LOCUS       NZ_CP045704            21827 bp    DNA     linear   CON 03-SEP-2024
DEFINITION  Streptomyces rutgersensis strain NBH77 chromosome, complete genome.
ACCESSION   NZ_CP045704
VERSION     NZ_CP045704.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces rutgersensis
  ORGANISM  Streptomyces rutgersensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces diastaticus group.
REFERENCE   1  (bases 1 to 6848830)
  AUTHORS   Benaud,N., Edwards,R.J., Amos,T.G., D'Agostino,P.M.,
            Gutierrez-Chavez,C., Montgomery,K., Nicetic,I. and Ferrari,B.C.
  TITLE     Antarctic desert soil bacteria exhibit high novel natural product
            potential, evaluated through long-read genome sequencing and
            comparative genomics
  JOURNAL   Environ Microbiol 23 (7), 3646-3664 (2021)
   PUBMED   33140504
REFERENCE   2  (bases 1 to 6848830)
  AUTHORS   Benaud,N., Edwards,R.J. and Ferrari,B.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2019) School of Biotechnology and Biomolecular
            Sciences, University of New South Wales, Botany St, Sydney, NSW
            2052, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2018
            Assembly Method                   :: FALCON v. v 1.8.6
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 62.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014216335.1-RS_2024_09_03
            Annotation Date                   :: 09/03/2024 04:34:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,921
            CDSs (total)                      :: 5,831
            Genes (coding)                    :: 5,642
            CDSs (with protein)               :: 5,642
            Genes (RNA)                       :: 90
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 189
            CDSs (without protein)            :: 189
            Pseudo Genes (ambiguous residues) :: 0 of 189
            Pseudo Genes (frameshifted)       :: 102 of 189
            Pseudo Genes (incomplete)         :: 130 of 189
            Pseudo Genes (internal stop)      :: 14 of 189
            Pseudo Genes (multiple problems)  :: 50 of 189
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:08:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 92321
            Orig. end                         :: 114148
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045704.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Belinda Ferrari, QAP Lab
            4002, Bioscience South E26, UNSW Sydney, Australia 2052 (Quarantine
            regulated isolate).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21827
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21827
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21827
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11827](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11827
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    552..567
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.69"
                     /tool="antismash"
     misc_feature    complement(603..617)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
     gene            1096..1674
                     /locus_tag="F0345_RS00405"
                     /old_locus_tag="F0345_00425"
     CDS             1096..1674
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163: rhodanese domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383191.1"
                     /locus_tag="F0345_RS00405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00425"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_100457165.1"
                     /transl_table=11
                     /translation="MTTANDTTFTPAALQHLIKTGQAPRLLDVRTPGEFQTSHIPGACN
                     VPLDTLREHRMELGRHLDENVVLVCRSGARATQAEEALADAGLPNLRVLDGGMMAWEAS
                     GAPAIRGPQRWELERQVRLIAGSVVLVSGVVGFFVPGVHLIGTAIGAGLTFAALSNTCA
                     MGMMLSKLPYNRGPRTDIHTVITSLRDRS"
     gene            1671..2642
                     /locus_tag="F0345_RS00410"
                     /old_locus_tag="F0345_00430"
     CDS             1671..2642
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383192.1"
                     /locus_tag="F0345_RS00410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00430"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_100457164.1"
                     /transl_table=11
                     /translation="MITVVLAASVLIGISLGILGGGGSILTVPILVYLAGQGSKEAIAT
                     SLFVVGVTSLIGLIPHARAHRVRWRTGLIFGAVSMVGAYGGGRVAEYIPGTVLLIAFAL
                     MMLATAVAMLRKGAGLKKGGHKAAHTEMPVRLVVAEGLVVGAVTGLVGSGGGFLVVPAL
                     ALLGGLPMSVAVGTSLLVIAMKSFSGLAGHLAGVQIDWGLALMVTTAAVVGSLVGSRFA
                     GRIPQDTLRKVFGWFVVVMGVFVLSQQLPAAVWTSPWTWIGAGGVGLTATAVVGRTGTQ
                     ALAGRGRRNDAGERPPTDRAVLTPHTEGEPHAHMSSHEGETR"
     gene            2645..2905
                     /locus_tag="F0345_RS00415"
                     /old_locus_tag="F0345_00435"
     CDS             2645..2905
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007443289.1"
                     /locus_tag="F0345_RS00415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00435"
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="WP_207206552.1"
                     /transl_table=11
                     /translation="MQEDAVTAVLNRLRRAQGQLTGIITMIEDGRDCADVVTQLAAVSR
                     ALDRAGFKIVASGMRQCLKGDGAESSSMTEEELEKLFLALA"
     gene            2966..>3460
                     /locus_tag="F0345_RS00420"
                     /old_locus_tag="F0345_00440"
                     /pseudo=""
     CDS             2966..>3460
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557379.1"
                     /locus_tag="F0345_RS00420"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="F0345_00440"
                     /product="MBL fold metallo-hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTSRVEVLTQGLDNRHYLAGGEHAAVAVDPPRDIDQVLAAARRA
