LOCUS       NZ_JACHJQ010000005     22016 bp    DNA     linear   CON 27-SEP-2024
DEFINITION  Actinophytocola algeriensis strain CECT 8960 Ga0436956_05, whole
            genome shotgun sequence.
ACCESSION   NZ_JACHJQ010000005
VERSION     NZ_JACHJQ010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinophytocola algeriensis
  ORGANISM  Actinophytocola algeriensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae.
REFERENCE   1  (bases 1 to 962325)
  AUTHORS   Whitman,W.
  TITLE     Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the
            genomes of soil and plant-associated and newly described type
            strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 962325)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 154.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014203735.1-RS_2024_09_27
            Annotation Date                   :: 09/27/2024 05:42:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,095
            CDSs (total)                      :: 9,030
            Genes (coding)                    :: 8,881
            CDSs (with protein)               :: 8,881
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 23S)
            partial rRNAs                     :: 2, 2 (5S, 16S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 44 of 149
            Pseudo Genes (incomplete)         :: 120 of 149
            Pseudo Genes (internal stop)      :: 3 of 149
            Pseudo Genes (multiple problems)  :: 17 of 149
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:06:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 643867
            Orig. end                         :: 665883
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACHJQ010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22016
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="3"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22016
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22016
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12016](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12016
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(682..696)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.35"
                     /tool="antismash"
     gene            complement(748..2334)
                     /locus_tag="FHR82_RS25575"
                     /old_locus_tag="FHR82_005206"
     CDS             complement(748..2334)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.5"
                     /locus_tag="FHR82_RS25575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005206"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_184813022.1"
                     /transl_table=11
                     /translation="MTGTEYPEVPVLVVGGGSVGLLTAALLTHHGVPAVLVERRSGPSV
                     HPRATGIGPRTVEVLRELGLDTAVDAAAVDLRGAAGKAVARTVVEMGAGDVVTVPMPAP
                     AADELDVTPFRLRGVCAQDRLDAVVAADLARRGADLRWSTRLAGITQDTGGVDVELEGP
                     DGRYSLRCAHVVAADGTHSTVRTALGVGTSGPGDLGKSMINILFRADLRPHLRGMSFAT
                     CTITTPAAPGLLATVDGETNWVFHVACDVDAGECPEDFTPERCAAIVRAAVGDPDLDVE
                     VRSVLPWRPRSAAAESFAVGRVFLVGDAAHTVSPLGAFGLNTGVADAHNLTWKLAAVHR
                     GEAGAGLLDTYAHEREPVAAATLDQAMRRLADPELHWGRGPEADAARVAAGVWAAPVVH
                     LGQRYDSAAVVGPRPALPSTMDLSVALDGSPGSRVPHAWIDGVSTLDLVASRWTLLVGA
                     EGEHWLTAAAVTGLPAHRVAVPWLPAEGALLVRPDGIVATRTTTPAPDPARFLTEVLDQ
                     VLARPVPVPSP"
     gene            2390..3094
                     /locus_tag="FHR82_RS25580"
                     /old_locus_tag="FHR82_005207"
     CDS             2390..3094
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671041.1"
                     /locus_tag="FHR82_RS25580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005207"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_221464236.1"
                     /transl_table=11
                     /translation="MTEPVPSSVWTRPRPEPRRRAPGVDQYVAAAMAVADAEGLAAVSM
                     RRVAGDLGSGTASLYRYITNRDELVDLMIDAAQGEDPLPESAGDWRADLGAVAHALRAT
                     LLRHPWLAGELAGRPALGPNSLRRSESALRAAVALTPDITLASRALGAVHAYVLGSVAA
                     QQALLRAEQRTGLTEEEWQRSVGPYISEVLAAGEHPMLARRVLEAEEPDPDVDFAFGLD
                     CVLDGLAARLGR"
     gene            complement(3099..4055)
                     /locus_tag="FHR82_RS25585"
                     /old_locus_tag="FHR82_005208"
     CDS             complement(3099..4055)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015801445.1"
                     /locus_tag="FHR82_RS25585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005208"
                     /product="nucleoside hydrolase"
                     /protein_id="WP_184813023.1"
                     /transl_table=11
                     /translation="MRIILDTDPGVDDALAIMYLAAQEDAEIVAVGSVHGNVSAPLAAR
                     NALRVMELCGLTAPVAVGAARPLAQPLQTAEFVHGVDGLGGHAGPEPSGTVVSESAAEQ
                     LVRLARAHPGELTLLALGPLTNIALAVLLEPDLPKLLRSVVVMGGAVTVPGNITPYADA
                     NFFHDPEAADLVLGAGFPDMTLVGLDATEQARAGGEWLTAVGALDSPRAVFANRLLDHY
                     AGFYSQMFGTHTCTLHDPLAAALLLEPKLATYREMPLAIELSGTHTRGQVVSDQRLIAS
                     DAYIATTAGAGRVPVKVAETVDVPRFLEHMFEALKAH"
     misc_feature    complement(3633..3635)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(3645..3647)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4041..4056)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.44"
                     /tool="antismash"
     gene            4135..4695
                     /locus_tag="FHR82_RS25590"
                     /old_locus_tag="FHR82_005209"
     CDS             4135..4695
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009691 - cytokinin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lysine_decarbox"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331430.1"
                     /locus_tag="FHR82_RS25590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005209"
                     /product="TIGR00730 family Rossman fold protein"
                     /protein_id="WP_184813024.1"
                     /sec_met_domain="Lysine_decarbox (E-value: 2.8e-43,
                     bitscore: 143.1, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVFCGSSPGKGPAYQAAAKRVGEVFAERGIELVYGGASVGTM
                     GVVADTVLEHGGKVHGVIPQSLVDREVAHPGLTTLKVVADLHERKAAMSELADGYLTLP
                     GGAGTLEELFEVFTWAQLGLHDKPIALLDVGGYYQPMLRFLENMSAEGFLADDFRGMLI
                     VTTEVTEALDRFVDYRPPRTKWT"
     gene            4898..5671
                     /locus_tag="FHR82_RS25595"
                     /old_locus_tag="FHR82_005210"
     CDS             4898..5671
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR00254.1"
