LOCUS       NZ_BMMM01000020        22074 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces albiflavescens strain CGMCC 4.7111 sequence20, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMM01000020
VERSION     NZ_BMMM01000020.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces albiflavescens
  ORGANISM  Streptomyces albiflavescens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 177232)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 100X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645835.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:24:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,828
            CDSs (total)                      :: 9,745
            Genes (coding)                    :: 9,386
            CDSs (with protein)               :: 9,386
            Genes (RNA)                       :: 83
            rRNAs                             :: 1, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 102 of 359
            Pseudo Genes (incomplete)         :: 321 of 359
            Pseudo Genes (internal stop)      :: 17 of 359
            Pseudo Genes (multiple problems)  :: 80 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:54:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 90991
            Orig. end                         :: 113065
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMM01000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22074
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="1"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22074
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22074
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12074](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12074
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(650..664)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(801..2348)
                     /locus_tag="IEY95_RS39665"
                     /old_locus_tag="GCM10011579_080730"
     CDS             complement(801..2348)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018853680.1"
                     /locus_tag="IEY95_RS39665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080730"
                     /product="glycosyltransferase family 39 protein"
                     /protein_id="WP_229703665.1"
                     /transl_table=11
                     /translation="MALFAPAVLSLALGLWGVRRGGSMWRDEAVTYDMARRSLPDLWST
                     LAGVDAVHGLYYLFMHVLFMVSGGLDPLLVLRLPSVLATVAAAGTVALLGHRLAGPRAG
                     LLAGTVFAVLPQVQRYGQEGRSYAVVCALVVWATYLLARAVRSRGGGRAWAAYGAVLLA
                     ACLLHEFAVLALAAHAPAVPRGARRGWARAAVTVLVAMAPLGALSLSQSDQVSWIGGPG
                     TGAYAGFAGLAVLGVACARILGLGAARRSRQPMVANRSAPHNRPAVPANRSAPHNRRPK
                     PTEAPTLTPRPPRFATSAASHPRLPALGLALLVLPALLLLLVSLVKPLYVDRYVLYGQT
                     GTALLAGAALDRLIRAAGRIRTVALVGAGAAVLALIPVTLQLRTPESRTDDVTAVARAV
                     AEAGAQGDGVLYMPARRRVWSLPDPGSVRGLRDLALERGPVASHTLYGTEVPALVIRAR
                     LLATPRVVAVRDPAGQPLDRTPREIVKRRVLALYFEECGTRRVRGARVTVYAHPGEC"
     misc_feature    2326..2341
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 25.13"
                     /tool="antismash"
     gene            2597..6157
                     /locus_tag="IEY95_RS39670"
                     /old_locus_tag="GCM10011579_080740"
     CDS             2597..6157
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138697.1"
                     /locus_tag="IEY95_RS39670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080740"
                     /product="WD40 repeat domain-containing protein"
                     /protein_id="WP_229703666.1"
                     /transl_table=11
                     /translation="MGRREKPVDPAEGAVPRFAHELRKLRDDAGTPTYRAMARHAGYSG
                     PTLSAAAAGERLPTLPVLLAYVTACGGDTAAWERRWRETLATEAGTRAPDDADSPYPGL
                     ARFEPADRDRFHGRDDLIAELLELVARRRISAVVGASGSGKSSLLRAGLIPALRERTAE
                     GRTAPGTPGARTPSVAASGAPVIDPPGPSPAPLAAIRVLTPGAHPARTHDALFSPHDAP
                     GDTLLVIDQFEEVFALCTDPAERALFIERLLTALDPDSRLRVIIGVRADFYGRCAEHGR
                     LAEALRDSTLLVGPMTAQRLREAVVRPAALRRLVVERALTARIVADVADEPGGLPLMAH
                     ALREIWRRRNGRTLTLAAYESVGGVEGAVAHTAEELYARCTPAEAAAVRALLLRLVNPG
                     DGAEDTRRPVDRAELGSEETTAEVLERLVRARLLTVDGDTVDLAHEALIGAWPRLRGWV
                     DEDRERLRLHRRLTEAAHTWHELNRDTGALYRGVRLTAAQEEFGARQDELSPLERDFLA
                     ASIEAYERGRRVADRATRRLRGLTVGLAVLLCLAVVAGVAAWRQSGVNARQRDEAEARR
                     VAAFAGTLRATDPRTAMRLALAAWRTADLPETREAVRQAAAQSEQDAFTQPAQVRALNA
                     PYWLGTDGRILTTVVRDTVVQWDVRSHRQLREVALPGLSGRIVDVSADARLIAYHGRSG
                     ATVRDLTNGENHRIESGSWTDSDGAFGSSGRTFVVRRLDRASDGRRATLEVWDIRRQRV
                     LFRYAQGDPDGPLPLLSPNDRFLAWCTHEGEQLRIWDVVERRRVATEPPARTQRLLCQS
                     DEPTFTPDNRALAAGTADGVVTWDFHADRARPLLPMPGEGALSVEFDPTGTYALTWSPG
                     SLALWRTDLPAPADDGPREPLLTFPVDTPAVTAIRLDPSEGVLRFREGSEAGVVRTLSL
                     RGLVGPAWRKKARTVAAFDSAGNPAEPAERPEVRAVAADGTVHTAVSTRDGIRVTRQGA
                     QPGSHVIGERTEGPAAIDPAGRTVVTFEGVLIDVATGRRRQGFEGEDLLPTVSFSPDGR
                     FLAAADVQGRLTLWDGGGRHRIAVLATADSTVERPALAFSADGSLVAASRADGSVRVWE
                     TASPRLQGAALPVGDGPVLAVGFTPGGRELHIATAHMPLRSVQSAPGGAAAEVCARADG
                     GATRAEWSRYLPDVPYRRTC"
     misc_feature    3065..3067
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6248..6949
                     /locus_tag="IEY95_RS39675"
                     /old_locus_tag="GCM10011579_080750"
     CDS             6248..6949
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-168). E-value: 7.8e-10. Score:
                     30.9. Matches aSDomain:
                     nrpspksdomains_IEY95_RS39675_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141314.1"
                     /locus_tag="IEY95_RS39675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080750"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_189191094.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 4.9e-08,
                     bitscore: 25.6, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDSPVALITGGGSGIGAAVARRLLDAGHRVTVTGRGEKRLHAFA
