LOCUS       NZ_BMMM01000038         8517 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces albiflavescens strain CGMCC 4.7111 sequence38, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMM01000038
VERSION     NZ_BMMM01000038.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces albiflavescens
  ORGANISM  Streptomyces albiflavescens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 8517)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 100X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645835.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:24:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,828
            CDSs (total)                      :: 9,745
            Genes (coding)                    :: 9,386
            CDSs (with protein)               :: 9,386
            Genes (RNA)                       :: 83
            rRNAs                             :: 1, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 102 of 359
            Pseudo Genes (incomplete)         :: 321 of 359
            Pseudo Genes (internal stop)      :: 17 of 359
            Pseudo Genes (multiple problems)  :: 80 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:54:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 8517
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMM01000038.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..8517
                     /culture_collection="CGMCC:4.7111"
                     /db_xref="taxon:1623582"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces albiflavescens"
                     /strain="CGMCC 4.7111"
                     /submitter_seqid="sequence38"
                     /type_material="type strain of Streptomyces albiflavescens"
     region          1..8517
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..8517
                     /SMILES="NC(Cc1ccc(O)cc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..8517
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[34:6952](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      35..6952
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            35..6952
                     /locus_tag="IEY95_RS48275"
     CDS             35..6952
                     /NRPS_PKS="Domain: PCP (186-252). E-value: 8.5e-25. Score:
                     78.8. Matches aSDomain: nrpspksdomains_IEY95_RS48275_PCP.1"
                     /NRPS_PKS="Domain: Epimerization (271-583). E-value:
                     1.3e-125. Score: 411.9. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48275_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (598-759). E-value: 6.8e-38.
                     Score: 121.9. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48275_TIGR01720.1"
                     /NRPS_PKS="Domain: Cglyc (765-1062). E-value: 2.2e-141.
                     Score: 462.3. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48275_Cglyc.1"
                     /NRPS_PKS="Domain: AMP-binding (1224-1620). E-value:
                     9e-103. Score: 335.9. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48275_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1728-1794). E-value: 2.6e-20.
                     Score: 64.4. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48275_PCP.2"
                     /NRPS_PKS="Domain: Epimerization (1808-2121). E-value:
                     2.4e-126. Score: 414.3. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48275_Epimerization.2"
                     /NRPS_PKS="Domain: TIGR01720 (2134-2296). E-value: 3.5e-39.
                     Score: 126.1. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48275_TIGR01720.2"
                     /NRPS_PKS="Domain: NRPS-COM_Cterm (2279-2298). E-value:
                     2.8e-07. Score: 22.2. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48275_NRPS-COM_Cterm.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IEY95_RS48275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_229703875.1"
                     /sec_met_domain="PP-binding (E-value: 3.5e-16, bitscore:
                     46.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.9e-68, bitscore:
                     217.8, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 8.4e-117, bitscore:
                     377.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDAFLQPVPPGTVGELYVSGAGLAAGYWDRPALTAERFVACPFA
                     AGERMYRTGDLVRWTDDGELLFVGRADAQVKVRGFRVELGEVEAVLSAHPAVSQAVVVA
                     REDVPGERRLVGYVVPEDPQAGVHAEHAREEAARQLPDYMVPAAVLVLDKLPLTRNGKV
                     DRAALPAPDFAGKVTERAPRTDAEAALCELFAEVLGLERVGVEDSFFELGGDSIMSMQL
                     VARARRAGLLLAAQDVFASPSPAELAAVAKPLDETTGTGGPSGPLSEPDVGEVPWTPAM
                     RALGERGRRGRFAQWIVVGSPAGLDRDVLVAGVAAVLDTHDMLRAGVVEADGAEPGLAV
                     RRRGSVPAAPLVSRVDAGDAPAESLDAVADQAAREATERLDPPAGVLLQIIWVDAGPER
                     TGRLVVVVHHLVIDGLSWRILIPDLQAACEAAAAGREPELPPAGTSFKRWADLLVEEAH
                     AASRIAELQDWTAQLGQPEPPLGTRELDHSLDTASTMGRRSWTLPAQHAVTLAGRTPAL
                     FHCGVHEVLLSTLAGAVTRWRRENGQGGVPGVLVDIEGHGRAPAADAELSRTLGWFSST
                     HPLRLDTVGIDLDDVLAGGPAAGVLLKAVKEQARAVPGDSLGYGLLRHLNPETGPVLAA
                     LPSPQIGFNYLGRFASHGDRHLPPAPWEMSGDAAIGGSVDPDMPAQHTLEAGAAVLDTP
                     AGPELTLTLMWPTGLLDEAEAERLGRHWLDLLAGLAAHTADPGAGGRSPSDFPLLGLGQ
                     REIDELESLVPELADIWPLSPLQEGLLFHAEYDDLGPDLYEGQRVLALDGPLDTERLRA
                     SWEALLARHPILRASFHQRASGEAVQIIARDVQLPWTQADLTGTTEADLAAALDRLFAG
                     ERARRLDVTSAPLLRLLLVRLAADRHLLALTSHHIVADGWSLPVIITEVSALYEAGGDG
                     RALPPATSYRAYLEWLRRRDGEAAREAWRAEFAGADEPTLVAPAHPGAASDVPERVSFE
                     FTEDVTRAVSELARAHGLTVNTVVQGAWALLLARLVGRTDVVFGATVAGRPADIPGVES
                     MVGLFINSLPVRVNPRAEQSVVAMLTDLQARQVALMAHQHLGLPEIRRAAGPGAVFDTL
                     VVYENYPRPPLKEPSPDALSIRPGRKPEDTGHYPLTLVAVPGDRLHGELVYQPGSFTHA
                     WAEEAVASLSDVLARLAADPSAPVARVSVLGGARRERVVRGWNRTEVPVPAATLPQLLR
                     RQVERSREATAIEGELSLSYQELQDEAGRWARYLIGVGVATERRVAVLAPRSAATVTAV
                     LAVSMAGGVFVPVDPGYPPDRVAFLLADTDPSVVLCTRRTRAVVPEGYGGQIVVLDEPE
                     VAEAVAACRPGPVEDRERPLPLVADNAAYVIHTSGSTGTPKGVVVPHAGLANLARAQIE
                     RFAVGPDARVLQFASLSFDAAVSELCMALLSGGTLVLPDETELPPHVTLGEAVRAARAT
                     HVTVPPSVLAAEEDLPAGLRTLVVAGEACPPGLVDRWSAQHRMVNAYGPTEATVCAAMS
                     EPLSAGAGQVPIGRPMANVRAYVLDGFLQPVPPGTTGELYVTGPGVARGYWGRPALTAQ