                     DHPRGGEPRPQRPRHRRSGAGPDHRRRLPGTGRRERAVRPGAGVRRRHGDGRGRTAAAG
                     CGHPRPHSAPHHLRAGRAGRSGGRVHRRFAADRHRRPPRPGGPRLTEELAAPSHIPIQR
                     AA"
     misc_feature    complement(3891..3904)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 22.87"
                     /tool="antismash"
     gene            4474..4665
                     /locus_tag="F0345_RS00425"
                     /old_locus_tag="F0345_00445"
     CDS             4474..4665
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F0345_RS00425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F0345_00445"
                     /product="hypothetical protein"
                     /protein_id="WP_185392622.1"
                     /transl_table=11
                     /translation="MDLDGALHKDGLTIGKVIETPPGTGVWMALAKTRAYGSMDEVAKA
                     LPSKDAAIRAALEHSRAY"
     misc_feature    complement(5523..5536)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.28"
                     /tool="antismash"
     gene            5837..6724
                     /locus_tag="F0345_RS00430"
                     /old_locus_tag="F0345_00450"
     CDS             5837..6724
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F0345_RS00430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F0345_00450"
                     /product="hypothetical protein"
                     /protein_id="WP_100457161.1"
                     /transl_table=11
                     /translation="MTENPEDGSMARSAPVMPRDEGEHGSAVTRVATELQEFFGISESL
                     LPCAVVVEPRERRVFAVGLTERITLYRLLKELKIAMEPGIARVNQARSEVARAREDLAG
                     RRRRRWQATEPYGPADRGRIARRLREAAEGMDDDAVRLSHWLSDRLLLARPLTTDERQQ
                     ADALFALLHGRFGVLPLRERRGLLRAVRRAVDKLNSLDDVPGTPPEPCTDADLRVVDSQ
                     IRLSRERLRTREAGLRRALRNIALSPLVLSVTRGLGLEQETTRGLLTWRQCTWPVTVLA
                     APERRRPTISYEWA"
     gene            6721..7230
                     /locus_tag="F0345_RS00435"
                     /old_locus_tag="F0345_00455"
     CDS             6721..7230
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F0345_RS00435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F0345_00455"
                     /product="hypothetical protein"
                     /protein_id="WP_124288375.1"
                     /transl_table=11
                     /translation="MSGRPPAQGRFRALLLDQLADERVTKNSLEQRGIAVIASAGTLVA
                     IVLGFVMLTTGQDAPASGVTVTALHATALIALVAASVAGLCVNLPARVAKVAAGDLENV
                     AVEESWDAHDDESSREEFRILADMLSGLRSVNRRRARTLLAALLAEVLALACMSAATIL
                     PLLTDR"
     misc_feature    7626..7641
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     misc_feature    complement(7914..7929)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.58"
                     /tool="antismash"
     gene            8020..8214
                     /locus_tag="F0345_RS29435"
     CDS             8020..8214
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576126.1"
                     /locus_tag="F0345_RS29435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_115069681.1"
                     /transl_table=11
                     /translation="MAGLVLLGVLALAAGGCACVVWAERGGPRWVRYVATVTLAASELV
                     RRSGKNRRRSLNRSTGDGD"
     gene            8518..9118
                     /locus_tag="F0345_RS00440"
                     /old_locus_tag="F0345_00460"
                     /pseudo=""
     CDS             8518..9118
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="F0345_RS00440"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00460"
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDVHHAYRRRAVLRGVDLRLRAGTLCGIVGENGAGKSTLLKILSG
                     EQSPTRGSVRHSGRLGLLSTARCPQRRADCPAAPDVLPGGVPRGRSAVRAGGHGGAGLL
                     RVRR"
     gene            9115..9984
                     /locus_tag="F0345_RS00445"
                     /old_locus_tag="F0345_00465"
     CDS             9115..9984
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828366.1"
                     /locus_tag="F0345_RS00445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00465"
                     /product="ABC transporter permease"
                     /protein_id="WP_185392624.1"
                     /transl_table=11
                     /translation="MRFRPTRFAVATRFTLLEHSRNRFAMILVIVFVPVWTTLAYLAMP
                     DTPARMRLRATGEALAPHGNELTAISGALNAVTLITGFMMFAATFSGSGFDRRLAMAGY
                     PRAHLVLAKVTALALVSAAVAVYATAIACLTWSPRQPLLLAAALFCAGLTYGALGVGFG
                     ALLRREVEGMFAIVMTSIIDLALQNPVMSSGADNPVVEYLPSYGAMQASTAAGFSTSPV
                     PGHLAIQLTWFTGAALLALLGFRRSTRNCLPSTTLAPPPRPESSKAGLPAPRQAATPSA
                     TAPETKAH"
     gene            10001..11827
                     /gene="uppS"
                     /locus_tag="F0345_RS00450"
                     /old_locus_tag="F0345_00470"
     CDS             10001..11827
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385749.1"
                     /locus_tag="F0345_RS00450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00470"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_181844132.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.4e-27, bitscore:
                     94.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 4.6e-11,
                     bitscore: 40.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRATTKHTTTDLDAALPAQRDRSARRPPTGEDPSLRAAYRLCRRT
                     TRVHDPGIYALIQLMPTVLRPPSWALWAAATALDDLADQPDAKQTERAARVEAWTHALQ
                     RDLAAGASTDPVRHALVDTSLRWHLDLSSLQGAMTSTLDDVRGRHLTDWAAWRSWCNEG
                     IAPWVDQVLHLFERAGVPMTLRLDRQQDYRRFIDGAQLTDTLTDLSADLAQGLLLLPQE
                     ALQTYPRAEEDLRQRRWSPATAALIRELTALAREWLTRPAMTTGMHPGAATVLDTAASL
                     MRAQLDAVDAAGPTLLKHAPHPSLIARARVLAPARLRSSLAWSLTPLALPGPRRPSVTA
                     SDPSLAADDTAFRPPPAHPSGAVPPQIAAEQMPFHVAIIMDGNGRWAQQHGLPRPQGHR
