Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP061033.1 (Corynebacterium zhongnanshanii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | NAPAA | 321,027 | 355,043 |
Region 2 | terpene-precursor | 738,524 | 759,678 |
Region 3 | terpene | 982,462 | 1,003,631 |  |
Region 4 | RiPP-like | 1,260,064 | 1,270,381 |
Region 5 | terpene,T1PKS | 1,820,222 | 1,875,282 | Low | TP-1161 | ribosomal:RiPP:Thiopeptide
Region 6 | lanthipeptide-class-ii | 2,069,500 | 2,099,361 |

NZ_CP061033.1 - Region 1 - NAPAA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 321,027 - 355,043 nt. (total: 34,017 nt) Show pHMM detection rules used
NAPAA: (AMP-binding and TIGR02353)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deacetylase deformylase
IAU67_RS01375: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

IAU67_RS01400: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Ligases: ligase
IAU67_RS01390: carboxylate-amine ligase

smcogs
  SMCOG1165: carboxylate-amine ligase

IAU67_RS01415: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAPAA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002174.2 |  | 0.76 | NRPS | ε-Poly-L-lysine | Epichloe festucae
BGC0001135.5 |  | 0.61 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.60 | NRPS | enniatin | Fusarium equiseti
BGC0001251.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001641.4 |  | 0.60 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000307.4 |  | 0.59 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0002286.3 |  | 0.59 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002174.2 |  | 0.76 | NRPS | ε-Poly-L-lysine | Epichloe festucae
BGC0001135.5 |  | 0.61 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.60 | NRPS | enniatin | Fusarium equiseti
BGC0001251.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001641.4 |  | 0.60 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000307.4 |  | 0.59 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0002286.3 |  | 0.59 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.09 out of 30.22
Confidence: medium
Additional weak hits (12):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.55 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.05 out of 26.06
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.06 out of 21.55
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.82 out of 23.43
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.10 out of 27.78
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.74 out of 26.85
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.00 out of 26.06
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.94 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.06 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.84 out of 30.25
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.37 out of 30.11
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.18 out of 28.19
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 321026 - 355043:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
IAU67_RS01415: X
AMP-binding (22..407): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAELFDASCEELSTIFGGEWNTYGPTEATVVACG
  Nearest Stachelhaus code(s):
    Lys DAEDIGTVVK (71% 8Å match)
    Gln or Tyr DAESVGTVVK (65% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ClgR | Caseinolytic protease gene regulator

NZ_CP061033.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 738,524 - 759,678 nt. (total: 21,155 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
IAU67_RS03320: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Transferases: acyltransferase
IAU67_RS03290: acyltransferase

smcogs
  SMCOG1141: acyltransferase

Ligases: synthetase
IAU67_RS03325: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.3 |  | 0.45 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001456.3 |  | 0.42 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.41 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3 |  | 0.40 | terpene | carotenoid | Streptomyces avermitilis
BGC0000649.3 |  | 0.38 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000936.5 |  | 0.37 | other (other) | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0001910.4 |  | 0.36 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.3 |  | 0.45 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001456.3 |  | 0.42 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.41 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3 |  | 0.40 | terpene | carotenoid | Streptomyces avermitilis
BGC0000649.3 |  | 0.38 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000936.5 |  | 0.37 | other (other) | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0001910.4 |  | 0.36 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
IAU67_RS03325: PT_FPPS_like
Domain 1 (54 - 382): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (4):
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.74 out of 21.84
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.62 out of 26.06
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 35.63
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP061033.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 982,462 - 1,003,631 nt. (total: 21,170 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
IAU67_RS04460: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001226.4 |  | 0.41 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001779.5 |  | 0.41 | ribosomal | siamycin | Streptomyces nodosus
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001660.3 |  | 0.40 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001862.4 |  | 0.40 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000501.3 |  | 0.40 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001579.4 |  | 0.40 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001226.4 |  | 0.41 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001779.5 |  | 0.41 | ribosomal | siamycin | Streptomyces nodosus
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001660.3 |  | 0.40 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001862.4 |  | 0.40 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000501.3 |  | 0.40 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001579.4 |  | 0.40 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
tetraterpene | C40 carotenoid |  | C40 | unknown | unknown

Genes with terpene domains:
IAU67_RS04445: Lycopene_cycl
Domain 1 (3 - 332): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.89 out of 20.97
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.31 out of 23.79
Confidence: medium
Additional weak hits (5):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.73 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.47 out of 26.06
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.37 out of 36.53
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.40 out of 26.06
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
IolR | Regulator of the inositol catabolism

NZ_CP061033.1 - Region 4 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,260,064 - 1,270,381 nt. (total: 10,318 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001699.4 |  | 0.36 | NRPS | nidulanin A | Aspergillus nidulans FGSC A4
BGC0000487.5 |  | 0.36 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.35 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002289.2 |  | 0.33 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001699.4 |  | 0.36 | NRPS | nidulanin A | Aspergillus nidulans FGSC A4
BGC0000487.5 |  | 0.36 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.35 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002289.2 |  | 0.33 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (4):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.13 out of 30.22
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.37 out of 26.06
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.32 out of 21.55
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.24 out of 32.38
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP061033.1 - Region 5 - T1PKS,terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,820,222 - 1,875,282 nt. (total: 55,061 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
IAU67_RS08205: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

IAU67_RS08290: nucleotide sugar dehydrogenase

smcogs
  SMCOG1152: nucleotide sugar dehydrogenase

Transferases: acyltransferase transferase
IAU67_RS08305: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

IAU67_RS08365: acyltransferase

smcogs
  SMCOG1141: acyltransferase

Hydrolases: back translocase esterase hydrolase
IAU67_RS08215: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

IAU67_RS08220: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

IAU67_RS08330: putative esterase

smcogs
  SMCOG1104: putative esterase

IAU67_RS08335: putative esterase

smcogs
  SMCOG1104: putative esterase

IAU67_RS08360: hydrolase

smcogs
  SMCOG1179: hydrolase

Ligases: ligase synthase
IAU67_RS08300: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

IAU67_RS08310: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

IAU67_RS08315: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001276.3 |  |  | 0.30 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001273.3 |  |  | 0.30 | PKS | asperlactone | Aspergillus ochraceus
BGC0001275.3 |  |  | 0.30 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001244.3 |  |  | 0.30 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0002175.3 |  |  | 0.29 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0001164.3 |  |  | 0.29 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0000107.3 |  |  | 0.29 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0001258.3 |  |  | 0.29 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Glarea lozoyensis
BGC0001160.5 |  |  | 0.29 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0002154.2 |  |  | 0.29 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001273.3 |  | 0.64 | PKS | asperlactone | Aspergillus ochraceus
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001163.3 |  | 0.64 | PKS | 1-heptadecene | Moorea producens 3L
BGC0001162.3 |  | 0.64 | PKS | 1-heptadecene | Moorea producens JHB
BGC0001161.5 |  | 0.64 | PKS | 1-heptadecene | Moorea bouillonii PNG
BGC0002175.3 |  | 0.63 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0001164.3 |  | 0.63 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0000107.3 |  | 0.63 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | PSPP | C30 | acyclic | PP
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | squalene | C30 | acyclic | none
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
IAU67_RS08245: PT_phytoene_like
Domain 1 (32 - 317): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → PSPP
  FPP → diapophytoene
  FPP → squalene
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.60 out of 29.72
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.58 out of 27.78
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.42 out of 19.52
Confidence: strong
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52
Confidence: medium
Additional weak hits (18):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.86 out of 30.25
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.53 out of 26.85
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.45 out of 30.97
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.40 out of 36.53
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.89 out of 25.75
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.81 out of 20.01
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.89 out of 20.01
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.72 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.51 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.96 out of 28.14
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.22 out of 28.14
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.66 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.28 out of 26.06
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.55 out of 27.18
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.59 out of 29.65
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 30.98
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 1820221 - 1875282:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 1830239 - 1875282:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (pk)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
IAU67_RS08300: X
AMP-binding (69..468): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    QWRH----WGWVITVSSGNCNFYGSTENSVVSIA
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

