LOCUS       NZ_BMMM01000005        22142 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces albiflavescens strain CGMCC 4.7111 sequence05, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMM01000005
VERSION     NZ_BMMM01000005.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces albiflavescens
  ORGANISM  Streptomyces albiflavescens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 501710)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 100X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645835.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:24:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,828
            CDSs (total)                      :: 9,745
            Genes (coding)                    :: 9,386
            CDSs (with protein)               :: 9,386
            Genes (RNA)                       :: 83
            rRNAs                             :: 1, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 102 of 359
            Pseudo Genes (incomplete)         :: 321 of 359
            Pseudo Genes (internal stop)      :: 17 of 359
            Pseudo Genes (multiple problems)  :: 80 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:54:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 206964
            Orig. end                         :: 229106
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMM01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="3"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22142
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12142](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(127..140)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.24"
                     /tool="antismash"
     gene            1149..3293
                     /gene="katG"
                     /locus_tag="IEY95_RS15975"
                     /old_locus_tag="GCM10011579_032390"
     CDS             1149..3293
                     /EC_number="1.11.1.21"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="katG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671049.1"
                     /locus_tag="IEY95_RS15975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032390"
                     /product="catalase/peroxidase HPI"
                     /protein_id="WP_189186939.1"
                     /transl_table=11
                     /translation="MGGASNRDWWPNRLNLTILRKHPSMADPMGEDFDYAAEFRTLDLD
                     ALARDVDGVLTTSQEWWPADFGHYGPLVIRMVWHGAGTYRIDDGRGGAGAGMQRFAPLN
                     SWPDNRNLDKARRLLWPVKKKYGRKVSWADLMIFAGNRALETMGFKTFGFAGGRADGWE
                     PDEDVYWGPERAWLGDERHGGVRELENPLAAVQMGLIYVNPEGPHTVPDPLTAARDIRE
                     TSRRMGMNDEETVALIAGGHSFGKTHGAADPDAHLGPEPEGAPLEEQGLGWKSSYGTGK
                     GGDTISSGLEGTWTPTPTRWDNSFFETLFGYEWDLELSPGGLWQWIPRDGRGAGTVPDA
                     HDPSTTHAPTILTTDLALRLDPVYEPISRRFLENPDQFADAFARAWFKLTHLDMGPIQR
                     YLGPLVPREKLIWQDPIPAVDHPLVGAADIAALKNRILASGLSVSQLVSTAWASASTFR
                     VSDKRGGANGARIRLEPQQGWEVNQPDTLAQVLRTLEGIQESFNSSQTGDKKISLADLI
                     VLGGAAAVEQAAKTAGHDVEVPFIPGRTDATQEWTDAESFAPLEPTADGFRNYRGKGNR
                     LPSEHLLVDRANLLDLSAPEMTVLVGGLRVLGANYRQSPLGVFTSLPGSLSNDFFVNLL
                     DTGTVWKSTSATAETFEGRDRVTGEVKWTGSRVDLVFGSNSELRAIAEVYASDDAEEKF
                     VQDFVAAWDKVMNLDRYDLA"
     gene            complement(<3542..>4176)
                     /locus_tag="IEY95_RS15980"
                     /pseudo=""
     CDS             complement(<3542..4176)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011726768.1"
                     /locus_tag="IEY95_RS15980"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAALPEQARPQPGDPAGPRLLARSDSTGATHAFAVACVERGVEFS
                     FGFSVDARIQGIVDAIPEDCWHPELMASSVTGRGWPRPPA"
     gene            complement(4329..4994)
                     /locus_tag="IEY95_RS15985"
                     /old_locus_tag="GCM10011579_032410"
     CDS             complement(4329..4994)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122984.1"
                     /locus_tag="IEY95_RS15985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032410"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_189186696.1"
                     /transl_table=11
                     /translation="MAGKVFFSVSMSLDGFIAPESVPVEGFFAPEKQDDPQVQRWMAQW
                     MELQQWIFPQRFFRENLKLGEGGEEGRDNDIVRETFERTGASVMGKRMFDLGQQAWPEE
                     APFHTPVFVVTHEKRDPWERPGGTTFHFVNDGIEPALDQAREAAGDRDVRIAGGGATIL
                     EYVNAGLIDEFSIALSPVLFGSGIRLFEGVDAGRVALEQVRAEPTQRVTHLTYTVHER"
     gene            complement(4994..5500)
                     /locus_tag="IEY95_RS15990"
                     /old_locus_tag="GCM10011579_032420"
     CDS             complement(4994..5500)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (19-157). E-value:
                     9.3e-08. Score: 24.5. Matches aSDomain:
                     nrpspksdomains_IEY95_RS15990_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068356.1"
                     /locus_tag="IEY95_RS15990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032420"
                     /product="SRPBCC family protein"
                     /protein_id="WP_189186697.1"
                     /transl_table=11
                     /translation="MSATGRGAPAQSGTADREIVISRVIDAPRELVFEAFTEVRHLSRW
                     WGPEGFTTTTRAFEFRVGGEWDFVMHGPDGTDYQEWISWTEIAPPERIALLHGESRGDP
                     NTFESVLTFAPDGAETRIEMRTVFPTKELRDEAVEKYHAIEGGQQTLSNLAAYVTEIVR
                     KGAEG"
     aSDomain        complement(5030..5443)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IEY95_RS15990_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="9.30E-08"
                     /label="IEY95_RS15990_Polyketide_cyc2.1"
                     /locus_tag="IEY95_RS15990"
                     /protein_end="157"
                     /protein_start="19"
                     /score="24.5"
                     /tool="antismash"
                     /translation="VISRVIDAPRELVFEAFTEVRHLSRWWGPEGFTTTTRAFEFRVGG
                     EWDFVMHGPDGTDYQEWISWTEIAPPERIALLHGESRGDPNTFESVLTFAPDGAETRIE
                     MRTVFPTKELRDEAVEKYHAIEGGQQTLSNLAAY"
     gene            complement(5504..5845)
                     /locus_tag="IEY95_RS15995"
                     /old_locus_tag="GCM10011579_032430"
     CDS             complement(5504..5845)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068355.1"
                     /locus_tag="IEY95_RS15995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032430"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_189186698.1"
