LOCUS       NZ_BMMM01000002        10528 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces albiflavescens strain CGMCC 4.7111 sequence02, whole
            genome shotgun sequence.
ACCESSION   NZ_BMMM01000002
VERSION     NZ_BMMM01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces albiflavescens
  ORGANISM  Streptomyces albiflavescens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 998938)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 100X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014645835.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 03:24:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,828
            CDSs (total)                      :: 9,745
            Genes (coding)                    :: 9,386
            CDSs (with protein)               :: 9,386
            Genes (RNA)                       :: 83
            rRNAs                             :: 1, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 359
            CDSs (without protein)            :: 359
            Pseudo Genes (ambiguous residues) :: 0 of 359
            Pseudo Genes (frameshifted)       :: 102 of 359
            Pseudo Genes (incomplete)         :: 321 of 359
            Pseudo Genes (internal stop)      :: 17 of 359
            Pseudo Genes (multiple problems)  :: 80 of 359
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:54:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 425256
            Orig. end                         :: 435784
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMMM01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10528
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="3"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10528
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10528
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5528](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5528
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(165..464)
                     /locus_tag="IEY95_RS06845"
                     /old_locus_tag="GCM10011579_013870"
     CDS             complement(165..464)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IEY95_RS06845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10011579_013870"
                     /product="hypothetical protein"
                     /protein_id="WP_189184967.1"
                     /transl_table=11
                     /translation="MRHSPGLPMRRAMVGCSVLAARCAPGGPAMAAPPGEAESLAFTQQ
                     HHALRHGGIVGAAHSPISCRTTPLPARLAAPLRLASQRDTARGGALFAAADAKQ"
     misc_feature    complement(747..761)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.66"
                     /tool="antismash"
     gene            785..1024
                     /locus_tag="IEY95_RS06850"
                     /old_locus_tag="GCM10011579_013880"
     CDS             785..1024
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136063.1"
                     /locus_tag="IEY95_RS06850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013880"
                     /product="chaplin"
                     /protein_id="WP_189184968.1"
                     /transl_table=11
                     /translation="MSRIAKGLALTSVAAAAVAGTAGIAAANSDAHGAAAYSPGVASGN
                     VVEVPVHVPVNLCGNTVDVIALLNPAFGETCGNG"
     misc_feature    complement(1176..1189)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.85"
                     /tool="antismash"
     gene            1275..2021