IAU67_RS08310: pk
PKS_AT (651..954): pk
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 58.3%

minowa: fatty_acid

Prediction, score:
  fatty_acid: 106.3
  Malonyl-CoA: 88.3
  Methoxymalonyl-CoA: 79.5
  Methylmalonyl-CoA: 77.1
  Ethylmalonyl-CoA: 54.8
  Propionyl-CoA: 53.3
  Isobutyryl-CoA: 50.2
  2-Methylbutyryl-CoA: 45.0
  Acetyl-CoA: 41.6
  trans-1,2-CPDA: 36.1
  CHC-CoA: 24.1
  Benzoyl-CoA: 16.1
  3-Methylbutyryl-CoA: 14.2
  inactive: 12.6

IAU67_RS08315: Acetyl-CoA
CAL_domain (65..527): Acetyl-CoA
minowa: Acetyl-CoA

Prediction, score:
  Acetyl-CoA: 31.1
  fatty_acid: 15.9
  NH2: 5.9
  shikimic_acid: 5.8
  AHBA: 4.4

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
NtrC | Nitrogen regulatory protein C

NZ_CP061033.1 - Region 6 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,069,500 - 2,099,361 nt. (total: 29,862 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
IAU67_RS09330: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

IAU67_RS09350: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002110.3 |  | 0.55 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000552.3 |  | 0.53 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000497.3 |  | 0.52 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000590.5 |  | 0.51 | ribosomal | microcin N | Escherichia coli
BGC0000517.4 |  | 0.50 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.50 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000520.5 |  | 0.49 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000626.3 |  | 0.49 | ribosomal | thuricin | Bacillus thuringiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002110.3 |  | 0.55 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000552.3 |  | 0.53 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000497.3 |  | 0.52 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000590.5 |  | 0.51 | ribosomal | microcin N | Escherichia coli
BGC0000517.4 |  | 0.50 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.50 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000520.5 |  | 0.49 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000626.3 |  | 0.49 | ribosomal | thuricin | Bacillus thuringiensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for IAU67_RS09330

IAU67_RS10055
Leader:
MTCLGFMCKIHAG
Core:
L M I L A A V R Q V L P A P S W Q R C R T H F A K N P S L K V L K Y Q W T A P S V K I R R W R Q Q F H I R K T S G
Core with dehydrations:
L M I L A A V R Q V L P A P Dha W Q R Cys R Dhb H F A K N P Dha L K V L K Y Q W Dhb A P Dha V K I R R W R Q Q F H I R K Dhb Dha G

#### antiSMASH-DB 4.0 matches for IAU67_RS10055

21.1%
NZ_VMLD01000009.1 and 3 others:
NZ_VMLI01000004.1 Lanthipeptides: HT696_RS02300_lanthipeptide NZ_VMMD01000015.1 Lanthipeptides: HT711_RS05565_lanthipeptide NZ_VMMI01000027.1 Lanthipeptides: HT721_RS06685_lanthipeptide
Lanthipeptides: HT679_RS04550_lanthipeptide
5
A A V R Q V L P A P S W Q R C R T H F A K N P S L K V L K Y Q W T A P S V K I R
44
A +R + S R C F L Y+ T+P+V+ R
4
A G L R T A I R M T S Q G R C G W A F-------T L S Y E C T S P N V R C R
36
14.0%
NZ_BDHJ01000009.1:
Lanthipeptides: BHQ08_RS35915_lanthipeptide
6
A V R Q V L P A P S W Q R C R T
21
A+R L A P +R C T
6
A I R L G L K A P V N R R C E T
21
13.3%
NZ_CP022201.1 and 1 other:
NZ_LT629691.1 Lanthipeptides: allorf_5449102_5449314_lanthipeptide
Lanthipeptides: allorf_5398989_5399201_lanthipeptide
12
P A P S W Q R C R T H F A K N P S
28
P P+W R C T + P S
4
P N P N W G R C A T Q R E Q A P S
20
IAU67_RS09320
Leader:
MVKNAGIFEEISDQYVPEANAAGQGWGTLVTSLNCYGA
Core:
S W A L G N E G N F C T G T I E C Q K T C Q
Core with dehydrations:
Dha W A L G N E G N F Cys Dhb G Dhb I E Cys Q K Dhb Cys Q

#### antiSMASH-DB 4.0 matches for IAU67_RS09320

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: IAU67_RS09320_lanthipeptide
Lanthipeptides: IAU67_RS09320_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S W A L G N E G N F C T G T I E C Q K T C Q
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
50.0%
NZ_CKMQ01000043.1 and 10 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide
Lanthipeptides: AE832_RS11585_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S A L G N+G C T G T I E C Q C+
9
S E A L G N K G A V C T G T I E C Q N N C R
30
50.0%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS17475_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S L G N+G F C T T+E C +C
3
S S L L G N D G K F C T L T V E C M P S C N
24
with 103 more sequence matches
Only the first 10 are displayed here.
47.8%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide
Lanthipeptides: HBA49_RS00770_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S L G N G +C T T E C +C
2
S R L L G N N G R W C T I T K E C M P S C N
23
47.1%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide
Lanthipeptides: IE257_RS28650_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S W A L G N G+ C T T+E C Q K C Q
12
S W A L G N N G H L C T V T V E C Q K N C Q
33
46.4%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C
21
S A L G N G++C T T E C Q C
7
S A A L G N R G S Y C T L T K E C Q A C C
27
45.2%
NZ_GG657754.1 and 1 other:
NZ_GG657754.1 Lanthipeptides: SSOG_RS49055_lanthipeptide
Lanthipeptides: SSOG_RS49055_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C
21
S+ +G N G N F C T T+E C Q K C
10
S F V M G N L G N F C T A T L E C Q K N C
30
44.4%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C
21
S L G N G C T T E C Q+ C
6
S R K L G N T G Y V C T L T K E C Q R M C
26
43.2%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S W A L G N+G N F C T T+E C Q C+
16
S W A L G N D G N F C T A T V E C Q S N C K
37
42.9%
NZ_KE384107.1:
Lanthipeptides: G586_RS23925_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C
21
S +L G N G++C T T E C Q C
7
S A S L G N R G S Y C T I T K E C Q A C C
27
42.9%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
3
A L G N E G N F C T G T I E C Q K T C Q
22
+L G N+G C T T E C Q K C+
9
S L G N K G Y V C T L T K E C Q K L C R
28
42.3%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
4
L G N E G N F C T G T I E C Q K T C
21
L G N+G C T T E C Q C
8
L G N K G R I C T L T K E C Q S M C
25
41.4%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
4
L G N E G N F C T G T I E C Q K T C
21
L G N G F C T T E C Q +C
10
L G N T G Q F C T L T K E C Q P S C
27