                     /locus_tag="FHR82_RS25595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005210"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_184813025.1"
                     /transl_table=11
                     /translation="MHTARAGTGGGADHADHSDRHEHVDIVAPRSGDRPLQSVTAAAHH
                     RRCDSCGQLLTDPPTGLIERWHWDEVAAETVAQSRVLGESIALIMIDLDRFKDVNDSYG
                     HLAGDAVLRGVADVIRDCTREGDLACRYGGSAGDEFLVLLPASELDAALAVAERIRAGI
                     TGMSVTAKVTRDLTTTIEGQTASIGVATYGLGDLVELDLEDLMLDADVSLRAAKRHGRD
                     RICVANMDVSATAESASQATKRMATWARFRRLRSV"
     gene            5721..6416
                     /locus_tag="FHR82_RS25600"
                     /old_locus_tag="FHR82_005211"
     CDS             5721..6416
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099899.1"
                     /locus_tag="FHR82_RS25600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005211"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_184813026.1"
                     /transl_table=11
                     /translation="MLVVGFPTGAFQANCYLVAAGEGEPCVIVDPGQDAVEPVAEALRK
                     YRLSPVAALLTHGHFDHVFSVTPICDGNDIAAWIHPEDRTMLSDPMKGLSDQSSAFFGG
                     KLEMREPAEVRELTDGAELDLAGLTLTVDHTPGHTRGSVVFHTALDEGGRVMFAGDTLF
                     AGSIGRTDLPGGDMRTMTETLRTKILPLADDTVVLPGHGGSTTIGRERASNPFLLELDP
                     TAAGPARGI"
     gene            6418..7053
                     /locus_tag="FHR82_RS25605"
                     /old_locus_tag="FHR82_005212"
     CDS             6418..7053
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800540.1"
                     /locus_tag="FHR82_RS25605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005212"
                     /product="hypothetical protein"
                     /protein_id="WP_184813027.1"
                     /transl_table=11
                     /translation="MHGDNGEPVPLDLAELSSARRRGCVSFGVALVFGAAIGGIVALFA
                     GQTAALVTAAVVVVLLTLLAWVSGRRKLTLEGDRVVSKAVGRKSVDLVHVDKIELMVTD
                     IRGTRTVGLLLTGGRKSINLALAVYSGAGGRELGILVLRRLADVLARSENTSGLVYSQL
                     LVAQLRAEAKGDVAADRPLYRLATLAQGGRLAQRIKPEAVTRFVASLD"
     gene            complement(7010..8389)
                     /locus_tag="FHR82_RS25610"
                     /old_locus_tag="FHR82_005213"
     CDS             complement(7010..8389)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099906.1"
                     /locus_tag="FHR82_RS25610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005213"
                     /product="YibE/F family protein"
                     /protein_id="WP_376706444.1"
                     /transl_table=11
                     /translation="MRTVITALLIPFALAAAVGVVLLYPFGASPETNSGGGTPVQGVIT
                     ATATGACNGEVQVGAQEEDGDRCLVVDVRMTDGPAPEQQIRTIIPIEPSTPRFTVDDEV
                     VLSYGGGDPADGQSYQLVDFQRGVPLALLAALFAVAVLVLGRWQGLKALGALVISFLVL
                     VFFVLPAIISGESPLLVAIVGAGVIMFVVLYLTHGLSARTSTAVLGTMISLALIGLLGA
                     LWAAFAKLTGIDDDASTLIATLGHAIDTRGLLLAGVVIGALGVLDDVTVTQTSAVWELR
                     AANPSLSRRELYASALRIGRDHVASAVNTLVMAYAGAALPLLLYSSVSGVGIGNIVTSQ
                     SIAQEIVRTLVGSIGIVAAVPVTTALAAAVAWQEKPAETPVRRRPRPDEKQRQDRERPA
                     DRTRTRRDPAEPRRESAEPRRRADDRVPGDRVPDGERRRAAPAPRPVSRDSRRSESPPP
                     A"
     gene            complement(8582..9664)
                     /locus_tag="FHR82_RS25615"
                     /old_locus_tag="FHR82_005214"
     CDS             complement(8582..9664)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024911.5"
                     /locus_tag="FHR82_RS25615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005214"
                     /product="AAA family ATPase"
                     /protein_id="WP_184813029.1"
                     /transl_table=11
                     /translation="MFSHALVLGKFYPPHAGHHRLIRAAAAAAGRTTVAVLGASVESIP
                     LADRVAWLTEEHAADEGVAIIGDVDDHPIDFHDDAIWDLHVDIVKSVLARRAMRDGDPR
                     RAPVDVVFSSEDYGAELASRLGAKHVSVDPDRTVVAASGTAIRADAPGHWDQLAPATRA
                     GLCARVVVLGAESTGTTTLSRALADHYRAEWVAEEGRRHTEDKFTAATALAGGVPPRLD
                     DLVWTVGDFVDVARRQSQEEDRAARRGGPLLVCDNDAWAATVWCERYLGAAHPDVTSAR
                     RPALYLLTDHAGVPFEQDGWRDGEHRREWMTARFEELLAGRGVPWVKVTGDPAARLRQA
                     VSACDDLLARHFRFNDPLTA"
     misc_feature    9750..9765
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     gene            9812..9910
                     /gene="pqqA"
                     /locus_tag="FHR82_RS25620"
                     /old_locus_tag="FHR82_005215"
     CDS             9812..9910
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670613.1"
                     /locus_tag="FHR82_RS25620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005215"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_184813030.1"
                     /transl_table=11
                     /translation="MDSTELEAWTTPDFVEYETPMEVTAYAARMED"
     gene            10001..10699
                     /gene="pqqC"
                     /locus_tag="FHR82_RS25625"
                     /old_locus_tag="FHR82_005216"
     CDS             10001..10699
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680419.1"
                     /locus_tag="FHR82_RS25625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005216"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_184813031.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.3e-84, bitscore:
                     279.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAEEFVAELRGLSHRYWGTHPFHRRMHAGELSRAELRAWAAN
                     RWYYQCVLPMKDAAIIANCPLPDLRRAWLDRVVYHDGRSDDDLDSGRERWLRLCEAVGL
                     TRAEVLDERHVVPGVRFAVDAYVNFARTRPWLEAVASGLTEMFSGHLMQRRVTDMLTRY
                     DWISRDDLAYFTNRIEAVSGEGKSTLDIVVRHCVTAEQQDAAVAALSFKCDVLWSVLDA
                     IERAADVRET"
     gene            10683..10940
                     /gene="pqqD"
                     /locus_tag="FHR82_RS25630"
                     /old_locus_tag="FHR82_005217"
     CDS             10683..10940
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670611.1"
                     /locus_tag="FHR82_RS25630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005217"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_184813032.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.1e-23, bitscore:
                     78.6, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.2e-12, bitscore: 42.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGKPRLRKGVRLSFDKTRDTHVLLFPEGVLVPNATAAAVLELCD
                     GESTVDDIAAALGTRFRGVRAQDVTDVLTRLADRRVVEWT"
     aSDomain        10695..10931
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FHR82_RS25630_PqqD_RRE.1"
