LOCUS       NZ_BMMM01000010        23639 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces albiflavescens strain CGMCC 4.7111 sequence10, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMM01000010
VERSION     NZ_BMMM01000010.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces albiflavescens
  ORGANISM  Streptomyces albiflavescens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 389502)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 100X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645835.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:24:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,828
            CDSs (total)                      :: 9,745
            Genes (coding)                    :: 9,386
            CDSs (with protein)               :: 9,386
            Genes (RNA)                       :: 83
            rRNAs                             :: 1, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 102 of 359
            Pseudo Genes (incomplete)         :: 321 of 359
            Pseudo Genes (internal stop)      :: 17 of 359
            Pseudo Genes (multiple problems)  :: 80 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:54:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 116518
            Orig. end                         :: 140157
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMM01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23639
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="blactam"
                     /region_number="1"
                     /rules="(BLS or CAS or tabtoxin)"
                     /tool="antismash"
     cand_cluster    1..23639
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(BLS or CAS or tabtoxin)"
                     /kind="single"
                     /product="blactam"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23639
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:13639](-)"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13639)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
     gene            complement(15..995)
                     /locus_tag="IEY95_RS26180"
                     /old_locus_tag="GCM10011579_053040"
     CDS             complement(15..995)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579748.1"
                     /locus_tag="IEY95_RS26180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053040"
                     /product="EamA family transporter"
                     /protein_id="WP_189188582.1"
                     /transl_table=11
                     /translation="MSVKDRLLAVLVAVLWGLNFLAVRIGLDHYPPFFLSALRFLVLAV
                     PVILFVPRPKAPVRWLLVYGLGFGALQFGLLFLAIDQGMPSGQASVVVQASAPFTMLLG
                     ALLLGERVSPRQLGGIALAVLGMAVIAVERARSAALLPLLLTLLAALGWALGNIASRQA
                     RPDHPLRFALWMSVVPPLPLLALSAVMEGPTTGWRALGGSFDGDGWPGLVALVYTALAG
                     SVVGSGIWTTLLKRYEAGVVAPFSMLVPVVGVAAAWAVLGEELTGWSLTGGSAVVLGVL
                     LGTGWTPRTRNGRGDLRDRPRRPRTRRTGNQSPEPTAPVQNTQRS"
     gene            complement(992..2383)
                     /locus_tag="IEY95_RS26185"
                     /old_locus_tag="GCM10011579_053050"
     CDS             complement(992..2383)
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952519.1"
                     /locus_tag="IEY95_RS26185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053050"
                     /product="serine hydrolase"
                     /protein_id="WP_189188583.1"
                     /transl_table=11
                     /translation="MIQAPGSVPSGATAAEAALAADDSPMGDAARWASGLLTAPDLAPD
                     ESTAARFVPTFPARHTRGFSATLAEWRTKGPFTVRDYQPVAHKGWVVLSGPTGVRYTLS
                     LTLDSTGLIRILALQPETVIPETGTWDELEDALRTPGVDHSVLAARLTPEGMVVLHESA
                     GARPMPTGSAYKLYVMRALVHAIENGELSWDDEVTVRPELRSLPTGDMQDLPDGTRVTV
                     RETAYKMIAMSDNTGADLIADRLGRDAVERAVTASRHHDPSLLRPFLTSHEVFELGWSA
                     PELRTAWAGRDEAGRRELLREIARPMTVRGSDLGETVHRLGLDWHMTAHDVLHVLEGLR
                     HDSERDATGTVEHILTAYPGIPVDQAKWPRVYFKAGSCPGVMMFCWLLQDRDGTVHVLV
                     LRQAADEQKPIGDGLFLRGLGARVINSGLLEADPQSGEAAEHGEGAGRGEGAGRGEGAD
                     GKAAR"
     gene            complement(2438..2770)
                     /locus_tag="IEY95_RS26190"
                     /old_locus_tag="GCM10011579_053060"
     CDS             complement(2438..2770)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024851.5"
                     /locus_tag="IEY95_RS26190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053060"
                     /product="ferredoxin"
                     /protein_id="WP_373294548.1"
                     /transl_table=11
                     /translation="MSEVSDVSGIGDVNGTSDMSDVNRTSGVSETNGMGDASRAAAARR
                     LTITVDPDACCAMGRCAGTEPELFDQDPDTGTVVLLDPTPAPARHAAARLCAELCPCGA
                     ITLTED"
     gene            complement(2767..3945)
                     /locus_tag="IEY95_RS26195"
                     /old_locus_tag="GCM10011579_053070"
     CDS             complement(2767..3945)
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952517.1"
                     /locus_tag="IEY95_RS26195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053070"
                     /product="cytochrome P450"
                     /protein_id="WP_229703382.1"
                     /sec_met_domain="p450 (E-value: 5.8e-28, bitscore: 92.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRVSPVDPPPQLAALRAGRAASRVTLWDGSEVWLVTSHAGVRAV
                     LGDRRFTAVTSAPGFPMLTRTSQLVRAAPHTASFIRMDDPDHSRLRSMLTRDFLARRAE
                     DMRPVLRELLDDMLGGLVAAGEKPVDLVAGLTIPVPSRVIALLFGVGEDRRDFIEGRSA
                     ILIDRGYTPDQVAAARDELDGFLRELVESRVADPGTDLVSRLVTDQVRPGRLSVEELVP
                     MCRLLLVAGHGTTTSQASLSLLSLATDPGLADALTKDESLLPKAVEELLRFHSIVQNGL
                     ARAAIEDVQLDDVTIKAGEGVVLSLSAGNRDERVFPAPDTLDPHRDARRHLAFGHGIHQ
                     CLGQWLAKVEIEEMLAAVLRRLPGVRLAVPFEELDFRHEVSSYGLGALPVTW"
     misc_feature    complement(3985..4001)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.31"
                     /tool="antismash"
     misc_feature    4161..4177
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     misc_feature    complement(4221..4235)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.32"
                     /tool="antismash"
     gene            4266..5030
                     /locus_tag="IEY95_RS26200"
                     /old_locus_tag="GCM10011579_053080"
     CDS             4266..5030
                     /NRPS_PKS="Domain: PKS_KR (15-181). E-value: 2.3e-18.
                     Score: 58.7. Matches aSDomain:
                     nrpspksdomains_IEY95_RS26200_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575244.1"