#### MIBiG 4.0 matches for IAU67_RS09320

40.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
3
A L G N E G N F C T G T I E C Q K T C Q
22
A L G N G +C T T E C Q C
11
A L G N N G G W C T L T K E C Q P N C N
30
35.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
4
L G N E G N F C T G T I E C Q K T C Q
22
L G N+G +C T T+E C +C
10
L G N K G A Y C T L T V E C M P S C N
28
18.9%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
3
A L G N E G N F C T G T I E C Q K T C
21
A+G F C T +C C
20
A V G V S A A F C P-T T K C T S R C
37
with 1 more sequence matches
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
11
C T G T I E C Q K T C
21
C T + E C Q C
28
C T L S K E C Q P N C
38
IAU67_RS09325
Leader:
MHNYSASNGFISDEAMLQIIDANDASLSNQVAAGTTSPLCVVGGAVSAAS
Core:
A Y L D D A C P T S G C T H S C
Core with dehydrations:
A Y L D D A Cys P Dhb Dha G Cys Dhb H Dha Cys

#### antiSMASH-DB 4.0 matches for IAU67_RS09325

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: IAU67_RS09325_lanthipeptide
Lanthipeptides: IAU67_RS09325_lanthipeptide
1
A Y L D D A C P T S G C T H S C
16
A Y L D D A C P T S G C T H S C
1
A Y L D D A C P T S G C T H S C
16
50.0%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28640_lanthipeptide
Lanthipeptides: IE257_RS28640_lanthipeptide
7
C P T S G C T H S C
16
C P T S G C T C
1
C P T S G C T G R C
10
50.0%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17825_lanthipeptide
Lanthipeptides: KPP03845_RS17825_lanthipeptide
7
C P T S G C T H S C
16
C P T S G C T C
1
C P T S G C T K R C
10
with 67 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_GG657754.1 and 1 other:
NZ_GG657754.1 Lanthipeptides: SSOG_RS27835_lanthipeptide
Lanthipeptides: SSOG_RS27835_lanthipeptide
7
C P T S G C T H S C
16
C P T S G C T C
1
C P T S G C T S K C
10
47.1%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide
Lanthipeptides: DEI99_RS08060_lanthipeptide
1
A Y L D D A C P T S G C T H S C
16
A L C P T C T C
2
A A L P G F C P T G A C T S K C
17
43.8%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS31015_lanthipeptide
Lanthipeptides: CN325_RS31015_lanthipeptide
7
C P T S G C T H S C
16
C P T S C T C
3
C P T S K C T T R C
12
37.5%
NZ_BJTV01000004.1 and 5 others:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35800_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide
Lanthipeptides: TNCT1_RS35800_lanthipeptide
7
C P T S G C T H S C
16
C P T+ C T +C
4
C P T T K C T S A C
13
37.5%
NZ_JAGGRJ010000019.1:
Lanthipeptides: allorf_047072_047179_lanthipeptide
4
D D A C P T S G C
12
D D A P G C
2
D D A Q P V P G C
10
30.8%
NZ_JALAPU010000003.1 and 7 others:
NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide
Lanthipeptides: MOD17_RS07925_lanthipeptide
1
A Y L D-D A C P T S G C T H S C
16
A Y+ + C P T+ C T +C
10
A Y I S S N T C P T T A C T R A C
26
29.6%
NZ_KE384533.1 and 2 others:
NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide
Lanthipeptides: K329_RS31315_lanthipeptide
1
A Y L D-D A C P T S G C T H S C
16
A Y+ + C P T+ C T C
11
A Y V S T N T C P T T S C T D E C
27
28.6%
NZ_CP115450.1 and 1 other:
NZ_CP115450.1 Lanthipeptides: O1G21_RS35405_lanthipeptide
Lanthipeptides: O1G21_RS35405_lanthipeptide
7
C P T S G C T H S C
16
C P T+ C T C
12
C P T T A C T S R C
21
28.6%
NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide
Lanthipeptides: BUE45_RS13105_lanthipeptide
1
A Y L D D A C P T S G C T H S C
16
A D C P T+ C T C
13
A A W G D G C P T T V C T S R C
28
28.1%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
1
A Y L-D D A C P T S G C T H S C
16
A Y+ D C P T+ C T +C
16
A Y V S D K T C P T T A C T R A C
32

#### MIBiG 4.0 matches for IAU67_RS09325

23.1%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
7
C P T S G C T H S C
16
C P T+ C T C
17
C P T T K C T S K C
26
16.2%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
7
C P T S G C T H S C
16
C P T+ C T C
28
C P T T K C T S R C
37
IAU67_RS09375
Leader:
MWARALKACRDHIDDEGGMSTIEYA
Core:
L G C V A A A A L G A L L Y T V V T S G A V E D A L R G I F E R A L N E G G K
Core with dehydrations:
L G Cys V A A A A L G A L L Y Dhb V V Dhb Dha G A V E D A L R G I F E R A L N E G G K

#### antiSMASH-DB 4.0 matches for IAU67_RS09375

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: IAU67_RS09375_lanthipeptide
Lanthipeptides: IAU67_RS09375_lanthipeptide
1
L G C V A A A A L G A L L Y T V V T S G A V E D A L R G I F E R A L N E G G K
39
L G C V A A A A L G A L L Y T V V T S G A V E D A L R G I F E R A L N E G G K
1
L G C V A A A A L G A L L Y T V V T S G A V E D A L R G I F E R A L N E G G K
39
23.1%
NZ_CP033932.1 and 1 other:
NZ_CP084347.1 Lanthipeptides: KB553_RS11820_lanthipeptide
Lanthipeptides: EG339_RS01270_lanthipeptide
2
G C V A A A A L G A L L Y T V V T S G A V E D A L R
27
G C A A G + T+ A E D +
11
G C D A T A V C G C V T Q T I K K P K A F E D G I E
36
allorf_2069703_2069807
Leader:
MISRGGTRGVAGDIATG
Core:
H A H Q D G G V A C C S C V L T R
Core with dehydrations:
H A H Q D G G V A Cys Cys Dha Cys V L Dhb R

#### antiSMASH-DB 4.0 matches for allorf_2069703_2069807

100.0%
NZ_CP061033.1:
Lanthipeptides: allorf_2069703_2069807_lanthipeptide
1
H A H Q D G G V A C C S C V L T R
17
H A H Q D G G V A C C S C V L T R
1
H A H Q D G G V A C C S C V L T R
17