                     /locus_tag="IEY95_RS06855"
                     /old_locus_tag="GCM10011579_013890"
     CDS             1275..2021
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660307.1"
                     /locus_tag="IEY95_RS06855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013890"
                     /product="hypothetical protein"
                     /protein_id="WP_189184969.1"
                     /transl_table=11
                     /translation="MRALPARRIATSALCATLLIGIATPAALAADSDSTRGRSHAAAPV
                     PGADALLAQVQSLADIGGVLTPVTELVAAALKADNGQLSADDAAKLGQAVKDAIAKVTA
                     AAPVTPPVALPTTPPTTLPTTAPTVTKEPTTPTTSTLPATKNADHRDGKARGADGPRAE
                     APADLKGDALTALQKAVDTLLKAVTSGDPTGVVPAATAVVTGLVNFVVATVLGGGLPAA
                     NLPGLPSLPSTLPTSSLPTSGLVPTS"
     gene            2300..2602
                     /locus_tag="IEY95_RS06860"
                     /old_locus_tag="GCM10011579_013900"
     CDS             2300..2602
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136064.1"
                     /locus_tag="IEY95_RS06860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013900"
                     /product="hypothetical protein"
                     /protein_id="WP_189184970.1"
                     /transl_table=11
                     /translation="MKSLKAAAVVAGSMVIAGAATPAFAAEASDLTPSSLNGAVETITS
                     QRTLNVEDVMPLQHQSKALDTENKGSLLNAVSGATKALNTTGGPARLLGGLPLQS"
     misc_feature    complement(2658..2674)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.57"
                     /tool="antismash"
     gene            2689..2928
                     /locus_tag="IEY95_RS06865"
                     /old_locus_tag="GCM10011579_013910"
     CDS             2689..2928
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743016.1"
                     /locus_tag="IEY95_RS06865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013910"
                     /product="chaplin"
                     /protein_id="WP_189184971.1"
                     /transl_table=11
                     /translation="MNTVKKIALIFAAAGIAAGAASGAAFADTGADAAALTSPGVVSGN
                     VIQIPVHVPVNLCGDSVDVIGLLNPAGGTSCTNH"
     gene            3093..3593
                     /locus_tag="IEY95_RS06870"
                     /old_locus_tag="GCM10011579_013920"
     CDS             3093..3593
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116484.1"
                     /locus_tag="IEY95_RS06870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013920"
                     /product="DUF5949 family protein"
                     /protein_id="WP_189184972.1"
                     /transl_table=11
                     /translation="MTSTSSETRPFRVADLGTLAVMAFSGDAPDGDMPYLLAYSLGDAE
                     GGPEGTSAAIERLLRKNGLPVGDRLIDGSRRPSLPLALLVEAGQAVVTMPAYLKAQCVA
                     PPEWLAAVGERGYAYFLFATRAWPEATPGKPVAPESLAAFAGDEETLLSAAHVLLPVRN
                     LRS"
     gene            3593..4219
                     /locus_tag="IEY95_RS06875"
                     /old_locus_tag="GCM10011579_013930"
     CDS             3593..4219
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447554.1"
                     /locus_tag="IEY95_RS06875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013930"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_229702635.1"
                     /transl_table=11
                     /translation="MTSTAGRTAGGDGAVVPTVGGSRAFALLLVITGAAGLLAAWVITI
