_RS48345"
                     /protein_end="374"
                     /protein_start="336"
                     /score="49.3"
                     /tool="antismash"
                     /translation="QNRQSALMAHQHIGLPELQQLVGPGAAFDTLLVYENYP"
     CDS_motif       7031..7078
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48345_0007"
                     /evalue="1.60E+00"
                     /label="C3_starter_134-155"
                     /locus_tag="IEY95_RS48345"
                     /protein_end="399"
                     /protein_start="383"
                     /score="2.0"
                     /tool="antismash"
                     /translation="DALSVTTVTSRQATHY"
ORIGIN
        1 ggggcactgc ggtgcacttg acggcggggt ctttccgggt gttggcggag gaggggccgg
       61 ggtgtttcgc ggggttgcgt gaggtgttga cgggtgggga tgtggttcct gcgcggtcgg
      121 tggcgcgggt gcgggaggcg tgcccgggtg tggtcgtgcg gcacttgtat gggccgacgg
      181 agacgacgtt gtgtgcgacc tggcatgtcc tggcccctgg tgatgcggcg gcttcggtgc
      241 tgcctatcgg gcgcccgctg tctcaccgca ggatctttgt gctggacgcg ttcttgcagc
      301 cggtcccgcc tggcacggtg ggtgaactgt atgtgtccgg tgccgggctg gctgccggtt
      361 actgggaccg tccggcgctg accgccgaac gcttcgtcgc gtgcccgttc gctgcggggg
      421 agcggatgta tcgcaccggg gatctggtgc gctggacgga cgacggtgag ttgctgttcg
      481 tcggccgcgc ggacgcgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      541 nnnnnnnnnn nnnnnnnnnc tcgtcggtcc gtgcgtatct cgccgagtcg cttccggact
      601 acatggtgcc cgccgccgtc ctcactctcg acgagctgcc gctcacccgt aacggcaagg
      661 tcgaccgggc tgctctgccc gcccctgact ttgccgacaa ggtgaccggg cgggcgccgc
      721 gcaccgacgc cgaggccgcg ctctgtgagc tgttcgccga ggtgctcggg atggagcgcg
      781 taggtgcgga tgacagtttc ttcgagctcg gcggcgactc gatcatgtcg atgcaggtgg
      841 cgtcccgggc gcgtggggcg ggcctgttct tcacagcgga ggacgtgttc cggcagagga
      901 caccgacgcg cctcgccgcg gtggccgggc acggcgagga agcggggccg gccggtgacc
      961 gtcgcgccgg gtcactcctg gcggatctgg gtgaggagga cgcggagcat ctgcgggacc
     1021 aggtgccgaa catggtggac gtctggccac tgtcacccct ccaggagggg ttgcttttcc
     1081 acgccacgtt cgacgagcgg ggtcccgacg tgtacgcgag ccagcggatg ctggcgctcg
     1141 acggtccgct ggacgtggac cggttgcggg cgtcgtggca ggcgctcctc gcccggcacc
     1201 cggtactgcg cgggagcttc caccagcgcg cgtccggtga gacggtgcag gtcatcgcgt
     1261 cctacgtgga gccgcgctgg cgcgaggccg atctcacggg gcttgcgtcg gacgccgtac
     1321 ccggcgagct ggcgcggctg gccgatgccg agcggatgga gcggttcgat ctcggggacg
     1381 ccccgctgtt acggctgctg ctgatacgtc tgggcgcgga ccgctcccgc caggtcgtca
