LOCUS       NZ_CP060417            24458 bp    DNA     circular CON 22-JUN-2024
DEFINITION  Bacillus subtilis subsp. subtilis strain ONU 559 chromosome,
            complete genome.
ACCESSION   NZ_CP060417
VERSION     NZ_CP060417.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis subsp. subtilis
  ORGANISM  Bacillus subtilis subsp. subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4004302)
  AUTHORS   Ivanytsia,V., Vasylieva,N., Ostapchuk,A., Kalinowski,J.,
            Rueckert,C., Luzhetskyy,A., Rebets,Y. and Shtenikov,M.
  TITLE     Comparative genomic characteristics of Bacillus from anaerobic sea
            sediments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4004302)
  AUTHORS   Ostapchuk,A., Kalinowski,J., Rueckert,C., Luzhetskyy,A. and
            Rebets,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-AUG-2020) Microbiology, virology and biotechnology,
            Odessa National after I.I. Mechnikov, Dvoryanska, 2, Odessa 65082,
            Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 12.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014298115.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:49:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,114
            CDSs (total)                      :: 3,992
            Genes (coding)                    :: 3,914
            CDSs (with protein)               :: 3,914
            Genes (RNA)                       :: 122
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 53 of 78
            Pseudo Genes (incomplete)         :: 35 of 78
            Pseudo Genes (internal stop)      :: 13 of 78
            Pseudo Genes (multiple problems)  :: 19 of 78
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:10:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 204347
            Orig. end                         :: 228805
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP060417.1.
            Bacteria and source DNA available from Collection of the sea and
            useful microorganisms of Odessa I.I. Mechnikov National University.
            Address:  Ukraine, Odesa, Shampanskii lane 2/2.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24458
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24458
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24458
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14458](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14458
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            397..1914
                     /gene="mpsA"
                     /locus_tag="H8S71_RS01170"
                     /old_locus_tag="H8S71_01170"
     CDS             397..1914
                     /EC_number="1.6.5.9"
                     /codon_start=1
                     /gene="mpsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388064.1"
                     /locus_tag="H8S71_RS01170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01170"
                     /product="NADH dehydrogenase subunit 5"
                     /protein_id="WP_187002027.1"
                     /transl_table=11
                     /translation="MLVSLSLSSLLTLFFIMFMASGISGLLFLHPRVPLSFVRIHIGIL
                     ALPLLVSLLILANSGVSGNVGPWHLDSLACLMTFFVLAIGFIIQRFSVRYLMGDRSYRK
                     YFTLFTFTTGAASMTWLSGDLRLMVLFWGATLVGLTLLIRLNSAWQVASEAAKVSGRLF
                     LLSWFSLFFAMMWLFHATGQWQLSLVVTNESLAGLGEWERTGIQLLIVLAVIIPAAQWP
                     FQRWLVESIVAPTPVSAIMHAGLVNAGGIILTRFSPLFHGGIASIVLLLLAGISVLIGT
                     GISLVQVDYKRQLVGSTIGQMGFMLIQCALGAYIAAIIHLILHGLFKATLFLQAGSAVG
                     RHEVSARTNERTSYLWVMAGRILSLVIGVAFWLAAPGEGYQFISALILGWSLSVSWTQL
                     VAFGEGRIGRIAGLTVLGGAALVYFIIHNLFYKWLHTTIFQSVQPPMSAVMIVVCLLLF
                     GSALGTWVARHRSSIFFAVLYLWLVRLGEAKPKSVESHPDYLKQYIS"
     gene            1929..4544
                     /gene="mpsB"
                     /locus_tag="H8S71_RS01175"
                     /old_locus_tag="H8S71_01175"
     CDS             1929..4544
                     /codon_start=1
                     /gene="mpsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388065.2"
                     /locus_tag="H8S71_RS01175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01175"
                     /product="YbcC family protein"
                     /protein_id="WP_187002028.1"
                     /transl_table=11
                     /translation="MGITSVLTKDNVKKIDTDIDVQERDLNVFITSASRVIAPLWPIST
                     FAARNPWMGLENQPFDQVASWLKNTRDVDIYPSASMIRSAKNKGEIDEDFVEMGLQRWL
                     DSHSYHIPRDVAERFCHAALKLDPLPSDLLSSHELEKLVGECSGLDYIENVFMQPLSSY
                     IENQDGERLVNILDHHVIKWSKLYLDDSQAGWTMPNREEGFYRAWQHLIQYDPALSKKQ
                     RERVKDWPKEAHLALQKALFALEIPESEIQTYLEGHLLSLPGWAGMMLWRSQQSSHEHA
                     LLTEYLAVRISMEWALIKPYLPLTNERSKKTISIAPLIAAWIHWGGLTLEEWSQMTAIE
                     QNEYLSFAYSFDEKLRKKLWLEAWEQTYTDRLSQKIISKQRETGRKKSALAQLAFCIDV
                     RSEPFRRHLEKEGPFETIGIAGFFGVPIATCELGSKHSHASLPIIQKPQNKIKEFADED
                     VFKKYNQRKQAIHSLSHTFKTMKQNALSSLLLPELSGPWLTLQMAARSFVPRKAGRFIR
                     NLREAWLRKPDTKLSLHHDATEAEIPVGFTDEEKVNYARQALKMMGLTENIAPLVVICG
                     HGSQSTNNPYSAALDCGACGGAAGGFNARVLAALCNLSEVREVLLTEGIKIPEDTVFAA
                     AEHNTTVDELHWLYVPELSEAAQEAFEQIEAVMPKVRHHVNAERLAQLPNFQSKLKNPK
                     AEANRFAEDWSEIRPEWGLARNAAFIIGKRELTQDCDLEGRAFLHNYDWKQDESGELLA
                     NIIAGPGTVAQWINLQYYASTVAPHYYGSGNKATQTVTAGLGVMQGNASDLLAGLPWQS
                     VMESDHEAYHSPLRLLILIQAPREYVERLLNHDSAFLQKVQNGWVRLANIDPEGCWESW
                     "
     gene            4621..5148
                     /gene="ybcF"
                     /locus_tag="H8S71_RS01180"
                     /old_locus_tag="H8S71_01180"
     CDS             4621..5148
                     /codon_start=1
                     /gene="ybcF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388067.1"
                     /locus_tag="H8S71_RS01180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01180"
                     /product="carbonic anhydrase"
                     /protein_id="WP_169038009.1"
                     /transl_table=11
                     /translation="MNVNQNKKVLFLTDIENGLEPILQEATNTSAENMLTMQSYGASIS
                     HPYGEIMRSVIFAIYQEDVEEIFVVGTKDKKTSAGNGLTQLETMKDKIQTLDYLFQNCK
                     PEFFGGTVDEWLNENSSDTIEKSVDMIRHHPLVPSYVKVRGLFVNHNDGKPSIVEVPDV
                     KTGQAIPDHCLS"
     gene            5209..5499
                     /gene="ybcH"
                     /locus_tag="H8S71_RS01185"
                     /old_locus_tag="H8S71_01185"
     CDS             5209..5499
                     /codon_start=1
                     /gene="ybcH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388068.1"
                     /locus_tag="H8S71_RS01185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01185"
                     /product="DUF6407 family protein"
                     /protein_id="WP_015252954.1"
                     /transl_table=11
                     /translation="MSANLTDFVTKTIEDMNSFDRENMECMKKLIRKAIDFYHLKSYEE