                     /locus_tag="IEY95_RS26200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053080"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_229703383.1"
                     /sec_met_domain="adh_short (E-value: 8.6e-41, bitscore:
                     134.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTTAPRTASALQGKVALITGASSGIGEATARVLAAEGAAVAVAA
                     RRVDRLHALRDELAATGATVHVLALDVTDERAVRDAVHSTVETLGRLDILVNNAGVMLL
                     GPVEGADTTDWTRMIDTNVLGLMYMTHAALPHLLKSQGAVVQISSIAARVAGRGAAGYN
                     ASKFAVNGFSEGLRQEVTERGVRVVVIEPGTVETELREHITHAPTKAAIEERVGKIRQL
                     RAADIAEAVRYAVTAPSHMTVNEIFIRPTDQA"
     aSDomain        4311..4808
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS26200_PKS_KR.1"
                     /evalue="2.30E-18"
                     /label="IEY95_RS26200_PKS_KR.1"
                     /locus_tag="IEY95_RS26200"
                     /protein_end="181"
                     /protein_start="15"
                     /score="58.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGASSGIGEATARVLAAEGAAVAVAARRVDRLHALRDELAA
                     TGATVHVLALDVTDERAVRDAVHSTVETLGRLDILVNNAGVMLLGPVEGADTTDWTRMI
                     DTNVLGLMYMTHAALPHLLKSQGAVVQISSIAARVAGRGAAGYNASKFAVNGFSEGLRQ
                     EVT"
     CDS_motif       4317..4385
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IEY95_RS26200_0001"
                     /evalue="2.30E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IEY95_RS26200"
                     /protein_end="40"
                     /protein_start="17"
                     /score="13.8"
                     /tool="antismash"
                     /translation="LITGASSGIGEATARVLAAEGAA"
     gene            5343..6656
                     /locus_tag="IEY95_RS26205"
                     /old_locus_tag="GCM10011579_053090"
     CDS             5343..6656
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152688.1"
                     /locus_tag="IEY95_RS26205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053090"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_229703384.1"
                     /transl_table=11
                     /translation="MGQCGDLAEVARRTGSRHGALERQLDRLDKTVGLPLTLRSRHTAR
                     LTSAGSRLLVAGRRFFRQVDLAVQTNIFGRGSEAVDAPAVLAVASAEPLLEDVVEDAAA
                     TLDILLSVHHDTPHQVMRRLAGYHVDAAHTWSLDAPRNSVERAVRAYGVLDDPLWVTLP
                     FDHPLAGRNAVSLADLQGENWVSEVGPDSEVLVARVFQAAGLPAPAALHITGASVARGM
                     LRRGDAIGLGSPTHPAVLARSVVHRSVVERPHRSTSLLVDPTVVPGALAEQLAALLADR
                     YLRRFAEQHRDLLGDPWWTRWHREQTARVTRPVRESDAPEASLVPTATRKFDVDDLHVL
                     RAVAKHGSINRAAAVLSISQSALTRRIHRLELGLGACLLVRSARGTDLTSPTRRFLHQL
                     ARFEAEFHDAAAACRSIGLPTTHRPADAPRAQLAPSAT"
     gene            complement(6632..8320)
                     /locus_tag="IEY95_RS26210"
                     /old_locus_tag="GCM10011579_053100"
     CDS             complement(6632..8320)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952514.1"
                     /locus_tag="IEY95_RS26210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053100"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_189188585.1"
                     /transl_table=11
                     /translation="MESTRSTSTGSTGNTGGDGFDAGARGVVKPTDALGGTLRLVRTDD
                     FDSLDPGNTYYAYTWNFLRLIGRTLVTFDTAPGKAGQRLVPDLAESLGESSEGGRVWTY
                     RLRAGLRYEDGSPVTSGDVKYAIARSNYGTDVLGAGPTYFRQLLGTDYGGPWREPGSDG
                     PVTLETPDERTLVLRLEEPFAGMDLLATMPSTTPVPRRLDTGAEYRLRPVATGPYRVVS
                     YTRGELAVLERNPHWDPATDPVRRQRAERIEAHLGKDPHEVDRMLLAGEAHIDLAGFGV
                     QPSTQERILADPVLRAHADNPLTGFTWIYCLSSRIAPFDNVHCRRAVQFATDKAAMQAA
                     YGGSVGGDIATTILPPTIDGFQDFDRYPVGAEGTGDLEAARAELAAAGMPDGFRTKIAA
                     RKDRLKEYRAAEALAAGLARVGIEAEVLDFPSGDYFDIYGGCPAYLREHGIGIIMFGWG
                     ADFPDGYGFLQQIVDGRAIKERGNQNMGELDDPEINGLLDRGATSGDPAERAEIWHRID
                     RLTMEHAVIVPYLYPRSLLYRHPDARNVYVTGSFGMYDYVALGAS"
     misc_feature    complement(8351..8365)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.42"
                     /tool="antismash"
     misc_feature    8353..8367
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.44"
                     /tool="antismash"
     gene            complement(8616..9800)
                     /gene="argJ"
                     /locus_tag="IEY95_RS26215"
                     /old_locus_tag="GCM10011579_053110"
     CDS             complement(8616..9800)
                     /EC_number="2.3.1.1"
                     /EC_number="2.3.1.35"
                     /GO_function="GO:0004358 - glutamate N-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1220: bifunctional ornithine"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009720811.1"
                     /locus_tag="IEY95_RS26215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053110"
                     /product="bifunctional glutamate
                     N-acetyltransferase/amino-acid acetyltransferase ArgJ"
                     /protein_id="WP_189188586.1"
                     /transl_table=11
                     /translation="MPDSEEKKTPQGFVVHTAPVGLADDGRDDFTVLASTAPAQVSGVF
                     TRSRFAGPSVLLSREAVADGRARGVVVLARNANVATGREGEANAREIRESVARTLGVPE
                     GELLIASTGVIGRQYPMPQIREQLKSLSLPFPEGGFDRAARAIMTTDTRPKVVRLRCGD
                     ATLVGIAKGVGMIEPDMATLLTFFATDARLDAAEQDRIFRRVMDRTFNAVSIDTDTSTS
                     DTAVLFANGLAGEVDPVAFEEVLYEAALALVKDIASDGEGASKLIEVQVTGARDVAQAK
                     RVGKTVVNSPLVKTAVHGSDPNWGRVAMAIGKCSEDTDIDQDAVRIRFGDVEVYPPRAS
                     DARDEDAVRAAVAGHLQGDEVVIGIDLGVADGAFTVYGCDLTEGYVRLNSEYTT"
     misc_feature    9838..9851
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.21"
                     /tool="antismash"
     gene            complement(10001..10981)
                     /gene="cs1"
                     /locus_tag="IEY95_RS26220"
                     /old_locus_tag="GCM10011579_053120"
     CDS             complement(10001..10981)
                     /EC_number="1.14.11.21"
                     /GO_function="GO:0033758 - clavaminate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0033050 - clavulanic acid biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="cs1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     blactam: CAS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1046: Dioxygenase TauD/TfdA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952512.1"
                     /locus_tag="IEY95_RS26220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053120"
                     /product="clavaminate synthase Cs1"
                     /protein_id="WP_189188587.1"