                     RFVACPFLPGERMYRTGDLARWNGTGELDFVGRADAQVKVRGYRIEPGEVEAVLATHPD
                     VDQAVVVARRDGPGERRLVAYVVPASSGSEQLAVRLVEFAAARLPDHMVPSSFVPLDRL
                     PLTVSGKVDRRALPAPDFAGRVVGREPRTAAEAVLCGLFGEVLGLDRVGVTDGFFALGG
                     DSISSMQLASRARRAGLIVTPRQVFEEKTPERLAAVARPAAAGAAPVADDTGVGEVPWT
                     PVMRELGAAALRPRFAQWTAVGAPAGLRLDVLVTGVAALLDTHDMLRARVLTDDGTEPR
                     LTVRERGSVSAADLVTRVAAQNTAAAIASGGLDEIADRAAREAVLRLDPEAGVMLQVVW
                     VDAGPEQLGRIVLMLHHLAVDGMSWRILLPDLALACEAVAAGQEPALDPVTMSFRRWAR
                     LLVDQASGPERTTELDTWTALLGQPETPLGKRELDPARDTAAAMRRRSWRLPHDEAATL
                     AARTPALFHCGVHEVLLSTLVGAVAQWRGDGVSGVLVDVEGHGRESVEGVDVSRTTGWF
                     TRTHPVRLDVAGLDLGEAQAGGPAAGALLKAVKEQARAVPGDGLGYGLLRHLNPETGPV
                     LAALPRAQIGFNYLGRFSATGTGELPPAAWQMTGDSAIGGSADPDMPSTHTLEAGAAIV
                     DTADGPELTLSLGWAGQILDDAAVERLGQSWLDLLVGLAAHTTAPASGGHTPSDFPLLG
                     LAQSQIEELEAGLADDNL"
     CDS_motif       62..151
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0001"
                     /evalue="2.40E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="39"
                     /protein_start="9"
                     /score="51.8"
                     /tool="antismash"
                     /translation="PPGTVGELYVSGAGLAAGYWDRPALTAERF"
     CDS_motif       233..298
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0002"
                     /evalue="3.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="88"
                     /protein_start="66"
                     /score="35.2"
                     /tool="antismash"
                     /translation="FVGRADAQVKVRGFRVELGEVE"
     CDS_motif       335..391
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0003"
                     /evalue="1.20E+00"
                     /label="C5_LCL_267-296"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="119"
                     /protein_start="100"
                     /score="1.8"
                     /tool="antismash"
                     /translation="VVVAREDVPGERRLVGYVV"
     misc_feature    452..454
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       515..541
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0004"
                     /evalue="5.30E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="169"
                     /protein_start="160"
                     /score="3.8"
                     /tool="antismash"
                     /translation="GKVDRAALP"
     aSDomain        593..790
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48275_PCP.1"
                     /evalue="8.50E-25"
                     /label="IEY95_RS48275_PCP.1"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="252"
                     /protein_start="186"
                     /score="78.8"
                     /tool="antismash"
                     /translation="EAALCELFAEVLGLERVGVEDSFFELGGDSIMSMQLVARARRAGL
                     LLAAQDVFASPSPAELAAVAK"
     aSModule        593..2311
                     /domains="nrpspksdomains_IEY95_RS48275_PCP.1"
                     /domains="nrpspksdomains_IEY95_RS48275_Epimerization.1"
                     /domains="nrpspksdomains_IEY95_RS48275_TIGR01720.1"
                     /incomplete
                     /locus_tags="IEY95_RS48275"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       656..685
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0005"
                     /evalue="1.30E-01"
                     /label="PCP_mE"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="217"
                     /protein_start="207"
                     /score="5.7"
                     /tool="antismash"
                     /translation="SFFELGGDSI"
     aSDomain        848..1783
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48275_Epimerization.1"
                     /evalue="1.30E-125"
                     /label="IEY95_RS48275_Epimerization.1"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="583"
                     /protein_start="271"
                     /score="411.9"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVIDG"
                     /tool="antismash"
                     /translation="VGEVPWTPAMRALGERGRRGRFAQWIVVGSPAGLDRDVLVAGVAA
                     VLDTHDMLRAGVVEADGAEPGLAVRRRGSVPAAPLVSRVDAGDAPAESLDAVADQAARE
                     ATERLDPPAGVLLQIIWVDAGPERTGRLVVVVHHLVIDGLSWRILIPDLQAACEAAAAG
                     REPELPPAGTSFKRWADLLVEEAHAASRIAELQDWTAQLGQPEPPLGTRELDHSLDTAS
                     TMGRRSWTLPAQHAVTLAGRTPALFHCGVHEVLLSTLAGAVTRWRRENGQGGVPGVLVD
                     IEGHGRAPAADAELSRTLGWFSSTHPLRLDT"
     CDS_motif       947..1012
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0006"
                     /evalue="4.00E-02"
                     /label="C2_DCL_024-062"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="326"
                     /protein_start="304"
                     /score="6.3"
                     /tool="antismash"
                     /translation="LDRDVLVAGVAAVLDTHDMLRA"
     CDS_motif       989..1018
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0007"
                     /evalue="1.90E-02"
                     /label="Cy2"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="328"
                     /protein_start="318"
                     /score="7.8"
                     /tool="antismash"
                     /translation="DTHDMLRAGV"
     CDS_motif       1241..1306
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0008"
                     /evalue="1.40E-09"
                     /label="NRPS-E2"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="424"
                     /protein_start="402"
                     /score="30.2"
                     /tool="antismash"
                     /translation="LVVVVHHLVIDGLSWRILIPDL"
     CDS_motif       1730..1777
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0009"
                     /evalue="3.20E-05"
                     /label="NRPS-E5"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="581"
                     /protein_start="565"
                     /score="16.4"
                     /tool="antismash"
                     /translation="LSRTLGWFSSTHPLRL"
     aSDomain        1829..2311
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48275_TIGR01720.1"
                     /evalue="6.80E-38"
                     /label="IEY95_RS48275_TIGR01720.1"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="759"