                     VEETHSGNVRFLHVHSMMEENMLSKMIVVTRNGKTDLDIEGVYEGYVVREY"
     gene            5557..5931
                     /gene="ybcI"
                     /locus_tag="H8S71_RS01190"
                     /old_locus_tag="H8S71_01190"
     CDS             5557..5931
                     /codon_start=1
                     /gene="ybcI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388069.1"
                     /locus_tag="H8S71_RS01190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01190"
                     /product="DUF2294 domain-containing protein"
                     /protein_id="WP_003246482.1"
                     /transl_table=11
                     /translation="MKKSKGSIESEISKSITQWEKDYLGRGSVSVKTDILRDMIIVNLK
                     GILTPAEYVVCGSKEGMLSIKQTRSELVESGIEGLKDIILKITGEKVKSFHTDLSSRTG
                     ERVMVFKLCNDLEKNLEKIL"
     gene            6402..6704
                     /gene="ybzH"
                     /locus_tag="H8S71_RS01195"
                     /old_locus_tag="H8S71_01195"
     CDS             6402..6704
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="ybzH"
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097670.1"
                     /locus_tag="H8S71_RS01195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01195"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_003234907.1"
                     /transl_table=11
                     /translation="MEPIEVFKALSNESRLQILQWLKEPDRHFAPHEGIDMNTIGVCVS
                     QITDKLKMTQSTASQYLTILLRAGLIKAERIGKYTYYKRDEEAIGKLADFLKTEI"
     gene            6831..8003
                     /gene="ybcL"
                     /locus_tag="H8S71_RS01200"
                     /old_locus_tag="H8S71_01200"
     CDS             6831..8003
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybcL"
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388070.1"
                     /locus_tag="H8S71_RS01200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01200"
                     /product="MFS transporter"
                     /protein_id="WP_169038008.1"
                     /transl_table=11
                     /translation="MSNTWKIYILAIVSFLVGTSEYIISGILDQIAHTLGITLAAAGQL
                     ITIFSLVYALSTPVLMALTASMDRRKLMMYALGLFVFGNVLAFVLPGYGWFIAARIIMA
                     MGAGVVVVTALTIAAKIASEGKQGSAIATVVMGFTASLIIGVPLGRMIAVALGWKSVFG
                     AIALLGLIAMVVIFFTLPHTEGDKPVPLLQQLALFKKRKVAMGLSITFFWLGGYSVAYT
                     YLSPYLLNISGINGKLLSGVLLIFGIASLVGSKFGGYSTDKWGVSFTLVGGMTLHIVTL
                     ILLSLVTHSYIGVLVILILWSFAAWSTGPTQQFHLATIEPEMSGVLLSMNQSMMQFAMA
                     VGAGIGGVFVENVSLTSITWVGALGVMIAIIASLLIFNSQPKQALKDINQ"
     gene            <8102..8449
                     /locus_tag="H8S71_RS01205"
                     /old_locus_tag="H8S71_01205"
                     /pseudo=""
     CDS             <8102..8449
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388059.1"
                     /locus_tag="H8S71_RS01205"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="H8S71_01205"
                     /product="glutamine--fructose-6-phosphate aminotransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VCVEGALELKEIS"
     gene            8767..8937
                     /locus_tag="H8S71_RS01210"
     CDS             8767..8937
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Antimicr18"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="H8S71_RS01210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_015715148.1"
                     /sec_met_domain="Antimicr18 (E-value: 7.9e-06, bitscore:
                     23.8, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKNNIFDLDINKKMESTSEVSAQTWATIGKTIVQSVKKCRTFTC
                     GCSLGSCSNCN"
     CDS_motif       8767..8838
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKNNIFDLDINKKMESTSEVSAQ"
                     /locus_tag="H8S71_RS01210_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8839..8937
                     /prepeptide="core"
                     /locus_tag="H8S71_RS01210_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="14.10"
                     /molecular_weight="3235.8"
                     /monoisotopic_mass="3233.6"
                     /core_sequence="TWATIGKTIVQSVKKCRTFTCGCSLGSCSNCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKNNIFDLDINKKMESTSEVSAQ"
                     /leader_location="[8766:8838](+)"
                     /alternative_weights="3253.8"
                     /alternative_weights="3271.8"
                     /alternative_weights="3289.8"
                     /alternative_weights="3307.8"
     gene            9026..10000
                     /locus_tag="H8S71_RS01215"
                     /old_locus_tag="H8S71_01210"
     CDS             9026..10000
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="H8S71_RS01215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01210"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_169038007.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.4e-25, bitscore:
                     88.1, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNMTTNALPNQFSWNSYKVTNGYRLYDLQVGSPLIKIAVIDSGYD
                     PNHSEITGNIDKKKSCSFVDYENFNEDLYGHGTAVISVIVGKNQVKGVAPGITIISYKV
                     LDRNGFGKIEWVIHAILKAIEDCVHIINLSHVFTMFGLGNKGAFNKLQQAINKARKKGI
                     IIVGAAGNQGVLLDMKSTSLYPTIKGINYVTSTNKNNYTSSYANIGSIIRFAAPSGELD
                     ETNNVTDLIIVAHPTNFPKTKFEKAIGLPDFYTVTCGTSISAAMFSSLIALVLTEYLIC
                     KQIHLSEKEILNIIQKNSSRVKDQNSIFEINAYSVIKFIKGLL"
     gene            10001..13111
                     /locus_tag="H8S71_RS01220"
                     /old_locus_tag="H8S71_01215"
     CDS             10001..13111
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="H8S71_RS01220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01215"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_169038006.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.5e-132,
                     bitscore: 439.6, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.6e-07,
                     bitscore: 29.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.4e-30, bitscore:
                     102.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKYLSSDLFMYRKPILDLSFYKECLAFDNEFNEEEYIAKISNL
                     LNTNPTIAEAIYFASEPLYNSFLNIEKLKKKKRKSVIDSMLKFLIRMSTRPTPFGLFSG
                     IGVETFSGQDESLTKDSEVIKNTRLDMCWIYFLIRKLESNLSILEQLTVENNSLVYNHG
                     DRIKLSYQSLLHSDDNDQSLEMLTLRKTAVMDYVYSQAEFGINYSTLRDSINKTYSVTD
                     DISNDFLNSLLKNEVIITNLRTSLVNSDPFENILNIISKMHNVEEELNYLVRLKKSIEE
                     YKKSSGELGISILKKIKKEMRVIGYEGDDFLRTDLYYVKNKKRYINNNQKDSIEKLAEI
                     LSLLGSVNSFQPLEAYRDEFIDKYGIFQEVPLLELIDEELGIGLPPEYHENRHKPSQPE
                     PSNEFHRIKNIISSWQAEVSLSKNHEIKLDDEKIKHLFNSEELNNIAVSQELELYFNIL
                     LDEHKENKLYLNPNCGSNSLFQTYGRFKYFLGESDKEYIKQFSHIEKDVIFAEVTYYPT
                     HGKTANIINAETCFDYEIAFSCNSSKDNKHSIALSDLYVGSTYNFIYLKSKKLDKIIIP
                     KLSHMFNYSMGPKIYRFLVDIGVQYQKQWSNIDSFFYDAPIKPRVIYNNIVLSPKKWNL