                     /sec_met_domain="CAS (E-value: 1.2e-197, bitscore: 650.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="TauD (E-value: 1.1e-12, bitscore: 42.7,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASPIIDCTPHREQLRALAAELPEVPRADLFGFLEKAKELSAKLP
                     RELAAALDKFNAEGTEDGYLLLRGLPLEADDELPTTPTSTPAPLDRGRLVMEAMLAVAG
                     RRLGLHTGYAELRSGTVYHDVYPSPGAHYLSSETSETLLEFHTEMAYHVLQPNYVMLAC
                     SRADHERRAETLVGSVRKALPLLDAETKARLFDRKLPCCVDVAFRGGVDDPGAIANVKP
                     LYGDENDPYLGYDRELLAPEEPADKEAVAALSKALDDVTEAVKLTPGDLLIIDNFRTTH
                     ARTPFSPRWDGKDRWLHRVYIRTDRNGQLSGGERAGDVVSFAPRR"
     misc_feature    11002..11017
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.21"
                     /tool="antismash"
     gene            complement(11004..11945)
                     /gene="speB"
                     /locus_tag="IEY95_RS26225"
                     /old_locus_tag="GCM10011579_053130"
     CDS             complement(11004..11945)
                     /EC_number="3.5.3.11"
                     /GO_function="GO:0008783 - agmatinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008295 - spermidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="speB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952511.1"
                     /locus_tag="IEY95_RS26225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053130"
                     /product="agmatinase"
                     /protein_id="WP_189188588.1"
                     /transl_table=11
                     /translation="MERIDSHVSPRYAQIPTFMRLPLDQDPRGYDVVVIGAPYDGGTSY
                     RPGARFGPRAIRNESGLIHGVGIDRGPGTFDLINCVDGGDIDLTPFDMNIAIETAQRHL
                     AELLKSNAAFMMLGGDHSLTVAALRAVAEQHGPVAVVHLDAHSDTNPAFYGGQYHHGTP
                     FRHGIDEKLIDPAAMVQIGIRGHNPKPDSLDYARGHGVRVVTADEFGDLGVSGTAGLVR
                     ELVGRRPVYVSVDIDVCDPAFAPGTGTPAPGGLSSREVLGLLRCVGDLKPVGFDVMEVS
                     PLYDHAGITSVLATEIGAELLYQYARAHRIQM"
     gene            complement(12107..13639)
                     /locus_tag="IEY95_RS26230"
                     /old_locus_tag="GCM10011579_053150"
     CDS             complement(12107..13639)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     blactam: BLS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952510.1"
                     /locus_tag="IEY95_RS26230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053150"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_189188589.1"
                     /sec_met_domain="GATase_7 (E-value: 5.7e-15, bitscore:
                     49.8, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="BLS (E-value: 1.4e-164, bitscore: 542.2,
                     seeds: 11, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 6.2e-25, bitscore:
                     83.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASQDLPAAFGFLASARPSGGRIPRAAFATRGTHTGVDLRLRSQT
                     LGATLVHAPGLPPDSAQAHDADTAVLLAGEIYNRDDLYSVLGPNTERSSDAQLVLDLLR
                     RYGRHAFRLVNGRFAAVVGTGRQVLLATDHAGSIPLYVCASPGEVTAATEAKTLAGHGG
                     PRGFPFADARRVRGLPGVYQVPAGAVMDIGLDAGTAETHRTWAPPLARRIMDEDDAVAA
                     VRTALDRAVGARITPGGTPLVVLSGGIDSSGVAALAHRAAGAIDSLSMGTEVSDEFAQA
                     KAVADHLGTRHREITVPTADLLGQLPYAVWAAESEDPDIIEYLLPLVALYRALDGPPRR
                     VLTGYGADIPLAGMHREDRLPDLDTAVAYDMATYDGLNEMSPVLSAVSGHWSTHPYWDR
                     DVLDLLVSLEAGLKRRYGRDKWVLRAAMAELLPEQTVKRPKLGVHEGSGTTSSFSLLLL
                     EEGVAEQSVGAAKQQVVRELFDRTVVAGEDPGEVSTAEVVRSVADRLERGAA"
     gene            complement(13642..15363)
                     /locus_tag="IEY95_RS26235"
                     /old_locus_tag="GCM10011579_053160"
     CDS             complement(13642..15363)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090800.1"
                     /locus_tag="IEY95_RS26235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053160"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_189188590.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.5e-42, bitscore:
                     139.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.2e-33, bitscore:
                     109.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRVSTGPSNKPTAAHALLARLRDHGVEKVFGVVGREAASILFDE
                     VEGIDFVLTRHEFTAGVAADVLARITGRPQACWATLGPGMTNLSTGIATSVLDRSPVIA
                     LAAQSESHDIFPNDTHQCLDSVSIIAPMSKYAVELERPHEITDLVDSAVTAAMTEPVGP
                     SFISLPVDLLGSSEGIDASVEHPAANTPAKPIGAVADGWQKAADEAAELLKGAKHPVLV
                     VGAAAIRSGAVPAIRALAERLNIPVITTYIAKGVLPHGHELNYGAVTGYMDGILDFPAL
                     DTLFAPVDLILTVGYDYAEDLRPSMWQKGGEKKTVRVSPTANPIPRVYRPTVDVVTDVL
                     AFVEHLDTATASLAAKERHDIAPLRARVAEFLADPTVYEDGMRVHQVMDSMNTVMEEVA
                     GSGEGTIVSDIGFFRHYGVLFARADQPFGFLTSAGCSSFGYGVPAAMGAQLARPGQPTF
                     LIAGDGGFHSNSADLETIARLNLPIVTVVVNNDTNGLIELYQNIGHHRSHDPAVKFNGV
                     DFVALAEANGVEATKASDRQELLAALRKGAELGRPFLIEVPINYDFQPGGFGALSI"
     misc_feature    complement(15616..15631)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.43"
                     /tool="antismash"
     gene            15898..17463
                     /locus_tag="IEY95_RS26240"
                     /old_locus_tag="GCM10011579_053170"
     CDS             15898..17463
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020477458.1"
                     /locus_tag="IEY95_RS26240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053170"
                     /product="penicillin-binding transpeptidase
                     domain-containing protein"
                     /protein_id="WP_373294549.1"
                     /transl_table=11
                     /translation="MALAATAGIGYWAYNALARDDGDDPQVAAATGQLDKFLDAWEAGD
                     AKAAAGLTDTPDNAESLIKSVMTNLEPSKTEITAGTGKREAEGEVKIPFTVKMALSGAG
                     DYKWDSSAKLIKKSGRWTVEFHTPLIHPQMVPGQTLALKSRERAAVLDKNGDELQSASL
                     VGAVDPKTGKGISGLQARYDKQLTGGGGKAQSVVIVERESGRVVKQLTGSGSSAGKPVK
                     TTIDPKVQEAAAEALDGVKKNAAIVAIDPSNGDILAAANMPSGMNRALEGRYPPGSTFK
                     VVTSAALLKQGMRPTDRADCPKFAYVNGQRFENQNQFVLPSGSTFRDAFAKSCNTFFVG
                     ARGKLSNTALHDTAQAFGIGGSWDVGTTTYDGSIPVTNSDNDKAASTIGQARLQASPLV
                     MASIAATVKEGEFKQPVLVPEAVKKKYEAPARLDADVVGNLRQMMRATVTYGAGWALKD
                     LPGEPHAKTGTAEFGSDTPPHTHAWMIGYQGDSDIAWSVLLEDGGSGGSDAGPIAAKFL
                     KNLN"
     misc_feature    complement(17618..17631)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.39"
                     /tool="antismash"
     gene            17731..18540
                     /locus_tag="IEY95_RS26245"
                     /old_locus_tag="GCM10011579_053180"
     CDS             17731..18540
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952500.1"
                     /locus_tag="IEY95_RS26245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053180"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_189188592.1"