                     AGTAAVHEMVYGALEIGLRHLTLYAFSTENWKRDAEEITTILEAIRRDLDAGPLRDLDV
                     RQRWSGHPDKLPQELVQALMREERRTRTRTGLTLTVCINYGGREEITRTAAALAQAAQA
                     GDIDPHLIGEDDFTRHMPQPDMPNVDLLWRTGNEQRTSNFLPWHATYAELHFTPDYWPD
                     VDRRDLWHALTTYCRRSRRYGNAARVPGPPGS"
     misc_feature    13237..13255
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.47"
                     /tool="antismash"
     misc_feature    13238..13254
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            13308..14183
                     /locus_tag="F0345_RS00455"
                     /old_locus_tag="F0345_00480"
     CDS             13308..14183
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003949286.1"
                     /locus_tag="F0345_RS00455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00480"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_185393707.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-05,
                     bitscore: 23.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLPRLGVVIVTMGTRPHELEALLASVAKQDAPAARVVLVGNATP
                     LTDVATDATKVPLGENLGCPGGRNVGLKLLRESGDVDVAIELDDDGLLIADDVFGQIQQ
                     LFAADPKLGIIGFRVADESGHTERRWVPRLRADDPMRRGQVTAFLGGGHAFSVPMLERI
                     GDWAGEFLFGHEETDLAWRALDDGWKILYEPDLVLQHPKTSPARHAVYYRFTARNRVWL
                     ARRRLPLPLIPVYLGVWIVLTSSRLRSLSGLRAWCGGFVEGLRSPCGSRKAMKWRTVWR
                     MTRLGRPPLV"
     misc_feature    complement(13327..13347)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            complement(14464..15015)
                     /locus_tag="F0345_RS00460"
                     /old_locus_tag="F0345_00485"
     CDS             complement(14464..15015)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891794.1"
                     /locus_tag="F0345_RS00460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00485"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_100457155.1"
                     /transl_table=11
                     /translation="MTELGPVVWPPSSIRTERLVLRQSEAWDRAAFIELFASEEVHAYL
                     GGPRPREELESAVPEVPGRRPGLFVVALNGAMIGTITLLDRRGAERPGHVRPEAGEAEL
                     GYMFLPEAWGRGYAAEACAAALDWFAGTFPGEPVVLCTQTGNNRSMSLAAKLGFTEVQR
                     FEEWGAEQWFGVWSSDAPFG"
     misc_feature    complement(14689..14691)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14981..14990
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(15286..15301)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.89"
                     /tool="antismash"
     gene            15546..16232
                     /locus_tag="F0345_RS00465"
                     /old_locus_tag="F0345_00490"
     CDS             15546..16232
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010645383.1"
                     /locus_tag="F0345_RS00465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00490"
                     /product="hypothetical protein"
                     /protein_id="WP_100457154.1"
                     /transl_table=11
                     /translation="MAKRKVERRARKILGEEPVALVWCEIRPVPAPPKDVHRAAGKGPL
                     KSRHHWLWYVGVVVFCFVIVPIILIDTLGRKFDQLLSGRSRGGQTGQPQSPPDTQRSGR
                     RRSRKGDRGQDPADGVFDGDWDLTAGQLLLRWYGHSPSPKRLVMLTRNRICVAASPRRR
                     LSPTKADDFRTITEFTLDQARIEGEAGQPRGYATFRLVFADGSWLEMGQLGEPEDADHF
                     LRTVSG"
     gene            complement(16413..17396)
                     /locus_tag="F0345_RS00470"
                     /old_locus_tag="F0345_00495"
     CDS             complement(16413..17396)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979323.1"
                     /locus_tag="F0345_RS00470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00495"
                     /product="phosphotransferase family protein"
                     /protein_id="WP_100457153.1"
                     /sec_met_domain="APH (E-value: 4.9e-28, bitscore: 97.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVDEGAEHSSGRADDRGWGATRGWVEKGLSGAERIEDVAPLRGG
                     WTSEMRRLDICGRDGRRSLVLRSFVNPFYVRHAQGLLTREAAVLRLLDGTGVPAARLVA
                     VDATAQHCDHPSLLMSLLPGTVRLGDEGADRRAELLAHQLLRIHRLPVTAEARPREYQA
                     WTSPERVSPPEDTDQPELWQRAVDVIRHEPPEYQACFLHRDFHPGNVLFTGEGGGLRIS
                     GVVDWVETSWGPADLDVAHCSTALALLHGVSAGMDFADRYVAAGGTLAEEPAAHLYWRL
                     LDALAFAPDAEKVAVPWREVGRADLTPALLTRRLEGYLHALCARYT"
     misc_feature    17618..17637
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.35"
                     /tool="antismash"
     misc_feature    complement(17893..17907)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.28"
                     /tool="antismash"
     gene            18194..19117
                     /locus_tag="F0345_RS00475"
                     /old_locus_tag="F0345_00500"
     CDS             18194..19117
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016434880.1"
                     /locus_tag="F0345_RS00475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00500"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_185392626.1"
                     /sec_met_domain="Abi (E-value: 6.3e-15, bitscore: 53.7,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPWGAPPVQWLKRQFSQAPFVSTRRVWPTGVRLAVLVVLFLLVT
                     GLAAGMRSVAGDNPVLSLTFGVAAAVIALAVYAAAVRFLEQRPVSELDTAGAVPTLRRG
                     ALVGLGLFTATLALIALSGGYGTRGGVSVGGAFTVLGMMVGVAVVEEILFRGIVFRLVE
                     QLAGTLGALAVSGVLFGALHLVNSGATVWGALAIAVEAGLMLGAAYAATRTLWLPIGLH
                     LGWNFAVSGVFGVTVSGNQDMPAGLFHSVLSGPAAITGGDFGPEASVFAILVCAVPAVV
                     FLRSAKRRGRLHSRGRLRSEETRTVS"
     gene            complement(19446..20150)
                     /locus_tag="F0345_RS00480"
                     /old_locus_tag="F0345_00505"
     CDS             complement(19446..20150)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133165.1"