                     NKSIIPFECDSREKFHYYIKDWKKRYKVPDFIYLIEFDNKLLLNLENISHIKIIYNEFK
                     KLSNNQSLQFLEAEKELFNSHNNEIEEYVFTLKSKLHQLELDSYMTNIQSEMPFKYTSD
                     NERLKFLGTEWIYVKLYGLGTRENEFIADELGSFIKKHLDIGTIKSSFFIRYSDPKQHL
                     RVRFKVEKNNIFDTVLPIIIKWLEEMRAKGFVNYYCFDPYNPEIERYGGEQSHKIAEDL
                     FFCDSLIVSEWIQINRSGNVNIDEVTFGVFNILQLLKLFDLNIEEQMTWLEINTKPQKY
                     ANEFRGKKSTLIELADLIYTNKKLDKYNKISSIIEIREKAAITYSKSIENNPDFLIKNI
                     IMSVIHMHCNRLYGINRDKENLVIGLAYHTIKNYNNALKYNNVLIPN"
     aSDomain        10457..10732
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_H8S71_RS01220_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.10E-09"
                     /identifier="RREFam001.1"
                     /label="H8S71_RS01220"
                     /locus_tag="H8S71_RS01220"
                     /protein_end="244"
                     /protein_start="152"
                     /score="29.8"
                     /tool="antismash"
                     /translation="VENNSLVYNHGDRIKLSYQSLLHSDDNDQSLEMLTLRKTAVMDYV
                     YSQAEFGINYSTLRDSINKTYSVTDDISNDFLNSLLKNEVIITNLRT"
     gene            13136..14458
                     /locus_tag="H8S71_RS01225"
                     /old_locus_tag="H8S71_01220"
     CDS             13136..14458
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="H8S71_RS01225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01220"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_169038005.1"
                     /sec_met_domain="LANC_like (E-value: 1e-61, bitscore:
                     206.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKCKNQDFLTDILLDIANSIKDKSETEKIILGDRNNPEDIIEVV
                     SLAAGYPGICVFLGYMDKVFPEDGWDVVAHDYLTDLISLIQTNKTYSLSLFNGLAGVLV
                     ALETCSRGGTRYTKIINQVLTLILENYKHYLSEDLLKLKKEGVSASEYDVISGWTGVGR
                     TLLHFDQISNKGDISLKKALHDIAEYLLLVSSIDTLSNMPNWLISNENLPLDIEKKTYK
                     KGYFNSGMAHGISGVLAFLSILKKENYKIKNLELGIKNIQNWIFEKVKTHKGIYYIPNV
                     IENEVVRNEAFFNHRDAWCYGTPGVSRAIFLSGIALNDQRVKMKALELFKTFFLRDEKD
                     RKIISPTICHGYAGILMLTLRMYKDTNDRFLADKMHDILNEMLTFYSQLNFSKFNNYEL
                     ISGKIVEEKKVGLLEGSTGIALVLISFIFGQDSWDKIFLIS"
     gene            14471..15061
                     /locus_tag="H8S71_RS01230"
                     /old_locus_tag="H8S71_01225"
     CDS             14471..15061
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039548.3"
                     /locus_tag="H8S71_RS01230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01225"
                     /product="DUF5823 family protein"
                     /protein_id="WP_169038004.1"
                     /transl_table=11
                     /translation="MIQAVLEITIKFLTELISFELPVYMYIWFAVLFIFSMIVEIVQLA
                     IAKESILNSILKRIGIKILSLLVVLIIGVLGSNFFAQVVEDAVNKESNLAYYILSTSIA
                     TALTIIEPIIETMKKFIKEQSNLAFANFTVSVICLSVTFQAVSSIFSDYFILATPYKVV
                     LIISSAIGIVYLVKFDQNNLEVNSESVHSNKND"
     gene            15079..16836
                     /locus_tag="H8S71_RS01235"
                     /old_locus_tag="H8S71_01230"
     CDS             15079..16836
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015715153.1"
                     /locus_tag="H8S71_RS01235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01230"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_169038003.1"
                     /transl_table=11
                     /translation="MGNNHLLLLLKLVKWPKKILVYILFSLLFTTILSLVIPILTKNTV
                     DQFTDGTVNWAITIMLAGLFLINILLSGLSFYYLAFLGENATYYIRDKMFSHILDLPLT
                     FFDKNESGQIVSRVIDDVELMNTFISDKIPNFASQLIVVAGSLILLFVLDWKITLLMLI
                     SVPISLAVMIPLGNKMYKISLEKQNNMAIFTARISSAFSGIRLTKSYTAEKEEYGKGNV
                     ILKRIFKLNLKDTKIQAYMMPIMSTVILMIILLLVGYGGIRLSEGTISPGTFVAIIFYL
                     VQFVTPLSSLSNFFTEYKKTLGATKRLYEIYSLKTEAENKQISSNAFNLGNGDLKFENI
                     SFQYNDPSSEVFNKLNLRFPKNKITAVVGPSGAGKSTLFNLIERLYEAQNGEIYYESTP
                     IKDIDLTVWRKKIGYVMQDTLMITGTIKENLTYGLSGSVSQETIIKYSKLANAHDFIME
                     LPDNYETFIGERGIKLSGGQKQRIAIARALIKNPEILLLDEATSNLDSESEILVQQSIN
                     RLVRDRTTIIIAHRLSTIRDADNIVFLENGVVTGSGNHLDLINNHEKYREFVNGQLLNN
                     TSISASSLS"
     gene            17038..18015
                     /gene="ybdG"
                     /locus_tag="H8S71_RS01240"
                     /old_locus_tag="H8S71_01235"
     CDS             17038..18015
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybdG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388081.2"
                     /locus_tag="H8S71_RS01240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01235"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_187002029.1"
                     /sec_met_domain="PF00561 (E-value: 2e-06, bitscore: 25.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFVSLAALVLLVSVSGFIYHHFQLNKEAALLKGKG
                     TVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSEVSHDGRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFMPSAVYNPEVIRQSFLTDEEKEI
                     YKAINFKQFFNADMEHELLQSYQNGSKSVNLLAPKETPILILDAVSDQNRHSKYAIQNR
                     KDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR"
     gene            18017..18688
                     /gene="ybdJ"
                     /locus_tag="H8S71_RS01245"
                     /old_locus_tag="H8S71_01240"
     CDS             18017..18688
                     /codon_start=1
                     /gene="ybdJ"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388082.1"
                     /locus_tag="H8S71_RS01245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01240"
                     /product="two-component system response regulator YbdJ"
                     /protein_id="WP_038827940.1"
                     /transl_table=11
                     /translation="MKGYHILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQK
                     VDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRMRNMLEHHYGTFTQIKHLYIDAETKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVK
                     K"
     gene            18685..19671
                     /gene="ybdK"
                     /locus_tag="H8S71_RS01250"
                     /old_locus_tag="H8S71_01245"
     CDS             18685..19671
                     /codon_start=1
                     /gene="ybdK"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003234894.1"
                     /locus_tag="H8S71_RS01250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01245"
                     /product="two-component system sensor histidine kinase
                     YbdK"
                     /protein_id="WP_187002030.1"
                     /transl_table=11
                     /translation="MKLKKKYQLLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMP
                     FHRSFAYPAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLHLFYLE
                     DQCHGQAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDY
                     LYSMSGIELHYKPADQDVRWMSNALWMQRLFDNIFQNTLKHSKAEKMEVTIEHDNVFIR