                     /transl_table=11
                     /translation="MARAATTSDVFNAIAEPQRRELLVLLRAGERPVTELAQELGMTQP
                     GASKHLRVLREVGLVRDRKAGKQRLYGLDARGLRPVHEWTGGFERFWNESFDRLDAYVQ
                     DLKQARQEE"
     gene            5992..6234
                     /locus_tag="IEY95_RS16000"
                     /old_locus_tag="GCM10011579_032440"
     CDS             5992..6234
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY95_RS16000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011579_032440"
                     /product="hypothetical protein"
                     /protein_id="WP_229702998.1"
                     /transl_table=11
                     /translation="MGEQHAHGWRVSRHRLVADATVGVIANPMSGRDIRRLVASTSVFP
                     NAEKASMVVRLTAAAGALGVGSTATARSVNTRPGA"
     misc_feature    6445..6454
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     misc_feature    complement(6564..6575)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.51"
                     /tool="antismash"
     gene            6670..7131
                     /locus_tag="IEY95_RS16005"
                     /old_locus_tag="GCM10011579_032450"
     CDS             6670..7131
                     /GO_process="GO:1901661 - quinone metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559512.1"
                     /locus_tag="IEY95_RS16005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032450"
                     /product="MSMEG_3727 family PQQ-associated protein"
                     /protein_id="WP_189186699.1"
                     /transl_table=11
                     /translation="MTTAQERSDLLDQIGLAAQNKATLGQVLGTGRIGQATEKSDGRMQ
                     ATIRIHPDELTWDPDILVMPHGGDIDLELVNDDLNTHCALLPSNGDRKFIWLVNHSRGR
                     ATLNLDGPGYYWFGSPTGNDEGRGLTGAIVVLGDAPPEARLDRPEQPRP"
     gene            7154..8854
                     /locus_tag="IEY95_RS16010"
                     /old_locus_tag="GCM10011579_032460"
     CDS             7154..8854
                     /EC_number="1.1.2.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559513.1"
                     /locus_tag="IEY95_RS16010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032460"
                     /product="PQQ-dependent dehydrogenase, methanol/ethanol
                     family"
                     /protein_id="WP_189186700.1"
                     /transl_table=11
                     /translation="MTVAYVDAGEAVDQGRLSGKVAGGDVAPPVVAGVDYERILNAREE
                     PQNWLTYYGAYNGQRYSPLDQVNTENVKRIGPAWVFQAGTTGLIAGASTYSFEAAPIVV
                     DGVMFLSGWDGWVWALDAKTGVEIWRYKHAVPFDVSLCCGNVNRGVAVAQGKVFFVTAN
                     ARVLALDATTGKRVWDQTYGDVRAGESATLAPLVVKNKLIVGSSGGEFGVRGHLDAFDL
                     ETGEHQWRCYTVPKPGEPGSETWPADSEAWARGGANCWVTGTFDPETNLLYVGTGNPAP
                     DFDGGVREGDNLFTDSIIAVDVDSGQIRWHYQCTPHDVWDYDSIAECILFEQDGRKLLG
                     HFDKNGYFFVLDRTNGARVGITPFVDRISWGAITRDGQVTAKVYPDKEGEPVHFYPGPA
                     GAKEWTHAAYSPKTGLFYVPVQDTGATATRRRREFKESIPYWGAGVQVDIEDMAGSISA
                     FDANGEEKWRWRNELPMCASTLATGGDLVFAGEPSGEFNALDARTGELLWQFQCGSGHH
                     SSPTTYMVDGRQYIAVPVGWGAWAEGFLPGMLGAGHGSALIVFALPESS"
     gene            8902..8997
                     /gene="pqqA"
                     /locus_tag="IEY95_RS16015"
     CDS             8902..8997
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: protein motif:HMM:TIGR02107.1"
                     /locus_tag="IEY95_RS16015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_189186701.1"
                     /transl_table=11
                     /translation="MEYQLAVWETPEFVEIAVAAEVTMYLGRWED"
     gene            9106..9996
                     /gene="pqqB"
                     /locus_tag="IEY95_RS16020"
                     /old_locus_tag="GCM10011579_032470"
     CDS             9106..9996
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559515.1"
                     /locus_tag="IEY95_RS16020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032470"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_189186702.1"
                     /transl_table=11
                     /translation="MLLRVLGSAAGGGSPQWNCTCPVCAAVRSRAGLARTQSSVAVSAD
                     RRRWFLINASPDVRTQIEAFPGLHPHDDRTTPLEAVLLTDAELDHTLGLLLLREARALR
                     LYATPAVRKTLSADGSGILSTLERYCPVEWRAVIPGDELALADGLSCRAFDVPSSKRAR
                     FEAGLEHGRVVGYRLTDERSGGTLVYLPGVQSLTPALRVEIEDSECLLIDGTCWRDDEL
                     VRLGLAGRTSREMGHLPIEGQDGSLAQLPSLRVGRTIFVHMNNTNPILLEDAPERRILD
                     EKGMEVAMDGLEVQV"
     gene            10001..10699
                     /gene="pqqC"
                     /locus_tag="IEY95_RS16025"
                     /old_locus_tag="GCM10011579_032480"
     CDS             10001..10699
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671046.1"
                     /locus_tag="IEY95_RS16025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032480"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_189186703.1"
                     /sec_met_domain="TIGR02111 (E-value: 3.8e-101, bitscore:
                     332.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTITRTGTDGFVEALRAHSRRYHDQHPFHVRMNAGQLSREQIR
                     GWVANRFYYQENIPRKDAAILANCPDLEVRRRWIRRIVDHDGTAAGEGGIEAWLRLGEA
                     VGLTREEVRDHRHLVPGVRFAVDAYVNFARNRPWVEAVASSLTELFAPDLMAARLAGFE
                     RWYPWIDPEGLAYFRARLEQAPRDCEHALEVVTAYCRSAESQARAVDALSFKCDVLWSL
                     LDAIDQAYPE"
     gene            10705..11034
                     /gene="pqqD"
                     /locus_tag="IEY95_RS16030"
                     /old_locus_tag="GCM10011579_032490"
     CDS             10705..11034
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671045.1"
                     /locus_tag="IEY95_RS16030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032490"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_189186704.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.4e-23, bitscore:
                     76.2, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.4e-15, bitscore: 51.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPTRTGTTQTSTRTRHGVEVSGSDRPRLARHVRLDFCRTRQRPI
                     LLHPETVVVLNDSSAAILELCDGRRTVAEIVTELGSRYQTVPDDEVRQFLTQLVARRWV
                     ELTDG"
     aSDomain        10762..11022
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IEY95_RS16030_PqqD_RRE.1"
                     /evalue="1.90E-24"
                     /identifier="RREFam006.1"
