LOCUS       NZ_JACHJQ010000003     16667 bp    DNA     linear   CON 27-SEP-2024
DEFINITION  Actinophytocola algeriensis strain CECT 8960 Ga0436956_03, whole
            genome shotgun sequence.
ACCESSION   NZ_JACHJQ010000003
VERSION     NZ_JACHJQ010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinophytocola algeriensis
  ORGANISM  Actinophytocola algeriensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae.
REFERENCE   1  (bases 1 to 1136783)
  AUTHORS   Whitman,W.
  TITLE     Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the
            genomes of soil and plant-associated and newly described type
            strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1136783)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 154.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014203735.1-RS_2024_09_27
            Annotation Date                   :: 09/27/2024 05:42:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,095
            CDSs (total)                      :: 9,030
            Genes (coding)                    :: 8,881
            CDSs (with protein)               :: 8,881
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 23S)
            partial rRNAs                     :: 2, 2 (5S, 16S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 44 of 149
            Pseudo Genes (incomplete)         :: 120 of 149
            Pseudo Genes (internal stop)      :: 3 of 149
            Pseudo Genes (multiple problems)  :: 17 of 149
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:06:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 16667
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACHJQ010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..16667
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..16667
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..16667
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[178:6667](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(179..6667)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(34..51)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.19"
                     /tool="antismash"
     gene            complement(179..1297)
                     /locus_tag="FHR82_RS12230"
                     /old_locus_tag="FHR82_002497"
     CDS             complement(179..1297)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986483.1"
                     /locus_tag="FHR82_RS12230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002497"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_225944004.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.4e-12, bitscore:
                     43.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTMDPLEVAAGWVNGYEPLPMPEPGTPRTVLAELLRPHLRKSPC
                     LVAFSGGRDSSVLLAAAVALARREGLPLPTPITLSYPDAADTDESEWQQAVLTHLGLTH
                     RVVLTVHDEHDPLGPVATPILRRHGLIWPPNIAPTLRMLSMARGGTLLTGEGGDEAFGL
                     KRVTPLTKILKSRGRASPRVYADVPKALAPAALRRRSALRDRYRRPWLHPDVEADLARK
                     DAADLTAFSLHAGRNTWQFATRRSARIGYETVRALAAELDVTYVQAFAEPAMVAAVAAA
                     GGFLGWTGRAATMRSLFGDLLPREVLERRSKALFANAVFTRHTRDFARRWNGTGVDTDL
                     VNPEALRDNWLSPTPHAPSMSLLQQAWLAQRR"
     misc_feature    complement(260..262)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1238..1240)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1353..1493)
                     /locus_tag="FHR82_RS12235"
                     /old_locus_tag="FHR82_002498"
     CDS             complement(1353..1493)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986482.1"
                     /locus_tag="FHR82_RS12235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002498"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_184810512.1"
                     /transl_table=11
                     /translation="MRQPYEAPEITALGTLSDLTQANLFGQSSDNLTWILPILGDNDDY
                     S"
     misc_feature    1534..1549
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.5"
                     /tool="antismash"
     misc_feature    1554..1569
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.41"
                     /tool="antismash"
     gene            1604..3349
                     /locus_tag="FHR82_RS12240"
                     /old_locus_tag="FHR82_002499"
     CDS             1604..3349
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417453.1"
                     /locus_tag="FHR82_RS12240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002499"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_225944005.1"
                     /transl_table=11
                     /translation="MRRLVKTPRLIAAAAREVRRADRGGTLLATFYQLLGAVAALGVVA
                     AGKLTFDALLTPDHAAVGLTPALLLLALATAVSGSVGPLQTQQHRILGERVSQRVWDRL
                     LDTTARADLVTYESTGFATALERVRQHALTRPFAVTAALLGLTGSLLGVTAMSVVLLAV
                     EPLLLPLLLAAGIPAVLLARWASRTEFAFAHRLTALFRRRHYLQELLTQRPYAAEVRAF
                     DATGPLRARHDALNADVNAALSKQVRRRQLIAALTTLGVATALTGALLAIVQLVQTGRI
                     DLAEAGAAAIAVRLLSGQLGTLFGAIGGLLESAPFLADLERFVASGPEAGPRGHKHDLV
                     DRVSLRGARFSYPGLERPAVDGVDLEIRAGEVVALVGENGSGKTTLAKIVAGLYEPDDG
                     VRRWDGTAMPAPDVRASVTVIFQDFVRYQMTVRDNIVISGDGVDPEAAARSAGLLPTVR
                     GLPDGMDTMLGRDLDEGVDLSGGQWQRVALARALHRDTPLIVLDEPAAALDPRAEHELF
                     TNVRATLGGRAALLISHRFSSTRMADRIYVMDAGRVVECGTHDELMAAAGQYAELYRLQ
                     SAAYR"
     gene            3369..3743
                     /locus_tag="FHR82_RS12245"
                     /old_locus_tag="FHR82_002500"
     CDS             3369..3743
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHR82_RS12245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHR82_002500"
                     /product="hypothetical protein"
                     /protein_id="WP_184810514.1"
                     /transl_table=11
                     /translation="MRVTMGIAGGLILCVIGYLVYAAVVFWIKQPMGEPAPSAPYTART
                     LAGRLDFAMTDQEITDEAAKLEGSIVELHRKADETVVLVRVPAAEPGPTSDACYRFRLR
                     NGDVGHHVTGCPDTPPTSYR"
     gene            complement(3885..4100)
                     /locus_tag="FHR82_RS12250"
                     /old_locus_tag="FHR82_002501"
     CDS             complement(3885..4100)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHR82_RS12250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHR82_002501"
                     /product="hypothetical protein"
                     /protein_id="WP_184810515.1"
                     /transl_table=11
                     /translation="MTGLSVNSYVTIRDHCPMRYHVVDSDTVEFSFGGLRDPFEFVFDA
                     TALREFLRFGATALGEMDERGQASAE"
     gene            4160..4984
                     /locus_tag="FHR82_RS12255"
                     /old_locus_tag="FHR82_002502"
     CDS             4160..4984
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="FHR82_RS12255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002502"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_184810516.1"
                     /transl_table=11
                     /translation="MSRNDPRARDRIIGAKLRAIRTDRADISLERAAEMAGWAPSRLSR
                     TERGLRQVTIEEVATLLTAWRIPVREREGMLADVQAGSGSGWWDRSLPGVPSYTGALAS
                     YEADAIELVNVAVAVTPGLLQTYETAIAAMRADGVPEEDMETRWMVRLRRQQILGTVEY
                     SAYITESTLRTPFGGPKASRDQLEQLLVAQDRGMGVRVIPAHQTKVLLLHSWMWMAFPN
                     TKPVVHVELASGAFFLHDDDAARYTQMLDRLRRVALSRDDSRMLISGLMKEL"
     misc_feature    complement(4207..4225)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.31"
                     /tool="antismash"
     gene            4987..5142
                     /locus_tag="FHR82_RS12260"
                     /old_locus_tag="FHR82_002503"
     CDS             4987..5142