                     EELGRPEGLLTIAGNAAEYDQVQAAVEATLKEFGRLDTVVASAGFATHDTVAEGDPAGW
                     SEMVLTNVLGPALLIRASIDALKETRGRIVLVGSVAGHIHTPGNIYGATKWAVTGLAEN
                     TRRQVTEFGVGVTLISPGRVETPFWDSYGSLPPGHLLTADQLAESIVWAIGQPEGVDVN
                     TVVVRPIGQPV"
     aSDomain        6263..6751
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS39675_PKS_KR.1"
                     /evalue="7.80E-10"
                     /label="IEY95_RS39675_PKS_KR.1"
                     /locus_tag="IEY95_RS39675"
                     /protein_end="168"
                     /protein_start="5"
                     /score="30.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGGGSGIGAAVARRLLDAGHRVTVTGRGEKRLHAFAEELGR
                     PEGLLTIAGNAAEYDQVQAAVEATLKEFGRLDTVVASAGFATHDTVAEGDPAGWSEMVL
                     TNVLGPALLIRASIDALKETRGRIVLVGSVAGHIHTPGNIYGATKWAVTGLAENTRRQV
                     "
     CDS_motif       6269..6337
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS39675_0001"
                     /evalue="9.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="IEY95_RS39675"
                     /protein_end="30"
                     /protein_start="7"
                     /score="15.2"
                     /tool="antismash"
                     /translation="LITGGGSGIGAAVARRLLDAGHR"
     gene            complement(7031..7726)
                     /locus_tag="IEY95_RS39680"
                     /old_locus_tag="GCM10011579_080760"
     CDS             complement(7031..7726)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073097.1"
                     /locus_tag="IEY95_RS39680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080760"
                     /product="glycoside hydrolase family 75 protein"
                     /protein_id="WP_189191095.1"
                     /transl_table=11
                     /translation="MRTRPLTLAAASGAALLATALLPANASGTVNPRSAQEGSVSAADL
                     LAKVTSCSQISNGKYKTDDETSATIPVCGKNGAVFWKADMDIDCDGQVTSKCNGDTDPW
                     FQDDTAFHQSDGKPLRADSLPYVVVPSTSSIWKYTSSGIKGGGVVAVIYNNKVEYAVVG
                     DTGPTKIIGEASYATAKALGIDPDPETGGTDSGVTYILFKNSQVSPIESHSAAVSLGDS
                     LAKKFLQNN"
     misc_feature    complement(7664..7666)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(7826..7842)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.6"
                     /tool="antismash"
     gene            7918..8529
                     /locus_tag="IEY95_RS39685"
                     /old_locus_tag="GCM10011579_080770"
     CDS             7918..8529
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007494912.1"
                     /locus_tag="IEY95_RS39685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080770"
                     /product="hypothetical protein"
                     /protein_id="WP_189191096.1"
                     /transl_table=11
                     /translation="MFVRTVYATGDPVTIDTAIKSLNTRGRDLLEDRPGYRGSSIFVDR
                     KLGKLFVVSWWESEEARRNSEEVLRERRAALLEPFAVTLAVDNYEAVVFHPVRQPQAGG
                     GLRLSRLEFDPADADLLADTFRATVVPQLENLPGLARASLVIDRERGRGLVGVVFVDRE
                     SLVASRGPQSAARHEGAAKAHVTVTGLEEFEVVFTDVRGG"
     gene            complement(8680..9471)
                     /locus_tag="IEY95_RS39690"
                     /old_locus_tag="GCM10011579_080780"
     CDS             complement(8680..9471)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191514.1"
                     /locus_tag="IEY95_RS39690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080780"
                     /product="aldo/keto reductase"
                     /protein_id="WP_189191150.1"
                     /transl_table=11
                     /translation="MPQLGFGVWQVPDDEAERAVATALEAGYRSIDTAAIYGNEKGTGK
                     AITASGIARKDLFVTTKLWNSDQGYDSTLRAFDASLEKLGLEYIDLYLIHWPLPSRGKY
                     IDTYKAFERLYADGRAKAIGVSNFLPEHLEKLIDATSVIPAVNQIELHPHLQQHAAREY
                     HAERGIATEAWSPLGSGKGLLEIPAIVAIAQKHGRTPAQIVLRWHLQLENIVIPKSVTP
                     SRIKENINVFDFSLDTEDIAAITALSEDRRLGPDPATFDMG"
     gene            9839..9982
                     /locus_tag="IEY95_RS39695"
     CDS             9839..9982
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_147995344.1"
                     /locus_tag="IEY95_RS39695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_189191097.1"
                     /transl_table=11
                     /translation="MNEQLASEASGTQSTIRETSEERVWETPGYLVVETALEVTAYALG
                     ER"
     gene            10001..10723
                     /gene="pqqC"
                     /locus_tag="IEY95_RS39700"
                     /old_locus_tag="GCM10011579_080800"
     CDS             10001..10723
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559516.1"
                     /locus_tag="IEY95_RS39700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080800"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_189191098.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.1e-85, bitscore:
                     279.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTTVRDDGVAAPWRTPEFTERLRAVAEERYHDRHPFNIRMHQG
                     ELTPAELRRWIANRFHYQRHIPVKDALIVAKLDQPALRRAWLRRIQDHDGTADGEGGIE
                     RWLRLGEAVGLDRPTLWDATRVLPGVRLAVEGYVNFCRLRPALDAVAASLTELSAPSLM
                     RTRIAAFERHYPWIEAEGLAYFRARIGQGGRDSEEALALVHAWARTREQQERAVAALAF
                     KCEVLWALLDAVDRGGGS"
     misc_feature    10740..10753
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.77"
                     /tool="antismash"
     gene            10786..10974
                     /gene="pqqD"
                     /locus_tag="IEY95_RS39705"
                     /old_locus_tag="GCM10011579_080810"
     CDS             10786..10974
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03859.1"
                     /locus_tag="IEY95_RS39705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080810"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_308429389.1"
                     /sec_met_domain="PqqD_RRE (E-value: 6.6e-15, bitscore:
                     47.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.2e-11, bitscore: 36.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLLPERVVVLCGNAGSVVRLCDGSREVDEIVAELGERFPGAPVA