                     DDGIGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTEFLFSKE"
     gene            19730..19990
                     /locus_tag="H8S71_RS01255"
                     /old_locus_tag="H8S71_01250"
     CDS             19730..19990
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097672.1"
                     /locus_tag="H8S71_RS01255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01250"
                     /product="hypothetical protein"
                     /protein_id="WP_187002031.1"
                     /transl_table=11
                     /translation="MNIICLKKSSKRLSTSQAVLVTDIADIGITAAAGADIIAATAARA
                     KEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD"
     gene            complement(19975..20745)
                     /gene="pkrD"
                     /locus_tag="H8S71_RS01260"
                     /old_locus_tag="H8S71_01255"
     CDS             complement(19975..20745)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pkrD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388085.1"
                     /locus_tag="H8S71_RS01260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01255"
                     /product="protein kinase"
                     /protein_id="WP_032724790.1"
                     /sec_met_domain="Pkinase (E-value: 1.4e-31, bitscore:
                     107.7, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLIYLCTDI
                     LTQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKSIHHPQIPGFIDEFIIDGQAYYVMQF
                     IEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLC
                     LIDFGLAKQLTFEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTK
                     EVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT"
     gene            complement(20831..21688)
                     /locus_tag="H8S71_RS01265"
                     /old_locus_tag="H8S71_01260"
     CDS             complement(20831..21688)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388086.1"
                     /locus_tag="H8S71_RS01265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01260"
                     /product="hypothetical protein"
                     /protein_id="WP_169038000.1"
                     /transl_table=11
                     /translation="MVKKWLIPFAVMLSILSTFTYSASAIGVTAITGNNSFDTAMPIGY
                     WKYKNIDTTILEAGQDEAYFTFTANKGEKVYVRSTYQSAYTGMKIEIYDKNRIPVSQGT
                     EIINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEERIKSGSGTFQFSG
                     VAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHLIMTS
                     ENNEWRRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKIDYEYDV
                     TKQF"
     misc_feature    21745..21754
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            21820..23004
                     /gene="ybdO"
                     /locus_tag="H8S71_RS01270"
                     /old_locus_tag="H8S71_01265"
     CDS             21820..23004
                     /codon_start=1
                     /gene="ybdO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388087.1"
                     /locus_tag="H8S71_RS01270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H8S71_01265"
                     /product="DUF4885 domain-containing protein"
                     /protein_id="WP_169037999.1"
                     /transl_table=11
                     /translation="MRLNRQFIRTQLMAQNILSKNAPAKRENATENPAAVLEKAYSRLK
                     SQSSTGGINQFNYSKISVSGNSGTFSKVYQSANDRTVTDTGEETVIQCQNPYESESDIR
                     IKILDEKYSRMNAINKSKPDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEWLFK
                     GKAQNYNLQDAAFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTELTFT
                     ITPIDYQVRVSGSDDQALIKQIEQVLQSGDNSKELFLHIMKSQSSDSTQFSEEAYQKYR
                     AAREMYEVTGYHLKDLEVIDGRYVTPDGRDLLDVYKEELEKDPVQKQTASYAISYYRSE
                     LSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGVNY"
     misc_feature    23065..23079
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.38"
                     /tool="antismash"
     misc_feature    23085..23098
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     misc_feature    23364..23379
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 20.19"
                     /tool="antismash"
     misc_feature    23535..23549
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    24309..24325
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.42"
                     /tool="antismash"
ORIGIN
        1 ttatttttcc ttttaaaata tgtaggcctt tagcattctt ttcatattta attttaaata
       61 ttgacaggat gaaaaagtat cctaataaaa aaggaagaga aacataagtc gatttatttg
      121 ataatcagga ctatattaaa ggaaatgaaa acatagcata aagtaaagac caataataag
      181 gtagcacttc aaaaaacttc gctgaagtta gttgaagtga agccgacaat tttcaggatt
      241 caatgatcta acataatcat tgaaattttg aagttgtcgg cttttttgtt ggaaaaaaat
      301 agagatgaat aaaaattgaa ataaataata gacaaatatg atctgattga aaggtctttt
      361 gaccaataat gagttttaaa aaagggagaa tttagaatgt tagtttcgct gagtttgtca
      421 tcattattaa cattattttt tattatgttt atggcttctg ggataagtgg actattgttt
      481 ttacatccgc gagtaccctt gagttttgtt cgcattcata ttgggatctt ggctttacca
      541 cttttggttt ccttactgat tcttgccaat agtggtgtga gtggaaatgt tggcccttgg
      601 cacttagatt ccttagcttg tttaatgact ttctttgttc ttgcaattgg attcatcatt
      661 cagcgttttt ctgtacgtta cttaatgggg gatcgatctt atcgaaaata ttttacgctt
      721 tttactttca caacaggtgc tgcttcaatg acatggttaa gtggcgatct ccgcttgatg
      781 gttctatttt ggggagcaac tcttgttggt ttaaccttac ttattaggtt aaacagtgct
      841 tggcaagtgg ctagtgaagc agccaaggtt tctggccgct tatttttgtt aagttggttt
      901 tctctgtttt tcgcaatgat gtggcttttt catgccacag gtcaatggca gttatcattg
      961 gttgtaacaa atgaaagttt agctgggctg ggagaatggg agagaacagg gattcagcta
     1021 ttgattgtat tagcagtgat tattcctgca gctcaatggc cattccaaag atggttggtt
     1081 gagtctattg ttgctccaac ccctgtttct gcaattatgc atgcaggttt agtaaatgct
     1141 ggaggaataa tactaactcg attttcacct ctatttcatg gtggtatcgc ttcgattgtc
     1201 ttacttctgc ttgctggcat ttctgtattg attggaactg gtattagttt agtccaagtt
     1261 gattataaac gtcaattagt aggctccacg attggacaaa tgggatttat gctcattcag
     1321 tgtgcactag gggcctatat agcagccatt attcatctta ttttacatgg tttattcaag
     1381 gctacgttgt ttctacaagc tggttcagca gtagggcgtc atgaagtatc ggctcgtact
     1441 aatgaaagaa catcctattt atgggtcatg gctggtcgga ttttatcctt agttataggc
     1501 gttgcttttt ggctcgctgc tcctggagag gggtatcaat tcattagtgc actgatctta
     1561 gggtggtcat tgtccgtttc ttggactcag cttgtcgctt ttggagaggg ccgaattggc
     1621 cgaattgccg gcttaactgt tttaggagga gcagccctcg tatattttat cattcataac
     1681 cttttctata agtggctgca tacaaccatt tttcaaagtg ttcaacctcc aatgtcagct
     1741 gtcatgattg tcgtatgtct cttactcttt ggcagtgctt taggtacgtg ggttgctcgt
     1801 catcgttctt ccattttttt cgcggtactc tatctttggt tagtccgatt aggtgaagca
     1861 aaaccaaagt cagtagagag tcacccagac taccttaaac aatatatttc ataaggagct
     1921 aatctgagat gggcattaca tccgtattaa cgaaagataa tgtaaaaaag atagatacag
