LOCUS       NZ_JACHJK010000013     29623 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Streptomyces echinatus strain CECT 3313 Ga0436950_13, whole genome
            shotgun sequence.
ACCESSION   NZ_JACHJK010000013
VERSION     NZ_JACHJK010000013.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces echinatus
  ORGANISM  Streptomyces echinatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 302204)
  AUTHORS   Whitman,W.
  TITLE     Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the
            genomes of soil and plant-associated and newly described type
            strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 302204)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 160.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014203595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 05:39:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,466
            CDSs (total)                      :: 8,381
            Genes (coding)                    :: 8,094
            CDSs (with protein)               :: 8,094
            Genes (RNA)                       :: 85
            rRNAs                             :: 7, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 5, 1 (5S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 287
            CDSs (without protein)            :: 287
            Pseudo Genes (ambiguous residues) :: 0 of 287
            Pseudo Genes (frameshifted)       :: 116 of 287
            Pseudo Genes (incomplete)         :: 236 of 287
            Pseudo Genes (internal stop)      :: 12 of 287
            Pseudo Genes (multiple problems)  :: 77 of 287
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 18630
            Orig. end                         :: 48253
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACHJK010000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..29623
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /product="betalactone"
                     /region_number="1"
                     /rules="AfsA"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..29623
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="neighbouring"
                     /product="butyrolactone"
                     /product="betalactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10966
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10966
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5966](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5966
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            complement(479..1447)
                     /locus_tag="FHS34_RS30440"
                     /old_locus_tag="FHS34_006168"
     CDS             complement(479..1447)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058858.1"
                     /locus_tag="FHS34_RS30440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006168"
                     /product="adenosine kinase"
                     /protein_id="WP_184971343.1"
                     /transl_table=11
                     /translation="MTSDTDVLVLGGAGVDTVVHVPELPLAFADSYMIRPGITARAGQS
                     GDFVALGLTALGLRTHHLDMIGDDTEGDLVRALHRDHGIPLTAIPQPAGTKRAVNLVGP
                     DGRRLSLYDDTRSTASDRLPEATVRELAAASRHAHVVITPPCAQALPLLREAGLTLSTD
                     LHDWDGADPYHEPFALEADLVFLSATALADPERTLRDIAARGRARIVVATAGAQGAHLL
                     ADGELIHVPPAEPPAPVVDSNGAGDAFASGFLFGWLNGEDPRRCARYGAIAGAHACTVP
                     STRTDVITRTELLARAARPESPAATPAAVEEGDRALIPGLD"
     misc_feature    complement(1509..1523)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.56"
                     /tool="antismash"
     misc_feature    1513..1529
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.86"
                     /tool="antismash"
     gene            complement(1614..1961)
                     /locus_tag="FHS34_RS30445"
                     /old_locus_tag="FHS34_006169"
     CDS             complement(1614..1961)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHS34_RS30445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHS34_006169"
                     /product="hypothetical protein"
                     /protein_id="WP_184971345.1"
                     /transl_table=11
                     /translation="MRACRDLFTDFFRTAGATPGYARQLLRSRELYRHLKSAGLTGVRQ
                     RTVLIEHHAPLPDAAREFCAMACAQLARQALDLGLSAEGQRFADPAGPRHPLDDADACI
                     SEGNVLAVGTV"
     cand_cluster    2070..29623
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    2070..29623
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[12069:19623](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(12070..19623)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="2"
     gene            complement(2104..2778)
                     /locus_tag="FHS34_RS30450"
                     /old_locus_tag="FHS34_006170"
     CDS             complement(2104..2778)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018850061.1"
                     /locus_tag="FHS34_RS30450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006170"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_184971347.1"
                     /transl_table=11
                     /translation="MAQQLRAIRTRGAILHAAAEVFAQHGYHGASIAQILEKAQVTRGA
                     LYFHFASKEQLVQGIFAQQVTEQGYPVRTYKLQELVDEAMALACRLPQEIMLRAGAKLA
                     MEPQLQELADGGPWEAWAQRFASMVDAAKRHGEVYPHVAPGDLGRFLVSSWIGAQVVSE
                     VTSDWTDLEGRISSLFAYTLPSVALPAIFAQLEFGPDRGTRVLAEMRADQEEPRLVAER
                     TR"
     misc_feature    complement(2763..2776)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     misc_feature    2804..2817
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     misc_feature    2885..2899
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.29"
                     /tool="antismash"
     misc_feature    2886..2899
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.76"
                     /tool="antismash"
     gene            complement(2932..3705)
                     /locus_tag="FHS34_RS30455"
                     /old_locus_tag="FHS34_006171"
     CDS             complement(2932..3705)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (11-177). E-value: 1.2e-12.
                     Score: 40.1. Matches aSDomain:
                     nrpspksdomains_FHS34_RS30455_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960779.1"
                     /locus_tag="FHS34_RS30455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006171"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_184971348.1"
                     /sec_met_domain="adh_short (E-value: 2.5e-36, bitscore:
                     119.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYGAGMLAGRVMLVTGASSGIGAATARVAARHGAALVLMARRAP
                     RLEELAAELRDKGAEVACSGGDVTRSDDVERAVRLAVDRYGRLDAAFNNAGTTTEPALL
                     HETDDADYDTVLDVNLRGVWLCMKHEIRAMLAAGTGGAIVNNSSIAGVRATSAGAPYVA
                     AKHAVLGLTKAAAAQYAEHGVRVNALATGLTRSEMSESLFARDPAAEERMRRRNPQGRV
                     ADPEEVGQVAVWLCSDQASFVTGATMAVDGGAGAW"
     aSDomain        complement(3175..3672)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHS34_RS30455_PKS_KR.1"
                     /evalue="1.20E-12"
                     /label="FHS34_RS30455_PKS_KR.1"
                     /locus_tag="FHS34_RS30455"
                     /protein_end="177"
                     /protein_start="11"
                     /score="40.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VMLVTGASSGIGAATARVAARHGAALVLMARRAPRLEELAAELRD
                     KGAEVACSGGDVTRSDDVERAVRLAVDRYGRLDAAFNNAGTTTEPALLHETDDADYDTV
                     LDVNLRGVWLCMKHEIRAMLAAGTGGAIVNNSSIAGVRATSAGAPYVAAKHAVLGLTKA
                     AAA"
     CDS_motif       complement(3577..3666)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHS34_RS30455_0001"
                     /evalue="6.40E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="FHS34_RS30455"
                     /protein_end="43"
                     /protein_start="13"
                     /score="15.6"
                     /tool="antismash"
                     /translation="LVTGASSGIGAATARVAARHGAALVLMARR"
     gene            complement(3702..4421)
                     /locus_tag="FHS34_RS30460"
                     /old_locus_tag="FHS34_006172"
     CDS             complement(3702..4421)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953814.1"
                     /locus_tag="FHS34_RS30460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006172"
                     /product="HAD family phosphatase"
                     /protein_id="WP_184971349.1"
                     /transl_table=11
                     /translation="MTEQLGRIRMAALNIDGVLLNDTFSPVIHHFVTSRGGTYSADLER
                     RIFSQPQVVAGRVLAETCGLSTTPMETIALYLRERESYLADHPVRILDGAVDLLRRLRA
                     LGLRTVCYGGLDASHFQRFLGHLDGLFDEPRYVCTNDIRPGLREIAVDVAGLACDEVLF
                     IDDVARVAEAARELGVPFVGHPSDFAHGHQRQLMTEAGVRHLVGSLDEIDDRLLRTIDA
                     ETEAGTLWDRAAGKALA"
     misc_feature    4550..4565
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     misc_feature    complement(4694..4710)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.23"
                     /tool="antismash"
     misc_feature    4694..4710
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.2"
                     /tool="antismash"
     misc_feature    4861..4879
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.38"
                     /tool="antismash"
     gene            5001..5966
                     /locus_tag="FHS34_RS30465"
                     /old_locus_tag="FHS34_006173"
     CDS             5001..5966
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018850064.1"
                     /locus_tag="FHS34_RS30465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006173"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_225817690.1"
                     /sec_met_domain="AfsA (E-value: 5.7e-22, bitscore: 71.7,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTFAPIDSMVRDFRAALPATTPVGLTTLTTTVPKEYVHRAAVTE
                     VFLTGWRQTDANTCTVTAQWPRAHSFYGPAAGFHDPLLFSETLRQTVPLLSHAVYGAPM
                     DHKQIWRDLRVSLEPGALRAGTVPAELELRIRCSDIEQRGGVLRGLRMEVTATCDGLPL
                     ATASTTFSSHSGALYRRLRGAYADAGQAMADAVEMPPPLRPELVGRDRPHDVVLSPRGD
                     DGRWQLRVHTLHPIIFDHPNDHAPGMLLLEAARQAAQHHLGPAPVLATGIDAAFHRYAE
                     LDAPSWVTAESLGDGRVRVTVEQDGELAFECAVTTHPAVA"
     gene            complement(6114..6872)
                     /locus_tag="FHS34_RS30470"
                     /old_locus_tag="FHS34_006174"
     CDS             complement(6114..6872)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (14-164). E-value: 7.8e-12.