                     /transl_table=11
                     /translation="MNSRNDLTIQLLGPVTLLRNDIPIPIRGQRQRRFLASLALKPGQV
                     TTKEAIIEDSWDGEPPLTVSGQLQTSAWMIRTALAEAGLTRDALGSHALGYELRVPAQR
                     IDVFVFRDAVRQVRELHARGQHQIASERLDDALAMWRGAALTDVTSTRLRMKGEALDRE
                     RTAAAELRALIDVGLGHYGEAISQLSELVDHDPLREDLYVGLMKAYYGEGRQADAIRVF
                     HRAKEILREQIGINPGARLRDLMQAILRQDESLLRATGIPLSGDRVG"
     gene            18788..19786
                     /locus_tag="IEY95_RS26250"
                     /old_locus_tag="GCM10011579_053190"
     CDS             18788..19786
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952502.1"
                     /locus_tag="IEY95_RS26250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053190"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_189188593.1"
                     /transl_table=11
                     /translation="MAGRRTVLKGVLAASGAAASAAGLVGAAPTNGRGAPYSTPVQMRW
                     LGVSGWEIVVDGGRSILFDPYLSRMPYRDAKGAIDPKLPLRLDRAAVERVAARHLTGPP
                     ELILVSHGHFDHVADVPQLLGRPAWEKHRIRAMCDETVRNLLTAMGTPRPRMDDVIQVK
                     GGEYLQFDGYTVEVFRSLHSQQPDHGYFAPGRKTAPPRRPTVLGDLVEGDTLAYQLTVD
                     GGPSILLMGASNFAERELSGIRPDIAAIAMTSHSALHRYLERLLAAIGDPPLLIPTHHD
                     DMTTPLTDAPSLLAAATPTMAAKELTAASAPASRVLSPHHLKAVDVTAALT"
     gene            19798..21330
                     /locus_tag="IEY95_RS26255"
                     /old_locus_tag="GCM10011579_053200"
     CDS             19798..21330
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141030.1"
                     /locus_tag="IEY95_RS26255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053200"
                     /product="APC family permease"
                     /protein_id="WP_189188594.1"
                     /transl_table=11
                     /translation="MHPSPGPGATDKGLKDGALGLFSSTVIGLASTAPAYSLAATLGVI
                     AGIVGHQSPIVIILAFVPMFLIAYGYKELNRADPDCGTTFTWASRAFGPHTGWLGGWGI
                     VAADIIVMANLAQIAGAYGFQLVGADGLAQDTFWVTVVGVAWIAVMTLVCYIGIEISAN
                     LQKVLLTIEIVVLFLLAITALVKVYGGTAPSVSSELSGSWFNPFRIDSLDDLTKSVLAG
                     VFIYWGWDTAVSVNEETVDRDRTPGHAAVISTITLLLVYLMVTTSAQAFAGVGDRGIGL
                     ANPDNSDDVLSSLGAEVFGTAGWGEVATKLLILMVLTSAAASTQTTILPSARTALSMAT
                     FKAVPDRFARIHPRFLTPTWSTVGMGLASIAFYVMLTRVSGNVLADSIGSVGLVIAFYY
                     GLTGFACVWYYRRVLTRRPHDLWTKGVMPALGGVLLLYFFVNACVVYSAADYGSTSWTL
                     PFPPRRQLGGVFVTGIGALLLGAVLMLAYQVIRPAFFHKETIPVSAYERDGR"
     gene            complement(21345..21938)
                     /locus_tag="IEY95_RS26260"
                     /old_locus_tag="GCM10011579_053210"
     CDS             complement(21345..21938)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0008752 - FMN reductase (NAD(P)H) activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173557.1"
                     /locus_tag="IEY95_RS26260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053210"
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="WP_229703385.1"
                     /transl_table=11
                     /translation="MGIGGSAGPGSTTERAVRIALESAAGRGARTQLIGGPELILPLYD
                     ATVAGRSAGGRKLIASVASADGIIIGTPAYHGSISGMVKNALDYVEELRTDERPYFSGR
                     AVGCISVARGCQGAGSALAALRTTVHALRGWPTPLGVTVNTEPTPFDSGERLDDLRVRE
                     RLELLGNQVVEFALMSRAWTAHPSREVERLPPGA"
     gene            complement(21964..22176)
                     /locus_tag="IEY95_RS26265"
                     /old_locus_tag="GCM10011579_053220"
     CDS             complement(21964..22176)
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004658 - propionyl-CoA carboxylase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018551714.1"
                     /locus_tag="IEY95_RS26265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_053220"
                     /product="acyl-CoA carboxylase epsilon subunit"
                     /protein_id="WP_189188596.1"
                     /transl_table=11
                     /translation="MGDGNVSQVIRVEKGSMEPDELAALTAVLLARAAGSDAGRDDAAR
                     RPRSSARWSRPERAAMFASPRSWQR"
ORIGIN
        1 ctggggtacg tgccttatga ccgctgggtg ttctggaccg gggcggtcgg ttccggggac
       61 tgattcccgg tccggcgggt gcgggggcgt cgcggccggt cgcgcaggtc tccgcgcccg
      121 ttccgggtcc tgggggtcca gcccgttccc agcagcaccc ccaggaccac tgccgaaccg
      181 cccgtcagcg accaccccgt cagctcctcc cccagtaccg cccacgccgc cgcgaccccc
      241 accaccggga ccagcatgga gaacggggcc acgactcccg cctcgtagcg cttcagcagg
      301 gtggtccaga tgcccgagcc gaccaccgag cccgcgagcg cggtgtacac cagggccacc
      361 aggccgggcc agccgtcgcc gtcgaaggag ccgccgaggg cgcgccagcc ggtggtcggg
      421 ccctccatca cggcggacag ggccagcagc ggcagcggcg gcacgacgga catccacagg
      481 gcgaaacgca gcgggtggtc ggggcgtgcc tgccggctgg cgatgttgcc gagcgcccag
      541 ccgagcgccg ccagcagggt cagcagcagc gggagcagcg cggcgctgcg ggcccgttcc
      601 accgcgatca ccgccatgcc gagcacggcc agggcgatcc cgcccagctg ccgcggggag
      661 acccgctcgc ccagcagcag cgcgccgagc agcatggtga acggggccga cgcctgcacc
      721 acgaccgagg cctgccccga cggcatgccc tggtcgatgg cgaggaagag cagcccgaac
      781 tgcagggccc cgaagcccag cccgtaaacc agcagccagc gcaccggcgc cttcggccgg
      841 ggcacgaaga ggatcaccgg cacggcgaga acgaggaagc gcagtgcgga gaggaagaag
      901 ggcgggtagt ggtcgagtcc gatccgtacg gcgaggaagt tcagccccca cagcacggcg
      961 acgagaacgg cgaggagccg gtccttgacg ctcaccgggc ggctttcccg tcggctcctt
     1021 cgccgcgccc tgctccttcg ccgcgccctg ctccttcgcc gtgctccgct gcttcgccgg
     1081 actgtgggtc ggcctccagc agacccgagt tgatgacccg cgcaccgagc ccgcgcagaa
     1141 acaggccgtc gccgatgggc ttctgctcgt cggccgcctg acgcagcacc aggacgtgca
     1201 cagtgccgtc ccggtcctgg agcagccagc agaacatcat cacaccgggg caggaaccgg
     1261 ccttgaagta gacccggggc cacttggcct ggtcgacggg gatgccgggg taggcggtca
     1321 ggatgtgctc gacggtaccg gtggcgtccc gctcgctgtc gtgccggagc ccttcgagga
     1381 cgtggagcac gtcgtgcgcg gtcatgtgcc agtcgaggcc cagccggtgc accgtctcgc
     1441 ccaggtcaga gccgcgcacc gtcatcggcc gggcgatctc gcgcagcagc tcccggcgtc
     1501 cggcctcgtc ccgccccgcc cacgcggtgc gcaactccgg ggcgctccag ccgagttcga
     1561 agacctcatg gctggtcagg aagggacgca aaagggaggg atcatggtgg cgggaggcgg
     1621 tcacggcacg ctcgacggca tcgcggccca gccggtccgc gatcagatcg gcgccggtgt
     1681 tgtcgctcat cgcgatcatc ttgtacgccg tctcgcgcac cgtgacacgg gttccgtccg
     1741 gcagatcctg catgtcgccc gtgggcagac tgcgcagttc gggccgcacg gtgacctcgt
     1801 cgtcccagct cagctcaccg ttctcgatcg cgtggacgag ggcgcgcatc acatagagct
     1861 tgtacgcgga gccggtgggc atcggccggg ccccggccga ctcgtgcagg acgaccattc
     1921 cctcgggcgt gaggcgcgcg gcgaggacgg agtggtccac gcccggtgtg cgcagcgcgt
     1981 cctccagctc gtcccaggtg cctgtctcgg ggatcaccgt ctcgggctgg agcgcgagga