     1441 ccgtccatca cgctctggtg gacggctggt ccacggatgt cgtcttcgcg gagttgtccg
     1501 aggtgtacgc ggccggtggc caggcctcgg cgctcgcacc cgtcacgtcg tacacggagt
     1561 acctggcgtg gctgtcccgg caggacaagg acgcggcgcg cgaggcgtgg cgggccgaac
     1621 tcgacggcgt ggcggagccc acgctggtgg cgcccgaagg agtcgggacg caagcggttc
     1681 cggagccggt gtcgttcgag ctgtccggtg aactcacggg cgcggtggcg gacttggcgc
     1741 gctcgcaagg cgtgaccgtg aacaccgtgg tgcagggtgc ctgggcactg gttctcgccc
     1801 ggctcgtggg gcgcacggac gtggtgttcg gcgccacggt ggcgagccgg ccggcggagc
     1861 ttcccggggt cgagtcggcg gtcggtctgt tcctcaacac gctcccggta cgcgtgagtc
     1921 tggcagcgga gcagccggtc gccgggatgc tggcggacct gcgggaccgg caggtcgcgc
     1981 tgatggcccg gcagcatctg gggctccgcg agatccacca actcgtcggg gcgggcgcag
     2041 agttcgacac gctcgtggtg tacgagaacc ttcctcgtac gcccgcggtc agggagggcg
     2101 tcgaccctcg gaggaccgga tccgccggct ccctgagcgt acgtactgtc ggcgacccgc
     2161 aggaccgggg tcactatccg atggcgctga tcgtgatgcc cgacgagcgg ctgcgcggcc
     2221 atctcgtctg ccggccggac gtggtcgacc gggccctggg ggagtcggtg gtggtatcgc
     2281 tgacccgggt cctcgaacag atggcggcgg atccgtcggc gccggtggga cgccttgacg
     2341 tgctcggcgc ggcggaacgc gcacatgtcg cggcacagtc cgtcaccacc gcacgggaac
     2401 acgcgcgtcg ggtgcgcgcc ggggagccga cgcggtcgcc tgctctggcg ccggagctgt
     2461 tcgcccgaca ggccgccgcc acacccaccg cggtggcgtt ggtggacggc gcccgtacgc
     2521 tgacgtacgg cgaactggtc gctgaatcgg ccggactggc tcgccggctc gtgcgggcgg
     2581 gcgtggcccc ggagacccgg gtggccgtcg tcgccgaccg gtcggcggag ctggtgatgg
     2641 ctctcctcgc ggtgtcgacg gccggcgggg tgtacgtccc cgtcgacccg gggcttcccg
     2701 aggcgcggat gcgtctggtc ctcggcgatg tcgcacctcc ggtcctggtg tgcacgcgtg
     2761 cggcccgcga cgccgtacca ccggacttca acggtcgcct cgtggtcgtg gacgaccccg
     2821 cggcggccga ggtggaggcc acccgcgccg aaggccccgt gacggaccat gagcacacac
     2881 ggccgctgac cgcggaccac gcggcgtacg tcatctacac ctcgggttcc acgggcaccc
     2941 ccaagggtgc cgtcgtcccg cacgggagcc tgcgcaacct ggtcgccgac cgtgtggagc
     3001 gataccggat cggcgccgac agcgccgtgc tgcaactggt cccgccgagc ttcgacgtgt
     3061 cgatggcgga catctggccg gtgctgtgcg cgggcggccg actggtcctc gggccgccga
     3121 cgaaacacca cgcgagcggc gaggacctgg tccggctgat gcgcgccgag cgcgtcaccc
     3181 atgtcgcgat gaccccgacc gtcctcgccc aactccctcc ggaggaactt ccgttgctgc
     3241 gggtgctcat cgtcgggggt gaacccctgc cggacgatct gcgcgggcag tggacagcgg
     3301 gccgcgaggt gtacagcgag tacggggtga ccgaggcgac ggtcgcttcc acagtgagcc
     3361 gcccactcgg gcaccccctc ggcgcccccg ggacaccgcc gatcggccgc cccatcaccg