                     Score: 37.4. Matches aSDomain:
                     nrpspksdomains_FHS34_RS30470_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005818.1"
                     /locus_tag="FHS34_RS30470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006174"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_184971371.1"
                     /transl_table=11
                     /translation="MATLSRTQPSDSLVAVVSGGASGIGAAAAAALIARGVRVAALDLD
                     SGQVAAPAVGIACDVSDDASVRAAVDEVVARFGRIDIVVNNAGIAAQGDVSANDDDEWR
                     RVLDVNVIGMVRLARAALPHLRKSPAAAIVNTCSSFALTGVPRRVLYSTSKGAVHAMTL
                     AMAADHVREGIRVNAVAPGAVDTPWIQRMLARTPDPEAARDALNDRHPLGRTARPEEVG
                     EAIAYLATPASSATTGTVLSVDGGIHTLRL"
     aSDomain        complement(6381..6830)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHS34_RS30470_PKS_KR.1"
                     /evalue="7.80E-12"
                     /label="FHS34_RS30470_PKS_KR.1"
                     /locus_tag="FHS34_RS30470"
                     /protein_end="164"
                     /protein_start="14"
                     /score="37.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="AVVSGGASGIGAAAAAALIARGVRVAALDLDSGQVAAPAVGIACD
                     VSDDASVRAAVDEVVARFGRIDIVVNNAGIAAQGDVSANDDDEWRRVLDVNVIGMVRLA
                     RAALPHLRKSPAAAIVNTCSSFALTGVPRRVLYSTSKGAVHAMTLA"
     CDS_motif       complement(6759..6827)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHS34_RS30470_0001"
                     /evalue="2.00E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="FHS34_RS30470"
                     /protein_end="38"
                     /protein_start="15"
                     /score="10.9"
                     /tool="antismash"
                     /translation="VVSGGASGIGAAAAAALIARGVR"
     gene            complement(6988..7746)
                     /locus_tag="FHS34_RS30475"
                     /old_locus_tag="FHS34_006175"
     CDS             complement(6988..7746)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237777.1"
                     /locus_tag="FHS34_RS30475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006175"
                     /product="arylmalonate decarboxylase"
                     /protein_id="WP_184971373.1"
                     /transl_table=11
                     /translation="MDIFPLPRLGLVVPPENPIAEPEFHRLIGSEMNVYTSRFPLTPGM
                     GVKETMESYNEVLPETLAAFGRMRLDAAVVACNASHYLLNPQGDRAFVAELSERLGFPV
                     QSSTQAILAVCEEFGTTRLTLVSPYWPWLTETSRSFWEQAGLKVDTVVLAPAVPGRAAE
                     EHEFDPYRVTTRTLLTQVREAGLPDEGVVLFTGTGMGTLTALAELDREFGRSTLLTSNL
                     ASAWWARRTVGAAGAEVHPLLERLERGAGR"
     misc_feature    7839..7853
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.24"
                     /tool="antismash"
     gene            7953..8138
                     /locus_tag="FHS34_RS30480"
                     /old_locus_tag="FHS34_006176"
     CDS             7953..8138
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967615.1"
                     /locus_tag="FHS34_RS30480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006176"
                     /product="lysine biosynthesis protein LysW"
                     /protein_id="WP_184971375.1"
                     /transl_table=11
                     /translation="MSSATLTGACPECETELTVPPVVQGETLSCPECMLTLRVEGVEDG
                     ALTLEMVEVQLRDWGQ"
     gene            8144..9430
                     /locus_tag="FHS34_RS30485"
                     /old_locus_tag="FHS34_006177"
     CDS             8144..9430
                     /NRPS_PKS="Domain: Aminotran_1_2 (48-379). E-value:
                     3.3e-38. Score: 123.6. Matches aSDomain:
                     nrpspksdomains_FHS34_RS30485_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609642.1"
                     /locus_tag="FHS34_RS30485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006177"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_225817689.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.5e-37, bitscore:
                     123.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGAPPVPMSATLAADEVLARRRRAGEQVLPMAGGEIGLPVLPAL
                     RRRLAAAAGLNAYGPVPGSHALRASAAGYWGRRGLGTDPGLVVAGPGSKPLLFALLLAI
                     GGDVVVPVPGWVSYAAQARLAGAHPVPVATAPGQGGVPDPERLRTAVAAARAAGRDPRC
                     VVVTLPDNPTGTVASPGTVRRLADAARELDLVIVSDEIYCDLVWDTSVPAESPARHAPE
                     RTVVTTGLTKNLAVGGWRTGVARLPDSDTGRSLHGRLVPVASQIWSSPPAPVQAAAAYA
                     FGEPPEIAAHVAACRALHERVVRAVAGRFTGAGADLAPVRATCYLYPDFGPLRDRLAHT
                     HDVHGGEGLVRFLGERHGIGVLPAGAFGEPGDPLRIRAATSRLYGEDDEQRTTALAAPD
                     PLELPWIRRNLEQIGAALADLTGSPVTGS"
     aSDomain        8288..9280
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHS34_RS30485_Aminotran_1_2.1"
                     /evalue="3.30E-38"
                     /label="FHS34_RS30485_Aminotran_1_2.1"
                     /locus_tag="FHS34_RS30485"
                     /protein_end="379"
                     /protein_start="48"
                     /score="123.6"
                     /tool="antismash"
                     /translation="LAAAAGLNAYGPVPGSHALRASAAGYWGRRGLGTDPGLVVAGPGS
                     KPLLFALLLAIGGDVVVPVPGWVSYAAQARLAGAHPVPVATAPGQGGVPDPERLRTAVA
                     AARAAGRDPRCVVVTLPDNPTGTVASPGTVRRLADAARELDLVIVSDEIYCDLVWDTSV
                     PAESPARHAPERTVVTTGLTKNLAVGGWRTGVARLPDSDTGRSLHGRLVPVASQIWSSP
                     PAPVQAAAAYAFGEPPEIAAHVAACRALHERVVRAVAGRFTGAGADLAPVRATCYLYPD
                     FGPLRDRLAHTHDVHGGEGLVRFLGERHGIGVLPAGAFGEPGDPLRIRAA"
     gene            9481..10722
                     /locus_tag="FHS34_RS30490"
                     /old_locus_tag="FHS34_006178"
     CDS             9481..10722
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004943454.1"
                     /locus_tag="FHS34_RS30490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006178"
                     /product="MFS transporter"
                     /protein_id="WP_184971377.1"
                     /transl_table=11
                     /translation="MTSAEPSTGTAAPSLPPSDATSAADPKLPLAALLALAVAVFITSL
                     TETLPAGLLPDMSASLHTGESATGQTVTVYALGTVLTAIPLSAATAGWDRKRLLLTTMA
                     GFAVANTVTALSVNYPLTLVARFVAGVAAGLAWALLAGYARRMVAPHQEGRAMAIAMAG
                     IPVALSLGVPAGAFLGRVVSWQAAFLAMTALTVVLLGWITVVAPDHPGRRTAGTIPVRG
                     TLRVPGVTPVLVVTLVFVLAHTILYAYIAAFLDHAGMGGQVDAALLVFGVACLVSIWAV
                     GTCIHAHLRTLTVAATLLVAVAVAVMGVFSGTDALVYVAVALWGLGWGGVPTLLQTAAG
                     QAGGESADAAQAILVTLWNVAMAAGGVAGGLLLDGVGADAFPWTVLILLVPVLAVVLAA
                     RAHGFPARRPAGPS"
     misc_feature    10793..10807
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.9"
                     /tool="antismash"
     gene            10801..11730
                     /locus_tag="FHS34_RS30495"
                     /old_locus_tag="FHS34_006179"
     CDS             10801..11730
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379932.1"
                     /locus_tag="FHS34_RS30495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006179"
                     /product="fumarylacetoacetate (FAA) hydrolase"
                     /protein_id="WP_184971379.1"
                     /transl_table=11
                     /translation="MSIIFECEYQGRRYAGHGIPATGSTLTLFPVADGQLRAALVAGRG
                     PEDLGAALPGDGERIEVALGDPGLRFLPPLLPTASNNSLVNGFMGTHRSKFDRAPEPDE
                     EFTPPNYYIKGFGSWLRLPDEPLTTQSDPVWLLEEPEVVLVYANDEQGVPHYAGYTFGN
                     DLNDIGLHLKNPWAWTPYAKLCETSIAPWLFLGTPPETVTGTVTIERDGGQAWRGDFSC
                     GADSLFHRIPDMADYLFRHPLLRRPGLVNYLFLGADKATYHDGFRIENGDRMVLDVSSH
                     GVVLANEVRYGAAAPEQHGFPRPESEPA"
     gene            complement(12070..13731)
                     /locus_tag="FHS34_RS30500"
                     /old_locus_tag="FHS34_006180"
     CDS             complement(12070..13731)
                     /NRPS_PKS="Domain: AMP-binding (38-454). E-value: 1.5e-79.
                     Score: 259.4. Matches aSDomain:
                     nrpspksdomains_FHS34_RS30500_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947777.1"
                     /locus_tag="FHS34_RS30500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006180"
                     /product="AMP-binding protein"
                     /protein_id="WP_184971381.1"
                     /sec_met_domain="AMP-binding (E-value: 2.7e-85, bitscore:
                     280.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTGYAPAAAPAAVPAPDRAAEYRSCGWWRDETFLDDLRRQARIR
                     PRKLAVAGRRLDEARTDTLDYAELSLLTDRFAGALLELGVRRGDVVAVQLPNRWEMVPL
                     MYACMAVGAVICPIAPECQEAELSHRLQLTGARVCVTLAEWQDHPLAASITALRPQLAV
                     EHVVVVGGRGPEGTVDFHDHFVAVPWEEEHLDDLEGRELGPDEPFVILFTSGTTGFSKG
                     VVHSQNTVHSGVRGYVDTFLLRDDLVAVVTTPLVHYSGFGQGILAGVMLGGTVAFQDGR
                     NHTSLLDLAERYGATLLYGPPATLFGVAAAQRADRHEVPSLRHTVTGAAPVLQELVDEL
                     RDTFDTTTYSVWGMSEFGPITISRLDYDQDWSAHSHGRPIDAMQIRIDLCDNPDKRAEV