#### MIBiG 4.0 matches for allorf_2069703_2069807

23.5%
BGC0001155.5 (AGY49587.1):
Thiopeptide: GE2270
10
C C S C
13
C C S C
9
C C S C
12
18.2%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
9
A C C S C V
14
A C C V
1
A T C E C V
6
allorf_2072629_2072850
Leader:
MCCLCSLPGSVSRLDQLWCHNLASLFWG
Core:
R D I F C Q N A G F Y E T N Q A A L R I L I N L H R H G P G L S H L L T R S K T W E A S A
Core with dehydrations:
R D I F Cys Q N A G F Y E Dhb N Q A A L R I L I N L H R H G P G L Dha H L L Dhb R Dha K Dhb W E A Dha A

#### antiSMASH-DB 4.0 matches for allorf_2072629_2072850

100.0%
NZ_CP061033.1:
Lanthipeptides: allorf_2072629_2072850_lanthipeptide
1
R D I F C Q N A G F Y E T N Q A A L R I L I N L H R H G P G L S H L L T R S K T W E A S A
45
R D I F C Q N A G F Y E T N Q A A L R I L I N L H R H G P G L S H L L T R S K T W E A S A
1
R D I F C Q N A G F Y E T N Q A A L R I L I N L H R H G P G L S H L L T R S K T W E A S A
45
17.8%
NC_012489.1:
Lanthipeptides: allorf_4588962_4589087_lanthipeptide
4
F C Q N A G F Y E T N Q A A L R
19
F C G E Q A L R
4
F C I G C G C V E G T Q R A L R
19
15.6%
NZ_CM000731.1 and 2 others:
NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptide NZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide
Lanthipeptides: BCERE0020_RS28875_lanthipeptide
28
G P G L S H L L T R S K T W E A S A
45
G P G L T+ W+ A
2
G P G W V E T L T K D C P W K Q P A
19
with 1 more sequence matches
13.3%
NZ_CP036053.1 and 8 others:
NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptide NZ_KB976276.1 Lanthipeptides: IIC_RS09105_lanthipeptide NZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptide NZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptide NZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptide NZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptide NZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptide NZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide
Lanthipeptides: EXW64_RS27135_lanthipeptide
28
G P G L S H L L T R S K T W E
42
G P G L T+ W+
2
G P G W V E T L T K D C P W K
16
allorf_2073279_2073341
Leader:
MADITYA
Core:
R T R Q G I R I R R F C H
Core with dehydrations:
R Dhb R Q G I R I R R F Cys H

#### antiSMASH-DB 4.0 matches for allorf_2073279_2073341

100.0%
NZ_CP061033.1:
Lanthipeptides: allorf_2073279_2073341_lanthipeptide
1
R T R Q G I R I R R F C H
13
R T R Q G I R I R R F C H
1
R T R Q G I R I R R F C H
13
19.4%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: allorf_0444250_0444393_lanthipeptide
Lanthipeptides: allorf_0444250_0444393_lanthipeptide
1
R T R Q G I R I R R F C H
13
R T++G I R+ C+
18
R T K E G I R L L E E C N
30
19.0%
NZ_VANP01000002.1:
Lanthipeptides: allorf_010170_010304_lanthipeptide
5
G I R I R R F C H
13
G+R++R+C
1
G V R V K R W C K
9
with 1 more sequence matches
10.3%
NZ_CP017169.1:
Lanthipeptides: allorf_8034042_8034278_lanthipeptide
5
G I R I R R F C H
13
G I R R R+ H
42
G I R S R R Y L H
50
allorf_2074137_2074262
Leader:
MATGTADIAQPALWGAALGGAAGSAAG
Core:
A A A S A F W W G V G S P C
Core with dehydrations:
A A A Dha A F W W G V G Dha P Cys

#### antiSMASH-DB 4.0 matches for allorf_2074137_2074262

100.0%
NZ_CP061033.1:
Lanthipeptides: allorf_2074137_2074262_lanthipeptide
1
A A A S A F W W G V G S P C
14
A A A S A F W W G V G S P C
1
A A A S A F W W G V G S P C
14
allorf_2076238_2076354
Leader:
MVRFIPCQRPSSSCLPYLLVGVVCDHRHASWGA
Core:
T I T T C
Core with dehydrations:
Dhb I Dhb Dhb Cys
allorf_2076770_2076883
Leader:
MLPGEGDLQHQGNGTAFGS
Core:
V P I W V L Q V G C R T S S Q A R R
Core with dehydrations:
V P I W V L Q V G Cys R Dhb Dha Dha Q A R R

#### antiSMASH-DB 4.0 matches for allorf_2076770_2076883

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: allorf_2076770_2076883_lanthipeptide
Lanthipeptides: allorf_2076770_2076883_lanthipeptide
1
V P I W V L Q V G C R T S S Q A R R
18
V P I W V L Q V G C R T S S Q A R R
1
V P I W V L Q V G C R T S S Q A R R
18
13.2%
NZ_CP011130.1 and 2 others:
NZ_CP023465.1 Lanthipeptides: allorf_4124021_4124236_lanthipeptide NZ_KQ061217.1 Lanthipeptides: allorf_2970820_2971035_lanthipeptide
Lanthipeptides: allorf_4082202_4082426_lanthipeptide
9
G C R T S S Q A R R
18
G C R T +A R R
33
G C R T Y G R A R R
42
allorf_2077498_2077734
Leader:
MLCLRRTARLHQRISEVHCQQDLTQPIPLIMFRSEITTEHFS
Core:
N H Q W G C T S H T R S L D V R S P Y S V P P K R I V L D Y Y V P I S K
Core with dehydrations:
N H Q W G Cys Dhb Dha H Dhb R Dha L D V R Dha P Y Dha V P P K R I V L D Y Y V P I Dha K

#### antiSMASH-DB 4.0 matches for allorf_2077498_2077734

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: allorf_2077498_2077734_lanthipeptide
Lanthipeptides: allorf_2077498_2077734_lanthipeptide
1
N H Q W G C T S H T R S L D V R S P Y S V P P K R I V L D Y Y V P I S K
36
N H Q W G C T S H T R S L D V R S P Y S V P P K R I V L D Y Y V P I S K
1
N H Q W G C T S H T R S L D V R S P Y S V P P K R I V L D Y Y V P I S K
36
25.0%
NZ_CP041604.2 and 2 others:
NZ_CP041610.2 Lanthipeptides: allorf_00762942_00763082_lanthipeptide NZ_CP041650.2 Lanthipeptides: allorf_01115746_01115886_lanthipeptide
Lanthipeptides: allorf_01200681_01200821_lanthipeptide
7
T S H T R S L D V R S P Y S V P P K R
25
T H +L R S P P P R
3
T G H E G A L A R R S P G P A P P A R
21
19.4%
NZ_JANYMP010000042.1:
Lanthipeptides: allorf_39377_39523_lanthipeptide
4
W G C T S H T R S L D V R S P Y S V P P K R
25
W G C H R + P R
8
W G C Y P H A H D G R G R E D S D I A P T R
29
allorf_2077699_2077851
Leader:
MVEPRCAAEAEHGCKKWLMAPLGA
Core:
R P V S R V L G S A L L S G L R P L T W C I C I P W
Core with dehydrations:
R P V Dha R V L G Dha A L L Dha G L R P L Dhb W Cys I Cys I P W