                     /evalue="3.40E-25"
                     /identifier="RREFam006.1"
                     /label="FHR82_RS25630"
                     /locus_tag="FHR82_RS25630"
                     /protein_end="83"
                     /protein_start="4"
                     /score="78.6"
                     /tool="antismash"
                     /translation="PRLRKGVRLSFDKTRDTHVLLFPEGVLVPNATAAAVLELCDGEST
                     VDDIAAALGTRFRGVRAQDVTDVLTRLADRRVVE"
     gene            10931..12016
                     /gene="pqqE"
                     /locus_tag="FHR82_RS25635"
                     /old_locus_tag="FHR82_005218"
     CDS             10931..12016
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658745.1"
                     /locus_tag="FHR82_RS25635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005218"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_184813033.1"
                     /sec_met_domain="PF04055 (E-value: 1e-23, bitscore: 80.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.4e-07, bitscore: 26.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.8e-11, bitscore: 39.2,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.1e-11, bitscore:
                     39.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVTVAPPLGMLAELTHRCPLHCPYCSNPVELTARADELTTGQWL
                     DVLDAARDIGVLQVHLSGGEPLARPDLPELVTRAADLGCYVNLVTSGLGLTEERLADLT
                     DRGLAHVQLSVQGPDAERANRIAGARAHEHKLAAAALVKEAGLPLTVNVVLHKANHDVG
                     ALIALAERMGADRLELANTQYYGWALRNRAALMPTPEQLAAAEPVVRAQARRLRGTMEI
                     VYVVADYYEKYPKPCMYGWGARQLTVAPNGDVLPCPAASAIATLPVDNVKTRPLRDIWY
                     DSESFNAYRGEEWMREPCRTCDRRSVDFGGCRCQAFQLLGDAAATDPVCSRSPDRGVVD
                     LLLRSPGEQEEFVMRGPVAAR"
     gene            12013..12882
                     /gene="pqqB"
                     /locus_tag="FHR82_RS25640"
                     /old_locus_tag="FHR82_005219"
     CDS             12013..12882
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="FHR82_RS25640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005219"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_184813034.1"
                     /transl_table=11
                     /translation="MRVVVLGTAAGGGFPQWNCACRLCAAGRAGSADVPARTQDCLAVS
                     AGDGWYLVNASPDIRAQVLAADVLAPGPGPRDTPLRGALLTDAELDHTMGLLMLREGGG
                     LRVFAPRAVLSALEPVRDTVARYGSWTWSSTVDIPGLAVTTFAVSDKKPRYAAGSTASG
                     PWVVAYRITDPATGGALVYAPCLRSWLDGFDEFVDGAAGVLLDGTFYSPAEMSGTGTST
                     AAQRAMGHVPIDGPDGSLVRIAKHSGIRWCYTHLNNTNPVLDRRSPEYAVVRDAGVEVP
                     LDGTAFEV"
     assembly_gap    12906..13001
                     /estimated_length=96
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            13161..13748
                     /gene="idi"
                     /locus_tag="FHR82_RS25645"
                     /old_locus_tag="FHR82_005220"
     CDS             13161..13748
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="idi"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009942407.1"
                     /locus_tag="FHR82_RS25645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005220"
                     /product="isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_184813035.1"
                     /transl_table=11
                     /translation="MTEQVVLLDEQGHGIGVADKATVHHLDTPLHLAFSCYVFNSRGEL
                     LVTRRARGKKTWPGVVTNSCCGHPGPSEPFVAAVQRRLADELGLPAAPSVDLLLPKFRY
                     RAVMDNGTVENELCPVFRAVTDTAPDLSPDEVDEYGWMSWPLFVSLVTGGELTVSPWCR
                     EQVDQLVALGSDPLTWPVADEAGLPAAARVVA"
     gene            complement(13661..14293)
                     /gene="pnuC"
                     /locus_tag="FHR82_RS25650"
                     /old_locus_tag="FHR82_005221"
     CDS             complement(13661..14293)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015663 - nicotinamide mononucleotide
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0015890 - nicotinamide mononucleotide
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="pnuC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099910.1"
                     /locus_tag="FHR82_RS25650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005221"
                     /product="nicotinamide riboside transporter PnuC"
                     /protein_id="WP_184813036.1"
                     /transl_table=11
                     /translation="MDIVEILGFVSGALCVWLVARQNIWNWPIGIANNVMFLILFWTAG
                     IYADAGLQIVYMGLALYGWWAWLRGGVQHTALTVTRTTRSQWLVLGGLGVLGTAGLTVL
                     LDTVTDSTVPLPDAITTVLSLLATWGQARKKLESWWLWITADVIYVPLYAYKDLWLTAV
                     LYVGFLALCVLGLRNWRADYATTLAAAGSPASSATGQVKGSEPSATS"
     gene            14376..15029
                     /locus_tag="FHR82_RS25655"
                     /old_locus_tag="FHR82_005222"
     CDS             14376..15029
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020494935.1"
                     /locus_tag="FHR82_RS25655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005222"
                     /product="SRPBCC family protein"
                     /protein_id="WP_184813037.1"
                     /transl_table=11
                     /translation="MIDVGEQINAVSRHIGSRVFGQGEARVATISQTYDTDVDDVWDAC
                     TNPERLPRWFLPVTGDLKVGGHYQLEGNAGGTVERCDPPKSFFATWEFNGMVSWIEVRV
                     APESDGRTRLELEHTAHVDDDLWAQYGPGATGIGWDLALWGLVNHLAPGAPAVTPENAE
                     AWTLSPEGIAFVTAAADRWRAAHVESGTDEAAAEAAAARVMAFYTTPPEPPAGD"
     gene            15101..16066
                     /locus_tag="FHR82_RS25660"
                     /old_locus_tag="FHR82_005223"
     CDS             15101..16066
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009950227.1"
                     /locus_tag="FHR82_RS25660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005223"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_184813038.1"
                     /sec_met_domain="DAO (E-value: 1e-37, bitscore: 126.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSLATDNEVLVIGAGVSGLTTAICLADAGWSVRVLARDLPHDTT
                     SEVAGALWGPSFQEPMAKTMAWTDRSLADFTALAEDPGSGVRMAQTLTVSTMPAGDPPP
                     QARAIPELRACEPAELPPGFASGFRAVMPLADMPRYLDHLTARLAAAGVVVEQGTVTSL
                     DEAVREAPLVVNCAGLGATDFGDDSVRPVFGQHVVVTNPGLDLLFMELSMADEWTSYFP
                     HGDRVVCGGVRIPGRWDRTPEPGITDRILARVRALAPRLRDAEVIEVVTGLRPDRPSVR
                     VETEQLGTGWCVHNYGHGGNGVSLSWGCAREVTELAGRLR"
     gene            complement(16063..16425)
                     /locus_tag="FHR82_RS25665"
                     /old_locus_tag="FHR82_005224"
     CDS             complement(16063..16425)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016152.5"