                     /label="IEY95_RS16030"
                     /locus_tag="IEY95_RS16030"
                     /protein_end="106"
                     /protein_start="19"
                     /score="76.2"
                     /tool="antismash"
                     /translation="EVSGSDRPRLARHVRLDFCRTRQRPILLHPETVVVLNDSSAAILE
                     LCDGRRTVAEIVTELGSRYQTVPDDEVRQFLTQLVARRWVEL"
     gene            11027..12142
                     /gene="pqqE"
                     /locus_tag="IEY95_RS16035"
                     /old_locus_tag="GCM10011579_032500"
     CDS             11027..12142
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524877.1"
                     /locus_tag="IEY95_RS16035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032500"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_189186705.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.4e-31, bitscore:
                     104.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1e-23, bitscore: 79.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.8e-10, bitscore: 35.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6e-10, bitscore: 34.4,
                     seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSPFGLLAELTYRCPLACSYCSNPLNMGDYQDELATDEWLRVLA
                     EASDLGVLQCHLSGGEPLLRRDLVEIVAGAHGLGLYTNLVTSALGLSRPRAERLRAAGL
                     DHVQISIQAHEAALSDRIAGIPSFQRKIEAMGLVKELGWPLTMNVVLHRHNIDRVADVL
                     ELAEKVGADRVELANTQYYGWAWRNRDALLPTRAQLKAAEVVVRATRERLRERMDVVYV
                     IPDYYSRYPKPCMGGWASRQLTVTPNGDVLPCPAAQSLPLPRASVREDPLERIWAESPV
                     MTAFRGTDWMPEPCRSCPRRELDYGGCRCQAFLLTGDAARTDPVCHLSPDHDLVARAVE
                     AANADSRPDDLPLIPRPHRARRPTHLPGGAD"
     gene            complement(12139..12678)
                     /locus_tag="IEY95_RS16040"
                     /old_locus_tag="GCM10011579_032510"
     CDS             complement(12139..12678)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559519.1"
                     /locus_tag="IEY95_RS16040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032510"
                     /product="manganese efflux pump"
                     /protein_id="WP_189186706.1"
                     /transl_table=11
                     /translation="MIWEILVLGFVLSLDNFRVSIALGTVPFGLKRAVQVALTFGLWDA
                     IMPLVGLLIGRQIGESVGDVADLVGAAALGGYGLYLVFSALGNPEPDELDHPWALFGIP
                     LTLSLDNLFAGASLGIVGLSPWFSAAVFGLMTAALSLVGLRLGRAAARLVRIRSDLLSG
                     VTLIIAAAVLPLWSGG"
     misc_feature    12740..12756
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.61"
                     /tool="antismash"
     misc_feature    complement(12811..12825)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.16"
                     /tool="antismash"
     misc_feature    complement(12812..12826)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.23"
                     /tool="antismash"
     gene            complement(12861..13214)
                     /locus_tag="IEY95_RS49000"
                     /old_locus_tag="GCM10011579_032520"
     CDS             complement(12861..13214)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024412.5"
                     /locus_tag="IEY95_RS49000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032520"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_229703000.1"
                     /transl_table=11
                     /translation="MSCRYFGISRQAYYSWYCRYQAEGVEGVRTRSKAPKTSPNATHVE
                     VVGKTIYLRQNYHFGPEEIAAGGQRAGSRQLVWGRRKTRLVPTCRADGTPRPPHGHVRP
                     PAYGVRMTSGEPP"
     misc_feature    complement(13266..13281)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            complement(13398..13694)
                     /locus_tag="IEY95_RS16050"
                     /old_locus_tag="GCM10011579_032530"
     CDS             complement(13398..13694)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045569.1"
                     /locus_tag="IEY95_RS16050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032530"
                     /product="hypothetical protein"
                     /protein_id="WP_189186707.1"
                     /transl_table=11
                     /translation="MRVDGGGDAAPRAAAAEFADLSDNELLTREAELEQRRVTVRDERQ
                     RLFSERRNSKREKSRRGLFLPPLHDDDADSDALPRERPDAALAKSKKRRQQRP"
     gene            complement(14311..>14508)
                     /locus_tag="IEY95_RS16055"
     CDS             complement(14311..>14508)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY95_RS16055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189186708.1"
                     /transl_table=11
                     /translation="NGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGN
                     GNGNGNGNGNGNGNGNGNGN"
     assembly_gap    14509..14528
                     /estimated_length=20
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<14529..14851)
                     /locus_tag="IEY95_RS16060"
     CDS             complement(<14529..14851)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF046825.1"
                     /locus_tag="IEY95_RS16060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_189186709.1"
                     /transl_table=11
                     /translation="MNSSNKRRRFLMLAASTALAAGGVMLPATGAFAAAPTAQPHMVIA
                     HHAHQGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGNGN
                     GNG"
     misc_feature    complement(14948..14968)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.59"
                     /tool="antismash"
     misc_feature    complement(14987..15000)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            15938..16870
                     /locus_tag="IEY95_RS16065"
                     /old_locus_tag="GCM10011579_032560"
     CDS             15938..16870
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524132.1"
                     /locus_tag="IEY95_RS16065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032560"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_229703002.1"
                     /transl_table=11
                     /translation="MGNTGELSPYEAQDAAGFVASMQRLKVRSGLTYRELEERAALSGD
                     VLARSTLADVLQRSSLPRPEVVAAFVRACGQGHRVGDWLDARTRIASRIAAGTVTSSGS
                     EDGAESPPDAAEAVGVRSRPTAFRTTGFVAAVMVPLFALIAWGLLLDNPDTPGKRVVPA
                     TGWVTIRPSRTPDLCLTDGRDRAGAYANAVAVQLPCVQATVPRTYLEPAGEDLYRIQWH
                     HPQEGKGCLTVMSTGPVKGMLEPRNDCVHATLFHLVTAGTRNAGEYLIRPGNSSRCIGI