                     DKFKLLENPNFVPGCSLNPVVSCGNIMKSEQASAFGFPNPMLGLVAYGIVICVGMSLLA
                     RATFPRWYWLTFNAGTLFGVGFCTWLQFQSLYRINALCLWCSLAWVATIIMFWYVTSLN
                     VRHEFLPAPDWLRGFLGEFTWVLPVVHIGVIGMLILTRWWDFWTS"
     gene            4355..4873
                     /locus_tag="IEY95_RS06880"
                     /old_locus_tag="GCM10011579_013940"
     CDS             4355..4873
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976098.1"
                     /locus_tag="IEY95_RS06880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013940"
                     /product="hypothetical protein"
                     /protein_id="WP_189184973.1"
                     /transl_table=11
                     /translation="MKPTTRGTLAAVMTGVAATMGAAVATPAVAAGTVPVPVPLDGVEN
                     ALNVKAPKISGELPVPMPGGPRGPRYVEGRLIPEHVLPQLPVNGGLPGANVHTPLPHVL
                     GDGFDHFGVGAPAADLRTLTPGLSLDTPLTAPKADHFGLPDAKLPQVAVLTPLLKTVPA
                     ANLDMGAGA"
     gene            5001..5528
                     /locus_tag="IEY95_RS06885"
                     /old_locus_tag="GCM10011579_013950"
     CDS             5001..5528
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065674.1"
                     /locus_tag="IEY95_RS06885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013950"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_189184974.1"
                     /sec_met_domain="melC (E-value: 1.8e-42, bitscore: 140.6,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVSRASSSVSSKVPRSVSSGVSVTRRGAMRGLLVSAFAVALTPV
                     VAASRPPRETRQEDPSFDEVYRGRHILGTRTGTDARASFDGGYDRGYGGGHSGGPGGSE
                     WHVTVDGKPLQLMRRADGSYLSMVDHYESYPTALAAVRAAVDELGPSEHLRGMDAAGSD
                     TEGSSYRHGVHA"
     gene            5512..6378
                     /locus_tag="IEY95_RS06890"
                     /old_locus_tag="GCM10011579_013960"
     CDS             5512..6378
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="IEY95_RS06890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013960"
                     /product="tyrosinase family protein"
                     /protein_id="WP_189184975.1"
                     /transl_table=11
                     /translation="MAYTRKDVSKLTGAERRRFVAAMLEVKRRGEYDEFVRMHIEYYVA
                     DGDGGLRTAHMAPSFLPWHRRFLLDLERALRRVDSGVSVPYWDWTRHRTTTSVPWTNDL
                     LGGNGRRSDRQVMTGPFAYAHGKWTIREGVTDGEFLRREFGRPLDRIELPTKKELESAL
                     KDPVYDTAPWNSTSTGGFRNKLEGWGHGSGSAAWRNHNRVHRWVGGHMLGGASVNDPVF
                     WLHHAFVDLLWDRWQQRHRGARYLPARPPAPGDSQHRRVVARHEKMPPWGETPGAQEHH
                     SRIYRYA"
     gene            complement(6455..6736)
                     /locus_tag="IEY95_RS06895"
                     /old_locus_tag="GCM10011579_013970"
     CDS             complement(6455..6736)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449724.1"
                     /locus_tag="IEY95_RS06895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013970"
                     /product="chaplin"
                     /protein_id="WP_189184976.1"
                     /transl_table=11
                     /translation="MSRIAKAAVVAAGTGAVVLSGAGLAMANTGAQGEAVGSPGVVSGN
                     AVQVPINVPVNVCGNTADVIGLLNPAFGDHCGNYDDQGQEREGYGYGN"
     misc_feature    6857..6877
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            6931..7554
                     /locus_tag="IEY95_RS06900"