#### antiSMASH-DB 4.0 matches for allorf_2077699_2077851

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: allorf_2077699_2077851_lanthipeptide
Lanthipeptides: allorf_2077699_2077851_lanthipeptide
1
R P V S R V L G S A L L S G L R P L T W C I C I P W
26
R P V S R V L G S A L L S G L R P L T W C I C I P W
1
R P V S R V L G S A L L S G L R P L T W C I C I P W
26
23.1%
NZ_CP040916.1:
Lassopeptides: FH965_RS40555_lassopeptide
4
S R V L G S A L L S G L R P L T W C I
22
L G S G P W +
1
G E A L G S Y Y E G G F P P Y E W Y L
19
21.4%
NZ_CP012673.1:
Lanthipeptides: SOCE26_RS57340_lanthipeptide
8
G S A L L S G L R P L T W C I C
23
S A+ +P +W C C
3
A S A M A K I T Q P A S W C T C
18
with 1 more sequence matches
14.7%
NZ_FQZK01000006.1 and 1 other:
NZ_FQZK01000006.1 Lanthipeptides: allorf_210720_210950_lanthipeptide
Lanthipeptides: allorf_210720_210950_lanthipeptide
2
P V S R V L G S A L L S G L R P L T W C I C
23
P S +L S A+L G R P +C
35
P G S V I L F S A V L R G S R P T V R S V C
56
allorf_2092025_2092189
Leader:
MGSAEIGS
Core:
A S A V L L T T G S A R A G C P R A G L V M T S S V V T G S I V I D M V S F L S V C V V D M
Core with dehydrations:
A Dha A V L L Dhb Dhb G Dha A R A G Cys P R A G L V M Dhb Dha Dha V V Dhb G Dha I V I D M V Dha F L Dha V Cys V V D M

#### antiSMASH-DB 4.0 matches for allorf_2092025_2092189

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: allorf_2092025_2092189_lanthipeptide
Lanthipeptides: allorf_2092025_2092189_lanthipeptide
1
A S A V L L T T G S A R A G C P R A G L V M T S S V V T G S I V I D M V S F L S V C V V D M
46
A S A V L L T T G S A R A G C P R A G L V M T S S V V T G S I V I D M V S F L S V C V V D M
1
A S A V L L T T G S A R A G C P R A G L V M T S S V V T G S I V I D M V S F L S V C V V D M
46
21.7%
NZ_CP013141.1:
Lanthipeptides: allorf_5320245_5320430_lanthipeptide
1
A S A V L L T T G S A R A G C P
16
A A+ T G S A R A G P
10
A H A I T A T G G S A R A G W P
25
19.6%
NC_014483.2 and 17 others:
NC_014622.2 Lanthipeptides: PPSC2_RS36205_lanthipeptide NC_017542.1 Lanthipeptides: PPM_RS07465_lanthipeptide NZ_CP006872.1 Lanthipeptides: PPSQR21_RS07740_lanthipeptide NZ_CP023711.1 Lanthipeptides: CPY53_RS22235_lanthipeptide NZ_CP025957.1 Lanthipeptides: C1A50_RS07530_lanthipeptide NZ_CP029370.1 Lanthipeptides: DI243_RS07495_lanthipeptide NZ_CP040829.1 Lanthipeptides: FGY93_RS00500_lanthipeptide NZ_CP049598.1 Lanthipeptides: G7L40_RS00115_lanthipeptide NZ_CP073682.1 Lanthipeptides: KAI36_RS07745_lanthipeptide NZ_CP084033.1 Lanthipeptides: LAZ93_RS07550_lanthipeptide NZ_CP085682.1 Lanthipeptides: LJR53_RS07370_lanthipeptide NZ_CP086373.1 Lanthipeptides: LMH85_RS07780_lanthipeptide NZ_CP092779.1 Lanthipeptides: MJ749_RS07440_lanthipeptide NZ_CP097766.1 Lanthipeptides: MF620_RS07485_lanthipeptide NZ_CP102865.1 Lanthipeptides: NWS42_RS21195_lanthipeptide NZ_JWJJ01000002.1 Lanthipeptides: U707_RS10390_lanthipeptide NZ_POVT01000009.1 Lanthipeptides: C1T20_RS05900_lanthipeptide
Lanthipeptides: PPE_RS07020_lanthipeptide
18
A G L V M T S S V V T G S I V I D M-V S F L S V C
42
+G L+ T S T G++ + +S F C
1
S G L I C T P S C A T G T L N C Q V S L S F C K T C
26
with 3 more sequence matches
19.6%
NZ_JAIFIS010000001.1:
Lanthipeptides: K1X09_RS26315_lanthipeptide
18
A G L V M T S S V V T G S I V I D M-V S F L S V C
42
+G L+ T S +T G++ + +S F C
1
S G L I C T P S C L T G T L N C K I S L S F C R T C
26
17.4%
NZ_JALGRO010000002.1 and 1 other:
NZ_SNVW01000005.1 Lanthipeptides: EDF64_RS09155_lanthipeptide
Lanthipeptides: MT346_RS01980_lanthipeptide
14
G C P R A G L V M T S S V V T G S I V I D M V S
37
G C P G ++ T G I S
10
G C P T G G F A C F T A A C T G G C T I S S S S
33
15.2%
NZ_CP066203.1:
Lassopeptides: MacB4_RS04185_lassopeptide
17
R A G L V M T S S V V T G S I V
32
+G+++T +++T G S I V
1
N S G V L L T D T L L T G S I V
16

#### Lanthipeptide(s) for IAU67_RS09350

IAU67_RS09320
Leader:
MVKNAGIFEEISDQYVPEANAAGQGWGTLVTSLNCYGA
Core:
S W A L G N E G N F C T G T I E C Q K T C Q
Core with dehydrations:
Dha W A L G N E G N F Cys Dhb G Dhb I E Cys Q K Dhb Cys Q