                     /locus_tag="F0345_RS00480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00505"
                     /product="response regulator transcription factor"
                     /protein_id="WP_185392628.1"
                     /transl_table=11
                     /translation="MSASATAIRVLICEDQALVRAGFVTILSAQPDMEVVGEVTDGRAA
                     VRSAEELKPDVIVMDIRMPLLDGIEATRHLAGPASRSPARILIVTNFNVDAYVYEALRA
                     GASGFLLKDAAPPELINAVRTVARGEALLAPAVTRALIGRHAERLRPAAAPVPPERERL
                     KALTRREHEVLLLISEGLSNAEIATTLVLSPETVKTYVSRILTKLDLRDRVQAVVLAYR
                     AGLAGSGNGDRA"
     gene            complement(20147..21403)
                     /locus_tag="F0345_RS00485"
                     /old_locus_tag="F0345_00510"
     CDS             complement(20147..21403)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527527.1"
                     /locus_tag="F0345_RS00485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F0345_00510"
                     /product="sensor histidine kinase"
                     /protein_id="WP_258057145.1"
                     /transl_table=11
                     /translation="MRSASSAQEGGLPAHARLPAAANARLRLLVRWWEARPATVKDREF
                     ALVFTVLSFAPPLALIGARFGDLPVHGGSAVSVLLTLGQCLPIAVRTRWPGACLAVVGT
                     SFAVHQCLGCPPTFGSLGLYVALYSVGAHQARFRRTVPLAATGAYVLFGVVLHMLGSPA
                     GVTDYLLFPLVLAAVWGLGALVRWEREREAVRRRLAARVAVAEERDRMARELHDVVTHH
                     VTAMVVQAGAAQYLTASPDRLNSALETINSTGRRALAELRFLLGVLEATGDAEPQGRTP
                     TPGRVADLVEQTRAGGQPVELIEEGEQPAITTGARLAAYRTVQESLTNAVKYAAGRQTL
                     VRLTHTPHWTEVEVITAGTKGGTCRSAAPREDGSHPSGGRGLTGLRERVETLGGAFTAG
                     ARPEGGFRVHARIPAGAGA"
     misc_feature    complement(21146..21148)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21519..21533
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.07"
                     /tool="antismash"
ORIGIN
        1 ctcggtgggc gtgaccgccg acgagctcgg cgcgatgctc cacgacagtg tgcagaacaa
       61 gctgatgagc ttgccagacg atgtgcgcgt cttccccgct cacggtgccg gctcctcctg
      121 cggcaaaaac ctctccaccg agcggcagtc gacgatcggt gagcagcgcg ccaccaacta
      181 cgcatgcgcg ccgatgagcg agaaggactt cgttgccatc gtgaccgccg ggcaatcggc
      241 cgcgccgggc tatttcgcct atgacgcgga cctgaaccgc cgggagcgag agctgttcga
      301 cccggcgagc ccgccgcagg cactgggcgc gcaggacttc ctggcccggc gcgcggcggg
      361 cgccgtcgtg gtcgacgccc gtgacccgca ggagttcgcc gccggccacc tgcgcgaggc
      421 agtcaacgtc cctgccgacg gccgattcgc cgagcaggcc ggtaccgtcc tgccgctcga
      481 ggcggagctg ctggtcgtcg ccccggagga ccgtgaggaa gagatcgtca cccgcctcgc
      541 ccggatcggc ttcgaccggg tggtcggcta cctggcctcc cccgacgagg cgctggaggc
      601 ggtggccgac gaggtcaccc cggccagccg cctgaccgcc gcccagctac gtgccgaact
      661 ggagggcgac aacccgccgg tcgtgatcga cgtccgcaac tgcggcgagc gcggcgagaa
      721 cgggttcatc gagagtgccc tgcacatcgc gctcggcgag ctgccccgcc atcttgacga
      781 gatcccgcgc gacaagccgc tggtcctgca ctgcgccggc ggtcaccgct cctccatcgc
      841 cgccagcctg ttgcgccagc acggcttcga agacgtctcc gacgtgctcg gcggctgggc
      901 cgcctgggcc ctgctgaaca cgcctgccgc cgcctgaccc ggcggaccgc aacaggctgc
      961 cggtgcgccc gcggcaggga actgccgccc tgaccgcccc cggcgcgggc gcatcggccc
     1021 ccaacgttct ttccccgcgt ttcccctgtt ctccgcccgt acctggtacg agtccgcatc
     1081 acccttggag ttttcatgac gaccgccaac gacaccactt tcacccccgc cgctctccag
     1141 cacctgatca agaccggcca ggccccccgc ctactggacg tgcgcacccc tggcgagttc
     1201 cagaccagtc acatccccgg cgcctgcaac gtaccgctgg acaccttgcg cgaacaccgc
     1261 atggagcttg ggcggcacct cgacgagaac gtggtgttgg tctgccgctc cggcgcccgc
     1321 gctacgcagg ccgaggaggc cctcgccgac gcgggcctgc ccaacctacg ggtcctcgac
     1381 ggcggcatga tggcctggga ggcttccggc gccccggcca tccgcggccc gcagcgctgg
     1441 gaactggaac gccaggtccg cctcatcgcc ggctcggtcg tcctcgtcag cggtgtcgtg
     1501 ggcttcttcg tccccggcgt gcacttgatc ggcaccgcaa tcggcgccgg gctgaccttc
     1561 gccgccctca gcaacacctg cgccatgggc atgatgctct ccaagctgcc ctacaaccgg
     1621 ggcccgcgca ccgatatcca caccgtcatc acctccctgc gggaccggtc atgatcaccg
     1681 tcgtcctcgc cgcgtccgtc ctgatcggca tcagcctggg catcctgggc ggcggcggat
     1741 cgatcctgac tgtgccgatc ctggtctacc tggccgggca gggcagcaag gaggccatcg
     1801 ccacctctct gttcgttgtc ggcgtcacca gcctgatcgg cctgatccca cacgcccgcg
     1861 cccaccgggt ccgctggcgc accgggctga tcttcggcgc ggtcagcatg gtcggcgcct
     1921 acggcggcgg acgcgtcgcc gagtacatcc ccggcaccgt cctgttgatc gcgttcgccc
     1981 tcatgatgct ggccaccgcc gtggccatgc tccgcaaggg cgccggcctc aaaaagggcg
     2041 gacacaaggc cgcccacacc gagatgccgg tgaggctcgt agttgccgag ggcttggtgg
     2101 tgggcgcggt caccgggctg gtcggctccg gcggcggctt cctggtcgtc cccgccctgg
     2161 ctctgctcgg cggactgccc atgagtgtcg cggtcggcac ttcgctactg gtcatcgcga
     2221 tgaagtcgtt ctccgggctc gccggtcacc tggccggcgt ccagatcgac tggggcctgg
     2281 cgttgatggt gaccactgcg gcggtcgtcg gcagcctggt cggcagccgc ttcgccggac
     2341 gcatccccca ggacaccctg cgcaaggtat ttggctggtt cgtcgtcgtc atgggcgtct
     2401 tcgtcctcag ccagcagctc cccgccgcag tgtggaccag tccctggacc tggatcggtg
     2461 ccggcggcgt cggcctcaca gcgactgcgg tcgtgggccg gactggcacg caagcactgg
     2521 ctggaagagg ccgacggaac gacgccggag aacgcccacc gactgaccgt gcggtcctga
     2581 caccgcacac agagggggaa ccgcacgctc acatgtcatc acacgaagga gagacccggt
     2641 gaaaatgcag gaagacgcgg tgaccgcagt cctcaaccgg ctgcgccgcg cccagggaca
     2701 gctcacggga atcatcacca tgatcgagga cggccgcgac tgcgcggatg tcgtcaccca
     2761 gctcgccgcc gtctcccgcg ctctcgaccg agccggattc aagatcgtcg ccagcggtat
     2821 gcgccagtgc ctcaaaggcg atggggccga atcctcgtcg atgacggaag aggaactgga
     2881 gaagctgttc ctcgctctgg cgtgaatgcg gacgtgcggt ctcccagacc tgccctcctt
     2941 cggccacagc cggccatcca ccggtttgtc gacaagccgg gtcgaggtac tcacccaggg
     3001 cctcgacaac cgtcactacc tggccggcgg cgagcacgcg gccgtggccg tggacccgcc
     3061 gcgcgacatc gatcaggtcc tggcggcggc ccggcgtgcg gatcacccac gtggtggcga
