LOCUS       NZ_BMMM01000019        10210 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces albiflavescens strain CGMCC 4.7111 sequence19, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMM01000019
VERSION     NZ_BMMM01000019.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces albiflavescens
  ORGANISM  Streptomyces albiflavescens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 200641)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 100X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645835.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:24:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,828
            CDSs (total)                      :: 9,745
            Genes (coding)                    :: 9,386
            CDSs (with protein)               :: 9,386
            Genes (RNA)                       :: 83
            rRNAs                             :: 1, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 102 of 359
            Pseudo Genes (incomplete)         :: 321 of 359
            Pseudo Genes (internal stop)      :: 17 of 359
            Pseudo Genes (multiple problems)  :: 80 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:54:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 21781
            Orig. end                         :: 31991
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMM01000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10210
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10210
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10210
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5210](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5210
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(382..397)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            493..2244
                     /gene="oxc"
                     /locus_tag="IEY95_RS38520"
                     /old_locus_tag="GCM10011579_078370"
     CDS             493..2244
                     /EC_number="4.1.1.8"
                     /GO_function="GO:0008949 - oxalyl-CoA decarboxylase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0033611 - oxalate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="oxc"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123841.1"
                     /locus_tag="IEY95_RS38520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_078370"
                     /product="oxalyl-CoA decarboxylase"
                     /protein_id="WP_189190877.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.8e-45, bitscore:
                     148.0, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.1e-27, bitscore:
                     87.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPSTMETAAAADVPTELTDGYHLVVDALKMNDVDTIYGVVGIP
                     ITDLARLAQAQGIRYIGFRHESNAGHAAAAAGYLTKKPGVALTVSAPGFLNGLVALANA
                     TTNCFPMVQISGSSERHLVDLKQGDYEEMDQLAAAQPFVKAAYRVSRVEDIGRGIARAL
                     RTAISGRPGGVYLDIPAAVLGSIMDKEAGAKTLSRLVDPSPRQLPAPEAVDRAIELLAG
                     AERPLVVLGKGAAYAQADAKIREFIESTGIPYVPMSMAKGLLPDDHPQSAATARSLALK
                     KADVVMLVGARLNWLLNHGEAPQWNPDAKFIQVDIEPKEMDSNQPIAAPLVGDIESVLD
                     TLAERTKPGQIAAPAAWREELGARSAQNVAKMAERLKADPHPMQFMGALKAVRDVIHAR
                     PETYLVNEGANALDIARNVIDMHVPRHRLDSGTWGVMGIGMGYAIAAAVESGAPVVAVE