#### antiSMASH-DB 4.0 matches for IAU67_RS09320

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: IAU67_RS09320_lanthipeptide
Lanthipeptides: IAU67_RS09320_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S W A L G N E G N F C T G T I E C Q K T C Q
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
50.0%
NZ_CKMQ01000043.1 and 10 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide
Lanthipeptides: AE832_RS11585_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S A L G N+G C T G T I E C Q C+
9
S E A L G N K G A V C T G T I E C Q N N C R
30
50.0%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS17475_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S L G N+G F C T T+E C +C
3
S S L L G N D G K F C T L T V E C M P S C N
24
with 103 more sequence matches
Only the first 10 are displayed here.
47.8%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide
Lanthipeptides: HBA49_RS00770_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S L G N G +C T T E C +C
2
S R L L G N N G R W C T I T K E C M P S C N
23
47.1%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide
Lanthipeptides: IE257_RS28650_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S W A L G N G+ C T T+E C Q K C Q
12
S W A L G N N G H L C T V T V E C Q K N C Q
33
46.4%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C
21
S A L G N G++C T T E C Q C
7
S A A L G N R G S Y C T L T K E C Q A C C
27
45.2%
NZ_GG657754.1 and 1 other:
NZ_GG657754.1 Lanthipeptides: SSOG_RS49055_lanthipeptide
Lanthipeptides: SSOG_RS49055_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C
21
S+ +G N G N F C T T+E C Q K C
10
S F V M G N L G N F C T A T L E C Q K N C
30
44.4%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C
21
S L G N G C T T E C Q+ C
6
S R K L G N T G Y V C T L T K E C Q R M C
26
43.2%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C Q
22
S W A L G N+G N F C T T+E C Q C+
16
S W A L G N D G N F C T A T V E C Q S N C K
37
42.9%
NZ_KE384107.1:
Lanthipeptides: G586_RS23925_lanthipeptide
1
S W A L G N E G N F C T G T I E C Q K T C
21
S +L G N G++C T T E C Q C
7
S A S L G N R G S Y C T I T K E C Q A C C
27
42.9%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
3
A L G N E G N F C T G T I E C Q K T C Q
22
+L G N+G C T T E C Q K C+
9
S L G N K G Y V C T L T K E C Q K L C R
28
42.3%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
4
L G N E G N F C T G T I E C Q K T C
21
L G N+G C T T E C Q C
8
L G N K G R I C T L T K E C Q S M C
25
41.4%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
4
L G N E G N F C T G T I E C Q K T C
21
L G N G F C T T E C Q +C
10
L G N T G Q F C T L T K E C Q P S C
27

#### MIBiG 4.0 matches for IAU67_RS09320

40.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
3
A L G N E G N F C T G T I E C Q K T C Q
22
A L G N G +C T T E C Q C
11
A L G N N G G W C T L T K E C Q P N C N
30
35.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
4
L G N E G N F C T G T I E C Q K T C Q
22
L G N+G +C T T+E C +C
10
L G N K G A Y C T L T V E C M P S C N
28
18.9%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
3
A L G N E G N F C T G T I E C Q K T C
21
A+G F C T +C C
20
A V G V S A A F C P-T T K C T S R C
37
with 1 more sequence matches
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
11
C T G T I E C Q K T C
21
C T + E C Q C
28
C T L S K E C Q P N C
38
IAU67_RS09325
Leader:
MHNYSASNGFISDEAMLQIIDANDASLSNQVAAGTTSPLCVVGGAVSAAS
Core:
A Y L D D A C P T S G C T H S C
Core with dehydrations:
A Y L D D A Cys P Dhb Dha G Cys Dhb H Dha Cys

#### antiSMASH-DB 4.0 matches for IAU67_RS09325

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: IAU67_RS09325_lanthipeptide
Lanthipeptides: IAU67_RS09325_lanthipeptide
1
A Y L D D A C P T S G C T H S C
16
A Y L D D A C P T S G C T H S C
1
A Y L D D A C P T S G C T H S C
16
50.0%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28640_lanthipeptide
Lanthipeptides: IE257_RS28640_lanthipeptide
7
C P T S G C T H S C
16
C P T S G C T C
1
C P T S G C T G R C
10
50.0%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17825_lanthipeptide
Lanthipeptides: KPP03845_RS17825_lanthipeptide
7
C P T S G C T H S C
16
C P T S G C T C
1
C P T S G C T K R C
10
with 67 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_GG657754.1 and 1 other:
NZ_GG657754.1 Lanthipeptides: SSOG_RS27835_lanthipeptide
Lanthipeptides: SSOG_RS27835_lanthipeptide
7
C P T S G C T H S C
16
C P T S G C T C
1
C P T S G C T S K C
10
47.1%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide
Lanthipeptides: DEI99_RS08060_lanthipeptide
1
A Y L D D A C P T S G C T H S C
16
A L C P T C T C
2
A A L P G F C P T G A C T S K C
17
43.8%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS31015_lanthipeptide
Lanthipeptides: CN325_RS31015_lanthipeptide
7
C P T S G C T H S C
16
C P T S C T C
3
C P T S K C T T R C
12
37.5%
NZ_BJTV01000004.1 and 5 others:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35800_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide
Lanthipeptides: TNCT1_RS35800_lanthipeptide
7
C P T S G C T H S C
16
C P T+ C T +C
4
C P T T K C T S A C
13
37.5%
NZ_JAGGRJ010000019.1:
Lanthipeptides: allorf_047072_047179_lanthipeptide
4
D D A C P T S G C
12
D D A P G C
2
D D A Q P V P G C
10
30.8%
NZ_JALAPU010000003.1 and 7 others:
NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide
Lanthipeptides: MOD17_RS07925_lanthipeptide
1
A Y L D-D A C P T S G C T H S C
16
A Y+ + C P T+ C T +C
10
A Y I S S N T C P T T A C T R A C
26
29.6%
NZ_KE384533.1 and 2 others:
NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide
Lanthipeptides: K329_RS31315_lanthipeptide
1
A Y L D-D A C P T S G C T H S C
16
A Y+ + C P T+ C T C
11
A Y V S T N T C P T T S C T D E C
27
28.6%
NZ_CP115450.1 and 1 other:
NZ_CP115450.1 Lanthipeptides: O1G21_RS35405_lanthipeptide
Lanthipeptides: O1G21_RS35405_lanthipeptide
7
C P T S G C T H S C
16
C P T+ C T C
12
C P T T A C T S R C
21
28.6%
NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide
Lanthipeptides: BUE45_RS13105_lanthipeptide
1
A Y L D D A C P T S G C T H S C
16
A D C P T+ C T C
13
A A W G D G C P T T V C T S R C
28
28.1%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
1
A Y L-D D A C P T S G C T H S C
16
A Y+ D C P T+ C T +C
16
A Y V S D K T C P T T A C T R A C
32

#### MIBiG 4.0 matches for IAU67_RS09325

23.1%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
7
C P T S G C T H S C
16
C P T+ C T C
17
C P T T K C T S K C
26
16.2%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
7
C P T S G C T H S C
16
C P T+ C T C
28
C P T T K C T S R C
37
IAU67_RS09375
Leader:
MWARALKACRDHIDDEGGMSTIEYA
Core:
L G C V A A A A L G A L L Y T V V T S G A V E D A L R G I F E R A L N E G G K
Core with dehydrations:
L G Cys V A A A A L G A L L Y Dhb V V Dhb Dha G A V E D A L R G I F E R A L N E G G K