     3121 gccacgtcca caacgaccac gtcaccggcg atctggagct ggcccggatc acaggcgccg
     3181 cctacctggt accggccgac gcgaacgtgc cgtccgcccg ggtgccggtg tccgacggcg
     3241 acacggtgac ggtcgaggaa ggaccgcagc tgcgggctgt ggccaccccc ggccacattc
     3301 cgcaccacac cacctccgtg ctggccgagc agggcgatcc ggtggccgcg ttcaccggcg
     3361 cttcgctgct gatcgacacc gtcgaccgcc ccgacctggt ggaccccgcc tgaccgagga
     3421 actggccgct cccagccaca tcccgatcca acgagctgca caagcggctc ggcgaggccc
     3481 cggcgggcac cgtgtgggtg cactgcgccg gtggcatgtg cgccgggata gccgcctcgg
     3541 cgggccgtga cgtggtggcc gtcgacgacg gattcgactc cgccaccatc accggaccga
     3601 ccctggaccg actgaggagc ccggacaccc ggagcggcca ccacctcggc ggcctcaaaa
     3661 gccgtgggac cccaatccgg cagtggctgg ccggcaacgg acaagaagaa acaccgtcca
     3721 tgccctgggc tccataaccg actcgggcgc caggccgggg tcggccgcag gcgtggcgcg
     3781 catcggttcg ggcagcgccc aggtcaacgg ggatgccgac tctgccgcac ggtaggtggc
     3841 agtgaggttg agcagccagg gctacgggtt gggggcaggt ggcttcgtac tcgatctggg
     3901 tcaatcggac ctggcgtttc tggccccggc ggcggtggta ggtgcgctca acccgggtga
     3961 cgaccccgtc cgcagctcct gacgggtggc ccaagcaccg cggctgagga cggtattctg
     4021 cgatggcgcg gagaagctct ccatggcagc gttgtcaccg acggcaccga cccggcccat
     4081 cgatccgatc atgctgcgac gtgcgagaac ggcgacgaat ttccgtaagc gaaaccgccc
     4141 gccgcggccg gaacgcgcaa ggcatcctgc gacctgaccg cggcgggcga cggcggattc
     4201 aagggctctg acggccaggc tggagttcat ccgggcgtcc caggtcttgc cgaacacgaa
     4261 gccagggagt tgtactgagc tgcgggctgg tgctcaccaa gaacgggtac gaaagagacc
     4321 atggtctctc accggtgctg tcgctgagcg ccaccggcaa agagcggttt ctgcttcacc
     4381 agcagcaaga agaacctggt cacggagttg aggatcaaga acgccactta tcgaggagta
     4441 cgcatgaggc ggaacctacc aagaggcgta tccatggatc tggacggtgc cctccacaag
     4501 gacggtttga cgatcggcaa ggtcatcgag acgccccctg ggacgggtgt gtggatggct
     4561 ctggcgaaga cgcgtgctta cgggtccatg gacgaagttg ccaaagcgct gccaagcaag
     4621 gacgcggcga tacgcgccgc cctcgagcac agccgagcct attaggcata gccgccgccc
     4681 ccacatgcat cgtccgggtg ccactaccgc tgggcagaac ggcccgtcca ccatccctgt
     4741 ggacgggccg cccactgagc ccccgccgag ctgcgccgct actgagtgga ggaggtcgcc
     4801 gtcagcaggc tgtcgccgtc accctcgtac gtggcgaacc ccccgcgcca tcccgacgta
     4861 cgccctgtgg tcggtggcct ccttgccctt gctgccggcg tggcgccgat gatgccgcgg
     4921 aagtaccggg tcgcggtgag ggactgctcg gtctgggggc accggcccgg acctggacgc
     4981 gttcacagcc gcggcggtcg ccgtaggtac ggttcttggc cttgggccac tcgtcgtcgc
     5041 cccaccggat ctcggcgacc tcatcctcca gccggcgcag cgccgtggtg acggcccgct
     5101 cgtgggcccg cccgctgctc cggcacacgg tggcgtcgcc cagcgcccca cagcacggcc
     5161 ggcgacgcct gcggccggaa ggtggagtcc atgccgagca ccggggtctg gtatgcggac
     5221 ctcgctcccg tcgatcggcc acccacacgg ttggcctgcg ggccgtgacc gcttcgacgc
     5281 cgtcgtcggg aggccgcgct cgatgcggac ggcgtccacg tacctgtccc ccaccgcccg
     5341 tgtggggcgc cggccctcag cgccgcctac gaccaacagc cgacccgccc gaccgttgcc
     5401 gtcgacaccc ctgctcacag tcctgaacgt cacggagcag ttccgctacc aggggcagcc
     5461 cttgggccac ccctggtagc gtcgccggtg tcaagccttc gaccatgagg ggccgaccta
     5521 gattgatggt catcaacgta cccgtcagca ggctgttcgg gctcggactg gcccggtgga
     5581 ggacggcgga ttcgcgggac tcgtcttcct ggtctgccga accgcagatg agcctcgggt
     5641 gcagctggac tttctccgga gttggagtag tttccacgac ctttcgggac gttacctcgc
     5701 tgtcgtcact cccgcgccgg acgcggctct cattgttcaa gggccttcgc gcgaaggtgt
     5761 ggggcaggtg gtccagaatc ttcgactcca tggagacgaa aggaggctgc agagcccttc
     5821 aggaaaccgc gtccgcatga cggagaaccc ggaggacggc tccatggccc gcagtgcacc
     5881 ggtcatgcca cgtgacgaag gagaacacgg gtccgccgtc acccgcgtcg cgacggaact
     5941 ccaggagttc ttcggaatct ccgaatcact cctcccctgc gcggtcgtcg tcgagcccag
     6001 ggaacgccgg gtgttcgcgg tcggattgac cgagcggatc acgttgtaca ggcttctgaa
     6061 agagttgaag atcgcgatgg aacccggcat cgcacgcgtc aatcaagccc ggtccgaagt
     6121 ggcccgggca agggaggatc tagcaggccg gcgacgtcgc aggtggcagg cgaccgagcc
     6181 ctacggtccc gccgatcgcg gcaggatcgc ccggcgactc cgtgaggccg cggaggggat
     6241 ggacgatgac gcggtgcggc tgagccactg gctcagtgac cgcctcctgc tcgctcggcc
     6301 cttgaccacc gacgaacgac agcaagctga cgccttgttc gccctgctgc acggacgctt
     6361 cggcgtattg cctctgcggg agcggcgcgg gcttctcaga gcagtgagac gagcggtcga
     6421 caagctcaac agcctggatg atgtgccggg cacgccccct gagccctgca ccgacgcaga
     6481 cctcagggtg gtcgacagcc agattcgtct gagccgggaa cgtctgcgca cccgggaggc
     6541 cgggctgcgc cgcgctctgc gaaacatcgc gctcagcccc ctcgtgctgt ctgtgacacg
     6601 cggcctcggg ctggaacagg agaccacccg cggcctgctc acctggcggc agtgcacctg
     6661 gcccgtcacc gtgcttgccg cgccggaacg gcgtcgtccc accatcagct acgagtgggc
     6721 atgagcggcc gccctccagc ccagggccgc ttccgggcgc tgctgctcga ccagctcgcg
     6781 gacgaacggg tcacgaagaa ctcgctggaa caacgaggca tcgcggtcat cgccagcgcg
     6841 gggaccctgg tggccatcgt tctgggcttc gtcatgctga ccacgggcca ggacgctccc
     6901 gcatcgggcg taaccgtgac ggcactgcac gccaccgctc tcatcgctct ggtcgccgcc
     6961 tcggtcgccg gactctgcgt caatctgccg gcccgggtcg cgaaggtcgc ggccggggat
     7021 ctggagaatg tggcggtcga agagagttgg gacgcacacg acgacgagag ttcccgcgag
     7081 gagtttcgca tccttgcgga catgttgtcc gggctgagat cggtcaatcg gagacgggcc
     7141 cgaacgctgc tcgctgcgtt gctggccgag gtcctggcac tggcgtgcat gagcgccgcc
     7201 acaatcctgc ctctcctcac ggaccggtag acgtgcgtca accgattgct cagtgacggc
     7261 tcgctgacct gccggagcat ccttcctccc tgccacggag ccgtcctgcc ggccggggtc
     7321 gagaggccgg agccttgcac gcgttcggct cgttgatgcg gacctggctg gtgtcagcct
     7381 gtccggggcg gcgctgcact cggtgggtct tgcgtttgcg cagcacggcg tcaatctgca
     7441 agacgttgaa ctcccggggg cgtgctcgtc cggtgcgacg tcgcagaatg tcgacacacg
     7501 gggcgaacct gcgaggagcg gatctgcgcg gcggggatca tcgggtactg agtactgatc
     7561 cgttctcacc gataccgcct ctcgaccatg tgatcacccg gcccgggggc atccggccgc
     7621 gtcacgtatg cacatgtcaa gaatggcgag gtagatcgcg gcgtggccgg ccggtagagg
     7681 gcagccgggt cctcggggac ctgagcggca tcgctgctcg acctgccgcc gctcttcggc
     7741 ctcccgccgg ccgcagacgt ccaggccgtc cacacacagc tgacctgcag ctgttcagga