                     /old_locus_tag="GCM10011579_013980"
     CDS             6931..7554
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449721.1"
                     /locus_tag="IEY95_RS06900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013980"
                     /product="DUF2087 domain-containing protein"
                     /protein_id="WP_189184977.1"
                     /transl_table=11
                     /translation="MPTDQLNGLPGLPGLPGLPGLPGLPGLTGLIGLFAEENRVRAFAA
                     VALGADTPAQVMEKAGLSPKDATVALRRLQDQGVITEDAGGLGVAYGRFRELARAAQAA
                     PPDEDYGSGDEQTEAVLRTFVREGRLVRLPAQWERKLVVLRHIAEQTFEPGVEYPERTV
                     NEKLRAWCEDTPVDHVTLRRYLVDLHHLHRQYGFYWRPEQHTQA"
     gene            complement(7768..8727)
                     /locus_tag="IEY95_RS06905"
                     /old_locus_tag="GCM10011579_013990"
     CDS             complement(7768..8727)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010468355.1"
                     /locus_tag="IEY95_RS06905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_013990"
                     /product="D-2-hydroxyacid dehydrogenase family protein"
                     /protein_id="WP_189184978.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.1e-53, bitscore:
                     176.9, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLRCAVLDDFQGVATEMADWSPIADEVEVVSFGNHFTDEDTLAV
                     ALADFDIVVTLRERVPFPASLLARLPRLRLLIASGMRNTVIDYAAAEAHDVTVCGTPSS
                     STPPVELTWALLLGLARGIVTENDALRAGGPWQSTVGADLHGRRLGLLGLGKIGGKVAQ
                     VGLAFGMRVCAWSQNLTKERAEEVGVEQAASKEELLASSDFVSVHLALGDRTRGLIGAA
                     ELALLKPTAYLVNTSRSAIVDQDALLAALHGGRIAGAGVDVFDIEPLPADHPMRSAPRL
                     LATPHLGYVSRANYETYYSAAVEDIQAFLAGTPVRRLG"
     gene            8855..9442
                     /locus_tag="IEY95_RS06910"
                     /old_locus_tag="GCM10011579_014000"
     CDS             8855..9442
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019059047.1"
                     /locus_tag="IEY95_RS06910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_014000"
                     /product="hypothetical protein"
                     /protein_id="WP_189184979.1"
                     /transl_table=11
                     /translation="MSASLTVRSLRAAVFAVLCVLLAAGGHGMSTGEAPPLWADGAGFL
                     AVFAAGCLLGGRERSLLGIGGGMLAAQAGLHLGFEAARPRMAMNMHGAHMMHPHAHALT
                     PHATAAHVTAALLATWWLRSGEAALWSLLRWAVALVPGLAAWWRVRTGPSPARAHQDVV
                     RRNAFETWPPRQVLLRHAVSRRGPPAGLAYTP"
     gene            9473..10219
                     /locus_tag="IEY95_RS06915"
                     /old_locus_tag="GCM10011579_014010"
     CDS             9473..10219
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006373485.1"
                     /locus_tag="IEY95_RS06915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10011579_014010"
                     /product="YcnI family protein"
                     /protein_id="WP_189184980.1"
                     /transl_table=11
                     /translation="MSPNRTTLRRAGLVAALTTAGVLTAAGAAFAHVTVHPESYAKGAT
                     DGVLTFRVPNEEDTASTTKVQVFLPTDHPVLGVLVTPQSGWTAKVTTTKLKTPIKTDDG
                     TITDAVSEITWTGGRIRHGEFQDFNVAFGQLPDDTDQLEFKTLQTYSDGNVVRWIEETP
                     KGGEEPESPAPVLTLTAKAAGEDSSEEPSGTDSSSSSGSAAKSSAASSKSSDSTARGLG
                     IAGLIVGVLGLAAAGFALARGRTARS"