     2041 tgcggatcag cccggtcgag tcgagggtca gcgacagcgt gtatcgcacg ccggtgggtc
     2101 cggacagcac gacccagccc ttgtgggcga cgggctggta gtcccggacc gtgaacggcc
     2161 ccttcgtacg ccattccgcc agcgtcgcgg agaaaccccg cgtgtgccgg gcggggaagg
     2221 tcggcacgaa ccgtgcggcc gtggactcgt ccggggcgag gtcgggcgcc gtcagcagcc
     2281 ctgacgccca ccgggccgcg tctcccatcg gggagtcgtc ggcggcgagc gccgcctcgg
     2341 cggcggtggc tccggacggg acggaaccag gggcttggat catgatcgct ccttgtcggc
     2401 cgctgagcgg cgaagtgcgc cgctggggcg cgggctctca gtcctcggtg agcgtgatgg
     2461 ctccgcacgg gcacaactcg gcgcagagcc tggccgctgc gtgccgtgcg ggtgcggggg
     2521 tggggtcgag caggaccacg gtgccggtgt cggggtcctg gtcgaagagt tccggctcgg
     2581 tccccgcaca tcggcccatg gcgcagcacg cgtccgggtc gacggtgatc gtcagacgac
     2641 gcgcggcggc cgcgcggctc gcgtcgccca tgccattcgt ctcgctcacg ccgctcgtgc
     2701 ggttcacgtc gctcatgtcg ctcgtgccgt tcacgtcgcc gataccgctc acgtcgctca
     2761 cttcgctcac caggtcaccg ggagcgcgcc gagcccgtaa ctggacacct cgtggcggaa
     2821 gtccagctcc tcgaacggca ccgccagccg cacaccaggc agccggcgca gtacggcggc
     2881 cagcatctcc tcgatctcga ccttggcgag ccactgcccc aggcactggt ggatgccgtg
     2941 accgaaggcc agatgccggc gggcgtcgcg gtgcgggtcg agggtgtcgg gcgccgggaa
     3001 gacccgctcg tcgcggttgc ccgccgagag cgagaggacg acaccctcgc cggccttgat
     3061 cgtcacgtcg tccagctgta cgtcctcgat ggcggcgcgg gccagcccgt tctgcacgat
     3121 ggagtggaag cgcagcagct cctcgacagc cttgggcaac aggctctcgt ccttggtcag
     3181 ggcgtcggcg aggccggggt cggtggccag gctgagcaga ctgaggctgg cctggctggt
     3241 ggtcgtgccg tgccccgcca ccagcagcag ccggcacatc gggaccagct cctcgacgct
     3301 cagccggccc ggccgtacct ggtcggtcac cagtcggctc accagatcgg taccgggatc
     3361 ggcgacccgc gactcgacga gctcacgcag gaaaccgtcc aactcgtccc gggccgcggc
     3421 cacttgatcg ggggtgtagc cacggtcgat gagaatcgcg ctgcggccct cgatgaagtc
     3481 ccggcggtcc tcgcccactc cgaacagcag ggcgatgacc cgggacggca cggggatcgt
     3541 cagaccggcg acgagatcga cgggcttctc accggccgcc accaggccgc ccagcatgtc
     3601 atcgagcaac tcccgcagca ccggccgcat gtcctcggcc ctgcgcgcga ggaagtcacg
     3661 cgtgagcatc gagcgcagcc gggagtggtc cgggtcgtcc atgcggatga acgaggccgt
     3721 gtggggcgcc gcgcgtacga gttgcgaggt gcgggtcagc atcgggaaac cgggggcgct
     3781 ggtgaccgcg gtgaaccggc ggtcgccgag cacggcccgg acaccggcgt gcgaggtcac
     3841 cagccacacc tcgctgccgt cccacagcgt cacccggctc gcggcgcgtc cggcccggag
     3901 cgcggcgagc tgcggcggcg ggtccacggg agagacgcgt ggcatcgggt acgacggtgc
     3961 cgccgccctc tctccccgga gcgctgcatc gttctgcatc atccaccgcc tatcgctgcg
     4021 caggtcgctg cgcaggggtc gcgccgacgt gctgtcgtcg acccaatctg ccgtgcccgc
     4081 ggggaggcgt cctggcctgc ggccgggcat gcataaccgg ccggaaacag tcataacttg
     4141 aggcgccgac agccattcac cgcacaatgt cgcggctgat agcgtcacgg catccggccc
     4201 tttccagcgc caccacacac cattctcagg acattcgcgc gccctatccg tcacccaccg
     4261 ggggaatgat gaccacagca ccgcggacgg cttcagcact gcaggggaaa gtcgcgctca
     4321 tcacgggcgc gagctccgga atcggcgagg ccacggcacg ggtgctggcc gccgagggcg
     4381 ccgccgtggc cgtcgcggcc cgccgggtcg accggctgca tgccctgcgg gacgagctgg
     4441 cggccaccgg cgccaccgtc cacgtactcg cactggacgt caccgacgag cgggcggtcc
     4501 gcgacgccgt gcactcgacc gtggagaccc tggggcggct cgacatcctg gtgaacaacg
     4561 ccggggtgat gctgctgggt cccgtcgagg gcgccgacac cacggactgg acccgcatga
     4621 tcgacaccaa cgtcctgggc ctgatgtaca tgacccacgc ggcgctgccg cacctgctca
     4681 agagccaggg cgcggtcgtg cagatctcct cgatcgccgc gcgcgtggcg ggccgcggcg
     4741 ccgccggcta caacgccagc aagttcgcgg tgaacgggtt cagcgaggga ctgcgccagg
     4801 aggtcaccga gcgcggtgtg cgcgtggtgg tcatcgagcc gggtaccgtc gagaccgaac
     4861 tgcgcgagca catcacgcac gcgccgacca aggccgccat tgaggaacgg gtcggcaaga
     4921 tccggcagtt gcgggccgcc gacatcgccg aggcagtgcg ctacgccgtg acggcgccct
     4981 cccacatgac ggtcaacgag atcttcatcc gcccgaccga ccaggcctga cggtccggtc
     5041 cggtccggat ctatccggac cgtcttcgga cgctctcccc gccccggcgc gaggagagca
     5101 cgaagagagg acgcgcctaa gatcgccgca gcgaattcat tgagccactg cggacaatca
     5161 agcggcacag tccttgacca aaaaggaaac cgacattgtc ttacgggtca gaaataacgc
     5221 ctgcaatgac gcctgcgata aagcctgcga taacgtctgc gataacgtct gttcccgacc
     5281 ggccggaacc ctttcccctt cccttcccct tcacccgacc cgacctgtcc ctgctggacg
     5341 cggtgggaca gtgcggcgac ctcgcggaag tggcccggcg caccgggtcg cggcacggcg
     5401 ccctggagcg ccaactcgac cgcctcgaca agaccgtcgg tcttcccctg accctgcgca
     5461 gccgccacac cgcgcggctg acctctgcgg gctcgcgcct gctggtggcc gggcgccggt
     5521 tcttccgcca ggtcgatctt gccgtccaga cgaacatctt cgggcgcggc tcggaggcgg
     5581 tcgacgcgcc cgccgtgctg gccgtcgcgt ccgccgaacc gctcctggag gacgtggtcg
     5641 aggacgccgc ggccacgctg gacatccttc tgtcggtcca tcacgacacg ccccaccagg
     5701 tcatgcgcag gctggccggc taccacgtcg acgccgcgca cacctggagc ctcgacgcgc
     5761 cgcgcaactc ggtcgagcgg gccgtgcgcg cctacggcgt cctcgacgat ccgctgtggg
     5821 tcacgctgcc gttcgaccac ccgctggccg gccggaacgc ggtctcgctc gccgatctgc
     5881 agggcgagaa ctgggtgtcc gaggtcggcc cggactccga ggtcctggtg gcccgggtct
     5941 tccaggccgc cggtctcccc gcccccgccg ccctgcacat caccggtgcc tcggtggccc
     6001 gcggaatgct gcgccgcggc gacgccatcg ggctcggctc ccccacgcat ccggccgtgc
     6061 tcgcgcgctc cgtggtccac cggtccgtgg tggagcgtcc gcaccgctcc accagcctcc
     6121 tcgtcgaccc gacggtcgta cccggcgccc tggccgagca gctagccgcg ctgctcgccg
     6181 accgctatct gcggcggttc gccgagcagc accgtgacct gctgggcgac ccgtggtgga
     6241 cgcgctggca ccgggagcag accgcccggg tcacccgtcc cgtacgggag agcgacgcgc
     6301 ccgaagcgtc gctcgtgccg accgcgacca ggaagttcga cgtcgatgac ctgcacgtac
     6361 tgagggcggt ggcgaagcac ggcagcatca accgggccgc cgccgtgctg tccatcagcc
     6421 agtccgcgct gacccgtcgc atccaccgcc tcgaactcgg cctgggcgcc tgcctgttgg
     6481 tgcgcagcgc ccgcggcacg gacctgacca gccccacccg ccgcttcctg caccaactgg
     6541 cccgcttcga ggccgagttc cacgacgcgg ccgcggcctg ccggagcatc ggcctgccta
     6601 cgacccaccg gccggccgac gccccccggg ctcaactcgc cccgagcgcc acgtagtcgt
     6661 acatgccgaa cgacccggtg acgtagacgt tgcgggcgtc cgggtgccgg tagagcagcg
     6721 agcgcgggta cagatacggc acgatcaccg cgtgctccat ggtcagccgg tcgatgcggt
     6781 gccagatctc cgcgcgctcg gccggatcgc cggaggtggc gccgcgatcg agcagcccgt
     6841 tgatctccgg atcgtccaac tcgcccatgt tctggttgcc gcgctccttg atcgcccgcc
     6901 cgtccacgat ctgctgcagg aacccgtagc cgtccgggaa gtcggccccc cagccgaaca
     6961 tgatgatccc gatcccgtgc tcgcgcagat aggccgggca gccgccgtag atgtcgaagt
     7021 agtcgccgga gggaaagtcc aggacctcgg cctcgatccc gacccgcgcg agcccggcgg
     7081 ccagcgcctc ggcggcccgg tactccttga gccggtcctt gcgggctgcg atcttcgtac
     7141 ggaacccgtc cggcatcccg gcggcggcga gttcggcgcg ggccgcttcg agatccccgg
     7201 tcccctcggc accgacggga tagcgatcga agtcctggaa cccgtcgatg gtcggcggaa
     7261 ggatggtggt ggcgatgtcc ccgccgaccg aaccgccgta cgccgcctgc atggcggcct
     7321 tgtccgtggc gaactgcacg gcacgccggc agtgcacgtt gtcgaacggc gcgatcctgc
     7381 tcgacaggca gtagatccag gtgaacccgg tgagcgggtt gtcggcatgg gcccgcagca