                     VDEDTAEGAEAVEERCTGGAGQRFLVREG"
     gene            17079..17534
                     /locus_tag="IEY95_RS16070"
                     /old_locus_tag="GCM10011579_032570"
     CDS             17079..17534
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY95_RS16070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011579_032570"
                     /product="hypothetical protein"
                     /protein_id="WP_189186710.1"
                     /transl_table=11
                     /translation="MTNQRTLIRIAGAAVAAFGAVVGLTGQAQAVSYELSWFRTANSSQ
                     GALAEGALLYPSSGCGYTKIKDPDNPYMNSVSDTDADGNGAIAYIGYIPCNSTTGHIVE
                     KKLASVAGEGNSAELPTTTYYNVRWAAVRVCEYRGTNQHIDCGGWAN"
     gene            complement(18085..18606)
                     /locus_tag="IEY95_RS16075"
                     /old_locus_tag="GCM10011579_032590"
     CDS             complement(18085..18606)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068254.1"
                     /locus_tag="IEY95_RS16075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032590"
                     /product="hypothetical protein"
                     /protein_id="WP_189186711.1"
                     /transl_table=11
                     /translation="MTMRGWIYRYVGPADLRSLVRPGGGGQMRSTADFGEWASARTAEE
                     LSEPFTFVVDQTGALRLAPRRSEHMVCAGGEAVLCAGEISFREESGRWAVNEVSNQSTG
                     YCPDVSSWPALAEALDQAGIVRPSGFTHEVVFRRCPACQQLNIVREQDFVCVFCDAVLP
                     PEWNVDRPGR"
     misc_feature    18596..18609
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.23"
                     /tool="antismash"
     misc_feature    18719..18732
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.36"
                     /tool="antismash"
     gene            complement(18952..19917)
                     /locus_tag="IEY95_RS16080"
                     /old_locus_tag="GCM10011579_032600"
     CDS             complement(18952..19917)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841693.1"
                     /locus_tag="IEY95_RS16080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032600"
                     /product="DUF6454 family protein"
                     /protein_id="WP_189186712.1"
                     /transl_table=11
                     /translation="MTRRMAVAAASLALVAGGVATAATAAPSRPAGGVASDFTAVTRGT
                     AWNLVGKLQLKFPTYHTEGIAFAGDLIFLSSVQILEPTVKYPVPQGRYDRSPGKGIGHV
                     FVIDRKGNLQKDIVLGEGDMYHPSGIDFDGTSVWVPVAEYRPNSAAIMYRIDAKTLEVH
                     KQFTVDDHIGGVVRDQATGHLVGQTWGSRRFVEWNLAGKQLASWDNPGHFIDYQDCQSL
                     PAHKMICGGITNLPQTPSAGGATATYELGGIGLLDVHTHELLHEVPFQQWSTAGHVATR
                     NPFKIKDDGNKLTMWVAPDNGDEGNGTEILTYQATVPATQ"
     misc_feature    19976..19991
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.13"
                     /tool="antismash"
     misc_feature    complement(19977..19990)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.0"
                     /tool="antismash"
     gene            20202..21170
                     /locus_tag="IEY95_RS16085"
                     /old_locus_tag="GCM10011579_032610"
     CDS             20202..21170
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY95_RS16085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011579_032610"
                     /product="hypothetical protein"
                     /protein_id="WP_189186713.1"
                     /transl_table=11
                     /translation="MRHLERYLVSRRETCSEKTARKNLQELLLLVKELPGQDRLHGALA
                     DYLGQHGHGADARSSGRPGYSDRELSAIVTAARSDVVAIRDRVAAGERPLERFLTDSAG
                     LPEAEREQGARLEVMARTGRVQVDYRRLSAGEYPAVCYATARQLFMVDEDLTPLMIYAA
                     VLSGRNLEKLKELPAEHRLLEGRAVAVTLTKRRRGKANSRTSVHWSVDDDPGRQLRTTG
                     GFYPLLHRMMARSRALSSRHRCGQSGRQRPRGRQKRVDQRAHRPVRHRTGPAATGSASG
                     RPATAWSATTRHSFICGSPRSGQRSKPARPRRSAVTCPPRG"
     misc_feature    21344..21358
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.79"
                     /tool="antismash"
     gene            21418..21858
                     /locus_tag="IEY95_RS16090"
                     /old_locus_tag="GCM10011579_032620"
     CDS             21418..21858
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005479003.1"
                     /locus_tag="IEY95_RS16090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_032620"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_189186714.1"
                     /transl_table=11
                     /translation="MDDIDRAILRELQVDGRIPYADLGPKVGLSPSAARLRLQRLIDTK
                     AVQVVGVTDPMTMGQQTMALLGLRIDGDPRAVADELSRHDEVVYTVLTAGGFDLFAEVV
                     CSQPRDLLDFINDVVRPVEGVASVENFPYFAIHTHRFLWHVD"
ORIGIN
        1 tctgctggtc cgagtgcgcg gccggcacaa acggcattgg gacggcgctc gaggcgcacg
       61 gcccggtacc gatcagtggc gcggagcact ggtgccaggc gtttcacgac tgggtctgcg
      121 cgggcatcgc ggtgcgtgac gtggtgacca gggaaccgat cgcggtcctg aacatcggct
      181 gctggcgcag ccaactcccc gcgtccgcgg aaagctggct ggcgaacacg gccaccatga
      241 cccagtaccc gctgaagagg cgcgcccggg attgcggcgc cgagttggtc gcggcctaca
      301 cccaggccag agcacattcc agtacggcgc tcgcggcggt ggacaccgca ggcaaggtgg
      361 tgatcgccga cgacatggca agcgtgctcc tgggcgtccc ggcaaacacc ccggcggtcc
      421 accccacgct gcgatggaac cccgggctgc cggaattgat tacagccgcc cggtatgcca
      481 cggggcaggc ggcccacaac cctgaatggg tcggctcgac gcagatcttc gcccacctcg
      541 ccgacgagcc gacatcgatc agcatccgac ccgtcttctc gtccgggcgt ctgatcggga
      601 acctgatctc gttcggtgcc tcggacgggg cacagttgcc cgagccggaa ggctccacgc
      661 accctcaggt tccgccgcgc cgcctggtcg cgacgcgcgg caaccggatg gtgctgctgc
      721 gtctgccgga agtctccttc gccgaatcgc agggaaacga cgtgtggcta tccaccgatc
      781 aggggcgatt gcgagccgcc tccccgagcc tggacaagct cgacagtgag ttggcggatg
      841 ccggcttcct gcgggtgcac cgcaggtatg tggtcaatct cagccgcatc cgggagatcg
      901 agcgcgggct caggggcgag ctgtctctgg tcatggatga tcggacgaag gagatggtgc
      961 cggtttcccg gcggaacgcg ccagccgtgc gtcgcgcgct ggacatctga gttcccttgc
     1021 acaacatccg tttctcggaa ggaacaattc ccgtgtctga cattccggac gccgttgtcg
     1081 gcgagacgaa cgtcgggagc gcgggcggcc tcggcctctc tgtatcggcc gggtaccgca
     1141 gtcacccgat ggggggcgcg agcaatcgcg actggtggcc gaaccggctc aacctgacga
     1201 tcctccggaa acacccctcc atggccgacc ccatgggcga ggacttcgac tatgccgcgg
     1261 agttccggac gctcgacctc gacgccctgg cgcgggacgt cgacggggtg ctgacgacgt
     1321 cgcaggagtg gtggccggcc gacttcggcc actacgggcc gctggtgatc cggatggtgt
     1381 ggcatggcgc cgggacgtac cgcatcgacg acggccgggg tggcgcgggc gccggcatgc