                     GRLRVRGASRALGYFRNQDAFDAELTADGWFDTGDVARADGRGGIRVLGRAKDAILRDG
                     AVVPMAELEAILAAHPKIAEATLVGPHGRTDDPVVAVVVPRGGARPTLREIREHLRERG
                     QDPRFLPDRLDLVDTLPKTLTGKVRKAELRRRLGGD"
     aSDomain        complement(12370..13617)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHS34_RS30500_AMP-binding.1"
                     /evalue="1.50E-79"
                     /label="FHS34_RS30500_AMP-binding.1"
                     /locus_tag="FHS34_RS30500"
                     /protein_end="454"
                     /protein_start="38"
                     /score="259.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RRQARIRPRKLAVAGRRLDEARTDTLDYAELSLLTDRFAGALLEL
                     GVRRGDVVAVQLPNRWEMVPLMYACMAVGAVICPIAPECQEAELSHRLQLTGARVCVTL
                     AEWQDHPLAASITALRPQLAVEHVVVVGGRGPEGTVDFHDHFVAVPWEEEHLDDLEGRE
                     LGPDEPFVILFTSGTTGFSKGVVHSQNTVHSGVRGYVDTFLLRDDLVAVVTTPLVHYSG
                     FGQGILAGVMLGGTVAFQDGRNHTSLLDLAERYGATLLYGPPATLFGVAAAQRADRHEV
                     PSLRHTVTGAAPVLQELVDELRDTFDTTTYSVWGMSEFGPITISRLDYDQDWSAHSHGR
                     PIDAMQIRIDLCDNPDKRAEVGRLRVRGASRALGYFRNQDAFDAELTADGWFDTGDVAR
                     ADGRGGIRVLGRAKDAI"
     CDS_motif       complement(13054..13104)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHS34_RS30500_0001"
                     /evalue="2.00E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="FHS34_RS30500"
                     /protein_end="226"
                     /protein_start="209"
                     /score="17.3"
                     /tool="antismash"
                     /translation="ILFTSGTTGFSKGVVHS"
     gene            complement(13728..14846)
                     /locus_tag="FHS34_RS30505"
                     /old_locus_tag="FHS34_006181"
     CDS             complement(13728..14846)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609640.1"
                     /locus_tag="FHS34_RS30505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006181"
                     /product="Glu/Leu/Phe/Val dehydrogenase"
                     /protein_id="WP_184971382.1"
                     /transl_table=11
                     /translation="MSDAENTQDPALVVHLNGSGGTIRSWVVIDTLVDGLAMGGVRMTP
                     GVTVEEVAGLARDMTQKFTLAGLRIGGAKGGIVSDGGDREQTFRTFGRTVKPLLHGGIH
                     LGIDMGVTPADRAVFFDEAGYDPRYRPGAPDMPVDWRTYYEPLIDVTGHGVGVAAVTAL
                     EASGRGEAARVVVQGFGAVGRAVARFLEDRGHVVVGVADVQGTISADRLPVAELIAVTD
                     EFGRIDRSRLPQHVTTTSTPDAWLDIDADVLVLAAQKHALNAENAHRLRAGLVVEGANL
                     ASDAEAREKARAAGATLVPGVIANIGGAGAAALAVTRVVPFELAADARKAWVFDWIGDR
                     VRENTRALLEIAAARAGDPLPELLDVRRGELR"
     gene            complement(14896..15459)
                     /locus_tag="FHS34_RS30510"
                     /old_locus_tag="FHS34_006182"
     CDS             complement(14896..15459)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609639.1"
                     /locus_tag="FHS34_RS30510"
                     /note="Members of this family of hydrolases with an active
                     site Cys residue belong to MEROPS family C26.; Members of
                     this family of hydrolases with an active site Cys residue
                     belong to MEROPS family C26.; Members of this family of
                     hydrolases with an active site Cys residue belong to MEROPS
                     family C26.; Members of this family of hydrolases with an
                     active site Cys residue belong to MEROPS family C26;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006182"
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="WP_184971385.1"
                     /transl_table=11
                     /translation="MAKTRVLVVNNKTLSLPQLRGRFETLGSDTDTVDAASVPSRLDGR
                     YQAIVLSGTKVRAYDQDYYKPLVDLVMTSDVPVFGICGGMQILAVAAGGRLAEGPQRVG
                     GYEVQVDKDEPLFTHVKPTVTVFHRHTLYLREAPEGFRSIGRSEHAPVEFLRSDDGRIH
                     GSQAHLEFRGDGLEILRGFAQLYQ"
     gene            complement(15471..16268)
                     /locus_tag="FHS34_RS30515"
                     /old_locus_tag="FHS34_006183"
     CDS             complement(15471..16268)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1174: acetylglutamate kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489666.1"
                     /locus_tag="FHS34_RS30515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006183"
                     /product="acetylglutamate kinase"
                     /protein_id="WP_184971387.1"
                     /transl_table=11
                     /translation="MTGIQHAPTVVKLGGSCLADLDGSWWDDLARHGRERPLVLVHGWS
                     KPLKALSPRYSEPSAILRDRYGNQSRWTTPEVIADIKTVSADLGAEVLRRLERRDITAE
                     RLLGSDGLVAAGEGERWWWKDKRLVELENLVGPITGVDPAPLAKLRPGHAHLVTPLARD
                     SAGREVNTDADRAAAAIAGATGATDLILVTDVAHLLIDGQPVREITAEAAAEFRDKGAT
                     GGMRKKLRAAGEALDRGVERVVIGSAPVSDLLAARTGTVITRT"
     gene            complement(16265..17323)
                     /gene="argC"
                     /locus_tag="FHS34_RS30520"
                     /old_locus_tag="FHS34_006184"
     CDS             complement(16265..17323)
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070401 - NADP+ binding [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379927.1"
                     /locus_tag="FHS34_RS30520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006184"
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_184971389.1"
                     /transl_table=11
                     /translation="MIRVGIVGASGLAGGELIRLVSQHPELELTFLGGDSSAGRRPAEL
                     HPGLRLDLGLTVEPVTADRVAEKCDVVFLATPAPVSARLAAELADRVPCVTDLSGAFRI
                     RTPELHRRWYAKAERATELADRFVYGVPELVGDQLVDAALISVPGCYATAITLGLAPLT
                     LGLGLHLRTVVVDGKSGSSGGGLQLRVPDLHPLRNGAIAPYAPTGHRHAAEVGDFLRRS
                     KPGSVGSLAMSAYGVSHVRGLLASSYVYTDDPVDQRTLQRAYFRFYKEHPFVRVRRHDE
                     TLIPVPDPQAVLGSNYCDVTAMHDPDGGRIVVLAALDNLVKGAAGQAVQAVNKRFRLPE
                     ETGLTMQPVMPA"
     gene            complement(17320..18168)
                     /locus_tag="FHS34_RS30525"
                     /old_locus_tag="FHS34_006185"
     CDS             complement(17320..18168)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947772.1"
                     /locus_tag="FHS34_RS30525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006185"
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_184971391.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.7e-10, bitscore:
                     34.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 1.7e-27, bitscore: 90.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 2.5e-10, bitscore:
                     34.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGRVAVVADRVGWEERRLIETGPDLGVRFDWVNDESLCAGHRDA
                     ESLKGYDAVMVRSRSYTRGGLIATLAEADGFRVLNSAQAIHSCENKLVLRAVLREAGVP
                     VPDFRLALSRKDFERALGELGVPVVLKPVYGGMGKRVTLVRDSDLAQSVYDYVEDLGHA
                     FEQACLVEPYLGGGSIRCLVVGRDIVAAAEFESAGTDWRSNAALGSQSRALAHDPEVQK
                     IVDGVVDRLGSGIYGVDLFKTGSGYLVNEVNHAPAWRGVASTTGTDIASVVVRYVQETL
                     E"
     misc_feature    18163..18173
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(18170..18355)
                     /locus_tag="FHS34_RS30530"
                     /old_locus_tag="FHS34_006186"
     CDS             complement(18170..18355)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967615.1"
                     /locus_tag="FHS34_RS30530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006186"
                     /product="lysine biosynthesis protein LysW"
                     /protein_id="WP_184971393.1"
                     /transl_table=11
                     /translation="MSTAVLTGSCPECETDLTVPEMVVGETLSCPECMLTLRIEGIENG
                     RLGLQMVEVQLRDWGQ"
     gene            complement(18472..19623)
                     /locus_tag="FHS34_RS30535"
                     /old_locus_tag="FHS34_006187"
     CDS             complement(18472..19623)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947770.1"
                     /locus_tag="FHS34_RS30535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006187"
                     /product="LeuA family protein"
                     /protein_id="WP_184971395.1"
                     /sec_met_domain="HMGL-like (E-value: 1.4e-48, bitscore:
                     159.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADPENDGSLPGLPQLSDATLRDSAHMGGVEFGPKDAAVIADLLV
                     RTGIDLVEVGMVSGPDSKDADLVLATHEAIGPERSMTLLVVRDREQVAKALDEAERLGV
                     RHIMYSIPTSEQHAGLKLGSPSAKFLQVLARSAISQAKDRGFHVTFSGEDGARTPKERL
                     IPYVAAGFEAGADRFRLAETVAYLSPWQMEEVISGLTAIDGSEIEIHSHNMLGMAVANS
                     LAAVRAGARWISATVGGIGERGGNAPLAELLTSLRVIHGDTRFDLTHLTELSRAALRGA
                     GLGDAFQSGPTTPHAFAYELPGQLSNPEAYETLPAELVGNSRELRVRTRLTPALVKWAL
                     AGSDIAVDVEAFTAWLIERQELAGRPVLDQEAVRKAAIDFQAA"
     gene            complement(19907..20647)
                     /locus_tag="FHS34_RS30540"
                     /old_locus_tag="FHS34_006188"
