LOCUS       NZ_BMMM01000005        10216 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces albiflavescens strain CGMCC 4.7111 sequence05, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMM01000005
VERSION     NZ_BMMM01000005.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces albiflavescens
  ORGANISM  Streptomyces albiflavescens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 501710)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 100X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645835.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:24:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,828
            CDSs (total)                      :: 9,745
            Genes (coding)                    :: 9,386
            CDSs (with protein)               :: 9,386
            Genes (RNA)                       :: 83
            rRNAs                             :: 1, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 102 of 359
            Pseudo Genes (incomplete)         :: 321 of 359
            Pseudo Genes (internal stop)      :: 17 of 359
            Pseudo Genes (multiple problems)  :: 80 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:54:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 102766
            Orig. end                         :: 112982
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMM01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(560..574)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.46"
                     /tool="antismash"
     misc_feature    1558..1573
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.25"
                     /tool="antismash"
     gene            complement(1882..4104)
                     /locus_tag="IEY95_RS15490"
                     /old_locus_tag="GCM10011579_031410"
     CDS             complement(1882..4104)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="IEY95_RS15490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_031410"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_189186619.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.7e-40, bitscore:
                     130.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAQDTRGRRRAAPPKRTVPKSRRKTVRTPTVLQMEAVECGAAS
                     LAMVLGHYGRHIPLEELRIACGVSRDGSRASNLLKAARSYGLTAKGMQMDTAALAEVQA
                     PAILFWEFNHYVVYDGMGRRFGRRGVHINDPGKGRRFVPMEDFDTSFTGVVLVMEPGPD
                     FRKGGRRPGVLGAMPARLRGTSGTMPAAVLASLLLVVVGAALPALSRTYIDQYLIGGQS
                     SLLGVLFASMGASVLLTVVLTWLQQANLLRGRIISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAIVVVLYAVLLYTYDPQLTAVGIGVALLNVV
                     AMRVVIRLRATRTAKLRADTARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATLNSALILWIGGMRAIEGHISVGLLVAFQALVTRFTAPI
                     TRLNGVAGRIQDFAADVARLKDVENFQADPLYARSGTGESTRRLHGHVELENITFGYSP
                     LDKPLLTGFSLTVGPGQQVALVGGSGSGKSTVSRLISGLYAPWEGTIRMDGQRLEDIPR
                     GALAASVSFVDQDVFLFEGTVRDNIALWDPSIPEDAVVAALEDAALYDVVMRRPGGIHS