                     GDSAFGFSGMELETICRYKLPVVTIIMNNGGVYRGDDVNPLDDAPSPTTLMLAARHDLM
                     IEAFGGKGYRATTPAEVTAALTEALASGGPALIDCVIDPSAGTESGHISHLNPKGITVG
                     NITPAKK"
     gene            2334..3590
                     /gene="frc"
                     /locus_tag="IEY95_RS38525"
                     /old_locus_tag="GCM10011579_078380"
     CDS             2334..3590
                     /EC_number="2.8.3.16"
                     /GO_function="GO:0033608 - formyl-CoA transferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0033611 - oxalate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="frc"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123842.1"
                     /locus_tag="IEY95_RS38525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_078380"
                     /product="formyl-CoA transferase"
                     /protein_id="WP_189190878.1"
                     /transl_table=11
                     /translation="MSEKPLAGIKVIDFTGVQAGPACTQMLAWFGADVIKVERPQGGDV
                     TRNQLRDIPDLDALYFTMLNSNKRSLAINTKTPEGKEVMEKLIREADILVENFAPGAMD
                     RMGLGWDHIHELNPRLIFGSVKGFNDASSWSDLKVYENVAQAAGGAASTTGFWDGPPTI
                     SGSALGDSNTGMHLLIGLLTAIIQRNATGLGQKVSVSMQDAVLNLTRVKLRDQQRLEKV
                     GYLEEYPQYPHGEFGDAVPRGGNAGGGGQPGWILKCKGWETDPNAYIYFTVQEQNWKRT
                     AEAIGHPEWVDDPDYTTARARQPRIMEIFGEIEKWLADKTKYEAVDILRKWEVPCAPVL
                     SMKELAEDPDMRKSGTIVEVEQKERGTYLTVGSPIKFSGFKPDIQGAPLLGEHTDEVLA
                     DLGYDADDIRKLHEGQVVA"
     gene            4120..4371
                     /locus_tag="IEY95_RS38530"
                     /old_locus_tag="GCM10011579_078390"
     CDS             4120..4371
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY95_RS38530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011579_078390"
                     /product="hypothetical protein"
                     /protein_id="WP_189190879.1"
                     /transl_table=11
                     /translation="MVIALVPWLLLPVAWAALPWLPPNRTFGCFVAAVQLMLSVAALSV
                     GMPAENLPAWFLIPGLVSSVARLASVSSLRARTRRGQA"
     gene            <4498..4626
                     /locus_tag="IEY95_RS49630"
                     /old_locus_tag="GCM10011579_078400"
                     /pseudo=""
     CDS             <4498..4626
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451014.1"
                     /locus_tag="IEY95_RS49630"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_078400"
                     /product="DUF2000 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="HDRIDRAAVQAVPTEELDLMGLAVCRPRNAVDKVLKGARMHM"
     misc_feature    4729..4744
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.25"
                     /tool="antismash"
     misc_feature    4850..4863
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.09"
                     /tool="antismash"
     misc_feature    complement(4971..4986)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.84"
                     /tool="antismash"
     gene            5001..5210
                     /locus_tag="IEY95_RS38540"
                     /old_locus_tag="GCM10011579_078410"
     CDS             5001..5210
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009311933.1"
                     /locus_tag="IEY95_RS38540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_078410"