     CDS             complement(19907..20647)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-124). E-value: 1.3e-14. Score:
                     46.5. Matches aSDomain:
                     nrpspksdomains_FHS34_RS30540_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018842558.1"
                     /locus_tag="FHS34_RS30540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006188"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_184971397.1"
                     /sec_met_domain="adh_short (E-value: 6e-33, bitscore:
                     108.3, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 3.8e-33, bitscore:
                     109.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLTGKVALVTGGSRGIGAAIAKRLADAGAAVALTYVQAEDQAR
                     EVAKRIEADGGRAAVVRADLTRPDDAAEAVEQTVRELGGIDILVNNAGFLSYGPLDEVT
                     VEHLDQVLAVDVRSVFLAAQAAARHMGDGGRIISVGSCFNGRVPAGNFVLQATAKTALI
                     GLTKGLARELGPRGITATVVDPGPIDTDMNPADGDSADWQRSLTALGRYGEAEDIAAAV
                     AYLAGPGGRYITGTALAVDGGYTA"
     aSDomain        complement(20276..20626)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHS34_RS30540_PKS_KR.1"
                     /evalue="1.30E-14"
                     /label="FHS34_RS30540_PKS_KR.1"
                     /locus_tag="FHS34_RS30540"
                     /protein_end="124"
                     /protein_start="7"
                     /score="46.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGGSRGIGAAIAKRLADAGAAVALTYVQAEDQAREVAKRIE
                     ADGGRAAVVRADLTRPDDAAEAVEQTVRELGGIDILVNNAGFLSYGPLDEVTVEHLDQV
                     LAVDVRSVFLAAQ"
     CDS_motif       complement(20552..20620)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHS34_RS30540_0001"
                     /evalue="6.50E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="FHS34_RS30540"
                     /protein_end="32"
                     /protein_start="9"
                     /score="22.0"
                     /tool="antismash"
                     /translation="LVTGGSRGIGAAIAKRLADAGAA"
     gene            20749..21156
                     /locus_tag="FHS34_RS30545"
                     /old_locus_tag="FHS34_006189"
     CDS             20749..21156
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091427.1"
                     /locus_tag="FHS34_RS30545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006189"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_184971399.1"
                     /transl_table=11
                     /translation="MRIGELARRSGVSERSLRYYEAQGLLSAERTPGGHRDYGEWAVDR
                     VIRIQALYAAGLNSKKIAQLLPCMRDGDGSPSDSATPRLVDELTAERERLDRLIADLVR
                     SRDVLDDIIDTASTGLEAAPLTGSGGRPPGH"
     gene            complement(21182..24634)
                     /locus_tag="FHS34_RS30550"
                     /old_locus_tag="FHS34_006190"
     CDS             complement(21182..24634)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609628.1"
                     /locus_tag="FHS34_RS30550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006190"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_184971401.1"
                     /transl_table=11
                     /translation="MRFGVLGPLAVWDDEGEPVRVPETKVRALLADLLAQDGGPVSADR
                     LIHDLWGDSLPGNPAGALQAKVSQLRRVVGRERLLRQPPGYRLRLGSADEVDAARFGGL
                     LAEARSTADPRARAALLTEALKLWRGPAYADFADEEFVRAAGECLAEERLAALEERAEA
                     RLAAGEHRLLAGELAALVSGHPLRERLRAVQMRALYRAGHQGEALASYDDLRTRLAREL
                     GVGPGPALSALHRAMLRQDPALDADTQPPAASSDGVPPHPAPSPHPMTAPAPPASPAPP
                     ASSAPPTASAPLASPTPSTASPPPTSPAPPTPSASLSAPPAPSAPAGLPVPLTALIGRD
                     QALGRLSRLLGRERLVTLTGPGGVGKTRLAVAAARDVASGGAAGLADGAWFVEFAGVRT
                     ATATADALAGIVAATLGLRDDAPSAPPAVSPVATSPVHRLTAALRDRDTLLVLDNCEHV
                     VEAAAELVGRLLRGAPRLRVLTTSQEPLALAGESVFLVEPLHTPDAVRLFTERAAACAP
                     GFRLGSDDPDGAAADPGSDRAAVAEICRRLDGIPLALELAASRVRALGVRELAARLGDR
                     FRVLTSGQRGAPARQQTLRAVIDWSWELLDAPERAVLGRLAVHSDGCGLDAAEAVCAGD
                     GVPAGAVLDLVTRLVDKSLVVVTDGPTGPRYRLLESVAAYAVERLRETAGEPAARERHL
                     RHHLTLAERAERRLRGPLQRDWLTRLDTEAGNLRAALDEAVRRAAAGRGEEAVRLATAL
                     SWWWLLRGRLTEGRRALAAVLAATAPDPDPELTLLHGAFVLLTGERTVPAGADAVPDPV
                     RRARALWLNAHGMFGVGDLDGARAWNTRALAHFEAADDRWGIAAALGVRAALALVRGDL
                     DGLARDGRRSRALFRELGDRWGELQTVSPLAALAEIKGEYAQAAHRQHEGLQMARELCL
                     RAEVSARLSGLGRLALLARDFDRARDLHEQARRLAVEQGYKYGEIHADMGLALGARRSG
                     DIDAAEAHLLRIRADHADVSSAAGDHLLHAELGFIAELRGDAAESAAHQLRGLRIARSL
                     GEPRALALSLEGLAGTATLCGHRSGAVCAALLLGAAHAARRSVGAPLPPAERGDVDRVT
                     AAARAVLGVRAFEESFERGARLSPDEAERHARAALAALVDEAA"
     gene            24812..26077
                     /locus_tag="FHS34_RS30555"
                     /old_locus_tag="FHS34_006191"
     CDS             24812..26077
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675890.1"
                     /locus_tag="FHS34_RS30555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006191"
                     /product="MFS transporter"
                     /protein_id="WP_184971403.1"
                     /transl_table=11
                     /translation="MSLSPDTAAASDTAAAPGTEPGTAPPPRQDSGERRRGLPLAALLA
                     LATAVFVTSLTETLPAGLLPGMSHDLRVSESATGQTVTVYAIGTALTAIPLTAATAGWR
                     RKRLLLTAVAGFAAANTVTALSSVYGLTMAARFVAGVAAGVAWALLAGYARRMTPVPLQ
                     GRAIAIAMAGIPVALSLGVPAGTFLGQALGWRVAFLAMTALTVVLLGWIVAAVPDHPGR
                     PSGERPLMLRALGVPGVRPVLFVTLLFVLAHTVLYAYIATFLDDLGMGDRTDLVLLVFG
                     VTSLAGIWVVGARIHRRLRALTVAATLLVAAAATLLAVTGDGGAPVYVAAALWGLGWGG
                     LPTLLQTAVGDAGGDHADAAQAMLVTLWNVAMAGGGVLGGVLLEVTGSGSFPWTVLLLL
                     LPVLAVVLAARRHGFPSRRPGA"
     misc_feature    complement(26281..26295)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    26281..26295
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.1"
                     /tool="antismash"
     misc_feature    26282..26293
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.96"
                     /tool="antismash"
     gene            26532..27725
                     /locus_tag="FHS34_RS30560"
                     /old_locus_tag="FHS34_006192"
     CDS             26532..27725
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967609.1"
                     /locus_tag="FHS34_RS30560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006192"
                     /product="transposase"
                     /protein_id="WP_184971405.1"
                     /transl_table=11
                     /translation="MFVEKVFNSLHRAEQRRWAREYLWGLLHTPGKKTPRRMAEAGLLP
                     AGAAHGLHQFINGSPWNWQPVRCALAGTVAAGGPAYAWTCADLLIPKQGEHSVGVHRRL
                     DQATGRTINCQRALGLFLSTGTRCFPVDWSLVLDGEWDWDDLRRRRARIPEEETGRPVG
                     AYVIGFAAGVAAHTRLPDAPWVLNLTRRCDDASGVMAGLARRGLDFVCEVESRQIVLIG
                     RPAPRVITVGELMEEPHARQPHVLMRQTEHGGSRAVRVNVYGGPVRLSQRGAGKDGVSR
                     TYQVLELPSADGAQPPRYWITSLMSRGVEEVLTLARSQSTALATVATVREGFGVLDFEG
                     RSFPGWHHHMTMVSAAYAYQRLYGTPGAGSAPAVPLPVAHAGTTAHYADAGAKGLGA"
     gene            27722..28411
                     /locus_tag="FHS34_RS30565"
                     /old_locus_tag="FHS34_006193"
     CDS             27722..28411
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967610.1"
                     /locus_tag="FHS34_RS30565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_006193"
                     /product="response regulator transcription factor"
                     /protein_id="WP_184971407.1"
                     /transl_table=11
                     /translation="MKRVLVVEPDAGAAESTAGELRRQGYAAHTVDRGARMLRTYHDAD
                     LVLLSLDLPDIDGLEVCRTLRAESDIPVIACTHRDNELERVLALKAGADDCVLRTWSPR
                     EIGARIEAVLRRTRPQAAGADSISLRPLHIDPRTREVRLRDRLVDVTATEFELLYTLAA
                     RPDSVVSRKELMARVWGSNWVRTSRTIDTHVSSLRAKLGSSRWIITVRGVGYRMGHVGQ
                     MPEASAG"
     misc_feature    28604..28618
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.26"
                     /tool="antismash"
ORIGIN
        1 taccccgctc gtcttcctgg tgggcatcgg ggtctggctg tggacgcagc acctgttgct
       61 ggccggccgc gtcggctggc tgcctctcct gccgggcgcg ctgctgacct cggccgccct
      121 gaccgcgctc agcctgaccg cacggctgta catgccgggg gcgctcaacc ggtccctcgc
      181 ggagtacggc tccctcggcc tggtcctcgt cctgctgtcg tggctgatcg tggtgtccgc
      241 cgcgatcacc ttcgcggtga ccatcggggc ggtgctggcc caggaaccgt cgctgcgccg
      301 gcatccgacg acgagggcga ggccgggggc gaggaagccg tgacgccggg gcgcccggtg
      361 ttttccgggc gccccgtggc cctggaagtc ctccgaggcc ggcgtgcgtg cgccgggcgc
      421 cggcggaggc cggccgcggc agggccggcc gctgcgggac cggccgctgc gggaccggtc
      481 agtccaggcc ggggatcagg gctcggtcgc cctcttccac cgcggccggc gtggcggccg
      541 gggactccgg tcgcgccgcg cgggcgagga gttcggtccg ggtgatgacg tcggtgcggg
      601 tggaggggac ggtgcaggcg tgggctccgg cgatcgctcc gtaccgggcg cagcgccgcg
      661 ggtcctcgcc gttcagccag ccgaacagga agccggaggc gaaggcgtcg cccgcgccgt