     gene            complement(10305..>10460)
                     /locus_tag="IEY95_RS06920"
                     /pseudo=""
     CDS             complement(10305..>10460)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673879.1"
                     /locus_tag="IEY95_RS06920"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="HoxN/HupN/NixA family nickel/cobalt transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="VLHDKLDLRDDVTGWIAGLDLDNVGYIIVGLFVVVWVAAVAYWRL
                     ARVEQR"
ORIGIN
        1 cggtgacgtg cgttccgtcg gcgagctgcg ctctcaccag gtccgtcacc acccgggcga
       61 caccgccgtc gacgggctgg gtgatgtgga ggacccgcgg gggaggggcg gttgacagtt
      121 gcatgcgcgg ttcctccctc acgggcggcg cgcggcggcg cgcgtcactg cttcgcgtcg
      181 gcggcggcga acagtgcccc gccccgggcc gtgtcccgct gcgaagcgag tcggaggggg
      241 gccgccaggc gggcggggag aggagtcgta cggcagctga tgggagagtg ggccgcccct
      301 acgattccgc cgtgccggag tgcgtggtgc tgctgcgtga aggcgaggct ctccgcctcc
      361 ccgggcggcg cggccatcgc ggggccgccc ggcgcgcagc gggcggcgag gacggagcag
      421 cccaccatcg cacggcgcat cggaagaccc ggggaatgac gcatgaccgg cggtgccctt
      481 tcgggggaaa aaggttctgg accagcggac gaaccgaaat ctgcagatca catatgtgcg
      541 cgttgactcc ccgtctgttt ccgacgtccg ccgacgcctg tttctcatca gtctcgggag
      601 gagcccgact ctagccgcta tccgtattta tcggtgaaac cgaatcaagt gtgtcggaat
      661 ggtgaatctc ggcggtttgc gagatcactc ctttggaggc acaacccgca cgtgggccgc
      721 gcgttgattt cagagccggg caccccgccc ggatgttgtg tcgactccca aggagcactt
      781 ctccatgtcg cgtatcgcga agggcctggc cctgacctcc gttgccgctg ccgctgtggc
      841 gggcaccgcc ggcatcgccg ccgccaacag cgacgcacac ggcgccgctg cctactcccc
      901 gggcgtcgcg tcgggcaacg tcgttgaggt tcccgtccac gttccggtca acctctgcgg
      961 aaacaccgtc gacgtcatcg ccctgctgaa ccccgcgttc ggcgagacct gcggcaacgg
     1021 ctgacgtcag cgcggaccct tcggccggcc gtcctcccaa cgggagggcg gcctgttggt
     1081 gttgccccga atggagggag ctgggtgtca tcgcccggca tggcttctca ccagggacga
     1141 cggcggtggt aagggcgccc ggccgctacg tggagcaatc gaacggttgc aggccgcgac
     1201 gtgggctttc acggtgaaca caagatccga cgtcgttgag cgcaagctcc gacgcaccat
     1261 cgaagggaac atccatgcgt gctctgcccg cacggcgcat cgcgacctcc gctctctgcg
     1321 ccacgctgct gatcgggatc gccacacccg ccgccctggc ggcggacagc gactcgacgc
     1381 gtggccgcag tcatgcggcg gcccccgtac ccggcgcaga cgcgctgctt gcgcaggtcc
     1441 agtccctggc cgacataggc ggcgtactga ccccggtcac cgagctggtg gccgcagcac
     1501 tcaaggcgga caacggccag ctctccgccg acgatgcggc gaagctcggg caggccgtga
     1561 aggacgcgat cgccaaggtc accgcggcgg ctccggtgac gccgccggtc gccctcccga
     1621 cgacgccgcc gacgacgctg cccaccacgg cgccgaccgt gacgaaggag cccacaacgc
     1681 cgaccacgtc gacgctcccg gcgacgaaga acgccgatca ccgggacggc aaggcgcgtg
     1741 gtgccgacgg gccgcgcgcc gaggctccgg cggacctcaa gggcgacgcc ctgaccgccc
     1801 ttcagaaggc ggtcgacacg ctgctcaagg cggtcacgtc gggcgacccc accggggtgg
     1861 ttcccgcggc caccgcggtg gtgacgggtc tcgtcaactt cgtcgtcgcc acggtgctcg
     1921 gcggtggtct gccggcggcg aacctgcccg gtctgccgag cctgccgagc acgctgccga
     1981 cgagttcact cccgacgtcc ggtcttgtgc ccacttcctg agcacgggga gcggtctgag
     2041 gcgaagcagt cgccaccctg ccgtcgtgcc gaccatcctg gtcggcacga cggctgtttg
     2101 tcatggggcc ctgggcctga ggccttgggc gtgcgtcagg tcatgggtgc gggttcttgt
     2161 atgagaatgc gacacgccgt tcgttcgggt ggggcgcagg gaatttcagc actcggggtt
     2221 tccgcagtgt ccggggctcg ttagtcgacg catagaggaa ttccctctgg tgacatgagt
     2281 tgccgaagaa aggaacacga tgaagtccct gaaggccgcc gctgtcgtcg ccgggtccat