                     DEVPAFLTALRKEGWLQ"
     aSDomain        10789..10971
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IEY95_RS39705_PqqD_RRE.1"
                     /evalue="1.30E-15"
                     /identifier="RREFam006.1"
                     /label="IEY95_RS39705"
                     /locus_tag="IEY95_RS39705"
                     /protein_end="62"
                     /protein_start="1"
                     /score="47.9"
                     /tool="antismash"
                     /translation="LLLPERVVVLCGNAGSVVRLCDGSREVDEIVAELGERFPGAPVAD
                     EVPAFLTALRKEGWLQ"
     gene            10971..12074
                     /gene="pqqE"
                     /locus_tag="IEY95_RS39710"
                     /old_locus_tag="GCM10011579_080820"
     CDS             10971..12074
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645347.1"
                     /locus_tag="IEY95_RS39710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080820"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_189191100.1"
                     /sec_met_domain="PF04055 (E-value: 2.9e-24, bitscore: 79.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.6e-06, bitscore: 21.8,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.2e-09, bitscore:
                     30.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVAPPWALLAELTHGCPLRCAYCSNPVELISRSEELNTGQWVGV
                     LRQAADLGVVQTHLSGGEPLLRRDLADIVAAADTAGLYTQLVTSGVGLHERRLAELKDA
                     GLRCVQLSVQHADPITSELIAGARSFAAKERAAKLVRAAGLPLGLNVVLHRANIDALDD
                     LIALGLAWGADRVELANTQFYGWALRNRASLLPTREQVEHARQAVARRRESLGRAMELV
                     WVAADYLDGTAKPCMGGWGAVSLTVAPDGTVLPCPAAASLPGLDPPNAKDYQLAWIWRE
                     SHAFNAYRGEAWMQEPCRGCVLRTTDFGGCRCQAHALTGDAARTDPVCRHAPDHGLVRD
                     LVAAPYAADTARAAAPVAAPAYREGGT"
     gene            12071..13672
                     /locus_tag="IEY95_RS49655"
                     /old_locus_tag="GCM10011579_080830"
     CDS             12071..13672
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962384.1"
                     /locus_tag="IEY95_RS49655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080830"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_229703667.1"
                     /transl_table=11
                     /translation="MRRLRVLLMAVSLAAAGLAAVPASATPAVGLAGVPVSAAQAAIPA
                     SAAPAAVGYEAEYAAIGQGSVESDHTGFTGTGFVNYDNVAGSYVEFTVTAEEQATLPLA
                     FRFANGTTADRPMDITVNGVLVADNLSFPGNGSWTGWQTRTVDAALQQGGNTVRATAAS
                     ANGGPNLDSLSVGQPAVTTDWSVAMVESTMARYSPTTIGGWSYPVGLYLYGQYLTYQRT
                     HDPRSLSYIKNYVDRFVSSDGTIGQSFNNLDSMQAGRLLTILHHETGQDRYRIAAKKIR
                     DRLETYPRTSDGGFWHATSDSRAHQLWADGVYMVNPFLVEYGKEFNDSAYANNEAAKQL
                     YVYGSHLQVTNGLLKHAYDESRTASWSDPGTGLAPEHWCRAVGWYSMAIVNVLDAIPSS
                     HPRRAELLTILQKLAAGLEHYQDPNTGRWFQVVDKGDRSDNWTETSCSSMFTYALSRGA
                     QQGYIDAHYNDVAQRGYQGVLAKISLGSDGRTNLTDISIGTNVGDYAYYVARTRATNDF
                     HGLGAFLIMNEQLRAR"
     gene            13679..14482
                     /locus_tag="IEY95_RS39720"
                     /old_locus_tag="GCM10011579_080840"
     CDS             13679..14482
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385910.1"
                     /locus_tag="IEY95_RS39720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080840"
                     /product="heparin lyase I family protein"
                     /protein_id="WP_189191101.1"
                     /transl_table=11
                     /translation="MSSSPAPHDGPSRRKVIGAALGGAALAAGIPATAAAASWQLKWSP
                     SASGDGLGAFETIEDDRADSHPAGQPHIYPEGNNWRFTMHTVDRDTSTDRQRQEVTGLR
                     TSSAGYLKWQPGQTWRVTYSMYIPSSLKATTTFTHIMQMKQPGTGTSPIVVQSLRRVNG
                     AQTIELKLALSDTLIGRTSLDPLHDNWTDVDFQIKVGDGTSGSVRWILKSGGTTVIDKS
                     KSGVDTFLDDRVRPKWGIYRSLGDTSGSLQDCHLLLTNLRGYQLV"
     gene            14495..16435
                     /locus_tag="IEY95_RS39725"
                     /old_locus_tag="GCM10011579_080850"
     CDS             14495..16435
                     /GO_function="GO:0004650 - polygalacturonase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962386.1"
                     /locus_tag="IEY95_RS39725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080850"
                     /product="glycosyl hydrolase family 28 protein"
                     /protein_id="WP_229703668.1"
                     /transl_table=11
                     /translation="MRHPTRRSVAMALLGFLVVLGLSQPPAVARAQAPAVARTQALTAA
                     AAAVYNVRDYGARGDGSTNDTPAIQKAIDAANGAGGGTVRFPSPGSYKSKNTIHMKSNV
                     TLQVDTGAAIQGSSADTYDPPESNPYDQYQDYGHSHFHNAMIYGDRLTNIGFVGGGVID
                     GQGNLITGNPSSGEADKIISLTRCDGLRIGDGLTLRRGGHFAALINGCTNVASDHLNID
                     TASDRDGWNIISTTNVTVTNANIKANDDALVFKSDYALGAKLPNGHGRVSDSYLSAVCC
                     NALMFGSETCGDFTDYQFERIRIEGSNKSGLGMVSMDGAKISDVHYRDITMTNVHSPIM
                     QKIGTRKRCGNNPGVGSISDITYDNITATGSSPSFSPTLWGESSPNHISGVSFTNVNIT
                     VPGGNGTMSTAVPSNDPNNYNPNSIGTRPAYGWYLHNADHVSFTDSSVRFAADDGRPAV
                     IANSGSSVKFIRFTTQRGSASPYDMGFQTVSGYCVADSHNTSGGSLRISTSSSGQDCGT
                     APTRYEAENATYSAGSTVDSDHAGYSGTGFVNTDNTTGAYVEWAVNAAAAGTKTVALAY
                     ANGTTSDRPMDITVNGQVVASGVSFLPSADWTTWRTVSLAVPLTAGTNTLRATATTAAG
                     CPNLDYLDVPA"
     gene            16432..18615
                     /locus_tag="IEY95_RS39730"
                     /old_locus_tag="GCM10011579_080860"
     CDS             16432..18615
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174697.1"
                     /locus_tag="IEY95_RS39730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080860"
                     /product="discoidin domain-containing protein"
                     /protein_id="WP_229703669.1"
                     /transl_table=11
                     /translation="MNTLRRVSARLATAVVALLLGALLLPSPARADLQNPRQDFLRAST
                     GGLFLHWGERTAPQHTSCSGWESDVTGGGWSADYWVNEALKLHTQYLVLATFHSRLGYA
                     RPWPSAIPGSCATQRDFLGELVAAAKAKGLKVILYMTDDPQWHAEGGHEWLDSAAYSAY
                     KGHSVDLTTRDGFGEYSYDLFFEVMDRYPDLGGFWIDNDNAYWESHNLYAQIQQKRPSY