     1441 agcggttcgc gccgctgaac agctggccgg acaatcgcaa cctcgacaag gcgcgccggc
     1501 tgctgtggcc ggtgaagaag aagtacggcc gcaaggtctc ctgggccgac ctgatgatct
     1561 tcgccggcaa ccgcgccctg gagacgatgg gcttcaagac cttcggcttc gccggcggcc
     1621 gggcggacgg ctgggagccc gacgaggacg tctactgggg tcccgagcgg gcctggctcg
     1681 gcgacgaacg ccacggcggc gtccgggaac tggagaaccc tttggccgcc gtccagatgg
     1741 gcctcatcta cgtcaacccg gagggaccgc acaccgtccc ggacccgctc acggcggccc
     1801 gggacatccg cgagacgtcc cggcgcatgg ggatgaacga tgaggaaacc gtcgctctga
     1861 tcgcgggcgg ccactcgttc ggcaagaccc acggcgcggc cgacccggac gcccacctcg
     1921 gccccgaacc cgagggcgct cccctcgagg agcagggcct gggctggaag agcagctacg
     1981 gcaccggaaa gggcggggac accatctcca gcgggctcga gggcacgtgg acacccaccc
     2041 cgacgcgatg ggacaacagc ttcttcgaga ccctgttcgg ctacgagtgg gacctggagc
     2101 tgagccccgg cggtctatgg cagtggatcc cgagagacgg ccgcggagcg ggcacggttc
     2161 cggacgccca cgacccatcg acgacacacg ccccgacgat tctgacgacg gacctcgcgc
     2221 tgcggttgga cccggtctac gagccgatct cgcggcgctt cctggagaac ccggaccagt
     2281 tcgcggacgc gttcgcccgg gcgtggttca agctgacgca cctcgacatg ggcccgatcc
     2341 agcgctacct cggcccgctg gtccctcggg agaagctgat ctggcaggac ccgatccccg
     2401 ctgtggacca cccgctcgtc ggggcggcgg acatcgccgc actcaagaac cggatcctag
     2461 cctccgggct atcggtctcc cagctcgtct cgactgcgtg ggcgtcggcc tcgacgttcc
     2521 gcgtcagtga caagcgtggc ggggcaaacg gcgcgcgcat ccgcctcgag ccgcagcagg
     2581 gatgggaggt caaccagccc gacacgctgg cccaggtgct gcgcaccctg gaggggatcc
     2641 aggagtcctt caacagctcc cagaccggtg acaagaagat ctcgctggcc gacctcatcg
     2701 tgctcggcgg agccgccgcc gtcgagcagg ccgccaagac cgccggccac gatgtcgagg
     2761 tccccttcat tccgggacgc acggacgcca cgcaggagtg gaccgatgcg gagtccttcg
     2821 ccccgctcga gccgaccgct gacgggttcc gcaactaccg cggcaagggc aaccggctgc
     2881 cgtcggagca cctgctggtc gaccgcgcga acctgctgga cctcagcgcg cccgagatga
     2941 ccgtcctcgt gggtgggctg cgggtgctgg gcgccaacta ccggcagtca ccgctgggcg
     3001 tcttcacctc gttgcccggg tcgctgtcca acgacttctt cgtgaatctg ctcgacacgg
     3061 gcacggtatg gaagtcgaca tccgcgaccg cggaaacctt cgagggccgc gaccgcgtca
     3121 ccggcgaggt caaatggacc ggcagccgcg tcgacctcgt cttcggctcg aactccgagc
     3181 tgcgtgccat cgccgaggtg tacgcgagcg acgacgcgga ggagaagttc gtgcaggact
     3241 ttgtcgccgc gtgggacaag gtcatgaacc tcgatcggta cgacctcgct tgagccccca
     3301 tcggggcccg gatgccggga gaggcgtcct gacggccagg ccgtattgat cgggtccgct
     3361 gccggcccca gcatgacgtg gtgcggtgca acccggatcc tcctaacccg ctgctttcac
     3421 gtgagtgcct gatggcggcg gtctgggggt cgagtgccgc ggagagtggg ttaccggttg
     3481 tgggcatggc ggcctggccg actggcgctg ccgggctgcg ggtctcccgg ttcctcgggt
     3541 cccggtaccg gaacgctgcg atttcgcagc gggcgagctc gaccacgtcg gcgaagcaga
     3601 tctgtttggt ccagcagatc aggtcgaccg cggtgagtac ggactcgagc caggcttggt
     3661 tctcgttgag ctcccggcag ggcaggttcc gcaggccggt ggccttggct tcgcggatcc
     3721 ggtcctcgac ccgggcgtgt tggcggtgcc gcaactccag cccggcagct tggaacggca
     3781 cgacaccggc gggggtgttg gtgagcaggg cggtgaccct cttgccgtcg atgtcggtga
     3841 aggtgagctg cgcgccggga tgggggcgtt ccttgcacag gatcagccgc gacccgtccg
     3901 gccacgagga gaggtcgatc atgccggtgg cctcggccac ccacgccccg tcacggaact
     3961 cgccatcagt tcggggtgcc agcagtcctc ggggatggcg tcgacgatgc cctggatccg
     4021 ggcgtccacg gagaacccga aggaaaactc cacgccacgc tccacgcacg cgacagcgaa
     4081 cgcgtgggtg gcgccggtcg agtccgaccg ggccagcagc cgcggacccg ccgggtctcc
     4141 gggctgaggc cgggcctgtt cgggcaacgc cgccagcatg ggcaacgacc acacatgggt
     4201 gtcgaatggc cggtgccccg ggatcctccc ggccccttcc tggcgattcc agcaggcgga
     4261 ctccccatcc cagcaggaac tatccgcgtc accaaccgcg tgggtgctcc ttcgtgtacg
     4321 ccgtgcggct accgctcgtg gacggtgtag gtcaggtggg tcacccgctg cgtcggctcc
     4381 gcgcggacct gctccagggc cacgcggccc gcgtccacgc cctcgaacag gcggattccg
     4441 gagccgaaca gcacgggtga gagcgcgatc gagaactcgt cgatcaggcc ggcgttcacg
     4501 tactccagga tcgttgcgcc gccgcccgcg atgcggacgt cccggtcgcc ggcggcctcg
     4561 cgggcctggt cgagcgcggg ctcgatgccg tcgttgacga agtggaaggt ggtcccgccc
     4621 ggccgctccc aggggtcacg cttctcgtgc gtcacgacga acaccggcgt gtggaacggc
     4681 gcctcctccg gccacgcctg ctggccgagg tcgaacatgc gcttgcccat cacgctcgcg
     4741 ccggtgcgct cgaacgtctc ccgcacgatg tcgttgtcgc gcccttcctc gccgccctcg
     4801 ccgagcttca ggttctcccg gaagaaccgc tgcgggaaga tccactgctg cagttccatc
     4861 cactgcgcca tccagcgctg gacctgcggg tcgtcctgct tctcgggcgc gaagaagccc
     4921 tcaacgggca cggactcggg cgcgatgaac ccgtccagcg acatcgacac gctgaagaac
     4981 accttcccgg ccatcagccc tccgctccct ttcgaacgat ctcggtgacg taggcagcca
     5041 ggttgctcag ggtctgctgg ccgccctcga tcgcgtggta cttctcgacc gcctcgtcgc
     5101 gcagctcctt ggtggggaac accgtgcgca tctcgatccg ggtctccgcg ccgtcgggcg
     5161 cgaacgtgag gaccgactcg aaggtgttcg ggtcgccgcg ggactcaccg tggagcagcg
     5221 cgatccgctc cggcggggcg atctcggtcc aggagatcca ctcctggtag tccgtcccgt
     5281 ccggtccgtg catcacgaag tcccactccc cgccgacgcg gaactcgaac gcccgcgtgg
     5341 tggtggtgaa cccctccggt ccccaccacc gcgacaggtg ccgcacctcg gtgaacgcct
     5401 cgaacaccag ctcccgtggg gcgtcgatga cccgggagat cacgatctcg cggtcggccg
     5461 tcccggactg cgccggcgct cctcgtcccg tcgcgctcat tagctactcc tcctgccttg
     5521 cctgcttgag gtcctgcacg tacgcgtcca gccggtcgaa gctctcgttc cagaaccgct
     5581 cgaacccgcc ggtccactcg tgaaccggtc gcagcccgcg ggcgtcaagg ccgtacaggc
     5641 gttgcttgcc tgccttgcgg tcccgcacca gtccgacctc ccggagcacc cgcaggtgtt
     5701 tggacgcccc cggctgggtc atccccagct cctgggccaa ctcggtcacc ggccgctctc
     5761 ccgcccgcag cagcaccagg agctcccggc gctgcggctc ggcgatcgcg ttgaagacgt
     5821 ccgacgtcgt cgctgctcgt gccatggcgc gatcatattc ctatatcggc atacgtcaag
     5881 ccgggaggaa tcaggcgggt cttgtcagat gacgatggtg acccttgtca gcggctgcgg
     5941 aaacgcgtat cccggagacg gcacgcgcga cggcggcggg cagggagggc gatgggtgag
     6001 cagcacgccc acggctggcg ggtgagccgc caccggctgg tggccgacgc cacggtcggc
     6061 gtcatcgcca acccgatgtc gggccgtgac atccggcggc tcgtcgcgag cacgtccgtg
     6121 ttccccaacg ccgagaaggc cagcatggtg gtccggctga cggccgccgc gggggcactc
     6181 ggggtgggct ctactgccac cgcgagatcg gtgaacaccc gccccggcgc atgagtcggc
     6241 acacccttgt aggtgccgat caaagttcga acagcccaag aatcccaagc aggacaggca
     6301 cttccgtgct tctacaggcc gatcagccca gactgacgtg aacgacccgg gctaacggtg
     6361 gcacatcggg tgcgaacggc ggctgatcgc ggacgaacgg catgagctgg cccgaagtgg
     6421 cgctcagcct tgtcgggcgt agcgtgtttt ttgaccacca atttcccccc ttttcggtgt
     6481 gattcattcc ggcgtgtcgc cactctttgg ccaccggttg cagggggcag cgggcaacgc
     6541 aaaagaattt cgaggtcaat tcggagaaca ttttcgccga gcagaggtgc gcaagcgacc