                     RVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETEQTVMDNLRKRGCACV
                     VIAHRLSTVRDSDEIVVLQHGTIVERGRHDALVAAGGPYAELVKER"
     gene            complement(4101..4910)
                     /locus_tag="IEY95_RS15495"
                     /old_locus_tag="GCM10011579_031420"
     CDS             complement(4101..4910)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="IEY95_RS15495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_031420"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_189186620.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRFARPQGWLVLSVTVVVMAAASVW
                     AVTGTVASTVGAPAILTHGEGSYVLQSPVAGQVTAVLAKEGERLAANAPVLKVRTAQGE
                     TAVVRTVAAGRITALAATIGAIISTGANVAAVEKVAHADDPLYATVYVPAENASTIPAN
                     AAVDLTVQSVPTQQYGVLRGHVKAVDRTVQTQQQIASFLGDSQLGEQFTKKGRPVAVLV
                     RLDRSSGTKSGLKWSSADGPPFALTSMTLATGSIRMADQRPIDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="IEY95_RS15500"
                     /old_locus_tag="GCM10011579_031430"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="IEY95_RS15500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_031430"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_189186621.1"
                     /sec_met_domain="strepbact (E-value: 1.5e-37, bitscore:
                     123.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPRVETAEISDADLDNVSGGLSLNAVGTVTGLVDSVAPVSGL
                     VGTGVGTVEGVTGLNTAPVTGLVAGL"
     misc_feature    complement(5237..5250)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.42"
                     /tool="antismash"
     misc_feature    5239..5252
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.46"
                     /tool="antismash"
     misc_feature    5367..5380
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     gene            complement(5698..6111)
                     /locus_tag="IEY95_RS15505"
                     /old_locus_tag="GCM10011579_031450"
     CDS             complement(5698..6111)
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676669.1"
                     /locus_tag="IEY95_RS15505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_031450"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_189186622.1"
                     /transl_table=11
                     /translation="MTLNLAEADKILADHFAPWVLDLGLSVAELGDQRAILRLPWSARL
                     AREGGSLSGQALMAAADTATVIAVSAARGAFVPMTTVQQSTSFQRAVTDADVLVEAVLT
                     KLGRRMAFADITMTAEGADEIAARASTVYALLG"
     misc_feature    complement(6189..6205)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.34"
                     /tool="antismash"
     gene            6307..7668
                     /locus_tag="IEY95_RS15510"
                     /old_locus_tag="GCM10011579_031460"
     CDS             6307..7668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430713.1"
                     /locus_tag="IEY95_RS15510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_031460"
                     /product="S1 family peptidase"