     3421 gcaccgaggc gtacgtactg gacgccttcc tgcacccggt gcccccgggc gtagtcggtg
     3481 agctgtacct gtccggcgcg ggcctggcgc gcggctatct gagccggccg ggcctgacgg
     3541 cacagcgctt cgtggcctgt ccgttcgccg ccgggcagcg gatgtaccgc acgggcgacc
     3601 tggcacgccg gacggacgac ggcgaactcc gctacgcggg acgggccgac gcccaggtga
     3661 aggtgcgcgg gttccgggtg gagccgggag agatcgaggc ggcgctcgcc gcgcaccccg
     3721 aggtgggccg cgccgtcgtc gtcctcaggc aggaccgcca gggcgaacga cgcctcgtcg
     3781 gctacgtggt gccgcgcggc tcaggcggcg tcgaccccga gctcgtacgg gcgtacgcgg
     3841 cgaaggaact gccgggccac atggtccccg cggccgtcgt cgccctcgat gcactgccgg
     3901 ccacccacaa cgggaaggtc gacgtcacgg ccctgcccgc acccgacttc gccgaactga
     3961 gctccggcag ggcgccccag ggtgcggccg aggagatcct ctgcgcgatg ttcgccgaag
     4021 tcctcgggct ggagcacgtc ggcgccgacg ccaacttctt cgcgctgggc ggcgactcga
     4081 tcacctcgat gcaactggtg agccgggcgc gccgggccgg ggcgttcttc ggtgcccagg
     4141 acgtgttcga gcacaggtca cccgccgccc tcgcccgggt cgtccgactc ggtgacagga
     4201 cgccgtacgg agcggacggc ggcgcggacg agggcgaggt cgtctggacg cccgtgatgc
     4261 gggccctggg ggagcgggca gccatgggcc ccggattcac ccagtgggtc gtgatcggaa
     4321 caccgccgag tcttgacgcc gacaccttga cggcgggcct gcgggcgctg ctggacgcac
     4381 acgccatgct gcgggcccgt accgaggcgg acgggcccga gccccggctc gtcgtgggcc
     4441 gccccggctc ggtcgacgct gccgacctga tcacccgcat cgacgcgacg ggcgagagcg
     4501 cccaggacct ggaggagctg gcggaccgcg ccgcacggga agcggtcctg cgcctcgaac
     4561 cgaggtccgg ggtgatgctc caggcggcat gggtggacgc gggcgccgga cgcgtgggcc
     4621 gactggccct cgtcgtacac cacttggcgg tcgacggcgt ctcctggcgg atcctcgtac
     4681 cggacctgcg ggccgcctgc gaagcggtcg cggccggacg acagcctcga ctcgacccag
     4741 tgggcacgtc cttccggcgg tggtcgcggt tgctcgccca ggaggcggcc gcgaggcacc
     4801 gggtcgcgga actggacgcc tggacccgcg tgctcgacac ccgtgagcct ccgctcgggg
     4861 cacgggagtt ggatccggag cgcgacgtcg cggcggccga acgacaccgc tcgtgggtcg
     4921 tgcccccgca gcagaccgcc accctgacgg cccgcacccc ggcgctgttc cactgcggcg
     4981 tgcacgaggt actgctcgcc acgctcgccg gtgcggtcgt acatgggcgg tccggcgtcg
     5041 acgctggggg tgtggagggg cggcggcccg gcgtcggcga tgcggtcgtg gacggacggt
     5101 ccggcaccgc cgacctgggc gtgcgccagc ggtctgtctc tgagggaatg gccatccacg
     5161 gtcgccctgt ccctgacgga gcgggtacgc gccaacggac cgtctccgac ggaacgatcc
     5221 ttctcgatgt cgaggggcac gggcgcaagc cggtcggcga tgcggatctg ctgcgcacgg
     5281 tgggctggtt caccagcgtg cacccgatcc gcctcgatct ggccgccatc gacgtgaccc
     5341 gagccctgga gggcggaccc gccgcgggaa cgctgctgaa ggctgtcaag gagcaggcac