                     /protein_start="598"
                     /score="121.9"
                     /tool="antismash"
                     /translation="GVLLKAVKEQARAVPGDSLGYGLLRHLNPETGPVLAALPSPQIGF
                     NYLGRFASHGDRHLPPAPWEMSGDAAIGGSVDPDMPAQHTLEAGAAVLDTPAGPELTLT
                     LMWPTGLLDEAEAERLGRHWLDLLAGLAAHTADPGAGGRSPSDFPLLGLGQREIDEL"
     CDS_motif       1847..1909
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0010"
                     /evalue="6.80E-08"
                     /label="NRPS-E6"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="625"
                     /protein_start="604"
                     /score="24.8"
                     /tool="antismash"
                     /translation="VKEQARAVPGDSLGYGLLRHL"
     CDS_motif       1949..1978
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0011"
                     /evalue="2.80E-02"
                     /label="NRPS-E7"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="648"
                     /protein_start="638"
                     /score="7.4"
                     /tool="antismash"
                     /translation="PQIGFNYLGR"
     aSDomain        2330..3220
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48275_Cglyc.1"
                     /domain_subtypes="Cglyc"
                     /evalue="2.20E-141"
                     /label="IEY95_RS48275_Cglyc.1"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1062"
                     /protein_start="765"
                     /score="462.3"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIVADG"
                     /tool="antismash"
                     /translation="LADIWPLSPLQEGLLFHAEYDDLGPDLYEGQRVLALDGPLDTERL
                     RASWEALLARHPILRASFHQRASGEAVQIIARDVQLPWTQADLTGTTEADLAAALDRLF
                     AGERARRLDVTSAPLLRLLLVRLAADRHLLALTSHHIVADGWSLPVIITEVSALYEAGG
                     DGRALPPATSYRAYLEWLRRRDGEAAREAWRAEFAGADEPTLVAPAHPGAASDVPERVS
                     FEFTEDVTRAVSELARAHGLTVNTVVQGAWALLLARLVGRTDVVFGATVAGRPADIPGV
                     ESMVGLFINSLPVRVN"
     aSModule        2330..6922
                     /complete
                     /domains="nrpspksdomains_IEY95_RS48275_Cglyc.1"
                     /domains="nrpspksdomains_IEY95_RS48275_AMP-binding.1"
                     /domains="nrpspksdomains_IEY95_RS48275_PCP.2"
                     /domains="nrpspksdomains_IEY95_RS48275_Epimerization.2"
                     /domains="nrpspksdomains_IEY95_RS48275_TIGR01720.2"
                     /locus_tags="IEY95_RS48275"
                     /monomer_pairings="Tyr -> D-Tyr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2342..2383
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0012"
                     /evalue="1.80E-04"
                     /label="C1_DCL_004-017"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="783"
                     /protein_start="769"
                     /score="13.6"
                     /tool="antismash"
                     /translation="WPLSPLQEGLLFHA"
     CDS_motif       2405..2524
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0013"
                     /evalue="8.30E-18"
                     /label="C2_DCL_024-062"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="830"
                     /protein_start="790"
                     /score="56.7"
                     /tool="antismash"
                     /translation="DLYEGQRVLALDGPLDTERLRASWEALLARHPILRASFHQ"
     CDS_motif       2744..2806
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0014"
                     /evalue="1.30E-10"
                     /label="C3_DCL_135-156"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="924"
                     /protein_start="903"
                     /score="33.7"
                     /tool="antismash"
                     /translation="HHIVADGWSLPVIITEVSALY"
     CDS_motif       3119..3214
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0015"
                     /evalue="9.50E-21"
                     /label="C5_DCL_263-294"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1060"
                     /protein_start="1028"
                     /score="66.2"
                     /tool="antismash"
                     /translation="DVVFGATVAGRPADIPGVESMVGLFINSLPVR"
     CDS_motif       3263..3376
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0016"
                     /evalue="2.40E-19"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1114"
                     /protein_start="1076"
                     /score="61.8"
                     /tool="antismash"
                     /translation="QARQVALMAHQHLGLPEIRRAAGPGAVFDTLVVYENYP"
     aSDomain        3707..4894
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48275_AMP-binding.1"
                     /evalue="9.00E-103"
                     /label="IEY95_RS48275_AMP-binding.1"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1620"
                     /protein_start="1224"
                     /score="335.9"
                     /specificity="substrate consensus: Tyr"
                     /tool="antismash"
                     /translation="RRQVERSREATAIEGELSLSYQELQDEAGRWARYLIGVGVATERR
                     VAVLAPRSAATVTAVLAVSMAGGVFVPVDPGYPPDRVAFLLADTDPSVVLCTRRTRAVV
                     PEGYGGQIVVLDEPEVAEAVAACRPGPVEDRERPLPLVADNAAYVIHTSGSTGTPKGVV
                     VPHAGLANLARAQIERFAVGPDARVLQFASLSFDAAVSELCMALLSGGTLVLPDETELP
                     PHVTLGEAVRAARATHVTVPPSVLAAEEDLPAGLRTLVVAGEACPPGLVDRWSAQHRMV
                     NAYGPTEATVCAAMSEPLSAGAGQVPIGRPMANVRAYVLDGFLQPVPPGTTGELYVTGP
                     GVARGYWGRPALTAQRFVACPFLPGERMYRTGDLARWNGTGELDFVGRADAQVKVR"
     CDS_motif       3887..3928
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0017"
                     /evalue="2.90E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1298"
                     /protein_start="1284"
                     /score="8.2"
                     /tool="antismash"
                     /translation="LAVSMAGGVFVPVD"
     CDS_motif       4145..4204
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0018"
                     /evalue="2.60E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1390"
                     /protein_start="1370"
                     /score="29.1"
                     /tool="antismash"
                     /translation="AYVIHTSGSTGTPKGVVVPH"
     CDS_motif       4688..4777
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0019"