                     /product="hypothetical protein"
                     /protein_id="WP_189190881.1"
                     /sec_met_domain="strepbact (E-value: 2.6e-15, bitscore:
                     50.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSAPQVQTLEISDAELDTVSGGLSPQVGIAAGPTAISSSDLVAQ
                     FGAVKDEIQDTVGQYHQAGVAVSF"
     gene            5967..6503
                     /locus_tag="IEY95_RS38545"
                     /old_locus_tag="GCM10011579_078420"
     CDS             5967..6503
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY95_RS38545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011579_078420"
                     /product="hypothetical protein"
                     /protein_id="WP_189190882.1"
                     /transl_table=11
                     /translation="MAGAARDGLIRVVPFERMSALMMAAGAVLSEGVLLALIATANRLE
                     TLLVGTVVVILMSLAMLPLSFRLPARRRHQYEHAVRIDSVAVPLEGQDASRRQSLWRTA
                     VAVGVLACWMMLLGLTFHEVMPPVMLVPLAVLLWARSRATAHWERVNGAALWQGVPGLL
                     GSRGPVFRVPAAGGI"
     gene            6661..6879
                     /locus_tag="IEY95_RS38550"
     CDS             6661..6879
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013855.5"
                     /locus_tag="IEY95_RS38550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_189191007.1"
                     /transl_table=11
                     /translation="MRPPSCWSGEAPTIREIGRSVGLSSPSSVAYRPEQMEQLGVIRRT
                     ARRGWGRGIALGWRRAPRGRSHLDSNV"
     gene            6876..7214
                     /locus_tag="IEY95_RS38555"
                     /old_locus_tag="GCM10011579_078430"
     CDS             6876..7214
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674333.1"
                     /locus_tag="IEY95_RS38555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_078430"
                     /product="DUF6233 domain-containing protein"
                     /protein_id="WP_189190883.1"
                     /transl_table=11
                     /translation="MNDPLPLTRLDLLRFLERVQEQDLTRMRRWIEAEKQREAEGQRGF
                     DARPPAPDWLIEQGLSGRDPVYVHVGGCWNAGKRSRGVERDQALRALVDGVPACTHCRP
                     GSELGYLE"
     gene            7261..7479
                     /locus_tag="IEY95_RS38560"
                     /old_locus_tag="GCM10011579_078440"
     CDS             7261..7479
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608014.1"
                     /locus_tag="IEY95_RS38560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_078440"
                     /product="hypothetical protein"
                     /protein_id="WP_189190884.1"
                     /transl_table=11
                     /translation="MPESVPVVVHPPQPDGGRRVTIRGEPVGTAYHVLDVVEFLRREGL
                     PEADTTIDDPELIEWRGGGPKVWTAPG"
     gene            complement(<7695..7898)
                     /locus_tag="IEY95_RS49635"
                     /pseudo=""
     CDS             complement(<7695..7898)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029009.1"
                     /locus_tag="IEY95_RS49635"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPPGITYSAVLDVSRQTAHFLARLLQQHRERLGTRKGTRALSPFK
                     HPVLVLRWFVDGTRRAQLAPAGG"
     misc_feature    8243..8257
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.75"
                     /tool="antismash"