#### antiSMASH-DB 4.0 matches for IAU67_RS09375

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: IAU67_RS09375_lanthipeptide
Lanthipeptides: IAU67_RS09375_lanthipeptide
1
L G C V A A A A L G A L L Y T V V T S G A V E D A L R G I F E R A L N E G G K
39
L G C V A A A A L G A L L Y T V V T S G A V E D A L R G I F E R A L N E G G K
1
L G C V A A A A L G A L L Y T V V T S G A V E D A L R G I F E R A L N E G G K
39
23.1%
NZ_CP033932.1 and 1 other:
NZ_CP084347.1 Lanthipeptides: KB553_RS11820_lanthipeptide
Lanthipeptides: EG339_RS01270_lanthipeptide
2
G C V A A A A L G A L L Y T V V T S G A V E D A L R
27
G C A A G + T+ A E D +
11
G C D A T A V C G C V T Q T I K K P K A F E D G I E
36
allorf_2076238_2076354
Leader:
MVRFIPCQRPSSSCLPYLLVGVVCDHRHASWGA
Core:
T I T T C
Core with dehydrations:
Dhb I Dhb Dhb Cys
allorf_2076770_2076883
Leader:
MLPGEGDLQHQGNGTAFGS
Core:
V P I W V L Q V G C R T S S Q A R R
Core with dehydrations:
V P I W V L Q V G Cys R Dhb Dha Dha Q A R R

#### antiSMASH-DB 4.0 matches for allorf_2076770_2076883

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: allorf_2076770_2076883_lanthipeptide
Lanthipeptides: allorf_2076770_2076883_lanthipeptide
1
V P I W V L Q V G C R T S S Q A R R
18
V P I W V L Q V G C R T S S Q A R R
1
V P I W V L Q V G C R T S S Q A R R
18
13.2%
NZ_CP011130.1 and 2 others:
NZ_CP023465.1 Lanthipeptides: allorf_4124021_4124236_lanthipeptide NZ_KQ061217.1 Lanthipeptides: allorf_2970820_2971035_lanthipeptide
Lanthipeptides: allorf_4082202_4082426_lanthipeptide
9
G C R T S S Q A R R
18
G C R T +A R R
33
G C R T Y G R A R R
42
allorf_2077498_2077734
Leader:
MLCLRRTARLHQRISEVHCQQDLTQPIPLIMFRSEITTEHFS
Core:
N H Q W G C T S H T R S L D V R S P Y S V P P K R I V L D Y Y V P I S K
Core with dehydrations:
N H Q W G Cys Dhb Dha H Dhb R Dha L D V R Dha P Y Dha V P P K R I V L D Y Y V P I Dha K

#### antiSMASH-DB 4.0 matches for allorf_2077498_2077734

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: allorf_2077498_2077734_lanthipeptide
Lanthipeptides: allorf_2077498_2077734_lanthipeptide
1
N H Q W G C T S H T R S L D V R S P Y S V P P K R I V L D Y Y V P I S K
36
N H Q W G C T S H T R S L D V R S P Y S V P P K R I V L D Y Y V P I S K
1
N H Q W G C T S H T R S L D V R S P Y S V P P K R I V L D Y Y V P I S K
36
25.0%
NZ_CP041604.2 and 2 others:
NZ_CP041610.2 Lanthipeptides: allorf_00762942_00763082_lanthipeptide NZ_CP041650.2 Lanthipeptides: allorf_01115746_01115886_lanthipeptide
Lanthipeptides: allorf_01200681_01200821_lanthipeptide
7
T S H T R S L D V R S P Y S V P P K R
25
T H +L R S P P P R
3
T G H E G A L A R R S P G P A P P A R
21
19.4%
NZ_JANYMP010000042.1:
Lanthipeptides: allorf_39377_39523_lanthipeptide
4
W G C T S H T R S L D V R S P Y S V P P K R
25
W G C H R + P R
8
W G C Y P H A H D G R G R E D S D I A P T R
29
allorf_2077699_2077851
Leader:
MVEPRCAAEAEHGCKKWLMAPLGA
Core:
R P V S R V L G S A L L S G L R P L T W C I C I P W
Core with dehydrations:
R P V Dha R V L G Dha A L L Dha G L R P L Dhb W Cys I Cys I P W

#### antiSMASH-DB 4.0 matches for allorf_2077699_2077851

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: allorf_2077699_2077851_lanthipeptide
Lanthipeptides: allorf_2077699_2077851_lanthipeptide
1
R P V S R V L G S A L L S G L R P L T W C I C I P W
26
R P V S R V L G S A L L S G L R P L T W C I C I P W
1
R P V S R V L G S A L L S G L R P L T W C I C I P W
26
23.1%
NZ_CP040916.1:
Lassopeptides: FH965_RS40555_lassopeptide
4
S R V L G S A L L S G L R P L T W C I
22
L G S G P W +
1
G E A L G S Y Y E G G F P P Y E W Y L
19
21.4%
NZ_CP012673.1:
Lanthipeptides: SOCE26_RS57340_lanthipeptide
8
G S A L L S G L R P L T W C I C
23
S A+ +P +W C C
3
A S A M A K I T Q P A S W C T C
18
with 1 more sequence matches
14.7%
NZ_FQZK01000006.1 and 1 other:
NZ_FQZK01000006.1 Lanthipeptides: allorf_210720_210950_lanthipeptide
Lanthipeptides: allorf_210720_210950_lanthipeptide
2
P V S R V L G S A L L S G L R P L T W C I C
23
P S +L S A+L G R P +C
35
P G S V I L F S A V L R G S R P T V R S V C
56
allorf_2092025_2092189
Leader:
MGSAEIGS
Core:
A S A V L L T T G S A R A G C P R A G L V M T S S V V T G S I V I D M V S F L S V C V V D M
Core with dehydrations:
A Dha A V L L Dhb Dhb G Dha A R A G Cys P R A G L V M Dhb Dha Dha V V Dhb G Dha I V I D M V Dha F L Dha V Cys V V D M