                     /protein_id="WP_189186623.1"
                     /transl_table=11
                     /translation="MSHKRIPKRKAALAAGSVAALGAAALLLPHANASQTNSDDATPKT
                     FKAAGVADVASQLASQLGDAFAGSYYDASKQQLIVNVVGDNSNVVNQIEKAGAVAHQVQ
                     NSTSALQAAAKTLKTDATIPGTAWAVDPKTNKIQVTADSTVTGAKWNKLTSTVDSLGSG
                     VADVKKSGGTFKTFVSGGDAIFAQANGGGVRCSLGFNVTASDGSPAFLTAGHCGVAAKQ
                     WSDSQDGQPIATVDQATFPGAGDFSLVKYDDPNTQAPSEVNVGNGQTVQINQAADATVG
                     QQVLRMGSTTGLHDGSVTGLDATVNFQSETDPNGVDTVTGLIQTDVCAEAGDSGGSLFT
                     QDGSAIGLTSGGSGDCTTGGETFFQPVTTALAAVGATLGAGDAGAGAGAGDGGAADPSA
                     SASDPAGAGDQAGGADDQAGGAADPSGAADPSGAAGDQSGTGMDDGSGLVTSTP"
     gene            complement(7856..10015)
                     /locus_tag="IEY95_RS15515"
                     /old_locus_tag="GCM10011579_031470"
     CDS             complement(7856..10015)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057833.1"
                     /locus_tag="IEY95_RS15515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_031470"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_189186928.1"
                     /transl_table=11
                     /translation="MVGVSDRQGSGQAPAGGRPAPVGKPLLSLTLTAMMDDVHAHAGGV
                     YLLAPHEPVLEMAAMAGLPRAFAAPWERVGLSAPIPVAEAVRERRLIWVSGEEQMASRY
                     PRIALVLPYPFALAALPVATGNKTYGAVFVTWPGSHPPELSDRERDHLTAACDRLALRL
                     ERAAEEQRPVHPEPELPAPATTATVAGTLGTVEVARMVARLPYGLCAMDLHGRISYANA
                     ATAELLGVRVSDLLGTQLWASVPWLNDPVYEDRYRAALLSQQVTSFVALRPPGDWLSFR
                     LYPSTNGLSVRISRARAVTEMTRTGPRRGDDTPRLATISHVLSLASALTEAAGVQDVVQ
                     LVADEVAPAVGSQALVVLGSRAGRLHVLGHRGYPDAHVVECFDGMPLSAQTPGTHALNS
                     GVPAFFDSRQQLERLYPSLNATPDGMAAWAYLPLIASGRPVGICVLAYAQPHAFPADER
                     AVLTSLGGLAAQALERALLYDAKLQLAHGLQAALLPPSLPSLPSIEAAARYLPATQGMD
                     IGGDFYDLVPSRDRAAAVIGDVQGHNVTAAGLMGQIRTAVRAYTTVGQPPEEVMGSTNR
                     LLFDLGTDLFASCLYLRLDPAREVAVMARAGHPPPLLRRPDGKVRVLDLAGGPLLGIDA
                     SATYPTTEVPLAPGSVLTLYTDGLIESPGVDIEDALADLGRRLAETGDQPLDTLADSLV
                     RHGGTATQERPDDVALLLLRARPLD"
ORIGIN
        1 aacggcagat acaccgcgcc catcaccgtg gtgaggttct tgatgcggcc gaccttctgc
       61 tggagttcac ggctgcgcgc gaactcgctc gcccaggcgg cgtacgcgta gttctcggcc
      121 gccgcgaccc gcagcttggg cagtcctcgc agggtctgga acgcctggtt gttcagcttg
      181 ttgctgagta cgacgaggcg gcgctgccag cgcacctgcc acaggcccag gcccaggaac
      241 ccggccgcga tgacgacgag catgccgatc gcggccagag ccatcggcac gctgtaccag
      301 aacagcagcc ccaggttcat cgcgccgagc gtgcctgcct gcgcgaccgt cgggccgacg
      361 cccgcgagga gccgacggat cgcgctgatg cccatggcgg cactggcgag ttcaccggtc
      421 gagcgtgagg tgaagaactt ggtcggcagc ctgagcagcc ggtcccacac ggccggttgg
      481 agcgtggcct cgatccggcc ctccatgcgc agcatcgtga ggttctgcag cagcatgaac
      541 gccgccgaca cgatgctggt gatcatgatg gccagacaga cctgcacgat gagaccgtgc
      601 tgggccttcg gcacgtactc gccgagcacc ttgccggtgg cgatcggcac cagcgcgccg