     misc_feature    complement(8319..8334)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.61"
                     /tool="antismash"
     misc_feature    9084..9097
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.51"
                     /tool="antismash"
     misc_feature    9564..9577
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    9790..9803
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.08"
                     /tool="antismash"
     misc_feature    complement(9814..9827)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.65"
                     /tool="antismash"
ORIGIN
        1 gcgtccccgc ggtgcagccc cgtgccgccg agccgggcgg ccacgtcgtc ggccagcgcg
       61 gcgagggcgc ggtacgacag gtgcacccgg tcgccggtga cgacaagcgc cctggcatgc
      121 gggcgctcgc gaacgtgccg atcgaggaga tcgacgagac ccgtgaccgc cgggggccgg
      181 taccggtccg cgtcgtgcac ggatgccgcc gccggaacgg ccatgactcc acctcctcgc
      241 gcccagcctg atgaaagcag tcctctgcga gcctgcggcg gcgtgcggag cgcgtccaat
      301 acccactggt gaacggccga tagcaggcgt ctatcaaggg agctgcgagg cgacgtcgca
      361 cccctccacc agccatcgat agatgctgtt tatcagttgg tcgtcgatgg gtcttggacg
      421 cgggcaggcg cgcttacgaa ggtgagagca gtagccgcac aggcaggacc tgcccaagga
      481 ggacctcgga ccatgaccgc cccctcgaca atggagaccg cggcagcagc cgacgttccg
      541 accgagctca ccgacgggta ccacctggtc gtcgacgcgc tcaagatgaa cgacgtcgac
      601 accatctacg gggtggtcgg catcccgatc accgacctgg cccgcctcgc gcaggcgcag
      661 ggcatccgct acatcggctt ccgtcatgag agcaacgccg gacacgcggc cgcggccgcc
      721 ggctacctca cgaagaagcc gggcgtggcg ctgacggtgt cggcaccggg cttcctcaac
      781 gggcttgtcg cgctggcgaa cgcgaccacc aactgcttcc cgatggtcca gatctccggc
      841 tccagcgagc gccacctcgt cgacctcaaa cagggcgact acgaggagat ggaccagctc
      901 gccgccgccc agccgttcgt caaggccgcg taccgggtga gccgggtcga ggacatcggc
      961 cggggcatcg cccgcgcact gcgcaccgcg atctccgggc gccccggcgg ggtctacctc
     1021 gacatccccg ccgcggtgct cggctccatc atggacaagg aggcgggcgc caagacgctc
     1081 agccgtctcg tcgacccctc gccccgccaa ctgcccgcac ccgaggccgt ggaccgcgcg
     1141 atcgagctcc tggcaggcgc cgagcggccg ttggtggtgc tcggcaaggg cgccgcgtac
     1201 gcgcaggccg acgccaagat ccgtgagttc atcgagtcca ccggcatccc gtacgtaccg
     1261 atgtcgatgg cgaagggcct gctgcccgac gaccacccgc agtcggcggc caccgcccgt
     1321 tcgctggcgc tgaagaaggc cgacgtcgtc atgctcgtcg gcgcccgcct caactggctg
     1381 ctgaaccacg gcgaggcacc ccagtggaac cccgacgcca agttcatcca ggtggacatc
     1441 gagcccaagg agatggacag caaccagccc atcgccgccc cgctcgtcgg tgacatcgag
     1501 tcggtgctcg acacgctcgc cgagcggacc aagccgggcc agatcgcggc tcccgccgcc
     1561 tggcgggagg agctgggggc acgctcggcg cagaacgtcg ccaagatggc ggagcgcctc
     1621 aaggccgacc cgcaccccat gcagttcatg ggcgccctga aggccgtacg cgatgtcatc
     1681 cacgcacgcc ccgagacata cctcgtcaac gagggcgcca acgccctgga catcgcgcgc
     1741 aacgtcatcg acatgcacgt accgcgccac cgcctcgaca gcggcacctg gggtgtcatg
     1801 ggcatcggca tgggctacgc gatcgccgcc gccgtcgaga gcggcgcacc ggtcgtggcc
     1861 gtggagggcg acagcgcctt cgggttcagc ggcatggagc tggagacgat ctgccgctac
     1921 aagttgcccg tcgtcacgat catcatgaac aacggcggtg tctaccgcgg cgacgacgtc
     1981 aacccgctcg acgacgcccc gtcgccgacg accctcatgc tcgcggcccg ccacgacctg
     2041 atgatcgagg cgttcggcgg caagggttac cgcgcgacca cgcccgccga ggtcaccgcc
     2101 gccctcaccg aggcactggc ctcgggcggc ccggcgctca tcgactgcgt gatcgacccc
     2161 tcggccggca ccgagagcgg ccacatctcg cacctcaatc cgaagggcat cacggtcggc