     1981 atattgatgt tcaagaaagg gatcttaacg ttttcattac atctgccagc cgagtgattg
     2041 cgccactttg gcctatttct acatttgctg cacgtaatcc atggatggga cttgaaaacc
     2101 aaccttttga tcaggttgca agttggttga aaaatactcg cgatgttgat atatacccta
     2161 gtgcgtctat gatccgttca gcaaagaata aaggtgagat tgatgaagat tttgtggaaa
     2221 tggggttgca gcgctggctt gattcacatt cttatcacat cccacgggac gtggcagagc
     2281 gattttgtca tgctgcatta aagttagatc ccctgccttc cgacctttta tcatcacatg
     2341 agctggagaa attagtaggt gaatgtagtg gattggatta tatcgagaat gtgtttatgc
     2401 aaccactaag ttcgtatata gagaatcaag atggtgaaag gctagtcaat atactagatc
     2461 atcatgtcat taagtggagt aaattatatc ttgatgactc tcaagcaggc tggacaatgc
     2521 ctaatcgtga ggaaggtttc tatcgtgctt ggcagcatct tattcaatat gatccagcac
     2581 ttagcaaaaa gcagcgagaa agggtaaagg attggccgaa agaggcacat ttggctttac
     2641 agaaagcttt attcgcacta gaaatcccag agtcagaaat ccagacttat cttgaaggtc
     2701 atttactttc attacctgga tgggcaggga tgatgctttg gcgctcccag caatcgagcc
     2761 acgaacatgc actcctaaca gaatatttag cggttcgaat atccatggag tgggctctta
     2821 taaagccata tttacctttg actaatgaac gatctaagaa aacaatttca attgctcccc
     2881 ttatagcagc ttggattcat tggggtgggc ttacattaga agaatggtca cagatgacgg
     2941 ccattgaaca aaacgaatat ttatcatttg cctacagctt tgatgagaaa cttcgcaaga
     3001 aactttggtt agaagcttgg gaacaaacgt acactgatcg attaagccag aagatcatct
     3061 cgaaacaacg tgaaaccggc cgtaaaaaat ctgcattagc tcaattagca ttctgcatcg
     3121 atgtacgatc agaacctttt cgtcgtcatc tagaaaaaga aggcccgttt gaaacgattg
     3181 gtattgctgg tttcttcggg gtgccgattg caacttgtga acttggcagt aaacacagtc
     3241 atgcttcctt gccgatcata caaaaaccgc aaaataaaat aaaagagttc gcagatgagg
     3301 atgtattcaa aaaatacaat caacggaagc aagcaattca ttctttaagc cataccttta
     3361 aaacgatgaa gcagaatgcg ctttcgagct tactactgcc tgagctaagc ggaccttggc
     3421 ttactctgca aatggcagcc cgtagctttg tgccaagaaa ggcgggtcgt ttcattcgta
     3481 atctccgtga ggcttggttg cgcaaacctg atacaaaact ctcgcttcat catgatgcta
     3541 cagaggcaga aatacctgtg ggttttactg atgaagaaaa agtgaactat gctcgccaag
     3601 cattaaaaat gatggggtta acagagaaca tcgcaccatt ggtcgtgatt tgcgggcatg
     3661 gcagtcaaag tactaataat ccttattctg cagcccttga ttgtggtgcc tgcggtggag
     3721 cggccggtgg attcaatgca agagttttag ctgctttatg taatctatca gaggtacgag
     3781 aagttctttt aactgaagga attaaaatcc ctgaggatac ggtttttgcg gcagctgaac
     3841 ataatacaac ggtggatgaa ttacattggc tttatgtacc agagctttcc gaagctgcac
     3901 aagaagcatt tgaacaaatt gaagccgtta tgccgaaagt gagacatcat gtaaacgcag
     3961 aacgtctagc ccaattaccg aatttccaat cgaagctaaa aaatccgaag gctgaggcaa
     4021 accgatttgc ggaagattgg agtgagatac gtccggaatg gggactggct cgtaatgccg
     4081 cctttattat cggtaaacgt gaactaactc aggattgtga tttggaaggc agagcctttc
     4141 tccataatta tgattggaag caggatgaaa gcggtgaact cctagcaaat attattgcag
     4201 gacctggaac tgtagcccaa tggattaatt tacaatatta cgcatcaacg gtagcacctc
     4261 attattatgg cagcggaaat aaagcaactc aaaccgttac tgcaggtctc ggcgttatgc
     4321 aggggaatgc aagcgacttg ttagccggac tgccttggca atccgtcatg gaatcagatc
     4381 acgaggccta tcattctcct cttcgtttat tgatactcat ccaagcacct agagaatatg
     4441 tagaacggtt attaaatcat gactcagcat ttctgcaaaa agttcaaaat ggatgggtcc
     4501 gactggctaa tattgatcca gaaggatgtt gggaaagctg gtaatgatga atctaaacat
     4561 ttatcaaatg gatttgttat tcaaaataaa aataataaac ataaggaaga ggtgtgctgt
     4621 atgaatgtaa accaaaataa aaaagtatta tttttgacgg atattgaaaa cggtttggag
     4681 cctattttac aagaagcgac taacacttct gcagagaata tgttgactat gcaaagctat
     4741 ggtgccagta tttcacatcc ttatggagaa atcatgaggt ctgttatttt tgcgatttac
     4801 caggaagatg ttgaggagat ttttgtagta ggaacaaaag ataagaagac ttccgcaggt
     4861 aatggactaa ctcaacttga aacaatgaaa gataaaatac aaacattgga ttatctcttt
     4921 caaaattgca agcctgaatt ttttggtggt acggtcgatg aatggctaaa tgaaaatagc
     4981 agtgacacca ttgaaaaaag tgttgatatg attcgacatc atcccctagt gccgtcatat
     5041 gttaaagtta gaggtttatt cgttaatcat aatgatggaa aaccctcaat cgtggaggtt
     5101 cctgatgtta aaacaggtca agccatacct gatcattgct tgtcatgatg aaatgcaggt
     5161 tcaacttcta aacaccatac atggtgaaag cagttctaag gagattgtat gagcgctaat
     5221 ttaactgatt ttgtcacgaa aacaatagag gacatgaact cgtttgatcg tgaaaatatg
     5281 gaatgtatga aaaaactaat tagaaaagca attgattttt atcatcttaa atcttatgaa
     5341 gaagttgagg aaacccattc aggaaatgtt cgatttttgc atgtccactc tatgatggaa
     5401 gaaaatatgt tatccaaaat gatagtggtc acaagaaacg gtaaaactga tttggatatt
     5461 gaaggtgtat atgaaggata tgttgtaaga gaatattaat gagatgaaat cacaaataga
     5521 atatgccaat ttttttgctc aggagatgta ttagatatga aaaagtcgaa gggttctatt
     5581 gaatcagaga tcagtaagtc cattactcaa tgggagaagg attatcttgg gcgggggtct
     5641 gtatctgtta agactgatat actgcgggac atgatcatcg tcaatttaaa agggatttta
     5701 acaccagctg aatatgtagt ttgtggatca aaagagggta tgttatctat caaacaaact
     5761 cgttcggagt tagtcgaatc aggtatagaa ggccttaagg atattatctt aaaaataacc
     5821 ggagaaaaag tgaaaagttt tcatactgat ttaagctccc ggacaggtga acgagtgatg
     5881 gtgtttaaat tatgtaatga tctagagaaa aatttggaaa agatcttata atctaaagaa
     5941 aataaatgtt ttgacggtat ggaatttgtt gtgaattgaa cataatgaac tgccgattct
     6001 tttgttttac aattatggca tcattgataa cttttattca tatcctaagc ggacataaag
     6061 agatgtcaat tcatagtata ctgtcttgtt attcctgtcg aaagatctaa catccgctgt
     6121 tgttatgagc ggatgttttt ttacatctat tttaaataca tgaatttgat gctggtgatt
     6181 agtcacttga acaatatttg aaaaaatcct tgtcacctgc cgggttcccc caagtgttta
     6241 gtgacacgat tatgagacca atttcgtaaa gcttgatgat aaatttaagc ggtgaacaaa
     6301 attgatatgc tgtcttcagt ttcatttcac ggaattagct ttaattaaat atatccaaaa
     6361 aacggattga catatcgaaa tataacgata taataatcga tatggaacca attgaagtat
     6421 tcaaagcctt atcaaatgaa tcaaggctgc aaattttgca atggctgaag gaaccggatc
     6481 gtcattttgc accccatgaa gggattgata tgaacacaat cggggtatgt gttagtcaaa
     6541 tcacagacaa attgaaaatg acgcaatcga cggcttccca atatcttacc atccttttaa
     6601 gagccggcct aattaaggcg gagcgaatcg gaaagtacac gtattacaaa agagatgaag
     6661 aagccattgg gaaacttgct gactttctta aaacagagat ataaaaataa acatcaaaag
     6721 atgtttattt ttacaccata catatcgaca tattacgatg tgtttatttt ttataataac
     6781 atatcgataa ttcgcgatat gtttattaat aattgaggag tgaatgtttt atgtctaaca
     6841 cttggaaaat ttatatttta gccattgtca gctttttagt tggaacctca gagtacatca
     6901 tttcgggaat tttggatcaa attgctcata ctctcgggat cactttagct gccgcgggcc
     6961 agctcattac cattttctca cttgtatatg ctctgtctac acccgtactt atggcgttga
     7021 cagcaagtat ggatagacgc aaattgatga tgtatgccct aggtttgttt gtgttcggta
     7081 atgtcctggc ttttgtactg cctggttatg gatggtttat tgcagcgcgg atcattatgg
     7141 cgatgggagc aggtgtggtt gttgtcaccg cattaacgat tgccgctaag attgcatcgg
     7201 aagggaagca gggcagtgcc atcgctacgg tcgtgatggg atttaccgct tctttaatca
     7261 taggtgttcc gcttggaaga atgatagcag tagcattagg ctggaagtct gtatttggtg
     7321 ccattgcttt gttgggattg atcgcgatgg tcgttatttt ctttactctt ccgcatactg
     7381 aaggggataa gcctgtgcct ttgcttcaac agcttgctct tttcaaaaaa cggaaagtgg
     7441 ctatgggatt gtcaatcact ttcttctggc tcgggggata ttctgttgct tacacttatt
     7501 tgtcaccgta tctcttgaac atctcaggta taaatggcaa gctgctcagc ggtgttttgc
     7561 ttatatttgg aattgccagt ttggttggat cgaagtttgg gggatatagc accgataaat