      661 atcgccacgg tcaccagacc gctgatggcg aggttgcgca gatcgccacc cgtgccctga
      721 agacagaagc gaagcagccg cagcgggctc aacttccgtt cgggcagcgg gcggtagaac
      781 atcacggccc gcggctcgaa ctccgccgcg ttcgccttct cgaccggcgt ctcgcgcccg
      841 gacgacggct gcacggccac atatccgccg cgccgccaca gcagcgcgac cggcgcaccg
      901 gacacggccc ggtggcctat cagcggaccg atgttgtccc gccaccagcg cccgtcgagg
      961 cgtacggcac gggtgcggac gcgtgaggcg agcgcgatcc gctcgaccgg gtcgagccgg
     1021 tcgctctccg ttccgctctg cgcggactcc gccaacgaga tcccggtctc gcgggcgacc
     1081 agcttgcagg ccgcgtaggt ggcatcggcg tcggccgcgg tcggccgctt caccgacgac
     1141 ttgccgatgg acgcgagcag cgtccggtcg gcctgggcac ggacggcctc gcccgccttg
     1201 atgcccgccg ccgtacggtc ctcgtggctg gcctccaact gctcgatcca gcggtcgagc
     1261 gtggtcagca ggcggtactg ctggtcgacc atgctctgcc agacacccgg gtccatcagc
     1321 aggtcggcgg ccgcttcggc gccgtacagc gagccgtact gcacactgcc cggcggcacc
     1381 tgcatccaga agacgtcgtc gtccgtgagc gcggcggcgt tctccgtggc catcggcgcc
     1441 tggaagagga tggagaggct gcggccgacg ccgagggcga gggcgtactc caacgggctc
     1501 gaagtcggcg gcacgtactg ggggttgccg tactcgtcgt acgaccaggt ctcggtgttg
     1561 accggctggt acagctcgcg cagcacgatc cggtgcacca cgcagtcgcg cagcgggcgt
     1621 cccacgaggg tgtgctgggg gcccgcgacc gggccgagga gaagggagcc cgcttcgagg
     1681 cggccgaggt ggtgccaatg gccctgctgg gcggcgtcga ccgcgaacag gtccatggag
     1741 cccgccgcga cgagccagag gacttggggg ccttccagat cgaggcggtt gaggccggag
     1801 cagtcgatcg gcgtgcccat gctgccgagc gcaccgagga cgaggtctcc ctcgtgaacg
     1861 ccctcgtgaa ccgtggtcat ctcatcgctc cttgaccagc tcggcgtacg ggccgccggc
     1921 cgccaccagg gcgtcgtgcc gcccgcgttc cacgatcgtg ccgtgctgaa gtacgacgat
     1981 ctcgtcgctg tcgcgcactg tgctgagccg gtgggcgatc acgacacagg cgcagccgcg
     2041 cttgcgcagg ttgtccatga cggtctgctc ggtctccgcg tccagcgcgc tggtcacctc
     2101 gtcgagcacc aggatgctgg gcctgcggac caacgcccgt gcgatctcca ggcgttgacg
     2161 ctggccgccg gagaaattgc gcccgtcctg ctcgacccgg ctgtggatgc cgccgggacg
     2221 gcgcatgacc acgtcgtaca gcgccgcgtc ctccagcgcc gccaccacgg cgtcctccgg
     2281 gatcgacggg tcccacaggg cgatgttgtc gcggaccgtt ccctcgaaga ggaagacgtc
     2341 ctggtcgacg aaggacacgg aggccgcgag ggcgccgcgc gggatgtcct ccaggcgctg
     2401 cccgtccatg cggatcgtgc cctcccaggg ggcgtacaag cccgaaatca gcctggacac
     2461 cgtcgacttg ccgcttcccg aaccgccgac cagtgcgacc tgctggcccg ggccgaccgt
     2521 cagcgagaag ccggtgagca gtggcttgtc gagtgggctg taaccgaacg tgatgttctc
     2581 cagctcgaca tggccgtgca gacggcgggt ggactcgccg gtaccggagc gggcgtagag
     2641 cgggtccgcc tggaagttct cgacgtcctt gagacgggcc acgtcggccg cgaagtcctg
     2701 gatgcggccc gcgacgccgt tcagccgcgt gatcggcgcg gtgaagcggg tgacgagggc
     2761 ctggaaggcg accagcagac ccaccgagat gtgtccctcg atcgctcgca taccgccgat
     2821 ccacaggatc agcgcggagt tgagcgtcgc gagcgtcggc gcgaccacgc ccagccaggc
     2881 gctcggcacg ccgaggcgct gctgctcctc cagcgtggtg gcgtgctgtc cggcccactt
     2941 gcggaagtag ccgtcctcgc cgccggtggc cttcatggtc tcgatcagct ggagcccggt
     3001 gtaggccgtg ttggtgagcc gcgcggtgtc ggcgcgaagc ttcgcggtgc gggtcgcgcg