                     /locus_tag="FHR82_RS25665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005224"
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="WP_184813039.1"
                     /transl_table=11
                     /translation="MSENLLRERVAAIVAELPEATCTGDRHLTLAVRKKTFGYFLDDHH
                     GDGVIGVAFKAAPGEQGALVTSDPERFYVPAYLGARGWAALRLDVGEPDWAEVRELLTD
                     AYRLQAPRRLTARLDG"
     misc_feature    complement(16102..16104)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16513..16767
                     /locus_tag="FHR82_RS25670"
                     /old_locus_tag="FHR82_005225"
     CDS             16513..16767
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHR82_RS25670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHR82_005225"
                     /product="hypothetical protein"
                     /protein_id="WP_184813040.1"
                     /transl_table=11
                     /translation="MVRSPLLVVMCAGYFLVLLDVTVVNVALPDIGGALASGPAGLQWV
                     VDGYAIAIAGLLLVGGTVGDVHGHRWSPVSSSRPPGSRC"
     gene            16722..16982
                     /locus_tag="FHR82_RS25675"
                     /old_locus_tag="FHR82_005226"
     CDS             16722..16982
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHR82_RS25675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHR82_005226"
                     /product="hypothetical protein"
                     /protein_id="WP_184813041.1"
                     /transl_table=11
                     /translation="MVAGLLLAAAGFALLTGLRADSSYQVLLPALLLWGLGLAALTPAF
                     GAVAGTASNARAFVSGLHLTGLVAAALFLVAALSTLLMRSN"
     misc_feature    16990..17005
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: strong, score: 27.38"
                     /tool="antismash"
     misc_feature    complement(16991..17004)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 22.52"
                     /tool="antismash"
     gene            17015..18967
                     /locus_tag="FHR82_RS25680"
                     /old_locus_tag="FHR82_005227"
     CDS             17015..18967
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672633.1"
                     /locus_tag="FHR82_RS25680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005227"
                     /product="intein-containing Rv2578c family radical SAM
                     protein"
                     /protein_id="WP_184813042.1"
                     /transl_table=11
                     /translation="MRWESQRVDHDGNDGPGGNGGQQTLPGLPGLVRSVRTPEFANVVF
                     HEVRAKSVLNKVPGQSRMPFGWTVNPYRGCSHACRYCLAGDTPILMADGRTRPLSGLRA
                     GDRIYGTERVGNRRRYVATQVLAHWTTHKPAFRVTLRDGTQLIASGDHRFLTDRGWRHV
                     AEGACEDERRILVPGDRLVGTGHFATPPKGGEDYQCGYLAGIAAGHGEPVDPRVLERAR
                     EFLTGEESISLPIQRPDVPSEEWHKGFLAGVFDVDGDYSRGRLRVGRTGRAVLPEVVAA
                     LRRFDFAFVVEEAGHRSGVCRFRLTGGLGEHLRFLHSVDPAHTGTNELNGVVLRSAAQL
                     AVATIEPLGLELTLYDITTGTGDFIANGVVSHNCFARRTHEYLDLDAGEDFDSQIVVKV
                     NAPEVLATQLRSPRWTREPVAMGTNTDPYQRAEGRYQLMPGIIRALAGSGTPFSILTKG
                     TVLSRDLPLLSEVSKDVEVGVGVSIALVDRELQRKLEPGTASPQARLELVRKIVEAGLP
                     CGVFVAPVLPGLTDSVEQLDALLSSIADTGATGVTVLPLHLRPGAREWFAAWLAREHPR
                     LVPEYRRIYAKGSNADVRYRRWLGTRVGPLLRRHGLGPKATRPVDTAEPGWPDGSLTDP
                     AKAAEPVRQEQLSLL"
     misc_feature    18590..18592
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18686..18688
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18833..18835
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19068..20090)
                     /locus_tag="FHR82_RS25685"
                     /old_locus_tag="FHR82_005228"
     CDS             complement(19068..20090)
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020904.5"
                     /locus_tag="FHR82_RS25685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005228"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_221464322.1"
                     /transl_table=11
                     /translation="MRALGLAEGAHLTDPELTDFWDDHPYSLAHYIEPPPSDELIASIE
                     EELGGYRLPAAYVDLARGHNGGMVRRCCHPLPDDAYLMITGLYAIGRTADYSLCGPLGS
                     TFMLREWGYPPIGVGIADTPSAGHELIMLDYRACGRRGEPRVVHVDQEADYRVTAVAPD
                     FATFVDGLVPEDEFDTAEEDRLEALTTVERGSLSPIVSRALAASRLPDGERALRALGRR
                     IVDEKGYFSLHADESSLLMYRLLFWLYSHLTTASSFEDFLRYDRDRPSYDLPCYELMIV
                     FSLVAEPYGFSTDGFAEGFIRDWWDDEVTSGAIVAVADGYRLTPVAEEQLLHRLSFVVA
                     "
     gene            complement(20054..21091)
                     /locus_tag="FHR82_RS25690"
                     /old_locus_tag="FHR82_005229"
     CDS             complement(20054..21091)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018681977.1"
                     /locus_tag="FHR82_RS25690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_005229"
                     /product="hypothetical protein"
                     /protein_id="WP_311771272.1"
                     /transl_table=11
                     /translation="MVGRDNWGEREETTMGGGATREPVRELHRTGEIRRALPHPVDSLA
                     ADAFPTALRTAIQASGLSLDRIQYRLRARGVSVSVTALSYWQSGRRRPERAESLAALGH
                     LESVLGVAPGSLIALLGPPRPRGRVQRESSRVPIPSLFPGSEALSKLLKRIDFTTETAL
                     TKLSQHDRMDVAADWGEKRIAVRQVLRAERDGVDRTVMVYDLERIGRPFPDVVAGQSCQ
                     IGRVARDEDAGLIAAEILLDAPLARGETAIVEYALNHPGPPYSRGDDSYCRRFTTPVRE
                     FVLEMQFDPDALPAYCELYTVNPEEQTTTRRKVEVTPNGQAHAVALDFGPGTFCVRWDW
                     PRERT"
     misc_feature    complement(20879..20881)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21322..21335
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.58"
                     /tool="antismash"
     misc_feature    21367..21381
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
ORIGIN
        1 gcctcgcacg aggtcggtgt cgagggcgcg cggctggcga aggacccgta cggcgagtcg
       61 tgggtgctca acaacctcgc gcacgcctac cgcgagttac gcaggctgga cgaggcgatc
      121 gcggcgtacg agaagtccct cgccatccgc accgagatcg gcgaccaggt cggcctggcg
      181 tggacgctca ccggcctcgg caacgccggg ttcgaccagg cccgcttcga cgtcgccgcc
      241 gagcacttcg agcgggcgct cgccatgttc cgcggtgtcg gcgaccggca cggcgagggc
      301 atcgcgctcg ccaacctcgg cgacgccatc cgttcgcagc gccagttcga ccgggccgtg
      361 accgtgctgg agcaggcgct ggacctgttc caggacatcg aggaccgcta cggcgagggc
      421 tacacgctcg tgaagctggg ggacacgtac tcggagctga agcggcccgc ggaggccctc
      481 aacttcttcc agcgcgcgct ggcgatccgc cgcgagctgg gggaccgctg gggcgaaggc
      541 gaaaccctgc acaagcaggg cctggccctc tacgacagcg gacaaccgga acaggccagc
      601 gaatgcctcc gtggcgccgt ggccatcttc gacgagctgg gcgacccgag ggccgccgac