     7621 ggggagtttc ctttacactc gttggcggga tgacgttgca tatcgtcaca ctgattctgc
     7681 tgtcacttgt tactcattcc tatatcggag tgttggtgat tcttatatta tggtcgtttg
     7741 ccgcatggtc caccggtccg acacagcaat ttcacctggc tacaatagaa ccggaaatgt
     7801 caggtgtttt gcttagcatg aatcagtcaa tgatgcaatt cgccatggcg gtcggcgcag
     7861 gaataggagg ggtttttgtg gaaaacgtat cattgacctc gattacctgg gttggtgcgt
     7921 taggggttat gattgccatt attgcatcat tgctgatttt caattcgcaa ccgaaacaag
     7981 cgctaaaaga tatcaatcaa taatttcgaa agttctaaca tccgctcgtt atacaagcgg
     8041 gtgttttttt aagcgttcaa agtcagtcct gcatgagccg tccaagggcc gacatcgttc
     8101 tgtatgtgtc gaaggcgcac tggagctgaa agagatttct taaggctttg ccggcggcga
     8161 gctgaagtac ggtacgattg ccttgatcga acactggaaa cacaagagca tgtaaacctg
     8221 aacatccgcg taaacgtcaa ggaagttgcc acttggggag taaacacttg catcatctcg
     8281 ctgaaaggcc tagacaatgc ggatgacata ttcgtattgc cggaagtaaa cacagcgctt
     8341 gctcttttcc gttgtcgatt gcagctgatt gcttactaat gctgccctgc atctcggttg
     8401 tgatgtcgat aagcagcgta accttgtgaa gagtgttact gtggagtaag atgtttaacc
     8461 cctttggata ttgatcaaaa ggttttttaa tacttataaa ctgaaggaga tcaattttaa
     8521 atcgttttaa aactattaaa ggaagtttag taacgataac ttaaacatct ggctaataag
     8581 attactgagg atacatcaaa agtcgaatag taatagtaga gagtaaaagt aaccgtaaga
     8641 agaattataa caattagtta gcaaataatt aaaaaatgtc ccaaaaaaag tattgactaa
     8701 ctttttttgg gatagtacta ttgaattgca accggttgaa agtatcaaaa aaaggaggaa
     8761 atggaaatgg agaagaataa tatttttgac ctagacatta ataaaaagat ggaatctact
     8821 agtgaggttt ctgctcaaac ttgggctaca atcggaaaaa ctattgtgca gtctgtgaaa
     8881 aaatgtagaa catttacttg tggatgttcg ctaggctctt gcagtaactg taactaatta
     8941 ggggatgagc agagggagtt aaaatacata ctatatttaa aactccctct tcttctaaag
     9001 acaaggagta aacaattcca taaatatgaa tatgactaca aatgctttac ctaaccaatt
     9061 ttcttggaac tcttataaag taacaaatgg atacaggcta tatgatcttc aagttgggag
     9121 tcctttaatt aagatagctg taattgatag tgggtatgat cctaatcatt ccgagattac
     9181 tggaaatatt gataaaaaaa aatcttgttc attcgttgat tatgagaatt ttaatgaaga
     9241 tctatatggg cacggtacag ctgttattag tgtgattgta gggaaaaatc aagttaaagg
     9301 ggtagctccc ggaattacaa ttattagtta taaagttctg gatagaaatg gttttgggaa
     9361 aatagaatgg gtaatacatg ctattttaaa agccattgaa gattgtgtcc acattataaa
     9421 tttaagtcat gtttttacta tgttcggatt gggaaataaa ggagcattca ataaacttca
     9481 gcaggccatt aataaagcca gaaagaaagg cataataatt gtaggggcag cagggaatca
     9541 aggagtttta ttagatatga agagcacaag tttataccct acaattaagg gaattaacta
     9601 tgtcacctca acaaataaaa ataattacac ctcatcttac gcaaatattg ggtcaattat
     9661 tcgatttgct gcaccatcag gggaacttga tgaaacaaat aatgttacag acttaataat
     9721 agttgcacat cccacaaatt ttccaaaaac aaagtttgaa aaagcaattg ggcttccgga
     9781 cttttataca gttacatgtg gaactagtat atcagcagct atgttttcga gtctaatagc
     9841 attagtattg actgaatatt tgatatgtaa gcaaattcac ctatcagaaa aagaaattct
     9901 taatataatc caaaaaaact cctcacgagt aaaagatcaa aattctattt tcgaaataaa
     9961 tgcttatagt gtaataaaat ttatcaaagg attgttataa atgaatacaa aatatttaag
    10021 ctcagacttg tttatgtata gaaagccgat attggactta tcgttttata aagagtgttt
    10081 agcttttgat aatgaattta acgaagagga atacatagcg aagataagta acttgttaaa
    10141 cactaatccc actatagcag aggccattta ttttgcaagt gaaccactat ataattcttt
    10201 tttaaatata gaaaaattaa aaaagaaaaa gcgcaagagt gttattgata gtatgctaaa
    10261 gtttttaata agaatgagta ctagaccaac tccatttggc cttttttcag gtattggggt
    10321 tgaaacattt tcaggtcagg atgaatcttt aactaaagat tctgaagtta taaaaaatac
    10381 tcgtttggat atgtgttgga tctatttctt aataagaaaa ttagagagta accttagtat
    10441 tctcgagcag ttaactgtgg aaaataactc actggtttat aatcacggtg atagaatcaa
    10501 attaagttat caaagtctat tacacagtga cgataatgat cagtcattag aaatgttaac
    10561 ccttagaaag acagcagtaa tggattatgt ctattcgcaa gcagaattcg gtatcaatta
    10621 ttctacgtta agagatagta taaataaaac atatagtgtt actgatgaca tatcaaatga
    10681 ttttttaaat agtctattaa aaaatgaagt tattataact aacttaagaa catctcttgt
    10741 taattctgat ccttttgaaa atatattaaa cataattagt aaaatgcata atgtagagga
    10801 agaattgaat tatttagttc gattaaaaaa atcgattgaa gaatataaaa aatcttctgg
    10861 ggaattaggt ataagtattt taaagaaaat caaaaaggaa atgcgagtaa taggatacga
    10921 aggggatgat ttcctcagaa cagatttgta ttatgtgaaa aataaaaaac gatatattaa
    10981 taataaccaa aaagatagta tagagaagtt agctgagatt ctttctctat taggatcagt
    11041 aaactctttc caacctttag aagcttatag agatgagttc attgataaat atggtatttt
    11101 tcaagaggta cctctcctcg aactcataga tgaagaatta ggtattggtt taccacctga
    11161 atatcatgaa aacaggcata aaccctcaca accagaaccg agtaatgaat ttcataggat
    11221 aaaaaatatt atatcttctt ggcaagcgga ggtgagttta tccaaaaatc atgagattaa
    11281 attagatgat gaaaagatta aacatttatt taactcggaa gaattaaata acattgcggt
    11341 atcacaagaa ttagaacttt attttaatat tttacttgat gaacacaaag aaaataaact
    11401 ctatttaaat cctaactgtg gttctaattc tctgtttcaa acatatggaa gattcaaata
    11461 ttttttgggt gaaagtgata aagagtacat aaaacaattt tcacatatag aaaaagatgt
    11521 tatttttgca gaggttacgt attatcctac ccatggaaaa actgctaaca ttataaatgc
    11581 tgaaacatgc tttgattatg agatagcttt tagctgtaat tcgtccaaag ataataagca
    11641 ctcaattgcg ttgtctgact tatacgttgg gtcaacatat aactttattt atcttaagtc
    11701 aaaaaaattg gataaaatca taataccaaa attaagtcat atgtttaatt attcaatggg
    11761 ccctaaaatt tatagatttc ttgttgatat tggtgttcag tatcaaaaac aatggtctaa
    11821 tatagatagt ttcttttatg atgctccaat taaaccgagg gttatatata ataatattgt
    11881 attatcacct aaaaagtgga acttaaataa aagtattatt ccatttgaat gtgactctag
    11941 agaaaaattc cattactata taaaagattg gaagaagaga tataaggtac ctgattttat
    12001 atatttaata gaatttgata ataaacttct gctgaactta gaaaatatct cacacattaa
    12061 aattatctat aatgaattta agaagctttc gaataatcaa tcactacaat ttttagaagc
    12121 agagaaagag ttgtttaata gtcataacaa tgaaatagaa gaatacgttt ttactttaaa
    12181 gtcaaagtta catcaattag aacttgattc ttatatgaca aatattcaga gtgaaatgcc
    12241 ttttaaatat actagtgaca atgaaaggct taaattctta ggtacagaat ggatttatgt
    12301 gaaattatat ggattaggca ctagagaaaa tgaatttata gctgatgaac ttggctcgtt
    12361 tataaaaaaa catttagata taggtactat taagtctagc tttttcatta gatatagtga
    12421 ccctaagcag catttacgtg ttagatttaa agttgaaaag aacaacattt tcgatactgt
    12481 actcccgatt ataataaaat ggttagaaga aatgagagca aagggttttg ttaattatta
    12541 ttgtttcgat ccatacaacc ctgaaataga aagatacgga ggggaacaat cacataagat
    12601 tgcagaagat ttattttttt gtgactcatt gattgtttct gagtggatac aaattaatag
    12661 atctggaaat gttaatattg atgaagtgac ctttggagtt tttaatattc ttcaactatt
    12721 aaaattattt gatttaaata ttgaagagca aatgacatgg ttagaaatta atacaaaacc
    12781 gcagaaatac gctaatgaat ttagagggaa aaaaagtact ttaattgagc tggcagactt
    12841 aatctatact aataagaaac ttgataaata taataaaatc tcaagtatta tagagatacg
    12901 agaaaaagct gcaatcacct attctaagag catagaaaat aatccagatt tcttaataaa
    12961 aaatattata atgagtgtaa tacacatgca ttgtaacagg ttatatggaa taaacaggga
    13021 caaagaaaac ttagttattg ggttagcata tcataccatt aaaaattata ataatgctct
    13081 aaagtataat aatgttttaa tccctaacta aattttaatt gaaaggaaag aattaatgca
    13141 gaaatgcaag aatcaagatt ttttaaccga tatcctttta gatatagcta attcaattaa
    13201 agataagtca gaaaccgaaa aaataatact tggtgatcga aataatcctg aagatataat