     3061 cagccggatc accacccgca tggccaccac gttgagcagc gccacgccga tgcccacggc
     3121 ggtgagctgc gggtcgtagg tgtagagcag tacggcgtag agcacgacca cgatcgcgtc
     3181 cacaccggcc gccgcgagat cgcgggccag ggtctcggcc accgcgtcgt tcgactggag
     3241 ccgctgcacc aggtcggccg ggctgcgctg ggagaagaag gtgaccggca gccgcagcag
     3301 atggcgcagg aagcgggcgc tggagagcgt cgaggagatg atgcggccgc gcagcagatt
     3361 ggcctgctgc aaccaggtca acaccaccgt gagcagcacg gaggcgccca tcgacgcgaa
     3421 cagcacgccg agcagagagc tctggccacc gatcagatac tggtcgatgt acgtccggct
     3481 gagcgcgggc agcgccgcgc cgaccaccac cagcagcagg ctcgccagca cggccgcggg
     3541 catggtgccc gatgtgccgc gcagccgggc cggcatggcg cccaggactc ccggcctgcg
     3601 gccgcccttg cggaagtcgg gccccggctc catgaccagg acgacacctg tgaagctggt
     3661 gtcgaagtcc tccatcggca cgaatcggcg gcccttgccg gggtcgttga tgtgcacgcc
     3721 gcgccgtccg aagcggcgac ccatgccgtc gtacacgaca tagtggttga actcccagaa
     3781 caggatcgcg ggcgcctgga cctcggcgag cgcggccgtg tccatctgca tgcccttggc
     3841 cgtcaggccg taactacgtg ccgccttgag caggttgctg gcgcgcgagc cgtcccgcga
     3901 gacaccgcac gcgatgcgca gctcttcgag cgggatgtgc cggccgtagt gtccgaggac
     3961 catggcgagg gaggccgcac cgcactcgac ggcctccatc tggagcacgg tgggggtgcg
     4021 gacggtcttg cgcctgctct tgggaaccgt gcgcttcggt ggggcggcgc ggcgtctgcc
     4081 ccgggtgtct tgtgcggtgg tcacggcagg agccaatcga tggggcgctg atcggccatg
     4141 cggatcgaac ccgtggccag ggtcatggaa gtgagcgcga acggcggtcc gtccgccgag
     4201 gaccacttga ggccgctctt cgtgccggag gaccggtcga ggcggaccag gacggccacc
     4261 ggcctgccct tcttggtgaa ctgctcgccc agctggctgt caccgaggaa ggaggcgatc
     4321 tgttgctggg tctgaacggt ccggtcgacc gccttcacat ggccgcgcag caccccgtac
     4381 tgctgggtgg gcaccgactg gacggtgagg tcgacggcgg cgttcgcggg aatcgtggag
     4441 gcgttctccg cggggacgta cacggtcgcg tagagcggat cgtcggcgtg ggcgaccttc
     4501 tccacggcgg cgacgttcgc gccggtcgag atgatcgcgc cgatggtggc ggcgagcgcg
     4561 gtgatgcggc cggctgcgac cgtccggacg acggccgttt ccccttgcgc cgtacggacc
     4621 ttcagcacgg gggcgttcgc ggcgagccgt tcgccctcct tggcgaggac tgcggtgacc
     4681 tgcccggcga cggggctctg cagaacataa ctgccctccc cgtgcgtgag gatggcgggt
     4741 gcgccgaccg tggaggcgac ggtgcccgtc acggcccaca cggacgcggc cgccatgacg
     4801 acaaccgtca cggacagtac gagccagccc tgcgggcggg cgaagcgcac cggaaggtcg
     4861 agctcttcgg gcgattgcag cttggcgagg gcctgttggc ggaactgcac gggacttccc
     4921 tcacctgttc gagagattta tggcatccga gagtcccgga accgggaagc ggttccggga
     4981 ctcaacggca tgaaatgcga tcagagaccg gcaaccaggc cggtgaccgg ggcggtgttc
     5041 aggccggtca caccctcgac ggtgccgacg cccgtgccca cgaggccgga gaccggggca
     5101 acgctgtcga ccaggccggt gacggtgcca acggcgttca gcgacaggcc gccggacacg
     5161 ttgtcgaggt cggcgtccga gatctcggcg gtctcaacgc ggggggtgga gttcatgatg
     5221 gaacttccct tcgtctggat atttaaaaaa ggggagagcg gccccctctg ggggacagat
     5281 gacggccgcc accgcgagcg cgcggcgccc gtttccggga gcctcggtgc gacccccgcg
     5341 gtgcaacgga tcaaagcacg cccgcgtggc acgtatccaa tcaaccaggg ctctcacctg