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="FHR82_RS12260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002503"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_184810517.1"
                     /transl_table=11
                     /translation="MWRKSSKSDSGGQCVEVRSDLGALRDSKQPGGPALVTPELGALIK
                     RLKSGQ"
     misc_feature    5104..5106
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5104..6012)
                     /locus_tag="FHR82_RS12265"
                     /old_locus_tag="FHR82_002504"
     CDS             complement(5104..6012)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986479.1"
                     /locus_tag="FHR82_RS12265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002504"
                     /product="hypothetical protein"
                     /protein_id="WP_184810518.1"
                     /transl_table=11
                     /translation="MNYHAYGLHIASDIPLPLPPGGGVPTLVLRRGEDREVPHERPQGE
                     RLAEVSRPDRTIFYTLARGPRTILRYPGLCDFEGDPKLEHVTVHLHPGADEGLLPVLIS
                     GAVLAVHLMLHHALVLHASAVDIGGSAVAFVGSSGMGKSTLAAALCGLGCSLVSDDLLR
                     VDGGMVHPGATENRLRENARELASGDTYETADGRLALRPTALVDAPLPLAACVVPRPSR
                     DVTEVALRRLGTAEALLRLSRYPRVLGWSDAASMATTFQGLGDLVERVPVFEAAIPWGP
                     PFADGVLADLLAALQPLDQSA"
     gene            complement(6009..6419)
                     /locus_tag="FHR82_RS12270"
                     /old_locus_tag="FHR82_002505"
     CDS             complement(6009..6419)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986478.1"
                     /locus_tag="FHR82_RS12270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002505"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_225944006.1"
                     /sec_met_domain="PF13471 (E-value: 7.2e-13, bitscore: 44.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRRARFALELLRALFWLTRIERGLRRSDLPAVCRLLGIACDVRS
                     AAPPATERAVLPRTTRTPVYACQYAVAHWPPGNTCLRRCLVLGRRLRHLGPVLRIGVRR
                     DESGEFVAHSWLEIDGRTLDPESARYATLGTA"
     gene            complement(6416..6667)
                     /locus_tag="FHR82_RS12275"
                     /old_locus_tag="FHR82_002506"
     CDS             complement(6416..6667)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986476.1"
                     /locus_tag="FHR82_RS12275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002506"
                     /product="PqqD family protein"
                     /protein_id="WP_184810519.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.1e-21,
                     bitscore: 72.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 5.6e-07,
                     bitscore: 25.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-16, bitscore: 56.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRTTDISARTIGGETIVLDLPNSQYFAITGVGSRVFELLGEDR
                     TLDDLVTTVVAEYEVDETTARRDVLAFVDRLHQARLLA"
     aSDomain        complement(6422..6649)
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FHR82_RS12275_Lasso_Fused_RRE.1"
                     /evalue="1.40E-08"
                     /identifier="RREFam003.1"
                     /label="FHR82_RS12275"
                     /locus_tag="FHR82_RS12275"
                     /protein_end="82"
                     /protein_start="6"
                     /score="25.7"
                     /tool="antismash"
                     /translation="DISARTIGGETIVLDLPNSQYFAITGVGSRVFELLGEDRTLDDLV
                     TTVVAEYEVDETTARRDVLAFVDRLHQARLL"
     aSDomain        complement(6422..6658)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FHR82_RS12275_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.90E-23"
                     /identifier="RREFam002.1"
                     /label="FHR82_RS12275"
                     /locus_tag="FHR82_RS12275"
                     /protein_end="82"
                     /protein_start="3"
                     /score="72.7"
                     /tool="antismash"
                     /translation="RTTDISARTIGGETIVLDLPNSQYFAITGVGSRVFELLGEDRTLD
                     DLVTTVVAEYEVDETTARRDVLAFVDRLHQARLL"
     misc_feature    complement(6731..6746)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.85"
                     /tool="antismash"
     misc_feature    6806..6819
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.13"
                     /tool="antismash"
     gene            6819..7481
                     /locus_tag="FHR82_RS12280"
                     /old_locus_tag="FHR82_002507"
     CDS             6819..7481
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013718.5"
                     /locus_tag="FHR82_RS12280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002507"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_184810520.1"
                     /transl_table=11
                     /translation="MSVLAAIALVVMGFVFAGQSAGAAVDIGVREELRQLGSTWRQLAL
                     AVDWLAEPVGAVVVLGTCVLLFLRARNRFAAVLVVVAPAAVVVVTTGMKPLTGRTINDG
                     FLAFPSGHTAFLAAVALVVTLSVARRLVVVMVVTLAAGLAMAWAQVLLNAHYPTDTLGG
                     FCVTLAVVPVVVLALDRIWTVASRAAPAAADDRPDGNPLPARGGAPAVPPSPSATHD"
     gene            complement(7600..8241)
                     /locus_tag="FHR82_RS12285"
                     /old_locus_tag="FHR82_002508"
     CDS             complement(7600..8241)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018682907.1"
                     /locus_tag="FHR82_RS12285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002508"
                     /product="response regulator transcription factor"
                     /protein_id="WP_184810521.1"
                     /transl_table=11
                     /translation="MINVVVVDDHPVVVAGVRAWCADADPPIQVVASGPTVATAWVGPG
                     AEADVVVLDLQLDMTGPAYGELKRLVDAGRTVVVSTMRDDQETALTCLDIGAFTYLTKA
                     EGESHLVAAIHAAARHEPYTPPALAGALGTDTNPNRPRLSEQEVNVLREWFHCESKKSV
                     ADALNITVNTVNTYLTRVRAKYASAGRAAPTKAALVARALQDGLVTIDEL"
     gene            complement(8238..10475)
                     /locus_tag="FHR82_RS12290"
                     /old_locus_tag="FHR82_002509"
     CDS             complement(8238..10475)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="FHR82_RS12290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002509"
                     /product="ATP-binding protein"
                     /protein_id="WP_184810522.1"
                     /transl_table=11
                     /translation="MGGELGSTERELLRAGARYAVGLRALMSAVAGMVSIALETTAAPV
                     LTVFVVIGLVAWTVYYAHQFPRRGRLLVPLDVTIVCAVCLTQLWTVPTGSAHGITWVIA
                     VIGITVIAYAWQLSLVAHAAATLTVMAAFLVGAMIADSPGWLDVLPLQLWTVVEGGLSR
                     ALYLLVRRGARDADRAVARSEQARRDAAVAEARRADEREYLAALHDTASATLLMVGSGV
                     TGRRTEWLSAQAARDLDAISGDHASPAGEVDLVAHLRDVARHLPLTVHWDAPGFVTVPA
                     ADAVALAGGVREALTNVVRHAGVGEARVHVRRDDDSVVVEVADEGTGFDPARVNGHRYG
                     VTRSIVERLTRAGGSAEVISRPGNGTRVRLTRPFAISTDTAGDVETIKSGVDTALRWSV
                     VVMNLIILFGLDLPRLVANQEHYSSLATQVLTLVVLTAVTLVVAWHLWRKRPLGLLRWP
                     LVAVVFVISALCTEAVPPGLRLGLAHWSEGDAAWTLLLLVLDYRVAVMAVLLAAHYAMT
                     FTQTALGGDAAITVAEAVNATVVVFSYQLAVGVVTVVLRPVAITAAAVTYREERLRTER
                     AVAEQVHRDRTERYAALADSTAPLLAALASGEADPGDPVFRRACAVEAGRVRRLLAEDT
                     SVPDQLSHELRACVELAERNGITVHFAERGERPQVPKSVRRALTDPAVAALATAASTAR
                     VTVVGAADEVTVSVVADAPAELVPMNSDPAIKVTAADNGGKLWIKTTWRRT"
     misc_feature    10502..10517
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     gene            complement(10626..11921)
                     /locus_tag="FHR82_RS12295"
                     /old_locus_tag="FHR82_002510"
     CDS             complement(10626..11921)
                     /EC_number="5.4.3.8"
                     /NRPS_PKS="Domain: Aminotran_3 (39-333). E-value: 1.4e-43.