      721 tggagtccac caccggggcc gggggctccg cgggcggtac gtggatcagc tcgccgtccg
      781 ccagcagatg ggcgccctgc gcaccggcgg tggccacgac gatccgggcc cggccgcggg
      841 cggcgatgtc gcgcagggtg cgctccgggt cggccagggc ggtggcggac aggaagacga
      901 ggtccgcctc cagggcgaac ggctcgtggt acgggtcggc gccgtcccag tcgtgcaggt
      961 cggtggagag ggtgagaccg gcctcgcgga gcaggggcag cgcctgcgcg cagggagggg
     1021 tgatgacgac gtgggcgtgg cggctcgcgg cggcgagctc gcgcaccgtc gcctcgggca
     1081 gccggtccga cgcggtcgag cgggtgtcgt cgtagaggga cagccgccgc ccgtcggggc
     1141 cgacgaggtt gaccgcgcgc ttggtgcccg cgggctgcgg gatcgcggtg agggggatgc
     1201 cgtggtcgcg gtggagggcg cggaccaggt cgccctcggt gtcgtcaccg atcatgtcga
     1261 ggtggtgggt gcgcaatccc agggcggtga ggccgagggc gacgaagtcg ccgctctgtc
     1321 cggcgcgggc ggtgatgccc ggccggatca tgtagctgtc ggcgaaggcg agcggcagtt
     1381 cggggacgtg gacgacggtg tccacgcccg ccccgcccag gaccaggacg tcggtgtcgg
     1441 aggtcatcgg tttcctctcg ggccgtcgcg atcagccgag tcaatcagca gcctcccgcc
     1501 gcagcaagaa cttgctgaaa actacggcaa gttccacgcg gccggtcgcg acggagaccc
     1561 gggccccgcc gggagcgtcc cggcggggcg gggccggcgc tcggcgtacc gcgtcacacc
     1621 gtgccgacgg cgaggacgtt gccctcgctg atgcaggcgt cggcgtcgtc gagcgggtgg
     1681 cgggggccgg cggggtcggc gaagcgctgc ccctcggcgc tcaggcccag gtcgagggcc
     1741 tgacgggcga gctgcgcgca ggccatcgcg cagaactccc gggcggcgtc cggcaggggc
     1801 gcgtggtgct cgatgaggac ggtccgctgg cgcaccccgg tgagcccggc gctcttcagg
     1861 tggcggtaca gctcccggga gcgcagcagc tgacgggcgt agccgggggt ggcgccggcg
     1921 gtgcggaaga agtcggtgaa cagatcccgg cacgctcgca ccgacgggca cctgacgcca
     1981 ggggctccgg tgcgcatcgc ccctcgatcc gggcgagggc cgcccgccgc cggcgaggcg
     2041 ggcaggccgg agcggacggc gagccggtgc ggaccgcgcg ccccctccgt ccgaacggcc
     2101 cgttcagcgc gtccgttcgg ccaccagcct cggctcctcc tgatcggccc gcatctcggc
     2161 cagcacccgg gtcccgcggt ccgggccgaa ttccagctgg gcgaagatcg cgggcagtgc
     2221 gacgctgggc agcgtgtagg cgaagaggga cgagatgcgc ccctccaggt ccgtccagtc
     2281 ggatgtcacc tccgacacga cctgggcgcc gatccaggag ctgaccagga accggcccag
     2341 gtcgccgggg gccacgtgcg ggtagacctc gccgtgcctc ttggcggcgt ccaccatcga
     2401 ggcgaaccgc tgcgcccacg cctcccacgg accaccgtcc gccagttcct ggagctgtgg
     2461 ctccatggcc agtttggcgc cggcccgcag catgatctcc tggggcaggc gacaggccag
     2521 cgccatcgcc tcgtcgacca gttcctggag cttgtaggtg cgcaccggat agccctgttc
     2581 cgtcacctgc tgggcgaaga tgccctgcac caactgctcc ttggacgcga agtggaagta
     2641 cagggcgccc ctggtgacct gagccttctc gaggatctgc gcgatgctgg caccgtggta
     2701 gccgtgctgc gcgaagacct ccgccgccgc gtgcaggatc gcgccgcggg tccggatcgc
     2761 gcgcaactgc tgtgccatga gttcgtcctc tcgtccgcgc cagggcaccc cccttgctga
     2821 cgcgaatacc cgatccccgc cgcacgagag cacgccgggg aaaagaaacc agatggcagg
     2881 tactttatca atcttgtaag cctggtgacc ccgggtgttc gcacccgaag gtcaccacgc
     2941 tccggcgccc ccgtccacgg ccatggtggc accggtgaca aagctggcct ggtcgctgca
     3001 gagccacacg gcgacctggc cgacctcctc cggatcggcc accctgccct gagggttgcg
     3061 gcggcgcatc cgctcctccg ccgcggggtc ccgggcgaag aggctctcgg acatctccga
     3121 gcgggtcagg ccggtggcga gcgcgttcac ccggacgccg tgctccgcgt actgcgcggc
     3181 ggccgccttg gtcaggccga gcacggcgtg cttggcggcc acgtagggag ccccggccga
     3241 ggtggcacgg accccggcga tactgctgtt gttgacgatc gcgccgcccg taccggccgc
     3301 cagcatggcc ctgatctcgt gtttcataca gagccagaca ccacggaggt tcacatcgag
     3361 caccgtgtcg tagtcggcgt cgtccgtctc gtgcaggagg gccggttcgg tcgtcgtgcc
     3421 ggcgttgttg aacgcggcgt cgagcctgcc gtaccggtcg acggcgagcc gcaccgcccg
     3481 ctccacgtcg tcggagcggg tgacgtcgcc gccggagcag gcgacttcgg cgcccttgtc
     3541 cctcaactcg gcggccagtt cctccagtcg cggggcgcgc cgggccatca gcaccagggc
     3601 ggcaccgtgc cgcgcggcca cccgggccgt cgccgcgccg atgccgctgc tggcacccgt
     3661 gaccagcatg acccggccgg ccagcatccc cgcgccgtag gtcatgccag ggccttcccc
     3721 gccgcccggt cccagagcgt gcccgcctcc gtctctgcgt cgatcgtccg cagcagccgg
     3781 tcgtcgatct cgtcgaggga gccgacgaga tggcggactc cggcctccgt catgagctgt
     3841 cgctggtggc cgtgcgcgaa gtcgctgggg tgtccgacga aggggacgcc cagttccctg
     3901 gccgcctcgg cgacccgggc cacgtcgtcg atgaacagca cctcgtcaca ggcgagtccg
     3961 gcgacgtcga ccgcgatctc gcgcaggccg gggcggatgt cgttggtgca cacgtaccgg
     4021 ggctcgtcga acaggccgtc caggtggccc aggaaccgct ggaagtgcga ggcgtcgagc
     4081 ccgccgtagc agacggtccg cagccccagc gcgcggagcc tgcgcagcag gtccacggcg
     4141 ccgtcgagga tgcgcaccgg gtggtccgcg agatagctct cccgctcccg caggtagagg
     4201 gcgatcgtct ccatcggggt ggtcgacagc ccgcacgtct ccgcgagcac ccggcccgcg
     4261 accacctgcg gctgggagaa gatccggcgc tccagatcgg cggagtacgt gccgccccgg
     4321 ctggtcacga agtggtggat gacggggctg aacgtgtcgt tcagcaggac gccgtcgatg
     4381 ttgagcgcgg ccatgcggat cctgccgagc tgctcggtca tggatgtcct ctccccttcg
     4441 gacggtcgcc gcgcgcgaga cgcggacggc gaccggtaaa cctgatgacc ggtccagatc
     4501 ttcacacgct ccccgccgaa tagtccatgg accatggttc gacgtctcgg tcaccgggac
     4561 gtctcgcccg cgcggagtgt ccgcaagatc acatcgggtg ccctcgcgga atcggccgtc
     4621 ggcctcgcgc cacggcctcg ttccgggcca ccggacgcgg cgaggcggag gaaacggaag
     4681 gccgtgcgga gcttcgtaaa gttgtagcaa ttgccatgcg aacttgcgga gtcggggtgg
     4741 gacggcgcac attcggaggg aaccggccgg gtccgttccg tgcggggcgg cactgccgcc
     4801 cagggcccgt gggggtgtgc gggagggcgt aaggcacgcg tccgccgccg agtcaaggaa
     4861 ggctggaaaa aaaaccggtc agtccgtacg atgctgcccg tcgcgcaccg ctcactcgtt
     4921 cagcgctcca tccgagcccg ctccggctcg gcccgtgttc cggcagctca ccgtcatcaa
     4981 ctgcccaggg ggagaggcac atgactacgt ttgcgcccat cgacagcatg gtcagggact
     5041 tccgggcggc actgcccgct acgacacccg tgggactgac cacattgacg acgaccgttc
     5101 ccaaggagta cgtccaccgc gcggcggtca ccgaggtgtt cctcaccggg tggcggcaga
     5161 ccgacgcgaa cacctgcacc gtgacggccc agtggccgcg ggcccactcg ttctacggcc
     5221 ccgccgcggg cttccacgac ccgttgctgt tcagcgagac gctgcggcag accgtcccgc
     5281 tgctgtccca cgccgtctac ggcgccccca tggaccacaa gcagatatgg cgcgacctgc
     5341 gggtctctct cgaaccgggg gcactgcgcg ccgggaccgt gcccgccgag ctcgaactgc
     5401 gcatccgctg ctcggacatc gagcagcggg gcggcgtgct gcgcgggctg cggatggagg
     5461 tgaccgccac gtgtgacggg ctccccctcg ccaccgcgtc gaccacgttc agttcacaca
     5521 gcggggcgct gtaccggcgg ctgcgcggcg cctacgcgga cgccgggcag gcgatggccg
     5581 acgcggtcga gatgccgccg ccgctgcgtc ccgaactcgt cggccgggac cgcccgcacg
     5641 acgtggtgct ctcgccccgc ggcgacgacg gccgctggca gctgcgggtg cacaccctgc
     5701 atccgatcat cttcgaccac ccgaacgacc acgctcccgg catgctgctc ctggaggcgg
     5761 cccgccaggc ggcccagcac cacctcggcc cggcgccggt cctcgccacg ggcatcgacg
     5821 cggcctttca ccggtacgcg gagctggacg ccccgtcctg ggtcacggcc gagtcgctcg
     5881 gcgacggccg cgtccgcgtg accgtcgaac aggacggcga gctcgccttc gagtgcgcgg
     5941 tgaccacgca cccggccgtg gcctgagccc gcgggcggcc ggccacggct cgcgccggcg
     6001 gtggactccg tcggcccgca ggagccgtcc ggccgccgcc cttcccctcc gcaccgtgaa
     6061 cccgggttcg tggaagcaca gttgccggaa gccgtgccgg gtgagccggc ggcctacagg
     6121 cgcaaggtgt gtatgccgcc gtcgacggag aggaccgtgc cggtggtggc ggaggacgcc
     6181 ggcgtggcca gataggcgat ggcctcgccg acctcctcgg gccgcgccgt acggcccagg
     6241 ggatgacggt cgttcagcgc gtcccgcgcc gcctccgggt cgggcgtccg cgccagcatg
     6301 cgctggatcc agggcgtgtc gacggcaccg ggggccacgg cgttgacccg gatgccctcc
     6361 cggacgtggt cggcggccat cgccagcgtc atggcgtgga cggcaccctt ggacgtcgag
     6421 tagagcaccc gccgcggcac cccggtcagg gcgaagctgg agcaggtgtt gacgatcgcg
     6481 gcggcgggcg acttgcgcag gtggggcagg gccgcacggg ccaggcgcac cataccgatg
     6541 acgttaacgt ccagcacacg ccgccattcg tcgtcgtcgt ttgcgctgac gtcgccctgg
     6601 gcggcgatgc cggcgttgtt gacgacgatg tcgatgcggc cgaagcgcgc gacgacctcg
     6661 tcgacggcgg cgcgcacgga ggcgtcgtcg gagacgtcgc aggcgatacc gacggcgggg
     6721 gcggcgacct gaccggagtc gaggtccagg gcggcgacgc gcacgccccg ggcgatgagc
     6781 gcggcggcgg cggccgcgcc gattccggac gcgccgccgc tcaccacggc cacgagggaa
     6841 tcggacggct gcgttcggct gagggtggcc acggcgtctc cttgcgggtg gggtgcggat
     6901 cgggatggtg cggttcagga agaggggaag gccggtcgcg cgacgaggcg caacgggtgc
     6961 cggcgaggcc tcgccgcggg gcggggctca gcgccccgca ccgcgctcca gccgttccag
     7021 gaggggatgc acctcggcgc cggctgcccc caccgtgcgc ctcgcccacc aggccgaggc
     7081 gagattcgac gtcaggagcg tgctccggcc gaactcccgg tcgagttcgg ccagggcggt
     7141 gagcgtgccc atgccggtgc cggtgaacag cacgacccct tcgtccggca gaccggcctc
     7201 gcgtacctgc gtcaggagcg tcctggtcgt cacgcggtag gggtcgaact cgtgctcctc
     7261 tgccgcccgg cccggcacgg ccggggcgag gacgacggtg tcgaccttga ggccggcctg
     7321 ctcccagaag gagcgggagg tctccgtgag ccacggccag tacggcgaga cgagcgtcag
     7381 gcgggtcgtc ccgaactcct cgcacacggc gaggatcgcc tgcgtggacg actggacggg
     7441 aaagccgaga cgttccgaca gttcggcgac gaaggcgcgg tcgccctgtg gattcagcag
     7501 gtagtgcgag gcgttgcacg ccaccacggc agcgtccaga cgcatacgcc cgaaggcggc
     7561 cagcgtttcc ggcagcacct cgttgtagct ctccatcgtc tccttcactc ccattcccgg
     7621 ggtcagcggg aaacgggagg tgtacacatt catctcggag ccgatcagac ggtggaactc
     7681 cggctcggct atggggtttt cgggaggaac gacaaggccg agacggggca gcgggaaaat
     7741 gtccatggcc gcagattaga gggcgtgggc ggcatcggcg ggcgtattac acgcaccttg
     7801 acgcggcagc acgccattct tgcaactcct ttccgtcttg acattccttg acaatcccct
     7861 acagacattt gacggcacgg cacttactcg ttcccgtatt ccggtggaaa gtaggggacc