     5401 ggcacttgag cactttggcc gtccaaccgt gcaggcgtgc acacgtcttt gcggcgactt
     5461 cttcacatgc tgcgccgcat cggttcgtgc gctcccttgc cgcctcggga ccgaatggga
     5521 cagtcccgtc gcaatggcgc ggaggggggc gcgcgactgt gcagatctgt cgcgcgccgt
     5581 gacttcgttg cgcattcgat gtgcagattc gccgaagccg ggattccgtt cttggccgcg
     5641 aacggaccgt taccgatcag tggcggaatg tgtcgtgcgt gccgggtgca cgtccgctca
     5701 gcccaggagc gcgtacaccg tgctcgcccg cgccgcgatc tcgtccgccc cctcggcggt
     5761 catcgtgatg tccgcgaagg ccatccggcg gcccaacttg gtgaggaccg cctcgaccag
     5821 cacgtccgcg tccgtcaccg ctcgctggaa gctcgtggac tgctggacgg tggtcatcgg
     5881 gacgaaggcg ccgcgcgccg cggacaccgc gatcacggtc gccgtgtcgg ccgcggccat
     5941 cagtgcctgg ccggacagcg agccgccctc ccgggcgagc cgcgcggacc acggcagccg
     6001 caggatcgcg cgctggtcgc ccaactccgc cacggacagg ccgaggtcga gcacccaggg
     6061 ggcgaagtgg tcggcgagga tcttgtcggc ttcggcaagg ttcagcgtca tacgaggcat
     6121 tgttccccag tcactcggcc caaaggcggg attgcctcgc aatccatgcc tttcgccgag
     6181 gtaactcctg cctttcttaa aggcagttga acaacccacg tggctcacgc gtatcaacaa
     6241 ccatccaggc gccccccagt cagctgccgg acggcggcat cgaccccgtc cccaggaggt
     6301 caagagttga gtcacaaacg gatacccaag cgcaaggccg ccctcgcggc aggaagcgtg
     6361 gcggcgctcg gagcggcggc acttctgctg ccccatgcca acgcgtccca gacgaactcg
     6421 gatgacgcga ccccgaagac gttcaaggcg gccggtgtcg cggacgtcgc ctcgcagctc
     6481 gcctcccagt tgggtgacgc cttcgccggg tcgtactacg acgcctcgaa gcagcagctc
     6541 atcgtcaatg tcgtcggcga caacagcaat gtcgtcaacc agatcgagaa ggccggcgcc
     6601 gtcgcccacc aggtgcagaa cagcacctcc gcactccagg ccgccgccaa gacgctgaag
     6661 acggacgcga cgatcccggg cacggcgtgg gccgtcgacc cgaagaccaa caagatccag
     6721 gtcaccgccg acagcacggt cacgggtgcc aagtggaaca agctgacgtc gaccgtcgac
     6781 tcgctcggtt ccggcgtggc cgacgtcaag aagtccggcg gcacgttcaa gacgttcgtg
     6841 tcgggcggtg acgccatctt cgcccaggcg aacggcggcg gtgtccgctg ttccctcggc
     6901 ttcaacgtca ccgcgagcga cggcagcccc gccttcctga ccgccgggca ctgcggtgtc
     6961 gcggccaagc agtggtcgga ctcgcaggac ggccaaccga tcgcgaccgt cgaccaggca
     7021 accttccccg gtgccggcga cttctcactc gtgaagtacg acgaccccaa cacccaggcg
     7081 ccgagcgagg tcaacgtcgg caacgggcag accgtccaga tcaaccaggc ggcggacgcc
     7141 acggtcggtc agcaggtcct ccggatgggc agcaccaccg gtctgcacga cggctcggtc
     7201 accggtctgg acgccacggt caacttccag agcgaaaccg accccaacgg tgtcgacacc
     7261 gtcaccggtc tcatccagac cgatgtctgc gccgaggcgg gcgacagcgg cggctccctg
     7321 ttcacccagg acggcagtgc gatcggcctc acctcgggcg gcagcggcga ctgcaccacc
     7381 ggcggcgaga ccttcttcca gcccgtcacg accgcgctgg cagcggtcgg tgcgacgctc
     7441 ggcgcgggag acgccggggc cggggccggg gccggtgacg gcggcgcggc cgacccgagc
     7501 gccagtgcca gtgacccggc gggcgcgggc gaccaggccg gtggcgccga cgatcaggcc
     7561 ggtggcgccg cggacccgag cggagccgcg gacccgagcg gagccgccgg agaccagtcc
     7621 ggcaccggca tggacgacgg ctcgggcctg gtgaccagca ccccctgacg gccggtcacc
     7681 aagaaccact gagccggccg cggaacagcg gtcccggtcg gcagtggaag ggtccggccc
     7741 tccggcggga gggccggacc gcccctgttc gggccgcccg cgtacggacc ccccccgcgt