     6601 gctatgcgcc gccgtcaacg cagccgatgc gaggtggaca gcaattcggg atgaggagag
     6661 tgaagcccga tgacgaccgc tcaggagcga tccgacctgc tggaccagat cgggttggcc
     6721 gcacagaaca aggcaacgct gggtcaagtg ctgggcaccg gacgcattgg gcaggccacc
     6781 gagaaatcgg atggccgcat gcaggccacc attcgcatcc acccggatga gctgacctgg
     6841 gatcccgaca ttctggtcat gccccatgga ggcgatatcg acctcgagct cgtcaatgac
     6901 gacctgaaca cgcactgcgc gctcctgccg agcaatggcg accgcaagtt catctggttg
     6961 gtaaaccatt cgcgaggtcg ggcgaccctc aacctcgacg gtccgggcta ctactggttc
     7021 ggctcgccta cgggcaatga cgagggccgg gggctgaccg gggccatcgt tgtcctgggg
     7081 gatgctccgc cggaggctcg cctcgaccgt cccgaacagc cgcggccgta agaagaagca
     7141 ggaggtaaag aaaatgaccg tcgcctacgt ggacgcgggt gaggctgtcg atcagggccg
     7201 cctgagcggc aaggtagcgg gcggggacgt cgcgccgcct gtagtggccg gcgtcgacta
     7261 cgagcgcata ctcaatgccc gtgaggaacc ccagaactgg ctcacctact acggcgccta
     7321 caacgggcag cggtacagcc cgctggatca ggtcaacacg gagaacgtca agcgcatcgg
     7381 ccccgcatgg gtcttccagg ccggcacgac cggcctgatc gcgggggcgt cgacctactc
     7441 gttcgaggcc gccccgatcg tcgtcgacgg ggtcatgttc ctctccggct gggacggctg
     7501 ggtctgggcc ctggacgcga agacgggcgt ggagatctgg cggtacaagc atgcggtccc
     7561 cttcgacgtg tccttgtgct gcggaaacgt gaaccgtggg gtcgccgtgg ctcaggggaa
     7621 ggtcttcttc gtcacggcga atgctcgtgt gctcgcgctc gacgccacca ccggcaagcg
     7681 ggtctgggac cagacctacg gagacgtccg ggccggggag agcgccacgc tcgcaccgct
     7741 ggtcgtgaag aacaagctca tcgtcgggag ctccggcggc gagttcggcg tacgcggtca
     7801 cctcgacgca ttcgacctcg agaccggcga gcaccagtgg cggtgctaca cggtgccaaa
     7861 gcccggggag cccggctcgg agacctggcc agccgacagc gaggcctggg cacggggtgg
     7921 ggcgaactgc tgggtcaccg gcacctttga cccggagacg aacctgctgt acgtcgggac
     7981 cggtaacccg gcacccgact tcgacggcgg cgtccgcgag ggcgacaacc tcttcaccga
     8041 cagcatcatc gccgtcgacg tggacagcgg tcagatccgc tggcactacc agtgcactcc
     8101 gcacgacgtt tgggactacg acagcatcgc cgagtgcatc ctgttcgagc aggacgggcg
     8161 caaactgctc gggcacttcg acaagaacgg ctacttcttc gtccttgacc gcacgaacgg
     8221 cgcgagggtc gggatcaccc ccttcgtgga ccgcatctcg tggggggcga tcacgaggga
     8281 cggccaggtg acggccaagg tgtacccgga caaggaggga gaaccggtcc acttctaccc
     8341 gggtccggcc ggcgccaagg aatggaccca tgcggcctac agcccgaaga ccgggctctt
     8401 ctacgtcccg gtccaggaca ccggcgcgac ggccacccgg cggcgccggg agttcaagga
     8461 gagcattccg tactggggcg cgggcgttca ggtggacatc gaggacatgg cggggtccat
     8521 cagcgccttc gacgcgaacg gcgaggagaa gtggcgctgg cgcaacgaac tcccgatgtg
     8581 cgcctcgacg ctggccaccg gcggtgacct ggtgttcgcc ggtgaaccct ctggggagtt
     8641 caacgcgctc gacgcccgca ctggggaact gctgtggcag ttccagtgcg gaagcggcca
     8701 ccacagcagc ccgacgacct acatggtcga cggcaggcag tacatcgcag tgccggtcgg
     8761 ttggggcgcg tgggctgagg gattcctccc cggcatgctc ggcgcggggc acggtagcgc
     8821 tctgatcgtc ttcgccctcc cggaatcgtc gtagcgcgtg accggagcct gccgtgaccc
     8881 gggcagagag gaggtgaacc catggagtat cagctggctg tgtgggagac gcccgagttt
     8941 gtcgagatcg cagtcgcggc cgaggtgacc atgtacctcg gtcggtggga ggactagcgg
     9001 acgtggggcg gcgccggacc tggtccggcg ccctccgacg cctggggacg gccacggacc
     9061 gccgggttgg cgacggcccg gatcgtcgat gaacggagtg ccgacgtgtt gctgcgagtc
     9121 ctgggctcgg cggcgggggg cgggtccccg cagtggaact gcacctgccc ggtgtgtgcc
     9181 gcggttcgct cccgggccgg cctcgcgcgc acccagtcgt cggtcgcggt cagcgctgac
     9241 cgccgccggt ggttcctcat caacgcctcg cccgacgtcc gcacacagat cgaggccttc
     9301 cccggcctgc acccgcacga cgaccggacg acgccgctgg aggcggtgct gctcaccgac
     9361 gccgagctgg accacacgct gggcctgctt ctgttgcggg aggcccgcgc cctgcggctg
     9421 tacgccacgc cggcggtgcg caagaccctg agtgccgacg gctcggggat tctgagcacg
     9481 ctcgagcgct actgtccggt cgagtggcga gcagtgatcc cgggcgacga actcgccttg
     9541 gccgacgggc tgtcctgccg ggcgttcgac gttcccagca gcaagcgcgc tcgcttcgaa
     9601 gccgggctgg aacacggccg cgtcgtgggc taccggctga ccgacgagcg cagcgggggc
     9661 acgctggtgt acctgccagg ggtgcaatcg ctgacgccgg cgctgcgcgt ggagatcgag
     9721 gacagcgaat gcctgctgat cgacgggacc tgctggcgcg acgacgaact cgtacggctg
     9781 ggcctggccg gcagaacgtc ccgggagatg ggccacctgc ccatcgaggg ccaggacggc
     9841 agcctggcgc agctcccgtc gctgcgcgtg ggacggacga tcttcgtgca catgaacaac
     9901 accaacccca tcctcctgga ggacgcgcct gagcggcgca tcttggacga gaagggcatg
     9961 gaggtggcca tggacggcct cgaggtccag gtgtagggcc atgacgacaa ccatcacgag
    10021 aaccggcacc gacggcttcg tcgaggcgtt gcgggcccac tcgcggcggt accacgacca
    10081 gcacccgttc cacgtccgga tgaacgccgg ccagctgagc cgcgagcaga tacggggctg
    10141 ggtggccaac cgcttctact accaggagaa catcccccgc aaggacgccg cgatcctcgc
    10201 caactgcccc gaccttgagg tccgccgccg ttggatccga cggatcgtcg accatgacgg
    10261 caccgccgcc ggcgagggcg gcatcgaggc gtggctgcgc ctcggcgagg ccgtcgggct
    10321 gacccgcgag gaggtccggg accaccggca cctggtaccc ggcgtgcggt tcgccgtcga
    10381 tgcctacgtg aacttcgccc ggaaccgccc gtgggtggaa gcggtcgcgt cctcgctcac
    10441 cgagctgttc gcccccgacc tgatggcggc gcggctggcc gggttcgagc ggtggtaccc
    10501 gtggatcgac cccgagggcc tcgcttactt ccgcgcccgc cttgagcagg ctccccgcga
    10561 ctgcgagcac gcactcgagg tggtcaccgc gtactgccgc tccgccgagt cccaggcgcg
    10621 cgccgtcgac gcgctgtcgt tcaagtgcga cgtcctgtgg agcctgctgg acgccatcga
    10681 ccaggcctac ccggagtgac catcatggac ccgacccgta ctggaacgac ccagaccagc
    10741 actaggaccc ggcacggcgt cgaggtgtcc ggctcggacc ggccccggtt ggcgcgccat
    10801 gtccggttgg acttctgccg gaccaggcag cgtccgatcc tgctgcaccc cgagacggtg
    10861 gtggttctga acgacagcag cgcggccatc ctcgaactgt gcgacgggcg gcgcaccgtg
    10921 gccgagatcg tgaccgagct gggcagccgc taccagaccg tccccgacga cgaggtgcgg
    10981 cagttcctca cccagctcgt cgcccggcgc tgggtggagc tcaccgatgg atagcccgtt
    11041 cgggctgctc gccgagctca cctaccgctg cccgctggcc tgctcatact gctccaaccc
    11101 gctgaacatg ggcgactacc aggacgagtt ggccaccgac gagtggctgc gggtgctggc
    11161 cgaggcaagc gacctggggg ttctgcagtg ccacctgtcg ggcggggaac cgctgctgcg
    11221 gcgcgacctg gtggagatcg tggctggcgc ccacggcctg ggcctctaca ccaacctcgt
    11281 gaccagcgcc ctcgggctct cgcgtccgag ggccgagcgg ctgcgggcag caggcctgga
    11341 ccacgtgcag atcagcatcc aggcccacga ggcggccctg tccgaccgga tcgctgggat
    11401 cccgtccttc cagcgcaaga tcgaggcgat gggcctggtc aaggagctgg gctggccact
    11461 caccatgaac gtggtgctgc accggcacaa catcgaccgc gtcgccgacg tgctcgagct
    11521 ggctgaaaag gtgggcgccg accgggtgga gctggccaac acccagtact acggctgggc
    11581 ctggcgaaac cgtgacgcgc tgctgccgac ccgggcccag ctcaaggcgg ccgaggtcgt
    11641 cgtgcgggcc acccgcgagc ggttgcgcga acgcatggac gtcgtctacg tcatccccga
    11701 ctactacagc cgctacccga agccctgcat gggcggctgg gcctcccggc agctgaccgt
    11761 gacgccgaac ggcgacgtcc tgccctgccc ggccgcccag tccctgccgt tgccgcgggc