                     Score: 141.1. Matches aSDomain:
                     nrpspksdomains_FHR82_RS12295_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018334262.1"
                     /locus_tag="FHR82_RS12295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002510"
                     /product="glutamate-1-semialdehyde 2,1-aminomutase"
                     /protein_id="WP_184810523.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.6e-39, bitscore:
                     130.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTRSREANKNLHDMVPGGSHTYAKGEDQYPEGMAPVFVRGQGA
                     HVWDVDGNEFIEYGSGLRAVSLGHAHPRVVSAVRAQLALGGNFVRPAALEVEAAAKFLA
                     TVPTAEMVKFAKNGSDVTTAAVRLARAATGRTTIALCADQPFFSTDDWFIGTTAMSAGI
                     PAQDVVSFPYGDLAAVEQLFTSHEVACLVLEAATQTDPPPGYLRGLRDLCTRHGVVLVF
                     DEMITGFRWSEAGAQGLYGVTPDLSTFGKALGNGFAVSALAGRRDLMELGGLRDSRERV
                     FLLSTTHGGETHSLAAAMAVMDTYVEEGIADRLHAIGARLAAGVREVAAAAGVGEHVVV
                     RGRDCNLVFATLDVDGRPSQEYRTLFLRRLILGGVVGPSFVVSSALTDADLDRTVEVVA
                     DACAVYRQALDAGDPSPWLGGRPVKPVFRPFA"
     aSDomain        complement(10923..11804)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHR82_RS12295_Aminotran_3.1"
                     /evalue="1.40E-43"
                     /label="FHR82_RS12295_Aminotran_3.1"
                     /locus_tag="FHR82_RS12295"
                     /protein_end="333"
                     /protein_start="39"
                     /score="141.1"
                     /tool="antismash"
                     /translation="VRGQGAHVWDVDGNEFIEYGSGLRAVSLGHAHPRVVSAVRAQLAL
                     GGNFVRPAALEVEAAAKFLATVPTAEMVKFAKNGSDVTTAAVRLARAATGRTTIALCAD
                     QPFFSTDDWFIGTTAMSAGIPAQDVVSFPYGDLAAVEQLFTSHEVACLVLEAATQTDPP
                     PGYLRGLRDLCTRHGVVLVFDEMITGFRWSEAGAQGLYGVTPDLSTFGKALGNGFAVSA
                     LAGRRDLMELGGLRDSRERVFLLSTTHGGETHSLAAAMAVMDTYVEEGIADRLHAIGAR
                     LAAGVREVAAAAG"
     gene            complement(11928..12473)
                     /locus_tag="FHR82_RS12300"
                     /old_locus_tag="FHR82_002511"
     CDS             complement(11928..12473)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030957.1"
                     /locus_tag="FHR82_RS12300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002511"
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase family
                     protein"
                     /protein_id="WP_184810524.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 5.7e-54,
                     bitscore: 178.4, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIPVPEIAGAYVFEPSPHADERGFFCRTFDAEVVRSAGIDPDG
                     FAQDSVSRSARGVLRGMHLRSGRGEAKLVRCSYGRVFDVIVDLRPDSPTFRNQKHLELS
                     GDTQVTLYVPAGCAHGFQALTDPADVSYRIDRPHDPAEDVAIAFDDPELAIPWPLPPAL
                     LSQRDRQAPTLAAALGRT"
     misc_feature    12469..12484
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.89"
                     /tool="antismash"
     gene            complement(12475..13257)
                     /locus_tag="FHR82_RS12305"
                     /old_locus_tag="FHR82_002512"
     CDS             complement(12475..13257)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020629995.1"
                     /locus_tag="FHR82_RS12305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002512"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_311771034.1"
                     /transl_table=11
                     /translation="MRQAGSRAEDLVQRVLTRVGLSQSESRIAADAQDYWASTGSASWK
                     ANSHWRGAHVFDDGDLWHEIGKRHLEMFDRGARGVGFDRPLGRVVEWGCGGGANAVHFA
                     PRAAEFVGVDVVPETLEECARQVTAHCDTPFTPVLAEVTRPERVVEEIGTCDLFLCFYL
                     FELIPTPEYGERLLRIASRVLAPGGLALIQVKYHEGDFWTRPRRRGYRTSVAGMTTYSV
                     PEFWQLVAKCGLRPENVVLVPENELDRRYAYFLASKGE"
     gene            complement(13317..14516)
                     /locus_tag="FHR82_RS12310"
                     /old_locus_tag="FHR82_002513"
     CDS             complement(13317..14516)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986472.1"
                     /locus_tag="FHR82_RS12310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002513"
                     /product="polysaccharide pyruvyl transferase family
                     protein"
                     /protein_id="WP_311771035.1"
                     /transl_table=11
                     /translation="MKVGLFGLLGAGNMGNDGSLEVVLAYLREHHPSAELSALASGPDV
                     VEARYGVPAVPLYSYYTRDRDSGLPARVVLKSVAKFRDAAQVWRWVRRNDVVIVPGAGV
                     LENTLPLRAWGFPLSLFLLSFFGRLTGTKVAFVNVGSNVIRQRAMRFFIRWATRLAHYR