     7801 tgaaagaggc tcaatgggga gcggtaccgt ggcacggagc ccggtagcac ttcactccga
     7861 tgaatgatct tgttcgttcg ccaggagatt gcgacgacca ggagttccgg ccacctggtc
     7921 tcgaccgatg atcttctgcg agccagggcg tcccgttgca accgccccgg cctgagacga
     7981 tcagcaggac ccgtacgaat gaatgcagag gtggggaaca tggccggtct cgtactgctc
     8041 ggtgtcttgg cgctcgcagc tggcgggtgt gcgtgcgtgg tgtgggcgga gcgcggcggg
     8101 ccccgctggg tccgctacgt ggcgaccgtg acactcgccg cgagcgagtt ggtgcgtcgg
     8161 tccgggaaga accggcgccg gagcctgaac cggtccaccg gcgacggtga ttaggcagtt
     8221 tcgtttggac cgtcgggtgg gccagaggaa gatgcccgcg ctgcggggcc accccgcttc
     8281 ggcgtccggt ccgggcaacc gctcgatccg cgcccactgc gcatcactcg acgccacgcc
     8341 cggaccaccg accgactgat ccagagaaac tgcctggtgg cgggcaaggg cggccggcca
     8401 agtgagcgcc gccacacacc tccagcttgg gtggcgtgcc ctttccgcgt cgctgaccgt
     8461 taggccgttc gtcacggtca gtccacgttt acgggggaaa agacggacgt ggaggtcatg
     8521 gatgtgcacc atgcctatcg gcggcgtgcg gtcttgcgag gtgttgatct acggcttcgc
     8581 gccgggacgc tgtgcggaat cgtcggggag aacggcgccg gcaagtccac gctgctgaag
     8641 atcctgtccg gcgaacagag ccccacgcgc ggctcggtcc gccacagcgg ccgactcgga
     8701 ctactgtcca cagcgcgttg tcctcaacga cgcgctgact gtccggcagc acctgatgtt
     8761 cttccaggcg gcgtaccgcg tggccgatct gcggtacgcg caggaggtca tggaggtgct
     8821 gggcttctcc gggtacgccg atgagcgtgc cggggtgctc agcggtggca cgcgacagaa
     8881 gctgaacgtg acgctggcgc tcatgcacga tccgcaggta ctccttctgg acgagccgta
     8941 tcaggggttc gactgggaca cgtaccagcg gttctgggaa ctggccgggc agctgcggga
     9001 cgcgggacgt tcagtcctgg tcgtctctca cctggcgtac gacacagagc gtctggacga
     9061 gctgtggcgc ctggacagcg gcgtactgtg cgccggtgca gcgggggtga ccgcatgagg
     9121 ttccgcccga cccgcttcgc tgtcgccacc cggttcacgc tcctcgagca cagccgcaac
     9181 cgtttcgcca tgatcctggt gatcgttttc gtcccggtgt ggacgaccct ggcgtacctg
     9241 gcgatgccag acacccccgc gcggatgcgg ctacgcgcca ccggggaggc gctggccccg
     9301 catggtaatg aactgaccgc gatcagcggg gcgttgaacg cggtcacgtt gatcaccggt
     9361 ttcatgatgt tcgccgccac attctctggc agcggcttcg accgtcggct ggccatggcc
     9421 ggctaccccc gtgcccatct ggtcctggcc aaagtcaccg ccctggctct ggtctcggcg
     9481 gcggtcgccg tgtatgccac ggccatcgcc tgcctgacct ggtcaccccg ccagcctctc
     9541 ctgctcgccg ccgccttgtt ctgcgccgga ctgacctacg gcgccctcgg ggtcggcttc
     9601 ggggcgctgc tgcgacggga ggtggaaggg atgttcgcca tcgtgatgac cagcatcatc
     9661 gacttggcgc tgcagaatcc agtgatgagt tccggagctg acaatccggt cgtggagtac
     9721 ctgccttcgt atggggccat gcaggccagt acggcggccg gattctccac cagcccggtc
     9781 cccgggcatc tggccatcca gctcacctgg ttcaccggtg ccgctcttct cgccctactg
     9841 ggcttccgtc gcagcacccg caactgcctg ccgtccacca ccctcgcccc accgcccagg
     9901 ccggaaagca gcaaggccgg tcttcccgcg ccgcgccaag ctgccacgcc atcggcgacg
     9961 gcgcctgaga cgaaagcaca ctgaggtccc ggcccccgac atgcgcgcca ctacgaagca
    10021 caccacgaca gacctcgatg ccgccctgcc cgcccaacga gaccggtccg cccgccgccc
    10081 gccaaccggc gaagacccgt ccctgcgggc cgcgtaccgg ctgtgccggc gcaccacacg
    10141 tgtgcacgat cccgggatct acgccctcat ccagctgatg cccaccgtgc tgcgcccgcc
    10201 gtcctgggca ctgtgggcag cagcgaccgc cctcgacgac ctcgccgacc agccggacgc
    10261 gaagcagacc gaacgcgcgg cacgcgtcga agcgtggact cacgccctgc aacgcgacct
    10321 ggcggcgggc gccagcaccg atccggtccg ccacgctctg gtcgacacct ccctgcgatg
    10381 gcatctggac ctgtccagct tgcaaggcgc catgaccagc acactcgacg acgtccgggg
    10441 ccggcacctc accgactggg ccgcgtggcg gtcctggtgc aacgagggca tcgcaccctg
    10501 ggtggaccaa gtgctgcacc tgttcgagcg agccggagtg ccgatgacgc tccggctgga
    10561 ccggcaacag gattacaggc ggttcatcga cggcgcgcag ctcaccgaca ccctcaccga
    10621 cctgagcgcc gatctcgccc agggactcct gctcctgccg caagaggccc tgcagactta
    10681 ccccagggcg gaagaagacc tgcggcagag acgctggagc ccggccacag cagctctgat
    10741 ccgggagctg acggccctgg cccgcgagtg gctgacccgg cccgcgatga caacaggtat
    10801 gcacccaggc gccgccaccg tgctcgacac ggccgcctcc ctgatgcgcg cccagctcga
    10861 cgccgtcgac gcggccggcc ctaccttgct caagcacgct ccgcacccct ccctcatcgc
    10921 ccgcgcccgc gtcctcgccc ctgcccgcct ccgctcgagc ctggcgtgga gcctgacgcc
    10981 tctggccttg cccggccccc gacgcccctc ggtcaccgcg agcgatccga gtctggcagc
    11041 cgacgacacc gccttccgcc ccccgccggc acacccgagc ggtgccgtac ccccgcagat
    11101 cgccgccgag cagatgccct tccacgtggc gatcatcatg gacggcaacg gccgctgggc
    11161 ccagcagcac ggcctgcccc gcccgcaggg ccaccgcgcc ggcaccgccg ccgtccacga
    11221 gatggtctac ggcgccctgg agatcggcct gcgccacctg accctctacg cgttctccac
    11281 cgagaactgg aaacgcgacg ctgaggaaat caccaccatc ctggaagcga tccggcgcga
    11341 cctcgacgcc ggtcctctcc gcgacctcga cgtacgccaa cgctggtcgg gccaccccga
    11401 caagctgccc caggaactcg tccaggccct catgcgcgag gaacgccgca ctcggacccg
    11461 caccggcctg accctgaccg tgtgcatcaa ctacggcggc cgtgaagaga tcaccaggac
    11521 cgcagcagcg ctcgcccagg cagcccaggc aggcgacatc gacccccacc tcatcggcga
    11581 ggacgacttc acccgccaca tgccccaacc cgacatgccg aacgtcgacc tactgtggcg
    11641 caccggcaac gaacagcgca cctccaactt ccttccctgg cacgccacct acgccgagtt
    11701 gcacttcacc cccgactact ggcccgacgt cgaccggcga gacctgtggc acgccctcac
    11761 gacctactgc cgacgcagcc gccgttacgg caacgccgcg cgggtccctg ggcctccggg
    11821 ttcctgaacg tctggccgta ggaactccgg gggctactgg accccctgcc cctccggacg
    11881 agtcgaagac tgtcactcgc ttcgtcgggg atgcttcgtg gcacgttcgg aggggaccac
    11941 cgtgatgtgc cacacggtgg ccggagcgga ggcgccgcgc aggcgcatca ggtgaagcgg
    12001 atcgtccgcc tcggacgcct cgtcgcgagc tggtccttcc gcagcatcgg ccgagcgaag
    12061 cggggatgcc gggcggatcg tccaggcggg gccgcgcgct ggtggcgcgg ggccgcgggc
    12121 gcggatgggc gcccctgggc tcccttgcgg cgctgcgcct gcgccccggc cgtcgaggac
    12181 acgaccggcg cccgggtccg gcttgtcccg ttgctccgtt gctccgttgc tccgtgactg
    12241 cctgccgtcc tggggatgcg aggcacgcga tgcaaggtgt cttctcgggc catcctccct
    12301 ggcttcacct ctgaagccac ctcctgcacg ccgcctccga cctgttcggg cgccgcttcc
    12361 tgggcctccc cgaagtcgca tccccgtacg ggcgcgcctc acacggctcg tctgcctgcg
    12421 cgggcggagg catataacgc ctgagccgca ggaggcgatc ttcgagatgt caggggccga