     7441 ccggatcggc gaggatccgc tcctgcgtgg agggctgcac cccgaacccg gcgaggtcaa
     7501 tgtgcgcctc cccggccagc agcatgcggt ccacctcgtg cgggtccttg ccgaggtgcg
     7561 cctcgatgcg ctcggcccgc tgcctgcgga ccgggtcggt cgccggatcc cagtgcgggt
     7621 tgcgttccag cacggccagt tcgccgcggg tgtacgagac gacgcggtac gggccggtgg
     7681 cgaccggtcg cagccggtac tcggcgccgg tgtcgaggcg gcgcggcacc ggcgtcgtgc
     7741 tgggcatggt cgccagcaga tccatccccg cgaacggctc ctcgagccgg aggacgaggg
     7801 tgcgctcgtc gggggtctcc agcgtgacgg gcccgtcgga gccgggctcc cgccaaggcc
     7861 cgccgtagtc ggtccccagc agctgccgga agtaggtggg ccccgccccc agcacgtcgg
     7921 tcccgtaatt gctcctggcg atggcgtact tgacgtcccc ggacgtcacc ggagagccgt
     7981 cctcgtaccg gagtcccgcc cgcaaccggt acgtccacac ccgaccgccc tcggacgact
     8041 cccccagcga ctccgcgagg tccggcacca gccgctggcc cgccttgccc ggagccgtgt
     8101 cgaaggtgac cagcgtgcgg ccgatgagcc tcaggaagtt ccaggtgtag gcgtagtagg
     8161 tgttcccggg gtccagcgag tcgaagtcgt ccgtacgcac cagccgaagc gtgcccccca
     8221 gggcatcggt cggcttcacc acgccacgcg ctcccgcgtc gaatccgtcg ccgcccgtat
     8281 tgcccgtact gcccgtactc gtcgaccgag tgctctccat atccctacag ccctcctcgc
     8341 ggatgccttc ctccacatct tgtgggggcg ggcgtgcgag gaagggggcg cgggcggggg
     8401 cacgcatagc cgtcgacggg tcggtatagc cggggtcggc gtcagggatg ttttcgcccc
     8461 ctccgcccct gcccgacccg tacctggggg ctacgccccc agacccccgc tcaaagattg
     8521 cgcagttccc cgcgcacccg cagccgaagg ccggtccggg acgggtaggg gcggaggggg
     8581 cgaaaaaccc actcacccgc acccccacac acccgtcagg tcgtgtactc cgagttcagc
     8641 cgcacatacc cctcggtgag atcgcacccg tagacggtga aggcgccgtc ggcgacgccg
     8701 aggtcgatcc cgatgaccac ctcgtccccc tggagatgcc cggctacggc ggcccgcacc
     8761 gcgtcctcgt cccgggcgtc ggaggcacgg ggcgggtaca cctcgacgtc cccgaagcgg
     8821 atgcgtaccg cgtcctggtc gatgtcggtg tcctcggagc acttcccgat cgccatggcg
     8881 acccgccccc agttggggtc gctgccgtgc accgcggtct tcaccagcgg tgagttgacg
     8941 acggtcttgc ccacccgctt ggcctgggcg acgtctcgcg ccccggtgac ctggacctcg
     9001 atgagcttgc tcgccccttc cccgtcgctc gcgatgtcct tgacgagggc cagcgcggcc
     9061 tcgtacagaa cctcctcgaa ggcgacggga tcgacctccc cggccagccc gttggcgaac
     9121 agcaccgccg tgtcactggt ggaggtgtcc gtgtcgatgc tcaccgcgtt gaaggtgcgg
     9181 tccatcaccc gccggaagat ccggtcctgc tcggccgcgt cgagccgggc gtcggtggcg
     9241 aagaacgtca gcagcgtcgc catgtccggc tcgatcatcc cgacgccctt ggcgatcccg
     9301 acgagcgtcg cgtccccgca ccgcagccgg accaccttcg gccgggtgtc ggtcgtcatg
     9361 atggcgcgag cggcacggtc gaaaccgccc tccgggaacg gcagggacag cgacttgagt
     9421 tgctcgcgga tctgcggcat ggggtactgc cggccgatca ccccggtgga ggcgatgagg
     9481 agttcgccct cgggcacgcc gagcgtgcgc gccacggact cacggatctc gcgcgcgttc
     9541 gcctcgccct cccgcccggt cgcgacgttc gcgttgcggg ccagcaccac cacaccccgc
     9601 gcccggccgt cggcgaccgc ctcccggctc agcaggacgc tcggcccggc gaaccgggag
     9661 cgggtgaaca ccccactgac ctgggccgga gccgtcgagg ccagcacggt gaagtcgtcc
     9721 cggccgtcgt cggcgagacc gaccggcgcg gtgtgcacga cgaacccctg cggcgtcttc
     9781 ttctcttcgg agtcgggcat ggtcatcgtc tcctgtctgc attacttcca atgaagcagc
     9841 atattcatgc atcgcggata cggcgacgcg aacgagccga acaagccatt tgagccctgc
     9901 gagccctgcg gccccacggc cccacggccc tacgagccga acgaaccgca gccccctccc
     9961 ggaacggaga gggggcgcgg tcgaccggcc ggcgacgtgg ctatcggcgc ggagcgaacg
    10021 agacgacgtc ccccgcccgc tcgccacccg acagctggcc gttgcggtcc gtccggatgt
    10081 acacccggtg cagccaccgg tccttgccgt cccagcgcgg gctgaacggc gtccgggcgt
    10141 gcgtggtacg gaagttgtcg atgatgagca gatcgccggg ggtcagcttc acggcctccg
    10201 tgacgtcgtc cagggccttc gacagagcgg cgaccgcctc cttgtcggcc ggctcctcgg
    10261 gggcgaggag ctcgcggtcg tagccgagat aggggtcgtt ctcgtccccg tacagcggct
    10321 tgacgttggc gatggcgccc gggtcgtcga cgccgccgcg gaaggcgacg tccacgcaac
    10381 agggcagctt gcggtcgaac agccgcgcct tcgtctcggc gtcgaggagt ggcagcgcct
    10441 tgcgcaccga accgacgagc gtctcggccc tgcgctcgtg gtcggcgcgg gagcaggcga
    10501 gcatgacgta gttcggctgg aggacgtggt acgccatctc ggtgtggaac tcaaggaggg
    10561 tctcggaggt ctccgaggag aggtagtgcg cgcccggcga cggatacacg tcgtggtaga
    10621 ccgtgccgga gcgcaactcg gcgtaaccgg tgtgcagtcc gagcctgcgg ccggcgacgg
    10681 cgagcatcgc ctccatgacc agccggccac ggtccagcgg cgccggggtg gaggtgggcg
    10741 tggtgggcag ctcgtcgtcc gcctccaatg gcagcccgcg cagcagcagg tagccgtcct
    10801 cggtgccctc ggcgttgaac ttgtccagcg ccgcggccag ttcgcgcggc agcttcgcgg
    10861 acagctcctt cgccttctcc aggaagccga acaggtccgc gcgcggcacc tcggggagct
    10921 cggccgcgag ggcgcgcaac tgctcccggt gcggggtgca gtcaatgatc ggagaagcca
    10981 tgggtgcgat atctcctttt catctacatc tgtatgcgat gggcgcgggc gtactggtag
    11041 agcagttccg caccgatctc ggtcgccagg acggaggtga tcccggcgtg gtcgtacagg
    11101 ggcgagacct ccatcacgtc gaagccgacc ggcttgaggt cgccgacgca gcgcagcagc
    11161 ccgaggacct cccgcgaact gagcccgccc ggggcggggg tgcccgtccc gggcgcgaac
    11221 gccgggtcgc acacgtcgat gtcgaccgac acgtacacgg gccgccggcc caccagttcc
    11281 cggacgaggc cggcggtccc ggagacgccc aggtcgccga actcgtcggc ggtcacgacg
    11341 cgtacgccgt gtccgcgggc gtagtcgagc gagtccggct tcgggttgtg gccacggatg
    11401 ccgatctgca ccatcgcggc cggatcgatg agcttctcgt cgatcccgtg ccggaagggt
    11461 gtgccgtggt ggtactgacc gccgtagaag gcggggttgg tgtcggagtg ggcgtccagg
    11521 tgcacgacgg cgaccgggcc gtgctgttcg gcgacggcgc gcagggccgc cacggtcagc
    11581 gagtggtcgc cgccgagcat catgaaggcg gcgttgctct tcagcagctc cgccagatgt
    11641 cgctgagcgg tctcgatcgc gatgttcatg tcgaacgggg tcagatcgat gtcgccgccg
    11701 tcgacgcagt tgatgaggtc gaaggtcccg gggccacggt cgatgccgac accgtggatg
    11761 agcccggact cgttgcggat ggcgcggggc ccgaaccgcg cgcccggccg gtagctcgtg
    11821 ccgccgtcgt agggagcgcc gatgaccacg acgtcgtaac cgcgcgggtc ctggtcgagc
    11881 ggcaggcgca tgaaggtggg gatctgggcg tagcggggcg agacatgcga gtcgatgcgt
    11941 tccacggctc agtccctctc cggggtctcg acggcggtca gggacaggtt tgcgagaggg
    12001 gcgtacggac gggcgtacgg gcccacggcc acacgacagc cgtacgggcc cacggccaca
    12061 cgacagccgt acggccccaa agccgccacc ggagggacgt acggcctcat gccgcccccc
    12121 gttccagccg gtccgccacc gaccgcacca cctcggcggt gctcacctcg ccggggtcct
    12181 cgccggccac cacggtgcgg tcgaacagct cccgcaccac ctgctgtttc gccgcgccga
    12241 cggactgctc cgcgacgccc tcctccagga gcagcagcga gaaggacgag gtggtgcccg
    12301 acccctcgtg gacacccaac ttggggcgtt tgacggtctg ttcgggcagc agctcggcca
    12361 tcgcggcgcg cagcacccac ttgtcccgcc catagcggcg cttgaggccc gcctccagcg
    12421 agacgagcag gtcgagcacg tcgcggtccc agtaggggtg ggtggaccag tgtccggaca
    12481 cggcggacag caccggcgac atctcgttga gtccgtcgta cgtcgccatg tcgtacgcca
    12541 cggccgtgtc cagatcgggc agccggtcct cgcggtgcat gcccgcgagc gggatgtcgg
    12601 cgccgtaccc ggtcaggacc cggcgcggcg gtccgtcgag cgcgcggtag agggcgacga
    12661 gcggcagcag gtactcgatg atgtcggggt cctcggactc cgccgcccat accgcgtacg
    12721 ggagttggcc cagcaggtcg gcggtgggga cggtgatctc ccggtgccgg gtgccgaggt
    12781 ggtcggcgac cgccttggcc tgggcgaact cgtcggacac ctcggtgccc atcgacagcg