     7921 gcatcccgaa ccccagcgaa cggagtcggc ccatgtccag cgccaccctc accggcgcct
     7981 gccccgagtg cgagaccgaa ctgaccgtgc cgccggtcgt ccagggcgag accctgtcct
     8041 gccccgagtg catgctcacc ctccgcgtcg agggcgtcga ggacggcgcg ctgaccctgg
     8101 agatggtcga ggtccagctg cgcgactggg gccagtgaca gccatgaccg gtgccccgcc
     8161 cgttcccatg tcggccaccc tggccgccga cgaggtcctg gcccgcaggc gtcgggccgg
     8221 ggagcaggtc ctgcccatgg ccggcgggga gatcgggctg cccgtgcttc ccgcgctgcg
     8281 ccggcgactc gccgccgcgg cgggcctcaa cgcctacggg cccgtgcccg gaagccacgc
     8341 gctgcgcgcc tcggccgccg ggtactgggg ccggcgcggc ctcgggaccg atccgggact
     8401 cgtcgtcgcc ggaccgggca gcaaacccct gttgttcgcg ctgctgctcg ccatcggcgg
     8461 ggacgtggtc gtacccgtac ccggttgggt cagctacgcc gctcaggccc ggctcgcggg
     8521 cgcgcacccc gtccccgtgg cgaccgctcc gggccagggc ggggtgcccg acccggaacg
     8581 gctgcgcacc gccgtggccg cggcgcgggc cgccggccgg gatccccggt gcgtggtggt
     8641 gacgctcccg gacaacccga cgggcaccgt cgcctcgccc ggcacggtac gccgcctcgc
     8701 ggacgcggca cgggaactcg acctcgtgat cgtctccgac gagatctact gcgacctcgt
     8761 ctgggacacc tcggtgcccg ccgagtcccc ggcccggcac gccccggaac gcaccgtcgt
     8821 caccaccggg ctcaccaaga acctggcggt cggaggctgg cgcaccggag tggccaggct
     8881 gcccgacagc gatacgggac gttctctgca cggccgcctc gtcccggtcg cgagccagat
     8941 ctggtccagc ccgccggcgc ccgtgcaggc cgcggcggcg tacgcgttcg gcgagccacc
     9001 ggagatcgcc gcgcacgtcg cggcctgccg cgcgctgcac gagagggtgg tgcgggccgt
     9061 cgccggccgc ttcaccggcg ccggggcgga cctcgctccg gtgcgcgcca cctgctacct
     9121 ctacccggac ttcgggccgc tgcgggaccg gctggcccac acccacgacg tgcacggcgg
     9181 cgagggactg gtgcggttcc tcggcgagcg gcacggcatc ggggtgctcc cggccggcgc
     9241 cttcggcgag cccggcgacc cgctgcggat ccgggccgcg accagccgcc tgtacggcga
     9301 ggacgacgag cagcgcacca ccgcgctcgc ggcccctgac ccgctcgaac tgccgtggat
     9361 ccgccggaac ctggagcaga tcggcgccgc gctggccgat ctcaccggtt ccccggtcac
     9421 cggctcctga tccgccctcc ccgtccggcc cgaccctcac accgaaggtt cagcatcgtc
     9481 atgacaagcg ccgagccgtc caccggcacc gccgcccctt cgctcccgcc gtccgacgcg
     9541 acgtccgccg cggaccccaa gctgccgctg gcggccctgc tcgcgctggc cgtcgcggtg
     9601 ttcatcacca gcctcaccga gaccctgccc gccggactgc tgcccgacat gagcgccagt
     9661 ctgcacaccg gcgagtcggc caccgggcag acggtgaccg tctacgcgct cgggacggtg
     9721 ctcacggcca tcccgctgtc cgcggccacc gccgggtggg accgcaagcg cctgctgctg
     9781 accaccatgg ccggcttcgc cgtcgccaac accgtcaccg cgctctcggt caactacccg
     9841 ctcaccctgg tcgcccggtt cgtcgcgggc gtcgccgccg ggctggcctg ggccctgctg
     9901 gccggctacg cccgccgtat ggtggcgccc caccaggagg gccgggccat ggccatcgcc
     9961 atggccggca tccccgtcgc cctgtccctg ggtgtcccgg ccggcgcctt tctcggccgg
    10021 gtggtgtcct ggcaggccgc cttcctcgcc atgaccgccc tgaccgtggt gctgctgggg
    10081 tggatcacgg tggtcgcgcc cgaccacccg ggccggcgca ccgcgggcac gatccccgtg
    10141 cgcggcaccc tgcgcgtgcc cggtgtgacg ccggtgctgg tcgtcaccct ggtcttcgtc
    10201 ctggcccaca cgatcctcta cgcctacatc gccgccttcc tcgaccacgc cggcatgggc
    10261 ggccaggtgg acgcggccct gctcgtcttc ggcgtcgcct gcctggtcag catctgggcc
    10321 gtcggcacct gcatccacgc ccacctgcgc accctgaccg tcgccgccac cctgctggtg
    10381 gccgtcgccg tcgccgtcat gggcgtcttc tccggcaccg acgccctggt gtacgtcgcc
    10441 gtcgccctgt gggggctggg ctggggcggg gtgccgaccc tgctgcagac cgccgccggt
    10501 caggccggag gcgagtcggc cgacgccgcc caggccatcc tggtgaccct gtggaacgtc
    10561 gcgatggccg ccggaggcgt cgccggcggc ctcctcctcg acggcgtcgg cgccgacgcc
    10621 ttcccctgga ccgtgctgat cctcctggtc cccgtcctcg ccgtcgtgct cgcggcccgc
    10681 gcgcacggct tccctgcccg gcgtccggcc ggcccgagct gacgggccgc ccggggcgac
    10741 ggacccccgc cgcgcaccca ccgaaacatc cgccgattcc tgaggagacc cctgacagcc
    10801 atgtccatca tcttcgagtg cgagtaccag ggccgccggt acgcgggcca cggcattccg
    10861 gcgaccggca gcaccctcac cctgttcccg gtggccgacg gacagttgcg ggcggccctc
    10921 gtcgccggcc ggggtcccga ggacctgggc gccgccctgc ccggggacgg cgagcgcatc
    10981 gaggtggcgc tcggcgaccc cggcctgagg ttcctccccc cgctgctgcc gaccgcctcc
    11041 aacaactcgc tggtcaacgg cttcatgggg actcatcgat ccaagttcga ccgcgccccg
    11101 gagcccgacg aggagttcac cccgccgaac tactacatca agggcttcgg ttcgtggctg
    11161 cggttgcctg acgagccgct gaccacccag tccgacccgg tctggctgct ggaggagccc
    11221 gaggtcgtgc tggtgtacgc caacgacgag cagggcgtcc cgcactacgc cgggtacacc
    11281 ttcggcaacg acctgaacga catcggcctc cacctgaaga acccgtgggc gtggacgccg
    11341 tacgccaagc tgtgcgagac gtccatcgcg ccctggctgt tcctcggcac cccgccggag
    11401 acggtgacgg gcaccgtcac catcgaacgc gacggcggcc aggcgtggcg gggcgacttc
    11461 tcgtgcggcg ccgactccct gttccaccgg atcccggaca tggccgacta cctgttccgg
    11521 catccgctgc tgcgccggcc gggcctggtc aactacctct tcctgggcgc cgacaaggcc
    11581 acctatcacg acggtttccg gatcgagaac ggcgaccgca tggtcctcga cgtgtccagc
    11641 cacggcgtcg tgctggcgaa cgaggtccgg tacggagccg cggcccccga acagcacggt
    11701 ttcccgcggc cggagtccga accggcgtag cggaccggac ccgtacaaga gcgcggcggc
    11761 accgccccgg ggcggtgccg ccgcgctgtc gtgtgcgcac gtgccggaca ccggcgggcg
    11821 ccgggcgcgt accgagcggc aaggcaccgg gcaccgggca ccggggggga aagcgtccgg
    11881 ccgggcgtca cggcggcggc cggtgacggc ggcgagggtc gcgcgcccgg tggaggaaca
    11941 ccccaggaag gagacccccg gcgggacggg aaggcgaagg gcactcggcc aggcgtcgcc
    12001 ggggtgcggg tacggctgtg cccgccacgg ctcggacggc cgtggcgggc gcatgggcgg
    12061 cgagggggct cagtctccgc cgaggcgtcg gcggagttcg gccttcctga ccttgcccgt
    12121 cagggtcttg ggcagggtgt ccacgaggtc cagccggtcc ggcaggaagc gcgggtcctg
    12181 gccgcgttcc cgcaggtgct cgcggatctc ccggagcgtg ggccgggcgc cgccgcgcgg
    12241 tacgacgacg gccacgaccg ggtcgtcggt ccgtccgtgc gggcccacca gcgtcgcctc
    12301 ggcgatcttc gggtgcgcgg cgaggatcgc ctccagctcc gccatgggga ccacggcccc
    12361 gtcacgcagg atcgcgtcct tggcccggcc cagcacccgg atgccgccgc ggccgtccgc
    12421 acgcgccacg tccccggtgt cgaaccagcc gtcggcggtc agctcggcgt cgaaggcgtc
    12481 ctggttgcgg aagtagccga gggcccggga cgcgccccgt acccgcagcc tgcccacctc
    12541 ggcccgcttg tccgggttgt cgcacaggtc gatgcggatc tgcatcgcgt cgatgggccg
    12601 gccgtggctg tgcgcggacc agtcctggtc gtagtccagc cggctgatgg tgatgggccc
    12661 gaactcggac atgccccaca ccgagtaggt ggtggtgtcg aacgtgtcgc gcagctcgtc
    12721 caccagctcc tggaggaccg gcgccgcccc ggtgacggtg tggcgcaggc tgggcacctc
    12781 gtgccggtcg gcgcgctggg ccgcggccac cccgaagagc gtcgccggcg gcccgtacag
    12841 cagcgtggcc ccgtaccgct cggccaggtc gagcaggctg gtgtggttgc gcccgtcctg
    12901 gaaggcgacg gttccgccga gcatcacccc cgcgaggatg ccctggccga accccgagta
    12961 gtgcaccagc ggcgtggtga cgaccgccac caggtcgtcg cggagcagga aggtgtcgac
    13021 gtagccccgc acgcccgagt ggacggtgtt ctggctgtgc acgacgccct tggagaagcc
    13081 ggtcgtaccg gaggtgaaga ggatcacgaa cggttcgtcg ggaccgagtt cgcggccctc
    13141 caggtcgtcg aggtgctcct cctcccaggg caccgcgacg aagtggtcgt ggaagtcgac
    13201 ggtgccctcg gggccccggc cgccgaccac gaccacgtgt tccactgcca gttggggccg
    13261 cagcgcggtg atgctcgcgg cgagcgggtg gtcctgccac tcggcgaggg tgacgcacac
    13321 ccgggcgccg gtgagctgga ggcggtggct cagttcggcc tcctggcact ccggcgcgat
    13381 ggggcagatg acggcgccga cggccataca ggcgtacatc agcggcacca tctcccaccg
    13441 gttgggcagc tggaccgcga cgacgtcccc gcgccgcacg cccagttcca gcagggcgcc
    13501 ggcgaaccgg tccgtcagca gggagagttc ggcgtagtcg agggtgtcgg tgcgggcctc
    13561 gtcgaggcgg cggccggcga cggccagctt gcgcgggcgt atccgggcct gccggcgcag
    13621 gtcgtcgagg aaggtctcgt cccgccacca gccgcacgac cggtactcgg ccgcgcggtc
    13681 gggggcgggc accgcggccg gggccgcggc cggggcgtag ccggtcgtca tcggagttct
    13741 ccacgtcgga catcgagcag ttcgggcagc gggtcgccgg cgcgcgcggc ggcgatctcc
    13801 agcagggccc gggtgttctc ccgtacccgg tcgccgatcc agtcgaagac ccacgccttg
    13861 cgggcgtcgg cggccagttc gaaggggacg acccgggtga cggcgagggc ggcggcgccg
    13921 gccccgccga tgttggcgat gacacccggt accagcgtgg cgccggccgc ccgcgccttc
    13981 tcccgcgcct cggcgtcgga ggcgaggttg gcgccctcga cgaccaggcc ggcgcgcagc
    14041 cggtgggcgt tctcggcgtt cagcgcgtgc ttctgggcgg cgaggaccag cacgtcggcg
    14101 tcgatgtcga gccaggcgtc cggcgtgctg gtggtggtga cgtgctgcgg cagccgggag
    14161 cggtcgatgc ggccgaactc gtccgtgacg gcgatgagtt cggcgaccgg cagccggtcg
    14221 gcgctgatgg tgccctgcac gtcggcgacg cccacgacga catggccgcg gtcctccagg
    14281 aaccgcgcga cggcgcggcc cacggcgccg aagccctgca ccacgacccg ggcggcctcg
    14341 ccgcggccgc tcgcctccag cgcggtgacc gcggcgacgc cgacgccgtg cccggtgacg
    14401 tcgatgagcg gctcgtagta ggtgcgccag tcgacgggca tgtccggggc ccccgggcgg
    14461 taccgcgggt cgtagccggc ctcgtcgaag aacacggccc ggtcggcggg ggtgacgccc
    14521 atgtcgatgc cgaggtggat gccgccatgc agcagcggct tgacggtgcg tccgaaggtg
    14581 cggaaggtct gctcgcggtc gccaccgtcg gagacgatgc cgcccttggc gccgccgatg
    14641 cgcaggcccg ccagggtgaa cttctgggtc atgtcgcggg ccaggcccgc gacttcctcc
    14701 acggtgacgc cgggggtcat ccggacgccg cccatcgcca ggccgtcgac cagcgtgtcg
    14761 atgaccaccc agctcctgat ggtgccgccg ctgccgttca ggtggacgac gagcgcggga
    14821 tcctgtgtgt tctctgcatc actcattgcc aagtactcca gtcgtcgaag tgggtgacgg
    14881 tccgcgagag tccgctcact ggtagagctg ggcgaagccg cggaggatct ccaggccgtc
    14941 gccgcggaac tccaggtggg cctgcgagcc gtggatgcgg ccgtcgtcgg agcgcaggaa
    15001 ctccacgggg gcgtgttcgg agcggccgat ggagcggaag ccctccggcg cctcgcggag
    15061 gtagagggtg tgccggtgga acaccgtcac cgtcggcttc acatgggtga agagcggctc
    15121 gtccttgtcg acctggacct cgtagccgcc gacccgctgg gggccctccg ccagccggcc