     2341 ggtcatcgct ggtgccgcca cgcccgcctt tgccgccgag gcctccgacc tgacgccctc
     2401 cagcctcaac ggcgccgtgg agaccatcac cagccagcgc acgctcaatg tggaagacgt
     2461 gatgccgctg cagcaccagt cgaaggcgct cgacaccgag aacaagggct ccctgctcaa
     2521 cgccgtgagc ggcgcgacga aggcgctcaa cacgaccggt ggccccgcgc gactgctcgg
     2581 cggacttccc cttcagagct aatcggttca tttcatcgcg tgtctttcca caagggctgc
     2641 gggcatttcc ctaggctctg gagcaaatct cccaggaaag ggctgacgat gaacactgtg
     2701 aagaagatcg ctcttatttt cgccgccgcc ggaatcgccg cgggtgccgc gtccggcgcg
     2761 gccttcgccg acaccggtgc cgacgccgcg gcgctcacgt ccccgggtgt cgtctccggc
     2821 aacgtcattc agatccccgt gcacgttccg gtgaacctct gcggcgactc ggtcgacgtc
     2881 atcggcctac tgaaccccgc gggcggcacc tcctgcacca accactgacg acgtcctgcg
     2941 cattccgaaa gggctgattc cgtacccaac ggagtcggcc ctttcgcgct gttcgaaaag
     3001 ggtccctcgt tcgtgtggtc ggtcgccggg gcatcgcccg ggcgggtgag gaaagggccg
     3061 ggctctttcg ggcgcgtcga taaggttccg cggtgacctc aacctcaagc gaaacgcgcc
     3121 catttcgggt cgccgatctc ggcacgctcg ccgtcatggc cttcagcggt gatgcgcccg
     3181 acggcgacat gccctatctc ctggcctact ccctgggcga cgccgagggc ggaccggagg
     3241 gcacctcggc cgccatcgag cggctgctga ggaagaacgg tctgcccgtc ggcgaccggc
     3301 tcatcgacgg ctcccgacgt ccgagcctgc cgctcgccct cctcgtggag gcgggccagg
     3361 ccgtcgtcac catgccggcg tacctgaagg cccagtgcgt cgcgccgccc gagtggctcg
     3421 ccgcggtcgg cgaacgcggc tacgcctact tcctgttcgc cacccgcgcc tggcccgagg
     3481 ccacgcccgg caagcccgtc gcaccggaga gcctggccgc cttcgccggt gacgaggaga
     3541 ccctgctgag cgcggcacat gtgctgctgc ccgtgcgcaa cctgcgcagc tgatgacatc
     3601 caccgcgggg cggacggcgg gcggcgacgg tgcggtcgtg ccgaccgtgg gcggcagccg
     3661 ggcgttcgcc ctgctgctgg tgatcaccgg tgcggccggt ctcctggccg cgtgggtcat
     3721 cacgatcgac aagttcaagc tgctggagaa cccgaacttc gtgcccgggt gcagcctgaa
     3781 cccggtcgtc tcctgcggca acatcatgaa gagcgagcag gcctcggcct tcgggttccc
     3841 caacccgatg ctgggcctgg tggcctacgg catcgtcatc tgcgtcggca tgagcctgct
     3901 cgcccgggcc accttcccgc gctggtactg gctgaccttc aacgccggca cgctcttcgg
     3961 ggtcggcttc tgcacctggc tgcagttcca gtcgctctac cgcatcaacg cgctgtgcct
     4021 gtggtgcagc ctcgcctggg tcgccacgat catcatgttc tggtacgtga catcgctgaa
     4081 cgtacgacat gaattcctgc ccgcgccgga ctggttgagg gggttcctcg gggaattcac
     4141 ctgggtcctg ccggtcgtgc acatcggcgt catcggcatg ctgatcctga cgcgctggtg
     4201 ggatttctgg accagctgat tttccgaaca attcgattgt cccacgaacc gactattggg
     4261 tccgtcgggg gaatcttgaa ctgatggcga tctcaggatc gttacgcggg tacggacgct
     4321 gagcccccga attctgaaag ggaccgtacc tgagatgaag ccgaccacac gaggaactct
     4381 tgccgccgtc atgaccggtg tcgcggcaac gatgggcgcc gccgtcgcga cccccgccgt
     4441 cgcggccggg acggtccccg ttcccgtacc gctggacggt gtggagaacg ccctcaacgt
     4501 gaaggcaccc aagatctccg gggagctgcc ggttcccatg ccgggcgggc cccgggggcc
     4561 tcggtacgtc gagggcaggc tgatcccgga gcacgtcctg ccgcagctgc ccgtcaacgg
     4621 agggctgccc ggggcgaacg tccacacccc ccttccgcat gtcctcgggg acggcttcga
     4681 ccacttcggt gtcggtgcgc ccgcggccga cctgaggacg ctgacgcccg ggctgtccct
     4741 ggacaccccg ctcaccgcac ccaaagccga ccacttcggc ctcccggacg cgaagctccc
     4801 tcaggtcgcc gtactcaccc cgctgttgaa gaccgtgccc gcggcgaacc tggacatggg
     4861 ggcgggtgcg tagccgcagc catgggcgag gccctggtct tcggcccggg cctgccgccg
     4921 gttccgccgc cggcatcacc ggcggccgct gggggccgcc gtcaccgaac ccgacccgat
     4981 tccgccgagg agagagagcc atgtccgtca gtagggcgtc gagcagcgtg tcgagcaaag
     5041 tgccgaggag cgtgtcgagc ggcgtttcgg tgacccgccg gggtgcgatg cgcggcctgc