                     /evalue="5.60E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1581"
                     /protein_start="1551"
                     /score="53.8"
                     /tool="antismash"
                     /translation="PPGTTGELYVTGPGVARGYWGRPALTAQRF"
     CDS_motif       4859..4924
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0020"
                     /evalue="2.40E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1630"
                     /protein_start="1608"
                     /score="35.6"
                     /tool="antismash"
                     /translation="FVGRADAQVKVRGYRIEPGEVE"
     CDS_motif       4961..5017
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0021"
                     /evalue="4.10E+00"
                     /label="C5_LCL_267-296"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1661"
                     /protein_start="1642"
                     /score="0.1"
                     /tool="antismash"
                     /translation="VVVARRDGPGERRLVAYVV"
     CDS_motif       5141..5167
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0022"
                     /evalue="1.40E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1711"
                     /protein_start="1702"
                     /score="5.3"
                     /tool="antismash"
                     /translation="GKVDRRALP"
     aSDomain        5219..5416
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48275_PCP.2"
                     /evalue="2.60E-20"
                     /label="IEY95_RS48275_PCP.2"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1794"
                     /protein_start="1728"
                     /score="64.4"
                     /tool="antismash"
                     /translation="EAVLCGLFGEVLGLDRVGVTDGFFALGGDSISSMQLASRARRAGL
                     IVTPRQVFEEKTPERLAAVAR"
     CDS_motif       5282..5311
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0023"
                     /evalue="5.60E-01"
                     /label="PCP_mE"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1759"
                     /protein_start="1749"
                     /score="4.0"
                     /tool="antismash"
                     /translation="GFFALGGDSI"
     aSDomain        5459..6397
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48275_Epimerization.2"
                     /evalue="2.40E-126"
                     /label="IEY95_RS48275_Epimerization.2"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="2121"
                     /protein_start="1808"
                     /score="414.3"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLAVDG"
                     /tool="antismash"
                     /translation="VGEVPWTPVMRELGAAALRPRFAQWTAVGAPAGLRLDVLVTGVAA
                     LLDTHDMLRARVLTDDGTEPRLTVRERGSVSAADLVTRVAAQNTAAAIASGGLDEIADR
                     AAREAVLRLDPEAGVMLQVVWVDAGPEQLGRIVLMLHHLAVDGMSWRILLPDLALACEA
                     VAAGQEPALDPVTMSFRRWARLLVDQASGPERTTELDTWTALLGQPETPLGKRELDPAR
                     DTAAAMRRRSWRLPHDEAATLAARTPALFHCGVHEVLLSTLVGAVAQWRGDGVSGVLVD
                     VEGHGRESVEGVDVSRTTGWFTRTHPVRLDVA"
     CDS_motif       5594..5638
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0024"
                     /evalue="5.30E-04"
                     /label="Cy2"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1868"
                     /protein_start="1853"
                     /score="12.7"
                     /tool="antismash"
                     /translation="LLDTHDMLRARVLTD"
     CDS_motif       5867..5929
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0025"
                     /evalue="7.60E-10"
                     /label="NRPS-E2"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="1965"
                     /protein_start="1944"
                     /score="31.1"
                     /tool="antismash"
                     /translation="VLMLHHLAVDGMSWRILLPDL"
     CDS_motif       6338..6388
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0026"
                     /evalue="3.20E-06"
                     /label="NRPS-E5"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="2118"
                     /protein_start="2101"
                     /score="19.5"
                     /tool="antismash"
                     /translation="DVSRTTGWFTRTHPVRL"
     aSDomain        6437..6922
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48275_TIGR01720.2"
                     /evalue="3.50E-39"
                     /label="IEY95_RS48275_TIGR01720.2"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="2296"
                     /protein_start="2134"
                     /score="126.1"
                     /tool="antismash"
                     /translation="AGALLKAVKEQARAVPGDGLGYGLLRHLNPETGPVLAALPRAQIG
                     FNYLGRFSATGTGELPPAAWQMTGDSAIGGSADPDMPSTHTLEAGAAIVDTADGPELTL
                     SLGWAGQILDDAAVERLGQSWLDLLVGLAAHTTAPASGGHTPSDFPLLGLAQSQIEEL"
     CDS_motif       6458..6520
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0027"
                     /evalue="1.30E-09"
                     /label="NRPS-E6"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="2162"
                     /protein_start="2141"
                     /score="30.2"
                     /tool="antismash"
                     /translation="VKEQARAVPGDGLGYGLLRHL"
     CDS_motif       6560..6589
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48275_0028"
                     /evalue="5.00E-02"
                     /label="NRPS-E7"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="2185"
                     /protein_start="2175"
                     /score="6.7"
                     /tool="antismash"
                     /translation="AQIGFNYLGR"
     aSDomain        6872..6928
                     /aSDomain="NRPS-COM_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48275_NRPS-COM_Cterm.1"
                     /evalue="2.80E-07"
                     /label="IEY95_RS48275_NRPS-COM_Cterm.1"
                     /locus_tag="IEY95_RS48275"
                     /protein_end="2298"
                     /protein_start="2279"
                     /score="22.2"
                     /tool="antismash"
                     /translation="PSDFPLLGLAQSQIEELEA"
     gene            7097..>8517
                     /locus_tag="IEY95_RS48280"
     CDS             7097..>8517
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (1-24). E-value: 7.6e-10.