      661 ctgaaggaga tcctggccgc ggcacacaag tagggctttg tcaggtgctg ccgggcacgt
      721 cggcgtcccg ttcaacggcg gcccctttca ggggctcggc accgggaccg gcctggccag
      781 cacctggtcc aggacctcgg tgaggaaccg cgccggatcc ggggcaggtg tcgtggtccg
      841 cgtcgcgacg atcccgtccg gtcggacgag cagggcccct tcggcgggga gccacgggac
      901 cgcgacgcgg tgcgcgggaa gtccggtcac cgccgcggcg gtgagccagt gttcgccctc
      961 ggcgcccacc agcagggtcc accgggatgc caccaggtcg agggtcgaga ccccgtcgat
     1021 ccacgcgtgg ggaacccgtg accccggtga accgtccagc gccaccgata ggtccattgt
     1081 ggacggtagt gccggccgcg ggccgacgac ggcggccgag tcgtaccgct ggccgaggtg
     1141 cacgaccggt gccgcccaca cccccgccgc caccctggcg gcgtcggcct cgggtccgcg
     1201 tccccagtgc agttccgggt cggcgagccg gcgcatcgcc tggtccagcg tcgccgcggc
     1261 gaccggttca cgttcgtgcg cgtaggtgtc gagcaggccg gcgcctgcct cgccgcggtg
     1321 gacggcggcc agcttccacg tcaggttgtg cgcgtcggcg acgccggtgt tgaggccgaa
     1381 cgcgccaagg ggtgacacgg tgtgcgcggc gtcgccgacg aggaacacgc ggcccaccgc
     1441 gaagctctcg gccgcggcgc tgcgggggcg ccagggcagc acgctgcgca cctcgacgtc
     1501 gaggtcggga tcgccgaccg ccgcccggac gatcgcggcg cagcgctctg gcgtgaagtc
     1561 ctcggggcat tcgcccgcgt cgacgtcgca ggccacgtgg aatacccagt tcgtctcgcc
     1621 gtccacggtg gccagcaggc ccggtgccgc cggtgtggtg atggtgcagg tggcgaagga
     1681 catgccccgc aggtggggcc ggaggtcggc gcggaacagg atgttgatca tcgacttgcc
     1741 gaggtcgcca ggaccggagg tgcccacgcc gagcgcggtc cgcacggtgc tgtgcgtgcc
     1801 gtcggcggcg accacgtgcg cgcaccgcag cgagtagcgg ccgtcgggtc cttccagctc
     1861 gacgtcgacc ccaccggtgt cctgcgtgat gccggccagg cgggtcgacc agcgcaggtc
     1921 cgcgccgcgg cgcgccaggt cggccgccac gacggcgtcg agccggtcct gggcacacac
     1981 gccgcgcagc ctgaacggcg tcacgtccag ctcgtcggcg gccggggccg gcatgggcac
     2041 ggtcacgaca tcgcccgcgc ccatctcgac gacggtccgc gccaccgcct tgcccgcagc
     2101 accccggagg tcgaccgcgg cggcgtccac ggcggtgtcg agcccgagtt cgcggaggac
     2161 ctcgacggtg cgcggcccga tgccggtggc gcgtgggtgg accgacgggc cggaccggcg
     2221 ttccaccagc accgcgggga cgccgtggtg ggtgagcagc gccgcggtga gcaggccgac
     2281 gctgccgccg ccgaccacga gcaccgggac ttctggatac tctgtgcccg tcatggctac
     2341 accgtagcca gaaggtagga tgcgggtcaa cgaggaaagg aaccgcccga tgaccgaacc
     2401 cgttccctcg tcggtgtgga cacggccgcg ccccgaaccg cgccggcgcg cgcccggggt
     2461 ggaccagtac gtggccgcgg cgatggccgt cgcggacgcg gaggggttgg cggcggtgtc
     2521 gatgcggcgg gtcgcgggcg atctcggctc cgggaccgcc tcgctctacc ggtacatcac
     2581 caaccgcgac gagctggtgg acctgatgat cgacgcggcg cagggcgagg atccgctgcc
     2641 cgagtccgcc ggggactggc gtgccgacct gggggcggtc gcgcacgcgt tgcgcgcgac
     2701 actgctgcgg cacccgtggc tcgcgggtga actggcggga aggcccgcgc tcggccccaa
     2761 ctcgttgcgg cggtccgagt ccgcgctgcg tgccgccgtc gcgctcacgc ccgacatcac
     2821 cctggcctcg cgggcgctcg gcgccgtgca cgcgtacgtg ctgggttcgg tcgccgccca
     2881 gcaggccctt ctgcgcgcgg agcagcgcac cggcctcacc gaggaggagt ggcagcgcag
     2941 cgtcggtccc tacatcagcg aggtcctcgc ggcgggtgag cacccgatgc tcgcccgccg
     3001 cgtcctcgaa gccgaggaac ccgaccccga cgtcgatttc gcgttcggcc tggactgcgt
     3061 gctcgacggg ctcgcggccc ggctgggtcg ctgagcggtc agtgggcctt cagcgcctcg
     3121 aacatgtgct ccaggaacct cggcacgtca acggtttccg ccaccttcac cggcacgcgc
     3181 cccgcgcctg ccgtggtggc gatgtaggcg tcactggcga tcaggcgctg gtcggagacc
     3241 acctggccgc gggtgtgggt gccggagagc tcgatggcga gcggcatctc ccggtacgtg
     3301 gcgagcttcg gctcgagcag cagcgcggcc gcgagcgggt cgtgcagcgt gcacgtgtgc
     3361 gtgccgaaca tctgcgagta gaaacccgcg tagtggtcga gcaaccggtt cgcgaacacc
     3421 gcgcgcgggc tgtcgagcgc gccgaccgcg gtcagccact ccccgcccgc ccgcgcctgt
     3481 tccgtcgcgt cgagaccgac gagggtcatg tcggggaacc ccgccccgag cacgagatcc
     3541 gcggcctccg ggtcgtggaa gaaatttgcg tccgcgtacg gcgtgatgtt tccgggcacg
     3601 gtgaccgcgc cacccatgac gaccacggaa cgtaacaact tgggtaagtc gggttcgagc
     3661 agcacggcga gcgcgatgtt ggtgagcggc ccgagcgcga gcagcgtcag ctcgccggga
     3721 tgcgcacgcg cgagccggac gagttgctcg gccgccgact ccgacaccac ggtcccgctc
     3781 ggctcaggac ccgcgtgacc tcccagtccg tccacgccgt gcacgaactc cgcggtctgc
     3841 agcggctggg cgagcggccg ggcggccccg accgccaccg gcgcggtcag cccgcacaac
     3901 tccatcaccc gcagtgcgtt ccgcgccgcc aacggggcgg aaacattgcc gtggacacta
     3961 cccacagcga cgatctccgc gtcctcctgg gccgcgagat acatgatcgc gagggcgtcg
     4021 tcaacccccg gatcggtgtc gagaatgatg cgcacgctgt ggcactcaac cagacaaccc
     4081 ggcggtaaag ccagaccggg gtggtcaaga tcggcacctg ggtagggtcg atccgtgcgc
     4141 gtgtgtgttt tctgcggatc atcaccaggc aagggcccgg cctaccaggc cgcggcgaag
     4201 cgggtgggcg aggtgttcgc cgagcggggc atcgagctcg tctacggcgg cgcgagtgtc
     4261 ggcacgatgg gtgtggtcgc cgacacggtg ctcgagcacg gcggcaaggt ccacggcgtc
     4321 atcccccaga gcctcgtcga ccgggaggtc gcccacccgg ggctcacgac gctgaaggtc
     4381 gtcgccgacc tgcacgagcg caaggcggcg atgtcggagc tggccgacgg ctacctcacg
     4441 ctgcccggcg gcgccggcac gctcgaggag ctgttcgagg tgttcacgtg ggcgcagctc
     4501 ggactgcacg acaagccgat cgccctgctc gacgtgggtg gttactacca gccgatgttg
     4561 agatttctcg agaacatgtc cgccgagggc ttccttgcgg acgactttcg ggggatgctc
     4621 atcgtcacca ccgaggtcac cgaggcgctc gatcggttcg tcgactaccg cccgccccgg
     4681 acaaagtgga catgagatca ctgcgagtga tcacccagtg cgtaccgtga ctcccccatt
     4741 cggtgtttcc tgaaaccctc aacatgtcaa cactgtgcaa ccgccacgtg actccccata
     4801 gttggcggta acggccggtg aggggtgttg acaatgcgtc cattggggac accggtcggg
     4861 gacaccagtc acgggtgcga ctgacagggg agacggcatg cacacggcca gggcgggaac
     4921 cggcggaggc gcggaccacg cggaccactc cgaccggcac gagcacgtgg acatcgtggc
     4981 gccgaggtcg ggggaccggc cgctgcagtc cgtcaccgcc gccgcacacc accgccgctg
     5041 cgactcgtgt ggccagctgc tgaccgatcc gcccaccggg ctgatcgagc gctggcactg
     5101 ggacgaggtc gcggccgaga ccgtcgcgca gtcgcgagtc ctcggcgagt cgatcgcgct
     5161 gatcatgatc gacctggacc gcttcaagga cgtcaacgac agctacgggc acctcgccgg
     5221 ggacgcggtg ctgcgcggtg tcgcggacgt catccgggac tgcacccgcg agggcgacct
     5281 cgcctgccgc tacggcggct cggccggtga cgagttcctg gtgctgctgc ccgcgtccga
     5341 gctggacgcc gcgctcgcgg tcgcggagcg catccgcgcc ggcatcacgg gcatgtcggt
     5401 gaccgcgaag gtgacccgcg acctgacgac caccatcgag ggccagaccg cgtcgatcgg
     5461 cgtggccacc tacggtctcg gcgacctggt cgagctggac ctcgaggacc tgatgctgga
     5521 cgcggacgtg tcgctgcgcg cggcaaagcg ccacggccgg gaccgcatct gtgtggccaa
     5581 catggacgtg agcgccacgg ccgagtcggc cagccaggcc accaagcgga tggccacctg
     5641 ggcccgtttc cgtcgcctca ggtcggtctg agcgaacctg cgagcggagc gagccagatc
     5701 agcacggtaa gttcggggcc gtgctggttg tcggatttcc cacgggtgcg ttccaggcca
     5761 actgttatct cgtcgcggcg ggtgagggcg agccgtgcgt gatcgtcgac ccgggacagg
     5821 acgcggtcga accggtcgcc gaggcactgc gcaagtaccg gctctcaccg gtggcggcac
     5881 tgctgacgca cggccacttc gaccacgtct tctcggtcac cccgatctgc gacggcaacg
     5941 acatcgccgc ctggatccac ccggaagacc gcacgatgct cagcgacccc atgaaggggc