    11821 cagcgtgcgg gaagacccgc tagagcggat ctgggcggag tcgccggtga tgaccgcgtt
    11881 ccgggggacg gactggatgc cggagccctg ccggagctgc ccccggcggg agttggacta
    11941 cggcgggtgc cgctgccagg cgttcctgct caccggtgac gccgcccgca ccgacccggt
    12001 ctgccacctg tcgcccgacc acgacctggt cgcccgggcg gtcgaggccg ccaacgccga
    12061 ctcgcgaccc gacgatcttc cgctgatacc gcgcccgcac cgggctcgcc ggccgaccca
    12121 cctcccgggt ggagcggact aaccgccaga ccacaacggc agcaccgcag cggcgatgat
    12181 caacgtgacc ccgctcagca ggtccgagcg gatccggacg aggcgcgctg cagcccgccc
    12241 gagccgcagc ccgaccagcg acaacgccgc cgtcatgagg ccgaagacgg cggcagagaa
    12301 ccacggcgag aggccaacga tccccaggct cgccccagcg aacaggttgt ccaggctcag
    12361 cgtcaacggg atgccgaaca gcgcccacgg gtggtccaac tcgtccggct cggggttccc
    12421 cagggccgag aagacgaggt aaagaccgta cccgccgagc gcggccgcgc ccaccaaatc
    12481 ggcgacgtcc ccgacggact caccgatctg gcgaccgatc aacagcccga ccaggggcat
    12541 aatcgcgtcc cacagcccaa acgtcagcgc gacctgcacc gcacgcttca gaccaaatgg
    12601 gacggtgccg agcgcgatcg atacccggaa attgtcgaga ctgagtacga agcccaggac
    12661 cagtatttcc cagatcatga cgacgtcgct gcccgatgag gaccgacgtc ggcaggaacg
    12721 actccatatc ggctagcatt cgccataatc aaacattata tctcagaggt cgctatatcg
    12781 cagatggtcc acgaaataga cccggtaaac tgatttctgg aaaattctcg acgctgagcc
    12841 ttttccaacc ttccctgtgg tcagggaggt tcgcctgacg tcatccggac accgtacgct
    12901 ggaggccgga cgtgtccgtg aggaggcctc ggagtaccgt ctgcacgaca agtaggaacg
    12961 agccgcgtct tcctgcggcc ccataccagt tgcctggatc cagcacgctg accgcccgcc
    13021 gcgatctcct ccgggccgaa gtggtagttc tgccggagat agatggtctt cccgaccacc
    13081 tcgacatgag tcgcgttcgg ggacgtcttc ggcgccttgg aacgggtgcg cacgccctcg
    13141 acgccctcgg cctggtagcg gcagtaccag ctgtagtacg cctgccggct gatcccgaag
    13201 tagcggcaag acatggcgac gtttccgtgt cctcttcgac gtggcgtatc accgccaggc
    13261 gccgcttggc ctcacggtca agcggcgggg tggtgggagt ggacttcgac atgaggatct
    13321 ccgtagtgat cagagaccca ggtgtcaacg atgatcgtca gttttggaat ccgctgaccg
    13381 agctgcctga ctcacggtca ggggcgctgc tgccgtcgct tcttcgactt ggcaagtgcg
    13441 gcatccggcc tctcgcgcgg caacgcgtcc gagtcggcgt cgtcgtcatg gagaggcggc
    13501 aggaacaggc cgcgtcggct tttctctcgt tttgaattcc ggcgctcgct gaagagccgc
    13561 tgacgctcgt cgcggaccgt gacccgccgc tgctccagct cggcttcccg tgtcagcagc
    13621 tcgttatcgc tgaggtcggc gaactcggcg gcagccgcac ggggcgcggc gtcaccgcca
    13681 ccatctacgc gcatgtgagg ctccacctcc agcaagacgc catcaacacc ctcggcaccg
    13741 cactcacaga cagccgaggg cacgcccagc ggtagcggcc gacggcgacg agtcgtcgcc
    13801 tcggacacct ctgtccgctg acgttgccgt cacctattgc cgtcacccca cgctgaaacc
    13861 ccgccagcgg ctggctgggc ttcaactttc ctgtggcgac ttgatcagtc agacccagcg
    13921 gaaccgctct tcgacagtcc acatcactcc ctaatcaatc cgcccacctc aagggcctag
    13981 gggttgacgg aaggtcaacc tcagaccttc gaaatgtgct tcgccacaag ccaggatgac
    14041 gcggaacctc cccgcctcaa ccccttcggg gtgcttcaca tatgaccatc tcttgccagt
    14101 ctcaacgaga agcgcccagg cccaccaccc ctgcccccat tcggcgcacg caacaccgca
    14161 ccgaaggctc acaccacaca ccgcttcacc gtgccgggcc gcgcacaaca gcccgtacca
    14221 cccgcccgca gacacgcgcc catggccggg cggcacgaac atgccacccg gccaaagacg
    14281 cggtccgcaa cattctttcc ctgtcagacc ttagtttccg ttgccgttcc cgttgccgtt
    14341 cccgttcccg ttgccgttcc cgttcccgtt gccgttcccg ttcccgttgc cgttgccgtt
    14401 cccgttcccg ttgccgttcc cgttgccgtt gccgttcccg ttgccgttgc cgttcccgtt
    14461 cccgttcccg ttgccgttcc cgttgccgtt gccgttcccg ttcccgttnn nnnnnnnnnn
    14521 nnnnnnnntt cccgttcccg ttcccgttgc cgttgccgtt gccgttcccg ttgccgttgc
    14581 cgttgccgtt cccgttgccg ttcccgttcc cgttgccgtt cccgttcccg ttcccgttgc
    14641 cgttcccgtt gccgttcccg ttcccgttcc cgttcccgtt cccgttcccg ttgccattgc
    14701 cctggtgggc gtggtgggct atgaccatgt gcggctgcgc cgtcggggca gcggcgaagg
    14761 cgccggtggc gggcagcatc acaccgcccg cggccagagc ggtcgaggcg gcaagcatca
    14821 ggaaacgacg gcgcttattg ctggaattca tggagtttct cctccggtga gaaatgatga
    14881 aaggggctgt cgaacgaccc cgaccgacgc gcgggccgtt ctccggcggg acacatatcc
    14941 cgcacaacac atcgccagcg ctttacccga caatgcggtg ggccacctga tctgcgtgaa
    15001 cccatgcctc cattagcacc cggcaagaaa aacccgtcac gcccctacat ctcgggactt
    15061 gacaaaagga gagaatgccg ataaccggca cgaacacccg gcaccacgac aacacatcac
    15121 cgccggacag cacaccggca caaacgaaga agcacccacg ccccacgcca ccgcccccac
    15181 cccgggcacc cgcagcaccc acccgtcccg gcccgcccat cacctgccag acccacccgg
    15241 tcaccgaccc gcaccacacc ccccacccgg gatctccagc gcccctacac acgacagcat
    15301 cgaagcggaa gccgcacaca cccggcattg ggcccatccg cccccgccgc ccgggacgcc
    15361 gcctgcagac aaccggccac accagcaacc ggcccgcacc accgtcaccg cccacacggc
    15421 atccacccac cagaccaccc ccgccacagc gccgggcccg cacggcgccc cggccggggc
    15481 gccggccggc accagcgggt ggccgccccc acacgtcccg gccggacgga taccaccgcc
    15541 cattcgcctg gagcggcacc gtctccacaa ccgcgacggc gtccgcgaca cctaccagtc
    15601 catggccgac gtcctggccc agctgacctg aacggccccg gacgcggtcc tgtctgtagg
    15661 gtccgcgact tcgttggcaa tgaaggcagt tcgttagcag tggattagca aatccgcgat
    15721 cccgttgaca atgactacgt tcagtagcga tccccttcga agctctttcg atagcgagtc
    15781 cgagatccac ggcggcgagc gcgaacaggc cctcgtggcg ttgggcgtgg acgtggagct
    15841 gtacctggag gcagggggaa tcctgcggat ctcgccgagg tcggatggcg ggaacctccg
    15901 ttgacctccc tgtcatggcc accacaggat ggaagtcatg ggaaacacgg gggagttgtc
    15961 gccgtacgag gcccaggacg ctgctggctt tgtcgcgtcg atgcagaggc tcaaggtgcg
    16021 ctcggggctg acctaccgcg agctggagga acgggccgcg ctgagcggtg acgtgctggc
    16081 gcgcagcacg cttgccgacg tcctacagcg gtccagcctg ccgcggcccg aagtggttgc
    16141 cgcgttcgtc cgcgcctgcg ggcaggggca ccgggtcggt gactggctgg atgcccggac
    16201 acggatcgcc tcccgcatcg ccgctgggac agtcacgtca tccgggtccg aggacggggc
    16261 cgagagccca ccggacgccg cggaagccgt gggtgtgcgg tcacgtccga cggcgttccg
    16321 tacgaccggc ttcgtggccg cggtcatggt cccgctgttc gccctgatcg cctgggggct
    16381 gctcctcgac aaccccgaca ccccggggaa acgggttgtc cctgccaccg ggtgggtcac
    16441 gatccgtccc tcccgtacac ccgacctctg cctgaccgac ggacgcgacc gcgccggcgc
    16501 ctatgcgaac gcggtcgcgg tccaacttcc ctgcgtccag gccaccgtgc cccgcaccta
    16561 cctcgaaccg gctggcgaag acctgtaccg catccagtgg caccaccccc aggagggaaa
    16621 gggctgcctg acggtcatga gcaccggccc ggtcaaaggc atgctggaac cccggaacga
    16681 ctgcgtccac gccactctgt tccacctggt caccgccggc acccgaaacg cgggcgagta
    16741 cctgatccgc ccgggcaaca gcagccggtg cattggaatc gtcgacgagg acaccgcaga
    16801 aggggcggaa gccgtcgagg aacggtgcac gggcggtgcc ggtcaacggt tcctcgtgcg
    16861 ggagggctga gaaccgggca atggagtaca ggttgtcccg gacgagcctc tgaccaggcc
    16921 ggacagtcgt ccgttgtccg ggacagccga cagctcttgt ctcaccctca atcctctcag