                     Score: 29.9. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48280_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Cglyc (5-304). E-value: 3.6e-148. Score:
                     484.5. Matches aSDomain:
                     nrpspksdomains_IEY95_RS48280_Cglyc.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980926.1"
                     /locus_tag="IEY95_RS48280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_229703876.1"
                     /sec_met_domain="Condensation (E-value: 7.5e-72, bitscore:
                     229.0, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSLVEDVWPLSPLQAGLLFHAAFDDQGPDVYTVQSALDIDGPL
                     DTGRLRASWEALLTRHAALRACFRQVSGAQMVQVIAREVVLPWRTEDVSGLPAPEAPAA
                     LEHMVRSERSEPFDLAAAPLLRLLLIRLGERRHRLVMTSHHILMDGWSAPIMIEELSRI
                     YAAGGDASVLPPVTSYREYLAWLARQDKDAARAAWQEELAGADEPTLVTPAVPDRLPVF
                     PDRVTGDLPETVTRSVTELARAHGLTVNTVVQGAWALVLALLAGRTDVVFGATVAGRPP
                     ELPGVETMVGLLINTLPVRVPLDGAQPFVEMLRALQSRQSALLSHHHLGLLEIQKAAGP
                     GAAFDTLIVYESFPRPPATDSSPNGSSVTIRPSGTAREAAHYPFTLVVAPGDRMRFTLE
                     YRPDLFDRDLAESVLRYLERVLERVVADPSVVVGRVGVVDVEERVSLGEVHGGVSVPEL
                     IRGRVVSAPDAVAVVG"
     aSDomain        7100..7168
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48280_NRPS-COM_Nterm.1"
                     /evalue="7.60E-10"
                     /label="IEY95_RS48280_NRPS-COM_Nterm.1"
                     /locus_tag="IEY95_RS48280"
                     /protein_end="24"
                     /protein_start="1"
                     /score="29.9"
                     /tool="antismash"
                     /translation="TRSLVEDVWPLSPLQAGLLFHAA"
     aSDomain        7112..8008
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS48280_Cglyc.1"
                     /domain_subtypes="Cglyc"
                     /evalue="3.60E-148"
                     /label="IEY95_RS48280_Cglyc.1"
                     /locus_tag="IEY95_RS48280"
                     /protein_end="304"
                     /protein_start="5"
                     /score="484.5"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHILMDG"
                     /tool="antismash"
                     /translation="VEDVWPLSPLQAGLLFHAAFDDQGPDVYTVQSALDIDGPLDTGRL
                     RASWEALLTRHAALRACFRQVSGAQMVQVIAREVVLPWRTEDVSGLPAPEAPAALEHMV
                     RSERSEPFDLAAAPLLRLLLIRLGERRHRLVMTSHHILMDGWSAPIMIEELSRIYAAGG
                     DASVLPPVTSYREYLAWLARQDKDAARAAWQEELAGADEPTLVTPAVPDRLPVFPDRVT
                     GDLPETVTRSVTELARAHGLTVNTVVQGAWALVLALLAGRTDVVFGATVAGRPPELPGV
                     ETMVGLLINTLPVRVPLD"
     CDS_motif       7124..7165
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48280_0001"
                     /evalue="1.10E-04"
                     /label="C1_DCL_004-017"
                     /locus_tag="IEY95_RS48280"
                     /protein_end="23"
                     /protein_start="9"
                     /score="14.3"
                     /tool="antismash"
                     /translation="WPLSPLQAGLLFHA"
     CDS_motif       7187..7306
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48280_0002"
                     /evalue="1.90E-19"
                     /label="C2_DCL_024-062"
                     /locus_tag="IEY95_RS48280"
                     /protein_end="70"
                     /protein_start="30"
                     /score="62.0"
                     /tool="antismash"
                     /translation="DVYTVQSALDIDGPLDTGRLRASWEALLTRHAALRACFRQ"
     CDS_motif       7526..7588
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48280_0003"
                     /evalue="9.50E-12"
                     /label="C3_DCL_135-156"
                     /locus_tag="IEY95_RS48280"
                     /protein_end="164"
                     /protein_start="143"
                     /score="37.3"
                     /tool="antismash"
                     /translation="HHILMDGWSAPIMIEELSRIY"
     CDS_motif       7631..7666
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48280_0004"
                     /evalue="1.90E-03"