    13261 tgaagtagta tcattggcag caggatatcc aggaatttgt gtgtttttag gttatatgga
    13321 taaagttttc cctgaagatg gatgggatgt tgtggcacac gactatttaa cagatttaat
    13381 ttccttaatt cagactaata aaacatactc tctatctcta tttaatgggt tggcaggtgt
    13441 tttagtggct cttgaaactt gctctagggg cggaacaaga tatactaaaa taataaatca
    13501 agtgctgacc ctaattttag aaaactataa acattatttg tctgaggact tgttgaagct
    13561 aaagaaagag ggagtgtccg cttctgaata tgatgttata agtggttgga caggtgttgg
    13621 aagaacccta ttgcattttg atcaaatatc aaataaagga gacatttcat taaaaaaagc
    13681 attgcatgat atagcagaat atttactgtt agtaagcagt attgatactc taagtaatat
    13741 gccaaattgg cttatatcca atgaaaacct tcctttagat atcgagaaaa aaacttataa
    13801 aaaaggatat tttaattctg gcatggcgca tggaatttct ggagttttag catttttatc
    13861 gatcctgaaa aaagaaaact ataaaataaa gaatttagaa ttaggtatta aaaacattca
    13921 aaattggata tttgaaaagg taaaaacaca caaaggaatt tattatatac ctaatgtaat
    13981 tgaaaatgaa gttgttagaa atgaggcttt ttttaaccac agagatgcct ggtgctatgg
    14041 tacaccaggt gtgtcaagag caatcttttt atcaggtata gctttgaacg atcaaagagt
    14101 taaaatgaaa gccctagaac tgtttaagac atttttttta cgtgatgaga aagatagaaa
    14161 aattatatcc cccacaattt gtcatggata tgccggcata ttaatgttga ctttaagaat
    14221 gtataaagat actaatgacc gatttctagc tgataaaatg catgatatac ttaatgaaat
    14281 gttaactttt tactctcaat taaacttttc caaattcaat aattatgaat taataagtgg
    14341 gaaaattgta gaagagaaaa aagtgggttt gttagaagga agtacgggaa ttgccttagt
    14401 tttaatttct ttcatttttg gtcaagattc gtgggacaag atatttctga taagttaaag
    14461 ggggataaaa ttgatacaag cagtattaga aatcactatt aaatttctaa cggaattaat
    14521 ctcttttgaa ttgccagtat atatgtatat ttggttcgca gttcttttca tattttcaat
    14581 gatagtcgaa attgtacaat tggcaatagc taaggaaagt atattaaatt ctattttaaa
    14641 aagaatagga ataaaaattt taagtttatt ggtggtctta attattgggg ttttaggatc
    14701 aaactttttt gctcaggttg ttgaagacgc agtcaataaa gaatctaatt tagcttatta
    14761 tattctgtct acttcaatag ctacagcatt gaccataatc gaaccaataa ttgagactat
    14821 gaaaaaattt ataaaagaac aatcaaatct tgcttttgca aattttacag tcagtgttat
    14881 ttgtctttct gtaacgtttc aagcagtctc aagcatcttt agtgattatt ttattttggc
    14941 caccccttat aaagtggtgt taataatttc atcagcaatt ggtattgtat atttagtaaa
    15001 attcgatcaa aataatttag aagttaatag cgaaagtgtt cattcaaata aaaatgatta
    15061 atctaagagg ttatacatat gggcaataac catttactat tactgcttaa acttgttaaa
    15121 tggccaaaaa aaatattagt atatatttta ttttcattgc tatttacaac tatactatcc
    15181 ttggtaatac caatattgac taaaaatact gttgatcaat tcactgatgg aacagtaaat
    15241 tgggccataa caataatgtt agcaggttta tttctcataa atattttatt aagtggatta
    15301 tctttttatt atctagcatt tttaggtgag aatgcgactt actatatacg agataaaatg
    15361 ttttctcata ttttagattt acctctaacg ttttttgata aaaatgaatc tggtcaaatt
    15421 gtaagtagag ttatagatga tgttgagtta atgaatactt ttatttctga caagatacca
    15481 aactttgctt ctcaattgat agtagttgcc ggatcattaa ttcttctgtt tgtgctggat
    15541 tggaaaataa cattacttat gttaatttct gttcctattt cattagctgt tatgattcca
    15601 ttggggaata agatgtataa aatttcttta gaaaaacaaa ataatatggc aatatttact
    15661 gcaagaataa gtagcgcatt ttcaggaatt agacttacaa aaagttatac tgcagaaaaa
    15721 gaagagtatg ggaaaggtaa tgtcatttta aaaagaattt ttaagcttaa tctaaaagat
    15781 actaagatac aagcttatat gatgcctatt atgtctactg ttatactaat gataatatta
    15841 ttgttagtgg ggtatggggg gataaggtta tccgaaggaa ctatttcacc aggtaccttt
    15901 gttgcaataa ttttttactt agttcaattt gttacacctc tttcctctct gtctaatttt
    15961 tttactgaat ataaaaaaac actaggtgca acaaaaagat tatatgaaat atattcatta
    16021 aaaaccgagg ccgaaaataa acaaattagc agtaatgcat ttaacttggg aaatggggat
    16081 ctgaaatttg agaacatttc gtttcagtat aacgatcctt cttctgaagt atttaacaaa
    16141 ctgaatttgc gttttccaaa aaataagata acagctgttg taggtccttc tggagctgga
    16201 aaatcaactt tatttaattt aatagaacgt ttgtatgaag ctcaaaatgg tgaaatctat
    16261 tatgaatcaa ctcctataaa agacattgat ttgactgttt ggagaaaaaa aattggttat
    16321 gtaatgcaag atactttgat gatcaccggc acgataaaag agaacctgac gtacggttta
    16381 tcaggctctg tatctcaaga aactataatt aaatattcta aattagccaa tgcccatgat
    16441 tttattatgg agcttccaga taattatgaa acctttattg gagaaagggg tataaaatta
    16501 tcaggtggtc aaaaacaaag aattgcaata gcaagagcat taattaaaaa ccctgaaata
    16561 cttttattag atgaggcaac ttcaaattta gacagtgaaa gtgaaatatt ggtacaacaa
    16621 tctataaata gactagttcg agatagaacc actattatta tagctcatag attgtcaaca
    16681 attagagatg cagataacat tgtattttta gaaaatggag tggttacagg aagcggtaat
    16741 catttggatc taataaataa ccatgaaaaa taccgagagt ttgttaacgg tcaattgcta
    16801 aataacactt caataagcgc gagttctcta agttaattgt gcataaataa tgagaccact
    16861 tgggtacact ttttatcagt tctataacca taaaaagcag ctgaactttt agttcagctg
    16921 ctttttgatt gaatcttgcg actagaaagt caaatgtgaa aataaaactg tgccaaagtt
    16981 aatcagaaat ttattttcat attgtatcct ttcagtatca agtgaaagga gcatcatatg
    17041 aaaacattat ggaaagtcct caaaattgtt tttgtcagct tggctgcttt ggttttgctt
    17101 gtatccgtct cgggatttat ttatcaccat ttccagctaa ataaggaggc ggcactgctg
    17161 aaaggtaaag gcacagtagt cgatgttgac ggtaaaaaga tgaatgtgta tcaagaggga
    17221 agcgggaagg atacgtttgt gtttatgtcc ggttcgggga ttgctgcgcc tgcttatgaa
    17281 atgaaggggc tgtacagcaa gttttcaaaa gaaaataaga ttgctgttgt agatcgggca
    17341 ggttatggat acagtgaagt gtctcacgat ggcagagata ttgatacagt attggaacag
    17401 acgaggaaag cgcttatgaa aagcggaaat aagcctcctt atattttaat gcctcattcg
    17461 atatccggga ttgaagcgat gtattgggca cagaaatatc ctaaggaaat caaggccatt
    17521 attgcgatgg atattggatt gccccagcag tacgtcacgt ataagttgag cggagttgac
    17581 agattgaaag tgagagggtt ccacctgtta acctcgattg gttttcatcg gtttatgcct
    17641 tccgctgtat ataatcctga ggtgattcgg cagtcgtttt taactgatga agaaaaagaa
    17701 atctataaag ccattaactt taagcaattt tttaatgcag atatggagca tgagctttta
    17761 cagtcttacc aaaacggcag caaatctgtg aatctgctgg caccaaagga gactcccatc
    17821 ttgattttag atgcggtctc tgaccaaaat agacattcaa agtatgctat acaaaaccga
    17881 aaagactatg aagcgtttgc ggctcaattc aatactgccg atataaagga actgagggga
    17941 acacacagta tttatttata tcagcctgat caaatatata aactttccat ggagtttatg
    18001 agaaaggttc gctaggatga agggttatca tattttaatc gttgaagacg atgtgatgat
    18061 tggtgatttg ctgcaaaaga ttttgcagcg tgagggatat cgtgtgatat ggaaaacaga
    18121 tggagcggat gtgctttcgg tgattcagaa agtggatttg gtcattatgg atgtgatgct
    18181 gccgggtgaa gacgggtatc aaatgtctgc aaaaatcaaa aagctggggc tgggcattcc
    18241 ggttattttt ctctcggccc gcaatgacat ggacagcaag cttcaaggtt tgcagatcgg
    18301 cgaggattat atggtaaagc cctttgatcc gagagagctg ctattaagaa tgcggaatat
    18361 gcttgagcat cattatggca cctttacgca aatcaaacat ttgtatattg atgcggaaac
    18421 gaaaaaagtg ttcaatgaaa gcctgcatga tgaggtattg tttactgcga ttgagcggaa
    18481 aattttcttt tatttatatg aaaatagaga tagtatcctg acaaaggaac atttctttga
    18541 atatctatgg cagctcgaag atagaaatcc gaatattgtc aatgtgcata ttaaaaaaat
    18601 cagagctaaa atcaatgatc aagcgggtga gatgattgaa aatatatatg gagaagggta
    18661 tcggctgaat accgttgtga agaaatgaag ctcaagaaaa aatatcagtt gttattgttt
    18721 acggcagtca ttagtgttcc gatgctattg ctggcggtca gtgttttgat gtcggtaatt
    18781 tatgacagca tgtttaaacc gatgaatcat ggtatgccct ttcacaggtc gtttgcgtac