     2221 aacatcacgc cggccaagaa gtgacctcct cggaagtgac tgtctccacc ccgaactcca
     2281 gctcccgcac agcccaccct cgcaccgaga tcattcacga gaaggaagcc accatgagtg
     2341 aaaagccgct cgccggaatc aaggtgatcg acttcaccgg ggtccaggcc ggtcccgcct
     2401 gtacccagat gctcgcctgg ttcggagccg acgtcatcaa ggtcgagcgc ccccagggcg
     2461 gcgacgtgac ccgcaatcag ctgcgggaca tccccgacct cgatgccctg tacttcacca
     2521 tgctgaacag caacaagcgt tcattggcca tcaacaccaa gacccccgag ggcaaggagg
     2581 tcatggagaa gctgatccgc gaggcggaca tcctggtcga gaacttcgcg ccgggcgcca
     2641 tggaccggat gggcctcggg tgggaccaca tccacgagct gaacccgcgg ctgatcttcg
     2701 gttcggtcaa gggcttcaac gacgcctcgt cgtggtcgga cctcaaggtg tacgagaacg
     2761 tggcgcaggc agccggcggc gccgcgtcga ccaccgggtt ctgggacggg ccgccgacca
     2821 tcagcggttc ggccctgggt gacagcaaca ccggtatgca cctgctgatc ggtctgctga
     2881 ccgcgatcat ccagcgcaac gcgacgggcc tcggccagaa ggtgtcggtg tccatgcagg
     2941 acgccgtgct caacctgacc cgggtcaagc tccgtgacca gcagcgcctg gagaaggtcg
     3001 gctacctgga ggagtacccg cagtacccgc acggcgagtt cggcgacgcg gtgccgcgcg
     3061 gcggcaacgc gggcggcggc ggtcagccgg gctggatcct gaagtgcaag ggctgggaga
     3121 ccgaccccaa cgcctacatc tacttcacgg tccaggaaca gaactggaag cgcaccgccg
     3181 aagccatcgg ccaccccgag tgggtcgacg acccggacta caccactgcc cgggcccggc
     3241 agccgcgcat catggagatc ttcggcgaga tcgagaagtg gctcgccgac aagaccaagt
     3301 acgaggcggt cgacatcctg cgcaagtggg aggtgccctg tgcgccggtg ctcagcatga
     3361 aggagctcgc cgaggacccc gacatgcgca agagcggcac gatcgtcgag gtcgagcaga
     3421 aggagcgcgg cacctacctg acggtgggca gcccgatcaa gttctccggc ttcaagcccg
     3481 acatccaggg tgcgccgctg ctcggcgagc acaccgacga ggtgctcgcg gacctcggct
     3541 acgacgcgga cgacatccgc aagctgcacg agggccaggt cgtcgcctga cccggaacac
     3601 cacggtgccc cgcgtacgga cctcgtacgc ggggcaccgg caggtgaggg cgcgtcggca
     3661 tctgaggggt gccgagcact ttccggggtg cccggagcgc cccgaagcgg acggaatttt
     3721 acggttccac ccagcgacgg cagagtgggg aggccatcgg ctgaggtcat cgccacctgg
     3781 gtttccttgc cgctggttcg atcggatcag cgtgcactgt gacccggagg tcggtggggt
     3841 gttttagccg tgcccctcac gccgaatgcc ggccgatggc caagggcaaa cggcgagctc
     3901 gaacacccgg agacagtgat cggcgtgccg gtacgggata cgcctcgcgt gcgtggacgg
     3961 ggcctacacg gctgcggggg agggtgggtc tgaccggcat ccaacagcac cgaagcggat
     4021 acggtctaac gcgctcggtc atcggcagcg atggtttgca ggcgggcccc ggatcctccg
     4081 gggtctccaa gccggcaaaa cagtaggcag aaggtactga tggttatcgc gctcgttccc
     4141 tggctactgc tgcccgtcgc ctgggccgcg ctgccctggc tgcctccgaa ccggacgttc
     4201 ggctgcttcg tggcagcggt gcagctgatg ctgtccgtag cggccctctc cgtcggaatg
     4261 ccggcggaga atctgccggc atggttcctc attccggggc tggtctcctc tgtggcgcga
     4321 ctggcgtctg tgtcctcgct gcgcgcgagg acaagacggg gccaagcgtg agagcccttg
     4381 tgcatctcac agccggtcag ctgctgtcgg gatagctgcg ggggcttctc ctgttccgcg
     4441 tggttgctga ccaccgcgtc aggagttcga tccgagcgcg gtccggcgac gccaccccac
     4501 gatcggatcg accgcgccgc cgtccaggcc gtgccgacgg aggagctgga cctgatgggg
     4561 ctggccgtgt gcaggccgcg gaacgcggtg gacaaggtgc tgaagggcgc gcggatgcat
     4621 atgtgactga gtctgcaact gaatctgcac agcgagggcg caactgcgac acgggtgcgt
     4681 tctgttggtg cggagttgtc ctggtcggag ctgccgtggc aatagctgtc gatttcctgt
     4741 gcggcgctac atgtagagaa gctgccctca attcgtgtgc atgcacgcac ggatgagtag
     4801 ccgagtgttt caactgccct gctgggagcg gcgactgact ggatgctgcg gcacgctccg