                     /label="C4_DCL_171-183"
                     /locus_tag="IEY95_RS48280"
                     /protein_end="190"
                     /protein_start="178"
                     /score="10.9"
                     /tool="antismash"
                     /translation="YREYLAWLARQD"
     CDS_motif       7802..7855
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48280_0005"
                     /evalue="8.60E-01"
                     /label="C5_LCL_267-296"
                     /locus_tag="IEY95_RS48280"
                     /protein_end="253"
                     /protein_start="235"
                     /score="2.3"
                     /tool="antismash"
                     /translation="RSVTELARAHGLTVNTVV"
     CDS_motif       7901..7996
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48280_0006"
                     /evalue="4.10E-21"
                     /label="C5_DCL_263-294"
                     /locus_tag="IEY95_RS48280"
                     /protein_end="300"
                     /protein_start="268"
                     /score="67.4"
                     /tool="antismash"
                     /translation="DVVFGATVAGRPPELPGVETMVGLLINTLPVR"
     CDS_motif       8045..8158
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS48280_0007"
                     /evalue="2.50E-15"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="IEY95_RS48280"
                     /protein_end="354"
                     /protein_start="316"
                     /score="48.8"
                     /tool="antismash"
                     /translation="QSRQSALLSHHHLGLLEIQKAAGPGAAFDTLIVYESFP"
ORIGIN
        1 tatcgggcgc ccgctgtctc accgcaggat ctttgtgctg gacgcgttct tgcagccggt
       61 cccgcccggc acggtgggtg aactgtatgt atccggtgcc gggctggctg ccggttactg
      121 ggaccgtccg gcgctgaccg ccgagcgttt tgtggcgtgc ccgttcgctg cgggggagcg
      181 gatgtatcgc accggggatc tggtgcgctg gacggacgac ggtgagttgc tgttcgtcgg
      241 ccgcgcggac gcgcaggtga aggtgcgggg tttccgggtc gagctgggtg aggtcgaggc
      301 ggtgctgtcc gcgcatccgg ccgtgtccca ggccgtggtg gtcgcccgcg aggacgttcc
      361 gggtgagcgc cgcctggtcg gttatgtcgt gcccgaggac ccgcaggccg gtgtgcacgc
      421 cgagcacgcc cgcgaggagg cggcgaggca gttaccggac tacatggtgc ccgccgccgt
      481 cctcgttctc gacaagttgc cgctcacccg taacggcaaa gtggaccgcg ccgctctgcc
      541 tgccccggac tttgccggca aggtcaccga gcgggcgccg cgcaccgacg ccgaggccgc
      601 gctctgtgag ctgttcgccg aggtgctggg gcttgaacgg gtcggcgtcg aggacagttt
      661 cttcgagctc ggcggcgact cgatcatgtc gatgcagctc gtcgcacgcg ctcgccgcgc
      721 cggtctgctc ctggcggcgc aggacgtctt cgcatcaccg agccccgccg aactcgccgc
      781 ggtggccaaa cctttggacg agacgacggg cacaggagga ccctctggac ccctctccga
      841 accggacgtg ggcgaggtgc cctggacgcc ggcgatgcgg gcgctcgggg agcgaggtcg
      901 tcgcggcagg ttcgcacagt ggatcgttgt cggctctccg gccggactgg accgggacgt
      961 gctggtggcc ggcgtggcgg ccgtactcga cacgcacgac atgctgcgag caggcgtcgt
     1021 ggaggccgac ggggcggagc ccgggctggc ggtgaggagg cgcggctcgg taccggccgc
     1081 accgctcgtc tcccgcgtgg acgcgggcga tgctccggcc gagtccctgg acgccgtcgc
     1141 ggaccaggcc gcgcgcgaag cgacggagcg cctggatcct ccggcgggtg tgctgctcca
     1201 gatcatctgg gtggacgccg gtcccgagcg gaccggacga ctggtcgtcg tcgtgcacca
     1261 cctggtgatc gacggactgt cgtggcggat actgatcccg gacctgcaag ccgcctgcga
     1321 agccgcggcg gccgggcggg agcccgaact acccccggcg ggaacgtcgt tcaaacggtg
     1381 ggcggacctg ctcgtcgagg aggcccacgc ggcaagccgg atcgcggaac tccaggactg
     1441 gacggcccag ctggggcagc cggaaccgcc gctcggaaca agggagttgg accactccct
     1501 ggacaccgcg tcgaccatgg gccgccgctc ctggaccctg cccgcccagc acgcggtcac
     1561 cctggccggc cggaccccgg cgctcttcca ctgcggtgtg cacgaggtgc tgctgtcgac
     1621 gctggcggga gcggtcacgc gatggcgccg ggagaacggg cagggcggcg tccccggggt
     1681 gctcgtggac atcgaagggc acggccgggc gccggccgcg gacgccgaac tctcccgcac
     1741 gctcggttgg ttcagcagca cgcaccccct tcgcctcgac acggtcggca tagatctgga
     1801 cgacgtactg gccggtggcc ctgcggccgg ggtgctgctg aaggcggtga aggagcaggc
     1861 gcgggcggtg cccggggaca gtctcggcta cgggctgctg cgtcacctca acccggagac
     1921 gggcccggtg ctcgccgcac tgccgagtcc gcagatcggc ttcaactacc tgggccgctt