    18841 ccggcaatga tcgttgtatt tttgatatca ctcttattgt tagctttttt attttcaaag
    18901 tcgattcatt ctctgttaca taaaatcaat ctattaaatc aaaccattcg gcatttggcg
    18961 agtgatcaaa gggtgcccga taaaattgaa gtgaagcgtg cggatgaaat cggggaactg
    19021 atcaagtcgg tcaatttgtt aattgaacgg acgacatatc gtgaactgga gctgagacag
    19081 caggaggaaa tcaaaaagga gcttttgcaa aaactgcggc atgacattaa tacaccttta
    19141 acggctctca ggttgcattt attttatttg gaagaccaat gtcatggtca ggctgtattc
    19201 gaatcattgt atcagcaaat cgaatatatc tcggaattaa ccaatgaatt caatctatat
    19261 tccgctgaga cgctggaaag ctcttatatt gtaaatgaag aagtgcgtct aaacgagcta
    19321 ttagaaacag cggtgaaaaa gtgggattat ttatacagta tgagtgggat tgagctgcac
    19381 tataagccgg cagatcaaga tgtgagatgg atgagcaacg cgttatggat gcaaaggctg
    19441 tttgataata tttttcaaaa tacgttaaag cattcaaaag ctgaaaagat ggaagtcacg
    19501 attgaacatg acaatgtttt tattcgtgat gacggtattg gatttgatcg gaatgagagc
    19561 agtgagggac ttgggttaaa gattattgag gatacatgca ggctgcttgc gattacttat
    19621 gagctgcata caaatgataa cggaacggag ttcttgtttt caaaagagtg accctgctga
    19681 tgtttttctt tctcctataa aatttatata atagggagaa agaaatgggg tgaacatcat
    19741 atgtttaaaa aaatcatcaa aacgattaag tacctctcaa gcagttctag tgaccgatat
    19801 cgcagacatc ggcattacag cagcagccgg cgcagacatt atcgcagcta cagcagctcg
    19861 ggcaaaagaa gacactacga ccgttatggc ggcagtcatc gttacaaacg ccggagctac
    19921 agcagcagtt aatccaaaaa aagttcttgt tccgcttttg ggacaagggt ttttttatgt
    19981 gaccgattga atggcccggt ttagatcctc gcgaatggaa gcggtgtgct gatactcttc
    20041 ctcaatgccc aataatcttt tcagcagcag ggttacttcc tttgtcagtg ttaattcctc
    20101 cagccaagtg ccgtttttct tcttttttcc tttatattga gagtacagca gaaataacag
    20161 cgtttctccg agatcgaaga agtcatcctg ttttcgtacc tttatttcct ccatttcttc
    20221 aaaagtcaat tgtttggcaa ggccgaaatc gatgaggcag agcctgccgt cattgatgat
    20281 gatattaggc gttctgatgt cgctgtggaa gataaggcga tcatgcaggt attctataat
    20341 ctcaagcagc tgcgaaatca gttgtaacgc cataagctct gtgaacggct gttttcgaaa
    20401 aaataataat tcttctatat tctctccctc gatgaactgc atgacataat aagcctgtcc
    20461 gtctatgatg aactcatcta tgaagcccgg aatttgcggg tggtgaatgc ttttgagcag
    20521 ttttatttcc tgttggaatc ggactttctc tttttccttt ttcgcttttg tcggccgaag
    20581 ctgttttaaa acataaggtg tttgagttag gatatcggtg cacaaataaa tcaaaccgta
    20641 gcctcccata ccgaggcact cttcgatttt gtattgatga tttaagataa cgccgttctt
    20701 tagagggcgg tcaaaaagca gtttttttag aagttttaat gccatgtctg cacttccctt
    20761 ggttgtactg actatagttt accttctaga cggagaataa aaaagagccg gataaccggc
    20821 tcggtataag ttaaaactgc tttgtcacgt cgtattcata atctattttt gcttttacgt
    20881 tgctcatcgt cgatctggct gtcgctaatg tattatattt aaaactccat acctttgcca
    20941 cactgagttg atctgacaaa gagatatcat aagaccctga agtcgagctg tttacaagag
    21001 cacggcgcca ttcgttgttt tcgctcgtca tgatcaggtg gcgtgtattt ccctggcttg
    21061 gtgtttgagt ggcggttgtc tgaactctgg ttacaatggc atcacgcggt atcccggatt
    21121 ggtttgttaa atcaaccttg atcacgctgg aatcagaacc tgaggggcta aggcttgtat
    21181 ttcctttatt ttcagcaacg ccgctgaatt ggaatgttcc gctgcctgat ttgattcgtt
    21241 cttcaattga aagtgtaaaa tacatgtttc cggtataggt gcctcgtgac actttcacat
    21301 aaaaggtatc tgtcgtgttt tgggcgtctg catttgcata aataaaagaa gaaaacgtat
    21361 tagggttaat gatttctgtc ccttgagaaa caggtattct attcttatca taaatttcaa
    21421 ttttcatccc tgtatacgcg ctctggtatg tactcctcac gtatactttt tctcccttat
    21481 tagccgtaaa agtgaaatag gcttcatctt gtccagcttc cagtattgtt gtatcgatat
    21541 ttttatattt ccaataaccg atcggcattg cggtatcaaa tgaattgttt cctgtgatag
    21601 cagtgactcc gatagctgat gccgaatacg taaaggtgga taagatagac agcataacag
    21661 cgaatggaat aagccatttt ttcaccatgc aaacaacctc cttttatttc catcatacat
    21721 aataacgatt taagtgtaaa taaatgtttt ttgaggttaa tatatacatt atctttaccg
    21781 ataaaaaaga ataagagaga atactcggga gggaattcaa tgcgtctgaa tcggcaattt
    21841 atccgcactc agctgatggc acagaacata ttgagcaaga atgcgcctgc caaacgggag
    21901 aatgcgactg aaaatccagc ggcagttctg gaaaaggcat acagcaggct taagtcacaa
    21961 tcttcaactg ggggaatcaa tcagttcaat tattctaaaa tcagcgtgtc gggaaacagc
    22021 gggacattca gcaaagtgta tcaatcagcg aatgatcgaa cagtgacaga cacaggggaa
    22081 gaaacagtga ttcaatgcca aaacccctat gaatctgaga gtgatatcag aatcaaaata
    22141 ctagatgaaa aatacagcag gatgaatgcg ataaacaaat caaagcctga tcccttaggc
    22201 tatattaagg ataagtacca aaattcaaag tctccttatt tcagaagtga tctgtcagct
    22261 gcagaaagac aggccgcata cgataatgaa acagaatggt tattcaaagg caaggcgcaa
    22321 aactataacc tccaggatgc tgcgtttcgg aatgtcacat ttcatgggga agtggaagct
    22381 gagaatgaaa aggtgtatca gcggggacag gttaaccagc agctgcaagt gctgttgaat
    22441 cgaaaccata ttcatattcc agaggggaca gagctgacgt ttacaatcac accgattgac
    22501 tatcaggtgc gggtaagcgg gtcagacgat caggcactga ttaagcagat tgagcaagta
    22561 ctgcaatctg gggacaacag caaagagcta tttttgcaca tcatgaaaag ccaaagcagt
    22621 gattcaacac aattttccga agaggcctat caaaagtatc gggctgctcg tgagatgtat
    22681 gaagttacag gctaccattt gaaggattta gaagtgattg atgggcggta tgtcacgcct
    22741 gatggacgtg acttattaga cgtctataaa gaagaacttg aaaaagatcc agtgcagaaa
    22801 caaacggctt cttatgctat atcttactat cgttcagagc tcagtaaaat cgcggaagcc
    22861 gggtataatg ccattccgga tttcatccta tcaattgatt acagcaatgg atctctgaga
    22921 gatgtgggac aaagcaagag ctatgggacc ggagataccg ggtggcttga agcattaaag
    22981 cgtcaaacgg gtgtgaatta ttaggtaagc tgttcatgta gaacagctta ttttttatga
    23041 gaatctaagg ggtgtattaa tttaaatatt caaataattt tattattttt atataaaaga
    23101 ttttaaaaga agtgaacgat tcaaaactct gaacaaaggt gtttacctga aaaaaacaat
    23161 tgtattttcc agagaaattt attatgatga aataagtaat ttaggagatt atataacaat
    23221 tttaagtttg aattttctga ttgttatcgc tgattcatgt gaaggcaagc aggtctgctg
    23281 ttttctcatt tatgttagga ggaggaagag gagtggcaaa taaagaatta aagaggggcc
    23341 tgggcgcgcg ccatattcag atgatcgcct tgggcggtac aatcggtgtt ggcttgttta
    23401 tgggttctgc cagcacgatt tcatggactg gcccatctgt ccttctggct tatgcaatat
    23461 gcggaatttt tatctttttt attatgcgtg cgatgggtga aatgctgtat gtcgagccga
    23521 gcacaggctc ttttgcgacg ttcggccatc aatatattca tccgatggca ggttatataa
    23581 cagcatggag caactggttc cagtggatta ttgtcggcat gtcagaaatt atcgctgtcg
    23641 gttcttatat gaagtattgg ttcccggatt tgcctgcttg gatacctggt atcgtggcaa
    23701 tggtgattct tggtgcggcg aatttaattt ctgttaagtc gtttggggaa tttgagtttt
    23761 ggtttgcgat gattaaaatc gtgacgatta tcttgatgat tattgcggga atcggaatta
    23821 ttttcttcgg ttttggcaat ggcggagatg cgatcggttt gtcgaacctg tggtctcacg
    23881 ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc actgtctctt gtcattgcgg
    23941 cctatcaagg agttgagctg atcgggatta cagcgggtga agcaaaggat ccgcaaaaca
    24001 cgctaagaaa tgcgattcaa agtattatct ggcgtatttt gattttctac attggcgcta
    24061 tttttgtgat cgtgacggtg tatccttggg atgagctcaa ctcactcgga agtccgtttg
    24121 tgtctacgtt ctcgaaaatc gggattacgg cagcggccgg cattattaac tttgtcgtga
    24181 ttactgcggc aatgtccggc tgtaacagcg gtattttcag cgcgggccgc atgctgtata
    24241 cactgggtgt caatggacaa gcaccgaaat tctttaagaa gatttcacgc aatggtgtgc
    24301 cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt cggtgttgta ctgaactata
    24361 tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag cgtgctccca gggatgattc
    24421 cttggtttat cattttgatc agccatatcg gattcaga
//