     5101 tcgtatcggc gttcgccgtg gcgctgactc ccgtcgtcgc ggcctcgcgg ccgccgcgtg
     5161 agacccgtca ggaggaccct tcgttcgacg aggtgtaccg cggccggcac atcctcggca
     5221 cgaggaccgg cacggacgcc cgggcctcgt tcgacggggg ctatgacagg ggctacggcg
     5281 ggggccatag cggcggaccc gggggcagcg agtggcatgt caccgtcgac ggcaagccgt
     5341 tgcagctgat gcgccgtgcg gacggcagct atctcagcat ggtggaccac tatgagtcgt
     5401 atccgacggc gctcgccgcg gtgcgcgcgg ctgtggacga gctcggtccc tcggagcacc
     5461 tgcgtggcat ggacgcggcg gggagtgaca cggaggggag cagctaccgc catggcgtac
     5521 acgcgtaagg acgtcagcaa gctgaccggc gcggagcggc gccgcttcgt cgccgcgatg
     5581 ctggaggtca aacgcagggg cgagtacgac gagttcgtcc ggatgcacat cgagtactac
     5641 gtcgcggacg gcgacggtgg actgcgtacg gcccacatgg cgccctcctt cctgccctgg
     5701 caccgtcggt tcctgctgga cctggagcgg gcgctgcgcc gggtcgactc cggggtgagt
     5761 gtgccgtatt gggactggac gcggcaccgc accacgacgt ccgtgccgtg gaccaacgat
     5821 ctgctcggcg gcaacgggcg gcgctcggac cggcaggtca tgaccgggcc cttcgcctat
     5881 gcgcacggga agtggacgat cagggagggg gtgaccgacg gcgagtttct caggcgcgag
     5941 ttcggccgcc cgctggatcg gatcgagctg cccacgaaga aagagctgga atccgctttg
     6001 aaggatcccg tctacgacac ggccccttgg aactccacgt ccaccggagg gttccgcaac
     6061 aagctcgaag ggtgggggca cggttccggc agcgccgcct ggcgcaacca caaccgcgtc
     6121 caccgctggg tcggcgggca catgctcggt ggtgcctcgg tcaacgaccc ggtcttctgg
     6181 ctgcaccacg ccttcgtgga cctcctgtgg gaccgctggc agcagcggca ccgcggcgcg
     6241 cgctatctgc ccgcgcgacc gccggcaccg ggcgactcac agcaccgccg ggtcgtcgca
     6301 cggcacgaga agatgccgcc gtggggcgag accccgggcg cccaggagca ccacagcagg
     6361 atctaccggt acgcgtagga cggcggctgt gctctcagca cggcgaggcc cccggcagac
     6421 tcctgccggg ggcctcgcga ggcgcgcacg tgggtcagtt gccatacccg tagccctcgc
     6481 gctcctggcc ttggtcgtcg tagttcccgc agtggtcgcc gaaggccggg ttcagcaggc
     6541 cgatgacgtc ggcggtgttc ccgcacacgt tgaccggcac gttgatcggg acctgaacgg
     6601 cgttgcccga aacgacgcct ggcgagccga cggcctcgcc ctgagcgccg gtgttcgcca
     6661 tggccaggcc ggccccgctg agcaccacgg cacccgtgcc ggcggcgaca acggcggctt
     6721 tcgcgatgcg agacatcacg ttctcctttg agtcgataag tgtggctgca cggacgcgac
     6781 cgcactcccc cttcaacgcc cccacccaca cctggtcacg gcgttcatct ggggatcact
     6841 ctttccgaag aggccatttt cgtccggctg acgtgtcgcg ggcggaaatt cacttcggtc
     6901 ggctgcctgg cctcaactag cctgccgggc atgccaaccg accaactgaa cggcctgcct
     6961 ggcctgcctg gcctgcctgg cctgcctggc ctgcctggcc tgcctggcct gacgggcctg
     7021 atcggcctgt tcgccgagga gaacagggtc cgtgccttcg ccgccgtggc cctcggcgcg
     7081 gacacccccg cgcaggtcat ggagaaggcg gggctgtccc cgaaggacgc gacggtggcg
     7141 ctgcggcggc tccaggacca gggcgtgatc acggaggacg ccgggggact gggcgtcgcc
     7201 tatggtcgtt tccgggagct cgcgcgtgcc gcgcaggcgg cgccgcccga cgaggactac
     7261 ggctccgggg acgagcagac cgaggcggtg ctgcggacct tcgtgcgcga ggggcgcctg
     7321 gtgcggctgc ccgcccagtg ggagcgcaag ctcgtcgtgc tccggcacat cgccgagcag
     7381 accttcgagc cgggcgtcga gtacccggag cggaccgtca acgagaagct gcgcgcctgg
     7441 tgcgaggaca cgccggtcga ccatgtgacg ctacggcggt acctcgtgga tctgcaccat
     7501 ctgcaccggc agtacggctt ctactggcgt cccgagcagc acacgcaggc gtgaccggga
     7561 gagcgcggcg taccgagtgc cgggcggctc gtccgaggcg gggcaagagc gtgcccgctg
     7621 gatcggggcg acgtaccggc gtgtcccgtg gccggggcgg cgtttcggtg ggtccgcgtg
     7681 gccggggcgg tgtgtcggtg ggttcgcgtg gccggggtgc tgtgtcggtg tgcccgctcg
     7741 gccgatatgg cctaccggcg tgtccggtca gccgaggcgg cgtacgggcg tgcccgccag