    12841 agtcgatcgc gcccgccgcc cggtgcgcga gggcggcgac cccggaggag tcgatgccgc
    12901 cggagagcac caccagcggc gtaccgcccg gggtgatgcg cgcgcccacg gcccggtcga
    12961 gggccgtgcg tacggcggcc acggcgtcgt cctcgtccat gatccgacgg gcgagcggcg
    13021 gggcccaggt acggtgcgtc tcggccgtgc cggcgtcgag gccgatgtcc atcacggcgc
    13081 ccgcgggcac ctgatagacg cccggcagcc cgcgcacccg gcgggcgtcc gcgaagggga
    13141 agccccgtgg accgccgtgc ccggccaggg tcttggcctc ggtcgccgcg gtgacctcgc
    13201 cggggctcgc gcacacgtac agcgggatcg atccggcgtg gtcggtggcc agcaggacct
    13261 gccggccggt gccgacgacc gccgcgaacc gcccgttgac gaggcggaag gcgtgccggc
    13321 cgtagcggcg cagcaggtcc aggaccagct gcgcgtcgct ggaccgctcg gtgttggggc
    13381 ccaggacgga gtacaggtcg tcgcggttgt agatctcacc ggcgagcagt acggcggtgt
    13441 ccgcgtcgtg tgcctgggcg gagtcgggtg ggagcccggg ggcgtgcacc agggtcgcgc
    13501 cgagggtctg cgagcgcagg cgcaggtcga cgccggtgtg ggtgccccgg gtggcgaagg
    13561 cggctcgggg gatccggccc ccgctcggac gagcggaggc caggaaaccg aaggccgcag
    13621 gaaggtcctg ggaggccatg atcagatgct cagcgccccg aacccaccgg gctggaagtc
    13681 gtagttgatg gggacctcga tcaggaaggg gcggcccagc tcggcgccct tgcgcagcgc
    13741 ggcgagcagc tcctggcggt cggacgcctt ggtggcttcc acgccgttgg cctcggcgag
    13801 ggcgacgaag tcgacgccgt tgaacttcac cgcggggtcg tggctgcggt ggtggccgat
    13861 gttctggtag agctcgatga gaccgttggt gtcgttgttc acgaccaccg tcacgatcgg
    13921 caggttgagg cgggcgatgg tctccaggtc ggcgctgttg gagtggaagc cgccgtcgcc
    13981 ggcgatcagg aaggtgggct ggcccgggcg cgcgagctgg gcgcccatgg cggcggggac
    14041 gccgtagccg aagctggagc agccggccga ggtgaggaac ccgaagggct ggtcggcgcg
    14101 ggcgaacagg acgccgtagt gccggaagaa gccgatgtcg gagacgatcg tgccctcgcc
    14161 cgacccggcg acctcctcca tgaccgtgtt catcgagtcc atgacctggt ggacccgcat
    14221 gccgtcctcg tagaccgtcg ggtccgcgag gaactccgcg acccgggcgc gcagcggcgc
    14281 gatgtcgtgc cgctccttgg ccgcgagcga ggcggtcgcc gtgtcgaggt gctcgacgaa
    14341 cgcgaggacg tcggtgacga cgtcgacggt gggccggtag acgcgcggga tcgggttcgc
    14401 ggtgggcgag acgcggacgg tcttcttctc gccgcccttc tgccacatgg agggccgcag
    14461 gtcctcggcg tagtcgtagc cgacggtgag gatgagatcc acgggcgcga acagcgtgtc
    14521 cagggccggg aagtcgagga tgccgtccat gtagccggtg acggcgccgt agttgagctc
    14581 gtggccgtgc ggcaggacgc ccttggcgat gtacgtcgtg atgaccggga tattgaggcg
    14641 ctcggcgagg gcacggatgg cgggcaccgc accggagcgg atcgccgcgg ctccgacgac
    14701 cagcaccggg tgcttcgcgc ccttcaggag ctcggcggcc tcgtcggcgg ccttctgcca
    14761 gccgtccgcg accgcgccga tcggcttggc cggggtgttc gccgccgggt gctcgaccga
    14821 ggcgtcgatg ccctcggagg agccgagcag gtcgaccggc agggagatga acgaggggcc
    14881 gacgggctcg gtcatggccg cggtcacggc ggagtccacc aggtcggtga tctcgtgcgg
    14941 acgctccagc tccaccgcgt acttggacat cggcgcgatg atcgacacgg agtccaggca
    15001 ctggtgggtg tcgttgggga agatgtcgtg cgactcggac tgggcggcca gggcgatgac
    15061 cggggaacgg tccaggacgg acgtggcgat gcccgtggag aggttggtca tgccagggcc
    15121 cagggtggcc cagcaggcct gcgggcggcc ggtgatgcgc gcgagaacgt cggcggcgac
    15181 accggcggtg aattcgtgcc gggtgaggac gaagtcgatt ccctcgacct cgtcgaagag
    15241 gatcgacgcg gcctcgcggc cgactacccc gaacaccttc tccacgccgt ggtcacgcag
    15301 tcgcgccagg agggcgtgcg cggcggtcgg cttgttgctg gggccggtcg atacacggga
    15361 catggatggt ctccagactc ggtcagcggt ggacagttcg cgccaaccct gaccagaccc
    15421 cctctccact ccctctctct cggatatcgg ggagcgcgcg gagagaaaca ggagatcagt
    15481 ggagcggagg gctccgtttc ggccttggcc aatacagaca ccctgcgtcc gatttcgctt
    15541 atcgcgacgc catgaatctg atgagttcag gccactgttg gccctcgcgt gcgtcatgcc
    15601 gacgggcttt ccttcggagg tctagaccag ttgaccacgg tggtcgaccg ttctcggcca
    15661 gaccgcccac gcgtattcgg ccgagatggc tccggcgaca agcggaagag ggtgtcaccc
    15721 gccactctcc gccaaccatt tctttcctct ttaccttgtc ttgaagcatg tgctcgggga
    15781 gagaccgaag agagagaggc gattaatctg cgccatatga atcgttccga tgtctatgtt
    15841 gactacccgc ggtacgacag gcgtcggtcc cgtcgtcgcg cggctgtatc aacgtttgtg
    15901 gcacttgcgg cgaccgcggg aatcggctac tgggcctaca acgccctggc cagggacgac
    15961 ggagacgatc cacaggtcgc cgcggccacg ggacagctgg acaagttcct ggacgcatgg
    16021 gaggcgggcg acgccaaggc ggccgccggg ctgacggaca cgccggacaa cgccgagtcg
    16081 ttgatcaaat ccgtcatgac gaacctggag ccgtcgaaga cggagatcac cgccggcacc
    16141 ggcaagcggg aagcggaagg ggaggtgaag attccgttca ccgtgaagat ggccctttcc
    16201 ggggccggcg attacaagtg ggactcgtcg gcgaagctca tcaagaagag cggtcggtgg
    16261 accgttgaat tccatacacc gctgattcac ccgcagatgg ttccgggcca gaccctcgca
    16321 ctgaagtcac gggagcgcgc cgccgttctc gacaagaatg gcgacgaact ccagtccgcc
    16381 tctctcgtgg gcgccgtaga ccccaagacc ggcaaaggaa tctccggcct ccaggcccgc
    16441 tacgacaagc agctcaccgg tggcggtggc aaggcgcagt cggtcgtgat cgtggaacgc
    16501 gagagcggcc gcgtcgtcaa acagctcacc ggctcgggaa gcagcgcggg caagccggtg
    16561 aagaccacca tcgaccccaa ggtgcaggag gccgccgccg aagcactcga cggagtgaag
    16621 aagaacgcgg cgatcgtcgc catcgacccg agcaacggcg acatcctggc cgcggccaac
    16681 atgccctcag gcatgaatcg cgccctggaa ggccgttacc cgcccggctc caccttcaag
    16741 gtcgtcacct ccgccgctct gctgaagcag gggatgcgtc ccaccgaccg ggcggactgc
    16801 cccaagttcg cctacgtcaa cggccagcgc ttcgagaacc agaaccagtt cgtgctgccg
    16861 tcgggctcga ccttcaggga cgccttcgcc aagtcctgca acacgttctt cgtcggcgcg
    16921 cgcggaaagc tgtcgaacac cgccctgcac gacaccgccc aggccttcgg catcggcggc
    16981 tcctgggacg tgggcacgac gacgtacgac ggaagcatcc cggtgaccaa cagcgacaac
    17041 gacaaggcgg cgtccaccat cggacaggcc aggctccagg cgtcgcccct ggtcatggcc
    17101 tcgatcgcgg ccacggtcaa ggagggcgag ttcaagcagc ccgtcctggt gcccgaagcc
    17161 gtgaagaaga agtacgaggc ccccgcccgg ctcgacgcgg acgtggtcgg caacctgcgc
    17221 cagatgatgc gcgccacggt cacgtacggc gccggctggg ccctcaagga cctgcccggc
    17281 gagccgcacg ccaagacggg caccgccgag ttcggcagcg acaccccgcc ccacacgcac
    17341 gcctggatga tcggctacca gggcgacagc gacatcgcct ggtcggtcct tctggaagac
    17401 ggcgggtcgg gcggatccga cgcgggcccc atcgccgcga agttcctcaa gaacctcaac
    17461 tgacccaaag cgtccgtgac gtggcgcagg cacccggagc agagacagcg gcaacgatca
    17521 caccggccag agcagccacc acgagatcga cccatccgtg acccgcggcc acggagccac
    17581 cttgagccga cggtacgggg gacagcacca gcacgatgca cgaagcgtca ccggggccga
    17641 ccgccccacg ggtgacggtt ccccgcttcc gtcagcacct cagcccctgt tgggcgacgg
    17701 cttgattcac acatacaagg gggaaccgtc atgaacagca ggaacgacct gacgatccag
    17761 ctcctcggcc ctgtgaccct gttgagaaac gacataccga tacccatccg gggtcagcgg
    17821 cagcgtcgat tcctcgcttc cttggcgctg aagcccggac aggtcaccac caaggaagcg
    17881 atcatcgagg actcgtggga cggcgagccg ccgctgaccg tctccgggca gctgcagacc
    17941 tcggcctgga tgatccgtac ggccctggcc gaggccggtc tcacccgcga cgcgctcggc
    18001 tcgcacgccc tcgggtacga actgcgggtc ccggcccagc gcatcgacgt gttcgtcttc
    18061 cgcgacgctg tacggcaggt acgcgaactg catgcgcgcg gccagcacca gatcgcctcc
    18121 gagcgcctcg acgacgcgct cgccatgtgg cgcggcgcgg ccctcaccga cgtcacctcg
    18181 acccggctgc gcatgaaggg agaagcgctg gaccgggagc gcaccgcggc ggccgagcta