#### antiSMASH-DB 4.0 matches for allorf_2092025_2092189

100.0%
NZ_CP061033.1 and 1 other:
NZ_CP061033.1 Lanthipeptides: allorf_2092025_2092189_lanthipeptide
Lanthipeptides: allorf_2092025_2092189_lanthipeptide
1
A S A V L L T T G S A R A G C P R A G L V M T S S V V T G S I V I D M V S F L S V C V V D M
46
A S A V L L T T G S A R A G C P R A G L V M T S S V V T G S I V I D M V S F L S V C V V D M
1
A S A V L L T T G S A R A G C P R A G L V M T S S V V T G S I V I D M V S F L S V C V V D M
46
21.7%
NZ_CP013141.1:
Lanthipeptides: allorf_5320245_5320430_lanthipeptide
1
A S A V L L T T G S A R A G C P
16
A A+ T G S A R A G P
10
A H A I T A T G G S A R A G W P
25
19.6%
NC_014483.2 and 17 others:
NC_014622.2 Lanthipeptides: PPSC2_RS36205_lanthipeptide NC_017542.1 Lanthipeptides: PPM_RS07465_lanthipeptide NZ_CP006872.1 Lanthipeptides: PPSQR21_RS07740_lanthipeptide NZ_CP023711.1 Lanthipeptides: CPY53_RS22235_lanthipeptide NZ_CP025957.1 Lanthipeptides: C1A50_RS07530_lanthipeptide NZ_CP029370.1 Lanthipeptides: DI243_RS07495_lanthipeptide NZ_CP040829.1 Lanthipeptides: FGY93_RS00500_lanthipeptide NZ_CP049598.1 Lanthipeptides: G7L40_RS00115_lanthipeptide NZ_CP073682.1 Lanthipeptides: KAI36_RS07745_lanthipeptide NZ_CP084033.1 Lanthipeptides: LAZ93_RS07550_lanthipeptide NZ_CP085682.1 Lanthipeptides: LJR53_RS07370_lanthipeptide NZ_CP086373.1 Lanthipeptides: LMH85_RS07780_lanthipeptide NZ_CP092779.1 Lanthipeptides: MJ749_RS07440_lanthipeptide NZ_CP097766.1 Lanthipeptides: MF620_RS07485_lanthipeptide NZ_CP102865.1 Lanthipeptides: NWS42_RS21195_lanthipeptide NZ_JWJJ01000002.1 Lanthipeptides: U707_RS10390_lanthipeptide NZ_POVT01000009.1 Lanthipeptides: C1T20_RS05900_lanthipeptide
Lanthipeptides: PPE_RS07020_lanthipeptide
18
A G L V M T S S V V T G S I V I D M-V S F L S V C
42
+G L+ T S T G++ + +S F C
1
S G L I C T P S C A T G T L N C Q V S L S F C K T C
26
with 3 more sequence matches
19.6%
NZ_JAIFIS010000001.1:
Lanthipeptides: K1X09_RS26315_lanthipeptide
18
A G L V M T S S V V T G S I V I D M-V S F L S V C
42
+G L+ T S +T G++ + +S F C
1
S G L I C T P S C L T G T L N C K I S L S F C R T C
26
17.4%
NZ_JALGRO010000002.1 and 1 other:
NZ_SNVW01000005.1 Lanthipeptides: EDF64_RS09155_lanthipeptide
Lanthipeptides: MT346_RS01980_lanthipeptide
14
G C P R A G L V M T S S V V T G S I V I D M V S
37
G C P G ++ T G I S
10
G C P T G G F A C F T A A C T G G C T I S S S S
33
15.2%
NZ_CP066203.1:
Lassopeptides: MacB4_RS04185_lassopeptide
17
R A G L V M T S S V V T G S I V
32
+G+++T +++T G S I V
1
N S G V L L T D T L L T G S I V
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.50 out of 20.47
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.00 out of 29.72
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.73 out of 23.79
Confidence: medium
Additional weak hits (6):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.45 out of 29.38
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.19 out of 26.85
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.41 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.21 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.22 out of 31.73
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.92 out of 25.75
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

IAU67_RS09320 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 2317.0 Da
  Molecular weight: 2318.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2336.6 Da N = 1
IAU67_RS09325 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 1570.6 Da
  Molecular weight: 1571.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1589.7 Da N = 1
IAU67_RS09375 - Class II
  Cleavage pHMM score: -1.50
  RODEO score: 0
  Monoisotopic mass: 3821.1 Da
  Molecular weight: 3823.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3841.4 Da N = 1
    3859.4 Da N = 2
allorf_2076238_2076354 - Class II
  Cleavage pHMM score: -4.10
  RODEO score: 0
  Monoisotopic mass: 483.2 Da
  Molecular weight: 483.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    501.6 Da N = 1
    519.6 Da N = 2
allorf_2076770_2076883 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 2001.1 Da
  Molecular weight: 2002.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2020.4 Da N = 1
    2038.4 Da N = 2
allorf_2077498_2077734 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 4072.2 Da
  Molecular weight: 4074.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4092.6 Da N = 1
    4110.6 Da N = 2
    4128.7 Da N = 3
    4146.7 Da N = 4
    4164.7 Da N = 5
    4182.7 Da N = 6
allorf_2077699_2077851 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 2820.6 Da
  Molecular weight: 2822.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2840.4 Da N = 1
    2858.5 Da N = 2
allorf_2092025_2092189 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 4372.3 Da
  Molecular weight: 4375.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4393.2 Da N = 1
    4411.2 Da N = 2
    4429.2 Da N = 3
    4447.3 Da N = 4
    4465.3 Da N = 5
    4483.3 Da N = 6
    4501.3 Da N = 7
    4519.3 Da N = 8
    4537.4 Da N = 9
IAU67_RS10055 - Class II
  Cleavage pHMM score: -5.50
  RODEO score: 0
  Monoisotopic mass: 6655.8 Da
  Molecular weight: 6659.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6677.9 Da N = 1
    6695.9 Da N = 2
    6713.9 Da N = 3
    6731.9 Da N = 4
    6750.0 Da N = 5
    6768.0 Da N = 6
IAU67_RS09320 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 2317.0 Da
  Molecular weight: 2318.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2336.6 Da N = 1
IAU67_RS09325 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 1570.6 Da
  Molecular weight: 1571.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1589.7 Da N = 1
IAU67_RS09375 - Class II
  Cleavage pHMM score: -1.50
  RODEO score: 0
  Monoisotopic mass: 3821.1 Da
  Molecular weight: 3823.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3841.4 Da N = 1
    3859.4 Da N = 2
allorf_2069703_2069807 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 1719.8 Da
  Molecular weight: 1720.9 Da
  Number of bridges: 2
allorf_2072629_2072850 - Class II
  Cleavage pHMM score: -5.30
  RODEO score: 0
  Monoisotopic mass: 4996.6 Da
  Molecular weight: 4999.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5017.6 Da N = 1
    5035.6 Da N = 2
    5053.7 Da N = 3
    5071.7 Da N = 4
    5089.7 Da N = 5
allorf_2073279_2073341 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 1679.9 Da
  Molecular weight: 1681.0 Da
  Number of bridges: 1
allorf_2074137_2074262 - Class II
  Cleavage pHMM score: -4.90
  RODEO score: 0
  Monoisotopic mass: 1372.6 Da
  Molecular weight: 1373.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1391.5 Da N = 1
allorf_2076238_2076354 - Class II
  Cleavage pHMM score: -4.10
  RODEO score: 0
  Monoisotopic mass: 483.2 Da
  Molecular weight: 483.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    501.6 Da N = 1
    519.6 Da N = 2
allorf_2076770_2076883 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 2001.1 Da
  Molecular weight: 2002.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2020.4 Da N = 1
    2038.4 Da N = 2
allorf_2077498_2077734 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 4072.2 Da
  Molecular weight: 4074.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4092.6 Da N = 1
    4110.6 Da N = 2
    4128.7 Da N = 3
    4146.7 Da N = 4
    4164.7 Da N = 5
    4182.7 Da N = 6
allorf_2077699_2077851 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 2820.6 Da
  Molecular weight: 2822.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2840.4 Da N = 1
    2858.5 Da N = 2
allorf_2092025_2092189 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 4372.3 Da
  Molecular weight: 4375.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4393.2 Da N = 1
    4411.2 Da N = 2
    4429.2 Da N = 3
    4447.3 Da N = 4
    4465.3 Da N = 5
    4483.3 Da N = 6
    4501.3 Da N = 7
    4519.3 Da N = 8
    4537.4 Da N = 9

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism
NtrC | Nitrogen regulatory protein C
VqsM | Regulator of quorum-sensing signalling systems