     5401 gcgcagtgcc cggcgacggt ctcggctacg ggctgctgcg tcacctcaac ccggagacgg
     5461 gcccggcgct cgccgcactg ccgggtccgc agatcggctt caactacctg ggccgcttcc
     5521 ccgcgggaag ccgcgagggt gccctcgcac cgtggcagat ggccggtcag gacgcgatcg
     5581 gcggctccgc cgacccggcc atgcccaccc tgcacgctct cgaagcgagc gcggccgtac
     5641 gggacaccct cgacggcccg gaactgacca tcacgctcac ctggcacccc gcggtcctcg
     5701 acgacgcggc cgcggaccga ctcggccgcc tctggctcga tctgctcgcg ggcctggccg
     5761 cacacaccac gcaccccgcg gcgggcgggc acaccccgtc cgacttcccg ctcatcgagc
     5821 tcgcccagga cgaggtcgag cagttcgaag cgatagcagc agagctcgaa ggaggacgga
     5881 catggtgacg tcgtcaaccc ccgccgaagc agcagcccgc gccgaggggt cctcgacggc
     5941 cgcgaagggc tcggcactcg cggaggtctg gcccctctcg ccgctccagg aagggctgct
     6001 gttccacgcg gacttcgacg gccgcggacc cgatgtctac accgtgcaga acgtcctggc
     6061 cgtggacggc cccctggtgc cggcacggtt ccgcgcctcc tgggaggcgc tcctgacccg
     6121 gcacgccgcg ctgcgcgcga gcttccagcg gcgcaagacg ggtgaggccg tccagatgat
     6181 cacccgcgag gtcgtcctgc cctggagcga ggcggacgtc tcggacctgg cggaggagga
     6241 agcgtcggcg caggcggagc gactggccgc cggcgaacgc gcgcactgca tcgacccggc
     6301 gaagcccccg ctgctgcggc ttctcctgat tcggctcggc gagcggcgcc accgcctggt
     6361 gatgacgagc caccacatcc tcatggacgg ctggtcggcc cccatcctcc tcaaggaact
     6421 cgcccaggtc tacgcggccg gaggggacgc gtccggcctc gcacccgtga cgtcctaccg
     6481 ggagtacctg gcgtggctgg cccggcagga caaggacgcc gcccgagccg cctggcaggc
     6541 ggagctggcc gacgtggcgg agccgacgcg ggtgggggcg acagcgccgt cggagcatgc
     6601 ggaagagccg aaaagggttt ccgcgcatct ctccgaggcg acgaccacgg ccctcaccga
     6661 gctggcccgc gcccagggtc tgacggtgaa cacggtggtg cagggtgcct gggcgctggt
     6721 cctggcgcgc ctcgccgggc ggacggacgt ggtgttcggc gcgacggtgg cgggccgccc
     6781 cccggaactc ccgggcgccg actccatgat cggtctgctc atcaacaccc tgcccgtacg
     6841 cgtacggctc gacggctcgc agccggtgct ggagatgctc cgcgagttgc agaaccgcca
     6901 gtccgcgctg atggcccacc agcacatcgg gctgccggaa ctccagcaac tcgtcggccc
     6961 cggcgcggcc ttcgacaccc ttctcgtgta cgagaactac ccgctgccgc ccggccaggc
     7021 gctcgccccc gacgcgctct ccgtgaccac cgtgacgtca cgccaggcca cgcactaccc
     7081 gctctcactg ggaatcttcc ccggcgaacg cctccgggtg ggcgtgacct accgacccga
     7141 ccagatcgac gcagcggtgg gagaaacgct gggcggactg ctcgtgcggg tgttggaggg
     7201 ggtggtggct gatccgtccg tggtggtggg acgggtcggg ttggtggagg gcgcggagcg
     7261 tgtacgggtg ggcgaggtgc gcggtggggt gccagtaccg gtgtcggtgc cggagttgat
     7321 ccgtgggcgg gtggtttcgg cgccggatgc ggtggcggtg gtggg
//