    18241 cgcgcgctga tcgacgtcgg tctcgggcac tacggcgagg cgatctcgca gctgtcggag
    18301 ctcgtcgacc acgacccgct gcgcgaggac ctgtacgtgg gcctgatgaa ggcctactac
    18361 ggcgagggcc gacaggccga cgcgatccgg gtcttccacc gcgccaagga gatcctgcgc
    18421 gagcagatcg gcatcaaccc gggagcacgg ctgagggacc tgatgcaggc catcctgcgc
    18481 caggacgaat cgctcctgag ggccaccggg attccgctgt cgggcgaccg ggtggggtga
    18541 gccgccgtcg gacgaccggg cgaggtgagc cgccgtcgga cgaccgggcg aggtgagccg
    18601 ccgtcggacg accgggtggg gtgagccgac ggccacagga tcgccgtgcc gagccgacgg
    18661 ggaaggtcct cgtcggcttg gtctcttggc gaccacagcg gcaccaatga ccgaaaacca
    18721 cctcatacgc cctcatctgc cgtagcgttc ttcgcactca aggtggtcac agggagcgtg
    18781 gcagaacatg gccgggcgac gtacggtcct caagggagtc ctggcggcat cgggtgcggc
    18841 ggcgtccgcg gccgggctgg tcggagccgc gccgacgaac gggcggggcg cgccgtactc
    18901 cacccccgtg cagatgcgct ggctcggcgt ctccggctgg gagatcgtcg tcgacggcgg
    18961 ccgcagcatc ctcttcgacc cctatctgag ccgcatgccc taccgggacg ccaagggcgc
    19021 catcgacccg aagctccccc tgcgcctcga ccgggcggcc gtggagcggg tcgccgcacg
    19081 gcacctgacc ggacctcccg aactgatcct ggtcagccat ggccacttcg accatgtggc
    19141 ggacgtaccg caactcctgg gacgccccgc ctgggaaaag caccgcatcc gcgcgatgtg
    19201 cgacgagacg gtacgcaatc tgctcacggc catggggacg cctcgacccc gtatggacga
    19261 cgtgatccag gtcaagggcg gcgagtacct ccagttcgac ggctacaccg tggaggtctt
    19321 ccgcagcctg cacagtcagc agcccgacca cggctacttc gcccccggcc gcaagaccgc
    19381 cccgcccagg cgccccaccg tgctcggcga cctggtcgag ggcgacacac tcgcctatca
    19441 gctgaccgtg gacggcggac cgagcatcct gctcatgggc gcgagcaact tcgccgagcg
    19501 tgaactgtcc ggcatccgcc cggacatcgc ggcgatcgcg atgacctcgc actcggcact
    19561 ccatcgctac ctggagcgcc tcctcgccgc catcggcgac ccgcccctgc tcatccccac
    19621 ccaccacgac gacatgacca cccccctcac cgacgctccg tccctcctcg cggccgcgac
    19681 ccccaccatg gcggccaagg aactcacggc cgcctccgcc cccgcctccc gggtcctcag
    19741 cccccaccac ctgaaggccg tcgacgtcac ggcggcactc acctgaggcc gcccgcagtg
    19801 cacccctcgc cgggcccggg agcgacggac aaggggctca aggacggcgc gctggggctc
    19861 ttctccagca cggtgatcgg cctggcatcc accgcccccg cctacagcct cgcggcgacc
    19921 ctcggcgtca tcgccggcat cgtgggccac cagtcgccga tcgtgatcat cctcgccttc
    19981 gtcccgatgt tcctgatcgc ctacggctac aaggagctca accgggcgga ccccgactgc
    20041 ggcaccacct tcacctgggc ctccagggcg ttcggccccc ataccggctg gctgggcggg
    20101 tggggaatcg tcgccgccga catcatcgtg atggccaacc tggcccagat cgccggggcg
    20161 tacggcttcc agctcgtggg cgcggacggg ctggcgcagg acaccttctg ggtcaccgtg
    20221 gtcggcgtgg catggatcgc cgtgatgacg ctggtctgct acatcggcat cgagatctcg
    20281 gcgaatctgc agaaggtgct gctcaccatc gagatcgtgg tgctcttcct gctggcgatc
    20341 accgcactgg tcaaggtcta cgggggaacg gcgccgagcg tctcgtcgga gctctccggg
    20401 tcgtggttca accccttccg gatcgactca ctcgacgacc tgaccaagag cgtgctggcc
    20461 ggggtgttca tctactgggg ctgggacacc gccgtatcgg tcaacgagga gacggtcgac
    20521 cgcgatcgca cccccggcca cgcggcggtg atctccacca tcaccctgct cctcgtctac
    20581 ctcatggtca cgacatcggc gcaggccttc gccggggtgg gggaccgcgg catcggcctc
    20641 gcgaaccccg acaactccga cgacgtcctc tccagcctgg gcgccgaggt cttcggcacc
    20701 gcgggatggg gcgaggtcgc caccaagctc ctgatcctga tggtgctcac gtcggccgcg
    20761 gcctccaccc agaccaccat cctcccgtcg gcccgaaccg ccctctccat ggccaccttc
    20821 aaggccgtcc cggaccgctt cgcccgcatc cacccccgct tcctcacccc gacctggtcc
    20881 accgtcggca tgggcctggc ctccatcgcc ttctacgtca tgctgacccg ggtgagcggg
    20941 aacgttctgg ccgactccat cggctcggtc ggcctcgtga tcgccttcta ctacgggctc
    21001 acggggttcg cctgcgtctg gtactaccgc agggtcctca cccgcagacc gcacgacctg
    21061 tggacgaagg gcgtcatgcc cgctctgggc ggcgtcctcc tcctctactt cttcgtcaac
    21121 gcctgcgtgg tgtactccgc cgcggactac ggcagcacct cctggaccct gccgttcccg
    21181 ccccgccgac aactcggcgg cgtcttcgtc accggcatcg gcgcactgct tctcggcgcc
    21241 gtgctgatgc tggcgtacca ggtgatccgc ccggcgttct tccacaagga gaccatcccg
    21301 gtctcggcgt acgagcggga cgggcggtga ggcaagggca ttcgctacgc ccccgggggc
    21361 agtcgttcga cctccctcga agggtgcgcg gtccatgccc ggctcatcag ggcgaactcg
    21421 accacctggt ttccgaggag ttccagtcgt tcgcgtaccc ggaggtcatc gagccgttca
    21481 ccggagtcga acggcgtggg ctccgtgttc accgtgacac cgagtggcgt gggccagccg
    21541 cgcagggcgt ggacggtggt cctcagcgcg gccagggcgg agccggcgcc ctggcatccc
    21601 ctcgcgacgg agatgcaccc cacggcacgt cccgagaagt acggccgctc gtccgtgcgc
    21661 aactcctcca cgtagtccag ggcgttcttc accatgcccg agatggaccc gtggtaggcc
    21721 ggggtaccga tgatgattcc gtccgccgac gccaccgagg cgatgagctt gcgcccgccc
    21781 gcggatcgcc cggccacagt ggcgtcgtag agcggcagta tcagctcagg accaccgatc
    21841 agctgcgtcc gcgcgcctcg cccggccgcg gattcgaggg cgatccgcac cgcccgctcc
    21901 gtggtcgagc cgggtcctgc ggatccaccg atccccacta ccgtgaccgc tcctgacacc
    21961 gattcacctc tgccagctgc ggggactcgc gaacatcgcc gcgcgctccg gcctgctcca
    22021 gcgggccgac gaacgcggcc gccgcgcggc atcgtcccgg cccgcgtccg aaccggccgc
    22081 gcgggccagc aggaccgcgg tcagggcggc cagttcgtcg ggttccatcg accccttctc
    22141 cacacgaatc acctgcgaca cgttcccgtc ccccatcgtc cggtcccctt ctcactgcgg
    22201 cggatttcca tgcttgcgac gaggcagatc ggcctccttg gcccgcagca tggccagcgc
    22261 gcggatcagc gtcgcccggg tctcgcgcgg gtcgatgacg tcgtcgacca gtccccgctc
    22321 ggcggcgtag tacggatgca ccagctcgcg cttgtactcc tcgatcttct gccggcgcat
    22381 cgcctcggga tcctcggcct ccgcgatgtc acggcggaac accacgttgg cggcaccctc
    22441 ggcccccatg acggctatct cgttgcccgg ccacgccagc gcgacgtcca cgccgatgga
    22501 ccgggagtcc atcacgatgt acgcgccgcc gtacgccttg cgcagcacca ccgagacacg
    22561 cggcacggtg gcgttgcagt acgcgtacaa cagcttggct ccgcgccgga tgatcccctc
    22621 gtgttcctgg tcgacacccg gcaggaagcc ggggacgtcg acgagggtga ccagcggaat
    22681 gctgaaggcg tcgcagaact gcacgaatcg cgcgcccttc tcgctggctt tgatgtccag
    22741 cacaccggcc atgacagtgg gctggttggc gaccaccccc acggtctgtc cgtccatgcg
    22801 ggccagcgcg cagacgatgt tgggggccca cccggcgtgg acctccatga tgtcgccgtc
    22861 gtcgacgagt tcctcgatca cccggcggat gtcgtaggaa cggctgccgt cggcagggac
    22921 caggtcgagc acggcctcac agagccggtc ggcggggtcc tcgcagggca cggcgggcgg
    22981 cagatcccgg ttgttggacg gcaacaagga gagcagatag cgcacttcgg cgaggcaggt
    23041 ctcctcgtcg tcgtacagga agtgcgccac ccctgacacc tcggcatgga cgtccgcgcc
    23101 gcccagtccg ttcagggtca cctcctcacc ggtcacggcc tgtaccacgt cgggtccggt
    23161 gatgaacatc tgagagacgt cccgcacggc gaagacgaag tcggtcaggg cgggcgcgta
    23221 ggcggcgccg cccgcgcacg ggccgaggat cacactgatc tgcgggatga cgcccgacgc
    23281 tctggtgtgg cgccggaaga tcccgccata cccggcctgc gccagaacac cctcctggat
    23341 gcgcgcgccg gccccgtcgt tgagggagac gagcggagcg cccgcagcca cggccatgtc
    23401 catgatcttg tggatcttct cggcatgcgc ctcgccgagt gtgccgccga agatccggaa
    23461 gtcatgggca cagacgaaga ccgtgcggcc ctccaccgtg ccccagccgg tgaccacgcc
    23521 gtcggtgtac gggcgcctcg cctccaaccc gaagccggtc gcgcggtgtc tgcgcagcgc
    23581 ctcgacctcg gtgaaactcc gcttgtccag cagcagttcg atccgctcgt gagccgtca
//