     7801 acggaccccc cgcgtatcga ccgcaccacc ggacgactgc gcctgtggcg cccgttcagt
     7861 cgagtggtcg tgcccgcagc aggagcagcg cgacatcgtc gggccgctcc tgcgtcgccg
     7921 tcccgccgtg ccgcacgaga ctgtcggcca gcgtgtccag gggctggtcg ccggtctcgg
     7981 cgagccgtcg gccgaggtcg gcgagggcgt cctcgatgtc gacaccgggg gactcgatca
     8041 gaccgtcggt atagagagtg agcacggagc cgggggcgag cggcacctcg gtcgtgggat
     8101 acgtggccga cgcgtcgatc ccgagcagcg ggccaccggc caggtcgagc acccggacct
     8161 tgccgtccgg ccgccgcagc aacggcggcg gatggcccgc acgcgccatg acggccacct
     8221 cgcgcgcggg gtcgagacgc agatacagac agctggcgaa gaggtcggtg cccaggtcga
     8281 acagcagccg gttggtgctc cccatcacct cctccggcgg ctgaccgacg gtcgtgtacg
     8341 cccgtacggc ggtgcggatc tgccccatca ggcccgccgc cgtcacgttg tggccctgaa
     8401 catcgccgat caccgccgcg gcccggtcgc gcgagggcac caggtcgtag aagtccccgc
     8461 cgatgtccat gccctgagtg gccgggagat agcgtgcggc cgcctcgatc gagggcagcg
     8521 acggcagcga gggcggcagc agagcggcct gcagaccgtg cgccagctgg agcttggcgt
     8581 cgtagaggag ggcacgctcc agcgcctgcg cggccagccc gcccagactc gtcaggacag
     8641 cacgttcatc ggcggggaag gcgtgcggct gggcgtacgc caggacgcag atgcccaccg
     8701 gccgcccgga cgcgatgagc ggcagatagg cccaggcggc catgccgtcc ggcgtcgcgt
     8761 tcagggacgg gtagaggcgc tccagctgct gacgcgagtc gaagaaggcg ggaaccccgg
     8821 agttcagcgc gtgggtaccc ggggtctgtg cgctgagcgg catcccgtcg aagcactcca
     8881 cgacgtgcgc gtccggatag ccccgatgcc cgagcacgtg caggcgcccg gcccgcgagc
     8941 cgaggacgac cagggcctgg ctgccgacgg cgggcgcgac ctcgtccgcg accaactgca
     9001 ccacgtcctg cacgcccgcc gcctccgtga gtgcgctcgc cagactcagc acatgggaga
     9061 tggtggccag gcgcggcgtg tcgtcgccgc gccgcggccc ggtacgggtc atctcggtca
     9121 ccgcccgggc ccgtgagatg cgcacgctca gcccgttcgt actgggatac aggcggaacg
     9181 acaaccagtc gccgggtggc cgcagcgcca cgaacgacgt cacctgctgg ctgagcagag
     9241 cggcacgata ccggtcctcg tagacggggt cgttgagcca gggcacggac gcccacagct
     9301 gggtgcccag caggtcgctg acccggacgc ccagcagctc cgccgtcgcc gcgttggcgt
     9361 agctgatccg cccgtgcaga tccatcgcgc acagcccgta cggcagccgc gccaccatcc
     9421 gtgcgacctc cacggtgccg agtgtgccgg ccacggtcgc cgtagtggcg ggtgccggca
     9481 gctccggctc ggggtgcacg ggacgctgct cctcggcggc ccgctcgagg cggagcgcga
     9541 gtcggtcgca ggccgcggtg agatggtcgc gttcccggtc ggacagttcc ggcggatgcg
     9601 agccgggcca ggtcacgaag acggcgccgt acgtcttgtt cccggtcgcc acggggagcg
     9661 cggccaacgc gaatggatag gggagcacca aggcgatccg tggatagcgg ctggccatct
     9721 gctcctcgcc gctgacccag atcagtcgcc gctcccgcac cgcctcggcc accgggatcg
     9781 gcgcgctcag tcccacccgc tcccacggtg cggcgaaggc cctgggcagt cccgccatgg
     9841 ccgccatttc caggaccggc tcgtggggcg ccagtagata gaccccgccg gcgtgggcgt
     9901 ggacgtcgtc catcatcgcg gtcagcgtca gcgagagcag cggctttccg accggcgccg
     9961 gtcgaccccc cgccggtgcc tgcccggacc cctgccggtc ggacacgccg accacctcct
    10021 cgcagggccg cgcacatgtc ccaggggtca aggctccctc ttggcggccc ctcccgcacg
    10081 gcgagcggac cgccggacgc gccgcgcaca acccacccgg ggatcccgcc cggcggacgg
    10141 aagtcccgct gccaccgcga cggcgcgggc ccgacgggtt cggaacggtc acaggggctg
    10201 cgcgagcgtc ccggaa
//