                     TLSNNNEDTPIMDMISNEQKTGMTPAYDYPQAVYTAQPRLTEADFKLPSSGAWWYDGTN
                     PSVDRALTLGRLVTNAGSSVKALMAETAMVNGRFPSNQESFNNFAASYLNPIWESLHGV
                     EGGGYMYGGLKPGFWNDGAHGVTTISKTDPDRHYVHVLTPPTTSTLRIRDNGYRIASVT
                     NLRTGAAVSWTQSGGVLTLNGLSGWDPYDTVFKVTTAGREGILPASSYTMSASASASGH
                     GAAAAADGSYLTYWDSNKTLPVDLTFDLGTAKKAQYIGLNQREDSVAYARSDTEQSARI
                     KDYKVYVSNDGSSWGSAVKTGQLASRRGIQGIDLTAVNARYVRLEVDSTWAASTDITRY
                     KRLRIDEAWIGTSYATPSTAAPPVRYEAENATYSAGSTVDSDHTGYSGTGFVNTANEVG
                     AYVSFGVSATGGGTADLTLRYSNGTTSDRPMDISVDGIVVAAAKSFPPNGSWDSWADVT
                     VGVPLAAGTHTVRATATTANGAPNLDHLEVREP"
     gene            18612..20354
                     /locus_tag="IEY95_RS39735"
                     /old_locus_tag="GCM10011579_080870"
     CDS             18612..20354
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF027814.5"
                     /locus_tag="IEY95_RS39735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080870"
                     /product="carbohydrate-binding protein"
                     /protein_id="WP_189191102.1"
                     /transl_table=11
                     /translation="MSCRFRRFRRGLLVALVGMLIAAAMPLMAAPPATASGNGQSVRPA
                     MGWSSWSFVRRWPTEDKIKAQADAMVSSGLVNHGFVYVNLDDFWQKCDANGFVVDSYGR
                     WSVDPAKFPSGIKALADYIHSKGLKFGFYVTPGIAKNAVLKNTPIEGTAYHAADIANTA
                     ALEKNYNCKNMYYIDYGKPGAQEFVDSWARQFASWGVDYLKIDGVGSADIPDVRAWDKA
                     LRATGRPINYALSNNLAIADAPTWRSLANSWRTQGDVECYCGSGSNGSGYPLTDWSHVS
                     ARFTSAANWQQYASPGGWNDLDSLEIGNGDQAGLTSDQRRSHFTLWAMAGAPLLLGTDL
                     THLDPVDTAMLTNDRLIGVDQDGYAAGRIVSSGVNQVWSKREDSGDYVVALFNTGTSGD
                     STVSVNWSQVGFTGSGDVTDLWSGSHKGTVTDTYSATLRPGETRLIRVTPLGAKTVRYQ
                     AENAGTSAGSTVDTNHIAYTGTGFVNTANEAGAYVEWTVDSATARTAPLTIRYANGTTT
                     GRPMDVSVNGAVVSAGRAFNDTGSWDIWADSTLTVPLNAGANTIRVTATTAGGAPNLDH
                     LDRG"
     gene            20585..21970
                     /locus_tag="IEY95_RS39740"
                     /old_locus_tag="GCM10011579_080880"
     CDS             20585..21970
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515889.1"
                     /locus_tag="IEY95_RS39740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_080880"
                     /product="carbohydrate-binding protein"
                     /protein_id="WP_229703670.1"
                     /transl_table=11
                     /translation="MHPAAPQRRLRVALAALCGLLLSLLLVPTQVAHAATDYQAEDATI
                     SQGTVATNHLNYTGTGFVDYTNVAGSYVQFTVDAAAAGQAGLQFRYANGSTTDRLMDIS
                     VNGTVVASNVSFPATANWDTWVTKTVNASLNAGTNTIRATATTANGGPNLDKLTLGSPS
                     GGGTPGMAVAPYEYFGWGNPQSPTSVMSATGVKWFTLAFILSDGSCNPAWDGSRPLTGG
                     DDQAKINSIRSAGGDVIVSFGGWSGNKLGEKCTSASVLAGAYQKVINAYGLKVIDIDIE
                     NTEWSSATVRQRVIDALKIVKANNAGLKTIITFGTTTNGPDSTGVDMINRGANSGLAND
                     IWCIMPFDFGGGTSNMGTLTTQAMEGLKGKVKAAYGYSDATTYAHIGLSSMNGKTDDAG
                     ELVRVSDFQTMLAYAQQHHIARLTYWSVNRDRACGSGSDGDSCSGVSQQPYDYLKVFVQ
                     YAG"
ORIGIN
        1 ttcaccccgc tgtacgccga ggcggcggcc tggctccggg agcggcggcc ggatcccgag
       61 ctgatcgtgg acgcgggcag tggcccggga gtgatctcct gtctcctcgc ggacaccttc
      121 ccgcaggcgc gggtcgtcgc cgtggacggc gcggaacccc tcctggaacg ggcccgcgcc
      181 cgtgcggacc ggctcggcgt cgccgaccgc ttcagcaccg tggaggccga actcgccgac
      241 ggtctcggct tcttggagta ccccgcagac ctgctgtggg ccagcaggtc gctgcaccat
      301 gtcggcgacc agcgcgccgc gctctccggt ttcgcgcgcg gtctcgcgcc cggcggcacc
      361 ctcgccctcc tggagggcgg cctgcccacg cgcttcctgc cgcgcgacat cggcatcggc
      421 cgccccggtc tgcagtcccg catcgatgcg gtccacgacg agtggttcac ccggatgcgg
      481 gccgagctgc ccggagccgt ggccgagacg gaggactggc ccgccctgct gaccgccgcg
      541 ggcctgcgcc acacggcgac ccgcacgttc ctcctcgact tccccgctcc gctgtcggac
      601 gaggcccgcg ctttcgtcgt caccagcctc acccagcgcc gggacggcct ggccgagggc
      661 ctcgacgcgg acgacctcgc caccctcgac cgactcctcg acccggacga caaggcgagc
      721 gtgcatcacc gaccggatgt gttcctgctg acagcgcaga ccgtgtacct cggggtgaag
      781 ccggagtagc cccctgccgc tcagcactcg cccgggtgcg cgtacacggt gacccgcgca
      841 ccccgcaccc gccgcgtgcc gcactcctcg aagtacaacg ccaggacccg ccgtttgacg
      901 atctcccgcg gagtccggtc cagtggctgc cccgcgggat cgcgtacggc gacgacgcgg
      961 ggcgtggcga gcaggcgcgc gcggatgacg agcgccggaa cctccgtgcc gtacaaggtg
     1021 tgcgaggcga cgggcccgcg ttccagggcc aggtcgcgca gcccgcgcac cgagccggga
     1081 tccggcagtg accacacgcg gcgccgcgcc ggcatgtaga gcacgccgtc accctgggca
     1141 ccggcctccg cgacggcccg ggccacggcg gtgacgtcgt cggtgcggct ctcgggcgtg
     1201 cgcaactgca gtgtgacggg gatcagcgcg agaaccgcgg ctcccgcgcc gaccagcgcc
     1261 accgtgcgga tccgtccggc ggcccgtatg agccggtcca gcgcggcgcc ggcgagaaga
     1321 gcggttccgg tctggccgta gagcacgtaa cggtccacgt acaggggttt caccagcgag
     1381 accagcagga gcaggagggc gggcagcacg aggagggcga gcccgagggc ggggagccgg
     1441 gggtgggatg cggcgctggt ggcgaaccgg ggtggtcggg gggtgagcgt gggggcctcc
     1501 gtcggtttcg ggcgtcggtt gtggggtgcg gagcggttcg cgggtacggc tggtcggttg
     1561 tggggtgcgg agcggttcgc gaccatcggc tgccgggacc tgcgtgcggc gccgagaccg
     1621 agtatccggg cgcaggccac ccccagcacg gccagtcccg cgaagccggc gtaggcaccc
     1681 gtaccaggac ccccgatcca ggacacctgg tccgactgac tcagactcaa cgcgccgagc
     1741 ggtgccatcg cgacgagcac cgtcaccgcc gcccgggccc agccccggcg tgcgccgcgc
     1801 ggcacggccg gcgcgtgcgc ggccagcgcc agtacggcga actcgtgcag cagacaggcc
     1861 gccaacagca ccgcgccgta cgcggcccag gcccggccgc cgccccggct tcgcacggcc
     1921 cgcgccagca gatacgtcgc ccacacgacc agagcgcaga cgacagcgta cgaacggccc
     1981 tcctgtccgt accgctggac ctgcggcagc accgcgaaga cggtcccggc cagcagaccg
     2041 gcgcggggcc cggcaagccg gtgcccgagg agggccaccg tcccggccgc cgcgaccgtg
     2101 gcgaggaccg acgggagccg caggaccagg agggggtcca gcccaccgga gaccatgaac
     2161 aggacatgca tgaacaggta gtacaggccg tgcacggcat cgacgccggc gagcgtcgac
     2221 cacaggtcgg gcagactgcg ccgggccatg tcgtacgtca ccgcctcgtc ccgccacatg
     2281 ctgccgccgc gccgcacgcc ccacagcccg agggcgagcg agagaacggc gggagcgaac
     2341 agcgccaccg gggtgcctgg ggcgcgcggt ggcaaccctg cgggggcgat cggtggtctg