                     SFRDSLSRDALATMGVDTARDEIFPDLVFALPAPEVTVERGTVAVGLMDFHGSNDDRAS
                     AEAIHRTYVDGMRRFVRWLVDGGHRVRLLIGDEVDEAIVEQVLADSKDRPGAVTYETIR
                     TLGDVMAQIAKSEVVVGTRYHNVLCGLKLAKPTISVSYSAKNDRIMADMGLAEYTQDAR
                     TVDVDRLVEQFTAVEAAADRIGPMLGEHAARKSARLARQFEVLSASLGMPAEVTQEVGS
                     "
     gene            complement(14513..15445)
                     /locus_tag="FHR82_RS12315"
                     /old_locus_tag="FHR82_002514"
     CDS             complement(14513..15445)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986471.1"
                     /locus_tag="FHR82_RS12315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002514"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_184810526.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.6e-28,
                     bitscore: 95.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPRLTIGLPVYNGEEYLAESLDALLGQSFEDYELIITDNASTDG
                     TAGICKRYLKADSRISYHRLPRNIGAAGNHNHVFTLASGELFKWASHDDLYGRTLLERC
                     VEFLDDNPDFVLAHSYNATIDSHGKIIEPYDYRIPTDSPSAAERFRGLLHAPGGDDFYG
                     VIRTADLRRVKPHDSYHHADRTFVMDMAMQGRFHQVAELLYFRRDHENRAERANPSIRS
                     RCANLDPKRATGFNPAPRLLAEYALGYVGLIRRAPISAAEKRTCYRHLAEYLSSRVTRK
                     VVSADSRPAVAPKNQVLSIDGIVPRGAHR"
     gene            complement(15442..16644)
                     /locus_tag="FHR82_RS12320"
                     /old_locus_tag="FHR82_002515"
     CDS             complement(15442..16644)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633240.1"
                     /locus_tag="FHR82_RS12320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHR82_002515"
                     /product="hypothetical protein"
                     /protein_id="WP_225944901.1"
                     /transl_table=11
                     /translation="MTNFVVGVFVARELGVAAFGIFSLAWVTYGVVLNVSRGLATDPLV
                     VRFSGVSTADWRHATSRAAGTAIAVGAAFGVVSALAGFAMGGTLGDAFVALAVVAPGML
                     LQDSWRFAFFAAGAGHKAFVNDVVWAVTMIPLLLLASLHGTVWGFVLAWGGASLLAAGC
                     GWLQSGITPHFSGIRDWLHAHRDLGSRYLVENVSNSGASQLRMYGLGAIAGLADVGAIR
                     GAELLLGPFLALLMGLNLVAVPEAARVLRRAPGRLARFCLTLGGVQAVAAATWGVILLF
                     LVPDALGRLVLDDVWTHAQPLILPVSLSVTGAGVVAGAAAGLRALGAARRSLRAQLVAS
                     SGYLGFGLAGAWLGGAVGMSWGSTTAMWLGAGLWWLQLRAALREHTPEPELPNLAESRT
                     S"
ORIGIN
        1 aaccggcacc cactacaacg aaaccaccgc ctggtcacac cacaccaaca acattgcggc
       61 ttgacacacc agcacctggg atgtctttca cggcacacca gccccgtccc ggcacgggcg
      121 atcaccgtcg gctggccgga cccgccgcag gacccggcaa acgttggtgg acacagcgct
      181 agcggcgctg ggccagccag gcctgttgca gtagcgacat cgacggcgcg tgcggtgtgg
      241 gtgacaacca gttgtcgcgt aacgcttccg ggttcaccag gtcggtgtcg acgccggtgc
      301 cgttccacct gcgggcgaag tcccgggtgt ggcgggtgaa gaccgcgttc gcgaacaggg
      361 ccttcgagcg gcgttccagt acttcgcggg ggaggaggtc gccgaacagg gagcgcatgg
      421 tcgccgctct gccggtccag cccaggaatc cgcctgccgc ggccaccgca gccaccatgg
      481 cgggttccgc gaaggcctgt acgtacgtca cgtccagttc cgcagccagg gcccgcaccg
      541 tctcgtagcc gatccgcgcg ctgcggcgag tggcgaactg ccacgtgttg cggcccgcgt
      601 gcagggagaa cgccgtcagg tctgccgcgt ccttgcgggc caggtcggct tccacgtccg
      661 ggtgcagcca cggtctccgg tagcggtccc gcagcgccga tcgtctgcgc agtgccgcgg
      721 gggccagtgc tttcggcacg tccgcgtaga cccgcgggga ggctcgtccc cttgacttca
      781 ggatctttgt cagtggggtc acgcgtttca ggccgaacgc ctcgtcgccg ccttcgcccg
      841 tgaggagggt gccaccccgt gccatcgaca gcatgcggag ggtcggggcg atgttcgggg
      901 gccagatcag gccgtggcgt ctcagtatgg gggtggccac cgggcccagt gggtcgtgct
      961 cgtcgtggac tgtcaggacc acgcggtggg tcaggccgag gtgggtcagt accgcctgtt
     1021 gccactccga ctcgtcggtg tcggcggcgt ccgggtagga cagtgtgatc ggggtgggca
     1081 gcgggaggcc ttccctgcgg gccagtgcca ccgcggctgc cagcagtacc gacgagtcac
     1141 ggccgcccga gaacgccacc aggcacgggg acttccgcag gtgaggtcgc agcagctcgg
     1201 ccaggaccgt cctcggggtg cctggctcgg gcatgggtaa cggctcgtag ccgttcaccc
     1261 agcctgccgc cacctccagc gggtccattg tgtacatcga gctgctcctt cgagtggtga
     1321 cgggtccggc gcaggacccg tcaccaaccg gctcacgagt agtcgtcgtt gtcgccgagg
     1381 atcgggagga tccacgtcag gttgtcgctg gactgtccga acaggtttgc ctgggtcagg
     1441 tccgacaacg tccccagtgc ggtgatctcc ggcgcttcgt aaggctggcg catgctttca
     1501 cctcctcatg gtgtgactgg tacgtcgtcg atctctgcga ttcattacct accgggacgg
     1561 tctggtcggt aacgaaagct gtacgtaatc ggacctaatg aacatgcgcc ggttggtgaa
     1621 gaccccacga ctgatcgccg ccgccgcacg ggaggtgcgg cgggccgaca ggggtggcac
     1681 cctgctcgcg accttctacc agctgctggg agccgttgcg gcgcttggtg ttgtggcggc
     1741 agggaagttg accttcgacg ctctgctcac gcccgatcac gcggcggtcg gtctcacccc