    15181 cccggcggcg acggcgagga tctgcatgcc gccgcagatc ccgaagaccg ggacgtcgga
    15241 ggtcatgacg aggtcgacga gcggcttgta gtagtcctgg tcgtaggcgc gcaccttggt
    15301 gccgctgagg acgatcgcct ggtagcggcc gtcgagccgg gacggtacgg aggccgcgtc
    15361 gacggtgtcg gtgtccgagc ccagcgtctc gaaacggccc cggagctgag gcagcgacag
    15421 tgtcttgttg ttgacgacca gcacacgagt tttcgccacg gttgtgctcc tcaggttcgg
    15481 gtgatgacgg tgccggtgcg ggcggcgagc aggtccgaga cgggtgcgct gccgatgacg
    15541 acccgctcca cgccccggtc cagggcctcg ccggcggcgc gcagcttctt gcgcatgcct
    15601 ccggtggcgc ccttgtcgcg gaactcggcc gccgcctccg cggtgatctc gcgcaccggt
    15661 tggccgtcga tcagcaggtg cgcgacgtcg gtgacgagga tcaggtcggt ggcgccggtg
    15721 gccccggcga tggcggcggc ggcccggtcg gcgtcggtgt tgacctcccg gcccgcgctg
    15781 tcgcgggcca ggggcgtgac caggtgggcg tggccgggcc tgagcttcgc cagcggcgcc
    15841 gggtccaccc cggtgatggg gccgacgagg ttctccagtt cgaccagtcg cttgtccttc
    15901 caccaccagc gctcgccctc gccggcggcg accaggccgt cgctgccgag cagccgctcc
    15961 gcggtgatgt cacgccgctc cagccggcgc aggacctccg cgcccaggtc ggcgctgacg
    16021 gtcttgatgt cggcgatgac ctcgggtgtg gtccagcggc tctggttgcc gtagcggtcg
    16081 cgcaggatcg ccgacggctc gctgtagcgg gggctgagcg ccttcagcgg cttggaccag
    16141 ccgtgcacga ggaccagcgg gcgttcccgg ccgtgccggg cgaggtcgtc ccaccaggaa
    16201 ccgtcgaggt cggccaggca gctcccgccg agcttgacca cggtcggggc gtgctggatg
    16261 ccggtcatgc gggcatcacc ggctgcatgg tcaggcccgt ctcctcgggc agccggaacc
    16321 gcttgttgac ggcctgcacg gcctgcccgg cggcgccctt gaccaggttg tccagggcgg
    16381 cgaggacgac gatgcggccc ccgtccgggt cgtgcatggc ggtcacgtcg cagtagttgg
    16441 agccgagcac ggcctgcgga tcgggcaccg ggatcagcgt ctcgtcgtgc cggcgcaccc
    16501 ggacgaaggg gtgctccttg tagaaccgga agtacgcgcg ctggagcgtc cgctggtcga
    16561 ccgggtcgtc ggtgtacacg taggagctgg cgagcagtcc gcgcacgtgc gacaccccgt
    16621 acgccgacat ggccagggaa ccgacgctgc ccggcttgct gcgccggagg aagtcgccga
    16681 cctcggcggc gtgccggtgc ccggtggggg cgtagggcgc gatggcgccg ttgcgcagcg
    16741 ggtgcaggtc cggcacgcgc agttgcaggc cgccgccgct ggagccgctc ttgccgtcca
    16801 ccacgaccgt gcgcagatgc aggccgagac cgagggtcag cggggcgagg ccgagggtga
    16861 tggcggtggc gtagcagccg ggcaccgaga tcagcgcggc gtccaccagc tggtcgccga
    16921 cgagttcggg tacgccgtag acgaaccggt ccgccagttc ggtggcgcgc tcggccttgg
    16981 cgtaccagcg ccggtggagc tcgggggtgc ggatgcggaa ggcgccgctg aggtcggtca
    17041 cgcacggcac gcggtcggcc agctcggcgg cgagccgcgc ggacaccggg gcgggcgtgg
    17101 ccaggaacac cacgtcgcac ttctcggcca cccggtcggc cgtgacgggc tcgacggtca
    17161 ggcccaggtc gaggcggagg cccgggtgca gttcggcggg ccggcggccg gcgctggagt
    17221 cgccgcccag gaaagtgagt tccagctccg ggtgctggct gaccagtcgg atgagttcgc
    17281 cgccggcgag tccggacgcg ccgacgattc ccacacggat cattcgagag tctcctggac
    17341 gtaacggacg acgaccgacg cgatgtcggt cccggtcgtc gatgccactc cgcgccaggc
    17401 gggggcgtgg ttgacctcgt tgacgaggta gccggatccg gtcttgaaca ggtcgacgcc
    17461 gtagatgccg ctgccgaggc ggtcgacgac accgtccacg atcttctgca cctcggggtc
    17521 gtgcgccagc gcccggctct ggctgcccag ggccgcgttg ctgcgccagt cggtgcccgc
    17581 gctctcgaac tcggcggcgg cgacgatgtc ccggccgacg accaggcagc ggatcgagcc
    17641 gccgccgagg tagggctcca ccaggcaggc ctgctcgaag gcgtgtccga ggtcctcgac
    17701 gtagtcgtac acggactgcg ccaggtcgga gtcgcggacc agggtgacgc gcttgcccat
    17761 gccgccgtag accggcttga gcacgacggg gacgcccagt tcgccgagcg cgcgctcgaa
    17821 gtccttgcgg gacagggcga gccggaagtc cgggacggga accccggcct cgcgcagcac
    17881 ggcgcgcagg acgagcttgt tctcgcagga gtggatcgcc tgggcggagt tgaggacccg
    17941 gaagccgtcg gcctcggcga gggtggcgat caggccgccc cgggtgtagc tgcggctgcg
    18001 caccatgacg gcgtcgtagc ccttgagcga ctcggcgtcc cggtgaccgg cgcacaggga
    18061 ctcgtcgttg acccagtcga aacgcacgcc gaggtccggg ccggtctcga tcagccggcg
    18121 ttcctcccag ccgacgcggt cggcgacgac tgctacgcgg ccggccatgt cactggcccc
    18181 agtcgcgcag ctggacctcg accatctgca ggcccagccg gccgttctcg atgccctcga
    18241 tccgcagcgt gagcatgcac tcggggcagg acagggtctc gcccacgacc atctcgggca
    18301 cggtcaggtc ggtctcgcac tcggggcacg agccggtgag gacagcggtg ctcatggaac
    18361 gactccgatc aggtgatgaa tacggcgggt gcggaatgaa gaaggaggtg cggggacggt
    18421 cccggtgcgg taaggacgag gtgcggggac ggtcccggtg cgggatcgtg ctcaggcggc
    18481 ctggaagtcg atggcggcct tgcggaccgc ctcctggtcc agcaccgggc gtccggcgag
    18541 ctcctggcgt tcgatcagcc aggcggtgaa cgcctcgacg tccacggcga tgtccgagcc
    18601 ggcgagcgcc cacttgacga gcgccggggt gagccgggta cggacgcgca gctcacggct
    18661 gttgccgacc agctcggccg gcagcgtctc gtacgcctcc gggttgctga gctggcccgg
    18721 cagctcgtag gcgaaggcgt gcggggtcgt cgggccggac tggaaggcgt cgccgaggcc
    18781 ggcgccccgg agggcggccc gggacagctc cgtgaggtgg gtcaggtcga accgggtgtc
    18841 gccgtggatg acgcgcagcg aggtgagcag ctcggccagg ggcgcgttgc cgccccgctc
    18901 gccgatgccg ccgacggtcg ccgagatcca gcgcgctccc gcgcggacgg cggccaggga
    18961 gttggcgacg gccatgccga gcatgttgtg cgagtggatc tcgatctcgg aaccgtcgat
    19021 cgcggtgagc ccggagatca cctcctccat ctgccagggc gacaggtagg cgacggtctc
    19081 cgcgagccgg aaccggtcgg ccccggcctc gaagccggcg gcgacgtagg gaatcagccg
    19141 ctccttgggg gtgcgggcgc cgtcctcgcc gctgaaggtg acgtggaagc cgcggtcctt
    19201 cgcctgcgag atggccgaac gcgccagcac ctggaggaac ttcgcgctcg gcgagcccag
    19261 cttcagcccg gcgtgctgct cggaggtcgg gatggagtac atgatgtgcc gcacgcccag
    19321 ccgctcggcc tcgtcgaggg ccttcgcgac ctgctcgcgg tcgcgcacca ccaggagcgt
    19381 catgctgcgc tcggggccga tcgcctcgtg cgtggcgagg accaggtcgg cgtccttgga
    19441 gtccgggccg gacaccatgc ccacctcgac caggtcgatc ccggtgcgca ccagcaggtc
    19501 cgcgatgacc gcggcgtcct tggggccgaa ttcgacgcct cccatgtggg cggagtcgcg
    19561 cagggtcgcg tcggacagct ggggaagccc cggaaggctc ccgtcgttct ccggatcagc
    19621 cattgcgttc cctccttgcc gggagcctgc ttttcgcggg ctccgcgctg gatttacgct
    19681 gcctcgaaca tgctgcgcga cgctctgcaa agaagccctg cgccctctgt cagagctgtg
    19741 tcaagggctg tcagggaatg tcacgccggg caagccgtgc gaataattca ggctcggaat
    19801 gaattccgga aacggcttcg tcccccgtcc ggcaagccga aacggcccgc cgcggaatgc
    19861 ggcgggccgt ttcacccggt cgacggggcg acttcggggg gtgaggtcag gcggtgtacc
    19921 caccgtcgac ggcgagggcg gtgccggtga tgtaacggcc gcccggaccc gccagatagg
    19981 ccaccgcggc ggcgatgtcc tcggcctctc cgtagcgtcc gagggcggtg agggagcgct
    20041 gccagtcggc ggagtcgccg tcggccgggt tcatgtcggt gtcgatcggc ccggggtcca
    20101 cgacggtggc ggtgatcccg cgcggtccca gctcccgggc gaggcccttg gtcagcccga
    20161 tgagcgcggt cttggccgtc gcctggagga cgaagttccc ggcggggaca cgcccgttga
    20221 agcatgagcc gacgctgatg atccggccgc cgtcccccat gtggcgggcg gcggcctggg
    20281 cggccaggaa caccgagcgg acgtccacgg cgagcacctg gtccaggtgc tcgacggtca
    20341 cctcgtccag cggaccgtag gagaggaagc cggcgttgtt caccaggatg tcgatgccgc
    20401 ccagctcccg caccgtctgc tccacggcct ccgccgcgtc gtcgggacgg gtcaggtcgg
    20461 cccggacgac cgcggccctg ccgccgtccg cctcgatccg cttggcgacc tcgcgcgcct
    20521 ggtcctcggc ctggacgtag gtcagcgcga ccgctgcgcc cgcgtcggcc agccgcttcg
    20581 cgatcgccgc cccgataccg cggctgccgc cggtcaccag cgccaccttg ccggtcaggt
    20641 cactcatcgc tgcttcctcc gtaaacgact cgatgttcct cgaccgctac gctagaagtt
    20701 gacaccggcg tcagattcaa gtcctcgcgt ggaggggtcg ggtgggagat gcggatcggt
    20761 gaactggccc ggcgcagcgg ggtgagcgag cggtcgctgc gctactacga ggcgcagggt
    20821 ctgctcagcg ccgagcgcac cccgggtggc caccgcgact acggcgagtg ggccgtcgac
    20881 cgggtcatcc gcatccaggc cctgtacgcc gcgggcctga acagcaagaa gatcgcgcag
    20941 ctgctcccct gcatgcggga cggtgacggc tcaccgagtg acagcgcgac cccccggctg
    21001 gtcgacgagc tcaccgccga acgtgaacgt ctcgaccggt tgatcgccga cctggtccgc
    21061 tcgcgtgacg tcctggacga catcatcgac accgcgtcga cgggcctgga ggccgccccg
    21121 ctcaccggca gcggcggccg cccgccgggt cactgagccg tcgccgtcgc cgcggaccgg
    21181 gtcacgccgc ctcgtccacc agggcggcca gcgcggcgcg cgcgtgccgc tccgcttcgt
    21241 cggggctcag ccgcgcgcca cgctcgaacg actcctcgaa ggcccgcacg cccagcaccg
    21301 cccgtgccgc cgcggtgacg cggtcgacgt cgccgcgctc ggcgggcggc aggggcgcgc
    21361 ccacgctgcg gcgggcggcg tgggcggcgc cgagcagcag ggccgcgcag acggcaccgg
    21421 accggtgtcc gcacagggtg gccgtaccgg cgagcccttc cagggagagg gcgagggcgc
    21481 gcggctcgcc gagggagcgg gcgatccgca ggccgcgcag ctggtgggcg gcggactcgg
    21541 cggcatcgcc gcggagttcg gcgatgaagc cgagttcggc gtggagcagg tggtcgccgg
    21601 ccgcggagga gacgtcggcg tggtcggcgc ggatgcgcag caggtgcgcc tcggccgcgt
    21661 cgatgtcacc ggagcgccgg gcgccgaggg cgaggcccat gtcggcgtgg atctcgccgt
    21721 acttgtagcc ctgttcgacg gccaggcggc gggcctgttc gtgcaggtcg cgggcgcggt
    21781 cgaagtcacg ggcgagcagc gcgaggcggc ccagcccgga cagccgggcc gagacctcgg
    21841 cccgcaggca cagttcccgg gccatctgca gcccttcgtg ctggcggtgc gccgcctgcg
    21901 cgtactcccc cttgatctcg gcgagcgcgg cgagcggtga gacggtctgc agttcgcccc
    21961 agcggtcgcc cagttcacgg aagagggccc ggctgcgccg tccgtcgcgg gccagtccgt
    22021 ccaggtcgcc gcggaccagg gcgagcgccg cccgtacccc gagcgcggcg gcgatgcccc
    22081 accggtcgtc cgcggcctcg aaatgggcga gggcacgggt gttccaggcg cgggcgccgt
    22141 ccaggtcgcc gacgccgaac atcccgtggg cgttcagcca cagtgcccgg gcgcggcgca
    22201 ccggatcggg tacggcgtcg gcaccggcgg gcaccgtgcg ctcgccggtg agcagcacga
    22261 acgccccgtg cagcaaggtg agttcggggt cggggtcggg tgcggtggcc gcgaggacgg
    22321 cggccagggc gcggcggccc tcggtgaggc ggccgcgcag cagccaccac caggacaggg