     1981 cgcatcccac ggtgatcgcc accttccgcc ggcaccctgg gagatgtccg gcgacgcggc
     2041 gatcggcggc tccgtcgatc ccgacatgcc cgctcagcac accctggagg cgggcgccgc
     2101 cgtactggac accccggcag gtcccgaact gaccctcacc ctcatgtggc ccaccggcct
     2161 gctcgacgag gcggaggccg aacggctcgg ccgccactgg ctggacctgc tggcggggct
     2221 ggccgcgcac accgccgacc cgggagcagg tggacgtagc ccctccgact tccccctcct
     2281 cggcctcggc cagcgagaga tcgacgaact ggaaagcctg gtaccggagc tggcggacat
     2341 ctggccgctg tcgccgctcc aggaagggct gctgttccac gcggagtacg acgacctagg
     2401 gccggacctg tacgaagggc agcgcgtcct ggccctggac ggaccgctgg acacggagcg
     2461 gctgcgggca tcctgggagg ccctgctcgc ccggcacccg atcctgcggg cgagcttcca
     2521 ccaacgcgcc tcgggcgagg cggtccagat catcgcacgt gacgtccaac ttccctggac
     2581 gcaggccgac ctgaccggga cgacggaagc ggacctcgcg gcggccctcg accggctgtt
     2641 cgcgggcgag cgggcccggc gcctggacgt gacctccgcc ccgctcctca ggctgctgct
     2701 cgtccggctc gcggcggacc ggcacctcct cgcgctgacc agccaccaca tcgtcgcgga
     2761 cggctggtcg cttccggtca tcatcaccga ggtgtccgcg ctctacgaag cgggcggcga
     2821 cgggcgggca ctgccgcccg cgacctcgta ccgcgcatac ctggaatggc tgcgccgacg
     2881 ggacggcgag gcggcgcggg aggcgtggcg ggcggagttc gccggagccg acgagccgac
     2941 gctcgtggcg cccgcccacc cgggggcggc atccgacgta ccggaacgcg tgtcgttcga
     3001 gttcaccgag gacgtcaccc gcgccgtgtc cgagctggcc cgcgcgcacg gactgaccgt
     3061 gaacacggtg gtgcagggcg cctgggcgct gctgctcgcc cggctcgtgg ggcgtacgga
     3121 cgtggtgttc ggcgcgaccg tcgcaggacg ccccgcggac ataccgggag tcgagtcgat
     3181 ggtcgggctc ttcatcaact ccctgcccgt gcgggtgaat ccgcgggcgg agcagtccgt
     3241 cgtcgcgatg ctgaccgacc tccaggcgcg gcaggtcgcg ctgatggccc accagcatct
     3301 cggccttccc gagatccgca gggccgccgg cccgggcgcc gtcttcgaca cgctggtcgt
     3361 gtacgagaac tacccgcgcc cgcccctcaa ggagccctcg ccggacgccc tgtccatccg
     3421 ccccggacgg aaaccggagg acaccgggca ctacccgctg acgttggtcg cggttcccgg
     3481 agaccgactg cacggcgagc tcgtatatca gccgggctcg ttcacgcacg cctgggccga
     3541 ggaggcggtg gcgtcgctgt ccgacgtcct cgcgcggctg gcggcggacc cctcggcgcc
     3601 agtggcgcgt gtgtccgtcc tcggcggagc acgccgtgaa cgcgtggtgc gcggatggaa
     3661 ccgcaccgag gtgcccgtgc ccgccgcgac actgccccag ctgctgcgcc ggcaggtgga
     3721 acggtcacgg gaggcgaccg ccatcgaggg cgaactgtcg ctgtcgtacc aggagttgca
     3781 ggacgaggcc ggccggtggg cgcgctatct gatcggcgtg ggcgtcgcga ccgaacgccg
     3841 ggtggcggtg ctcgcaccgc gatcggcggc gacggtgacc gccgtcctcg cggtgtccat
     3901 ggcgggcggc gtcttcgtcc cggtggaccc cggatacccg ccggatcggg tcgccttcct
     3961 cctggcggac accgacccgt ccgtcgtgct gtgcacccgg cggacccggg ccgtggtgcc
     4021 cgaggggtac ggcgggcaga tcgtcgtcct ggacgagccg gaggtcgccg aagccgtcgc
     4081 cgcatgccgt ccggggcccg ttgaggacag ggagcgcccg ctgccgctcg tcgcggacaa
     4141 cgccgcgtac gtcatccaca cctccggatc gaccggcaca ccgaaaggcg tggtggtgcc
     4201 gcacgcgggt ctcgccaacc tggcgcgggc acagatcgaa cgcttcgcgg tgggcccgga
     4261 tgcccgggtg ctccagttcg cctcgctcag cttcgacgcc gcggtctccg agctgtgcat
     4321 ggctctgctc tcgggcggca cacttgtact gcccgacgag accgagctgc ccccgcatgt
     4381 gaccctcggc gaggcggtgc gcgcggcccg ggcgacccat gtcacggtgc cgccgagcgt
     4441 cctcgccgcg gaggaggacc tgcccgccgg cctgcgaacc ctggtggtgg cgggcgaggc
     4501 atgcccgccg ggcctggtgg accggtggtc cgcacaacac cgcatggtga acgcgtacgg
     4561 acccaccgag gcgaccgtgt gcgcggcgat gagcgaaccg ctgtcagcgg gcgcaggcca
     4621 ggtgccgatc ggccggccga tggcgaacgt acgcgcatac gtcctcgacg gcttcctgca
     4681 accggtacca ccgggaacga ccggcgaact gtatgtgacg gggcccggtg tggcccgcgg
     4741 gtactgggga cgcccggctc tcaccgcaca gcggttcgtg gcctgcccgt tcctgccggg
     4801 ggagcggatg taccggaccg gtgacctggc acgctggaac ggcaccggcg aactggactt
     4861 cgtcggccgg gcggacgccc aggtcaaggt ccgcggatac cgcatcgaac caggagaggt
     4921 cgaagccgta ctggccaccc atccggacgt cgaccaggcc gtggtggtgg cgcgccggga
     4981 cggtcccggc gagcggcggc tggtcgcgta cgtcgtccca gcatcctcgg gctccgagca
     5041 actggcggtg cgactcgttg agttcgccgc cgctcgcctc ccggatcaca tggtgccctc
     5101 gtcgttcgtg ccgctggacc gcctgccgct gaccgtgagc ggaaaggtgg accgccgggc
     5161 cctgccggcg cccgacttcg cgggccgggt ggtgggacgg gagccacgca cagcggccga