     1801 ggctctgttg ctgctggcgc tcgccaccgc cgtctccggg tccgtcggtc cactccagac
     1861 acagcagcac cgcatcctcg gcgagcgggt gtcacagcgc gtgtgggacc ggttgctcga
     1921 caccaccgcg cgtgccgatc tcgtcaccta cgagtcgacc ggtttcgcca cggcactcga
     1981 acgggtacga cagcacgcac tcacgcgacc cttcgccgtc accgccgcgt tgctggggct
     2041 caccgggagc cttctcgggg tgacggccat gtccgtcgtg ctactggcag ttgagccgct
     2101 actcctgccg ctgctgctcg ccgcggggat tcccgctgtc ctgctcgcac ggtgggccag
     2161 tcgtaccgag ttcgcgttcg cccatcggct caccgccttg ttccggcggc ggcactacct
     2221 ccaggagctg ctcacccagc ggccctacgc ggccgaggtg cgcgccttcg acgcgacggg
     2281 cccgctgcgg gccaggcacg acgcgctcaa cgccgacgtg aacgcggccc tgagcaagca
     2341 ggtccggcgc aggcaactga tcgccgcgct cacgacgttg ggggtggcga ccgccctgac
     2401 cggcgccctg ctggcgattg tccaactggt acagaccggg cgcatcgacc tcgccgaggc
     2461 cggggccgcc gcgatcgccg tgcgcctgct cagcgggcag cttggcacgt tgttcggagc
     2521 catcggcgga ctcctcgagt cggcgccgtt cctcgcggac ctggaacggt tcgtcgcgag
     2581 tggacccgag gccgggcctc gcggacacaa gcacgacctc gtcgaccggg tgtcgttgcg
     2641 gggtgcgcgg ttcagctacc cgggactgga gcggcccgcg gtcgacggtg tcgacctgga
     2701 gatccgcgcc ggtgaggtcg tcgcgctcgt cggcgagaac gggtccggca agacgaccct
     2761 cgccaagatc gtcgcgggac tgtacgagcc cgacgacggc gtgcgccgct gggacgggac
     2821 cgccatgcca gcgcccgacg tgcgtgcctc cgtcaccgtg atcttccagg acttcgtgcg
     2881 gtaccagatg accgtgcgcg acaacatcgt catcagcggc gacggtgtcg accccgaggc
     2941 cgccgcgcgg tccgccgggc tgctgccgac cgtgcgcggg ttgccggacg gcatggacac
     3001 catgctcggc cgcgatctcg acgagggcgt cgacctgtcc ggtgggcagt ggcagcgggt
     3061 cgcgctcgcc agggcgctgc accgggacac gccgctgatc gtgctggacg agcccgctgc
     3121 cgcgctggac ccgcgtgccg agcacgagct gttcaccaac gtgcgggcca cgctgggcgg
     3181 gcgagccgct ttgttgatct cgcaccggtt ctcgagcacg cggatggccg accggatcta
     3241 cgtcatggac gcggggcggg tcgtggagtg cggcacgcac gacgagctga tggccgccgc
     3301 cgggcagtat gctgagctgt accggctgca gtcggcggcc taccgctgat cgccatgtgg
     3361 gggcactgat gcgcgtgacg atggggatcg cggggggcct catcctttgt gtgatcggct
     3421 acctggtgta tgccgccgtg gtgttctgga tcaaacagcc gatgggcgag ccggccccat
     3481 ccgcgccgta cacggcgcga acgctggcag gacgactcga cttcgccatg accgaccagg
     3541 agatcaccga tgaggcggcc aagctggaag ggtcgatcgt cgagctccac cgcaaggctg
     3601 acgaaacggt cgtgctcgtc cgggttcccg ccgcagagcc cggaccgact tcggacgcct
     3661 gctatcggtt ccgactgcga aacggcgacg tcggccacca tgtaacggga tgcccggaca
     3721 cgccaccgac ctcctatcgc tgacgttcga tcggtagcca gacctccagg cacggccagc
     3781 ccacgccgca cgcgaggcac aggcccgagc gttcgcccgg gcggtgttcg cggagggtgt
     3841 ggacgaggag ttcgtactgg gcggtcgctt ccaggacgcc ggactcactc cgccgatgcc
     3901 tgcccacgct cgtccatctc ccccagggcg gtcgcgccga agcgcaggaa ctcgcggagc
     3961 gcggtggcgt cgaagacgaa ctcgaacggg tcgcgcaggc cgccgaagga gaactcgacg
     4021 gtgtcgctgt ccacgacgtg gtagcgcatg gggcagtggt ctcgaatggt gacgtaggaa
     4081 ttcacgctca ggcctgtcat gcgatcagac gctacgcttc ttcgggaccc aacagatcga
     4141 attgccaggg gtgacaggaa tgagtaggaa cgacccgcgt gcgcgtgacc gcatcatcgg
     4201 agcaaaactg cgggccattc gcacggaccg ggcggatatt tcactcgaac gtgctgccga
     4261 gatggccggc tgggcgccca gccggctcag ccggaccgag cgcggactgc ggcaggtgac
     4321 tatcgaggag gtggcgactc tccttaccgc atggcggatt cctgtcagag aaagggaggg
     4381 gatgctggca gacgttcagg ccggatccgg atcggggtgg tgggatcgct cgctgccggg
     4441 cgttccgagc tacacggggg cgttggcgag ttacgaggcc gacgcgattg agttggtgaa
     4501 cgttgccgtc gcggttactc cgggtctgtt gcaaacctat gagacggcga tcgcggcaat
     4561 gcgcgccgac ggtgttccgg aggaggatat ggagacgcgc tggatggttc gcctgcggag
     4621 gcagcagatt ctcggcacag tcgaatattc ggcctacatc accgagtcga cgttgcggac
     4681 gccattcggc ggtccgaagg cgtcgcggga ccagttggag caacttcttg tcgcacagga
     4741 cagggggatg ggggtgcggg tgatccccgc gcaccagacg aaggtcctgc ttctgcattc
     4801 gtggatgtgg atggcgttcc cgaacacgaa gccggtagtt cacgtcgagc tggcctcggg
     4861 ggcgttcttc ctccacgacg atgatgcggc gcgctacacg cagatgttgg atcggctgcg
     4921 aagggtggcc ctgtcgcggg acgacagccg tatgctgatc agtggtctga tgaaggagtt
     4981 gtgagcatgt ggcgtaagtc gagcaagagc gactcgggtg gccagtgtgt tgaggttcgg
     5041 tcggatcttg gggcgttgcg ggacagcaag cagcccggcg ggcctgcgct ggtcacgccg
     5101 gagttaggcg ctctgatcaa gcggttgaag agcggccagt aggtccgcca gcacgccgtc
     5161 cgcgaagggc gggccccacg ggatcgccgc ttcgaagacc ggcacccgct ccaccaggtc
     5221 ccccagtccc tggaacgtcg tggccatcga cgccgcgtcg ctccagccca gcaccctcgg
     5281 gtagcggctc aggcgcagca acgcttccgc cgtgcccagg cgcctcaacg ccacctccgt
     5341 gacgtctcgg cttggccttg ggactacgca cgctgccagc gggagcgggg cgtcgaccag
     5401 cgctgtcggg cgtagggcca ggcggccgtc ggctgtctcg tacgtgtcgc cgctggcgag
     5461 ttcgcgggcg ttctcgcgga ggcggttctc ggtggcgccc gggtggacca ttccgccgtc