     4861 tgatttgatc ctttgcgccg ccgggatcgc gccaaggtgt ccggaaacgg atggcgcgcg
     4921 cctgcggtcg cggcccagcg tctgtccccg gcttggccgc tccccccttg tggaacatcc
     4981 gtacgaaggg cagtttcatc atgaactccg ctccccaggt tcagaccctt gaaatctccg
     5041 acgccgagct cgacaccgtc tccggtggcc tgagcccgca ggttggcatc gctgctggcc
     5101 ccacggcgat cagcagctcg gacctcgtgg ctcagttcgg cgcggtcaag gacgagatcc
     5161 aggacaccgt cggccagtac caccaggccg gcgtcgctgt ctccttctga tcgccagatc
     5221 gcgggacttt ttcaatccgt gatcgccgat ggactgaccg gcagcctggc cgccgatcag
     5281 cgacggtagc aacaagcccc ctacccgaga ttctccgctg gtagggggct tgatcgttag
     5341 gggttgccgc tttttgcccc gggccttgtc ggggatcttg gggacgggca actcccgcgc
     5401 tcactgacgt gctcgggccc gcagctcctt cagccggctg tggaacgcgt tgtggcggtt
     5461 ctggtcgagg ttcgagcagg tggtttgcgc tggtcccact gcacaagcac aggactggag
     5521 gcggttcctg agcgcccaga tcgaactcgc accctcaggc gtcgtcgcgc tcgcgggtgc
     5581 aggggctccg gcgcgtgtgc agagaggacg cggtgctcgt gggccatgcg ggctcacgcg
     5641 tcgggatcgt cgaactggtc gagggcgtgc aggtcaccca ggcttcgagg ggtccgcaga
     5701 tcagcggtcc atctcagctg caacgaaccg tcgttgaccg tggatgaccg cccgatgtgg
     5761 cacgactgtg gcacgcatcg gccggttgcg tccttggaag ctgtctgggc cgcgccgagc
     5821 ctatgggctg ctctgtgcgg gcccggcgct tggaccggtg tcaagctttg cgatgtgctg
     5881 gcatcacggc tgttgacctt gcgttccgcc cggagttgga tcttccctgc ccgtacgggt
     5941 gtccgggcag ggggagggct acgacgatgg ctggtgctgc ccgagacggg ctgatacggg
     6001 tggtgccctt cgagcggatg tccgcgctga tgatggctgc gggcgcggtg ctgtctgaag
     6061 gggtgctgtt ggccctgatc gctacggcca accggctgga gacgctgttg gtgggaacgg
     6121 tcgtggtcat tcttatgtcg cttgcgatgc tgccgctgag cttccgtctt ccggcccggc
     6181 ggcgccacca gtacgagcat gccgtccgga tcgatagcgt cgcagtaccg ctcgaggggc
     6241 aggatgcgtc gaggcggcag tcgctctggc gtacggctgt ggctgtgggt gtgttggcct
     6301 gttggatgat gctcctcggc ttgacgttcc atgaggtgat gccgccggtc atgctggtcc
     6361 cgctggccgt gctcctgtgg gcgcggtccc gggcgaccgc acattgggag cgggtgaacg
     6421 gggcagccct gtggcagggc gttcccgggc tgctggggtc ccgaggcccg gtcttccgcg
     6481 tgccggcagc gggcgggatt tgaacccgcc gtctcttcgt cgcgaagcaa cttgggtgga
     6541 tgctcgacct tgtcaaactg cgcctctcac ctgctgtgat ggtccgtagg cgtccgcaca
     6601 tgtccgccgc tctctgtctg aggttccccc gcatctcacc cttccgatgg cagcgccacc
     6661 ctgcgccccc catcgtgctg gagcggagag gctcccacga tccgagagat tggccgaagc
     6721 gtcggtctat cgagcccgtc ctccgtggca taccgccctg agcagatgga acagcttggg
     6781 gttatccggc gcaccgcaag gcgtgggtgg gggaggggta tcgccctggg ctggcgacgg
     6841 gcgccaaggg ggcgatccca cctagactcg aacgtgtgaa cgatccactt ccgcttaccc
     6901 gtctcgacct gttgcgcttc ctggaacgcg tacaggagca ggacctgacg cgcatgcggc
     6961 gatggatcga ggccgagaag cagcgcgaag ccgaggggca gcgcggattc gacgcccggc
     7021 cgcccgcgcc ggactggctc atcgagcagg gcctctcagg ccgcgacccc gtgtacgtcc
     7081 acgtgggcgg gtgctggaac gccggaaagc ggagccgcgg agtcgagcgg gaccaagcgc
     7141 tgcgggcgct cgtcgatggg gtaccggcct gcacgcactg ccgacctggc agcgagctcg
     7201 ggtacctgga gtgatcagcg cagacgcgtg tccgggctgt cggagaggga ggttgggaat
     7261 atgccggaga gtgtgcctgt ggtcgtgcac ccgccgcagc cggacggtgg caggcgggtg
     7321 acgatccgtg gcgagccagt cggcacggct taccacgtgc tggacgtggt ggagttcctg
     7381 cgccgcgaag gcctgcctga ggcggatacg acgatcgacg accccgagct gatcgagtgg
     7441 cgcggcggcg ggcccaaagt gtggacggcg ccagggtgat ctgtcggtcg ccaggcagta
     7501 cgcggcttcc gccctgccgt ctttttggcc gtcctattcg ccgcggcctt cttggccggc