    22381 cggtggcgag ccgtacggcc tcctcgccgc gtccggcggc ggcccgtcgt accgcctcgt
    22441 cgagggcggc gcgcaggttg ccggcctcgg tgtccaggcg ggtgagccag tcccgttgga
    22501 gggggccgcg cagccgccgc tcggcgcgtt cggcgagcgt gaggtggtgg cgcaggtggc
    22561 gctcccgggc cgcgggttcg ccggccgtct cgcgcagccg ttcgacggcg tacgcggcga
    22621 ccgactccag gaggcggtag cgggggcccg tggggccgtc cgtgacgacg accagggact
    22681 tgtcgacgag ccgggtgacg aggtcgagga ccgcgccggc cggcacgccg tcgcccgcgc
    22741 acaccgcctc cgccgcgtcg aggccgcagc cgtcactgtg cacggcgagg cggccgagca
    22801 cggcgcgttc gggcgcgtcc agcagctccc agctccagtc gatcacggcg cgcagggtct
    22861 gctggcgggc gggcgcgccg cgctgtccgg aggtcagcac ccggaaccgg tcaccgaggc
    22921 gtgcggccag ctcccgtacg cccagggcgc gcacccggga ggccgccagc tccagggcga
    22981 gcgggatgcc gtccaggcgg cggcagatct cggccacggc ggcccggtcg gatcccgggt
    23041 ccgcagcggc gccgtcgggg tcgtcggagc cgagccggaa gccgggcgcg caggcggcgg
    23101 cccgttcggt gaacaggcgg acggcgtcgg gggtgtggag cggttcgacc aggaagacgc
    23161 tctcgccggc cagggcgagc ggttcctggc tggtggtcag gacgcgcagc cggggcgcgc
    23221 cgcgcaggag ccggccgacc agttcggcgg cggcctcgac gacgtgttcg cagttgtcca
    23281 gtacgagcag ggtgtcgcgg tcgcgcaggg cggcggtcag ccggtgcacg ggagaggtgg
    23341 ccacggggga cacggcgggc ggggcggagg gagcgtcgtc ccgcaggccg agcgtcgcgg
    23401 cgacgatccc ggcgagggcg tcggcggtgg cggtggcggt gcggaccccc gcgaactcga
    23461 cgaaccaggc cccgtcggca agtccggccg cgccgccgga ggcgacgtcc cgcgcggcgg
    23521 ccacggccag gcgggtcttc ccgacgccgc cgggaccggt gagcgtgacc agccgctcgc
    23581 ggccgaggag ccgggagagc cggccgaggg cctgatcgcg gccgatgaga gcggtcaggg
    23641 gcacggggag tccggcgggc gcagagggcg ccgggggcgc agagagcgac gcagagggcg
    23701 tcgggggcgc gggggatgtc gggggcgggg aggccgtcga gggcgtgggg gatgccagag
    23761 gcgcagaggc tgtcggaggc gcagaggatg ccggaggcgc gggggatgcc ggaggcgccg
    23821 gggcggtcat ggggtgcggc gagggtgccg ggtgcggcgg taccccgtcg gacgacgcgg
    23881 ccgggggctg ggtgtcggcg tccagcgccg ggtcctgacg gagcatcgcc cggtggagcg
    23941 cgctcagtgc gggtccgggg ccgaccccca gctcccgggc gagccgggtg cgcagatcgt
    24001 cgtacgacgc gagcgcctca ccctggtgac ccgcccggta cagcgcccgc atctgcacgg
    24061 cgcgcagccg ctcccgcagg ggatgcccgg acacgagcgc ggccagctcg ccggcgagca
    24121 gccggtgctc ccccgccgcc agccgcgcct cggcgcgttc ctccagcgcg gccagccgct
    24181 cctccgccag gcactccccg gccgcccgta cgaactcctc gtcggcgaag tccgcgtacg
    24241 ccggcccccg ccacagcttg agggcctcgg tgagcagcgc cgcccgcgcc cgcgggtccg
    24301 cggtggagcg cgcctcggcg aggaggccgc cgaaccgcgc ggcgtcgacc tcgtcggcgg
    24361 agccgagccg cagccggtaa ccgggcggct gccgcagcag ccgctcgcgg ccgacgaccc
    24421 ggcgcagctg ggagaccttg gcctgcagag cacccgccgg attgccgggg aggctgtcgc
    24481 cccagaggtc gtggatgagc cggtccgcgg agacagggcc gccgtcctgc gcgaggagat
    24541 ccgcgagcag cgcccgcacc ttggtctcgg ggacccgcac cggctcccct tcgtcgtccc
    24601 acaccgcgag tggtccgagc accccaaacc gcatgcgctc aacctacccc tccggcaagg
    24661 cgcccacctg ttcggtcatc ggctccgaag cgttccccaa ggattcccga agcattcccg
    24721 aagcggccgc gcgcacagtg aggtcgccgg acggccccgc ctcccagggc gtgcccggca
    24781 gcgcacttca ggagatacgg agaacacccc catgagcctc tcacccgaca cggctgccgc
    24841 ctccgacacg gccgccgccc ccggcacgga gcccggcacc gcgccgcccc cgcggcagga
    24901 cagcggggag cggcggcggg gactgccgct ggcggcgctg ctcgccctcg ccaccgcggt
    24961 gttcgtcacc agcctcaccg agacgctccc cgcgggcctg ctgcccggga tgagccacga
    25021 cctccgggtg agcgagtccg cgaccgggca gacggtcacc gtctacgcga tcggcaccgc
    25081 gctcaccgcg atcccgctga cggcggccac cgccggctgg cggcgcaagc ggctgctgct
    25141 caccgccgtg gcgggattcg ccgcggccaa cacggtgacg gccctgtcgt ccgtctacgg
    25201 actgacgatg gcggcccgtt tcgtcgccgg tgtcgccgcc ggagtggcgt gggcgctgct
    25261 cgccggctac gcgcggcgga tgacgccggt tcccctgcag ggccgggcca tcgcgatcgc
    25321 catggcgggc attccggtgg cgctctcgct cggcgtgccc gccgggacct tcctcggcca
    25381 ggccctcggc tggcgggtgg cgttcctggc gatgacggcg ctcacggtgg tgctgctggg
    25441 gtggatcgtc gccgcggtgc ccgaccaccc gggccggccg agcggtgaac gtccgctcat
    25501 gctgcgagcg ctgggggtgc cgggcgtgcg cccggtgctc ttcgtcacgc tcctgttcgt
    25561 gctggcccac acggtgctgt acgcctacat cgccacgttc ctggacgacc tggggatggg
    25621 cgaccgcacc gatctggtcc tgctcgtctt cggtgtcacc tcgctcgccg gcatctgggt
    25681 cgtgggggcc cgcatccacc gccggctgcg cgcgctgacc gtcgccgcca ccctgctggt
    25741 ggcggccgcc gccaccctgc tcgcggtgac cggcgacggc ggcgcgccgg tgtacgtcgc
    25801 cgccgccctg tgggggctgg gctggggcgg gctgcccacg ctgctgcaga ccgccgtcgg
    25861 cgacgcggga ggcgaccacg ccgacgccgc ccaggcgatg ctcgtcacgc tgtggaacgt
    25921 ggcgatggcc ggcggcggcg tgctgggcgg tgtgctgctg gaggtgaccg gcagcggttc
    25981 cttcccctgg acggtgctgc tgctcctgct gccggtgctc gccgtcgtgc tcgccgcccg
    26041 gcgtcacggc ttcccgtccc ggcgccccgg cgcgtaggtc cgccaccgcc ggcggcacgg
    26101 tcccgcggta cgcggctcgc cccgtgctcc ccggcacgca acgtgatgtt cacagtcccc
    26161 cggctccccg ggggctctct tccggacggc cctcgccggc cgtcgccgtc agcggccgcg
    26221 gatcccggtg gggtcgtgtg accagcggaa agggttcttc tcacggcggt ccccggtccg
    26281 ggaaaaggct ttccacggcg ggggatccgc tgccggccgg agatctctcc cgagcgcgaa
    26341 tccgctggtc agcgggcgaa atgtcaaagt gaccgggcgc accgtgaaat cggcggacaa
    26401 gccggtagct ttgtccctcg tacgactgtc cgcacgtcga cacgacgagg cgacacgact
    26461 gcgagggggc gtagttaaac atgtcgtcat gggaggtgcg cgtcgcggct ggggagcgcg
    26521 agcgcttaca catgttcgtc gagaaagtat tcaattcact gcaccgcgcg gaacaacgcc
    26581 gttgggcgcg ggaatatctg tggggactcc tccacacacc cggcaagaag acaccgcggc
    26641 gcatggccga ggccggattg ctgccggccg gagcggcgca cggactgcac cagttcatca
    26701 acggcagtcc ctggaactgg cagccggtgc gctgcgcact cgccgggacg gtcgcggcgg
    26761 gcggaccggc gtacgcctgg acgtgcgccg atctcctcat cccgaaacag ggcgagcact
    26821 cggtgggggt gcaccgtcgt ctcgaccagg cgaccggacg caccatcaac tgccagcgcg
    26881 ctctgggact gttcctgtcg acgggcaccc ggtgcttccc ggtcgactgg agcctcgtgc
    26941 tcgacggcga gtgggactgg gacgacctgc gcaggcgccg tgcgcgcata ccggaggagg
    27001 agaccgggcg tcccgtgggt gcgtacgtca tcggcttcgc cgccggggtc gccgcgcaca
    27061 cccggttgcc cgacgcgccc tgggtcctca acctcacccg gcggtgcgac gacgcgagcg
    27121 gtgtcatggc cggactcgcc cgccggggac tggacttcgt gtgcgaggtg gagtcgagac
    27181 agatcgtcct catcggccgc cccgcaccgc gggtgatcac cgtgggggaa ctgatggagg
    27241 agccgcatgc ccggcagccg cacgtcctga tgcgccagac ggagcacggc ggttcgaggg
    27301 cggtccgggt caatgtgtac ggcggaccgg tacgcctgtc gcagcgcggg gccggcaagg
    27361 acggcgtctc gcgtacctac caggtcctgg aactgccttc cgccgacggc gcgcagcccc
    27421 ccaggtactg gatcaccagt ctgatgagcc gcggcgtgga ggaggtcctg accctggccc
    27481 ggagccagtc caccgccctc gcgacggtcg ccacggtgcg ggagggattc ggcgtgctcg
    27541 acttcgaggg ccgctccttc cccggctggc accaccatat gaccatggtc tcggccgcgt
    27601 acgcctacca gcgcctgtac ggcactcccg gcgcgggctc cgcgccggcc gtaccgctgc
    27661 ccgtggcgca cgccgggacc acggcccact acgcggacgc cggagcgaaa ggcctggggg
    27721 cgtgaagaga gtgctggtcg tggagccgga cgccggcgcg gccgagagta cggcgggcga
    27781 gctgcgccgg caggggtacg ccgcccacac cgtcgacaga ggagcgcgga tgctgcgcac
    27841 gtaccacgac gccgatctgg tgctgctctc cctggacctg ccggacatcg acggactgga
    27901 ggtgtgccgc acgctgcgcg ccgagagcga cattccggtg atcgcctgca cgcaccggga
    27961 caacgaactg gagcgggtcc tcgcgctcaa ggcgggggcg gacgactgtg tgctgaggac
    28021 gtggagcccg cgggagatag gggcacggat cgaggcggta ctgcggcgca cccggccgca
    28081 ggccgcaggc gcggacagca tctcgctccg gccgctgcac atcgatccgc ggacccggga
    28141 ggtgcgcctg cgcgaccggc tcgtcgacgt cacggccacg gagttcgaac tgctctacac
    28201 ccttgccgcc cggcccgatt ccgtcgtctc ccgcaaggag ctgatggcca gggtctgggg
    28261 cagcaactgg gtgcggacca gccgcaccat cgacacgcac gtgagcagcc tgcgggcgaa
    28321 actcggctcc agccggtgga tcatcacggt gcgcggggtc ggctaccgca tggggcacgt
    28381 ggggcagatg cccgaggcgt ccgccggctg agacgtcccg tgcccggagt ccctgatccc
    28441 cggcacggcc gattccccgc gtcgccgatt cccgacatcg gtgattccga tgtcgccgtt
    28501 cccctacgac ctcgattccc ggcgccgatt cccggcgtcc tgaatctccg gatccccgat
    28561 tgcccgattg ccgacgtcct cgtctcccgg cgtccgcatc tcctgtacgt cgtttcccga
    28621 cgccctgttt ccgacgcttc cgagggagcc ccgccttggt gagacatgcc cttatcgagt
    28681 tcgccacccg aggagtgagc ggcacatgac gaaacagatc cacctcgccg cgcagctgcc
    28741 gggcatccac aacgtcaccg tctggccgga cccgcgctcg gggagccaga tcgccgtcga
    28801 ctccttcgtg cacctcgcgc ggacggcgga gcgcggcagg ttcgacttct tcttcctcgc
    28861 cgaggggctg cggctgcgcg agcacaaggg ccgcctctac gaactggacg tggcgggccg
    28921 cccggacaac ctgacgatgc tcagcacggt ggccgccgtc accacgcatc tcggggtcgc
    28981 cgccaccgtc aacgccacct tcaacgagcc gtacgaggtg gcgcgccggc tcgcgaccct
    29041 ggaccacctc agcggcgggc gtgccgcctg gaacgtggtg accagcttcg actccttcac
    29101 cggtgagaac ttccgccgtg gcggcttcct cgccgaggcc gaccgctaca cccgcgccgc
    29161 cgagttcctg gccacgacgc gtgagctgtg ggacagctgg gccgggccgg acctgcgcgc
    29221 cgaccccgtg tccgggcagt tcgtccgtcc gggcgccggt gagttcgccc accgcgggac
    29281 ccacttcgac atctcgggac gcttcacgac cccgcccggc ccgcagggtc acccggtgat
    29341 catccagtcc ggggagtccg acgcgggacg cgagttcgcg gcgtcggacg ccgaggtcgt
    29401 cttcagcaag tacaaccgcc tcgacgaggc ccgcgccttc taccgggacg tcaagggccg
    29461 gctcgcccgg tacggccgct cccctgccga cctgcggatc atgcccacgg ccaccgtggt
    29521 cgtcgccgac accgacgagg aggccgtggc ctacgccgac gagatcaccc gggcccaggt
    29581 gagcccgcag accgcgatcg cccacctgga ggccgtctgg ggc
//