     5521 cacgcgcagg aggtcgtcgg agaccaggct gcagcccagg ccgcacaggg cggcggcgag
     5581 ggtcgacttg cccatgcccg acgagccgac gaacgccacc gccgagccgc cgatgtccac
     5641 cgcgctggcg tgcaggacca gtgcgtggtg gagcatcagg tgcacggcca gcacggcacc
     5701 ggagatcagg accgggagca ggccttcgtc ggcgcccggg tgcaggtgca ccgtgacgtg
     5761 ttcgagcttc gggtcgccct cgaagtcgca gaggcccggg tagcggagga tcgtccgggg
     5821 gcctctcgcg agggtgtaga agatcgtgcg gtccgggcgg gagacctctg ccagccgctc
     5881 gccttgggga cgctcgtgcg ggacctcccg gtcctcgcct cggcgcagga ccagggtcgg
     5941 gacgccgccg ccgggtggga gcggcagggg gatgtcgctg gcgatgtgga ggccgtaggc
     6001 gtggtagttc atgccgtccc cagggtcgcg tagcgggccg actcggggtc gagggtccgg
     6061 ccgtcgatct ccagccagga gtgggccacg aactcgccgc tctcgtcccg gcggacgccg
     6121 atgcgcagca ccgggcccag gtggcgcagg cgccggccca ggaccaggca gcggcgcagg
     6181 cacgtgttcc ccggcggcca gtgggcgacc gcgtactggc aggcgtacac cggggttctg
     6241 gtggtgcggg gcagtaccgc gcgctcggtc gccggtgggg cggcgctgcg gacgtcgcag
     6301 gcgatgccga gcaggcggca gaccgccggg aggtcgctgc ggcgcagacc ccgttcgatg
     6361 cgggtcagcc agaacaacgc tctcagcagc tccagtgcga accgtgcccg tcgcctcatg
     6421 ccagcagccg cgcctggtgc agccggtcga cgaacgccag cacgtcgcgg cgggcggtgg
     6481 tctcgtcgac ctcgtactcg gcgacgactg tcgtgaccag gtcgtcgagg gtgcggtcct
     6541 cgcccagcag ctcgaacacc cggctgccga cgcccgtgat ggcgaaatac tgggagttgg
     6601 gcaggtcgag gacgatcgtc tcgccgccga tggtgcgtgc ggagatgtct gtggtgcgca
     6661 gtcgcatagc ggttttcccc ttccgcgctc cactgtggat tcggaccggc gtggcgggtc
     6721 gttacctggt gcgaaacaat cgtgaccgct tcgacgattt cccttgcgtg cgggtcgaat
     6781 caggggcgcg tgcgcgagtc ggtccgtcac tcggcgtgat gtccgtgctc gcggcgattg
     6841 ccttggtggt catgggtttc gtgttcgccg gtcagtccgc gggggcggcc gtcgacatcg
     6901 gcgtgcggga ggagttgcgg cagctcgggt cgacgtggcg gcagctcgcg ctggccgtcg
     6961 actggctcgc cgaaccggtg ggcgccgtcg tcgtgctcgg cacgtgcgtg ctcttgttcc
     7021 tgcgtgcgcg caaccggttc gccgcggtgc tggtggtggt cgcgcccgcc gcggtcgtcg
     7081 tggtgaccac cggcatgaaa ccgttgacag gacggacgat caacgacggg ttcctggcgt
     7141 tccccagcgg gcacacggct ttcctggccg ctgtcgcgct ggtcgtgaca ctgtccgtgg
     7201 cgcggcggct cgtggtggtc atggtggtga ccctggctgc cgggctggcg atggcgtggg
     7261 cgcaggtgct gctcaacgcg cactacccga ccgacacgct cggcgggttc tgcgtcacgc
     7321 tcgccgtggt gcccgtcgtg gtgctcgccc tggacaggat ttggacggtc gccagccgcg
     7381 ctgcccctgc tgcggcggac gaccgtcctg acgggaaccc tctccctgcg cgcggcggcg
     7441 caccagccgt gccgccgtca ccgagtgcta cccacgactg accatgggcg gtctcgccgt
     7501 tgcctgtgga gctgggtgct gaccctcggt gccacgcttg tttcccgctg tgtccacggt
     7561 agggcgaatc gtgcctcgtg aatgagacac gttcgtacct catagctcgt cgatcgtcac
     7621 cagaccgtcc tggagggccc gcgcgaccag cgcggccttc gtcggggcgg cgcggcccgc
     7681 gctcgcgtac ttggcccgca ccctggtcag ataggtgttc acggtgttga ccgtgatgtt
     7741 cagcgcgtcc gcgaccgact tcttggactc acagtggaac cactcgcgca ggacgttgac
     7801 ctcctgctcg gagagccgcg ggcggttcgg gttcgtgtcg gtgccgagcg cgccggccag
     7861 ggcgggcggc gtgtaaggct cgtggcgggc ggccgcgtgg atcgcggcga ccaggtgcga
     7921 ctcgccctcg gccttggtga ggtaggtgaa cgcgccgatg tcgagacagg tcagcgcggt
     7981 ctcctggtcg tcgcgcatgg tgctgaccac gaccgtgcgg ccggcgtcga cgaggcgttt
     8041 cagctcgccg taggccggac cggtcatgtc gagctgcagg tccagcacga ccacgtccgc
     8101 ctcggcgccc gggccgaccc acgcggtcgc gaccgtcggg cccgacgcca ccacctggat
     8161 cggcgggtcg gcgtccgcgc accacgcccg cacacccgcg accaccaccg ggtggtcgtc
     8221 caccaccact acgttgatca tgttcgccgc caggtcgtct tgatccacag cttgcccccg
     8281 ttgtccgcgg cggtcacctt gatggccggg tcactgttca tcggcaccag ctccgcgggc
     8341 gcgtccgcga ccaccgacac cgtgacctcg tcggcggcgc cgacgaccgt caccctggcg
     8401 gtgctggccg ccgtcgccag cgcggccacg gccgggtcgg tcagggcgcg gcgcacggac
     8461 ttcgggacct gcggccgttc gccgcgctcg gcgaagtgga cagtgatccc gttgcgctcg
     8521 gccagttcca cgcacgcccg cagctcgtgt gacagctggt ctggcacgct cgtgtcctcc
     8581 gcgaggagcc gccgcacccg tcccgcctcc accgcgcacg cccgccggaa caccgggtcg
     8641 cccgggtccg cctcgccgga cgccagcgcg gcgagcagcg gggcggtcga gtcggccagg
     8701 gcggcgtagc gctcggtgcg gtcgcggtgg acctgttcgg ccaccgcgcg ttcggtgcgc
     8761 aggcgttcct cccggtacgt gacggcggcg gcggtgatcg cgaccggccg cagcacgacg
     8821 gtgaccacgc caaccgccag ctggtagctg aacacgacga ccgtggcgtt gaccgcttcg
     8881 gcgacggtga tggccgcgtc gccgccgagg gcggtctgcg tgaacgtcat ggcgtagtgg
     8941 gcggcgagga gcacggccat caccgcgacg cggtagtcca ggaccagcag caggagcgtc
     9001 caggccgcgt cgccctccga ccagtgggcc aggccgagac gcaggccggg cggcacggcc
     9061 tcggtgcaca gcgccgagat cacgaacacg acggccacca gcggccagcg caggagaccg
     9121 agcgggcgtt tgcgccacag gtgccacgcg accacgagcg tcacggcggt gagcaccacg
     9181 agggtcagga cctgtgtggc cagtgagctg tagtgctcct ggttggcgac gaggcggggc