     2401 gaagtctgtg tggtggcgat ggtcggctcc ggtgcgtggc ggaacctcgc ggtccccgct
     2461 gacggggccc cgaggacgta cgccaacgag tccagtcgcc ggtcgattga tgggcagccc
     2521 cgttgccccg caccaatcaa tccaggtggg agcgggtttc ggcggatcgg gtcgacgcga
     2581 acagggggag tcacgagtgg gacgccgtga gaagccggtg gacccggccg agggtgcggt
     2641 accgcgtttc gcgcacgagc tgcgcaagct gcgcgacgac gcgggcacac cgacctatcg
     2701 cgcgatggcg cgacatgccg gctattcggg gcccacactg tctgccgccg cggcgggcga
     2761 acggctgccc acgctgcccg tgctcctggc gtacgtcacc gcgtgcggag gcgacaccgc
     2821 cgcgtgggag cggcgctggc gcgagaccct cgcgacggaa gccggcacac gtgcaccgga
     2881 cgacgccgac agcccctacc cggggctcgc ccgcttcgag cccgccgacc gggaccggtt
     2941 ccacggccgc gacgacctga tcgcagaact cctcgaactc gtcgcccgcc gacggatatc
     3001 ggcggtcgtc ggcgcttccg gcagcgggaa gtcgtccctc ttgagggcgg gtctgattcc
     3061 cgcgttacgg gagaggaccg cggaggggcg caccgcgccg ggcaccccgg gggcacgcac
     3121 cccgtccgtc gccgcctccg gagcacctgt catcgatccg ccgggcccca gccccgcgcc
     3181 gctcgccgcc atccgcgtcc tcacccccgg cgcccatccc gcccggaccc acgacgcact
     3241 gttcagcccg cacgacgctc ccggcgacac cctcctcgtc atcgaccagt tcgaggaggt
     3301 gttcgccctc tgcaccgacc ccgccgaacg cgccctgttc atcgagcggt tgctcacggc
     3361 actggacccg gacagccggc tgcgggtgat catcggggtc cgggccgact tctacgggcg
     3421 gtgcgccgaa cacggccggc tggccgaggc gctgcgggac tccaccctgc tggtcgggcc
     3481 gatgaccgcg cagcggctgc gcgaggcggt cgtccggccg gccgccctgc ggcggctcgt
     3541 cgtcgaacgc gccctgaccg cacggatcgt ggcggacgtg gccgacgagc ccggcggtct
     3601 gccgctgatg gcccacgcgc tgcgcgagat ctggcggcgc cggaacggac ggacgctcac
     3661 tctcgccgcg tacgagtccg tcggcggtgt cgagggcgcc gtcgcccaca ccgcggagga
     3721 gctgtacgcc cgctgcacac cggccgaggc cgccgcggta cgggctctgc tgctgcgact
     3781 ggtgaacccg ggagacggtg ccgaggacac ccggcgtccc gtcgaccgcg ccgagctcgg
     3841 ctccgaggag acgaccgccg aggtcctcga acgcctggtc cgcgcccgcc tgttgaccgt
     3901 cgacggcgac accgtcgacc tcgcccacga ggctctgatc ggggcctggc cccggctgcg
     3961 cggctgggtg gacgaggacc gcgaacggct gcggctgcac cgccggctca ccgaggcggc
     4021 ccacacctgg cacgagctga accgggacac gggcgccctc tatcgaggtg tacgactgac
     4081 ggcggcgcag gaggaattcg gtgcccggca ggacgagttg agcccgctgg agcgcgactt
     4141 cctggccgcg agcatcgagg cgtacgagcg cggccgtcgg gtcgccgacc gtgcgacacg
     4201 acggctacgc ggcctgaccg tcggtctcgc cgtgctgctc tgcctggcgg tggtcgcggg
     4261 cgtggccgcc tggcggcaga gcggggtcaa cgcccggcag cgggacgagg cggaggcccg
     4321 ccgggtcgcc gcgttcgccg gcacgctccg ggcgaccgac ccgcgcacgg cgatgcgcct
     4381 cgcactggcg gcctggcgga cggccgacct gccggagacc cgcgaggcgg tgcggcaggc
     4441 cgcggcccag agcgaacagg acgccttcac ccagcccgca caggtccgcg cgctcaacgc
     4501 gccgtactgg ctcggcacgg acggccggat tctgacaact gtcgtacgtg acacggtcgt
     4561 tcagtgggac gtacgcagtc accggcaact gcgcgaggtg gcgctgcccg gtctgtcggg
     4621 gcggatcgtc gacgtcagcg ccgacgctcg cctgatcgcg taccacggcc ggtccggtgc
     4681 gacggtcaga gacctgacga acggagagaa ccaccgcatc gagtcgggga gttggaccga
     4741 cagcgacggc gcgttcgggt cgagcggtcg caccttcgtc gtacgacgcc tcgaccgtgc
     4801 ctcggacggc aggcgcgcca cgctcgaggt ctgggacata cgacgtcagc gggtcctctt
     4861 ccgatacgcg cagggcgatc cggacggacc gctgccgcta ctgagcccga acgaccggtt
     4921 cctcgcctgg tgcacccacg agggtgaaca gctgcgcatc tgggacgtcg tcgagcggcg
     4981 ccgggtcgcg accgagccac ccgcgcggac gcagcgcctc ctgtgccagt cggacgagcc
     5041 gaccttcacc cccgacaacc gcgctctggc cgcgggaacc gccgatggcg tcgtcacctg
     5101 ggacttccac gccgaccggg cgcgtcccct gctgccgatg cccggcgaag gcgcgctctc
     5161 cgtcgagttc gaccccaccg gcacctacgc gctcacctgg agcccgggca gcctggctct
     5221 gtggcgtacg gacctcccgg ctccggcgga cgacggtccg cgcgagccgc tcctgacgtt
     5281 ccccgtcgac accccggccg tcaccgccat ccggctcgac ccgagcgagg gagtgctgcg
     5341 cttccgcgaa ggctccgagg caggagtcgt acgcaccctt tccctgcgcg gtctcgtcgg
     5401 tccggcgtgg cggaagaagg cgcggaccgt cgccgcgttc gactccgccg ggaatccggc
     5461 cgaacccgcg gagcggcctg aggtgagggc cgttgccgcc gacggcacgg tacacaccgc
     5521 cgtcagcacc cgagacggga tccgcgtcac acggcagggc gcgcaacccg gctcccacgt
     5581 gatcggagag cggaccgaag gccccgcagc gatcgaccct gccggacgca cggtcgtgac
     5641 cttcgaggga gtcctgatcg acgtcgcgac gggcaggcgc agacagggat tcgaaggtga
     5701 ggatctcctg cccaccgtgt ccttcagtcc ggacggacgc ttcttggccg ccgctgacgt
     5761 ccagggtcgc ctcaccctgt gggacggggg cggacggcac cgcatcgccg tcctggcaac
     5821 cgccgactcc accgtcgagc gccctgccct ggctttctcg gccgacggct cgctggtggc
     5881 cgcgagccgg gccgacggtt cggtccgggt atgggagacg gcgtcaccgc ggctgcaggg
     5941 ggcggccctg ccggtgggcg acgggcccgt tctcgcggtt ggattcaccc cgggtgggcg
     6001 ggagttgcat atcgccacgg ctcatatgcc cctccgttcg gtgcagtcgg caccgggcgg
     6061 ggcggcagcc gaggtgtgcg cacgggcgga cggcggggcg actcgtgccg agtggagcag
     6121 gtatttgccc gacgtgccct atcggcgcac gtgttgagcc ttccgggcgc cgagttcccc
     6181 gggcttgact tcgagagtgc tccaagtgat gaactccagg cgttcaccgg aaatgtaggg
     6241 ggtaaccatg accgactcgc ccgtcgcact catcacgggt ggcggaagcg gcatcggcgc
     6301 cgcggtcgcg cgacgcctac tcgacgcggg tcaccgggtc accgtcaccg gacggggtga
     6361 gaagcgactg cacgccttcg ccgaggaact cggccgcccc gaggggctgt tgacgattgc
     6421 cgggaacgcg gcggagtacg accaggtgca ggcggcggtc gaggcgacgc tcaaggagtt
     6481 cgggcggctc gacaccgtcg tcgccagcgc cggcttcgcc acgcacgaca cggtcgccga
     6541 gggcgacccg gcgggctggt ccgagatggt gctgaccaat gtgctgggtc ccgcattgct
     6601 gatcagggcc tccatcgacg ccctgaagga gacccgcggc cggatcgtgc tggtcggcag
     6661 cgtcgcgggt cacatccaca cccccggcaa catctacggc gcgacgaagt gggccgtgac
     6721 aggcctcgcc gagaacaccc gccgtcaggt caccgaattc ggggtcggcg tgaccctgat
     6781 ctctcccggc cgcgtggaga ccccgttctg ggacagctac ggcagcctgc cgccgggtca
     6841 tctgctcacc gccgaccagc tcgccgagtc gatcgtctgg gcgatcgggc aaccggaagg
     6901 tgtggacgtg aacaccgtgg tcgtacgccc gatcggccag cctgtctgac ggttgccccg
     6961 tacggggcac ggggaactgc gcgatcggcc aaggtcggca cgcagttccc caacggcatt
     7021 cggcgcacgg tcagttgttc tgaaggaact tcttcgccag tgagtcaccc agcgacaccg
     7081 ccgcactgtg actctcgatc ggcgacacct gagagttctt gaacaggatg tacgtcacac
     7141 cggagtcggt cccgcccgtc tccgggtcgg ggtcgatgcc gagcgccttc gcggtggcgt
     7201 acgaggcctc gccaatgatc ttcgtgggcc cggtgtcacc gaccaccgcg tactcgacct
     7261 tgttgttgta gatgaccgcg accacgccgc cgcccttgat gccggagctc gtgtacttcc