    12481 gtgcggatca gattcccgac ccgcactcgg cccgccatct ccaggcttcg caacggcagt
    12541 ctccagctcg cgggcacgcg tccgccgggc ccagaactcg gctgcttccc ggcggggacg
    12601 gctccttcga cgtgctgcgc gaagcacgaa cgcgggggcg ggctctgggc cacgccgcgg
    12661 ttgccgcgtt cgttctgcga gccatcgacg accggcagcg cgtccgcgct cccataacgc
    12721 tcgacggtgc tcaggctgac caacccaggg cctgcgccga ggcaggcctc gtttgtgaac
    12781 gccggtaccg accgtgccgc acacgggaat gcgcggtacg agccgaagag gctggagtga
    12841 cggcatcggg ttctgcagcg gcgcagccgg cgggacgggt cgaggtgggc ctcccgctcg
    12901 ccggaccggt cttgcggcct ggcagcgtct cgcgtctgga cgccgtcgaa ggactcggcg
    12961 cgtgcgttgt ccgcgccgga gccgaccgtg ctcatggctg gccggacgcg ggctttgtgg
    13021 caggcgtcgg cgaaggcccc gctggtgtac ggggctccgt ggtcggtgtg cagggccgct
    13081 ccggcgaggc cgccgcggac gcgttcaggg acggtcagag catcgatgct gtcacaaacc
    13141 gaccgctgct cctcgtgccg cccttgcagg tcagcatggt cataaccgga gaaggggaac
    13201 aggagactgg ccgactccat tccgcgatgt caagggcttg cgtgcgactc gcagtagagg
    13261 agggccacta gcatcagcgt gtccgccgac acatggagtt tgccgttatg ccgttgccgc
    13321 gtctcggagt cgtcattgtg acgatgggca ctcgcccgca tgagctcgag gctctcctgg
    13381 cctccgtggc gaagcaggat gctccggcag cgcgggtggt gctggtgggg aacgcgacgc
    13441 cgctcacgga cgtcgcgacg gacgcgacca aggtgccgct tggggagaac ctgggctgcc
    13501 ccggtggccg caacgtcggg ctgaagctgc tgcgcgagtc cggcgacgtc gacgtcgcca
    13561 tcgagctgga tgacgacggg ctcctcatcg ccgatgacgt gttcggccag atccagcagc
    13621 tgttcgcggc agaccccaag ctcgggatca tcggcttccg ggtcgcggac gagagcggac
    13681 acacagagcg acgctgggtg ccgcgccttc gcgccgacga tccgatgcgc cggggccagg
    13741 tgaccgcttt cctcggaggt ggccatgcct tctctgtccc gatgctggaa cggatcggcg
    13801 actgggccgg cgagttcctc ttcgggcatg aagagaccga cttggcatgg cgtgctctgg
    13861 acgacggctg gaagatcctt tatgagcccg accttgttct tcagcacccc aagacctccc
    13921 cggccagaca tgcggtctac taccgcttca ccgcgcgaaa ccgagtctgg cttgcccggc
    13981 gccggctccc cctccccttg atcccggtct atctgggcgt gtggatcgtg ctcactagct
    14041 ctcgcctccg gtccctcagc gggctgagag cgtggtgcgg cggcttcgtg gaggggctcc
    14101 ggagtccgtg cggttcccgc aaggcaatga agtggcgcac ggtgtggcgg atgacgcgcc
    14161 tggggcgccc cccactggtc tgagcatggg gacggagtcc gcaggcgacg atcaggaacc
    14221 agggagcacg ggtccacctg ttggtcttgg ggcaggtttc gagtatctcc tggaggtgct
    14281 ggacggacca gaacctcggt cgggcaggtt cctgacgtga cagggcaggc cgtgccggac
    14341 tcccgctcgt tcactgtcgg gaactcgaag ggatcggcct tcgacccgtg agaccgtgcc
    14401 ctacatggtg ggggcggtca gacagatctg acaggtcacc gcgccttcgc gacaggctcg
    14461 agctcaaccg aagggtgcgt ctgaggacca cacgccgaac cactgctccg caccccactc
    14521 ctcgaaccgc tgcacttctg tgaaccccag cttcgccgcg aggctcatcg agcggttgtt
    14581 gccggtctgc gtgcagagca ccaccggctc gccggggaac gttccggcga accagtcgag
    14641 tgctgctgcg catgcctcgg cggcgtaccc gcgtccccac gcttccggta agaacatata
    14701 gccgagttcg gcctccccgg cctctggacg gacgtgcccc ggacgctccg caccgcgccg
    14761 gtcaagaagc gtgatcgtgc cgatcatcgc cccgttgaga gcgaccacga agagaccagg
    14821 acgtcgccca ggcacctcgg gcaccgcgct ttcgagctct tcacgcggac gaggaccacc
    14881 gaggtaggcg tgtacctctt ccgaggcgaa gagctcgatg aacgccgcac ggtcccaggc
    14941 ctcggactgg cggagcacga gccgttcggt ccgtatcgaa gaaggcggcc agacgacggg
    15001 gccgagctca gtcatggcgg gcaacctatc gctccctgcg agagtgctcc aaaggaacaa
    15061 ctcgcggagt ccggctcccg gcgggtctct ggatcggaga accgcacgaa acggcccagc
    15121 gcatggatcc ggcgttccgg cgcaacggct tccttccctt gtccagcgca acggcttccc
    15181 tttcctctcg cgtcggaaga ctcggctgtg ctgtgagagg gcggtacgcg aggtggtccg
    15241 ttccgcaatg agcatggggc caggtcgccg gtcatggtct cgacggctac tgattctcgt
    15301 ggcgccgccg gcgtcgacgt cggtgaggac agcgagcttg gcgaagggtt tcagttcggc
    15361 gcgggtgcct tcgatgtact cggcagcagt gcgcggccaa gggcttggcg gacgtctcgg
    15421 gccggagggg ccggcggctt cgttgcagac ggccggcacg cgggagcggt ccgggtgctc
    15481 gggcagctcc ctccgcgtca agacctctct acgggcttcc acaggccggc actaggatct
    15541 tcggcatggc gaagcgcaag gtggagcgac gggcgcggaa gatcctgggc gaggaacccg
    15601 tggccttggt ctggtgtgag atccgccccg tccccgcacc acccaaggac gtgcaccgcg
    15661 cagcgggcaa aggacccctg aagtcgcgcc accattggtt gtggtacgtc ggggtcgtgg
    15721 tgttctgctt cgtgatcgta ccgatcatcc tgatcgacac actcggtcgc aagttcgacc
    15781 aactgctgtc gggacggagc cgtggcggtc agaccggaca gccgcagtcc ccacccgaca
    15841 cacagcgctc cggccgtcgc cgctctcgca agggggaccg cgggcaggac ccggccgacg
    15901 gagtcttcga cggggactgg gacctgaccg cgggccagct gctgctgcgt tggtacgggc
    15961 actcgcccag tcccaagcgc ctggtgatgc tgacccgcaa ccgtatctgc gtggccgcgt
    16021 cccctcgccg tcggctgtcg ccgaccaagg ccgacgactt ccggaccatc acggagttca
    16081 ccctcgacca agccaggatc gagggtgagg cgggccagcc tcgcgggtac gccaccttcc
    16141 ggctcgtctt tgccgacggt tcctggctgg agatgggcca actgggcgag ccggaagacg
    16201 ccgatcactt tctgcgtacg gtcagcggct gatcggctcc tcacgctgcc acggccgctc
    16261 aggcctcttc tccctcgaag tccccatccc cgtcggcgac cgaacggacc ctggtcgagc
    16321 cccgtcgtcc tgctggatgc cccagtacga accacgcgca accggacggt ccccagccag
    16381 ggcggtcctg ctcgcccgcc gtcggtccgg cttcaggtgt agcgcgcgca gagggcgtgg
    16441 aggtatccct ccagccgcct ggtcaacagg gcgggagtca gatcggcgcg gcccacctcg
    16501 cgccacggga cggcgacctt ctcggcgtcc ggagcgaagg ccaaggcgtc cagcagccgc
    16561 cagtagagat gggcggcggg ctcttcggcc agcgtccctc ccgccgcaac gtagcggtcg
    16621 gcgaagtcca tgcccgcgga aaccccgtgc agcagggcca gggccgtcga gcagtgggcc
    16681 acgtccaggt cagcgggccc ccaggaagtc tccacccagt cgacgacacc gctgatccgc
    16741 agaccgccgc cctcaccggt gaagaggacg ttgccgggat ggaagtcccg gtgcagaaag
    16801 catgcctggt attccggggg ctcgtggcgg atcacgtcca cggcccgctg ccacagctca
    16861 ggctgatcgg tgtcctccgg cggactcacc cgctcgggag aggtccacgc ctgatattcg
    16921 cgcggccgcg cctcggcggt caccggcaac cggtggatgc gcagcaactg gtgggccagc
    16981 agttcagcac gccggtcggc cccctcatcg cccaggcgca cggtcccggg caacagggac
    17041 atcagcaagg acggatggtc gcagtgctgc gctgtcgcgt ccacggccac cagcctggcc
    17101 gcgggcacgc ccgtgccgtc gagcagacgc agaacggctg cctcgcgagt cagcaggccc