     9241 aggtcgaggc cgaacaggat gatcaggttc atcacgacga ccgaccagcg cagcgcggtg
     9301 tcgacgccgg acttgatcgt ctcgacgtcg cccgcggtgt cggtcgagat cgcgaacggg
     9361 cgggtcaggc ggacgcgggt gccgttgccg gggcggctga tcacctcggc ggaaccaccc
     9421 gcgcgggtga ggcgttcgac gatggagcgg gtcacgccgt agcggtgacc gttgacgcgg
     9481 gccgggtcga agccggtgcc ctcgtcggcg acctccacga cgacgctgtc gtcatcgcgc
     9541 cgcacgtgga ccctggcctc gccgactccc gcgtgccgca cgacgttcgt cagcgcttcg
     9601 cggacgccgc ccgcgagcgc gacggcgtcg gcggccggga cggtcacgaa gccgggggcg
     9661 tcccagtgga cggtgagcgg gaggtggcgg gccacgtccc ggaggtgtgc gaccaggtcc
     9721 acctcaccgg ccggggaggc gtggtcgccg ctgatggcgt cgaggtcgcg ggcggcctgt
     9781 gcggacagcc actcggtgcg cctgcccgtg acgccggagc cgaccatgag cagcgtcgcg
     9841 gacgcggtgt cgtggagggc ggcgaggtac tcgcgttcgt cggcgcggcg ggcctcggcg
     9901 acggcggcgt cccggcgggc ctgctcactg cgggcgacgg cccggtcggc gtcccgggca
     9961 ccccggcgga cgagcaggta cagcgcccgc gacagcccgc cctcgacgac cgtccacagt
    10021 tgcagcggca gcacgtcgag ccagcccggc gagtcggcga tcatcgcgcc gacgaggaag
    10081 gcggccatga cggtcagggt cgcggccgcg tgcgcgacga gcgacagctg ccacgcgtag
    10141 gcgatgacgg tgatgccgat gaccgcgatg acccaggtga tgccgtgggc cgaaccggtc
    10201 ggcaccgtcc acagctgagt caggcagacc gcgcagacga tggtcacgtc caacggcacg
    10261 agcaggcggc cgcggcgcgg gaattggtgg gcgtagtaga cggtccaggc gaccaggccg
    10321 atcacgacga agaccgtgag gacgggcgcc gcggtcgtct cgagcgcgat ggacaccatg
    10381 ccggcgaccg cggacatgag cgcccgcagc ccgaccgcgt accgggcacc ggcgcgcagc
    10441 agttcccgct cggtgctgcc caactccccg cccacgcgcc accgccttgc cggagggatg
    10501 cgtcaccggc atgttaccca gcgcggtgat cttccagccg cgcatccggg tgatgctcag
    10561 cgcgatgaag gacccctccg tcacgctgag cataaggaag gggtccttcg taacaccggg
    10621 tgcgatcagg cgaacgggcg gaacaccggc ttcacgggac ggccaccgag ccacggcgac
    10681 gggtcacccg cgtccagcgc ctggcggtac accgcgcagg cgtcggccac gacctcgacc
    10741 gtgcggtcca ggtcggcgtc cgtgagggcg ctgctgacca cgaacgacgg gccgaccaca
    10801 ccacccagga tcagcctgcg caggaacagc gtccggtact cctgagacgg cctgccgtca
    10861 acgtcgaggg tcgcgaagac caggttgcag tcgcggccgc ggaccaccac gtgctcgccg
    10921 accccggccg ccgccgccac ctcgcgcacc ccggcggcga ggcgggcacc gatggcgtgg
    10981 aggcggtccg cgatgccctc ctccacatag gtgtccatga cggccatcgc ggcggcgagc
    11041 gagtgggtct cgccgccgtg ggtggtggac aggaggaaga cgcgttcgcg ggagtcgcgc
    11101 aggccgccca gttccatcag gtcgcgcctg cctgccagcg ccgacacagc gaacccgttg
    11161 ccgagcgcct tgccgaacgt cgacaggtcc ggggtcacgc cgtacagacc ctgcgcgccc
    11221 gcctccgacc agcggaagcc ggtgatcatc tcgtcgaaga ccagcacgac accgtgacgg
    11281 gtgcacagat cgcgcaggcc ccgcaggtat ccgggtggcg ggtcggtctg cgtggcggcc
    11341 tcgagcacca ggcacgcgac ctcgtgcgag gtgaacagct gctcgactgc ggcgagatcg
    11401 ccgtatggga acgagacgac gtcctgtgcc gggatgccgg cggacatcgc ggtggtgccg
    11461 atgaaccagt cgtccgtgga gaagaacggc tggtccgcgc acagcgcgat cgtggtgcgc
    11521 ccggtcgcgg cacgcgcgag gcggaccgcc gcggtcgtga cgtccgagcc gttcttggcg
    11581 aacttgacca tctccgcggt aggcacggtc gcgaggaact tcgcggccgc ctcgacctcc
    11641 agcgcggccg gccgcacgaa gttgccgccc agtgccaact gcgcgcgcac agccgagaca
    11701 acgcgagggt gtgcgtgccc gaggctcacc gcacgcagtc cggagccgta ctcgatgaac
    11761 tcgttcccgt cgacgtccca cacgtgcgcg ccctgaccgc ggacgaacac cggggccatg
    11821 ccctccgggt actggtcctc acccttggcg taggtgtggc taccgccggg caccatgtcg
    11881 tggaggttct tgttcgcctc gcgggaacgg gtgaagtcca tcggtcctta cgtccttccg
    11941 agtgccgccg ccagtgtcgg cgcctgccgg tcccgctgcg acaacagcgc gggcggcaac
    12001 ggccacggga tcgccagctc ggggtcgtcg aaggcgatcg ccacgtcctc cgccgggtcg
    12061 tgcggccgat cgatgcgata ggacacgtcg gcggggtcgg tgagcgcctg gaacccgtgc
    12121 gcgcaaccgg cgggcacgta cagcgtcacc tgtgtatcgc cggaaagctc cagatgtttc
    12181 tggttccgga aggtgggcga gtccggtcgc aggtcgacga tgacgtcgaa cacgcggccg
    12241 tacgaacagc ggaccagctt cgcctccccg cgcccggacc gcaggtgcat cccgcgcagg
    12301 acaccgcgtg ccgagcgcga cacgctgtcc tgcgcgaaac cgtccgggtc gatgccggcg
    12361 gaccgcacga cctccgcgtc gaacgtgcgg cagaagaagc cgcgctcgtc ggcgtgcggc
    12421 gacggctcga acacgtacgc accggcgatc tcgggcacgg ggatggcttt cacgtcattc
    12481 tcccttggac gcaaggaaat aggcgtagcg gcggtccagc tcgttctccg ggacgagaac
    12541 gacgttctcc ggccgcaggc cgcacttggc gaccaactgc cagaactcgg ggacggagta
    12601 ggtggtcatg cccgccacgc tggtgcggta gccgcggcgg cgtgggcgcg tccagaagtc
    12661 accttcgtgg tacttcacct ggatcagcgc cagtccgccc ggcgcgagca cgcgggacgc
    12721 gatccgcagc aggcgttcgc cgtactcggg ggtggggatc agttcgaaca ggtagaagca
    12781 gaggaacagg tcgcaggtgc cgatctcctc gacgacccgc tcgggacgcg tgacctccgc
    12841 gagcaccggt gtgaacgggg tgtcgcagtg cgcggtcacc tgccgtgcgc actcctccag
    12901 tgtttccggc accacgtcga cgccgacgaa ctcggccgcc ctcggtgcga agtggacagc