     7321 agatgctgct ggtgctgggc accacgacgt atggcagcga gtcggcgcgc agcggcttgc
     7381 cgtcggactg gtggaaggcg gtgtcgtcct ggaaccaggg gtcggtgtcg ccgttgcact
     7441 tgctggtgac ctggccgtcg cagtcgatgt ccatgtcggc cttccagaac acggcgccgt
     7501 tcttgccgca gaccgggatg gtggccgacg tctcgtcgtc ggtcttgtac ttgccgttcg
     7561 atatctgcga acaggacgtc accttggcga gcaggtcggc cgcgctgacc gaaccctcct
     7621 gtgcggaacg ggggttgacg gtgccggagg cgttggccgg gagtaaggcg gtggcgagga
     7681 gcgcggcgcc ggaagccgcg gcgagggtca gtggtcgagt gcgcactgtg ggggaaccct
     7741 tctgttagga aactttcctt accggtgccg tacaacgtgg ccccctttgc gtgacctcgt
     7801 caagcccctg gtgtgaactc cggtgttccg agtcgattgc gaccattccc ttgcgggaga
     7861 agactggcta tatcgaacat tccgggtaaa cgcccggctt ctgggaggcg agtcgtcatg
     7921 ttcgtgcgga ctgtgtacgc gaccggcgat cccgtgacga tcgacacggc catcaagtcc
     7981 ttgaacacgc ggggccggga cctgctggag gatcgcccgg ggtatcgcgg atccagcatt
     8041 ttcgtggacc ggaagctcgg caaactcttc gtagtgagct ggtgggagtc cgaggaggcc
     8101 agacggaaca gcgaagaggt gctgcgcgag cggcgcgcgg cgctcctgga gccgttcgcg
     8161 gtgacgctgg cggtcgacaa ctacgaggcg gtggtcttcc atccggtccg gcagccgcag
     8221 gcgggaggcg gactgcggct cagcaggctg gagttcgacc ccgcggacgc ggatctgctt
     8281 gccgacacct tccgggcgac ggtggtcccc cagctcgaga acctcccggg gctggccagg
     8341 gcgtcactgg tcatcgaccg ggagcgcggc cgcggcctcg tcggcgtcgt gttcgtcgac
     8401 cgggagtccc tggtcgcgtc ccgcggcccc cagtcggcgg cccggcacga gggcgcggcc
     8461 aaagcgcacg tgaccgtgac tgggttggag gagttcgagg tcgtcttcac ggatgtgcgg
     8521 ggcggctgac gccttccacg ccggagccgg ccgacggtgg ggcgttcgac ggtcgtgttc
     8581 cgtacggggg ccggccgacg acggtcccgc tcccgtacgc gtccgccccg acgtgcggga
     8641 gaccatgcgg cggggcggac ggtcgcacgg ctgcgggcgt cagcccatgt cgaaggtcgc
     8701 cgggtccgga cccagacgac ggtcctcgct cagcgctgtg atcgccgcga tgtcctcggt
     8761 gtccagcgag aagtcgaaga cgttgatgtt ctccttgatc cgggacgggg tgacggactt
     8821 ggggatcacg atgttctcca gctggaggtg ccagcgcagc acgatctgcg ccggcgtgcg
     8881 gccgtgcttc tgggcgatgg cgacgatcgc cgggatctcc aggaggccct tgcccgagcc
     8941 gagcggcgac caggcctcgg tcgcgatgcc ccgctccgcg tggtactcgc gtgccgcgtg
     9001 ctgctggagg tgcgggtgca gttcgatctg gttgacggcc gggatgacgg acgtcgcgtc
     9061 gatcagcttc tccaggtgct ccggaaggaa gttggagacg ccgatggcct tggcgcggcc
     9121 gtccgcgtag agcctctcga aggccttgta cgtgtcgatg tacttgcccc gggacggcag
     9181 cggccagtgg atcagataca gatcgatgta ctccaggccg agcttctcca gcgacgcgtc
     9241 gaaggcgcgc agcgtcgagt cgtacccctg gtcgctgttc cagagcttgg tggtgacgaa
     9301 gagatccttg cgggcgatgc ccgaagcggt gatggccttg ccggtgccct tttcgttgcc
     9361 gtagatcgca gcggtatcga tgctgcggta cccggcctcc agtgcggtgg cgaccgcccg
     9421 ctccgcctcg tcgtccggca cctgccagac accgaagccc agctgcggca tctcgacgcc
     9481 gttgttcagg atgatcgggg ggaccttgct cacgagctct cgatccttca gtcgtcgggt
     9541 ggtatgccca tggtcaacga tcacgggccg taatgcattc ctgaccggtg gattcctcgt
     9601 ggattcatgg tgggggccgg atgtccagcc tcgccccaag aggaggttgg ccggaaatgg
     9661 atccgacctt ctcggtccgg accattgacc gggtcgcgtc accccgcaac tctgtatcac
     9721 gtcactgaac gctctcatga actcagtgca cgcatatgaa caccagcgtc tgtctgggcc
     9781 ccaccacacc tgtctgggct tcacaccccc cacccatcag gaaagcgggt acgcacacat
     9841 gaacgaacag ctggcttccg aggcctccgg tacacaatcg accattcggg aaacatcgga
     9901 ggaaagggtt tgggagaccc ccgggtatct cgtcgtcgag accgccctgg aggtcaccgc
     9961 gtacgccctc ggcgagcgct agaccatcgg tcgtcgaacc atgaccgtga caaccgtgcg
    10021 cgacgacggt gtcgcggccc cttggcgaac ccccgagttc accgagcggc tgcgcgccgt
    10081 cgccgaggag cgctaccacg accggcaccc cttcaacatc cgtatgcacc aaggggagtt
    10141 gacgcctgct gagctgcgcc gctggatcgc caaccgcttc cactaccagc gccatatccc
    10201 cgtcaaggac gccctgatcg tcgccaagct cgaccagccc gcgctgcgcc gtgcctggct
    10261 gcgcaggatc caggaccacg acggaacggc cgacggtgag ggcggcatcg aacgctggct
    10321 gcggctcggt gaggcggtcg gcctcgaccg tccgacactg tgggacgcga cccgggtgct
    10381 gcccggggtg cggctcgcgg tcgagggcta cgtcaacttc tgccgcctgc gccccgcgct
    10441 cgacgccgtc gccgcgtccc tgaccgagct gtcggcaccg tctctgatgc gcacccgcat
    10501 cgccgccttc gaacgccact acccgtggat cgaggccgag gggctcgcgt acttccgggc
    10561 ccgcatcggc cagggcggcc gcgacagcga ggaggccctc gcactcgtcc acgcctgggc
    10621 ccgcaccagg gagcagcagg agcgggcggt ggcggcactc gcgttcaagt gcgaggtgct
    10681 gtgggcgctg ctggacgccg tcgaccgggg cggcggctca tgacctggcg gcccgtcctg
    10741 tcccgctccg tgatgctccg tcacgatagc gtccggagcg ccgacttgct gctcctgccc
    10801 gagcgagtcg tcgtcctgtg cggcaacgcc ggcagtgtcg tccggctctg cgacggcagc
    10861 cgcgaggtgg acgagatcgt cgcggagctc ggcgaacggt tccccggcgc acccgtcgcc
    10921 gacgaagtcc ccgcattcct cacggcattg cgaaaggagg gctggctcca gtgaccgtgg
    10981 ctcccccctg ggcgctgctc gccgaactca cccacggctg cccgctgcgc tgcgcgtact
    11041 gctccaaccc cgtcgaactg atcagtcggt cagaagaact gaacactgga caatgggtcg
    11101 gggtactgcg tcaggccgcc gacctgggcg tcgtccaaac ccacctctcg ggcggcgaac
    11161 cgctcctcag acgtgatctc gccgacatcg tcgcggccgc cgacacggcc ggcctctaca
    11221 cccagctcgt caccagcgga gtcggcctgc acgaacgacg gctcgcggag ctcaaggacg
    11281 ccggactgcg ctgtgtccag ctctccgtgc agcacgccga tccgatcacc tccgaactca
    11341 tcgcgggcgc ccgttcgttc gctgccaagg agagggccgc gaagctggtt cgcgccgcag
    11401 ggctcccgct tggcctgaac gtcgtgctgc accgcgccaa catcgacgcc ctcgacgacc
    11461 tgatcgcgct cggacttgcc tggggcgccg accgggtcga gctggccaac acccagttct
    11521 acggctgggc gttgcgcaac cgtgcgtccc tgctcccgac ccgggagcag gtcgagcacg
    11581 cccgccaggc cgtagcccgc cgacgtgaaa gcctcggcag ggccatggag ttggtctggg
    11641 tcgccgccga ctatctcgac ggcaccgcga aaccgtgcat gggcggctgg ggcgccgtct
    11701 cgctcaccgt cgccccggac ggcacggtcc tcccgtgccc ggccgcggcc tcccttcccg
    11761 gcctcgaccc gccgaacgcg aaggactacc aactcgcctg gatctggcgc gagtcgcatg
    11821 ccttcaacgc ctaccgtggc gaggcctgga tgcaggagcc ctgccgcggc tgtgtcctgc
    11881 ggacgaccga cttcggcggc tgccgctgcc aggcgcacgc gctcaccggc gacgcggccc
    11941 gcaccgaccc ggtctgccgt cacgcgcccg accacggtct cgtccgcgac ctggtggcag
    12001 cgccgtacgc ggcggacaca gctcgtgcgg cggcccctgt cgcggcccct gcctatcgcg
    12061 aaggaggaac atgagacgtc tacgtgtgct gctgatggcg gtctcgctcg cggctgccgg
    12121 actggccgcg gtcccggcgt ccgccacgcc ggccgtcgga ctggccgggg tcccggtgtc
    12181 cgccgcccag gccgcgattc ccgcgtccgc cgccccggcc gccgtcggct acgaggccga