     5221 agcggtgctg tgcggcctct tcggcgaagt cctcggactg gaccgggtcg gcgtgacgga
     5281 cggcttcttc gcgttgggcg gcgactccat ctcctcgatg cagctggcgt cccgcgcccg
     5341 ccgcgccggg ctgatcgtca ccccccggca ggtcttcgag gagaagaccc ccgaacgcct
     5401 cgcggccgtg gcacgcccgg ccgcggccgg tgcggcgccc gtcgccgacg acaccggggt
     5461 gggcgaggtg ccgtggaccc ccgtgatgcg ggagctgggc gcggcggccc tgcggccccg
     5521 gttcgcgcag tggaccgcgg tcggcgcccc ggccggtctg cggctcgacg tgctggtgac
     5581 cggcgtggcc gccctgctcg acacccacga catgctccgc gcgcgggtac tcaccgacga
     5641 cggcacggag ccgcggctga cggtccgcga gcgcggctcg gtttccgcag cggacctcgt
     5701 cacccgtgtc gccgcgcaga acacggccgc ggcgatcgct tcgggcggcc tggacgagat
     5761 cgcggaccgc gccgcccggg aggccgtcct gcgcctcgac ccggaagcgg gcgtgatgct
     5821 ccaggtggtc tgggtcgatg cgggccccga gcagctcggc cgcatcgtcc tgatgctcca
     5881 ccacctggcc gtcgacggca tgtcctggcg catcctgctg cccgacctcg ccctggcgtg
     5941 cgaggcggtg gcggcggggc aggaaccggc cctcgatccc gtgacgatgt cgttcaggcg
     6001 ctgggcacgc ctcctggtcg accaggcctc cggaccggag cgcaccacgg aactcgacac
     6061 ctggacggca ctcctgggac agcccgagac acccttgggc aagcgggagt tggaccccgc
     6121 ccgggacacc gcggcagcca tgcgccgccg ctcctggcgg ctgccgcacg acgaggcggc
     6181 caccctggcg gcccgtacgc ccgcgctgtt ccactgcggt gtgcacgagg tgctcctgtc
     6241 gacgctggtg ggtgcggtcg cgcagtggcg tggggacggt gtgtccgggg ttctggtcga
     6301 tgtggagggg catggacgcg agtccgtcga aggggtcgat gtgtcgagga cgacgggctg
     6361 gttcacccgt acgcatccgg tacgtctcga tgtggccggc ctcgacctgg gggaggcgca
     6421 ggcaggtggt ccggcggccg gggcgctgct gaaggcggtg aaggagcagg cgcgggcggt
     6481 gccgggtgac gggctcggct acggattgct gcgtcacctc aacccggaga cggggccggt
     6541 gctcgccgcg ctgccgcgtg cgcagatcgg cttcaactac ctgggccgct tcagtgcgac
     6601 cggcaccggt gaactcccgc ccgccgcctg gcagatgacc ggagacagtg cgatcggcgg
     6661 ctccgcggac ccggacatgc cgtccacgca cacgctggaa gcgggcgccg ccatcgtgga
     6721 cactgctgac gggcccgaac tcaccctctc ccttggttgg gcgggccaga tcctcgacga
     6781 cgccgcggtg gaacgcctcg gacagagctg gctcgacctg ctcgtcggcc tcgccgccca
     6841 caccacggcc cccgcctccg gtggccacac tccgtccgac ttccccctgc tcggtctcgc
     6901 ccagagccag atcgaggaac tcgaagccgg gctcgccgac gacaacctgt gacggaccgc
     6961 ttctgagtgc ccgcttccgt aagggcccga tgccccaagt gctccatccc tcaagtgctc
     7021 gttcgcgcaa ctgctgggct ccgcaagtgc tcgatcccgt acgtgctcga agcaactcgc
     7081 tctgaggaga gaagcgatga cccgatccct tgtcgaggac gtgtggccgc tgtcgccgtt
     7141 gcaggccggc ctgctgttcc acgccgcctt cgacgaccag ggtccggacg tgtacaccgt
     7201 gcagtccgcg ctcgacatcg acggccccct cgacacgggg cgcctgcggg cgtcgtggga
     7261 ggctctcctg acccggcacg ccgcgctgcg cgcctgtttc cgtcaggtca gcggggcgca
     7321 gatggtgcag gtcatcgctc gggaggtcgt gctgccctgg cgcacggagg acgtctcggg
     7381 tcttcccgca cccgaggcgc cggccgccct ggaacacatg gtgcgaagcg agcggtccga
     7441 gcccttcgac ctggctgccg cgcccctgct gcgactgctc ctgattcggc tcggcgagcg
     7501 gcgccaccgc ctggtgatga cgagccacca catcctcatg gacggctggt cggccccgat
     7561 catgatcgaa gagctgtcac ggatctacgc cgcggggggc gacgcgtccg tcctgccacc
     7621 tgtgacgtcc taccgggagt acctggcgtg gctggcccgg caggacaagg acgccgcccg
     7681 agccgcctgg caggaggagc tggccggcgc ggacgaaccg acgctggtga ccccggccgt
     7741 tcccgaccgg ctccctgtct tccccgaccg ggtgaccgga gacctcccgg aaacggtcac
     7801 ccggagcgtg accgagctgg cccgcgccca cggtctgacg gtgaacacgg tggtgcaggg
     7861 tgcctgggcg ctggtcctgg cgctcctcgc cgggcggacg gacgtggtgt tcggcgcgac
     7921 ggtggcgggc cgccccccgg aactcccggg tgtggagacg atggtgggcc tgctcatcaa
     7981 caccctgccc gtgcgggtgc cgctcgacgg tgctcagccg ttcgtggaga tgctccgtgc
     8041 gctccagagc cgtcagtccg cgctgctgtc gcaccaccac ctcggccttt tggagataca
     8101 gaaggccgcg ggcccgggag ccgccttcga cacgctcatc gtctacgaga gcttcccccg
     8161 cccgcccgcc acggactcct ccccgaacgg cagctccgtc accatcaggc cgtccggcac
     8221 ggcgcgcgag gcggcccact atccgttcac tctggtcgtc gcccccggcg accggatgcg
     8281 cttcaccctc gaataccgcc ccgacctgtt cgaccgcgat ctcgccgaat cggtgctgcg
     8341 atacctggaa cgtgtgctgg agcgggtggt ggctgatccg tccgtggtgg tgggacgggt
     8401 cggggtggtg gacgttgaag aacgtgtatc cctgggtgag gtgcacggag gggtgtcggt
     8461 gccggagttg atccgtgggc gggtggtttc ggcgccggat gcggtggcgg tggtggg
//