     6001 tgagtgacca gagctccgcg ttcttcggcg gcaagctcga gatgcgggag ccggccgagg
     6061 tgcgggagct gaccgacggc gcggaactcg acctcgcggg cctcacgctg accgtggacc
     6121 acacgccggg ccacacgcgt ggctcggtcg tgttccacac cgcgctggac gagggtggcc
     6181 gcgtcatgtt cgcgggcgac acgctcttcg ccgggtcgat cggccgcacc gacctgcccg
     6241 gcggtgacat gcggacgatg accgagacgc tccgcacgaa gatcctcccg ctcgccgacg
     6301 acaccgtggt gctgcccggg cacggcggca gcaccacgat cgggcgggaa cgcgcgagca
     6361 acccgttcct cctcgagctg gaccccaccg cggcaggccc ggcgcggggc atctgaggtg
     6421 cacggagaca acggcgaacc cgtcccgctc gacctcgcgg aactgtccag cgcccggcgg
     6481 cgcggctgtg tgtccttcgg cgtcgcgctc gtgttcggcg cggcgatcgg cggcatcgtg
     6541 gccctcttcg cgggccagac cgccgcgttg gtcaccgccg ccgtggtggt cgtgctgctg
     6601 acgctcctcg cgtgggtgtc cggcaggcgc aagctcacgc tcgagggcga ccgcgtggtg
     6661 tcgaaggcgg tcggccgcaa gtcggtcgac ctggtgcacg tcgacaagat cgagctgatg
     6721 gtgaccgaca tccgcggcac caggacggtc gggctgctgc tcaccggcgg tcgcaagtcg
     6781 atcaacctgg cgctggccgt ctactccggc gccggcgggc gcgagctggg catcctcgtg
     6841 ctgcgcaggc tcgccgacgt gctggcccgc agcgagaaca cgtccgggct ggtgtactcc
     6901 cagctcctgg tggcccagct gcgggcggag gccaaggggg acgtggccgc cgaccggccg
     6961 ctgtaccgcc tcgcgaccct ggcgcagggc ggcaggctcg cccagcgcat caagccggag
     7021 gcggtgactc gcttcgtcgc gagtctcgac tgaccggccg gggtgccggc gcggccctgc
     7081 gccgctcccc gtcaggcacg cggtcacccg gcacgcggtc atccgcccgc cgcctcggct
     7141 ccgcggactc tcgccgcggt tccgccgggt cccgcctggt gcgggtccgg tccgcgggtc
     7201 gttcgcggtc ctggcgttgc ttctcgtccg gccgcggcct gcgccgcacg ggcgtctcgg
     7261 caggcttctc ctgccaggcg accgcggccg cgagcgcggt ggtcaccggt accgcggcga
     7321 cgatgccgat gctcccgacc agcgtccgca cgatctcctg cgcgatcgac tgcgacgtca
     7381 cgatgttgcc gatgccgacc ccggacaccg acgagtacag cagcagcggc agcgcggcac
     7441 ccgcgtaggc catgacgagc gtgttcaccg ccgacgccac gtggtcgcgc ccgatccgca
     7501 gcgccgacgc gtacagctcg cgccgcgaca gcgacgggtt cgccgcccgc agctcccaca
     7561 cggcgctggt ctgcgtcacg gtcacgtcgt cgagcacacc gagcgcgccg atcaccacgc
     7621 ccgcgagcag cagcccgcgc gtgtcgatgg cgtggcccag cgtcgcgatc agcgtcgacg
     7681 cgtcgtcgtc gatgcccgtg agcttggcga acgcggccca cagcgcgccg agcagcccga
     7741 tcagcgcgag gctgatcatc gtgccgagca cggcggtcga cgtccgcgcg gacagcccgt
     7801 gcgtcaggta caggaccacg aacatgatca cgcccgcgcc gacgatcgcc accagcagcg
     7861 ggctctcccc gctgatgatc gcgggcagca cgaagaacac gagcaccagg aagctgatga
     7921 cgagcgcgcc gagcgccttg agcccctgcc accgcccgag caccagcacc gcgaccgcga
     7981 acaacgcggc gagcagcgcg agcggcaccc cccgctggaa gtcgaccagc tggtaggact
     8041 gcccgtcggc cgggtcacca ccgccgtagg acaggacgac ctcgtcgtcg accgtgaacc
     8101 gcggcgtgga cggttcgatc gggatgatcg tgcggatctg ctgctcgggc gcgggcccgt
     8161 cggtcatccg gacgtcgacg acgagacagc ggtcgccgtc ctcctcctgc gcaccgacct
     8221 gcacctcgcc gttgcacgcg ccggtggccg tggccgtgat gacgccctgc accggggtgc
     8281 cgccgcccga gttcgtctcc ggcgacgcgc cgaacgggta cagcagcacg acgccgacgg
     8341 ccgcggcgag cgcgaacggg atcagcagcg ccgtgatgac cgtgcgcacg cggtgggacg
     8401 cgggcggggc gggggtgtgg ccgtgaccgt gaccgcgact gcgaccgtca ccgtgaccgg
     8461 ccgaggatgg ctcgtcccct gagggctccg cgtccggttc ctcccggcgt cggcgcgtcg
     8521 gcccggggtc ggtgacccgg gggatcggtt cggtctcgcc ctcgtacacc cgcgcagtct
     8581 ctcaggccgt cagcggatcg ttgaaccgga agtgccgggc gagcaggtcg tcgcacgcgg
     8641 agaccgcctg ccgcagccgt gccgccgggt cgccggtgac cttcacccac ggcaccccgc
     8701 gcccggcgag caactcctcg aaccgcgcgg tcatccactc ccgccggtgc tcgccgtcgc
     8761 gccacccgtc ctgctcgaac ggcacgcctg cgtggtcggt gagcaggtac agcgcgggcc
     8821 ggcgtgcgga cgtcacgtcc gggtgggcgg cgccgaggta acgctcgcac cacacggtcg
     8881 cggcccacgc gtcgttgtcg cacacgagca gcggcccgcc ccgccgggcc gcgcggtcct
     8941 cctcctgtga ctggcggcgc gccacgtcga cgaagtcgcc gacggtccac accaggtcgt
     9001 cgagccgcgg cggcacgcca cccgcgagcg cggtggcggc ggtgaacttg tcctcggtgt
     9061 gcctgcgccc ctcctcggcg acccactcgg cgcggtagtg gtccgcgagc gccctgctga
     9121 gcgtggtggt gccggtggac tcggcgccga gcacgaccac ccgcgcgcac agcccggcgc
     9181 gggtggcggg ggcgagctgg tcccagtgcc ccggggcgtc ggccctgatc gcggtgccgg
     9241 acgcggccac gaccgtgcgg tccgggtcca cggacacgtg cttggcgccc agcctgctgg
     9301 ccagctcggc gccgtagtcc tcgctggaga acacgacgtc gaccggggcg cggcgggggt
     9361 cgccatcgcg catggcgcgg cgcgcgagca ccgacttcac gatgtcgacg tgcaggtccc
     9421 agatcgcgtc gtcgtggaag tcgatggggt ggtcgtcgac gtcgccgatg atcgcgacgc
     9481 cctcgtcggc ggcgtgttcc tcggtgagcc aggcgacccg gtcggccagc gggatcgact
     9541 cgaccgaggc accgagcacg gccacggtcg tgcgccccgc cgccgccgct gccgcccgga
     9601 tcagccggtg gtggcctgcg tgcggcgggt agaacttccc caggaccagc gcgtgggaga
     9661 acatgcgagc atcgtcccgc agtggccgat tcccgggtca cggtggtgcc cgaacggggg
     9721 aaaccgcttg ccttgcggta ttcacatccg tcacgttgcc gttacgctgg ggagcgcccg
     9781 gatagaccgc acgtctcgcg ggaggtaacc catggacagc accgagctgg aggcctggac
     9841 gactccggac ttcgtcgagt acgagacgcc gatggaggtc accgcctacg ccgcgcgtat
     9901 ggaggactga cccctgatac tgcccggcgc ggccgtcctg ctggggagcg acccccaaga
     9961 gcccggtccc gcgccgggca gtcctgtcgg aaggtgaccc gtgatccgca ccgctgagga
    10021 gttcgtcgcc gaactccgtg gcctctccca ccgctactgg ggcacgcacc cgttccaccg
    10081 gcgcatgcac gcgggcgagc tgtcccgcgc cgagctgcgg gcctgggccg ccaaccgctg
    10141 gtactaccag tgcgtgctgc cgatgaagga cgcggcgatc atcgccaact gcccgctgcc
    10201 ggacctccgg cgcgcgtggc tcgaccgcgt cgtctaccac gacggccgct ccgacgacga
    10261 cctcgacagc ggccgcgagc gctggctgcg gctgtgcgag gccgtggggc tcacccgtgc
    10321 cgaggtgctg gacgaacggc acgtcgtgcc cggcgtccgg ttcgccgtcg acgcgtacgt
    10381 gaacttcgct cgcacccggc cgtggctgga ggcggtcgcg tccgggctca ccgagatgtt
    10441 ctccgggcac ctcatgcagc gccgcgtcac ggacatgctg acgcgctacg actggatctc
    10501 ccgcgacgac ctggcgtact tcaccaaccg catcgaggcg gtgtccggcg aggggaagtc
    10561 cacgttggac atcgtggtgc gccactgcgt caccgcggag cagcaggacg cggcggtggc
    10621 ggcgctgtcg ttcaagtgcg acgtcctgtg gtcggtgctg gacgcgatcg agcgggcggc
    10681 cgatgtccgg gaaacctagg ctgcgcaagg gagtgcggct ctccttcgac aagacgcggg
    10741 acacgcacgt gctgctgttc cccgagggtg tgctggtgcc caacgcgacc gcggcggcgg
    10801 tgctggagct gtgcgacggg gagtccacgg tggacgacat cgccgccgcg ctcggcaccc
    10861 ggttccgggg cgtgcgcgcg caggacgtga ccgatgtgct gaccaggctg gcggaccgga
    10921 gggtcgtgga atggacgtga ccgtcgcgcc accactcggc atgctggccg agctgacaca
    10981 ccgctgcccg ctgcactgcc cgtactgctc caacccggtc gagctgacgg cgcgtgccga
    11041 cgagctgacc acggggcagt ggctggacgt gctggacgcg gccagggaca tcggcgtgct
    11101 gcaggtgcac ctgtccggcg gcgagccgct ggcccgcccc gacctgccgg agctggtcac
    11161 ccgggccgct gacctcggct gctacgtcaa cctcgtcacc agcggtctcg ggctgaccga
    11221 ggagcggctc gcggacctca ccgaccgagg gctcgcccac gtgcagctgt ccgtgcaggg
    11281 cccggacgcg gaacgggcga accgcatcgc cggtgcccgc gcgcacgagc acaagctcgc