    12241 gtacgccgcg atcggacagg gcagcgtcga gtcggaccac accggcttca ccggcaccgg
    12301 gttcgtcaac tacgacaacg tggcgggcag ttacgtcgag ttcacggtca ccgcggagga
    12361 gcaggccacc ctgccgctcg ccttccgctt cgccaacggc acgaccgccg accgcccgat
    12421 ggacatcacc gtcaacggcg tcctggtggc cgacaacctg tccttccccg gcaacggctc
    12481 ctggaccggc tggcagacgc gtacggtcga cgccgcgctt cagcagggcg gcaacaccgt
    12541 ccgggccacc gccgccagcg cgaacggcgg ccccaacctc gactcgctgt ccgtgggaca
    12601 gcccgcggtc accaccgact ggtcggtcgc catggtcgag tcgacgatgg cgcgctactc
    12661 gccgaccacg ataggcggct ggtcgtaccc ggtcggcctg tacctctacg gccagtacct
    12721 cacgtaccag cgcacgcacg acccgcgctc tctctcgtac atcaagaact acgtcgaccg
    12781 cttcgtgtcg agcgacggca cgatcgggca gagcttcaac aacctcgaca gcatgcaggc
    12841 cggacggctg ctgacgatcc tgcaccatga gaccggccag gaccgctacc gcatcgcggc
    12901 caagaagatc cgcgaccgcc tcgagaccta tccccgcacc tcggacggcg gcttctggca
    12961 cgcgacctcg gacagccggg cccaccaact gtgggcggac ggcgtctaca tggtcaatcc
    13021 gttccttgtg gagtacggca aggagttcaa cgactcggca tacgcgaaca acgaggcggc
    13081 caagcagctg tacgtctacg gcagccatct ccaggtcacg aacggcctgt tgaagcacgc
    13141 ctacgacgag tcgcgcacgg cgagctggtc cgacccgggg accggtctcg cccccgagca
    13201 ctggtgccgg gcggtcggct ggtactccat ggccatcgtc aacgtgctgg acgcgatccc
    13261 cagttcgcac ccgcgccgcg ccgagctcct gaccatcctg cagaagctgg ccgcgggcct
    13321 ggagcactac caggacccga acaccggccg ctggttccag gtcgtcgaca agggcgaccg
    13381 cagcgacaac tggaccgaga cgtcctgctc cagcatgttc acctacgccc tctcgcgcgg
    13441 cgcccagcag ggctacatcg acgcgcacta caacgacgtc gctcaacgcg gctaccaggg
    13501 cgtcctggcg aagatctcac tcggctccga cggccggacg aacctcacgg acatctccat
    13561 cggcacgaac gtcggcgact acgcctacta cgtggcccgc accagagcga ccaacgactt
    13621 tcacggtctc ggcgcctttc tgatcatgaa cgaacaactc agggcgaggt gacggaagat
    13681 gagctcatcc cccgcgccgc acgacgggcc gtcccgccgg aaggtgatcg gcgccgcact
    13741 cggcggcgcc gcgctcgccg cggggatccc ggccaccgcc gccgcggcga gctggcagct
    13801 gaagtggtcc ccgtccgcga gcggcgacgg gctcggtgcc ttcgagacga tcgaggacga
    13861 ccgtgccgac tcgcaccccg ccgggcagcc gcacatctac ccggagggga acaactggcg
    13921 gttcaccatg cacacggtgg accgcgacac cagcaccgac cgacagcgcc aggaggtcac
    13981 cgggctgcgc accagcagcg ccggctatct gaagtggcag ccgggccaga cctggcgggt
    14041 gacgtactcg atgtacattc cgagctcgct gaaggcgacc acgaccttca cccacatcat
    14101 gcagatgaag cagccgggga ccgggacttc gccgatcgtc gtgcaatcgc tgcggcgcgt
    14161 gaacggcgcc cagaccatcg agttgaaact cgccctctcc gacaccctga tcggccgcac
    14221 cagtctggac ccgctgcacg acaactggac ggacgtcgac ttccagatca aggtcggcga
    14281 cggcacgtcg ggatccgtgc gctggatcct caagagcggc ggcacgaccg tgatcgacaa
    14341 gtcgaagtcc ggtgtggaca ccttcctcga cgaccgcgtg cggcccaagt ggggtatcta
    14401 ccgctccctc ggcgacacgt cgggttcgct gcaggactgc catctgctcc tcaccaacct
    14461 ccgtggctac caactggtct gagacgaggc cgacatgaga catccaaccc gcagatccgt
    14521 cgccatggcc ctgttgggct tccttgtcgt gctgggcctc tcccagcccc cggccgtcgc
    14581 ccgcgcccag gcacccgccg tcgcccgcac ccaggcactc accgccgccg cggccgctgt
    14641 ctacaacgtg cgcgactacg gcgcgagggg cgacggctcc accaatgaca cgcccgccat
    14701 ccagaaggcc atcgacgccg cgaacggtgc gggcggcgga accgtgcggt tcccctcgcc
    14761 cggcagctac aagtccaaga acacgatcca catgaagagc aacgtgacac tccaggtcga
    14821 cacgggcgcc gcgatccagg gctccagcgc ggacacgtac gacccgcccg agtccaaccc
    14881 gtacgaccag taccaggact acgggcacag ccacttccac aacgcgatga tctacggcga
    14941 ccggctgacc aacatcggct tcgtgggcgg cggcgtcatc gacggccagg gcaacctgat
    15001 caccggcaac ccgtcctccg gtgaggccga caagatcatc tccctgaccc ggtgcgacgg
    15061 cctgcggatc ggcgacggtc tgaccctgcg ccgtggcggc catttcgcag cgctcatcaa
    15121 cggctgtacg aacgtcgcct cggaccatct gaacatcgac acggcgagcg accgcgacgg
    15181 ctggaacatc atcagcacca ccaacgtcac ggtgacgaac gcgaacatca aggccaacga
    15241 cgacgcgctg gtcttcaaga gcgactacgc gctgggcgcc aagctgccca acggccacgg
    15301 ccgggtcagc gactcgtatc tctccgcggt gtgctgcaac gcgctgatgt tcggttccga
    15361 gacgtgcggc gacttcacgg actaccagtt cgagcgcatc aggatcgagg gctccaacaa
    15421 gtccgggctc ggcatggtct ccatggacgg cgccaagatc tccgacgtcc actaccgcga
    15481 catcaccatg acgaacgtcc actcgccgat catgcagaag atcggtaccc gtaaacgctg
    15541 cggcaacaac ccgggcgtcg gttcgatcag cgacatcacc tacgacaaca tcacggccac
    15601 cggttccagc ccctctttca gtccgaccct atggggcgag tcgagcccga accacatcag
    15661 cggcgtcagc ttcaccaacg tcaacatcac cgtccccggc ggcaacggca ccatgtccac
    15721 cgcggtgccg agcaacgacc cgaacaacta caacccgaac agcatcggca cccggcccgc
    15781 gtacggctgg tacctgcaca acgccgacca cgtcagcttc accgacagtt cggtgcggtt
    15841 cgccgccgac gacgggcggc ccgcggtcat cgccaacagc ggcagctcgg tgaagttcat
    15901 ccggttcacc acccagcgcg gcagcgcgag cccgtacgac atgggcttcc agaccgtgag
    15961 cggatactgc gtcgccgaca gccacaacac gtccggcggc tccctgcgga tctcgacgtc
    16021 gagctccggc caggactgcg gcacggcccc cacccggtac gaggcggaga acgccacgta
    16081 ctcggcgggc agcaccgtcg acagcgacca cgcgggctac tccggcaccg gcttcgtcaa
    16141 cacggacaac accaccggcg cttatgtgga gtgggcggtg aacgcggcgg cggccggcac
    16201 gaagaccgtc gccctcgcgt acgcgaacgg caccacctcc gaccggccca tggacatcac
    16261 ggtgaacggg caggtcgtcg cctccggcgt ctccttcctg cccagcgccg actggacgac
    16321 ctggcgcacg gtctcccttg ccgtcccgct caccgcggga accaacaccc tccgggcgac
    16381 ggcgaccacg gcggccggct gccccaacct cgactacctg gacgtcccgg catgaacact
    16441 ctcagacgtg tgagcgctcg tctggcgacg gccgtggtgg cgctcctcct cggagcgctg
    16501 ctgctgccct ccccggcacg agcggacctg cagaacccgc gccaggactt cctgcgcgcc
    16561 tcgaccggcg gactcttcct gcactggggc gagcggaccg ccccgcagca caccagctgc
    16621 agtggctggg agtccgacgt cacgggcggc ggctggagcg cggactactg ggtgaacgaa
    16681 gccctcaagc tgcacaccca gtacctggtc ctcgccactt tccacagccg tctcgggtac
    16741 gcgcgcccct ggccctcggc gatccccggc agctgcgcca cccagcgcga cttcctcggt
    16801 gagctggtcg cggcggccaa ggcgaagggc ctcaaggtca tcctctacat gaccgacgac
    16861 ccgcagtggc acgccgaagg cggtcacgag tggctggact cggccgccta ctccgcctac
    16921 aagggccact cggtcgacct gaccacccgc gacggtttcg gcgagtactc ctacgacctc
    16981 ttcttcgagg tcatggaccg ctacccggac ctcggcggct tctggatcga caacgacaac
    17041 gcgtactggg agagccacaa cctctacgcg cagatccagc agaagcggcc gagctacacg
    17101 ctcagcaaca acaacgaaga cacaccgatc atggacatga tcagcaatga gcagaagacg