     7801 gaacgcctgg atgtcctcga ccgccgcgct gtagtacgtc tcgtagttgg cccgcgacac
     7861 atagccgagg tgcggggtgg ccagcaggcg cggggccgag cgcatcgggt ggtcggcggg
     7921 gagcggctcg atgtcgaaca cgtcgacacc cgctccggcg atccgtccgc cgtgcagcgc
     7981 ggcgagcagt gcgtcctggt cgacgatcgc cgaccgtgaa gtgttgacga ggtaggcggt
     8041 cggcttgagg agggccagtt cggcggcgcc gatcaggccc cgggtgcggt cgccgagcgc
     8101 gaggtggacg gagacgaagt cgctgctcgc gagcaactcc tccttggagg cggcctgctc
     8161 cacccccact tcttcggcgc gctccttggt gaggttctga ctccacgcgc agacccgcat
     8221 gccgaaggcg aggccgacct gtgccacctt gccgccgatc ttcccgaggc cgagcagacc
     8281 gagccggcgg ccgtgcagat cggcgccgac ggtgctttgc caggggccgc ccgcccgcag
     8341 cgcgtcgttc tccgtgacga tgccccgcgc gaggccgagc agcagcgccc aggtcagctc
     8401 gaccgggggt gtcgaggagc tcggggtgcc gcacacggtc acatcgtgcg cttcggcggc
     8461 cgcgtagtcg atcaccgtgt tgcgcattcc ggaggcgatc agcagtcgca gtcgcggcag
     8521 tcgggccagc agcgaggcgg ggaagggcac ccgctcgcgc agggtgacga cgatgtcgaa
     8581 gtccgcgagt gcgacagcca gcgtgtcttc gtccgtgaag tggttgccga agctcacgac
     8641 ttccacctcg tccgcgatcg gcgaccagtc cgccatctcg gtcgcgacgc cctgaaagtc
     8701 gtccagcacg gcacagcgaa gttgcatgtc aggtccctcc cacgctcagc cggaccctac
     8761 ccgagccagg aaagcgcacc cgggccgccc gggagaggcg gctccggggg aagcggccgc
     8821 ggacgctcgc tccccgtggc agtatctggg ctccatgagt gcgtccctga cagtacggag
     8881 cctgcgcgcg gcggtgttcg ccgtgctgtg cgtgctgctg gccgccggcg ggcacgggat
     8941 gtcgacgggc gaggcgccgc cgctgtgggc ggacggtgcc gggttcctcg ccgtcttcgc
     9001 ggcaggctgt ctgttgggcg gccgggagcg gtcgctgctc gggatcggcg gcggaatgct
     9061 ggccgcgcag gccggactcc acctcgggtt cgaggccgcc cgcccgcgca tggcgatgaa
     9121 catgcacggg gcgcacatga tgcacccaca cgcacacgcc ctgacacccc acgccacggc
     9181 cgcgcatgtg accgccgccc tgctcgcgac ctggtggttg cggtccggcg aggccgcgct
     9241 gtggtctctg ctgcggtggg ccgtggcgct cgtgccgggg ctcgcggcgt ggtggcgggt
     9301 gcggacgggg ccgtctcccg cacgggccca tcaggacgtc gtacgccgga acgcctttga
     9361 gacgtggccg ccgcggcagg tgttgctgcg gcacgccgtc tcccgtcggg gaccgccggc
     9421 cgggctcgcg tacacgccct gaccgcatcc acaccagtac ggagttcccc cgatgtcccc
     9481 gaatcgcacc accctgcgcc gagccggcct cgtcgccgcc ctcaccacgg ccggagtcct
     9541 gaccgccgcg ggcgccgcct tcgcgcatgt gacggtccat cccgagagct acgccaaggg
     9601 cgccacggac ggtgtgctga ccttccgcgt ccccaacgag gaggacacgg ccagcaccac
     9661 gaaggtgcag gtcttcctgc ccaccgatca tccggtcctg ggtgtcctgg tcactccgca
     9721 gtccggctgg accgcgaagg tgacgaccac caagctcaag acgcccatca agaccgacga
     9781 cggcacgatc accgacgccg tctccgagat cacctggacc ggcggcagga tccgccacgg
     9841 cgagttccag gacttcaatg tcgctttcgg tcaacttccc gacgacaccg accagttgga
     9901 gttcaagacg ctgcagacct actcggacgg caatgtcgtc aggtggatcg aggagacacc
     9961 gaagggcggc gaggagccgg agagcccggc gccggtgctc acgctgaccg ccaaggccgc
    10021 gggggaggac tcctccgagg agccgtccgg cacggactcg tcgtcgagtt ccggatcggc
    10081 tgccaagagc tcggccgcga gcagcaagag cagtgactcg accgctcgcg gcctcggcat
    10141 cgccggcctc atcgtgggcg tcctcggcct ggccgcggcc ggattcgccc tcgcgcgggg
    10201 ccggaccgcc cgctcctagc cgggaagcgg gggcggctgc cacccaagtc gatgggcggc
    10261 tgccgccccc gccggtctca actcccgtcg gcggggcgga ccgcctaccg ctgctcgacc
    10321 ctggccagcc gccagtacgc cacggccgcg acccagacga ccacgaacag gccgacgatg
    10381 atgtacccga cgttgtccag gtcgagcccc gcgatccagc cggtcacgtc gtcgcgcagg
    10441 tcgagcttgt cgtgcagcac gcggggtccc ctcgccgtct ccgacctcgc cgtcgcgacc
    10501 ggtatgaacg accccgccgt gtcccagg
//