     7561 tgcttcttcg cggccttctt ggccgcggtc ttctccttcg gcatgtcatg gacggtggcg
     7621 tcctcgccgc gggaagccgc gccttcgcaa cggactcctt gagcgcggcc atcaggtcga
     7681 cgacctgacc cggcgcctcc ggctggggcg agttgggccc tgcgcgtgcc gtcaacgaac
     7741 cagcgcagga ccaggacggg atgcttgaac gggctgagtg cgcgggtgcc cttgcgggtg
     7801 ccgagccgct cgcggtgctg ctggaggagc cgggcgagga agtgggcggt ctgcctgctg
     7861 acgtcgagca cggcgctgta ggtgataccg ggtggcacgt gaagcctctc ggccggaatc
     7921 tgatcttcgc aggcgcgttc ctcccagggg cttcacgcct ctccgtccgc agtgacccct
     7981 ctggtcatca cactccgcag ccgacccgtt gccgagaaca tctcattgag gctcaggcga
     8041 gatcgaaccg atcgaggttc atcaccttgt cccacgctgc cacgaagtca cgcacgaact
     8101 tctctcccgc gtcctgagac gcgtagacct ccgagatggc tcggagctgg gagtgtgaac
     8161 cgaagacgag atcgacggcg gtggcggtcc acttgacctc gcccgtcacg cgatcccggc
     8221 cgtcgaacac attgtcagca gaggaagacg cgttccactc cgtgcccatg tcgagcaggt
     8281 tgacgaagaa gtcgttggtc agtgactccg tccggtgggt gaaaacaccg tgggaggatc
     8341 gctggaagca ggtgttcagg gcccgcatgc cgccgatcag aaccgtcatc tcgggagcgg
     8401 tcagtgtcag cacgttggcg cggtccagca ggagagtctc cggcgacagc ttctctcccg
     8461 cccggaggta attacggaac ccgtcctccc tgggttcgag cgcggcgaac gactccacgt
     8521 cggtctgctc ctgcgaggcg tccgtgcgcc ccggtacgaa cgggaccgtg atgtcgtgcc
     8581 cggcgttctt cgcggcttgc tcgacggccg cgcacccgcc caggacgatc aagtcagcga
     8641 gcgagacctt cgttccgccg gcctgcgagc cgtcgaagtc ctgccggatc tgctcgagag
     8701 cccgcaccac ctcggtcacc tcgggcaggt cgttgacctc ccagctgcgt tgcggctcga
     8761 gccgaatccg tgccccgttg gccccgccgc gcttgtcggt gccgcggaag ctcgctgccg
     8821 acgcccaagc ggtggtgacc agctgggaga tggacagtcc cgaggcgagg atcctggcct
     8881 tgaggacggc gatgtcctcg tccgcgactg gttcgtgatc gacctcgggc acgggatcct
     8941 gccacagctg gggctcggga acccacgggc caaggtaacg ggagcgtggt cccatgtcgc
     9001 ggtgcagcag cttgtaccac gccttgccga acgccgccgc gagctcgtcc gggttctcgt
     9061 ggaagcgttt cgcgatcggc gcatagaccg gatccacctt cagcgcgagg tccgtcgtca
     9121 gcatcatggg agcatgcctc ttcgacggat catgagcatc aggcacagtg gtcttggccg
     9181 ccggatccgt gggagtccac tgcttcgcac cggcggggct gaccgtcagc tcccagtcgt
     9241 atctgaacaa gttgtccagg tacccgttgt cccacttcgt cggctcggtg gtccatgcgc
     9301 cctcaagccc actggtgagc gcgtcggcgc ccttgccgct gccgtacgtg ttcctccagc
     9361 cgaggccttg ctgctccatg gggccggcct cgggctccgg gccgatgtac tgtgcatcga
     9421 ccgcgccatg acacttgccg aacgtatggc cgccgacgat gagcgcaacc gtctcctcgt
     9481 cgttcatcgc catacgcccg aatgtctcgc gaatgtccct ggcggcagcc atcggatccg
     9541 ggtcaccgtt gggcccctcc ggattgacgt agatcagtcc catttgcacg gcaccgagag
     9601 gaccggcgag ttccctgtcc ccgctgtaac gctcatctcc gagccatgtg tcctcgggcc
     9661 cccagaagat ttcctcgggt tcccagatgt cctctcgccc gaagccgaac ccgaaggtct
     9721 tgaaccccat cgattccatg gcacagttgc cggtgaagat cagaaggtcg gcccaggaga
     9781 ttttccggcc atacttctgt ttgacgggcc agagcaatcg ccgtgccttg tcgaggctca
     9841 cgttgtccgg ccagctgttg aggggggcaa aacgctgagc gcccgcgcca ccaccgcccc
     9901 ggccatcgtc gacgcggtac gttcccgcgg catgccaact catccggatg aagagcggcc
     9961 cgtagtggcc gtagtcggca ggccaccagt cctgcgacgc cgtcatcacc ccgaagatgt
    10021 cctgtttcag cgcgtcgagg tcgagggtgg agaattcttc ggcgtaattg aagtcctcgc
    10081 tcatcggatt ggaccgggga cagtgctgat ggagaacctg aaggtccagc tgattcggcc
    10141 accagtcccg gttcgtcttg ggtcgggtcg gcgtggcggc cggggagggg atgaccgggt
    10201 tctcgctttc
//