    11341 cgccgcggca ctggtcaagg aagccggcct gccgctgacg gtgaacgtgg tgctgcacaa
    11401 ggcgaaccac gacgtcggcg ccctcatcgc gctcgcggaa cggatgggtg cggaccggct
    11461 ggagctggcg aacacgcagt actacggctg ggcgctgcgc aaccgggcgg cgctcatgcc
    11521 gacgccagaa cagctcgcgg cggccgagcc ggtcgtgcgg gcacaggcgc ggcggctgcg
    11581 cgggacgatg gagatcgtct acgtcgtggc cgactactac gagaagtacc cgaagccgtg
    11641 catgtacggg tggggcgcac ggcagctgac cgtcgcgccg aacggggacg tgctgccgtg
    11701 ccccgcggcg tcggcgatcg ccacgctgcc ggtggacaac gtgaagacgc ggccgctgcg
    11761 ggacatctgg tacgactcgg agtccttcaa cgcctaccga ggcgaggagt ggatgcgcga
    11821 gccgtgccgg acgtgtgacc gccggtcggt cgacttcggt ggctgccggt gtcaggcgtt
    11881 ccagctgctc ggcgacgcgg cggcgacgga cccggtgtgc tcgcggtcgc cggaccgcgg
    11941 ggtggtcgac ctgttgttgc ggtcgccggg ggagcaggag gagttcgtca tgcgtggtcc
    12001 ggtggcggca cgatgagggt ggtcgtgctt ggcaccgccg cggggggcgg gttcccgcag
    12061 tggaactgcg cgtgccggct gtgcgcggcg ggccgcgctg ggtcggcgga cgtgcccgcg
    12121 cggacgcagg actgcctcgc cgtgagcgcg ggcgacggct ggtacctggt caacgcgtca
    12181 cccgacatcc gcgcccaggt cctggcggcg gacgtgctgg cgcccgggcc aggtccgcgg
    12241 gacacgccgt tgcggggcgc gttgctgacc gacgcggaac tggaccacac gatgggcctg
    12301 ctgatgctcc gcgagggcgg cgggctgcgg gttttcgcgc cgcgggcagt gctgtccgcg
    12361 ctcgaaccgg tccgggacac cgtcgcccgc tacgggtcgt ggacctggtc gtccacagtg
    12421 gacataccgg ggctcgcggt gacgacgttc gcggtgagtg acaagaaacc caggtacgcg
    12481 gccggctcca cggcgtccgg tccgtgggtg gtggcgtacc gcatcaccga cccggcgacc
    12541 gggggcgcgc tcgtctacgc gccgtgcctg cggtcgtggc tggacgggtt cgacgagttc
    12601 gtcgacggcg ccgccggtgt gctgctcgac ggcacgttct actcgcccgc ggagatgtcg
    12661 ggtacgggga cgtccaccgc ggcccagcgc gcgatgggcc acgtgccgat cgacgggccg
    12721 gacggcagcc tcgtgcggat cgcgaagcac tccggcatcc gctggtgcta cacgcacctg
    12781 aacaacacca acccggtgct ggaccgccgc tcaccggagt acgcggtcgt gcgggacgcc
    12841 ggggtggagg tgccgcttga tgggacggca ttcgaggtct gagcggagct tgcggagcga
    12901 gccaannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nccaagggtg ctgagcggag
    13021 cttgcggagc gagccaaggg tgctgagcgg agcttgcgga gcgagccaag ggtgctgagc
    13081 ggagcttgcg gagcgagcca agggtgctga gcggagcttg cggagcgagc cgtggctgcc
    13141 gtgcggctat cctcggtgaa gtgacagaac aggtcgtcct gctcgacgag caggggcacg
    13201 ggatcggggt cgccgacaag gcgacggtgc accacctcga cacgcccctg cacctcgcct
    13261 tctcgtgcta tgtgttcaac tcgcgcggtg agctgctggt gacgcggcgg gcgcggggga
    13321 agaagacgtg gccgggcgtg gtgaccaaca gctgctgcgg tcaccccggg ccgtccgagc
    13381 cgttcgtggc cgccgtccag cgcaggctcg ccgacgagct gggcctgccc gcggcgccga
    13441 gtgtcgacct gctgttgccg aagttccggt accgcgcggt gatggacaac ggcaccgtcg
    13501 agaacgagct gtgcccggtg ttccgcgcgg tcaccgacac ggcgccggac ctgtcgccgg
    13561 acgaggtgga cgagtacggc tggatgtcct ggccgctgtt cgtcagcctc gtgaccggcg
    13621 gcgagctgac cgtgtcgccg tggtgccggg agcaggtcga tcagctggtg gcgctgggtt
    13681 cggacccctt gacctggccg gtcgcggacg aggccggact gcctgcggcg gccagggtcg
    13741 tcgcgtagtc ggcgcgccag ttgcgcaggc cgagcacgca cagtgcgagg aagccgacgt
    13801 acaggaccgc ggtaagccac aggtccttgt aggcgtagag cggcacgtag atgacgtccg
    13861 ccgtgatcca cagccaccac gactcgagct tcttgcgtgc ctgcccccac gtggcgagca
    13921 gggacagcac ggtcgtgatc gcgtccggca gcggcacggt cgagtcggtc accgtgtcga
    13981 gcaggacggt cagcccggcc gtgccgagca ccccgaggcc gccgagcacg agccactggc
    14041 tccgggtcgt gcgggtgacg gtcagcgccg tgtgctggac gccgccgcgt agccaggccc
    14101 accagccgta cagcgcgagc cccatgtaga cgatctgcag gccggcgtcc gcgtagatcc
    14161 cggccgtcca gaacaggatc aggaacatga cgttgttcgc gatcccgatg ggccagttcc
    14221 agatgttctg cctggcgacg agccacacgc acaacgcgcc cgacacgaac ccgaggatct
    14281 cgacgatgtc cacccatgcc cctttagtgt tgacttatat aagtgggact cgatacggtg
    14341 ctgtccccga ccaatgacac cagaggagac ccccgatgat cgatgtcggt gagcagatca
    14401 acgcggtgag ccgccacatc ggcagccgcg tgttcggcca gggggaggca cgcgtcgcga
    14461 cgatcagcca gacctacgac acggacgtcg acgacgtgtg ggacgcgtgc accaacccag
    14521 agcggctccc gaggtggttc ctgccggtca ccggcgacct gaaggtgggc gggcactacc
    14581 agctcgaagg gaacgcgggt ggcaccgtcg agcgctgcga cccgcccaag agcttcttcg
    14641 cgacgtggga gttcaacggg atggtcagct ggatcgaggt ccgggtcgcg ccggagtccg
    14701 acggcaggac ccgccttgag ctggagcaca ccgcccacgt cgacgacgac ctgtgggcgc
    14761 agtacggccc cggcgcgacc ggcatcggct gggacctggc cctctggggc ctggtgaacc
    14821 acctggcgcc cggcgccccg gccgtgaccc cggagaacgc cgaggcgtgg accctgtcgc
    14881 ccgagggcat cgcgttcgtg acggccgcgg ctgatcgctg gcgggccgcc cacgtcgagt
    14941 cgggcaccga cgaggcggcc gcggaggccg cggcggcacg cgtgatggcc ttctacacga
    15001 ccccgcccga gcctccggcc ggcgactgac cggggactga aggtggccgg ctgcccgctc
    15061 gcgtggtccg gcgggcagcc gcctcgtagg ctcggctgcc atggactcgc ttgccacgga
    15121 caacgaggtg ctcgtgatcg gcgcgggggt cagcggcctg accaccgcca tctgtctcgc
    15181 cgacgcgggc tggtccgtcc gcgtactggc gcgtgacctc ccgcacgaca ccacgtccga
    15241 ggtcgcgggc gcgctgtggg ggccgtcgtt ccaggagccc atggccaaga ccatggcgtg
    15301 gaccgaccgg tccctcgccg acttcaccgc gctcgccgag gaccccgggt ccggagtgcg
    15361 catggcgcag accctcaccg tcagcaccat gcccgccggt gacccgccgc cgcaggcacg
    15421 cgccatcccc gagcttcgcg cgtgcgagcc ggccgagctc ccgccgggct tcgccagtgg
    15481 cttccgcgcg gtcatgccgc tcgccgacat gccccgctac ctcgaccacc tgaccgcacg
    15541 cctggcggcg gcgggagtgg tggtcgagca ggggaccgtg acctcgctgg acgaggccgt
    15601 ccgcgaggcg ccgctggtcg tcaactgcgc cggtctcggc gctacggatt tcggcgacga
    15661 cagcgttcgc ccggtgttcg ggcagcacgt ggtcgtcacg aacccaggtc tggacctcct
    15721 gttcatggaa ctgtcgatgg ccgacgagtg gacgagctac ttcccgcacg gcgaccgcgt
    15781 cgtctgcggt ggcgtgcgca tccccggccg ctgggaccgc acaccggaac ccgggatcac
    15841 cgaccggatc ctggcgcggg tccgcgcgct ggcgccacgc ctacgggacg cggaggtgat
    15901 cgaggtcgtc accggcctgc gccccgaccg gccgtcggtg cgcgtggaga ccgaacagct
    15961 cggtaccggg tggtgcgtcc acaactacgg gcacggcggt aacggcgtca gcctctcgtg
    16021 gggctgcgcc cgcgaggtca ccgagctggc cggccggctg cgctagccgt ccagccgcgc
    16081 ggtgagcctg cgcggcgcct gtaatcggta cgcgtcggtg agcagctccc gcacctcggc
    16141 ccagtcgggc tcgcccacgt ccagccgaag cgccgcccag ccgcgggcgc cgaggtacgc
    16201 gggcacgtag aagcgctccg ggtccgacgt caccagcgcg ccctgctcac cgggtgccgc
    16261 cttgaacgcc accccgatga ccccgtcgcc gtggtggtcg tcgaggaagt agccgaacgt
    16321 cttcttgcgc acggccagcg tcaggtgccg gtcgccggtg cacgtcgcct ccggcagctc
    16381 tgcgacgatc gcggcgaccc gctcgcggag caggttctcg gacatgggag gacgctagcg
    16441 cgcaccaccg acagttccgg gcgcggcgag agttcgcctg tcaccgaacg gttccggcgc
    16501 gacactcgga gcatggtccg ctcgccgcta ctggtcgtca tgtgcgccgg gtacttcctg
    16561 gtcctgctcg acgtcaccgt cgtcaacgtg gcgctcccgg acatcggcgg cgcgctcgcg
    16621 tccggtccgg ccggcctcca gtgggtggtc gacggctacg cgatcgccat cgccgggttg