    12961 gttggcgccg ccgccgcagc cccactccac cacgcgcccc agcgggcgat cgaacccgac
    13021 cccgcgtgcc ccgcggtcga acatctccag gtgccgcttg ccgatctcgt gccacaggtc
    13081 gccgtcgtcg aagacgtgtg cgccccgcca gtgcgagttc gccttccacg acgcgcttcc
    13141 cgtcgacgcc cagtagtcct gggcgtccgc ggcgatccgg gactcggact gggacagccc
    13201 gacccgcgtg aggacccgct gtacgaggtc ctcggcccgg ctgcccgcct gccgcacaca
    13261 tgccacaaca ctcgggggac gaaccgaccc gtgccgccgt cgtccagccc tgaagttcaa
    13321 gaacccacct cctgtgtcac ctccgccggc attcccagtg atgccgacaa cacttcgaac
    13381 tgccgcgcga gacgcgcgga cttgcgtgcc gcatgctcgc caagcatggg cccgatccgg
    13441 tccgcggccg cctcgaccgc ggtgaactgt tcgaccagcc ggtccacgtc gacggtcctg
    13501 gcgtcctgcg tgtactccgc aaggcccatg tccgccatga tccggtcgtt cttcgccgag
    13561 tagctgaccg agatggtcgg cttcgcgagc ttcaacccgc acaacacgtt gtggtagcgg
    13621 gtgccgacca ccacctcgga cttcgcgatc tgtgccatca cgtcgccgag ggtcctgatg
    13681 gtctcgtacg tcaccgcgcc ggggcggtcc ttcgagtcgg ccagcacctg ctcgacgatc
    13741 gcctcgtcca cctcgtcgcc gatgagcagc cgcacgcggt ggccgccgtc gaccagccag
    13801 cggacgaacc gccgcattcc gtccacatag gtccggtgga tggcctcggc gctggcgcga
    13861 tcgtcgttgc tgccgtggaa gtccatcaga cccaccgcga ccgtgccgcg ctccacggtg
    13921 acctccgggg caggcagggc gaacacgagg tccgggaaga tctcgtcgcg ggcggtgtcc
    13981 acccccatgg tggcgagcgc gtcgcgggac aggctgtcgc ggaaggatcg gtagtgcgcg
    14041 aggcgggtgg cccagcggat gaagaaccgc atcgcccgct gcctgatcac gttggagccg
    14101 acgttgacga acgcgacctt cgtgccggtg agcctgccga agaagctgag caggaacagc
    14161 gacagcggaa aaccccacgc ccgcaacgga agcgtgttct ccagcacgcc ggcgcccggc
    14221 acgatcacca cgtcgttgcg ccgcacccag cgccacacct gtgccgcgtc gcggaacttg
    14281 gcgaccgact tcagcacgac ccgcgcgggc aggccggagt cgcggtcccg ggtgtagtac
    14341 gagtagagcg ggacggccgg gacgccgtag cgcgcctcga cgacgtccgg accggaggcc
    14401 agggcgctca gctcggccga cgggtggtgc tcgcgcaggt aggcgagcac gacctccagt
    14461 gagccgtcgt tgcccatgtt cccggcgccg agcaacccga acagaccgac cttcaccggt
    14521 gcgctcccct cggcacgatg ccgtcgatcg acaggacctg gttcttcggc gcgaccgcgg
    14581 gcctgctgtc ggcgctcacg accttgcgcg tcaccctgct gctcaggtac tcggccaggt
    14641 gccggtagca cgtccgcttc tcggcggcgc tgatcggcgc gcggcggatc aggccgacgt
    14701 acccgagcgc gtactcggcg agcagccggg gggccgggtt gaaacccgtg gcgcgcttgg
    14761 ggtcgaggtt cgcgcagcgg ctgcggatgc tcgggttggc gcgctccgcg cggttctcgt
    14821 ggtcgcggcg gaagtacagc agctccgcca cctggtggaa acggccctgc atggccatgt
    14881 ccatcacgaa cgtgcggtcg gcgtggtggt agctgtcgtg cggcttgacg cggcgcaggt
    14941 ccgccgtgcg gatgacgccg tagaagtcgt cgccgccggg tgcgtgcagc aggccgcgga
    15001 accgttccgc cgcggacggc gagtcggtgg ggatgcggta gtcgtacggc tcgatgatct
    15061 tgccgtggct gtcgatcgtc gcgttgtagg agtgcgcgag gacgaagtcc gggttgtcgt
    15121 cgaggaactc gacgcagcgt tcgagcagcg tgcggccgta gaggtcgtcg tgcgatgccc
    15181 acttgaacag ctcgccgctg gcgagggtga acacgtggtt gtggttgccc gcggcaccga
    15241 tgttcctcgg caggcggtgg tagctgatgc gggagtcggc cttcaggtac cgcttgcaga
    15301 tgcccgcggt gccgtcggtg gacgcgttgt cggtgatgat cagctcgtag tcctcgaagg
    15361 actggccgag caacgcgtcg agcgactccg cgaggtactc ctcgccgttg tagaccggca
    15421 ggccgatggt gagtctcggg gtcatgaggt cctcgattcg gcaaggttcg ggagttcggg
    15481 ttcgggagtg tgctcgcgca gcgccgcgcg cagttgcagc caccacaggc ccgcgccgag
    15541 ccacatggcg gtggtggagc cccagctcat gccgaccgcg ccacccagcc acgcgcctgc
    15601 caggccgaag ccgaggtagc ccgaggacgc gaccagctgt gcccgcaggc ttctgcgtgc
    15661 cgcaccgagt gcgcggagcc cggccgccgc gcccgcgacg acaccggcgc cggtgaccga
    15721 cagggacacc ggcaggatca gcggctgtgc gtgcgtccag acgtcgtcga gcacgagcct
    15781 gccgagcgcg tccggcacga ggaacagcag gatcacgccc caggtcgcgg ccgcgacggc
    15841 ctgcacgcca ccgagggtga ggcagaaacg ggcgagtctt cctggggctc tgcgcaggac
    15901 gcgagccgct tccggcaccg cgaccaggtt caaccccatg agcagcgcga ggaacgggcc
    15961 gagcagcagc tccgcgccgc ggatcgcgcc gacgtccgcg agaccggcga tcgcgccgag
    16021 accgtacatc cgcagctggg acgcgccgga gttgctgacg ttctcgacga ggtagcggga
    16081 gccgaggtcg cggtgcgcgt gcagccagtc acggatgccg ctgaagtgcg gcgtgatccc
    16141 gctctgcagc cagccgcacc cggcggcgag cagcgacgcg ccaccccagg cgagcacgaa
    16201 accccacacg gtgccgtgca gggaagccag cagcagcaac gggatcatgg tgacggccca
    16261 cacgacgtcg ttgacgaacg ccttgtgccc cgcaccggcc gcgaagaacg cgaaccgcca
    16321 gctgtcctgc agcagcatgc cgggtgcgac gaccgccagc gcgacgaacg cgtcccccag
    16381 cgtgccgccc atggcgaacc cggcgagcgc ggagaccacg ccgaacgcgg cgcccacggc
    16441 gatcgcggta ccggcggccc gtgacgtcgc gtgccgccag tccgctgtgg acaccccgct
    16501 gaaccgcacg accagcgggt cggtggcgag accgcgggag acgttgagga cgacgccgta
    16561 ggtgacccag gcgaggctga agatgccgaa cgcggcgacg ccgagttcgc gggcgacgaa
    16621 cacgccgacc acgaagttcg tcatgctcga cacggcctgg tcgccga
//