    17161 ggaatgacgc cggcctacga ctatccgcag gccgtctaca cggcccaacc ccgcctgacc
    17221 gaggccgact tcaagctgcc ctccagtggc gcgtggtggt acgacggcac gaatccgagc
    17281 gtcgaccggg ccctcactct cggccggctc gtcaccaacg cgggctcgtc ggtgaaggcg
    17341 ctgatggccg agacggcgat ggtcaacggc agattcccgt ccaaccagga gtccttcaac
    17401 aacttcgcgg ccagttatct gaaccccatc tgggagtcgc tgcacggagt cgagggcggc
    17461 ggctacatgt acggcggcct caagcccggc ttctggaacg acggcgcgca cggcgtgacg
    17521 acgatcagca agaccgaccc cgaccggcac tacgtccacg tcctgacgcc gccgaccacc
    17581 agcaccctgc gcatccgcga caacggctac cgcatcgcgt ccgtcaccaa cttgcgcacc
    17641 ggggcggccg tttcctggac ccagtcgggc ggagtcctca cactgaacgg gctcagcggc
    17701 tgggacccgt acgacaccgt cttcaaggtg acgacggcgg gccgcgaggg catcctgccc
    17761 gcttcctcct acacgatgag cgcgagcgcg tcggcgagcg gtcacggggc cgcggccgcg
    17821 gcggacggca gttatctgac gtactgggac agcaacaaga cgctgccggt cgacctcacc
    17881 ttcgacctcg gcacggccaa gaaggcgcag tacatcggcc tcaaccagcg tgaggactcc
    17941 gtcgcctacg cgcgctccga caccgagcag tccgcccgca tcaaggacta caaggtgtac
    18001 gtcagcaacg acggctccag ctggggaagt gccgtcaaga cggggcaact ggcgagccgc
    18061 cgcggcatcc agggcatcga cctgaccgcc gtcaacgccc gctacgtacg cctcgaagtg
    18121 gactcgacct gggccgcctc caccgacatc acccgctaca agcggctgcg gatcgacgag
    18181 gcgtggatcg gtacgtcgta cgcgaccccg agcaccgcgg cgccgcccgt gcgctacgag
    18241 gcggagaacg ccacctactc ggcgggcagc accgtggact cagaccacac cgggtactcc
    18301 ggcacggggt tcgtgaacac cgccaacgag gtgggcgcgt atgtgtcgtt cggcgtcagt
    18361 gccaccggcg gcggcacggc cgatctgacg ctccgttact ccaacggcac gacgtccgac
    18421 cgtccgatgg acatctccgt cgacggcatc gtggtcgccg ccgccaagtc cttccctccg
    18481 aacggcagtt gggacagctg ggccgatgtc acggtcggcg tcccgctcgc ggccggcacc
    18541 cacaccgtcc gtgccaccgc gaccaccgcg aacggggcgc ccaatctcga ccatctggag
    18601 gtgagggagc catgagctgc cggttccggc gattcaggag aggactcctc gttgccctgg
    18661 tgggcatgct gatcgccgcg gcgatgcccc tgatggccgc cccgcccgcc accgcctcgg
    18721 gcaacggcca gtccgtgcgg cccgcgatgg ggtggagcag ctggagcttc gtgcggcgct
    18781 ggcccaccga ggacaagatc aaggcgcagg ccgacgcgat ggtcagcagc ggcctcgtga
    18841 accacggctt cgtgtacgtc aatctcgacg acttctggca gaagtgcgac gccaacggat
    18901 tcgtcgtgga ctcctacggc cgctggagtg tcgacccggc gaaattcccg tccggcatca
    18961 aggcgctcgc cgactacatc cactccaaag gactcaaatt cggcttctac gtcactccgg
    19021 gcatcgccaa gaacgccgta ctgaagaaca cgccgatcga gggcacggcg taccacgcgg
    19081 cggacatcgc gaacaccgcg gccctggaga agaactacaa ctgcaagaac atgtactaca
    19141 tcgactacgg caagccgggc gcgcaggaat ttgtggattc ctgggcgcgg cagttcgcct
    19201 cctggggagt cgactacctc aagatcgacg gggtcggaag cgcggacatc cccgacgtac
    19261 gggcctggga caaggcgctg cgggccacgg gccggccgat caactacgcc ctgtccaaca
    19321 acctcgcgat cgccgacgcg cccacctggc gctcactggc caacagctgg cgcacccagg
    19381 gcgacgtcga gtgctactgc ggctccggtt cgaacggcag cggctatccg ctcaccgact
    19441 ggtcgcacgt ctcggcccgc ttcacctcgg cggccaactg gcagcagtac gcgagtcccg
    19501 gcggctggaa cgacctggac tcgctggaga tcggcaacgg cgaccaggcc ggcctcacct
    19561 ccgaccagcg ccgctcccac ttcaccctct gggcgatggc gggcgcccca ctgctgctcg
    19621 gtaccgacct gacgcacctc gacccggtcg acacggcgat gctcaccaac gaccgtctca
    19681 tcggcgtcga ccaggacgga tacgccgcgg ggcgcatcgt ctccagcggc gtcaaccagg
    19741 tctggagcaa gcgcgaggac agcggtgact acgtggtggc gctcttcaac acgggtacgt
    19801 cgggcgactc cacggtgagc gtgaactggt cgcaggtcgg gttcacgggc tcgggcgatg
    19861 tgacggacct gtggtcgggc tcccacaagg gcacggtcac ggacacctac agcgcgacgc
    19921 tgcgtccggg ggagacacgg ctcatcaggg tcaccccgct cggtgccaag accgtccggt
    19981 accaggcgga gaacgcgggc acctcggcgg gctccaccgt cgacaccaac cacatcgcgt
    20041 acaccggaac cggctttgtg aacaccgcca acgaggccgg cgcgtacgtc gagtggaccg
    20101 tcgactccgc caccgcccgc accgcacccc tgaccatccg gtacgccaac ggcacgacca
    20161 cgggccgccc gatggacgtc agcgtcaacg gcgccgtcgt ctccgcgggc cgtgccttca
    20221 acgacaccgg cagctgggac atctgggccg actcgaccct caccgtgccg ctgaacgccg
    20281 gggccaacac gattcgggtg accgccacca cggccggtgg cgcgccgaat ctcgatcatc
    20341 tcgaccgggg ctgagaggag gcgcaaaagg gtcatttccc ggggggacct cacggggggc
    20401 gggacgttcc cgtcgcccct tgagggctgc ccgcaaacag gaagtgcctg tgctttatgt
    20461 gcacggtgaa ctctcccgat gccattgaca atccggcgtt ccgacgctgc tatgcagtga
    20521 tggttaggaa cgtttcctaa catcctttca gtgctcctca ttccgtcccg ggaggacgat
    20581 ccacgtgcac cctgccgcac cccaacgccg actacgcgta gccctggccg cgctctgcgg
    20641 gctgctgttg tccttgttgc tcgttcccac gcaagtcgcc catgccgcga ccgactacca
    20701 ggccgaggac gccacgatct cgcagggcac ggtggcgacg aaccacctga actacacggg
    20761 cacgggcttc gtcgactaca ccaacgtcgc tggttcgtat gtgcagttca cggtggacgc
    20821 ggcggctgcc gggcaggccg ggctgcagtt ccggtatgcc aacgggtcga ccactgaccg
    20881 gctgatggac atctccgtca acggcacggt ggtcgcctcg aacgtgtcgt tcccggccac
    20941 cgcgaactgg gacacctggg tcaccaagac cgtcaacgcc tcgctgaacg cgggcaccaa
    21001 caccatccgg gcgaccgcga ccaccgccaa cggtggcccc aacctcgaca agctcaccct
    21061 cggcagcccc tcgggcggcg gcaccccggg gatggccgtc gcgccctacg agtacttcgg
    21121 ctggggcaac ccgcagagcc ccacctccgt gatgtcggcg accggcgtca agtggttcac
    21181 gctggccttc atcctctccg acgggtcctg caaccccgca tgggacggct cgcgcccgct
    21241 gaccggcggt gacgaccagg cgaagatcaa ctccatccgg tcggccggcg gtgacgtgat
    21301 cgtctccttc ggcgggtgga gcggcaacaa gctcggcgag aaatgtacca gcgcctcagt
    21361 cctcgccggt gcgtaccaga aggtcatcaa cgcctatggc ctgaaggtca tcgacatcga
    21421 catcgagaac accgagtggt ccagcgcgac ggtccgtcag cgggtgatcg acgcactgaa
    21481 gatcgtcaag gcgaacaacg cgggcctcaa gaccatcatc accttcggta cgaccaccaa
    21541 cggcccggac tccaccggcg tcgacatgat caaccgtggt gccaactccg gtctggcgaa
    21601 cgacatctgg tgcatcatgc ccttcgactt cggcggcggc accagcaaca tgggcacgct
    21661 gacgacccag gccatggaag gcctcaaggg caaggtcaag gccgcctacg gctacagcga
    21721 cgcgaccacc tacgcgcaca tcgggctctc ctcgatgaac ggcaagaccg acgacgcggg
    21781 cgagctggtc cgtgtctccg acttccagac gatgctcgcc tacgcgcagc agcaccacat
    21841 cgcgcgcctc acctactggt ccgtgaaccg cgaccgggcc tgcggctccg gctctgacgg
    21901 ggactcctgc agcggtgtgt cacagcagcc gtacgactac ctcaaggtct tcgtccagta
    21961 cgcgggttga ggagaacagc cgtgaagaga acagccatga acagaacgcg tcgcagaacc
    22021 atcctgtcgt ggtccacctc cctggctctc gcactgcccc tgctcggctg ggcg
//