    16981 cagcatcggt actgcccgat cgggcacaac cattcaccac cggggcgggg ttgtagggcg
    17041 gctgcggttg ctcgtcccgc caccgagaag aggtagacat gaccaatcag cgaaccctta
    17101 tacgcatcgc cggagccgct gtggccgctt tcggcgccgt ggtggggctt actgggcagg
    17161 cacaggctgt gagttacgag ctgtcctggt ttcgtacggc aaattcgagc cagggggcac
    17221 tggcggaggg cgccctcctg tacccgagct cggggtgcgg ctacacgaag atcaaggacc
    17281 ccgacaatcc ctacatgaac tcggtcagcg acaccgacgc ggacgggaac ggcgcgatcg
    17341 cctacatcgg ctacatcccg tgcaacagca ccacgggaca tatcgtcgag aagaagctgg
    17401 ccagtgtcgc aggcgaaggc aacagcgcag aacttcccac gaccacctac tacaacgtca
    17461 ggtgggccgc cgtgcgggta tgcgagtaca gggggacgaa tcagcacatc gactgcggcg
    17521 gctgggcaaa ctgacggccg tcatcagcgg tcgacctgcg gcagttccgg cccgtgccgc
    17581 cagtccggcg gcacgggccc ctcagatcgt ctcgctgtag cggctccggc cttctccgtc
    17641 accgcaacat cactcgaaag gaaagcaacg cgtctacgtc atcccctcgc cggtgccgcg
    17701 atcggggtcc tgcccatcgc cggtgccgcg accgcgcctg cgagcgccgc ccacgctgag
    17761 cccctccatg cggcagccag cgactgggtc cccaaccagt ggaaccaggg cagccccgga
    17821 gcccgcacca cggccaacgc cgtctcccac gacggcccat acagcaagtg ctccggcgac
    17881 agcatcggcg ctcgctggat caccccgaac tgtgtctaca agaactcctt cgaccgctct
    17941 ttgccgactc ttgtcggcgg tcacgcaatt ccccagtctc ggccgcttca gcgtcacgta
    18001 attccccacc cgcgcggtca cgattcccca tggggacggc ggactcggac gcagccccaa
    18061 ggacccgacc ggtgagccaa gcgcctagcg tccgggccgg tccacgttcc actccggcgg
    18121 caggacggcg tcgcagaaga cgcagacgaa gtcctgctct cgcacgatat tgagctgctg
    18181 gcaggcgggg cagcgtcgga acaccacctc atgcgtgaag ccggacgggc gaacgatccc
    18241 ggcctggtcc agggcctcgg cgagggccgg ccacgagctg acgtccgggc aatagccggt
    18301 cgactggttg ctcacctcgt tgaccgccca ccgcccggac tcctcgcgga aactgatctc
    18361 accggcgcac aggaccgctt ccccaccagc acacaccatg tgctcactgc ggcgcggcgc
    18421 aagccgcagg gccccggtct gatcgacaac gaaggtgaag ggctcggaca actcctctgc
    18481 tgtccgagct gaagcccact cgccgaagtc tgccgtcgaa cgcatctgac caccgccgcc
    18541 cggtcggacg agactcctca agtcggccgg accgacataa cgatagatcc acccccgcat
    18601 ggtcatgctc gccaacctag acgagcaccg aggcgaggac ctggggaatt acgtgaccgc
    18661 agggatcggg aattacgtga ccgtcgacag ctctgtacgt cacggctgcg acaccacgtc
    18721 gaccgcgtcc aatggtcatc gccggcgggc cggacagccg gcgcgtgttc ggcggtgctg
    18781 cgggtgctcg cgccgcggtg ggttcccagt caggatgcct gccgcatcag aaggggccct
    18841 ggaggtagct ggatgccctt ctgtggccct gccgtgtgca ggcccccggg cggtgccgac
    18901 cggaggcctg cgtgctgtgc gggaggggca gggcagcagg tcgaggtcgg cttactgtgt
    18961 cgccggcact gtcgcctggt atgtgaggat ctccgtcccg ttgccctcgt cgccgttgtc
    19021 cggtgctacc cacatggtca gcttgtttcc gtcgtccttg atcttgaagg ggttgcgggt
    19081 ggccacgtgg ccggccgtgg accactgctg gaagggcacc tcgtgcaaca gctcgtgagt
    19141 gtgcacgtcg agcaggccga tgccgccgag ttcgtacgtg gcggtggcac cgccggcgga
    19201 gggggtctgg gggaggttgg tgatgccgcc gcagatcatc ttgtgggcgg gcaagctctg
    19261 gcagtcctgg tagtcgatga agtggccggg gttgtcccag gaggcgagct gcttgccggc
    19321 caggttccac tcgacgaagc ggcgggagcc ccaggtctgg ccgacgaggt ggccggtggc
    19381 ctggtcgcgg acgacaccgc cgatgtggtc gtcgaccgtg aactgcttat ggacctccag
    19441 ggtcttcgcg tcgatgcggt acatgatggc cgcgctgttg ggccggtact cggcgaccgg
    19501 cacccacacc gaggtgccgt cgaagtcgat gccggagggg tggtacatgt cgccctcacc
    19561 aaggacgatg tccttctgca ggttcccctt gcggtcgatc acgaagacgt ggccgatgcc
    19621 cttgcccggc gagcggtcgt aacgcccctg cgggacgggg tacttgactg tcggctcgag
    19681 gatctgcacg gaggacagga agatgaggtc gccggcgaaa gcgatgccct ccgtgtggta
    19741 cgtcgggaac ttcagctgga gcttgccgac cagattccag gcggtgccac gggtcaccgc
    19801 ggtgaagtcg gaggccacgc cgccggcagg cctgctcgga gcggcggtgg cggcggtcgc
    19861 cacgcccccg gccacgagcg ccagggatgc ggccgcgaca gccatgcgtc gggtcattgg
    19921 gatgttcgtg atcttcacga tgaacctctt gctgtggttg tgcccccggg acccggcgaa
    19981 tctatgttcg ggccgtgaat gccctatgac gtgaactgca atggtcgccg aaccgcgcgt
    20041 tgcaacgcct ctccacggag atcggactga gcacaccact tcgcctcatc gcaggggacc
    20101 gccgaatctc aggccaccga ctgaattcga taccgcgcga gccgcctttc agcaggtcag
    20161 cacattccat cggtgcctcg aagtgagcga ggcccgtaag ggtgcggcac ctggagcggt
    20221 acctggtgtc gcgccgggag acgtgcagtg agaagaccgc ccgtaagaat ttgcaggaac
    20281 tgctgctgct cgtgaaggag ttgcccggcc aggaccgtct tcacggcgcc ctggcggact
    20341 atctcggcca gcacggtcac ggggcggatg cccggtcgag cggccgaccc ggctactccg
    20401 atcgcgagct gtcggccatc gtcaccgcag cccgctcgga cgtggtggcc atccgcgacc
    20461 gagtcgccgc cggcgagcgg ccgctggagc ggttcctcac cgattccgca ggcctgcccg
    20521 aggccgaacg ggagcagggc gcccggcttg aggtgatggc ccgtaccggc cgggtccagg
    20581 tcgactaccg acggctgtca gcgggcgagt acccggcggt ctgctacgcg acggcccggc
    20641 agctgttcat ggtcgacgag gatctcaccc cgctgatgat ctacgcggcg gtgctgtccg
    20701 gccggaacct ggagaagctg aaggagctgc ccgccgagca ccgtctcctg gagggccggg
    20761 cggtggcggt gaccctgacc aagcgccggc ggggcaaggc caactcgcgt accagcgtgc
    20821 actggagcgt ggacgacgat ccaggccgcc agctgaggac gaccggcggc ttctacccgc
    20881 tgttgcaccg gatgatggcg cgcagccggg cgttgtcctc acggcatcgt tgtggtcaat
    20941 ctgggcggca acggccacgg ggccgtcaaa aacgcgtcga ccagcgggca caccggcccg
    21001 ttcgacaccg aactggcccc gcagccaccg gctcggccag tgggcggccc gccacggcct
    21061 ggtcggcgac gacgcggcac tccttcatat gcggctcacc cagatcagga caacggtcga
    21121 agcccgcacg gccaagaagg tcggcggtca cctgccctcc gcgcggctga ccaacaccgc
    21181 caacgtgggc ggctccaatg atcgcccacg atctacgccg gatacgccag ccccgcgtcg
    21241 gactcggctt gggatgtcgc cacggccgtg aacgtcagga ctctggagcg ctcacgagca
    21301 agcgcacgcg cgattcgctc gattccatcg tcttcgcact tgaatcaagc gcgttgatcc
    21361 ggcattgtgc ttgaaacaag cgcaacgcct gccgttcacg caggagagag gtgctgcatg
    21421 gacgacatcg accgggccat cctgcgggag ctgcaggtcg acggccggat cccttacgcc
    21481 gatctagggc cgaaggtggg gttgtcaccc tcggccgcga ggctccggct gcagcggctg
    21541 atcgacacca aggcggtcca ggtcgtcgga gtgaccgacc cgatgaccat gggtcagcag
    21601 acgatggcac tcctgggctt gcgcatcgac ggcgatcccc gggcggtcgc cgatgaactg
    21661 tcccggcacg acgaagtcgt gtacacggtc ctgacggccg gcggcttcga cctgttcgcg
    21721 gaggtcgtgt gcagtcagcc tcgggatctt ctggacttca tcaacgacgt cgtgcggccc
    21781 gtcgagggtg tcgcatccgt ggagaacttc ccctacttcg cgattcacac tcaccgcttc
    21841 ttgtggcacg tcgactgagg catccgagcg tcccagccct gcttgcccgc accagccgag
    21901 gaaccctgca tgccgaccga cgactgccgc acgatcgact tcttcaccga ggacgccctt
    21961 cccgcacccc gcgtggcgcc ggccgaggct gagcgcatcg ctgccgaaca cctcgacatc
    22021 acagctcgcg cgcaggcgct gggcagccag caggacgcca acttcctgct gcacgccgac
    22081 gatgggacgc ccgcggcgat tctgaagatc gccaaccccg ccttcggcac tgtggagatc
    22141 ga
//