    16681 ctcctcgtcg gcggcaccgt cggcgacgtc cacggccacc gatggtcgcc ggtctcctcc
    16741 tcgcggccgc cgggttcgcg ctgctgaccg ggctgcgggc ggactcgtcc taccaggtgc
    16801 tcctgcccgc gctgctgctc tggggcctcg ggctcgctgc cctcaccccg gcgttcggag
    16861 cggtcgcggg cactgcgtcg aacgcgcggg cgttcgtgtc cgggctgcac ctgaccggcc
    16921 tcgtcgcagc cgcgttgttc ctggtagcgg cgttgtccac actgctcatg cgttcgaatt
    16981 gacacgagtt cgaacgtgtg ttcgactatg ccccgtgcga tgggaaagcc agcgcgtcga
    17041 tcatgacggc aacgacggcc ccggtggcaa cggcggccag cagacactgc ccggtctccc
    17101 cgggctggtg cgcagcgtgc gcaccccgga gttcgcgaac gtcgtcttcc acgaggtgcg
    17161 ggccaagtcc gtgctgaaca aggtgcccgg ccagtcgcgg atgccgttcg ggtggacggt
    17221 caacccgtac cgcgggtgca gtcatgcctg ccggtactgc ctcgcggggg acaccccgat
    17281 cctgatggcc gacggccgca ccagaccgtt gtccgggctg cgcgcgggcg accggatcta
    17341 cggcacggag cgggtcggca accggcgcag atatgtcgcg acccaggtgc tcgcgcactg
    17401 gaccacgcac aagcccgcgt tccgggtcac gctgcgcgac ggcacacagc tcatcgccag
    17461 cggcgatcac cgcttcctca ccgaccgcgg ctggcggcac gtcgcggagg gcgcgtgcga
    17521 ggacgagcgg cggatcctcg tgccgggcga ccggctggtc ggcaccggcc acttcgcgac
    17581 cccgcccaaa ggcggcgagg actaccagtg cggctacctg gccggcatcg cggcggggca
    17641 cggcgagccg gtcgacccga gggtgctcga acgggccagg gagttcctga ccggggagga
    17701 gtcgatcagc ctgccgatcc agcgtcccga tgtgccgagc gaggagtggc acaagggttt
    17761 cctggccggc gtgttcgacg tggacgggga ctactccagg gggcgcctgc gggtcggtcg
    17821 cactggccgc gccgtgctgc cggaggtcgt cgcggcgttg cggcgcttcg acttcgcctt
    17881 cgtcgtggag gaggcggggc accgcagcgg cgtgtgccgc ttccggctga ccggcgggct
    17941 gggggagcac ctgcgcttcc tgcactcggt ggaccccgcg cacaccggca ccaacgagct
    18001 gaacggtgtc gtcctgcgct ctgcggcgca gctcgcggtg gcgacgatcg agccactcgg
    18061 cctggaactg acgctgtacg acatcaccac gggcaccggc gacttcatcg ccaacggcgt
    18121 cgtcagccac aactgcttcg cccgccgcac acacgagtac ctcgacctcg acgccggcga
    18181 ggacttcgac tcgcagatcg tggtcaaggt caacgcaccc gaggtgctgg ccacccaact
    18241 gcgctcgccg cgctggaccc gcgaacccgt cgcgatgggc accaacaccg acccctacca
    18301 acgcgccgag ggccggtacc agctgatgcc ggggatcatc cgagccctcg ccggcagcgg
    18361 caccccgttc agcatcctca cgaagggcac ggtcctgtcc cgcgacctgc cactcctgtc
    18421 cgaggtgagc aaggacgtcg aggtgggtgt tggcgtgtcg atcgccttgg tggaccggga
    18481 actgcaacgc aagctggaac cgggcacggc aagtccccag gcgagactgg agctggtccg
    18541 caagatcgtg gaggccggcc tgccctgcgg tgtgttcgtg gccccggtgt tacctggtct
    18601 aaccgactcg gtagagcagt tggacgcact gctgtcgtcg atcgccgaca ccggggcgac
    18661 cggcgtgaca gtgctgccac tccatttacg cccgggcgcg agagagtggt tcgccgcgtg
    18721 gctggcacgc gaacacccac ggctcgtgcc ggagtaccgc cgcatctacg ccaaaggcag
    18781 caacgcggac gtgcgctacc gccgctggct gggcaccagg gtcggcccgc tgttacgcag
    18841 gcacggcctg ggtccgaaag cgacgcggcc tgtggacacg gctgaacctg gctggccgga
    18901 cggcagcctg accgacccgg cgaaggccgc ggaaccggtg cggcaggaac agctgtcgct
    18961 gctgtgatga cgtgagggca cgtgcgagga caggcgcctg tcctcgcgta cctcgcgatc
    19021 agcatcccgt ccggcatcga ccgcggtgat cgacgtgtgt cgtcacctca cgcgacgacg
    19081 aagctgaggc gatgcagcaa ctgttcctcc gcgaccggag tcaggcggta gccatcggcc
    19141 accgcgacga tcgcgccgga cgtgacctcg tcgtcccacc agtcgcggat gaatccctcc
    19201 gcgaacccgt ccgtgctgaa tccatacggt tcggcgacga gcgagaacac gatcatcagc
    19261 tcgtaacagg gcaggtcgta cgaaggcctg tccctgtcgt agcgcaggaa gtcctcgaag
    19321 gacgacgccg tcgtcaggtg ggagtacagc cagaagagaa gccggtacat gagcagtgag
    19381 gactcgtcgg cgtgcagtga gaaatagccc ttctcgtcga cgatccggcg ccccagcgcc
    19441 cgcagcgccc gctccccgtc cggtagccgg gacgccgcca gggcacgcga cacgatcggc
    19501 gacaaggaac cgcgctcgac cgtggtcagg gcctccaagc ggtcctcctc ggcggtgtcg
    19561 aactcgtcct cgggaaccag gccgtcgacg aacgtcgcga agtccggtgc gaccgccgtg
    19621 acgcgatagt cggcttcctg gtcgacgtgc acgacccggg gctcgccgcg gcggccgcag
    19681 gcgcggtagt cgagcatgat cagctcgtgg cccgcggacg gggtgtccgc gatgccgaca
    19741 ccgatcggcg gatatcccca ctcacgcagc atgaacgtcg atcccagtgg cccgcacagc
    19801 gagtagtccg cggtccggcc gatcgcgtaa aggccggtga tcatgagata ggcgtcgtcg
    19861 ggaagcgggt ggcagcaccg ccgcaccatg ccgccgttgt ggccgcgcgc gaggtcgacg
    19921 taagccgcgg gcagccggta cccgcccagc tcctcctcga tcgaggcgat cagctcatcg
    19981 ctcggtggcg gctcgatgta gtgcgccagc gagtacgggt ggtcgtccca gaaatccgtg
    20041 agctcgggat cggtcaggtg cgctccctcg gccagtccca gcgcacgcag aacgtgcccg
    20101 gaccgaagtc gagcgcgacc gcgtgtgcct ggccgttggg tgtgacctcg accttgcgcc
    20161 gcgtcgtggt ctgctcctcc gggttgaccg tgtacagctc gcagtacgcc ggcagggcgt
    20221 ccgggtcgaa ctgcatctcg agcacgaact cacgcaccgg cgtcgtgaac cgcctgcagt
    20281 agctgtcgtc accgcgtgag tagggcgggc cggggtggtt gagcgcgtac tcgacgatcg
    20341 ccgtctcgcc gcgggccagg ggtgcgtcga gcaggatctc ggccgcgatg aggccggcgt
    20401 cctcgtcccg ggcgacccgg ccgatctggc acgactggcc tgccacgacg tccgggaacg
    20461 gcctgccgat ccgttcgagg tcgtacacca tgacggtccg gtcgacgccg tcgcgctcgg
    20521 cacgcagcac ctgccgcacc gcgatccgct tctcgcccca gtcggccgcg acgtccatgc
    20581 ggtcgtgctg cgagagcttc gtcagcgccg tctccgtggt gaagtcgatg cgcttgagca
    20641 gcttcgacag cgcctcactg cccgggaaca gcgacgggat cggtacccgc gacgactccc
    20701 gctgcacacg gccgcgcggg cgcggtggcc cgagcagggc gatcagtgag cccggtgcga
    20761 cacccagcac ggactcgaga tgcccgagcg ccgccagcga ctcggctcgt tccggtctgc
    20821 gccgccccga ctgccagtag ctcagcgccg tcacgctgac cgacacgcca cgggcgcgta
    20881 accggtactg gatgcgatcg aggctgagcc cactggcctg gatggcggtg cgcagcgcgg
    20941 tcggaaaagc atcggccgcg aggctgtcca ccgggtgggg gagcgcacgc ctgatctcgc
    21001 cggttcggtg cagctctcga actggttcgc gggtcgcgcc gccacccatc gtggtctcct
    21061 cgcgttctcc ccagttgtcc ctacctacca cctggtaacc aacaccctac gacgtaccgg
    21121 ctggccgtgg tagccaacac gttaaatcca cgcgtgaccg tttcggtgct cacggtgatc
    21181 gtagcgccgg aaacctgctg gacggaacag tgccgccgtt ggctagcctc tatcagcaca
    21241 tcatccctcg acaggagaga gcacgccgtg atccgcacgc acgaggccgg gacgcttcgc
    21301 gccgaacacg ccggacagtc cgtcacgctg agcggctggg ttgcccgccg gcgcgatcac
    21361 ggtggggtca tcttcgtcga tctgcgtgac gcgtccggcg tcgcgcaggt ggtgttccgc
    21421 gaaggtgaga tggccgagcg cgcgcacggc ctgcgcgccg agtactgcat caaggtcgtc
    21481 ggcgaggtgg ccaagcggcc ccagggcaac gagaaccccg agatcgccac cggcgaggtc
    21541 gaggtcctgg tcacggagct gaccgtgctc agcgaggccg cgccgctgcc gttccagctc
    21601 gacgagcacc tcaccgtcgg cgaggacgtc cgcctccgcc accgctacct cgacctgcgc
    21661 cgcggcggcc ccgcgcgggc catgcgcatg cgcagcgagg ccaaccgcat cgccagggac
    21721 gtcctccacg ccgagaagtt cgtggaggtc gagaccccga cgctgacccg ctccaccccg
    21781 gaaggcgccc gcgacttcct ggtgcccgcc cgcctgcagc ccggctcctg gtacgcgctg
    21841 ccgcagtcgc cgcagctgtt caagcagctg ctgatggtcg gtggcctgga gcggtactac
    21901 cagatcgccc gctgctaccg ggacgaggac ttccgcgccg accgccagcc ggagttcacc
    21961 cagctcgaca tcgagatgag cttcgtcgag caggacgacg tgatcgcgct gggcga
//