    17161 tgcgcgtggc gaacgtagaa gggattgacg aaggaccgca agaccagcga ccgtcgaccg
    17221 tcccgcccac agatgtccag ccgccgcatc tccgacgtcc agcctccgcg caacggcgcg
    17281 acatcctcaa tccgttccgc cccggacagt cccttctcca cccagccccg tgtcgcgccc
    17341 cacccccggt catcagcacg accactgctg tgctcggccc cctcgtccac agccatggat
    17401 acaggctacc gaccccgtcg atggaggcgt gtggctccca ttcacaactc ctgaccacta
    17461 ctcgccgcac acgacagcca cgaatcggtt cggagggcgc ccgtgccgct tctgttccaa
    17521 cggcagaacg gacccgtgcc ttacaggccg gtcatgacta cgtcgctgtt ctcgccgaga
    17581 gacgtggtac gcgatcacca ggccgacacc catcagcgcg gggaggtccg gcccgcggtg
    17641 ggtaccagga aacgacctgg cggcgcgggc cgaggccgag gagcatgccg accgccgagc
    17701 agagttcggg tcccgcggac gacgccacgg aacgccttcc ccgcagcctc ccggcaggca
    17761 ggaagccgct ctctcacggt cgggccgtcg ccgaactccc tccacgcctt cggcgccgcc
    17821 catggttgtc gctccccggc gaccgccacc agcagcaggt tctccggagg cacccggggg
    17881 agcactcgtg agccacacgt gtggtggccg gctgcggcgc cgaggacgac ctcatgggtg
    17941 ggctggcgct ccttcctctg agccttctgg acctcagtct ccaggtgttc gcgctccggg
    18001 aaacctcacc gcctcatcgg gtgcccgggc acgacgtccc tcgcgtcgac agccgctgcc
    18061 ggcccgggcc gttgtccccc gtgcgagcta cccgcgacga ccactgcggg gggacgtttc
    18121 ggggtggggg tcgcgcctag cgttgtcccg gtcgaggggg cgtcttggcc tccagtccag
    18181 aaggagaggc atcatgtcgc cgtggggtgc accgccggtg cagtggttga agcgtcagtt
    18241 ctcgcaggca ccgttcgtgt cgacgcgtcg cgtgtggccg accggggtgc ggctggcggt
    18301 gctggtcgtg ctgttcctcc tggtgacagg gctcgccgcg gggatgcgga gcgtggcggg
    18361 cgacaatccg gtgctgtccc tgacgttcgg ggtggcggca gcggtgatcg cgctggcggt
    18421 ctacgcggcg gcggttcggt tcctcgaaca gcgccccgtg tccgaactgg acaccgccgg
    18481 tgccgtgccc accctgcggc ggggtgccct cgtcgggctc gggctcttca ccgccacgct
    18541 cgcgctgatc gctctgtccg gcggctacgg cacccgaggc ggagtgtccg tcggtggcgc
    18601 cttcaccgtt ctggggatga tggtgggcgt cgcggtcgtg gaggagatcc tcttccgcgg
    18661 catcgtcttc cgtctcgtcg aacagctcgc cggcacgctg ggcgcgctgg cggtctccgg
    18721 ggtgctgttc ggagcgctgc acctggtgaa ctccggcgcc acggtgtggg gagcgctggc
    18781 catcgcggtc gaggcgggcc tgatgctcgg cgcggcctac gcggccaccc gcactctgtg
    18841 gctgccgatc ggtctccacc tgggctggaa cttcgccgtg agcggtgtct tcggcgtcac
    18901 ggtctccggc aaccaggaca tgcccgccgg gctgttccac agcgtgctgt cgggacccgc
    18961 cgcgatcacc ggaggcgact tcgggccgga ggccagcgtc ttcgcgatcc tcgtctgcgc
    19021 ggtccccgcg gtcgtgttcc tgcgctcggc aaagcgccgg gggcgcctcc actcccgtgg
    19081 ccgactccgg tccgaggaga cgcgcacggt gtcctgaccc gccgcgacgg gccgcggcca
    19141 gcggaccgac gtgactcacg ggtgtaccgg gaagcggcgg cacgccggcc ccgccgcctt
    19201 cgagggcgcg tcgtcgtggt cgtgggctcc gcggaagact catgccgtcg ccgaggggcg
    19261 gacacgcgcc accacctcgc cgtcttcacg cgactgcgcg aacccctggg gtcggctcgc
    19321 ttgtcggcca acgggtgtac cgcgtgcggc cggtgcgtcg ggctccggcc aagactgctg
    19381 cccctctccc gtgaagcacg gagcacggtc aggctcgcgg cccggtgcac aggatcccgg
    19441 accgctcatg cccggtcccc gttcccgctc cccgccaggc cggcccggta ggccaggacc
    19501 accgcctgga cgcggtcgcg caggtccagc ttggtgagga tgcgggagac ataggtcttc
    19561 acggtctcgg gactgaggac cagggtggtg gcgatctcgg cgttcgacag gccctcactg
    19621 atcaggagga ggacctcgtg ttcgcgtcgg gtgagggcct tcaggcgctc gcgctcgggc
    19681 ggcacggggg cggcggcggg gcgcagacgc tcggcgtggc ggccgatcag cgcgcgggtc
    19741 acggcgggtg ccaggagggc ctcgccgcgg gcgacggtgc gtaccgcgtt gatgagctcg
    19801 ggcggtgcgg cgtccttcag caggaagccg ctggcgccgg cgcgcagggc ctcgtacacg
    19861 tacgcgtcga cgttgaagtt ggtgacgatc aggattctcg cggggctgcg ggaggcgggg
    19921 ccggcgaggt ggcgtgtggc ctcgatgccg tcgagcaggg gcatgcggat gtccatgacg
    19981 atgacgtccg gcttcagctc ctcggcgctg cggacggctg cccggccgtc ggtgacctcc
    20041 ccgacgacct ccatgtcggg ctgtgcggac aggatcgtga cgaagccggc gcgcacgaga
    20101 gcctggtcct cgcagatcaa caccctgatc gcggtggcgg aagcactcat gcgccagccc
    20161 ctgcgggtat gcgcgcgtgc acgcggaagc cgccttcggg gcgagcgcct gccgtgaacg
    20221 cgccgcccag cgtctccacc cgttccctca ggccggtcag gccccgtcct cccgaggggt
    20281 gagagccgtc ctcacgcggg gcggcgctcc ggcaagtgcc gcccttcgtc ccggcggtga
    20341 tgacctcgac ctccgtccag tggggggtgt gcgtgaggcg taccagcgtc tgtcgacccg
    20401 cggcgtactt cacggcgttc gtgagggatt cctgcacggt gcggtaggcc gcgagccggg
    20461 cacccgtggt tatggcgggc tgttccccct cctcgatcag ttcgacgggc tgaccacccg
    20521 cgcgcgtctg ctccaccaga tcggccactc gtccaggcgt gggcgtccgt ccctgaggtt
    20581 ccgcgtcccc ggtcgcctcc agcacgccca ggaggaaccg gagttccgcg agcgcccgac
    20641 ggccggtgct gttgatggtc tccagagcgc tgttgagccg gtccggggag gcggtgaggt
    20701 actgggccgc gccggcctgc accaccatcg ccgtcacatg gtgcgtcacc acgtcgtgca
    20761 attcccgggc catgcggtcg cgttcctcgg ctacggccac ccgagcagcc agccgcctgc
    20821 gcacggcctc gcgctctcgt tcccagcgca ccagggcacc cagtccccac accgccgcca
    20881 ggaccagggg gaagagcagg tagtcggtca caccggcggg cgagcccagc atgtgcagga
    20941 cgacgccgaa gagcacgtag gcgcccgtcg cggccagggg cacggtccgc cggaaacgcg
    21001 cctggtgggc accgacggag tacagcgcga cgtacagccc gaggctgccg aaggtcgggg
    21061 ggcaaccgag gcactggtga accgcgaagg acgtacccac cacggcgagg caggcgcccg
    21121 gccaccgcgt ccgcacagcg atgggtaagc actggccgag tgtcagcagc acgctcacgg
    21181 cggaaccacc gtgcacgggg aggtcaccga agcgtgctcc gatcagcgcc agagggggcg
    21241 cgaacgacag caccgtgaag acgagcgcga actcccggtc cttgaccgtg gcaggacgcg
    21301 cctcccacca ccgcaccagg aggcgcagtc gggcgttcgc ggcggccggc agcctcgcgt
    21361 gtgcggggag acccccctcc tgcgccgagg aggcggaccg cactcctgga gagaacgcca
    21421 cgggcccgtc gggcaccggc ccgcccgagc gggaagcggt gtcgggcctg gccgatggcg
    21481 ccgggaccga tggatcacgc actgcctggt cctccgtcat caccctgatc gatcacttcc
    21541 agtgctgaac agtacgcggc acgggtggcg gcgaaggggc ccgggacgcc ccaccccggt
    21601 gcgatccgtc cggcgagtcg caccacacgg catcacgtgg ccgggcggaa gcccggcccg
    21661 ctcccgcggg gaacagagcc cgcggctctt ccggggccgc tggggacgcg gcagccgccc
    21721 ggctccggcg cggacggtac gtggtgccgc ccgcccggat cgtcccggtg ccgaaggccg
    21781 cgatcgcccc tggcggtcgc ccggacgatg cccgtaccgg ctccggt
//
